{ "uniprot_canonical_ac": "A0A0R4IP03-1", "uniprot_ac": "A0A0R4IP03", "uniprot_id": "A0A0R4IP03_DANRE", "mass": { "chemical_mass": 56930.0, "monoisotopic_mass": 56930.0 }, "refseq": { "ac": "NP_001006080", "name": "cytochrome P450 2AA8", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006080" }, "gene_names": [ { "name": "cyp2aa8", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IP03", "id": "A0A0R4IP03" }, { "name": "cyp2aa8", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006080", "id": "NP_001006080" }, { "name": "zgc:101673", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006080", "id": "NP_001006080" }, { "name": "zgc:101673", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IP03", "id": "A0A0R4IP03" } ], "protein_names": [ { "name": "Cytochrome P450 2AA8", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IP03/entry#names_and_taxonomy", "id": "A0A0R4IP03" }, { "name": "Cytochrome P450, family 2, subfamily AA, polypeptide 8", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IP03/entry#names_and_taxonomy", "id": "A0A0R4IP03" }, { "name": "cytochrome P450 2AA8", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006080", "id": "NP_001006080" } ], "function": [ { "annotation": "##Evidence-Data-START## Transcript exon combination :: GFIL01007948.1, BC083240.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505376, SAMEA3505380 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000023.1. On Jun 25, 2025 this sequence version replaced NP_001006080.2.", "evidence": [ { "database": "RefSeq", "id": "NP_001006080", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006080" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Danio rerio", "taxid": 7955, "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IP03", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IP03" } ], "common_name": "Zebrafish", "glygen_name": "Zebrafish", "reference_species": "Danio rerio [7955]" } ], "gene": [ { "name": "cyp2aa8", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IP03", "locus": {} } ], "crossref": [ { "id": "ZFIN:ZDB-GENE-041010-183", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-041010-183", "database": "AGR", "categories": [ "Protein Classification" ] }, { "id": "ENSDARG00000104540", "url": "https://bgee.org/?page=gene&gene_id=ENSDARG00000104540", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "450060", "url": "https://www.ncbi.nlm.nih.gov/gene/450060", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001128", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001128", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002401", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002401", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008069", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008069", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017972", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017972", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036396", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036396", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050182", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050182", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dre:450060", "url": "https://www.genome.jp/dbget-bin/www_bget?dre:450060", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WFRWEPE", "url": "https://omabrowser.org/oma/group/WFRWEPE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A0R4IP03", "url": "https://www.orthodb.org/?gene=A0A0R4IP03", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24300", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24300", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24300:SF326", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24300:SF326", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00067", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00067", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "NP_001006080", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006080", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A0R4IP03", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IP03", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0R4IP03-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IP03-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "ZDB-GENE-041010-183", "url": "https://zfin.org/ZDB-GENE-041010-183", "database": "ZFIN", "categories": [ "Protein", "Organism-specific" ] } ], "sequence": { "sequence": "MFSALLKLDLAFAGMTLILSLIFMFLLEIFRIHSFKSRFPPGPSPLPFVGNLPVFLKNPMEFIRSLSQYGEMTTIYLGRKPTIMLNTVQLAKEVLIQDAFAGKPSLPVLDWVSNGLGIVMVTFNHSWRQQRRFALHTLRNFGLGRKSVESRVLEESQYLIAELLKKKGKSVNPHHALQNAFSNVICSIVFGDRFDYDDKRFEHFLEILGKSMILTGSTAGQIFNFAPIIKHFPGPHQKIKKNADELSGFFQHEVKEHKKTLDPGSPRDYIDAYLLEMEKQKSNKDSTFHDENLIGSTTDLFVAGSDSTATTFRWGLLFLIQNPDVQERCHKEIVQVLGYDRLPSMEDRDRLPYTLATVHEIQRCANLAPFGLIHETIQPTKLQGYDLPRGTTIIVNLTAIFSNKENWKHPDTFNPENFLDESGQFSKHESFIPFSLGVRVCLGETLARTELFLFITALLQRIRFSLPPDAKPMDMDGILSVLRYPQNFSFICCSRDTKE", "length": 499, "header": "tr|A0A0R4IP03-1|A0A0R4IP03_DANRE Isoform 1 of Cytochrome P450, family 2, subfamily AA, polypeptide 8 OS=Danio rerio OX=7955 GN=cyp2aa8 PE=3 SV=1 CANONICAL=A0A0R4IP03-1" }, "isoforms": [ { "isoform_ac": "A0A0R4IP03-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IP03/entry#A0A0R4IP03-1", "sequence": { "sequence": "MFSALLKLDLAFAGMTLILSLIFMFLLEIFRIHSFKSRFPPGPSPLPFVGNLPVFLKNPMEFIRSLSQYGEMTTIYLGRKPTIMLNTVQLAKEVLIQDAFAGKPSLPVLDWVSNGLGIVMVTFNHSWRQQRRFALHTLRNFGLGRKSVESRVLEESQYLIAELLKKKGKSVNPHHALQNAFSNVICSIVFGDRFDYDDKRFEHFLEILGKSMILTGSTAGQIFNFAPIIKHFPGPHQKIKKNADELSGFFQHEVKEHKKTLDPGSPRDYIDAYLLEMEKQKSNKDSTFHDENLIGSTTDLFVAGSDSTATTFRWGLLFLIQNPDVQERCHKEIVQVLGYDRLPSMEDRDRLPYTLATVHEIQRCANLAPFGLIHETIQPTKLQGYDLPRGTTIIVNLTAIFSNKENWKHPDTFNPENFLDESGQFSKHESFIPFSLGVRVCLGETLARTELFLFITALLQRIRFSLPPDAKPMDMDGILSVLRYPQNFSFICCSRDTKE", "length": 499, "header": "tr|A0A0R4IP03-1|A0A0R4IP03_DANRE Isoform 1 of Cytochrome P450, family 2, subfamily AA, polypeptide 8 OS=Danio rerio OX=7955 GN=cyp2aa8 PE=3 SV=1 CANONICAL=A0A0R4IP03-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish.", "journal": "BMC Genomics", "date": "2010", "authors": "Goldstone Jared V, McArthur Andrew G, Kubota Akira, Zanette Juliano, Parente Thiago, J\u00f6nsson Maria E, Nelson David R, Stegeman John J", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IP03", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IP03" } ], "reference": [ { "type": "PubMed", "id": "21087487", "url": "https://glygen.org/publication/PubMed/21087487" } ] }, { "title": "Phylogenetic and functional analysis of the vertebrate cytochrome p450 2 family.", "journal": "J. Mol. Evol.", "date": "2011", "authors": "Kirischian Nina, McArthur Andrew G, Jesuthasan Caroline, Krattenmacher Birgit, Wilson Joanna Y", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IP03", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IP03" } ], "reference": [ { "type": "PubMed", "id": "21116621", "url": "https://glygen.org/publication/PubMed/21116621" } ] }, { "title": "An osteosarcoma zebrafish model implicates Mmp-19 and Ets-1 as well as reduced host immune response in angiogenesis and migration.", "journal": "J. Pathol.", "date": "2012", "authors": "Mohseny Alexander B, Xiao Wei, Carvalho Ralph, Spaink Herman P, Hogendoorn Pancras C W, Cleton-Jansen Anne-Marie", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IP03", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IP03" } ], "reference": [ { "type": "PubMed", "id": "22297719", "url": "https://glygen.org/publication/PubMed/22297719" } ] }, { "title": "Interferon regulatory factor 6 promotes differentiation of the periderm by activating expression of Grainyhead-like 3.", "journal": "J. Invest. Dermatol.", "date": "2013", "authors": "de la Garza Gabriel, Schleiffarth Jack Robert, Dunnwald Martine, Mankad Anuj, Weirather Jason L, Bonde Gregory, Butcher Stephen, Mansour Tamer A, Kousa Youssef A, Fukazawa Cindy F, Houston Douglas W, Manak J Robert, Schutte Brian C, Wagner Daniel S, Cornell Robert A", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IP03", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IP03" } ], "reference": [ { "type": "PubMed", "id": "22931925", "url": "https://glygen.org/publication/PubMed/22931925" } ] }, { "title": "The zebrafish reference genome sequence and its relationship to the human genome.", "journal": "Nature", "date": "2013", "authors": "Howe Kerstin, Clark Matthew D, Torroja Carlos F, Torrance James, Berthelot Camille, Muffato Matthieu, Collins John E, Humphray Sean, McLaren Karen, Matthews Lucy, McLaren Stuart, Sealy Ian, Caccamo Mario, Churcher Carol, Scott Carol, Barrett Jeffrey C, Koch Romke, Rauch Gerd-J\u00f6rg, White Simon, Chow William, Kilian Britt, Quintais Leonor T, Guerra-Assun\u00e7\u00e3o Jos\u00e9 A, Zhou Yi, Gu Yong, Yen Jennifer, Vogel Jan-Hinnerk, Eyre Tina, Redmond Seth, Banerjee Ruby, Chi Jianxiang, Fu Beiyuan, Langley Elizabeth, Maguire Sean F, Laird Gavin K, Lloyd David, Kenyon Emma, Donaldson Sarah, Sehra Harminder, Almeida-King Jeff, Loveland Jane, Trevanion Stephen, Jones Matt, Quail Mike, Willey Dave, Hunt Adrienne, Burton John, Sims Sarah, McLay Kirsten, Plumb Bob, Davis Joy, Clee Chris, Oliver Karen, Clark Richard, Riddle Clare, Elliot David, Eliott David, Threadgold Glen, Harden Glenn, Ware Darren, Begum Sharmin, Mortimore Beverley, Mortimer Beverly, Kerry Giselle, Heath Paul, Phillimore Benjamin, Tracey Alan, Corby Nicole, Dunn Matthew, Johnson Christopher, Wood Jonathan, Clark Susan, Pelan Sarah, Griffiths Guy, Smith Michelle, Glithero Rebecca, Howden Philip, Barker Nicholas, Lloyd Christine, Stevens Christopher, Harley Joanna, Holt Karen, Panagiotidis Georgios, Lovell Jamieson, Beasley Helen, Henderson Carl, Gordon Daria, Auger Katherine, Wright Deborah, Collins Joanna, Raisen Claire, Dyer Lauren, Leung Kenric, Robertson Lauren, Ambridge Kirsty, Leongamornlert Daniel, McGuire Sarah, Gilderthorp Ruth, Griffiths Coline, Manthravadi Deepa, Nichol Sarah, Barker Gary, Whitehead Siobhan, Kay Michael, Brown Jacqueline, Murnane Clare, Gray Emma, Humphries Matthew, Sycamore Neil, Barker Darren, Saunders David, Wallis Justene, Babbage Anne, Hammond Sian, Mashreghi-Mohammadi Maryam, Barr Lucy, Martin Sancha, Wray Paul, Ellington Andrew, Matthews Nicholas, Ellwood Matthew, Woodmansey Rebecca, Clark Graham, Cooper James D, Cooper James, Tromans Anthony, Grafham Darren, Skuce Carl, Pandian Richard, Andrews Robert, Harrison Elliot, Kimberley Andrew, Garnett Jane, Fosker Nigel, Hall Rebekah, Garner Patrick, Kelly Daniel, Bird Christine, Palmer Sophie, Gehring Ines, Berger Andrea, Dooley Christopher M, Ersan-\u00dcr\u00fcn Z\u00fcbeyde, Eser Cigdem, Geiger Horst, Geisler Maria, Karotki Lena, Kirn Anette, Konantz Judith, Konantz Martina, Oberl\u00e4nder Martina, Rudolph-Geiger Silke, Teucke Mathias, Lanz Christa, Raddatz G\u00fcnter, Osoegawa Kazutoyo, Zhu Baoli, Rapp Amanda, Widaa Sara, Langford Cordelia, Yang Fengtang, Schuster Stephan C, Carter Nigel P, Harrow Jennifer, Ning Zemin, Herrero Javier, Searle Steve M J, Enright Anton, Geisler Robert, Plasterk Ronald H A, Lee Charles, Westerfield Monte, de Jong Pieter J, Zon Leonard I, Postlethwait John H, N\u00fcsslein-Volhard Christiane, Hubbard Tim J P, Roest Crollius Hugues, Rogers Jane, Stemple Derek L", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IP03", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IP03" } ], "reference": [ { "type": "PubMed", "id": "23594743", "url": "https://glygen.org/publication/PubMed/23594743" } ] }, { "title": "The cytochrome P450 2AA gene cluster in zebrafish (Danio rerio): expression of CYP2AA1 and CYP2AA2 and response to phenobarbital-type inducers.", "journal": "Toxicol. Appl. Pharmacol.", "date": "2013", "authors": "Kubota Akira, Bainy Afonso C D, Woodin Bruce R, Goldstone Jared V, Stegeman John J", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IP03", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IP03" } ], "reference": [ { "type": "PubMed", "id": "23726801", "url": "https://glygen.org/publication/PubMed/23726801" } ] }, { "title": "Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.", "journal": "BMC Genomics", "date": "2016", "authors": "Pasquier Jeremy, Cabau C\u00e9dric, Nguyen Thaovi, Jouanno Elodie, Severac Dany, Braasch Ingo, Journot Laurent, Pontarotti Pierre, Klopp Christophe, Postlethwait John H, Guiguen Yann, Bobe Julien", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IP03", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IP03" } ], "reference": [ { "type": "PubMed", "id": "27189481", "url": "https://glygen.org/publication/PubMed/27189481" } ] }, { "title": "Cortisol-treated zebrafish embryos develop into pro-inflammatory adults with aberrant immune gene regulation.", "journal": "Biol. Open", "date": "2016", "authors": "Hartig Ellen I, Zhu Shusen, King Benjamin L, Coffman James A", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IP03", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IP03" } ], "reference": [ { "type": "PubMed", "id": "27444789", "url": "https://glygen.org/publication/PubMed/27444789" } ] }, { "title": "Nine co-localized cytochrome P450 genes of the CYP2N, CYP2AD, and CYP2P gene families in the mangrove killifish Kryptolebias marmoratus genome: Identification and expression in response to B[alpha]P, BPA, OP, and NP.", "journal": "Aquat. Toxicol.", "date": "2017", "authors": "Puthumana Jayesh, Kim Bo-Mi, Jeong Chang-Bum, Kim Duck-Hyun, Kang Hye-Min, Jung Jee-Hyun, Kim Il-Chan, Hwang Un-Ki, Lee Jae-Seong", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IP03", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IP03" } ], "reference": [ { "type": "PubMed", "id": "28411468", "url": "https://glygen.org/publication/PubMed/28411468" } ] }, { "title": "Tris(1,3-dichloro-2-propyl) phosphate disrupts dorsoventral patterning in zebrafish embryos.", "journal": "PeerJ", "date": "2017", "authors": "Dasgupta Subham, Vliet Sara M, Kupsco Allison, Leet Jessica K, Altomare Diego, Volz David C", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IP03", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IP03" } ], "reference": [ { "type": "PubMed", "id": "29259843", "url": "https://glygen.org/publication/PubMed/29259843" } ] }, { "title": "Cytochrome P450 2AA molecular clone, expression pattern, and different regulation by fish oil and lard oil in diets of grass carp (Ctenopharyngodon idella).", "journal": "Fish Physiol. Biochem.", "date": "2018", "authors": "Shi Xiao-Chen, Sun Jian, Jin Ai, Ji Hong, Yu Hai-Bo, Li Yang, Li Xue-Xian, Liu Pin, Li Chao, Huang Ji-Qin", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IP03", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IP03" } ], "reference": [ { "type": "PubMed", "id": "29725939", "url": "https://glygen.org/publication/PubMed/29725939" } ] } ], "pathway": [ { "id": "dre:450060", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?dre:450060", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "iron ion binding", "id": "GO:0005506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IP03", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IP03" } ], "pmid": "" }, { "name": "heme binding", "id": "GO:0020037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020037", "evidence": [ { 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