{ "uniprot_canonical_ac": "A0A0R4IPR8-1", "uniprot_ac": "A0A0R4IPR8", "uniprot_id": "A0A0R4IPR8_DANRE", "mass": { "chemical_mass": 83501.0, "monoisotopic_mass": 83501.0 }, "refseq": { "ac": "XP_697386", "name": "ARF GTPase-activating protein GIT1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_697386" }, "gene_names": [ { "name": "git1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IPR8", "id": "A0A0R4IPR8" }, { "name": "git1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_697386", "id": "XP_697386" } ], "protein_names": [ { "name": "ARF GTPase-activating protein GIT1 isoform X1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_697386", "id": "XP_697386" }, { "name": "ARF GTPase-activating protein GIT1 isoform X1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IPR8/entry#names_and_taxonomy", "id": "A0A0R4IPR8" }, { "name": "G protein-coupled receptor kinase-interacting ArfGAP 1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IPR8/entry#names_and_taxonomy", "id": "A0A0R4IPR8" } ], "function": [ { "annotation": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 30, 2010 this sequence version replaced XP_697386.3. COMPLETENESS: full length.", "evidence": [ { "database": "RefSeq", "id": "XP_697386", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_697386" } ] } ], "disease": [ { "disease_id": "DOID:1094", "recommended_name": { "id": "DOID:1094", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1094", "name": "attention deficit hyperactivity disorder", "description": "A specific developmental disorder that is characterized by co-existence of attentional problems and hyperactivity, with each behavior occurring infrequently alone and symptoms starting before seven years of age." }, "synonyms": [ { "id": "DOID:1094", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1094", "name": "ADHD", "description": "" }, { "id": "DOID:1094", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1094", "name": "attention deficit disorder", "description": "" }, { "id": "DOID:1094", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1094", "name": "hyperkinetic disorder", "description": "" }, { "id": "MONDO:0012151", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012151", "name": "attention deficit-hyperactivity disorder, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012151", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012151", "name": "ADHD3", "description": "" }, { "id": "MONDO:0012151", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012151", "name": "attention Deficit-hyperactivity disorder, susceptibility to, type 3", "description": "" }, { "id": "MONDO:0012151", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012151", "name": "attention deficit-hyperactivity disorder, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012150", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012150", "name": "attention deficit-hyperactivity disorder, susceptibility to, 2", "description": "" }, { "id": "MONDO:0012150", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012150", "name": "ADHD2", "description": "" }, { "id": "MONDO:0012150", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012150", "name": "attention Deficit-hyperactivity disorder, susceptibility to, type 2", "description": "" }, { "id": "MONDO:0012150", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012150", "name": "attention deficit-hyperactivity disorder, susceptibility to, 2", "description": "" }, { "id": "MONDO:0012149", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012149", "name": "attention deficit-hyperactivity disorder, susceptibility to, 1", "description": "" }, { "id": "MONDO:0012149", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012149", "name": "ADHD1", "description": "" }, { "id": "MONDO:0012149", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012149", "name": "attention deficit-hyperactivity disorder, susceptibility to, 1", "description": "" }, { "id": "MONDO:0012149", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012149", "name": "attention deficit-hyperactivity disorder, susceptibility to, type 1", "description": "" }, { "id": "MONDO:0012152", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012152", "name": "attention deficit-hyperactivity disorder, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012152", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012152", "name": "ADHD4", "description": "" }, { "id": "MONDO:0012152", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012152", "name": "attention Deficit-hyperactivity disorder, susceptibility to, type 4", "description": "" }, { "id": "MONDO:0012152", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012152", "name": "attention deficit-hyperactivity disorder, susceptibility to, 4", "description": "" }, { "id": "MONDO:0100518", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100518", "name": "hereditary attention deficit-hyperactivity disorder", "description": "An instance of attention deficit-hyperactivity disorder that is caused by an inherited genomic modification in an individual." }, { "id": "MONDO:0012863", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012863", "name": "attention deficit-hyperactivity disorder, susceptibility to, 6", "description": "" }, { "id": "MONDO:0012863", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012863", "name": "ADHD6", "description": "" }, { "id": "MONDO:0012863", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012863", "name": "attention Deficit-hyperactivity disorder, susceptibility to, type 6", "description": "" }, { "id": "MONDO:0012863", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012863", "name": "attention deficit-hyperactivity disorder, susceptibility to, 6", "description": "" }, { "id": "MONDO:0012863", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012863", "name": "digit span quantitative trait locus", "description": "" }, { "id": "MONDO:0012862", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012862", "name": "attention deficit-hyperactivity disorder, susceptibility to, 5", "description": "" }, { "id": "MONDO:0012862", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012862", "name": "ADHD5", "description": "" }, { "id": "MONDO:0012862", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012862", "name": "attention Deficit-hyperactivity disorder, susceptibility to, type 5", "description": "" }, { "id": "MONDO:0012862", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012862", "name": "attention deficit-hyperactivity disorder, susceptibility to, 5", "description": "" }, { "id": "MONDO:0012862", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012862", "name": "motor timing quantitative trait locus", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "1094", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1094" } ] }, { "disease_id": "DOID:12858", "recommended_name": { "id": "DOID:12858", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12858", "name": "Huntington's disease", "description": "A neurodegenerative disease that has_material_basis_in autosomal dominant inheritance and is characterized by unwanted choreatic movements, behavioral and psychiatric disturbances and dementia and has_material_basis_in expansion of CAG triplet repeats (glutamine) resulting in neuron degeneration affecting muscle coordination, cognitive abilities." }, "synonyms": [ { "id": "DOID:12858", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12858", "name": "HD", "description": "" }, { "id": "DOID:12858", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12858", "name": "Huntington disease", "description": "" }, { "id": "DOID:12858", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12858", "name": "Huntington's chorea", "description": "" }, { "id": "MONDO:0007739", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007739", "name": "Huntington disease", "description": "Huntington disease (HD) is a rare neurodegenerative disorder of the central nervous system characterized by unwanted choreatic movements, behavioral and psychiatric disturbances and dementia." }, { "id": "MONDO:0007739", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007739", "name": "HD", "description": "" }, { "id": "MONDO:0007739", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007739", "name": "Huntington chorea", "description": "" }, { "id": "MONDO:0007739", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007739", "name": "Huntington disease", "description": "" }, { "id": "MONDO:0007739", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007739", "name": "Huntington's Disease", "description": "" }, { "id": "MONDO:0007739", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007739", "name": "Huntington's chorea", "description": "" }, { "id": "MONDO:0007739", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007739", "name": "Huntington's disease", "description": "" }, { "id": "MIM:143100", "resource": "MIM", "url": "https://www.omim.org/entry/143100", "name": "Huntington disease", "description": "Huntington disease" } ], "unlinked_id_list": [], "evidence": [ { "id": "12858", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:12858" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Danio rerio", "taxid": 7955, "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IPR8", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IPR8" } ], "common_name": "Zebrafish", "glygen_name": "Zebrafish", "reference_species": "Danio rerio [7955]" } ], "gene": [ { "name": "git1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IPR8", "locus": {} } ], "crossref": [ { "id": "ZFIN:ZDB-GENE-100408-5", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-100408-5", "database": "AGR", "categories": [ "Protein Classification" ] }, { "id": "ENSDARG00000039489", "url": "https://bgee.org/?page=gene&gene_id=ENSDARG00000039489", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "568935", "url": "https://www.ncbi.nlm.nih.gov/gene/568935", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001164", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001164", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013724", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013724", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022018", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022018", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032352", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032352", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037278", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037278", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038508", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038508", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047161", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047161", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dre:568935", "url": "https://www.genome.jp/dbget-bin/www_bget?dre:568935", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HLEYDEH", "url": "https://omabrowser.org/oma/group/HLEYDEH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A0R4IPR8", "url": "https://www.orthodb.org/?gene=A0A0R4IPR8", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A8M3AHJ1", "url": "https://www.orthodb.org/?gene=A0A8M3AHJ1", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "E7FAZ2", "url": "https://www.orthodb.org/?gene=E7FAZ2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46097", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46097", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46097:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46097:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01412", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01412", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF08518", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08518", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF12205", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12205", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF12796", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12796", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF16559", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16559", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "XP_697386", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_697386", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A0R4IPR8", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IPR8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0R4IPR8-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IPR8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8M3AHJ1", "url": "https://www.uniprot.org/uniprotkb/A0A8M3AHJ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8M3AHJ1-1", "url": "https://www.uniprot.org/uniprotkb/A0A8M3AHJ1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E7FAZ2", "url": "https://www.uniprot.org/uniprotkb/E7FAZ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E7FAZ2-1", "url": "https://www.uniprot.org/uniprotkb/E7FAZ2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "ZDB-GENE-100408-5", "url": "https://zfin.org/ZDB-GENE-100408-5", "database": "ZFIN", "categories": [ "Protein", "Organism-specific" ] } ], "sequence": { "sequence": "MSRKVQRSEVCADCSAPDPGWSSINRGVLICDECCSVHRSLGRHISIVKHLRHSGWPPSLLQMVQTLASNGANSIWEHSLLDPAQVQSGRRKPNPQDKVHPTKSEFIRAKYQMLAFVHKLPCRDDDGVTTKDLSKQLHSSVRTGSLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQVLQAELLVVYGADPGAPDINGRTPIDYARQAGHVELAERLVECQYELTDRLAFYLCGRRPDHKNGHYIIPQMADRARPKCPTQSLDLSELAKAAKKKLQALNNRLFEELAMDVYDEVDRRENDAVWLTTQNHSTLVTERSAVPFLPVNPEYSATRNQGRQKLARFNAREFATLIIDILSDAKRRQHGKGLTSPTDPLDLSQVDDDQHDYDSVASDEDTDSELTAQNNNNTQRNNRAKSMDSSDLSDGPITLQEYLEVKKALASSEAKVQQLMKVNNNLSEELRRLQKEISRMQTENSALRGAQAGSGATMTGGGVPGHWPDRVRGMGGGGGLSGDSSLIAPSSTPHRRDRQAFSMYEPVGTTSKVLSPALDPLTCRLQPLSPVRKGAPAGPTPYGGAHLSASTDGRYNHPKAGEKYGSGTDSDYDNSQTYDVSIGVGRSSEEDSRGDVDDTEGDPDPTLPCTEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLFPKRPALDAVRSSLKLLAASASRLQVECRKAAPSDSSASTVDYQLLTQQVIQCAYDIAKAAKQLVTITTREKKQ", "length": 761, "header": "tr|A0A0R4IPR8-1|A0A0R4IPR8_DANRE Isoform 1 of ARF GTPase-activating protein GIT1 isoform X1 OS=Danio rerio OX=7955 GN=git1 PE=1 SV=1 CANONICAL=A0A0R4IPR8-1" }, "isoforms": [ { "isoform_ac": "A0A0R4IPR8-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IPR8/entry#A0A0R4IPR8-1", "sequence": { "sequence": "MSRKVQRSEVCADCSAPDPGWSSINRGVLICDECCSVHRSLGRHISIVKHLRHSGWPPSLLQMVQTLASNGANSIWEHSLLDPAQVQSGRRKPNPQDKVHPTKSEFIRAKYQMLAFVHKLPCRDDDGVTTKDLSKQLHSSVRTGSLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQVLQAELLVVYGADPGAPDINGRTPIDYARQAGHVELAERLVECQYELTDRLAFYLCGRRPDHKNGHYIIPQMADRARPKCPTQSLDLSELAKAAKKKLQALNNRLFEELAMDVYDEVDRRENDAVWLTTQNHSTLVTERSAVPFLPVNPEYSATRNQGRQKLARFNAREFATLIIDILSDAKRRQHGKGLTSPTDPLDLSQVDDDQHDYDSVASDEDTDSELTAQNNNNTQRNNRAKSMDSSDLSDGPITLQEYLEVKKALASSEAKVQQLMKVNNNLSEELRRLQKEISRMQTENSALRGAQAGSGATMTGGGVPGHWPDRVRGMGGGGGLSGDSSLIAPSSTPHRRDRQAFSMYEPVGTTSKVLSPALDPLTCRLQPLSPVRKGAPAGPTPYGGAHLSASTDGRYNHPKAGEKYGSGTDSDYDNSQTYDVSIGVGRSSEEDSRGDVDDTEGDPDPTLPCTEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLFPKRPALDAVRSSLKLLAASASRLQVECRKAAPSDSSASTVDYQLLTQQVIQCAYDIAKAAKQLVTITTREKKQ", "length": 761, "header": "tr|A0A0R4IPR8-1|A0A0R4IPR8_DANRE Isoform 1 of ARF GTPase-activating protein GIT1 isoform X1 OS=Danio rerio OX=7955 GN=git1 PE=1 SV=1 CANONICAL=A0A0R4IPR8-1" }, "locus": {} }, { "isoform_ac": "A0A8M3AHJ1-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IPR8/entry#A0A8M3AHJ1-1", "sequence": { "sequence": "MSRKVQRSEVCADCSAPDPGWSSINRGVLICDECCSVHRSLGRHISIVKHLRHSGWPPSLLQMVQTLASNGANSIWEHSLLDPAQVQSGRRKPNPQDKVHPTKSEFIRAKYQMLAFVHKLPCRDDDGVTTKDLSKQLHSSVRTGSLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQVLQAELLVVYGADPGAPDINGRTPIDYARQAGHVELAERLVECQYELTDRLAFYLCGRRPDHKNGHYIIPQMADRARPKCPTQSLDLSELAKAAKKKLQALNNRLFEELAMDVYDEVDRRENDAVWLTTQNHSTLVTERSAVPFLPVNPEYSATRNQGRQKLARFNAREFATLIIDILSDAKRRQHGKGLTSPTDPLDLSQVDDDQHDYDSVASDEDTDSELTAQNNNNTQRNNRAKSMDSSDLSDGPITLQEYLEVKKALASSEAKVQQLMKVNNNLSEELRRLQKEVRKGAPAGPTPYGGAHLSASTDGRYNHPKAGEKYGSGTDSDYDNSQTYDVSIGVGRSSEEDSRGDVDDTEGDPDPTLPCTEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLFPKRPALDAVRSSLKLLAASASRLQVECRKAAPSDSSASTVDYQLLTQQVIQCAYDIAKAAKQLVTITTREKKQ", "length": 667, "header": "tr|A0A8M3AHJ1-1|A0A8M3AHJ1_DANRE Computationally mapped isoform of ARF GTPase-activating protein GIT1 isoform X3 OS=Danio rerio OX=7955 GN=git1 PE=1 SV=1 CANONICAL=A0A0R4IPR8-1" }, "locus": {} }, { "isoform_ac": "E7FAZ2-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IPR8/entry#E7FAZ2-1", "sequence": { "sequence": "MSRKVQRSEVCADCSAPDPGWSSINRGVLICDECCSVHRSLGRHISIVKHLRHSGWPPSLLQMVQTLASNGANSIWEHSLLDPAQVQSGRRKPNPQDKVHPTKSEFIRAKYQMLAFVHKLPCRDDDGVTTKDLSKQLHSSVRTGSLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQVLQAELLVVYGADPGAPDINGRTPIDYARQAGHVELAERLVECQYELTDRLAFYLCGRRPDHKNGHYIIPQMADSLDLSELAKAAKKKLQALNNRLFEELAMDVYDEVDRRENDAVWLTTQNHSTLVTERSAVPFLPVNPEYSATRNQGRQKLARFNAREFATLIIDILSDAKRRQHGKGLTSPTDPLDLSQVDDDQHDYDSVASDEDTDSELTAQNNNNTQRNNRAKSMDSSDLSDGPITLQEYLEVKKALASSEAKVQQLMKVNNNLSEELRRLQKEISRMQTENSALRGAQAGSGATMTGGGVPGHWPDRVRGMGGGGGLSGDSSLIAPSSTPHRRDRQAFSMYEPVGTTSKVLSPALDPLTCRLQPLSPVRKGAPAGPTPYGGAHLSASTDGRYNHPKAGEKYGSGTDSDYDNSQTYDVSIGVGRSSEEDSRGDVDDTEGDPDPTLPCTEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLFPKRPALDAVRSSLKLLAASASRLQVECRKAAPSDSSASTVDYQLLTQQVIQCAYDIAKAAKQLVTITTREKKQ", "length": 752, "header": "tr|E7FAZ2-1|A0A0R4IPR8_DANRE Computationally mapped isoform of ARF GTPase-activating protein GIT1 isoform X1 OS=Danio rerio OX=7955 GN=git1 PE=1 SV=1 CANONICAL=A0A0R4IPR8-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "start_pos": 571, "start_aa": "Thr", "end_pos": 571, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr571", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "00000000000000001000.00000000001000.0.xxxxx" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "The zebrafish reference genome sequence and its relationship to the human genome.", "journal": "Nature", "date": "2013", "authors": "Howe Kerstin, Clark Matthew D, Torroja Carlos F, Torrance James, Berthelot Camille, Muffato Matthieu, Collins John E, Humphray Sean, McLaren Karen, Matthews Lucy, McLaren Stuart, Sealy Ian, Caccamo Mario, Churcher Carol, Scott Carol, Barrett Jeffrey C, Koch Romke, Rauch Gerd-J\u00f6rg, White Simon, Chow William, Kilian Britt, Quintais Leonor T, Guerra-Assun\u00e7\u00e3o Jos\u00e9 A, Zhou Yi, Gu Yong, Yen Jennifer, Vogel Jan-Hinnerk, Eyre Tina, Redmond Seth, Banerjee Ruby, Chi Jianxiang, Fu Beiyuan, Langley Elizabeth, Maguire Sean F, Laird Gavin K, Lloyd David, Kenyon Emma, Donaldson Sarah, Sehra Harminder, Almeida-King Jeff, Loveland Jane, Trevanion Stephen, Jones Matt, Quail Mike, Willey Dave, Hunt Adrienne, Burton John, Sims Sarah, McLay Kirsten, Plumb Bob, Davis Joy, Clee Chris, Oliver Karen, Clark Richard, Riddle Clare, Elliot David, Eliott David, Threadgold Glen, Harden Glenn, Ware Darren, Begum Sharmin, Mortimore Beverley, Mortimer Beverly, Kerry Giselle, Heath Paul, Phillimore Benjamin, Tracey Alan, Corby Nicole, Dunn Matthew, Johnson Christopher, Wood Jonathan, Clark Susan, Pelan Sarah, Griffiths Guy, Smith Michelle, Glithero Rebecca, Howden Philip, Barker Nicholas, Lloyd Christine, Stevens Christopher, Harley Joanna, Holt Karen, Panagiotidis Georgios, Lovell Jamieson, Beasley Helen, Henderson Carl, Gordon Daria, Auger Katherine, Wright Deborah, Collins Joanna, Raisen Claire, Dyer Lauren, Leung Kenric, Robertson Lauren, Ambridge Kirsty, Leongamornlert Daniel, McGuire Sarah, Gilderthorp Ruth, Griffiths Coline, Manthravadi Deepa, Nichol Sarah, Barker Gary, Whitehead Siobhan, Kay Michael, Brown Jacqueline, Murnane Clare, Gray Emma, Humphries Matthew, Sycamore Neil, Barker Darren, Saunders David, Wallis Justene, Babbage Anne, Hammond Sian, Mashreghi-Mohammadi Maryam, Barr Lucy, Martin Sancha, Wray Paul, Ellington Andrew, Matthews Nicholas, Ellwood Matthew, Woodmansey Rebecca, Clark Graham, Cooper James D, Cooper James, Tromans Anthony, Grafham Darren, Skuce Carl, Pandian Richard, Andrews Robert, Harrison Elliot, Kimberley Andrew, Garnett Jane, Fosker Nigel, Hall Rebekah, Garner Patrick, Kelly Daniel, Bird Christine, Palmer Sophie, Gehring Ines, Berger Andrea, Dooley Christopher M, Ersan-\u00dcr\u00fcn Z\u00fcbeyde, Eser Cigdem, Geiger Horst, Geisler Maria, Karotki Lena, Kirn Anette, Konantz Judith, Konantz Martina, Oberl\u00e4nder Martina, Rudolph-Geiger Silke, Teucke Mathias, Lanz Christa, Raddatz G\u00fcnter, Osoegawa Kazutoyo, Zhu Baoli, Rapp Amanda, Widaa Sara, Langford Cordelia, Yang Fengtang, Schuster Stephan C, Carter Nigel P, Harrow Jennifer, Ning Zemin, Herrero Javier, Searle Steve M J, Enright Anton, Geisler Robert, Plasterk Ronald H A, Lee Charles, Westerfield Monte, de Jong Pieter J, Zon Leonard I, Postlethwait John H, N\u00fcsslein-Volhard Christiane, Hubbard Tim J P, Roest Crollius Hugues, Rogers Jane, Stemple Derek L", "evidence": [ { "database": "UniProtKB", "id": "E7FAZ2", "url": "https://www.uniprot.org/uniprotkb/E7FAZ2" } ], "reference": [ { "type": "PubMed", "id": "23594743", "url": "https://glygen.org/publication/PubMed/23594743" } ] } ], "pathway": [ { "id": "dre:568935", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?dre:568935", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q68FF6-1", "protein_name": "ARF GTPase-activating protein GIT1", "gene_name": "Git1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSRKGPRAEVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQTLQAELLVVYGADPGSPDVNGRTPIDYARQAGHHELAERLVECQYELTDRLAFYLCGRKPDHKNGHYIIPQMADRSRQKCMSQSLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRENDAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGRQKLARFNAREFATLIIDILSEAKRRQQGKSLSSPTDNLELSARSQSELDDQHDYDSVASDEDTDQEPLPSAGATRNNRARSMDSSDLSDGAVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENLQLRQPPGPVPPPSLPSERAEHTLMGPGGSTHRRDRQAFSMYEPGSALKPFGGTPGDELATRLQPFHSTELEDDAIYSVHVPAGLYRIRKGVSASSVPFTPSSPLLSCSQEGSRHASKLSRHGSGADSDYENTQSGDPLLGLEGKRFLELSKEDELHPELESLDGDLDPGLPSTEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLFPKRPALEPVRSSLRLLNASAYRLQSECRKTVPPEPGAPVDFQLLTQQVIQCAYDIAKAAKQLVTITTREKKQ", "length": 770 }, "evidence": [ { "id": "MGI:1927140", "url": "https://alliancegenome.org/gene/MGI:1927140#orthology", "database": "AGR" }, { "id": "HGNC:4272", "url": "https://alliancegenome.org/gene/HGNC:4272#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-100408-5", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-100408-5#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q95RG8-1", "protein_name": "ARF GTPase-activating protein Git", "gene_name": "Git", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MCFASSIIEAHRKLFIAPPDLDHSDPATPTISTRSKMPRGKSRLQTEVCGDCGAGDPSWASINRGILLCADCCSVHRSLGRHISIVKSLRQGNWEPSVLNFVNSLNAHGANSVWEHHLLDGSTNSTGGKHVPRWRKPTPKDALHPTKSDFIKAKHVNLTFVLKPSLQDDDDGNGSAGCLEQELSRQLHASVRTSNLETSLRFLVQGADPNYYHEDKLSTPLHMAAKFGQASQIEMLLIYGADVNALDGNGMTPLELARANNHNTIAERLLDAMYDVTDRIITFLGGKKPDHASGRHMIIPDANGADISEQLKIARGKLQLVPNKMFEELVMDLYDEVDRRECEAIWSTSTLNADHATVPFLPANPFLSATRNQGRQKLARFNRAEFTGLLTDVLVDAMRRQNMANLRPMDAPVAGHQSLQSLPYANNSMLLGSFEQGGHDPNLSDDEPIYDPVASDDDYAPVPPMAQQAIVHTPPRSANSHNEMETLRKQLNDYKSEINQLKNVVQMLSSENTQLKSKFSSASNNSVYDEPLRIDLSLSSPDTEHEPLSLPEGGTANGESGSSNDSSNQSTIKRPASMYERRLVPNVAKGNTDIRNTTSMYQMAGDGKPFGEEVKVRSDLVTRRLKELIRAMQPVPEDQKQSIAPHGELIRSAVTDLIALYANLPPNASDPSRETLKLLTRQNILIQHECENLQKAIEADDKQAIQKNTLEVRDCAFHIASAIKTLVLQFY", "length": 731 }, "evidence": [ { "id": "MGI:1927140", "url": "https://alliancegenome.org/gene/MGI:1927140#orthology", "database": "AGR" }, { "id": "HGNC:4272", "url": "https://alliancegenome.org/gene/HGNC:4272#orthology", "database": "AGR" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9Y2X7-1", "protein_name": "ARF GTPase-activating protein GIT1", "gene_name": "GIT1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSRKGPRAEVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQTLQAELLVVYGADPGSPDVNGRTPIDYARQAGHHELAERLVECQYELTDRLAFYLCGRKPDHKNGHYIIPQMADSLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRENDAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGRQKLARFNAREFATLIIDILSEAKRRQQGKSLSSPTDNLELSLRSQSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRARSMDSSDLSDGAVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENLQLRQPPGPVPTPPLPSERAEHTPMAPGGSTHRRDRQAFSMYEPGSALKPFGGPPGDELTTRLQPFHSTELEDDAIYSVHVPAGLYRIRKGVSASAVPFTPSSPLLSCSQEGSRHTSKLSRHGSGADSDYENTQSGDPLLGLEGKRFLELGKEEDFHPELESLDGDLDPGLPSTEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLFPKRPALEPVRSSLRLLNASAYRLQSECRKTVPPEPGAPVDFQLLTQQVIQCAYDIAKAAKQLVTITTREKKQ", "length": 761 }, "evidence": [ { "id": "MGI:1927140", "url": "https://alliancegenome.org/gene/MGI:1927140#orthology", "database": "AGR" }, { "id": "HGNC:4272", "url": "https://alliancegenome.org/gene/HGNC:4272#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-100408-5", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-100408-5#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9Z272-1", "protein_name": "ARF GTPase-activating protein GIT1", "gene_name": "Git1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSRKGPRAEVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQTLQAELLVVYGADPGSPDVNGRTPIDYARQAGHHELAERLVECQYELTDRLAFYLCGRKPDHKNGHYIIPQMADRSRQKCMSQSLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRENDAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGRQKLARFNAREFATLIIDILSEAKRRQQGKSLSSPTDNLELSARNQSDLDDQHDYDSVASDEDTDQEPLPSAGATRNNRARSMDSSDLSDGAVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRKLQREIHKLQAENLQLRQPPGPVPVPSLPSERAEHTLMGPGGSTHRRDRQAFSMYEPGSALKPFGGAPGDELATRLQPFHSTELEDDAIYSVHVPAGLYRIRKGVSASSVTFTPSSPLLSSSQEGSRHASKLSRHGSGAESDYENTQSGEPLLGLEGKRFLELSKEDELHAELESLDGDPDPGLPSTEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLFPKRPALEPVRSSLRLLNASAYRLQSECRKTVPPEPGAPVDFQLLTQQVIQCAYDIAKAAKQLVTITTREKKQ", "length": 770 }, "evidence": [ { "id": "MGI:1927140", "url": "https://alliancegenome.org/gene/MGI:1927140#orthology", "database": "AGR" }, { "id": "HGNC:4272", "url": "https://alliancegenome.org/gene/HGNC:4272#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "angiogenesis", "id": "GO:0001525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001525", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IPR8", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IPR8" } ], "pmid": "" }, { "name": "brain development", "id": "GO:0007420", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007420", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IPR8", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IPR8" } ], "pmid": "" }, { "name": "blood vessel development", "id": "GO:0001568", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001568", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IPR8", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IPR8" } ], "pmid": "" }, { "name": "synaptic vesicle recycling", "id": "GO:0036465", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036465", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IPR8", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IPR8" } ], "pmid": "" }, { "name": "regulation of ARF protein signal transduction", "id": "GO:0032012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032012", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IPR8", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IPR8" } ], "pmid": "" }, { "name": "regulation of G protein-coupled receptor signaling pathway", "id": "GO:0008277", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008277", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IPR8", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IPR8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IPR8", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IPR8" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IPR8", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IPR8" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IPR8", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IPR8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IPR8", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IPR8" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IPR8", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IPR8" } ], "pmid": "" }, { "name": "postsynapse", "id": "GO:0098794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098794", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IPR8", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IPR8" } ], "pmid": "" }, { "name": "neuron projection", "id": "GO:0043005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043005", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IPR8", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IPR8" } ], "pmid": "" }, { "name": "presynapse", "id": "GO:0098793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098793", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IPR8", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IPR8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 310, "end_pos": 312, "annotation": "n_glycosylation_sequon" }, { "start_pos": 407, "end_pos": 409, "annotation": "n_glycosylation_sequon" }, { "start_pos": 456, "end_pos": 458, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.agr", "label": "AGR Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 571 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 310, "end_pos": 312 }, { "start_pos": 407, "end_pos": 409 }, { "start_pos": 456, "end_pos": 458 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": 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