{ "uniprot_canonical_ac": "A0A0R4IPM5-1", "uniprot_ac": "A0A0R4IPM5", "uniprot_id": "A0A0R4IPM5_DANRE", "mass": { "chemical_mass": 29834.0, "monoisotopic_mass": 29834.0 }, "refseq": { "ac": "XP_009294533", "name": "transcription factor Sp6 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009294533" }, "gene_names": [ { "name": "sp6", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IPM5", "id": "A0A0R4IPM5" }, { "name": "sp6", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009294533", "id": "XP_009294533" }, { "name": "zgc:77358", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009294533", "id": "XP_009294533" }, { "name": "zgc:77358", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IPM5", "id": "A0A0R4IPM5" } ], "protein_names": [ { "name": "Sp6 transcription factor", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IPM5/entry#names_and_taxonomy", "id": "A0A0R4IPM5" }, { "name": "Transcription factor Sp6 isoform X1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IPM5/entry#names_and_taxonomy", "id": "A0A0R4IPM5" }, { "name": "transcription factor Sp6 isoform X1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009294533", "id": "XP_009294533" } ], "function": [ { "annotation": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length.", "evidence": [ { "database": "RefSeq", "id": "XP_009294533", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009294533" } ] } ], "disease": [ { "disease_id": "DOID:0060945", "recommended_name": { "id": "DOID:0060945", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060945", "name": "amelogenesis imperfecta type 1K", "description": "An amelogenesis imperfecta characterized by hypoplastic enamel of all teeth that has_material_basis_in heterozygous mutation in the SP6 gene on chromosome 17q21." }, "synonyms": [ { "id": "MONDO:0031084", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0031084", "name": "amelogenesis imperfecta, IIa 1K", "description": "" }, { "id": "MONDO:0031084", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0031084", "name": "AI1K", "description": "" }, { "id": "MONDO:0031084", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0031084", "name": "amelogenesis imperfecta, IIa 1K", "description": "" }, { "id": "MONDO:0031084", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0031084", "name": "amelogenesis imperfecta, hypoplastic IIa 1K", "description": "" }, { "id": "MIM:620104", "resource": "MIM", "url": "https://www.omim.org/entry/620104", "name": "Amelogenesis imperfecta 1K", "description": "Amelogenesis imperfecta 1K" } ], "unlinked_id_list": [], "evidence": [ { "id": "0060945", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0060945" } ] }, { "disease_id": "DOID:2187", "recommended_name": { "id": "DOID:2187", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2187", "name": "amelogenesis imperfecta", "description": "A dental enamel hypoplasia characterized by abnormal enamel formation." }, "synonyms": [ { "id": "MONDO:0007092", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007092", "name": "amelogenesis imperfecta type 1B", "description": "Any amelogenesis imperfecta in which the cause of the disease is a mutation in the ENAM gene." }, { "id": "MONDO:0007092", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007092", "name": "AI1B", "description": "" }, { "id": "MONDO:0007092", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007092", "name": "ENAM amelogenesis imperfecta", "description": "" }, { "id": "MONDO:0007092", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007092", "name": "amelogenesis imperfecta caused by mutation in ENAM", "description": "" }, { "id": "MONDO:0007092", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007092", "name": "amelogenesis imperfecta caused by mutation in enam", "description": "" }, { "id": "MONDO:0007092", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007092", "name": "amelogenesis imperfecta type IB", "description": "" }, { "id": "MONDO:0007092", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007092", "name": "autosomal dominant hypoplastic local amelogenesis imperfecta", "description": "" }, { "id": "MONDO:0007092", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007092", "name": "enam amelogenesis imperfecta", "description": "" }, { "id": "MONDO:0007092", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007092", "name": "hereditary localised enamel hypoplasia", "description": "" }, { "id": "MONDO:0007092", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007092", "name": "hereditary localized enamel hypoplasia", "description": "" }, { "id": "MONDO:0007092", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007092", "name": "AIH2", "description": "" }, { "id": "MONDO:0007092", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007092", "name": "amelogenesis imperfecta, hypoplastic local, autosomal dominant", "description": "" }, { "id": "MONDO:0007092", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007092", "name": "amelogenesis imperfecta, type 1B", "description": "" }, { "id": "MONDO:0007092", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007092", "name": "amelogenesis imperfecta, type IB", "description": "" }, { "id": "MONDO:0007092", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007092", "name": "enamel hypoplasia, hereditary localised", "description": "" }, { "id": "MONDO:0007092", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007092", "name": "enamel hypoplasia, hereditary localized", "description": "" }, { "id": "MIM:104500", "resource": "MIM", "url": "https://www.omim.org/entry/104500", "name": "Amelogenesis imperfecta 1B", "description": "Amelogenesis imperfecta 1B" } ], "unlinked_id_list": [ "DOID:0111721" ], "evidence": [ { "id": "2187", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2187" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Danio rerio", "taxid": 7955, "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IPM5", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IPM5" } ], "common_name": "Zebrafish", "glygen_name": "Zebrafish", "reference_species": "Danio rerio [7955]" } ], "gene": [ { "name": "sp6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IPM5", "locus": {} } ], "crossref": [ { "id": "ZFIN:ZDB-GENE-040426-1824", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-040426-1824", "database": "AGR", "categories": [ "Protein Classification" ] }, { "id": "ENSDARG00000099880", "url": "https://bgee.org/?page=gene&gene_id=ENSDARG00000099880", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "402928", "url": "https://www.ncbi.nlm.nih.gov/gene/402928", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dre:402928", "url": "https://www.genome.jp/dbget-bin/www_bget?dre:402928", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DSRTKHM", "url": "https://omabrowser.org/oma/group/DSRTKHM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A0R4IPM5", "url": "https://www.orthodb.org/?gene=A0A0R4IPM5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q6P0Z9", "url": "https://www.orthodb.org/?gene=Q6P0Z9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23235:SF23", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23235:SF23", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "XP_009294533", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_009294533", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A0R4IPM5", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IPM5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0R4IPM5-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IPM5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6P0Z9", "url": "https://www.uniprot.org/uniprotkb/Q6P0Z9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6P0Z9-1", "url": "https://www.uniprot.org/uniprotkb/Q6P0Z9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "ZDB-GENE-040426-1824", "url": "https://zfin.org/ZDB-GENE-040426-1824", "database": "ZFIN", "categories": [ "Protein", "Organism-specific" ] } ], "sequence": { "sequence": "MAHPYDPWLRAGPPQDEVSVSGWWDVHTGAPAGWMDLQGAGLGAGPGQSGSMSSYTAEPQMCCLSPPGSGMHFPPEGFKMEPLPQDLLPLPQASASFSSEEQQDAVAAAGRPKPQRRASSRAPGQASCRCPNCLSAESLGNSGDASKRKHLHNCHIPGCGKAYVKTSHLKAHLRWHSGDRPFVCNWLFCGKRFTRSDELQRHLQTHTGAKRFGCSSCPRVFLRADHLAKHMRVHESPSQSTEETHAAAAGTSTGTSSALLRVKTETDNGDDDATLANS", "length": 278, "header": "tr|A0A0R4IPM5-1|A0A0R4IPM5_DANRE Isoform 1 of Transcription factor Sp6 isoform X1 OS=Danio rerio OX=7955 GN=sp6 PE=3 SV=1 CANONICAL=A0A0R4IPM5-1" }, "isoforms": [ { "isoform_ac": "A0A0R4IPM5-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IPM5/entry#A0A0R4IPM5-1", "sequence": { "sequence": "MAHPYDPWLRAGPPQDEVSVSGWWDVHTGAPAGWMDLQGAGLGAGPGQSGSMSSYTAEPQMCCLSPPGSGMHFPPEGFKMEPLPQDLLPLPQASASFSSEEQQDAVAAAGRPKPQRRASSRAPGQASCRCPNCLSAESLGNSGDASKRKHLHNCHIPGCGKAYVKTSHLKAHLRWHSGDRPFVCNWLFCGKRFTRSDELQRHLQTHTGAKRFGCSSCPRVFLRADHLAKHMRVHESPSQSTEETHAAAAGTSTGTSSALLRVKTETDNGDDDATLANS", "length": 278, "header": "tr|A0A0R4IPM5-1|A0A0R4IPM5_DANRE Isoform 1 of Transcription factor Sp6 isoform X1 OS=Danio rerio OX=7955 GN=sp6 PE=3 SV=1 CANONICAL=A0A0R4IPM5-1" }, "locus": {} }, { "isoform_ac": "Q6P0Z9-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IPM5/entry#Q6P0Z9-1", "sequence": { "sequence": "MAHPYDPWLRAGPPQDEVSVSGWWDVHTGAPAGWMDLQGAGLGAGPGQSGSMSSYTAEPQMCCLSPPGSGMHFPPEGFKMEPLPQDLLPLPQASASFSSEEQQDAVAAAGRPKPQRRPSSRAPGQASCRCPNCLSAESLGNSGDASKRKHLHNCHIPGCGKAYVKTSHLKAHLRWHSGDRPFVCNWLFCGKRFTRSDELQRHLQTHTGAKRFGCSSCPRVFLRADHLAKHMRVHESPSQSTEETHAAAAGTSTGTSSALLRVKTETDNGDDDATLANS", "length": 278, "header": "tr|Q6P0Z9-1|A0A0R4IPM5_DANRE Computationally mapped isoform of Transcription factor Sp6 isoform X1 OS=Danio rerio OX=7955 GN=sp6 PE=3 SV=1 CANONICAL=A0A0R4IPM5-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2002", "authors": "Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA", "evidence": [ { "database": "UniProtKB", "id": "Q6P0Z9", "url": "https://www.uniprot.org/uniprotkb/Q6P0Z9" } ], "reference": [ { "type": "PubMed", "id": "12477932", "url": "https://glygen.org/publication/PubMed/12477932" } ] }, { "title": "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.", "journal": "Brief. Bioinform.", "date": "2011", "authors": "Gaudet P, Livstone MS, Lewis SE, Thomas PD", "evidence": [ { "database": "UniProtKB", "id": "Q6P0Z9", "url": "https://www.uniprot.org/uniprotkb/Q6P0Z9" } ], "reference": [ { "type": "PubMed", "id": "21873635", "url": "https://glygen.org/publication/PubMed/21873635" } ] }, { "title": "The zebrafish reference genome sequence and its relationship to the human genome.", "journal": "Nature", "date": "2013", "authors": "Howe Kerstin, Clark Matthew D, Torroja Carlos F, Torrance James, Berthelot Camille, Muffato Matthieu, Collins John E, Humphray Sean, McLaren Karen, Matthews Lucy, McLaren Stuart, Sealy Ian, Caccamo Mario, Churcher Carol, Scott Carol, Barrett Jeffrey C, Koch Romke, Rauch Gerd-J\u00f6rg, White Simon, Chow William, Kilian Britt, Quintais Leonor T, Guerra-Assun\u00e7\u00e3o Jos\u00e9 A, Zhou Yi, Gu Yong, Yen Jennifer, Vogel Jan-Hinnerk, Eyre Tina, Redmond Seth, Banerjee Ruby, Chi Jianxiang, Fu Beiyuan, Langley Elizabeth, Maguire Sean F, Laird Gavin K, Lloyd David, Kenyon Emma, Donaldson Sarah, Sehra Harminder, Almeida-King Jeff, Loveland Jane, Trevanion Stephen, Jones Matt, Quail Mike, Willey Dave, Hunt Adrienne, Burton John, Sims Sarah, McLay Kirsten, Plumb Bob, Davis Joy, Clee Chris, Oliver Karen, Clark Richard, Riddle Clare, Elliot David, Eliott David, Threadgold Glen, Harden Glenn, Ware Darren, Begum Sharmin, Mortimore Beverley, Mortimer Beverly, Kerry Giselle, Heath Paul, Phillimore Benjamin, Tracey Alan, Corby Nicole, Dunn Matthew, Johnson Christopher, Wood Jonathan, Clark Susan, Pelan Sarah, Griffiths Guy, Smith Michelle, Glithero Rebecca, Howden Philip, Barker Nicholas, Lloyd Christine, Stevens Christopher, Harley Joanna, Holt Karen, Panagiotidis Georgios, Lovell Jamieson, Beasley Helen, Henderson Carl, Gordon Daria, Auger Katherine, Wright Deborah, Collins Joanna, Raisen Claire, Dyer Lauren, Leung Kenric, Robertson Lauren, Ambridge Kirsty, Leongamornlert Daniel, McGuire Sarah, Gilderthorp Ruth, Griffiths Coline, Manthravadi Deepa, Nichol Sarah, Barker Gary, Whitehead Siobhan, Kay Michael, Brown Jacqueline, Murnane Clare, Gray Emma, Humphries Matthew, Sycamore Neil, Barker Darren, Saunders David, Wallis Justene, Babbage Anne, Hammond Sian, Mashreghi-Mohammadi Maryam, Barr Lucy, Martin Sancha, Wray Paul, Ellington Andrew, Matthews Nicholas, Ellwood Matthew, Woodmansey Rebecca, Clark Graham, Cooper James D, Cooper James, Tromans Anthony, Grafham Darren, Skuce Carl, Pandian Richard, Andrews Robert, Harrison Elliot, Kimberley Andrew, Garnett Jane, Fosker Nigel, Hall Rebekah, Garner Patrick, Kelly Daniel, Bird Christine, Palmer Sophie, Gehring Ines, Berger Andrea, Dooley Christopher M, Ersan-\u00dcr\u00fcn Z\u00fcbeyde, Eser Cigdem, Geiger Horst, Geisler Maria, Karotki Lena, Kirn Anette, Konantz Judith, Konantz Martina, Oberl\u00e4nder Martina, Rudolph-Geiger Silke, Teucke Mathias, Lanz Christa, Raddatz G\u00fcnter, Osoegawa Kazutoyo, Zhu Baoli, Rapp Amanda, Widaa Sara, Langford Cordelia, Yang Fengtang, Schuster Stephan C, Carter Nigel P, Harrow Jennifer, Ning Zemin, Herrero Javier, Searle Steve M J, Enright Anton, Geisler Robert, Plasterk Ronald H A, Lee Charles, Westerfield Monte, de Jong Pieter J, Zon Leonard I, Postlethwait John H, N\u00fcsslein-Volhard Christiane, Hubbard Tim J P, Roest Crollius Hugues, Rogers Jane, Stemple Derek L", "evidence": [ { "database": "UniProtKB", "id": "Q6P0Z9", "url": "https://www.uniprot.org/uniprotkb/Q6P0Z9" } ], "reference": [ { "type": "PubMed", "id": "23594743", "url": "https://glygen.org/publication/PubMed/23594743" } ] }, { "title": "Understanding the complexity of epimorphic regeneration in zebrafish caudal fin tissue: A transcriptomic and proteomic approach.", "journal": "Genomics", "date": "2022", "authors": "Banu Sarena, Gaur Namami, Nair Sowmya, Ravikrishnan Tanuja, Khan Shahida, Mani Sandhya, Bharathi Swarna, Mandal Komal, Kuram Naga Anusha, Vuppaladadium Sowmya, Ravi Rowmika, Murthy Ch Lakshmi N, Quoseena Mir, Babu Nukala Sarath, Idris Mohammed M", "evidence": [ { "database": "UniProtKB", "id": "Q6P0Z9", "url": "https://www.uniprot.org/uniprotkb/Q6P0Z9" } ], "reference": [ { "type": "PubMed", "id": "35134499", "url": "https://glygen.org/publication/PubMed/35134499" } ] } ], "pathway": [ { "id": "dre:402928", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?dre:402928", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0AAA9TIJ1-1", "protein_name": "Transcription factor Sp6", "gene_name": "SP6", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MLTAVCGSLGSQHTDAPAASPPRLDLQPLQTYQGHTSPEAGDYPSPLQPGELQSLPLGPEVDFSQGYELPGASSRVTCEDLENDSPLVPGPFSKLLQPDMSHHYESWFRPTHPGTEDGSWWDLHPGTSWMDLPHAQSALTSPGHPGALQAGLGGYVGDHQLCAPPPHPHPHHLLPAAGGQHLLGPPDGAKALEAAAPESQGLDTSLDGAARPKGSRRSVPRSSGQTVCRCPNCLEAERLGAPCGPDGGKKKHLHNCHIPGCGKAYAKTSHLKAHLRWHSGDRPFVCNWLFCGKRFTRSDELQRHLQTHTGTKKFPCAVCSRVFMRSDHLAKHMKTHEGTKEEAAGAAAGEGKAGGVEPPGSKGKREAEGSAAPSN", "length": 375 }, "evidence": [ { "id": "A0A0R4IPM5", "url": "https://omabrowser.org/oma/group/A0A0R4IPM5/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "D3ZT88-1", "protein_name": "Transcription factor Sp6", "gene_name": "Sp6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLTAVCGSLGSQHTDAPHSSPPRLDLQPLQTYQGHTSPEAGDYPSPLQPGELQSLPLGPEVDFSQGYELPGASSRVTCEDLESDSPLAPGPFSKLLQPDMSHHYESWFRPTHPGTEDGSWWDLHPGTSWMDLPHTQGALTSPGHPGALQPALGGYVGDHQLCAPPPHPHPHHLLPAAGGQHLLGPPDGAKVLEAAAPESQGLDSSLDAAARPKGSRRSVPRSSGQTVCRCPNCLEAERLGAPCGPDGGKKKHLHNCHIPGCGKAYAKTSHLKAHLRWHSGDRPFVCNWLFCGKRFTRSDELQRHLQTHTGTKKFPCAVCSRVFMRSDHLAKHMKTHEGAKEEAAAAAQGEGKAGGVVESPGGKGKREAEGSSASSN", "length": 376 }, "evidence": [ { "id": "RGD:1306768", "url": "https://alliancegenome.org/gene/RGD:1306768#orthology", "database": "AGR" }, { "id": "MGI:1932575", "url": "https://alliancegenome.org/gene/MGI:1932575#orthology", "database": "AGR" }, { "id": "HGNC:14530", "url": "https://alliancegenome.org/gene/HGNC:14530#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-040426-1824", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-040426-1824#orthology", "database": "AGR" }, { "id": "A0A0R4IPM5", "url": "https://omabrowser.org/oma/group/A0A0R4IPM5/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1RWH8-1", "protein_name": "Transcription factor Sp6", "gene_name": "SP6", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLTAVCGSLGSQHTDAPPASPPRLDLQPLQTYQGHTSPEAGDYPSPLQPGELQSLPLGPEVDFSQGYELPGASSRVTCEDLESDSPLAPGPFSKLLQPDMSHHYESWFRPTHSGTEDGSWWDLHPGTSWMDLPHTQGALTSPGHPGALQAGLGGYVGDHQLCAPPPHPHPHHLLPAAGGQHLLGPPDGAKALEAAAPESQGLDTSLDGAARPKGSRRSVPRSSGQTVCRCPNCLEAERLGAPCGPDGGKKKHLHNCHIPGCGKAYAKTSHLKAHLRWHSGDRPFVCNWLFCGKRFTRSDELQRHLQTHTGTKKFPCAVCSRVFMRSDHLAKHMKTHEGAKEEAAGAAAAAGEGKAGGAEPAGGKGKREAEGSSAPSN", "length": 377 }, "evidence": [ { "id": "A0A0R4IPM5", "url": "https://omabrowser.org/oma/group/A0A0R4IPM5/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3H5U4-1", "protein_name": "Transcription factor Sp6", "gene_name": "Sp6", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MLTAVCGSLGSQHTDAPHASPPRLDLQPLQTYQGHTSPEVGDYPSPLQPGELQSLPLGPEVDFSQGYELPGASSRVTCEDLESDSPLAPGPFSKLLQPDMSHHYESWFRPTHPGAEDGSWWDLHPGTSWMDLPHTQGALTSPGHPGALQPGLGGYVGDHQLCAPPPHPHPHHLLPAAGGQHLLGPPDGAKALEAAAPESQGLDSSLDAAARPKGSRRSVPRSSGQTVCRCPNCLEAERLGAPCGPDGGKKKHLHNCHIPGCGKAYAKTSHLKAHLRWHSGDRPFVCNWLFCGKRFTRSDELQRHLQTHTGTKKFPCAVCSRVFMRSDHLAKHMKTHEGAKEEAAAAAQGEAKAGGAVEPPGGKGKREAEGSSASSN", "length": 376 }, "evidence": [ { "id": "A0A0R4IPM5", "url": "https://omabrowser.org/oma/group/A0A0R4IPM5/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "M9PJG1-1", "protein_name": "Sp1, isoform F", "gene_name": "Sp1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MLTDMTPTAGQLYGSQIPAMGMNISNIATHLQKPQVNPDHPSLRGTPLAMLAAQCNKLSNKSPPPLADAAVGKGFHPWKKSPNSPAAGSSGSSGGGGGGGGSSAGQHSPCAISAASSSSSSGSSGGQSSRSLSSSASTMVNITASRPLASSCAAVGGGSTGSSSSASGSQSSSTASAVAAAYGGDLYFPNTSTSNMDNHHMHQGLLGKVEAGAAAFGGVYSRHPYDWPFNAVTHKEAASVNSGWWDMHSAAGSWLDMGGAGMHSTMANYASENYSSALSHSLLGSGQHLLQDTYKSMLPGQGVGVGVGVGMGGFSLPHSSPSAAAAAAATAAAAAGGSPQGGSPSTPSPRSQRRYAGRATCDCPNCQEAERLGPAGVHLRKKNIHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACPVCNKRFMRSDHLAKHVKTHNGTANHQANGHNGGLKKGSSESCSDSEEAANQSGESNGLGGVGSGPQTGGAGGGGGGSSSGNGAGTLAVSGSVTTGAGAGSGTGSSNSNSNSGGSSGSVSGSVSGSGSHPGTPTSLHAHSANGTSSSLLGGGLHLATPHQMVAAGGSPVMLHQQQQQQQHQQQQQQQQQQQHQQQQQQQHQQQQQQHQQQQQQHHQQQQQHHHQQFGQQQHPHAHHLHHHAHHAHHLATGGSPGLDPSSLVDIKPPMVXGSLGPFLFTN", "length": 726 }, "evidence": [ { "id": "HGNC:14530", "url": "https://alliancegenome.org/gene/HGNC:14530#orthology", "database": "AGR" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q3SY56-1", "protein_name": "Transcription factor Sp6", "gene_name": "SP6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLTAVCGSLGSQHTEAPHASPPRLDLQPLQTYQGHTSPEAGDYPSPLQPGELQSLPLGPEVDFSQGYELPGASSRVTCEDLESDSPLAPGPFSKLLQPDMSHHYESWFRPTHPGAEDGSWWDLHPGTSWMDLPHTQGALTSPGHPGALQAGLGGYVGDHQLCAPPPHPHAHHLLPAAGGQHLLGPPDGAKALEVAAPESQGLDSSLDGAARPKGSRRSVPRSSGQTVCRCPNCLEAERLGAPCGPDGGKKKHLHNCHIPGCGKAYAKTSHLKAHLRWHSGDRPFVCNWLFCGKRFTRSDELQRHLQTHTGTKKFPCAVCSRVFMRSDHLAKHMKTHEGAKEEAAGAASGEGKAGGAVEPPGGKGKREAEGSVAPSN", "length": 376 }, "evidence": [ { "id": "RGD:1306768", "url": "https://alliancegenome.org/gene/RGD:1306768#orthology", "database": "AGR" }, { "id": "MGI:1932575", "url": "https://alliancegenome.org/gene/MGI:1932575#orthology", "database": "AGR" }, { "id": "HGNC:14530", "url": "https://alliancegenome.org/gene/HGNC:14530#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-040426-1824", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-040426-1824#orthology", "database": "AGR" }, { "id": "A0A0R4IPM5", "url": "https://omabrowser.org/oma/group/A0A0R4IPM5/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9ESX2-1", "protein_name": "Transcription factor Sp6", "gene_name": "Sp6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLTAVCGSLGSQHTDAPHASPPRLDLQPLQTYQGHTSPEAGDYPSPLQPGELQSLPLGPEVDFSQGYELPGASSRVTCEDLESDSPLAPGPFSKLLQPDMSHHYESWFRPTHPGTEDGSWWDLHPGTSWMDLPHTQGALTSPGHPGALQPALGGYVGDHQLCAPPPHPHPHHLLPAAGGQHLLGPPDGAKALEAAAQESQGLDSSLDAASRPKGSRRSVPRSSGQTVCRCPNCLEAERLGAPCGPDGGKKKHLHNCHIPGCGKAYAKTSHLKAHLRWHSGDRPFVCNWLFCGKRFTRSDELQRHLQTHTGTKKFPCAVCSRVFMRSDHLAKHMKTHEGAKEEAAAAAQGEGKAGGVVEPPGGKGKREAEGSSASSN", "length": 376 }, "evidence": [ { "id": "RGD:1306768", "url": "https://alliancegenome.org/gene/RGD:1306768#orthology", "database": "AGR" }, { "id": "MGI:1932575", "url": "https://alliancegenome.org/gene/MGI:1932575#orthology", "database": "AGR" }, { "id": "HGNC:14530", "url": "https://alliancegenome.org/gene/HGNC:14530#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-040426-1824", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-040426-1824#orthology", "database": "AGR" }, { "id": "A0A0R4IPM5", "url": "https://omabrowser.org/oma/group/A0A0R4IPM5/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IPM5", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IPM5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IPM5", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IPM5" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IPM5", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IPM5" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IPM5", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IPM5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.agr", "label": "AGR Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 4 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }