{ "uniprot_canonical_ac": "A0A0R4IS83-1", "uniprot_ac": "A0A0R4IS83", "uniprot_id": "A0A0R4IS83_DANRE", "mass": { "chemical_mass": 87516.0, "monoisotopic_mass": 87516.0 }, "refseq": { "ac": "XP_009290066", "name": "periostin, osteoblast specific factor b isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009290066" }, "gene_names": [ { "name": "postnb", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IS83", "id": "A0A0R4IS83" }, { "name": "PN", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IS83", "id": "A0A0R4IS83" }, { "name": "fa99h07; pn; postn; wu:fa99h07; wu:fc70f09; zgc:153873", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009290066", "id": "XP_009290066" }, { "name": "fa99h07", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IS83", "id": "A0A0R4IS83" }, { "name": "pn", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IS83", "id": "A0A0R4IS83" }, { "name": "postnb", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009290066", "id": "XP_009290066" }, { "name": "postn", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IS83", "id": "A0A0R4IS83" }, { "name": "wu:fa99h07", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IS83", "id": "A0A0R4IS83" }, { "name": "wu:fc70f09", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IS83", "id": "A0A0R4IS83" }, { "name": "zgc:153873", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IS83", "id": "A0A0R4IS83" } ], "protein_names": [ { "name": "Periostin", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IS83/entry#names_and_taxonomy", "id": "A0A0R4IS83" }, { "name": "Osteoblast-specific factor 2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IS83/entry#names_and_taxonomy", "id": "A0A0R4IS83" }, { "name": "periostin, osteoblast specific factor b isoform X1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009290066", "id": "XP_009290066" } ], "function": [ { "annotation": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length.", "evidence": [ { "database": "RefSeq", "id": "XP_009290066", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009290066" } ] }, { "annotation": "Induces cell attachment and spreading and plays a role in cell adhesion. Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX.", "evidence": [ { "database": "UniProtKB", "id": "A0AB32T3F9", "url": "https://www.uniprot.org/uniprotkb/A0AB32T3F9#function" }, { "database": "UniProtKB", "id": "ARBA00058492", "url": "https://www.uniprot.org/uniprotkb/ARBA00058492#function" }, { "database": "UniProtKB", "id": "A0A0R4IS83", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IS83#function" }, { "database": "UniProtKB", "id": "A0A0R4IPF4", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IPF4#function" }, { "database": "UniProtKB", "id": "Q75U66", "url": "https://www.uniprot.org/uniprotkb/Q75U66#function" }, { "database": "UniProtKB", "id": "A0JMK0", "url": "https://www.uniprot.org/uniprotkb/A0JMK0#function" } ] } ], "disease": [ { "disease_id": "DOID:0080010", "recommended_name": { "id": "DOID:0080010", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080010", "name": "bone structure disease", "description": "A bone disease that has_material_basis_in an abnormality in the location or function of the skeletal structure." }, "synonyms": [], "unlinked_id_list": [ "DOID:0080007" ], "evidence": [ { "id": "0080010", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080010" } ] }, { "disease_id": "DOID:1474", "recommended_name": { "id": "DOID:1474", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1474", "name": "aggressive periodontitis", "description": "A periodontitis that is characterized by rapid attachment loss and bone destruction in the presence of little local factors such as dental plaque and dental calculus resulting in inflammation and a loss of periodontium." }, "synonyms": [ { "id": "DOID:1474", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1474", "name": "juvenile periodontitis", "description": "" }, { "id": "MONDO:0008226", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008226", "name": "periodontitis, aggressive 1", "description": "A localized aggressive periodontitis, formerly called localized juvenile periodontitis. It is a destructive form of periodontitis characterized by ALVEOLAR BONE LOSS of the MOLARS and INCISORS. Inflammation and loss of PERIODONTIUM that is characterized by rapid attachment loss and bone destruction in the presence of little local factors such as DENTAL PLAQUE and DENTAL CALCULUS. This highly destructive form of periodontitis often occurs in young people and was called early-onset periodontitis, but this disease also appears in old people." }, { "id": "MONDO:0008226", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008226", "name": "juvenile periodontitis", "description": "" }, { "id": "MONDO:0008226", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008226", "name": "periodontitis 1, juvenile", "description": "" }, { "id": "MONDO:0008226", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008226", "name": "periodontitis, aggressive, type 1", "description": "" }, { "id": "MONDO:0008226", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008226", "name": "periodontitis, aggressive, 1", "description": "" }, { "id": "MONDO:0008226", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008226", "name": "periodontitis, juvenile", "description": "" }, { "id": "MONDO:0008226", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008226", "name": "periodontitis, prepubertal", "description": "" }, { "id": "MONDO:0012051", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012051", "name": "periodontitis, aggressive, 2", "description": "" }, { "id": "MONDO:0012051", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012051", "name": "periodontitis, aggressive, 2", "description": "" }, { "id": "MONDO:0012051", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012051", "name": "periodontitis, aggressive, type 2", "description": "" }, { "id": "MIM:170650", "resource": "MIM", "url": "https://www.omim.org/entry/170650", "name": "Periodontititis, aggressive, 1", "description": "Periodontititis, aggressive, 1" } ], "unlinked_id_list": [], "evidence": [ { "id": "1474", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1474" } ] }, { "disease_id": "DOID:6000", "recommended_name": { "id": "DOID:6000", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:6000", "name": "congestive heart failure", "description": "A heart disease that is characterized by any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body." }, "synonyms": [ { "id": "DOID:6000", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:6000", "name": "CHF", "description": "" }, { "id": "DOID:6000", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:6000", "name": "Cardiac Failure Congestive", "description": "" }, { "id": "DOID:6000", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:6000", "name": "Congestive heart disease", "description": "" }, { "id": "DOID:6000", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:6000", "name": "Weak heart", "description": "" } ], "unlinked_id_list": [ "DOID:12326" ], "evidence": [ { "id": "6000", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:6000" } ] }, { "disease_id": "DOID:7693", "recommended_name": { "id": "DOID:7693", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:7693", "name": "abdominal aortic aneurysm", "description": "An aortic aneurysm that is located_in the abdominal aorta." }, "synonyms": [ { "id": "DOID:7693", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:7693", "name": "AORTIC ANEURYSM, FAMILIAL ABDOMINAL 1", "description": "" }, { "id": "MONDO:0012343", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012343", "name": "aortic aneurysm, familial abdominal, 2", "description": "" }, { "id": "MONDO:0012343", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012343", "name": "AAA2", "description": "" }, { "id": "MONDO:0012343", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012343", "name": "aortic aneurysm, familial abdominal 2", "description": "" }, { "id": "MONDO:0012343", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012343", "name": "aortic aneurysm, familial abdominal, 2", "description": "" }, { "id": "MONDO:0024521", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024521", "name": "aortic aneurysm, familial abdominal, 1", "description": "" }, { "id": "MONDO:0024521", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024521", "name": "AAA1", "description": "" }, { "id": "MONDO:0024521", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024521", "name": "aortic aneurysm, familial abdominal 1", "description": "" }, { "id": "MONDO:0024521", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024521", "name": "aortic aneurysm, familial abdominal, 1", "description": "" }, { "id": "MONDO:0024521", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024521", "name": "abdominal aortic aneurysm", "description": "" }, { "id": "MONDO:0024521", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024521", "name": "aneurysm, abdominal aortic", "description": "" }, { "id": "MONDO:0013716", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013716", "name": "aortic aneurysm, familial abdominal, 4", "description": "" }, { "id": "MONDO:0013716", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013716", "name": "AAA4", "description": "" }, { "id": "MONDO:0013716", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013716", "name": "aortic aneurysm, familial abdominal, 4", "description": "" }, { "id": "MONDO:0012751", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012751", "name": "aortic aneurysm, familial abdominal, 3", "description": "" }, { "id": "MONDO:0012751", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012751", "name": "AAA3", "description": "" }, { "id": "MONDO:0012751", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012751", "name": "aneurysm, familial abdominal 3", "description": "" }, { "id": "MONDO:0012751", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012751", "name": "aortic aneurysm, familial abdominal, 3", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "7693", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:7693" } ] }, { "disease_id": "DOID:784", "recommended_name": { "id": "DOID:784", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:784", "name": "chronic kidney disease", "description": "A kidney failure that is characterized by the gradual loss of kidney function." }, "synonyms": [ { "id": "DOID:784", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:784", "name": "CKD", "description": "" }, { "id": "DOID:784", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:784", "name": "CRF", "description": "" }, { "id": "DOID:784", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:784", "name": "chronic kidney failure", "description": "" }, { "id": "DOID:784", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:784", "name": "chronic renal disease", "description": "" }, { "id": "DOID:784", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:784", "name": "chronic renal failure syndrome", "description": "" }, { "id": "DOID:784", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:784", "name": "renal failure - chronic", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "784", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:784" } ] }, { "disease_id": "DOID:90", "recommended_name": { "id": "DOID:90", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:90", "name": "degenerative disc disease", "description": "A bone deterioration disease that has_material_basis_in gradual dehydration and tears located_in intervertebral disc." }, "synonyms": [ { "id": "DOID:90", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:90", "name": "cervical disc degenerative disease", "description": "" }, { "id": "DOID:90", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:90", "name": "intervertebral disc degeneration", "description": "" }, { "id": "DOID:90", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:90", "name": "lumbar disc degeneration", "description": "" }, { "id": "DOID:90", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:90", "name": "vertebral disc disease", "description": "" }, { "id": "MONDO:0011385", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011385", "name": "intervertebral disk degenerative disorder", "description": "Any disease of a degenerative nature that affects the intervertebral disk." }, { "id": "MONDO:0011385", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011385", "name": "IDD", "description": "" }, { "id": "MONDO:0011385", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011385", "name": "degenerative disc disease", "description": "" }, { "id": "MONDO:0011385", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011385", "name": "degenerative disk disease", "description": "" }, { "id": "MONDO:0011385", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011385", "name": "degenerative disorder of intervertebral disc", "description": "" }, { "id": "MONDO:0011385", "resource": 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"https://www.genome.jp/dbget-bin/www_bget?dre:337176", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QWLSYHI", "url": "https://omabrowser.org/oma/group/QWLSYHI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A0R4IPF4", "url": "https://www.orthodb.org/?gene=A0A0R4IPF4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A0R4IS83", "url": "https://www.orthodb.org/?gene=A0A0R4IS83", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0JMK0", "url": "https://www.orthodb.org/?gene=A0JMK0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q75U66", "url": "https://www.orthodb.org/?gene=Q75U66", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10900", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10900", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10900:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10900:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02469", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02469", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "XP_009290066", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009290066", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A0R4IPF4", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IPF4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0R4IPF4-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IPF4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0R4IS83", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IS83", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0R4IS83-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IS83-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AB32T3F9", "url": "https://www.uniprot.org/uniprotkb/A0AB32T3F9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AB32T3F9-1", "url": "https://www.uniprot.org/uniprotkb/A0AB32T3F9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0JMK0", "url": "https://www.uniprot.org/uniprotkb/A0JMK0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0JMK0-1", "url": "https://www.uniprot.org/uniprotkb/A0JMK0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q75U66", "url": "https://www.uniprot.org/uniprotkb/Q75U66", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q75U66-1", "url": "https://www.uniprot.org/uniprotkb/Q75U66-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "ZDB-GENE-030131-9120", "url": "https://zfin.org/ZDB-GENE-030131-9120", "database": "ZFIN", "categories": [ "Protein", "Organism-specific" ] } ], "sequence": { "sequence": "MKLLFAATFALFVLSAFDQADSSAYDKIVAHSRIRAKKQGPNMCALQQVVGTKKKYFSTCRNWYQGAICGKTATVLYECCPGYMELAGQRGCPAVAPIDNVFGTLGLVKAKTTQDYSDISKLRQEIEGAGSYTFFAPSNDAWDLLEAEVRNALVSNVNIELYNALHYHMVNKRLLTKDLKNGMTATSMYNDLSLHINHYSNGVVTVNCARIIHGNQVATNGVVHVIDRVITAVGSTIQDMIEVEDDLSTLSTVATDSGLIDKLGEPGHFTLFAPTNAAFDKLGREVLDRLMKDKKSLQALLNYHLLNSVQCSEAIMAGTSHETLEGSNIEIGCDGDSLTVNGIKMVLKKDIVATNGVIHLIDEVLMPDSAKQVMELVGQSQATFSDMLTELGLSAAMRPQAEYTLLAPVNAAFNDEVMSMDQSFLKIILENHILKNKIVLSQLYNGQRLETLSGKFLRVFVYRTALCIENACLIRGSKEGSNGALHLMKTLISPAESSMFQILVKNGAFKIFLSLMEAAGLTDLLKQEGDFTLFAPTDEAFAGLSERDLTLLKSNGNALKAILLYHFSNGVFIGGGLETGVTNLLKTLQGSNLRVLYANASMLVNTVKVPEPDIMATNGVVHFVRTLLYPEDIPVGSQDLLSLLRRIIRYIQFKFVPGYRYQEIPLTFMRRVITVPGDVTKVTRVIQGEPTITKVTRVIEGAPSVTKVTRVIEGQPSITKVTRVIEGQPSLTKVTRVIEGDPSMTRVIEGPEYSVTSSTDTELYDFGEDSEGITTFIQEGTRRVPPRRVQGGVRRRT", "length": 797, "header": "tr|A0A0R4IS83-1|A0A0R4IS83_DANRE Isoform 1 of Periostin OS=Danio rerio OX=7955 GN=postnb PE=1 SV=1 CANONICAL=A0A0R4IS83-1" }, "isoforms": [ { "isoform_ac": "A0A0R4IPF4-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IS83/entry#A0A0R4IPF4-1", "sequence": { "sequence": "MKLLFAATFALFVLSAFDQADSSAYDKIVAHSRIRAKKQGPNMCALQQVVGTKKKYFSTCRNWYQGAICGKTATVLYECCPGYMELAGQRGCPAVAPIDNVFGTLGLVKAKTTQDYSDISKLRQEIEGAGSYTFFAPSNDAWDLLEAEVRNALVSNVNIELYNALHYHMVNKRLLTKDLKNGMTATSMYNDLSLHINHYSNGVVTVNCARIIHGNQVATNGVVHVIDRVITAVGSTIQDMIEVEDDLSTLSTVATDSGLIDKLGEPGHFTLFAPTNAAFDKLGREVLDRLMKDKKSLQALLNYHLLNSVQCSEAIMAGTSHETLEGSNIEIGCDGDSLTVNGIKMVLKKDIVATNGVIHLIDEVLMPDSAKQVMELVGQSQATFSDMLTELGLSAAMRPQAEYTLLAPVNAAFNDEVMSMDQSFLKIILENHILKNKIVLSQLYNGQRLETLSGKFLRVFVYRTALCIENACLIRGSKEGSNGALHLMKTLISPAESSMFQILVKNGAFKIFLSLMEAAGLTDLLKQEGDFTLFAPTDEAFAGLSERDLTLLKSNGNALKAILLYHFSNGVFIGGGLETGVTNLLKTLQGSNLRVLYANASMLVNTVKVPEPDIMATNGVVHFVRTLLYPEDIPVGSQDLLSLLRRIIRYIQFKFVPGYRYQEIPLTFMRRVITVPGDVTKVTRVIQGEPTITKVTRVIEGAPSVTKVTRVIEGQPSITKVTRVIEGQPSLTKVTRVIEGDPSMTRVIEGPEYSVTSSTDTELYDFGEDSEGITTFIQGGVRRRT", "length": 785, "header": "tr|A0A0R4IPF4-1|A0A0R4IS83_DANRE Computationally mapped isoform of Periostin OS=Danio rerio OX=7955 GN=postnb PE=1 SV=2 CANONICAL=A0A0R4IS83-1" }, "locus": {} }, { "isoform_ac": "A0A0R4IS83-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IS83/entry#A0A0R4IS83-1", "sequence": { "sequence": "MKLLFAATFALFVLSAFDQADSSAYDKIVAHSRIRAKKQGPNMCALQQVVGTKKKYFSTCRNWYQGAICGKTATVLYECCPGYMELAGQRGCPAVAPIDNVFGTLGLVKAKTTQDYSDISKLRQEIEGAGSYTFFAPSNDAWDLLEAEVRNALVSNVNIELYNALHYHMVNKRLLTKDLKNGMTATSMYNDLSLHINHYSNGVVTVNCARIIHGNQVATNGVVHVIDRVITAVGSTIQDMIEVEDDLSTLSTVATDSGLIDKLGEPGHFTLFAPTNAAFDKLGREVLDRLMKDKKSLQALLNYHLLNSVQCSEAIMAGTSHETLEGSNIEIGCDGDSLTVNGIKMVLKKDIVATNGVIHLIDEVLMPDSAKQVMELVGQSQATFSDMLTELGLSAAMRPQAEYTLLAPVNAAFNDEVMSMDQSFLKIILENHILKNKIVLSQLYNGQRLETLSGKFLRVFVYRTALCIENACLIRGSKEGSNGALHLMKTLISPAESSMFQILVKNGAFKIFLSLMEAAGLTDLLKQEGDFTLFAPTDEAFAGLSERDLTLLKSNGNALKAILLYHFSNGVFIGGGLETGVTNLLKTLQGSNLRVLYANASMLVNTVKVPEPDIMATNGVVHFVRTLLYPEDIPVGSQDLLSLLRRIIRYIQFKFVPGYRYQEIPLTFMRRVITVPGDVTKVTRVIQGEPTITKVTRVIEGAPSVTKVTRVIEGQPSITKVTRVIEGQPSLTKVTRVIEGDPSMTRVIEGPEYSVTSSTDTELYDFGEDSEGITTFIQEGTRRVPPRRVQGGVRRRT", "length": 797, "header": "tr|A0A0R4IS83-1|A0A0R4IS83_DANRE Isoform 1 of Periostin OS=Danio rerio OX=7955 GN=postnb PE=1 SV=1 CANONICAL=A0A0R4IS83-1" }, "locus": {} }, { "isoform_ac": "A0AB32T3F9-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IS83/entry#A0AB32T3F9-1", "sequence": { "sequence": "MKLLFAATFALFVLSAFDQADSSAYDKIVAHSRIRAKKQGPNMCALQQVVGTKKKYFSTCRNWYQGAICGKTATVLYECCPGYMELAGQRGCPAVAPIDNVFGTLGLVKAKTTQDYSDISKLRQEIEGAGSYTFFAPSNDAWDLLEAEVRNALVSNVNIELYNALHYHMVNKRLLTKDLKNGMTATSMYNDLSLHINHYSNGVVTVNCARIIHGNQVATNGVVHVIDRVITAVGSTIQDMIEVEDDLSTLSTVATDSGLIDKLGEPGHFTLFAPTNAAFDKLGREVLDRLMKDKKSLQALLNYHLLNSVQCSEAIMAGTSHETLEGSNIEIGCDGDSLTVNGIKMVLKKDIVATNGVIHLIDEVLMPDSAKQVMELVGQSQATFSDMLTELGLSAAMRPQAEYTLLAPVNAAFNDEVMSMDQSFLKIILENHILKNKIVLSQLYNGQRLETLSGKFLRVFVYRTALCIENACLIRGSKEGSNGALHLMKTLISPAESSMFQILVKNGAFKIFLSLMEAAGLTDLLKQEGDFTLFAPTDEAFAGLSERDLTLLKSNGNALKAILLYHFSNGVFIGGGLETGVTNLLKTLQGSNLRVLYANASMLVNTVKVPEPDIMATNGVVHFVRTLLYPEDIPVGSQDLLSLLRRIIRYIQFKFVPGYRYQEIPLTFMRRVITVPGDVTKVTRVIQGEPTITKVTRVIEGAPSVTKVTRVIEGQPSITKVTRVIEGQPSLTKVTRVIEGDPSMTRVIEDFGEDSEGITTFIQGGVRRRT", "length": 770, "header": "tr|A0AB32T3F9-1|A0A0R4IS83_DANRE Computationally mapped isoform of Periostin OS=Danio rerio OX=7955 GN=postnb PE=1 SV=1 CANONICAL=A0A0R4IS83-1" }, "locus": {} }, { "isoform_ac": "A0JMK0-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IS83/entry#A0JMK0-1", "sequence": { "sequence": "MKLLFAATFALFVLSAFDQADSSAYDKIVAHSRIRAKKQGPNMCALQQVVGTKKKYFSTCRNWYQGAICGKKATVLYECCPGYMELAGQRGCPAVAPIDNVFGTLGLVKAKTTQDYSDISKLRQEIEGAGSYTFFAPSNDAWDLLEAEVRNALVSNVNIELYNALHYHMVNKRLLTKDLKNGMTATSMYNDLSLHINHYSNGVVTVNCARIIHGNQVATNGVVHVIDRVITAVGSTIQDMIEVEDDLSTLSTVATDSGLIDKLGEPGHFTLFAPTNAAFDKLGREVLDRLMKDKKSLQALLNYHLLNSVQCSEAIMAGTSHETLEGSNIEIGCDGDSLTVNGIKMVLKKDIVATNGVIHLIDEVLMPDSAKQVMELVGQSQATFSDMLTELGLSAAMRPQAEYTLLAPVNAAFNDEVMSMDQSFLKIILENHILKNKIVLSQLYNGQRLETLSGKFLRVFVYRTALCIENACLIRGSKEGSNGALHLMKTLISPAESSMFQILVKNGAFKIFLSLMEAAGLTDLLKQEGDFTLFAPTDEAFAGLSERDLTLLKSNGNALKAILLYHFSNGVFIGGGLETGVTNLLKTLQGSNLRVLYANASMLVNTVKVPEPDIMATNGVVHFVRTLLYPEDIPVGSQDLLSLLRRIIRYIQFKFVPGYRYQEIPLTFMRRVITVPGDVTKVTRVIQGEPTITKVTRVIEGAPSVTKVTRVIEGQPSITKVTRVIEGQPSLTKVTRVIEGDPSITRVIEGGVRRRT", "length": 756, "header": "tr|A0JMK0-1|A0A0R4IS83_DANRE Computationally mapped isoform of Periostin OS=Danio rerio OX=7955 GN=postnb PE=1 SV=1 CANONICAL=A0A0R4IS83-1" }, "locus": {} }, { "isoform_ac": "Q75U66-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IS83/entry#Q75U66-1", "sequence": { "sequence": "MKLLFAATFALFVLSAFDQADSSAYDKIVAHSRIRAKKQGPNMCALQQVVGTKKKYFSTCRNWYQGAICGKTATVLYECCPGYMELAGQRGCPAVAPIDNVFGTLGLVKAKTTQDYSDISKLRQEIEGAGSYTFFAPSNDAWDLLEAEVRNALVSNVNIELYNALHYHMVNKRLLTKDLKNGMTATSMYNDLSLHINHYSNGVVTVNCARIIHGNQVATNGVVHVIDRVITAVGSTIQDMIEVEDDLSTLSTVATDSGLIDKLGEPGHFTLFAPTNAAFDKLGREVLDRLMKDKKSLQALLNYHLLNSVQCSEAIMAGTSHETLEGSNIEIGCDGDSLTVNGIKMVLKKDIVATNGVIHLIDEVLMPDSAKQVMELVGQSQATFSDMLTELGLSAAMRPQAEYTLLAPVNAAFNDEVMSMDQSFLKIILENHILKNKIVLSQLYNGQRLETLSGKFLRVFVYRTALCIENACLIRGSKEGSNGALHLMKTLISPAESSMFQILVKNGAFKIFLSLMEAAGLTDLLKQEGDFTLFAPTDEAFAGLSERDLTLLKSNGNALKAILLYHFSNGVFIGGGLETGVTNLLKTLQGSNLRVLYANASMLVNTVKVPEPDIMATNGVVHFVRTLLYPEDIPVGSQDLLSLLRRIIRYIQFKFVPGYRYQEIPLTFMRRVITVPGDVTKVTRVIQGEPTITKVTRVIEGAPSVTKVTRVIEGQPSITKVTRVIEGQPSLTKVTRVIEGDPSMTRVIEDFGEDSEGITTFIQEGTRRVPPRRVQGGVRRRT", "length": 782, "header": "tr|Q75U66-1|A0A0R4IS83_DANRE Computationally mapped isoform of Periostin OS=Danio rerio OX=7955 GN=postnb PE=1 SV=1 CANONICAL=A0A0R4IS83-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Zebrafish periostin is required for the adhesion of muscle fiber bundles to the myoseptum and for the differentiation of muscle fibers.", "journal": "Dev. Biol.", "date": "2004", "authors": "Kudo Hisaaki, Amizuka Norio, Araki Kazuo, Inohaya Keiji, Kudo Akira", "evidence": [ { "database": "UniProtKB", "id": "A0JMK0", "url": "https://www.uniprot.org/uniprotkb/A0JMK0" } ], "reference": [ { "type": "PubMed", "id": "15013807", "url": "https://glygen.org/publication/PubMed/15013807" } ] }, { "title": "Screen for genes differentially expressed during regeneration of the zebrafish caudal fin.", "journal": "Dev. Dyn.", "date": "2004", "authors": "Padhi Bhaja K, Joly Lucille, Tellis Patricia, Smith Amanda, Nanjappa Purushothama, Chevrette Mario, Ekker Marc, Akimenko Marie-Andr\u00e9e", "evidence": [ { "database": "UniProtKB", "id": "A0JMK0", "url": "https://www.uniprot.org/uniprotkb/A0JMK0" } ], "reference": [ { "type": "PubMed", "id": "15376328", "url": "https://glygen.org/publication/PubMed/15376328" } ] }, { "title": "Gene expression profiling of zebrafish embryonic retina.", "journal": "Zebrafish", "date": "2005", "authors": "Leung Yuk Fai, Dowling John E", "evidence": [ { "database": "UniProtKB", "id": "A0JMK0", "url": "https://www.uniprot.org/uniprotkb/A0JMK0" } ], "reference": [ { "type": "PubMed", "id": "18248185", "url": "https://glygen.org/publication/PubMed/18248185" } ] }, { "title": "Transcriptomics approach to investigate zebrafish heart regeneration.", "journal": "J Cardiovasc Med (Hagerstown)", "date": "2010", "authors": "Sleep Eduard, Bou\u00e9 St\u00e9phanie, Jopling Chris, Raya Marina, Raya Angel, Izpisua Belmonte Juan Carlos", "evidence": [ { "database": "UniProtKB", "id": "A0JMK0", "url": "https://www.uniprot.org/uniprotkb/A0JMK0" } ], "reference": [ { "type": "PubMed", "id": "20179605", "url": "https://glygen.org/publication/PubMed/20179605" } ] }, { "title": "RNA-Seq analysis in mutant zebrafish reveals role of U1C protein in alternative splicing regulation.", "journal": "EMBO J.", "date": "2011", "authors": "R\u00f6sel Tanja Dorothe, Hung Lee-Hsueh, Medenbach Jan, Donde Katrin, Starke Stefan, Benes Vladimir, R\u00e4tsch Gunnar, Bindereif Albrecht", "evidence": [ { "database": "UniProtKB", "id": "A0JMK0", "url": "https://www.uniprot.org/uniprotkb/A0JMK0" } ], "reference": [ { "type": "PubMed", "id": "21468032", "url": "https://glygen.org/publication/PubMed/21468032" } ] }, { "title": "The zebrafish reference genome sequence and its relationship to the human genome.", "journal": "Nature", "date": "2013", "authors": "Howe Kerstin, Clark Matthew D, Torroja Carlos F, Torrance James, Berthelot Camille, Muffato Matthieu, Collins John E, Humphray Sean, McLaren Karen, Matthews Lucy, McLaren Stuart, Sealy Ian, Caccamo Mario, Churcher Carol, Scott Carol, Barrett Jeffrey C, Koch Romke, Rauch Gerd-J\u00f6rg, White Simon, Chow William, Kilian Britt, Quintais Leonor T, Guerra-Assun\u00e7\u00e3o Jos\u00e9 A, Zhou Yi, Gu Yong, Yen Jennifer, Vogel Jan-Hinnerk, Eyre Tina, Redmond Seth, Banerjee Ruby, Chi Jianxiang, Fu Beiyuan, Langley Elizabeth, Maguire Sean F, Laird Gavin K, Lloyd David, Kenyon Emma, Donaldson Sarah, Sehra Harminder, Almeida-King Jeff, Loveland Jane, Trevanion Stephen, Jones Matt, Quail Mike, Willey Dave, Hunt Adrienne, Burton John, Sims Sarah, McLay Kirsten, Plumb Bob, Davis Joy, Clee Chris, Oliver Karen, Clark Richard, Riddle Clare, Elliot David, Eliott David, Threadgold Glen, Harden Glenn, Ware Darren, Begum Sharmin, Mortimore Beverley, Mortimer Beverly, Kerry Giselle, Heath Paul, Phillimore Benjamin, Tracey Alan, Corby Nicole, Dunn Matthew, Johnson Christopher, Wood Jonathan, Clark Susan, Pelan Sarah, Griffiths Guy, Smith Michelle, Glithero Rebecca, Howden Philip, Barker Nicholas, Lloyd Christine, Stevens Christopher, Harley Joanna, Holt Karen, Panagiotidis Georgios, Lovell Jamieson, Beasley Helen, Henderson Carl, Gordon Daria, Auger Katherine, Wright Deborah, Collins Joanna, Raisen Claire, Dyer Lauren, Leung Kenric, Robertson Lauren, Ambridge Kirsty, Leongamornlert Daniel, McGuire Sarah, Gilderthorp Ruth, Griffiths Coline, Manthravadi Deepa, Nichol Sarah, Barker Gary, Whitehead Siobhan, Kay Michael, Brown Jacqueline, Murnane Clare, Gray Emma, Humphries Matthew, Sycamore Neil, Barker Darren, Saunders David, Wallis Justene, Babbage Anne, Hammond Sian, Mashreghi-Mohammadi Maryam, Barr Lucy, Martin Sancha, Wray Paul, Ellington Andrew, Matthews Nicholas, Ellwood Matthew, Woodmansey Rebecca, Clark Graham, Cooper James D, Cooper James, Tromans Anthony, Grafham Darren, Skuce Carl, Pandian Richard, Andrews Robert, Harrison Elliot, Kimberley Andrew, Garnett Jane, Fosker Nigel, Hall Rebekah, Garner Patrick, Kelly Daniel, Bird Christine, Palmer Sophie, Gehring Ines, Berger Andrea, Dooley Christopher M, Ersan-\u00dcr\u00fcn Z\u00fcbeyde, Eser Cigdem, Geiger Horst, Geisler Maria, Karotki Lena, Kirn Anette, Konantz Judith, Konantz Martina, Oberl\u00e4nder Martina, Rudolph-Geiger Silke, Teucke Mathias, Lanz Christa, Raddatz G\u00fcnter, Osoegawa Kazutoyo, Zhu Baoli, Rapp Amanda, Widaa Sara, Langford Cordelia, Yang Fengtang, Schuster Stephan C, Carter Nigel P, Harrow Jennifer, Ning Zemin, Herrero Javier, Searle Steve M J, Enright Anton, Geisler Robert, Plasterk Ronald H A, Lee Charles, Westerfield Monte, de Jong Pieter J, Zon Leonard I, Postlethwait John H, N\u00fcsslein-Volhard Christiane, Hubbard Tim J P, Roest Crollius Hugues, Rogers Jane, Stemple Derek L", "evidence": [ { "database": "UniProtKB", "id": "A0AB32T3F9", "url": "https://www.uniprot.org/uniprotkb/A0AB32T3F9" } ], "reference": [ { "type": "PubMed", "id": "23594743", "url": "https://glygen.org/publication/PubMed/23594743" } ] }, { "title": "Istaroxime treatment ameliorates calcium dysregulation in a zebrafish model of phospholamban R14del cardiomyopathy.", "journal": "Nat. Commun.", "date": "2021", "authors": "Kamel SM, van Opbergen CJM, Koopman CD, Verkerk AO, Boukens BJD, de Jonge B, Onderwater YL, van Alebeek E, Chocron S, Polidoro Pontalti C, Weuring WJ, Vos MA, de Boer TP, van Veen TAB, Bakkers J", "evidence": [ { "database": "UniProtKB", "id": "A0JMK0", "url": "https://www.uniprot.org/uniprotkb/A0JMK0" } ], "reference": [ { "type": "PubMed", "id": "34887420", "url": "https://glygen.org/publication/PubMed/34887420" } ] }, { "title": "Amino acid primed mTOR activity is essential for heart regeneration.", "journal": "IScience", "date": "2021", "authors": "Miklas Jason W, Levy Shiri, Hofsteen Peter, Mex Diego Ic, Clark Elisa, Muster Jeanot, Robitaille Aaron M, Sivaram Gargi, Abell Lauren, Goodson Jamie M, Pranoto Inez, Madan Anup, Chin Michael T, Tian Rong, Murry Charles E, Moon Randall T, Wang Yuliang, Ruohola-Baker Hannele", "evidence": [ { "database": "UniProtKB", "id": "A0JMK0", "url": "https://www.uniprot.org/uniprotkb/A0JMK0" } ], "reference": [ { "type": "PubMed", "id": "34988408", "url": "https://glygen.org/publication/PubMed/34988408" } ] }, { "title": "Lifelong single-cell profiling of cranial neural crest diversification in zebrafish.", "journal": "Nat. Commun.", "date": "2022", "authors": "Fabian Peter, Tseng Kuo-Chang, Thiruppathy Mathi, Arata Claire, Chen Hung-Jhen, Smeeton Joanna, Nelson Nellie, Crump J Gage", "evidence": [ { "database": "UniProtKB", "id": "A0JMK0", "url": "https://www.uniprot.org/uniprotkb/A0JMK0" } ], "reference": [ { "type": "PubMed", "id": "35013168", "url": "https://glygen.org/publication/PubMed/35013168" } ] }, { "title": "Heterogeneous pdgfrb+ cells regulate coronary vessel development and revascularization during heart regeneration.", "journal": "Development", "date": "2022", "authors": "Kapuria Subir, Bai Haipeng, Fierros Juancarlos, Huang Ying, Ma Feiyang, Yoshida Tyler, Aguayo Antonio, Kok Fatma, Wiens Katie M, Yip Joycelyn K, McCain Megan L, Pellegrini Matteo, Nagashima Mikiko, Hitchcock Peter F, Mochizuki Naoki, Lawson Nathan D, Harrison Michael M R, Lien Ching-Ling", "evidence": [ { "database": "UniProtKB", "id": "A0JMK0", "url": "https://www.uniprot.org/uniprotkb/A0JMK0" } ], "reference": [ { "type": "PubMed", "id": "35088848", "url": "https://glygen.org/publication/PubMed/35088848" } ] }, { "title": "Beneficial impacts of neuromuscular electrical stimulation on muscle structure and function in the zebrafish model of Duchenne muscular dystrophy.", "journal": "Elife", "date": "2022", "authors": "Kilroy Elisabeth A, Ignacz Amanda C, Brann Kaylee L, Schaffer Claire E, Varney Devon, Alrowaished Sarah S, Silknitter Kodey J, Miner Jordan N, Almaghasilah Ahmed, Spellen Tashawna L, Lewis Alexandra D, Tilbury Karissa, King Benjamin L, Kelley Joshua B, Henry Clarissa A", "evidence": [ { "database": "UniProtKB", "id": "A0JMK0", "url": "https://www.uniprot.org/uniprotkb/A0JMK0" } ], "reference": [ { "type": "PubMed", "id": "35324428", "url": "https://glygen.org/publication/PubMed/35324428" } ] } ], "pathway": [ { "id": "dre:337176", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?dre:337176", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K692-1", "protein_name": "Periostin", "gene_name": "Postn", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVPLLPLSALLLLFLCDVDPANANSYYDKVLAHSRIRGRDQGPNVCALQQILGTKKKYFSSCKNWYQGAICGKKTTVLYECCPGYMRMEGMKGCPAVMPIDHVYGTLGIVGATTTQHYSDVSKLREEIEGKGSYTYFAPSNEAWDNLDSDIRRGLENNVNVELLNALHSHMVNKRMLTKDLKHGMVIPSMYNNLGLFINHYPNGVVTVNCARVIHGNQIATNGVVHVIDRVLTQIGTSIQDFIEAEDELSSFRAAAITSDLLESLGRDGHFTLFAPTNEAFEKLPRGVLERIMGDKVASEALMKYHILNTLQCSEAITGGAVFETMEGNTIEIGCEGDSISINGIKMVNKKDIVTKNGVIHLIDEVLIPDSAKQVIELAGKQQTTFTDLVAQLGLASSLKPDGEYTLLAPVNNAFSDDTLSMDQRLLKLILQNHILKVKVGLSDLYNGQILETIGGKQLRVFVYRTAICIENSCMVRGSKQGRNGAIHIFREIIQPAEKSLHEKLRQDKRFSIFLSLLEAADLKDLLTQPGDWTLFAPTNDAFKGMTNEEREILIGDKNALQNIILYHLTPGVYIGKGFEPGVTNILKTTQGSKIYVKGVNETLLVNELKSKESDIMTTNGVIHVVDKLLYPADIPVGNDQLLELLNKLIKYIQIKFVRGSTFKEIPMTVYRPAMTKIHIEGEPDFRLIKEGETVTEVIHGEPVIKKYTKIIDGVPVEITEKETREERIITGPEIKYTRISTGGGETEETLQKFLQKEVSKVTKFIEGGDGHLFEDEAIKRLLQGDTPAKKIQANKRVQGSRRRSREGRSQ", "length": 811 }, "evidence": [ { "id": "MGI:1926321", "url": "https://alliancegenome.org/gene/MGI:1926321#orthology", "database": "AGR" }, { "id": "HGNC:16953", "url": "https://alliancegenome.org/gene/HGNC:16953#orthology", "database": "AGR" }, { "id": "A0A0R4IS83", "url": "https://omabrowser.org/oma/group/A0A0R4IS83/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A3Q1N549-1", "protein_name": "Periostin", "gene_name": "POSTN", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MIPFLPVCSLFLLLVVNPANANGHYDKILAHSRIRGRDQGPNVCALQQILGTKKKYLSTCRNWYQGAICGKKTTVLYECCPGYMRMEGMKGCPAVMPIDHVYGTLGIVGATTTQSYSDVSKLREEIEGKGSFTYFAPSNEAWDNLDSDIRRGLESNVNVELLNALHSHMVNKRMLTKDLKNGMIIPSMYNNLGLFINHYPNGVVTVNCARIIHGNQIATNGVVHVIDRVLTQIGTSIQDFIEAEDELSSFRAAAITSDILETLGRDGHFTLFAPTNEAFEKLPRGVLERIMGDKVASEALMKYHILNTLQCSEAIMGGAVFETLEGNTIEIGCDGDSITVNGIKMVNKKDIVTNNGVIHLIDQVLVPDSAKQVIELAGNQQTTFTDLVAQLGLASALRPDGEYTLLAPVNNAFSDDTLSMDQRLLKLILQNHILKVKIGLNELYNGQKLETIGGKQLRVFVYRTAVCIENSCMVRGSKQGRNGAIHIFQEIIKPAEKSLHEKLKQDKRFSIFLSLLEAADLKELLTQPGDWTLFVPTNDAFKGMTNEEKEILIRDKNALQNIILYHLTPGVFIGKGFEPGVTNILKTTQGSKIYLKGVNDTLLVNELKSKESDIMTTNGVIHVVDKLLYPADTPVGNDQLLEILNKLIKYIQIKFVRGSTFKEIPITVYTTKIITKVVEPKIKVIEGSLQPIIKTEGRTIPKVKIEGEPEFRLIKEGETVTEVIHGEPIIKKYTKIIDGVPVEITEKETREERIITGPEIKYTRISTTGGETEETLKKLLQEEVTKVTKFIEGGDGHLFEDEEIKRLRKRIQNLHKLSMVITQRSLTKLISNSFC", "length": 835 }, "evidence": [ { "id": "A0A0R4IS83", "url": "https://omabrowser.org/oma/group/A0A0R4IS83/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "A0A3Q2U321-1", "protein_name": "Periostin", "gene_name": "POSTN", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKIFLLFTFSTFFLSAFEQAAASAHYDKILTHSRIRARDQGPNVCALQQVMGTKKKYFSTCRNWYQGSICGKKATVLYECCPGYMKMDGMRGCPAVAPIDHVYGTLGIVGATSTQQYSDMSKLREEIEGRGSFTFFAPSNEAWEQLSSEIHRNLIDNVNIELYNALHHHMVNKRMLTKDLKNGMTLVSMYNGQKLLINHYPNGVVTVNCARIIHGNQIATNGVVHVIDRVLTAVGNTIQDFIEVEDDLSSLRAAAITSDVLDTLGRPGYYTLFAPTNEAFERLPRGILERIMGDKVASEALVKFHILNTLQCSEAIMGGAVYETLEGNTLEVGCDGETLTVNGVKMVKRKDIVTSNGVIHLIDRVLIPDSAKQVIELGGAQQTTFTDLVTQLGLASSLRPEGQYTLLVPQNRAFSDDTLQMDQRLLKTILQNHIIKVKIGLNELYNGQELETIGGKLLRVFVYRTAVCVENSCMVRGSKEGRNGFIHVFRQIIKPAEKSLHEMLRNDKRFSVFLSLVKAADLDDVLSRPGAWTLFVPTNDAFKGLTDDDKAVLIRDKNALRNILLYHLTQGVFIGSGFEPGVTNILKTIQGGKLYLKTVNDTLLVNDLKSREPDLMATNGVIHVIDKLLYPADLPVGNDQLLTILKKLIKYIQIKFVRDSTFKEIPLTFYKINIIESNVQPIIRKEDPSITQLTKIIEGEPEFKIVREGETITKVIHGEPIIKTYTKIIDGRPVEVTEKKVTEERIIQGPEIKYTRITAGGTDNEENLKRLLEEEVTKVTKFIEGDAHLLEDEEIKRLLQGAGTEYTKVTKVIEGEPQIIEREIKKVHLEEAPVRKVQANKRTQGGSARRRTRLAYS", "length": 857 }, "evidence": [ { "id": "A0A0R4IS83", "url": "https://omabrowser.org/oma/group/A0A0R4IS83/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A0A8M1RKG7-1", "protein_name": "Periostin", "gene_name": "postna", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MILLFTATFTILVLSSLDQVDSSAYDKIVSHSRIRAKNEGPNVCALQQVMGTKKKYFSTCRNWYKKSICGKKAIVLYECCPGYMKLEGKRGCPAVAPIDSVYGTLDLVKAKTTQQYADQSKLREEIAGEGSYTIFAPSDDAWEELDPASKAAVISLGNTELYNALHYHMVSKRFLTKDLKNDMTLESMFNKQGLHINHYSNGVVTVNCARIIHGNQVATNGVVHVIDRVISVVSQTIKDVIETNDDLSSLSGVVVSADLQDQLGEPGHYTLFAPTNEAFDKINADALERLMSDQTVIQALLKYHLLNSVQCSEAIMAGSIYGTLEGSNIEIGCDGESLTVNGIKMVLKKDIVTSNGVIHLIDQVLMPDSAKQVMELVGKSQSVFSDMVSELGLSAALQPETEYTVLAPLNGAFSDEVMSMDQRLLKIILENHIVKLKVSLRDLYNGQLLETLGGKMLRVFIYRTAVCIENACMVRGSREGSNGALHLMSSLIQMPETTIYELLLKDGRFKIFLSLMESAGLTDLLKQDGSYTLFAPIDAAFGSLTKDDLALLKSDINVLRTILLYHFSNGIFINGGLEGGVTNLLKTIQGNNLQVLSVNSSIHVNSVDVPDFDLMASNGVVHVVKTLLYPQDLPVGREDILILLKRLIKYMQLKFVSGYTYRDIPLTFIKRTITTHVIERGPGTTVERTVIGEPIKVTRVIEGQPGVTKVTRVIEGDPSVTKVTRVVEGQPGITKVTRVIEGDPSFTKVTRVVGDQSLTKVTRVVEGDPRFTKVTRVVEDDPSLTKVTRVVEGEPSFTKVTRVVEGDPSFTKVTRVVGDPSLSKVTRVVEGKPSVTKVTRLIESHSASSDGEIDAGGEIKGIVGDDISNVQRFQNGEVHILQEEDIKQITDAIAQGGGPGITTITRVLKPEPRVVESEPGITTFTRVIKKKPQIVDGAPLETTFTRVIKPEPQIIEGPDFSKIVSLKDNPELFESETERITRIIKDGRSRKRAAIRQLQGSRRRARLVRHPTKPTQ", "length": 1016 }, "evidence": [ { "id": "MGI:1926321", "url": "https://alliancegenome.org/gene/MGI:1926321#orthology", "database": "AGR" }, { "id": "HGNC:16953", "url": "https://alliancegenome.org/gene/HGNC:16953#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q07895-1", "protein_name": "FAS1 domain-containing protein YLR001C", "gene_name": "", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MNMAIQTIKYIFWLLPILGLTQALLQNPGDDFPFSTVIDILSENVEFSTFLRIIQKTGHVQYLNELQNFTLFAPINSAFIKGDQTTDQFEEHFHIEDFLIHDRVLQVRDLENGTYLEKRAAKAPLLLRKHERHCFVNEIAVVEPDLLPSFQNASLQGINNLLLIQPQINELLVQLDEETQDLKIFSDFISSFSNYNAYTNSSTVLVPLDVNFRKFFNTIEINYLLDKYNKLGKSNTISQAKWAADRTSLLQELIIDDVYGGILPKELILENKNNRKLFMKSNSEGTSVSVNNSDYSPISNRIFEIGVVHGFSDLDFLRTHIQFDAEKYLHGLNCSEFVKELYFRDLEKFIQNGRKITIFVPQASFNEDRGYTKPSLLYHFVEGKIDLEQDFSSLRPIQYAPTQIYDSAFCSSAKRLGGHCQKFKITRSNKGYYINGRFKILNTKPYEIGNTSIYSIDDDLQLPGDLVLSLAPENHCSISLMLLKELNLLDLPSNHKGYTILLPCMNSWDNNDLTIDYLRSNKTALNLLMRNLIFEDLIYSNNYSISTTVKNLYGNSVSIGVQKIVGSQNLTKISVSTIKESIIIEESSDIFFNQGVIHPIDQLDFPVDLEISLKELIETTGTKEIFDFFNLFYDLSSIIWNNEEYSLLVPTASSIPLSGITANSTNLRKFLELHLIPANVTQNLLDCNGSISTKLGTKLNCRKDHLDNVFVSIQGDWTKEVRVLKTGCTTNLKSSCIFLIDKPISLSWLNSEKYHLRLPGIAVGFGVIIGVTIAISLLFCIIITRGGKVKDKNQRGRNDRATTPLIQHSPIIHNPSYSATAHLSPLSQPTFEGSYSVNAIQTPRDIRRVGSDQKGGRSVSTS", "length": 862 }, "evidence": [ { "id": "MGI:1926321", "url": "https://alliancegenome.org/gene/MGI:1926321#orthology", "database": "AGR" }, { "id": "HGNC:16953", "url": "https://alliancegenome.org/gene/HGNC:16953#orthology", "database": "AGR" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q15063-1", "protein_name": "Periostin", "gene_name": "POSTN", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MIPFLPMFSLLLLLIVNPINANNHYDKILAHSRIRGRDQGPNVCALQQILGTKKKYFSTCKNWYKKSICGQKTTVLYECCPGYMRMEGMKGCPAVLPIDHVYGTLGIVGATTTQRYSDASKLREEIEGKGSFTYFAPSNEAWDNLDSDIRRGLESNVNVELLNALHSHMINKRMLTKDLKNGMIIPSMYNNLGLFINHYPNGVVTVNCARIIHGNQIATNGVVHVIDRVLTQIGTSIQDFIEAEDDLSSFRAAAITSDILEALGRDGHFTLFAPTNEAFEKLPRGVLERIMGDKVASEALMKYHILNTLQCSESIMGGAVFETLEGNTIEIGCDGDSITVNGIKMVNKKDIVTNNGVIHLIDQVLIPDSAKQVIELAGKQQTTFTDLVAQLGLASALRPDGEYTLLAPVNNAFSDDTLSMDQRLLKLILQNHILKVKVGLNELYNGQILETIGGKQLRVFVYRTAVCIENSCMEKGSKQGRNGAIHIFREIIKPAEKSLHEKLKQDKRFSTFLSLLEAADLKELLTQPGDWTLFVPTNDAFKGMTSEEKEILIRDKNALQNIILYHLTPGVFIGKGFEPGVTNILKTTQGSKIFLKEVNDTLLVNELKSKESDIMTTNGVIHVVDKLLYPADTPVGNDQLLEILNKLIKYIQIKFVRGSTFKEIPVTVYTTKIITKVVEPKIKVIEGSLQPIIKTEGPTLTKVKIEGEPEFRLIKEGETITEVIHGEPIIKKYTKIIDGVPVEITEKETREERIITGPEIKYTRISTGGGETEETLKKLLQEEVTKVTKFIEGGDGHLFEDEEIKRLLQGDTPVRKLQANKKVQGSRRRLREGRSQ", "length": 836 }, "evidence": [ { "id": "MGI:1926321", "url": "https://alliancegenome.org/gene/MGI:1926321#orthology", "database": "AGR" }, { "id": "HGNC:16953", "url": "https://alliancegenome.org/gene/HGNC:16953#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-030131-9120", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-030131-9120#orthology", "database": "AGR" }, { "id": "A0A0R4IS83", "url": "https://omabrowser.org/oma/group/A0A0R4IS83/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q62009-1", "protein_name": "Periostin", "gene_name": "Postn", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVPLLPLYALLLLFLCDINPANANSYYDKVLAHSRIRGRDQGPNVCALQQILGTKKKYFSSCKNWYQGAICGKKTTVLYECCPGYMRMEGMKGCPAVMPIDHVYGTLGIVGATTTQHYSDVSKLREEIEGKGSYTYFAPSNEAWENLDSDIRRGLENNVNVELLNALHSHMVNKRMLTKDLKHGMVIPSMYNNLGLFINHYPNGVVTVNCARVIHGNQIATNGVVHVIDRVLTQIGTSIQDFLEAEDDLSSFRAAAITSDLLESLGRDGHFTLFAPTNEAFEKLPRGVLERIMGDKVASEALMKYHILNTLQCSEAITGGAVFETMEGNTIEIGCEGDSISINGIKMVNKKDIVTKNGVIHLIDEVLIPDSAKQVIELAGKQQTTFTDLVAQLGLASSLKPDGEYTLLAPVNNAFSDDTLSMDQRLLKLILQNHILKVKVGLSDLYNGQILETIGGKQLRVFVYRTAICIENSCMVRGSKQGRNGAIHIFREIIQPAEKSLHDKLRQDKRFSIFLSLLEAADLKDLLTQPGDWTLFAPTNDAFKGMTSEERELLIGDKNALQNIILYHLTPGVYIGKGFEPGVTNILKTTQGSKIYLKGVNETLLVNELKSKESDIMTTNGVIHVVDKLLYPADIPVGNDQLLELLNKLIKYIQIKFVRGSTFKEIPMTVYTTKIITKVVEPKIKVIQGSLQPIIKTEGPAMTKIQIEGDPDFRLIKEGETVTEVIHGEPVIKKYTKIIDGVPVEITEKQTREERIITGPEIKYTRISTGGGETGETLQKFLQKEVSKVTKFIEGGDGHLFEDEEIKRLLQGDTPAKKIPANKRVQGPRRRSREGRSQ", "length": 838 }, "evidence": [ { "id": "MGI:1926321", "url": "https://alliancegenome.org/gene/MGI:1926321#orthology", "database": "AGR" }, { "id": "HGNC:16953", "url": "https://alliancegenome.org/gene/HGNC:16953#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-030131-9120", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-030131-9120#orthology", "database": "AGR" }, { "id": "A0A0R4IS83", "url": "https://omabrowser.org/oma/group/A0A0R4IS83/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q86B94-1", "protein_name": "FI19380p1", "gene_name": "mfas", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MLRLWACLLLLGSIQIQAVPFYGDSSSEEVAEFDDSSDSTHESSDNSSFMPHLTHPLPAHRNLFAPLPFAPLAPLEPQDPLHAQASQRMASVWNGPAPLAPQLHSSHLLPLFSSGYDTEFVPLEHQQQPQGRQETAATVPAQTPSGVEQKPFNVDTITTDVNSPNPAIFFQQSFPFFGNEFFNSFGGFGFGAAQEPWWKGPNVCTEKEEDETVASETEAEETVDTFGQERDGVTNVVRSPLFGQFQFSVNSCAEKPNKHVCTKIVNQNGKKKTLTLTRQCCYGYGRPRNADFTTPCEKIDIKDVEATASDMGAKQFLESARTAGELADMLGAGSGKKVTLFVPNDAAFMEYRGHHQQENNVEDAKAEASKPSIYKLHAVLGEVQLEDVPNEKLLQTELPDQKIRINSYQLPAALGLEPYRFAANCVPIEKHDKLSEQALVHTLGGVLKPLTKNLMDIIRERADMSIMRTVLEKTNLSAMLEDDKPVTIFVPTDAAFDKLEPHLRRALKEGRGCASNILKNHLLDLTFCSLATVPGAKTTAYNLLGEPLLLNRTHRAANQTGPTPIYINNLAKIIDADIMGTNGVLHVIDTILPTESALPMTSLMSQKNLTIFQRLLEASGYDDQFDDLDNVTIFAPTDKALQNTEWARMLKEQPELLNHNLDLLEFLNYHVVKPMIKTCDLSEKSLPTVAGSSVRLNLYSTHALFSDVMNRATVNCARLVHFDDESCGSVLHQVDRALAPPKNNMLKLLEANPNYSKFLELVRKANLTQLLSNDSRSLTLLVPKNDIFEELNESGEGSKPADPMALVKTHIVEDVVCCAGIIPTNWPFVRSIESISGQHLRITRDRRPKIENAGVTKCDVVATNGILHEINDIIVPRPQRQQQQRPQLIPPGAGYQPQGDFDVFF", "length": 905 }, "evidence": [ { "id": "MGI:1926321", "url": "https://alliancegenome.org/gene/MGI:1926321#orthology", "database": "AGR" }, { "id": "HGNC:16953", "url": "https://alliancegenome.org/gene/HGNC:16953#orthology", "database": "AGR" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IS83", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IS83" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IS83", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IS83" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IS83", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IS83" } ], "pmid": "" }, { "name": "extracellular matrix organization", "id": "GO:0030198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030198", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IS83", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IS83" } ], "pmid": "" }, { "name": "muscle attachment", "id": "GO:0016203", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016203", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IS83", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IS83" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cell adhesion molecule binding", "id": "GO:0050839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050839", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IS83", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IS83" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 599, "end_pos": 601, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.agr", "label": "AGR Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 599, "end_pos": 601 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, 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