{ "uniprot_canonical_ac": "A0A0R4ISF7-1", "uniprot_ac": "A0A0R4ISF7", "uniprot_id": "A0A0R4ISF7_DANRE", "mass": { "chemical_mass": 146575.0, "monoisotopic_mass": 146575.0 }, "refseq": { "ac": "XP_700384", "name": "A disintegrin and metalloproteinase with thrombospondin motifs 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_700384" }, "gene_names": [ { "name": "adamts2a", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ISF7", "id": "A0A0R4ISF7" }, { "name": "adamts2a", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_700384", "id": "XP_700384" } ], "protein_names": [ { "name": "A disintegrin and metalloproteinase with thrombospondin motifs 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_700384", "id": "XP_700384" }, { "name": "A disintegrin and metalloproteinase with thrombospondin motifs 2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ISF7/entry#names_and_taxonomy", "id": "A0A0R4ISF7" }, { "name": "ADAM metallopeptidase with thrombospondin type 1 motif, 2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ISF7/entry#names_and_taxonomy", "id": "A0A0R4ISF7" } ], "function": [ { "annotation": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133196) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 12, 2025 this sequence version replaced XP_700384.3. COMPLETENESS: full length.", "evidence": [ { "database": "RefSeq", "id": "XP_700384", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_700384" } ] } ], "disease": [ { "disease_id": "DOID:0080733", "recommended_name": { "id": "DOID:0080733", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080733", "name": "Ehlers-Danlos syndrome dermatosparaxis type", "description": "An Ehlers-Danlos syndrome that is characterized by severe skin fragility, sagging, redundant skin and that has_material_basis_in mutation in the gene encoding the procollagen protease ADAMTS2 on chromosome 5q35." }, "synonyms": [ { "id": "MONDO:0009161", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009161", "name": "Ehlers-Danlos syndrome, dermatosparaxis type", "description": "A form of Ehlers-Danlos syndrome (EDS) characterized by extreme skin fragility and laxity, a prominent facial gestalt, excessive bruising and, sometimes, major complications due to visceral and vascular fragility." }, { "id": "MONDO:0009161", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009161", "name": "EDS VIIC", "description": "" }, { "id": "MONDO:0009161", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009161", "name": "Ehlers-Danlos syndrome type 7C", "description": "" }, { "id": "MONDO:0009161", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009161", "name": "Ehlers-Danlos syndrome, dermatosparaxis type", "description": "" }, { "id": "MONDO:0009161", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009161", "name": "EDS 7C", "description": "" }, { "id": "MONDO:0009161", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009161", "name": "EDS7C", "description": "" }, { "id": "MONDO:0009161", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009161", "name": "EDSDERMS", "description": "" }, { "id": "MONDO:0009161", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009161", "name": "Ehlers-Danlos syndrome type 7C (formerly)", "description": "" }, { "id": "MONDO:0009161", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009161", "name": "Ehlers-Danlos syndrome, type VII, autosomal recessive", "description": "" }, { "id": "MONDO:0009161", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009161", "name": "dEDS", "description": "" }, { "id": "MONDO:0009161", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009161", "name": "dermatosparaxis", "description": "" }, { "id": "MONDO:0009161", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009161", "name": "dermatosparaxis EDS", "description": "" }, { "id": "MONDO:0009161", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009161", "name": "dermatosparaxis Ehlers-Danlos syndrome", "description": "" }, { "id": "MIM:225410", "resource": "MIM", "url": "https://www.omim.org/entry/225410", "name": "Ehlers-Danlos syndrome, dermatosparaxis type", "description": "Ehlers-Danlos syndrome, dermatosparaxis type" } ], "unlinked_id_list": [], "evidence": [ { "id": "0080733", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080733" } ] }, { "disease_id": "DOID:13359", "recommended_name": { "id": "DOID:13359", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13359", "name": "Ehlers-Danlos syndrome", "description": "A collagen disease that is characterized by extremely flexible joints, elastic skin, and excessive bruising caused by a heritable defect in collagen synthesis, which leads to marked healing difficulties. EDS has five cardinal signs, which may be present to some degree in all of the subtypes. These five cardinal signs are skin fragility, blood vessel fragility, skin hyperelasticity, joint hypermobility, and characteristic subcutaneous nodules." }, "synonyms": [ { "id": "DOID:13359", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13359", "name": "Cutis hyperelastica", "description": "" }, { "id": "DOID:13359", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13359", "name": "elastic skin", "description": "" }, { "id": "MONDO:0019567", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019567", "name": "Ehlers-Danlos syndrome, classic type, 1", "description": "Any Ehlers-Danlos syndrome in which the cause of the disease is a mutation in the COL5A1 gene." }, { "id": "MONDO:0019567", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019567", "name": "EDS I", "description": "" }, { "id": "MONDO:0019567", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019567", "name": "EDSCL1", "description": "" }, { "id": "MONDO:0019567", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019567", "name": "Ehlers-Danlos syndrome, classic type, 1", "description": "" }, { "id": "MONDO:0019567", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019567", "name": "Ehlers-Danlos syndrome, type 1", "description": "" }, { "id": "MONDO:0019567", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019567", "name": "Ehlers-Danlos syndrome, type I", "description": "" }, { "id": "MONDO:0019567", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019567", "name": "type I Ehlers-Danlos syndrome", "description": "" }, { "id": "MIM:130000", "resource": "MIM", "url": "https://www.omim.org/entry/130000", "name": "Ehlers-Danlos syndrome, classic type, 1", "description": "Ehlers-Danlos syndrome, classic type, 1" } ], "unlinked_id_list": [], "evidence": [ { "id": "13359", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13359" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Danio rerio", "taxid": 7955, "evidence": [ { "database": "UniProtKB", "id": "A0A0R4ISF7", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ISF7" } ], "common_name": "Zebrafish", "glygen_name": "Zebrafish", "reference_species": "Danio rerio [7955]" } ], "gene": [ { "name": "adamts2a", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ISF7", "locus": {} } ], "crossref": [ { "id": "ZFIN:ZDB-GENE-070816-3", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-070816-3", "database": "AGR", "categories": [ "Protein Classification" ] }, { "id": "ENSDARG00000075930", "url": "https://bgee.org/?page=gene&gene_id=ENSDARG00000075930", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd04273", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04273", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "571682", "url": "https://www.ncbi.nlm.nih.gov/gene/571682", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000884", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000884", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001590", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001590", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002870", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002870", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010294", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010294", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013273", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013273", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024079", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024079", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036383", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036383", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041645", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041645", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045371", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045371", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050439", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050439", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dre:571682", "url": "https://www.genome.jp/dbget-bin/www_bget?dre:571682", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DGEMNNC", "url": "https://omabrowser.org/oma/group/DGEMNNC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A0R4ISF7", "url": "https://www.orthodb.org/?gene=A0A0R4ISF7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13723", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13723", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13723:SF141", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13723:SF141", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00090", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00090", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF01421", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01421", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF01562", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01562", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF05986", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF05986", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF17771", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17771", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF19030", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19030", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF19236", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19236", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "XP_700384", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_700384", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A0R4ISF7", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ISF7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0R4ISF7-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ISF7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "ZDB-GENE-070816-3", "url": "https://zfin.org/ZDB-GENE-070816-3", "database": "ZFIN", "categories": [ "Protein", "Organism-specific" ] } ], "sequence": { "sequence": "MDVTPGCAFFIFFLHFQRADTLYIANSIDSLQHVLREYGLVRPVSVDADGHFLTHAVSASRLSGQGSHRRRRRQANQQGETDHLRETLFYNVTVYGQEFHLRLRLNSRLVAPGAKVEWLEDDNQTHSEPLLPSDCLYVGYVTNVQDTSVAISNCDGLAGMIRAGQEEFFIEPLERGGDMTGEEEGGPGRHHIVYRSSDIKKPAVNQPADFHPRGSPLGGLAALELLPQHVKKKINSRARRETYEDEIFNIEVLLGVDCSVVMFHGREHIQKYLLTLMNIVNEIYQDSTLGAHINVVLVRIMMLCSSKSMGLIELGNASQSLENVCRWAFLQQKEDKNDAEYHDHAIFLTRQEFGPTGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQANECGDEVPMGSIMAPLVQAAFHRFHWSRCSQQELRRYLNTYDCLRDDPFDHEWPTLPQLPGLQYSMDEQCRFDFGMGYMMCTAYSTYDPCKQLWCSHPENPFFCKTKKGPPIDGTKCASGKNCFKGHCIKLTPDILRLDGHWGQWTKFGSCSRTCGGGVRFRTRECNNPVPANGGRTCYGNNYEFQLCNTEECAEALVDFREEQCKMWDPHFEHEGNKHHWLPYEHSEPDERCQLYCQSKETGDVVSMKRMVHDGTRCSYKDPYSVCVRGECEKVGCDNVIASELEDDKCGVCGGDNSTCKIVKGNFTRSTRKPGFLKILEIPRGARHIQIHEFKGTPHILAVKNQATDHLFLNDEGDFPESRTVIEKGVAWEYTNNDDMETVQTTGPLRYGVLIMVQSHSISKVTISYKYILPEDPLSSMENTLPQDDTIYFEWALRKWSHCSKPCGGGKQYTRFGCRRKSDGKMVHRTLCANIPKPRAISRACNQKECSEPIWVTGEWEECSKSCGKTGSQTRPVRCVRPELDGSYKAINAKYCNDDRPEGRRPCNRQLCPAHWRTGPWSQCSVSCGNGTQERQVMCSTPDNAIGICMDTKPQSVRSCLPAPCPNDRGNFLIQWLSRADPEFPAPKISSRSRCKGDKSVFCRMEVLSMYCSNPGYRQMCCKSCSETNYTSQFNLTRPWTYTTATPPKTPIRTTLLFRTSQKPSTTTTPSISRWTDISPTSATTKTLKQTTTITFTTGAFTKHPDSFDYEEESSGSFYEDETWSSVSESESSEFISSSSKPWSTTPQYTTTPENENIEMTLLTTPQPNVTATTSPPAIVSLHLSEDKKENNSIDVSYRIVSPNEVALNHFVPRKRVSFREKTQNKRIQELLAEKRRQDFLLQRLKRKPGD", "length": 1295, "header": "tr|A0A0R4ISF7-1|A0A0R4ISF7_DANRE Isoform 1 of ADAM metallopeptidase with thrombospondin type 1 motif, 2 OS=Danio rerio OX=7955 GN=adamts2a PE=4 SV=2 CANONICAL=A0A0R4ISF7-1" }, "isoforms": [ { "isoform_ac": "A0A0R4ISF7-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ISF7/entry#A0A0R4ISF7-1", "sequence": { "sequence": "MDVTPGCAFFIFFLHFQRADTLYIANSIDSLQHVLREYGLVRPVSVDADGHFLTHAVSASRLSGQGSHRRRRRQANQQGETDHLRETLFYNVTVYGQEFHLRLRLNSRLVAPGAKVEWLEDDNQTHSEPLLPSDCLYVGYVTNVQDTSVAISNCDGLAGMIRAGQEEFFIEPLERGGDMTGEEEGGPGRHHIVYRSSDIKKPAVNQPADFHPRGSPLGGLAALELLPQHVKKKINSRARRETYEDEIFNIEVLLGVDCSVVMFHGREHIQKYLLTLMNIVNEIYQDSTLGAHINVVLVRIMMLCSSKSMGLIELGNASQSLENVCRWAFLQQKEDKNDAEYHDHAIFLTRQEFGPTGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQANECGDEVPMGSIMAPLVQAAFHRFHWSRCSQQELRRYLNTYDCLRDDPFDHEWPTLPQLPGLQYSMDEQCRFDFGMGYMMCTAYSTYDPCKQLWCSHPENPFFCKTKKGPPIDGTKCASGKNCFKGHCIKLTPDILRLDGHWGQWTKFGSCSRTCGGGVRFRTRECNNPVPANGGRTCYGNNYEFQLCNTEECAEALVDFREEQCKMWDPHFEHEGNKHHWLPYEHSEPDERCQLYCQSKETGDVVSMKRMVHDGTRCSYKDPYSVCVRGECEKVGCDNVIASELEDDKCGVCGGDNSTCKIVKGNFTRSTRKPGFLKILEIPRGARHIQIHEFKGTPHILAVKNQATDHLFLNDEGDFPESRTVIEKGVAWEYTNNDDMETVQTTGPLRYGVLIMVQSHSISKVTISYKYILPEDPLSSMENTLPQDDTIYFEWALRKWSHCSKPCGGGKQYTRFGCRRKSDGKMVHRTLCANIPKPRAISRACNQKECSEPIWVTGEWEECSKSCGKTGSQTRPVRCVRPELDGSYKAINAKYCNDDRPEGRRPCNRQLCPAHWRTGPWSQCSVSCGNGTQERQVMCSTPDNAIGICMDTKPQSVRSCLPAPCPNDRGNFLIQWLSRADPEFPAPKISSRSRCKGDKSVFCRMEVLSMYCSNPGYRQMCCKSCSETNYTSQFNLTRPWTYTTATPPKTPIRTTLLFRTSQKPSTTTTPSISRWTDISPTSATTKTLKQTTTITFTTGAFTKHPDSFDYEEESSGSFYEDETWSSVSESESSEFISSSSKPWSTTPQYTTTPENENIEMTLLTTPQPNVTATTSPPAIVSLHLSEDKKENNSIDVSYRIVSPNEVALNHFVPRKRVSFREKTQNKRIQELLAEKRRQDFLLQRLKRKPGD", "length": 1295, "header": "tr|A0A0R4ISF7-1|A0A0R4ISF7_DANRE Isoform 1 of ADAM metallopeptidase with thrombospondin type 1 motif, 2 OS=Danio rerio OX=7955 GN=adamts2a PE=4 SV=2 CANONICAL=A0A0R4ISF7-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "start_pos": 1125, "start_aa": "Thr", "end_pos": 1125, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1125", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "00000000000000001000.00000000001000.0.xxxxx" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "The zebrafish reference genome sequence and its relationship to the human genome.", "journal": "Nature", "date": "2013", "authors": "Howe Kerstin, Clark Matthew D, Torroja Carlos F, Torrance James, Berthelot Camille, Muffato Matthieu, Collins John E, Humphray Sean, McLaren Karen, Matthews Lucy, McLaren Stuart, Sealy Ian, Caccamo Mario, Churcher Carol, Scott Carol, Barrett Jeffrey C, Koch Romke, Rauch Gerd-J\u00f6rg, White Simon, Chow William, Kilian Britt, Quintais Leonor T, Guerra-Assun\u00e7\u00e3o Jos\u00e9 A, Zhou Yi, Gu Yong, Yen Jennifer, Vogel Jan-Hinnerk, Eyre Tina, Redmond Seth, Banerjee Ruby, Chi Jianxiang, Fu Beiyuan, Langley Elizabeth, Maguire Sean F, Laird Gavin K, Lloyd David, Kenyon Emma, Donaldson Sarah, Sehra Harminder, Almeida-King Jeff, Loveland Jane, Trevanion Stephen, Jones Matt, Quail Mike, Willey Dave, Hunt Adrienne, Burton John, Sims Sarah, McLay Kirsten, Plumb Bob, Davis Joy, Clee Chris, Oliver Karen, Clark Richard, Riddle Clare, Elliot David, Eliott David, Threadgold Glen, Harden Glenn, Ware Darren, Begum Sharmin, Mortimore Beverley, Mortimer Beverly, Kerry Giselle, Heath Paul, Phillimore Benjamin, Tracey Alan, Corby Nicole, Dunn Matthew, Johnson Christopher, Wood Jonathan, Clark Susan, Pelan Sarah, Griffiths Guy, Smith Michelle, Glithero Rebecca, Howden Philip, Barker Nicholas, Lloyd Christine, Stevens Christopher, Harley Joanna, Holt Karen, Panagiotidis Georgios, Lovell Jamieson, Beasley Helen, Henderson Carl, Gordon Daria, Auger Katherine, Wright Deborah, Collins Joanna, Raisen Claire, Dyer Lauren, Leung Kenric, Robertson Lauren, Ambridge Kirsty, Leongamornlert Daniel, McGuire Sarah, Gilderthorp Ruth, Griffiths Coline, Manthravadi Deepa, Nichol Sarah, Barker Gary, Whitehead Siobhan, Kay Michael, Brown Jacqueline, Murnane Clare, Gray Emma, Humphries Matthew, Sycamore Neil, Barker Darren, Saunders David, Wallis Justene, Babbage Anne, Hammond Sian, Mashreghi-Mohammadi Maryam, Barr Lucy, Martin Sancha, Wray Paul, Ellington Andrew, Matthews Nicholas, Ellwood Matthew, Woodmansey Rebecca, Clark Graham, Cooper James D, Cooper James, Tromans Anthony, Grafham Darren, Skuce Carl, Pandian Richard, Andrews Robert, Harrison Elliot, Kimberley Andrew, Garnett Jane, Fosker Nigel, Hall Rebekah, Garner Patrick, Kelly Daniel, Bird Christine, Palmer Sophie, Gehring Ines, Berger Andrea, Dooley Christopher M, Ersan-\u00dcr\u00fcn Z\u00fcbeyde, Eser Cigdem, Geiger Horst, Geisler Maria, Karotki Lena, Kirn Anette, Konantz Judith, Konantz Martina, Oberl\u00e4nder Martina, Rudolph-Geiger Silke, Teucke Mathias, Lanz Christa, Raddatz G\u00fcnter, Osoegawa Kazutoyo, Zhu Baoli, Rapp Amanda, Widaa Sara, Langford Cordelia, Yang Fengtang, Schuster Stephan C, Carter Nigel P, Harrow Jennifer, Ning Zemin, Herrero Javier, Searle Steve M J, Enright Anton, Geisler Robert, Plasterk Ronald H A, Lee Charles, Westerfield Monte, de Jong Pieter J, Zon Leonard I, Postlethwait John H, N\u00fcsslein-Volhard Christiane, Hubbard Tim J P, Roest Crollius Hugues, Rogers Jane, Stemple Derek L", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4ISF7", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ISF7" } ], "reference": [ { "type": "PubMed", "id": "23594743", "url": "https://glygen.org/publication/PubMed/23594743" } ] } ], "pathway": [ { "id": "dre:571682", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?dre:571682", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZTE7-1", "protein_name": "ADAM metallopeptidase with thrombospondin type 1 motif, 2", "gene_name": "Adamts2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDPPAGAARCLLCPALLLLLLLPPPPLLLLPPPPASARLVAATETPGGPPGYGAERILAVPVRTDAQGRLVSHVVSLETARAGVRARRAAPVQTSGLPGGAEQDPGGRLFYNLTVFGRDLHLRLRPNARLVAPGATVEWQGETGDTRVEPLLGTCLYVGDVADLPKTSSVALSNCDGLAGLIRMEEEEFFIEPLEKGQTDQEAEQGRVHVVYRRPPTPKPPPVGGPQALDTGASQGNLDSLSRALGVLEERINSSRRRVRRHATDDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSHAKSMSLIEIGNPSQSLENVCRWAYLQQKPDTDHDEYHDHAIFLTRQDFGPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHSYDCLRDDPFAHDWPALPQLPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTMCAPGKHCFKGHCIWLTPDILKRDGNWGAWTPFGSCSRTCGTGVKFRTRQCDSPHPANGGRTCSGLAYDFQLCNPQDCPNSLADFREEQCRQWDLYFEHGDAQHHWLPHEHRDAKERCHLYCESKETGEVVSMKRMVHDGTRCSYKDAFSLCVRGDCRKVGCDGVIGSRKQEDKCGVCGGDNTHCKVVKGTFTRSPRKQDYIKMFEIPAGARHLLIQETDTTSHHLSVKNLETGKFILNEENHLDPNSRSFIAMGVEWEYRNEDERETLQTIGPLHGTITVLVIPEGDARISLTYKYMIHEDSLNVDDNNVLEDDSVRHEWALKKWSPCSKPCGGGSQFTKYGCRRRLDSKMVHRAFCSALAKPKAIRRACNPQECSQPVWVTGEWEPCTQSCGRTGMQVRSVRCIQPLHNNTTRSVHTKHCNDHRPESRRACNRELCPGRWRAGSWSQCSVTCGNGTQERPVLCRTADDNFGVCQEERPETARICRLAPCPRNSSDPSKKSYVVQWLSRPDPDSPIQKISSKDQCQGDKSMFCRMEVLSRYCSIPSYNKLCCKSCSPNLGHAEDRGSEPPPGKHNDIDVFMPTLPGPTVATQVQPSPGPPLEAPLNVSIANATEDHPETNAVDVPYKIHGVDEEAQSPNLIPRRPSPYVKTRNQRIQELINAAQRKEKPGKF", "length": 1212 }, "evidence": [ { "id": "HGNC:218", "url": "https://alliancegenome.org/gene/HGNC:218#orthology", "database": "AGR" }, { "id": "MGI:1347356", "url": "https://alliancegenome.org/gene/MGI:1347356#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O95450-1", "protein_name": "A disintegrin and metalloproteinase with thrombospondin motifs 2", "gene_name": "ADAMTS2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDPPAGAARRLLCPALLLLLLLLPPPLLPPPPPPANARLAAAADPPGGPLGHGAERILAVPVRTDAQGRLVSHVVSAATSRAGVRARRAAPVRTPSFPGGNEEEPGSHLFYNVTVFGRDLHLRLRPNARLVAPGATMEWQGEKGTTRVEPLLGSCLYVGDVAGLAEASSVALSNCDGLAGLIRMEEEEFFIEPLEKGLAAQEAEQGRVHVVYRRPPTSPPLGGPQALDTGASLDSLDSLSRALGVLEEHANSSRRRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDFGPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHSYDCLLDDPFAHDWPALPQLPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTMCAPGKHCFKGHCIWLTPDILKRDGSWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDFQLCSRQDCPDSLADFREEQCRQWDLYFEHGDAQHHWLPHEHRDAKERCHLYCESRETGEVVSMKRMVHDGTRCSYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVKGTFTRSPKKHGYIKMFEIPAGARHLLIQEVDATSHHLAVKNLETGKFILNEENDVDASSKTFIAMGVEWEYRDEDGRETLQTMGPLHGTITVLVIPVGDTRVSLTYKYMIHEDSLNVDDNNVLEEDSVVYEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQERPVLCRTADDSFGICQEERPETARTCRLGPCPRNISDPSKKSYVVQWLSRPDPDSPIRKISSKGHCQGDKSIFCRMEVLSRYCSIPGYNKLCCKSCNLYNNLTNVEGRIEPPPGKHNDIDVFMPTLPVPTVAMEVRPSPSTPLEVPLNASSTNATEDHPETNAVDEPYKIHGLEDEVQPPNLIPRRPSPYEKTRNQRIQELIDEMRKKEMLGKF", "length": 1211 }, "evidence": [ { "id": "HGNC:218", "url": "https://alliancegenome.org/gene/HGNC:218#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-070816-3", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-070816-3#orthology", "database": "AGR" }, { "id": "MGI:1347356", "url": "https://alliancegenome.org/gene/MGI:1347356#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8C9W3-1", "protein_name": "A disintegrin and metalloproteinase with thrombospondin motifs 2", "gene_name": "Adamts2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDPPAGAARRLLCPALLLLLLPPPPLLLLPPPPASVRLVAATEPPGGPPGQGAERILAVPVRTDAQGRLVSHVVSLETAGAGVRARRAALDQTSGLPGGAAQDPGGRLFYNLTVFGRDLHLRLRPNARLVAPGATVEWQGETGDTRVEPLLGSCLYVGDVADLPKASSVALSNCDGLAGLIRMEEEEFFIEPLEKGQTDQEAEQGRVHVVYRRPPTPKPPPVSEPQALDTGVSQGNLDSLSRALGVLEERINSSRRRVRRHATDDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSHAKSMSLIEIGNPSQSLENVCRWAYLQQKPDTDHDEYHDHAIFLTRQDFGPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHSYDCLRDDPFAHDWPALPQLPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTMCAPGKHCFKGHCIWLTPDILKRDGNWGAWTPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDFQLCNPQDCPNSLADFREEQCQQWDLYFEHGDVQHHWLPHEHRDAKERCHLYCESKETGEVVSMKRMVHDGTRCSYKDAFSLCVRGDCRKVGCDGVIGSRKQEDKCGVCGGDNTHCKVVKGTFTRSPRKQDYIKMFEIPAGARHLLIQEADTTSHHLSVKNLETGKFILNEENHLDPNSRSFIAMGVEWEYRNEDERETLQTIGPLHGTITVLVIPEGDTRISLTYKYMIHEDSLNVDDNNVLEDDAVRHEWALKKWSPCSKPCGGGSQFTKYGCRRRLDSKMVHRAFCSALAKPKAIRRACNPQECSQPVWVTGEWEPCTQSCGRTGMQVRSVRCIQPLHNNTTRSVHTKHCNDHRPESRRACNRELCPGRWRAGSWSQCSVTCGNGTQERPVLCRTADDNFGVCREERPETARICRLAPCPRNGSDPSKKSYVVQWLSRPDPDSPIQKISSKDQCQGDKSMFCRMEVLSRYCSIPSYNKLCCKSCNPPRNLSNTEDGGVEPPPGKHNDIDVFMPTLPGPTVATQVQPSPGPPLEAPLNVSSTNATEDHPETNAVDVPYKIHGVDEEVPSPNLIPRRPSLYVKTRNQRIQELINAVQRKEKPGKF", "length": 1213 }, "evidence": [ { "id": "HGNC:218", "url": "https://alliancegenome.org/gene/HGNC:218#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-070816-3", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-070816-3#orthology", "database": "AGR" }, { "id": "MGI:1347356", "url": "https://alliancegenome.org/gene/MGI:1347356#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9W1Z6-1", "protein_name": "Stall, isoform C", "gene_name": "stl", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MTVAAIGSNRHRRLALIVLTTLWLLIGASSSSSSTSSTNPKSVNIELRRKRSLHYNGIELDKNTLVGHLREHERALIFGSRSPEEAPEFKLVHLAQQRPEEQQRLEERKRPGEAEQHGGNPHQRRQRRSLPSEDGNGPLPPEEEEQEAGEDVEARLQLQQSPQLIDDAFIFIRRTENGTQFVEHSPQLLKRLERCFYRSPAAALDLCEPGNVRGVFQQNGSDLVIHPLPARFGTGTHVLYQARVDKSGGGYSEASSRRTASPLDSQLQFEPDAEEFNEPRRRLRAQSQLQSPLRLRFQPRHHHPHQHHQQRRRRYIGDAPRSRWSDIPEELFIETAIFVDSDLYAHMQKNFPTNTESKVVSFLLAMINGVQLLYHHPTLGRRINFVLKRLEIWKSWDPPGLVRSRDVENYLNSFCKWQEKLNPFSDADPLHYDHALVLTGLDLVTYDKGKANSQVVGMATVKGMCTSIYSCTINEAKHFESVFVVAHEIGHNLGMRHDAKEISCDPTMHIMSPKLGSGKVTWSKCSRTYLEDFLMDPQAECLFDRDSFAGPWDHTAGGRLPGERFNANQQCMLRFGKNFMQASTQSKMEICRDLHCRQDGLPWTSHPALEGTECGPNMWCRGGTCEARSSKQGSYSALKSWPPEHIPEATHEKIIRHEPNRIPPLLHDYNPMDNELPGSPSNWGEWSEPSACESGCLYGQSRRLLEGSTGLRTLNRSCLNFPSRCIGRDRRFVTCNTPQCHKVPVQTINDFATQVCMQARKSDPELTGEGQQLPSTLDASCKIFCRTRTNGTKSRRWTFPDGTTCKAKQHNPEDITYCISGRCERFSCDNSTSNFFKMDSSFCEARSVRPTRDSSDQESRQQTNRQRYAERQEGKPQKNHYENEVAKRPSYGQGNHINAPASPYKRRNYHKPYPPEIPRPPPPASASLIALDRSSSSESEWVAHPGCHSNCMTDSKGVQGVTSRLTGVESIQLCSYRIQPCERLQTAAEYAEQTCARYRQKVRGLSGHGAQISASIDEPDRSCRVGCQDEFIKYRYYLVNGRNGHFPPGTRCSPVGKRYCVYGRCLEFGDDDLPLDKTHISLGQLRTRRKRSSISNDLFNITEIFIKPSHSDISAENIEFTQPIHVSADELSSKSR", "length": 1136 }, "evidence": [ { "id": "HGNC:218", "url": "https://alliancegenome.org/gene/HGNC:218#orthology", "database": "AGR" }, { "id": "MGI:1347356", "url": "https://alliancegenome.org/gene/MGI:1347356#orthology", "database": "AGR" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metalloendopeptidase activity", "id": "GO:0004222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004222", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4ISF7", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ISF7" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4ISF7", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ISF7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4ISF7", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ISF7" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4ISF7", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ISF7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4ISF7", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ISF7" } ], "pmid": "" }, { "name": "extracellular matrix organization", "id": "GO:0030198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030198", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4ISF7", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ISF7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1073, "end_pos": 1075, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1079, "end_pos": 1081, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1213, "end_pos": 1215, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1235, "end_pos": 1237, "annotation": "n_glycosylation_sequon" }, { "start_pos": 123, "end_pos": 125, "annotation": "n_glycosylation_sequon" }, { "start_pos": 316, "end_pos": 318, "annotation": "n_glycosylation_sequon" }, { "start_pos": 701, "end_pos": 703, "annotation": "n_glycosylation_sequon" }, { "start_pos": 710, "end_pos": 712, "annotation": "n_glycosylation_sequon" }, { "start_pos": 91, "end_pos": 93, "annotation": "n_glycosylation_sequon" }, { "start_pos": 974, "end_pos": 976, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.agr", "label": "AGR Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 1125 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1073, "end_pos": 1075 }, { "start_pos": 1079, "end_pos": 1081 }, { "start_pos": 1213, "end_pos": 1215 }, { "start_pos": 1235, "end_pos": 1237 }, { "start_pos": 123, "end_pos": 125 }, { "start_pos": 316, "end_pos": 318 }, { "start_pos": 701, "end_pos": 703 }, { "start_pos": 710, "end_pos": 712 }, { "start_pos": 91, "end_pos": 93 }, { "start_pos": 974, "end_pos": 976 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": 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}, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }