{ "uniprot_canonical_ac": "A0A0R4IP02-1", "uniprot_ac": "A0A0R4IP02", "uniprot_id": "A0A0R4IP02_DANRE", "mass": { "chemical_mass": 73917.0, "monoisotopic_mass": 73917.0 }, "refseq": { "ac": "XP_005165331", "name": "kelch-like protein 13 isoform X4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005165331" }, "gene_names": [ { "name": "klhl13", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IP02", "id": "A0A0R4IP02" }, { "name": "klhl13", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005165331", "id": "XP_005165331" }, { "name": "wu:fc15b07; zgc:163008", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005165331", "id": "XP_005165331" }, { "name": "wu:fc15b07", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IP02", "id": "A0A0R4IP02" }, { "name": "zgc:163008", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IP02", "id": "A0A0R4IP02" } ], "protein_names": [ { "name": "Kelch-like family member 13", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IP02/entry#names_and_taxonomy", "id": "A0A0R4IP02" }, { "name": "Kelch-like protein 13 isoform X4", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IP02/entry#names_and_taxonomy", "id": "A0A0R4IP02" }, { "name": "kelch-like protein 13 isoform X4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005165331", "id": "XP_005165331" } ], "function": [ { "annotation": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length.", "evidence": [ { "database": "RefSeq", "id": "XP_005165331", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005165331" } ] }, { "annotation": "Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.", "evidence": [ { "database": "UniProtKB", "id": "A0A8M2BCL7", "url": "https://www.uniprot.org/uniprotkb/A0A8M2BCL7#function" }, { "database": "UniProtKB", "id": "ARBA00056604", "url": "https://www.uniprot.org/uniprotkb/ARBA00056604#function" }, { "database": "UniProtKB", "id": "A0A8M1NDF2", "url": "https://www.uniprot.org/uniprotkb/A0A8M1NDF2#function" }, { "database": "UniProtKB", "id": "A0A8M1P401", "url": "https://www.uniprot.org/uniprotkb/A0A8M1P401#function" }, { "database": "UniProtKB", "id": "A0A0R4IP02", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IP02#function" }, { "database": "UniProtKB", "id": "F1REQ9", "url": "https://www.uniprot.org/uniprotkb/F1REQ9#function" }, { "database": "UniProtKB", "id": "A0A0R4ICR0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ICR0#function" }, { "database": "UniProtKB", "id": "A0A8M2BCI0", "url": "https://www.uniprot.org/uniprotkb/A0A8M2BCI0#function" }, { "database": "UniProtKB", "id": "A0A2R8Q9E7", "url": "https://www.uniprot.org/uniprotkb/A0A2R8Q9E7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Danio rerio", "taxid": 7955, "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IP02", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IP02" } ], "common_name": "Zebrafish", "glygen_name": "Zebrafish", "reference_species": "Danio rerio [7955]" } ], "gene": [ { "name": "klhl13", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IP02", "locus": {} } ], "crossref": [ { "id": "ZFIN:ZDB-GENE-030131-2671", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-030131-2671", "database": "AGR", "categories": [ "Protein Classification" ] }, { "id": "ENSDARG00000086463", "url": "https://bgee.org/?page=gene&gene_id=ENSDARG00000086463", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSDARG00000103786", "url": "https://bgee.org/?page=gene&gene_id=ENSDARG00000103786", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "ENSDARG00000115063", "url": "https://bgee.org/?page=gene&gene_id=ENSDARG00000115063", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18239", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18239", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18449", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18449", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "323951", "url": "https://www.ncbi.nlm.nih.gov/gene/323951", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000210", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006652", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006652", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011333", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011705", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011705", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015915", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017096", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017096", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dre:323951", "url": "https://www.genome.jp/dbget-bin/www_bget?dre:323951", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IIAMEFY", "url": "https://omabrowser.org/oma/group/IIAMEFY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "RAQEWKS", "url": "https://omabrowser.org/oma/group/RAQEWKS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "XGITHDT", "url": "https://omabrowser.org/oma/group/XGITHDT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A0R4ICR0", "url": "https://www.orthodb.org/?gene=A0A0R4ICR0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A0R4IP02", "url": "https://www.orthodb.org/?gene=A0A0R4IP02", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A2R8Q9E7", "url": "https://www.orthodb.org/?gene=A0A2R8Q9E7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A8M1NDF2", "url": "https://www.orthodb.org/?gene=A0A8M1NDF2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A8M1P401", "url": "https://www.orthodb.org/?gene=A0A8M1P401", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A8M2BCI0", "url": "https://www.orthodb.org/?gene=A0A8M2BCI0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A8M2BCL7", "url": "https://www.orthodb.org/?gene=A0A8M2BCL7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1REQ9", "url": "https://www.orthodb.org/?gene=F1REQ9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45632", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45632", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45632:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45632:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00651", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00651", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF01344", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01344", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF07707", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07707", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF24681", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF24681", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "XP_005165331", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005165331", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A0R4ICR0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ICR0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0R4ICR0-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ICR0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0R4IP02", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IP02", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0R4IP02-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IP02-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A2R8Q9E7", "url": "https://www.uniprot.org/uniprotkb/A0A2R8Q9E7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A2R8Q9E7-1", "url": "https://www.uniprot.org/uniprotkb/A0A2R8Q9E7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8M1NDF2", "url": "https://www.uniprot.org/uniprotkb/A0A8M1NDF2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8M1NDF2-1", "url": "https://www.uniprot.org/uniprotkb/A0A8M1NDF2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8M1P401", "url": "https://www.uniprot.org/uniprotkb/A0A8M1P401", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8M1P401-1", "url": "https://www.uniprot.org/uniprotkb/A0A8M1P401-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8M2BCI0", "url": "https://www.uniprot.org/uniprotkb/A0A8M2BCI0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8M2BCI0-1", "url": "https://www.uniprot.org/uniprotkb/A0A8M2BCI0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8M2BCL7", "url": "https://www.uniprot.org/uniprotkb/A0A8M2BCL7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8M2BCL7-1", "url": "https://www.uniprot.org/uniprotkb/A0A8M2BCL7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1REQ9", "url": "https://www.uniprot.org/uniprotkb/F1REQ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1REQ9-1", "url": "https://www.uniprot.org/uniprotkb/F1REQ9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "ZDB-GENE-030131-2671", "url": "https://zfin.org/ZDB-GENE-030131-2671", "database": "ZFIN", "categories": [ "Protein", "Organism-specific" ] } ], "sequence": { "sequence": "MPLKWKSGSPVSWKFPVPVLKTSRSSPLSPAYISLVEDDDAQMMKVSLGCSEMGLSSHLQASKTGNTRFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVAGDGDEAFPVHRAMMASSSDYFKAMFTGGMKEQDLMCIKLHGVNRIGLKKIIDFIYTAKLSLNMENLQDTLEAASFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTYNLTEVDKYVNNFILKNFPSLLGTGEFVKLPFERLAFVLSSNSLKHCSELDLFKSACRWLRYEEGRMEYAAKLMRNIRFPLMSPTELINHVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSERTAIRSDNTHLVTLGGVLRQQLVVSKELRLFDEKAHEWKALAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRYDPRYNKWIQVACLNEKRTFFHLSALKGYLYAVGGRNAAGELATVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGYMYISGGITHDTFQKELMCFDPDADKWTQKAPMTTVRGLHCMCTVGDRLYVIGGNHFRGTSDYDDVLSCEYYSPALDLWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTLTVFPPEDLSLAGSPSRESPLSAP", "length": 658, "header": "tr|A0A0R4IP02-1|A0A0R4IP02_DANRE Isoform 1 of Kelch-like protein 13 isoform X4 OS=Danio rerio OX=7955 GN=klhl13 PE=1 SV=2 CANONICAL=A0A0R4IP02-1" }, "isoforms": [ { "isoform_ac": "A0A0R4ICR0-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IP02/entry#A0A0R4ICR0-1", "sequence": { "sequence": "MDHPVHRGDTMSIGLHDRYCAIHQHSFVVWTTHSLLAASPTYHLTGSLVEDDDAQMMKVSLGCSEMGLSSHLQASKTGNTRFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVAGDGDEAFPVHRAMMASSSDYFKAMFTGGMKEQDLMCIKLHGVNRIGLKKIIDFIYTAKLSLNMENLQDTLEAASFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTYNLTEVDKYVNNFILKNFPSLLGTGEFVKLPFERLAFVLSSNSLKHCSELDLFKSACRWLRYEEGRMEYAAKLMRNIRFPLMSPTELINHVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSERTAIRSDNTHLVTLGGVLRQQLVVSKELRLFDEKAHEWKALAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRYDPRYNKWIQVACLNEKRTFFHLSALKGYLYAVGGRNAAGELATVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGYMYISGGITHDTFQKELMCFDPDADKWTQKAPMTTVRGLHCMCTVGDRLYVIGGNHFRGTSDYDDVLSCEYYSPALDLWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTLTVFPPEDLSLAGSPSRESPLSAP", "length": 671, "header": "tr|A0A0R4ICR0-1|A0A0R4IP02_DANRE Computationally mapped isoform of Kelch-like protein 13 isoform X4 OS=Danio rerio OX=7955 GN=klhl13 PE=1 SV=1 CANONICAL=A0A0R4IP02-1" }, "locus": {} }, { "isoform_ac": "A0A0R4IP02-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IP02/entry#A0A0R4IP02-1", "sequence": { "sequence": "MPLKWKSGSPVSWKFPVPVLKTSRSSPLSPAYISLVEDDDAQMMKVSLGCSEMGLSSHLQASKTGNTRFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVAGDGDEAFPVHRAMMASSSDYFKAMFTGGMKEQDLMCIKLHGVNRIGLKKIIDFIYTAKLSLNMENLQDTLEAASFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTYNLTEVDKYVNNFILKNFPSLLGTGEFVKLPFERLAFVLSSNSLKHCSELDLFKSACRWLRYEEGRMEYAAKLMRNIRFPLMSPTELINHVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSERTAIRSDNTHLVTLGGVLRQQLVVSKELRLFDEKAHEWKALAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRYDPRYNKWIQVACLNEKRTFFHLSALKGYLYAVGGRNAAGELATVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGYMYISGGITHDTFQKELMCFDPDADKWTQKAPMTTVRGLHCMCTVGDRLYVIGGNHFRGTSDYDDVLSCEYYSPALDLWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTLTVFPPEDLSLAGSPSRESPLSAP", "length": 658, "header": "tr|A0A0R4IP02-1|A0A0R4IP02_DANRE Isoform 1 of Kelch-like protein 13 isoform X4 OS=Danio rerio OX=7955 GN=klhl13 PE=1 SV=2 CANONICAL=A0A0R4IP02-1" }, "locus": {} }, { "isoform_ac": "A0A2R8Q9E7-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IP02/entry#A0A2R8Q9E7-1", "sequence": { "sequence": "MPLKWKSGSPVSWKFPVPVLKTSRSSPLSPAYIHQHSFVVWTTHSLLAASPTYHLTGSLVEDDDAQMMKVSLGCSEMGLSSHLQASKTGNTRFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVAGDGDEAFPVHRAMMASSSDYFKAMFTGGMKEQDLMCIKLHGVNRIGLKKIIDFIYTAKLSLNMENLQDTLEAASFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTYNLTEVDKYVNNFILKNFPSLLGTGEFVKLPFERLAFVLSSNSLKHCSELDLFKSACRWLRYEEGRMEYAAKLMRNIRFPLMSPTELINHVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSERTAIRSDNTHLVTLGGVLRQQLVVSKELRLFDEKAHEWKALAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRYDPRYNKWIQVACLNEKRTFFHLSALKGYLYAVGGRNAAGELATVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGYMYISGGITHDTFQKELMCFDPDADKWTQKAPMTTVRGLHCMCTVGDRLYVIGGNHFRGTSDYDDVLSCEYYSPALDLWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTLTVFPPEDLSLAGSPSRESPLSAP", "length": 682, "header": "tr|A0A2R8Q9E7-1|A0A0R4IP02_DANRE Computationally mapped isoform of Kelch-like protein 13 isoform X4 OS=Danio rerio OX=7955 GN=klhl13 PE=1 SV=1 CANONICAL=A0A0R4IP02-1" }, "locus": {} }, { "isoform_ac": "A0A8M1NDF2-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IP02/entry#A0A8M1NDF2-1", "sequence": { "sequence": "MDHPVHRGDTMSIGLHDRSLVEDDDAQMMKVSLGCSEMGLSSHLQASKTGNTRFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVAGDGDEAFPVHRAMMASSSDYFKAMFTGGMKEQDLMCIKLHGVNRIGLKKIIDFIYTAKLSLNMENLQDTLEAASFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTYNLTEVDKYVNNFILKNFPSLLGTGEFVKLPFERLAFVLSSNSLKHCSELDLFKSACRWLRYEEGRMEYAAKLMRNIRFPLMSPTELINHVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSERTAIRSDNTHLVTLGGVLRQQLVVSKELRLFDEKAHEWKALAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRYDPRYNKWIQVACLNEKRTFFRLSALKGYLYAVGGRNAAGELATVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGYMYISGGITHDTFQKELMCFDPDADKWTQKAPMTTVRGLHCMCTVGDRLYVIGGNHFRGTSDYDDVLSCEYYSPALDLWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTLTVFPPEDLSLAGSPSRESPLSAP", "length": 643, "header": "tr|A0A8M1NDF2-1|A0A0R4IP02_DANRE Computationally mapped isoform of Kelch-like protein 13 isoform X4 OS=Danio rerio OX=7955 GN=klhl13 PE=1 SV=1 CANONICAL=A0A0R4IP02-1" }, "locus": {} }, { "isoform_ac": "A0A8M1P401-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IP02/entry#A0A8M1P401-1", "sequence": { "sequence": "MDHPVHRGDTMSIGLHDRYCAIHQHSFVVWTTHSLLAGAPTYHLTGSLVEDDDAQMMKVSLGCSEMGLSSHLQASKTGNTRFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVAGDGDEAFPVHRAMMASSSDYFKAMFTGGMKEQDLMCIKLHGVNRIGLKKIIDFIYTAKLSLNMENLQDTLEAASFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTYNLTEVDKYVNNFILKNFPSLLGTGEFVKLPFERLAFVLSSNSLKHCSELDLFKSACRWLRYEEGRMEYAAKLMRNIRFPLMSPTELINHVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSERTAIRSDNTHLVTLGGVLRQQLVVSKELRLFDEKAHEWKALAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRYDPRYNKWIQVACLNEKRTFFHLSALKGYLYAVGGRNAAGELATVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGYMYISGGITHDTFQKELMCFDPDADKWTQKAPMTTVRGLHCMCTVGDRLYVIGGNHFRGTSDYDDVLSCEYYSPALDLWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTLTVFPPEDLSLAGSPSRESPLSAP", "length": 671, "header": "tr|A0A8M1P401-1|A0A0R4IP02_DANRE Computationally mapped isoform of Kelch-like protein 13 isoform X4 OS=Danio rerio OX=7955 GN=klhl13 PE=1 SV=1 CANONICAL=A0A0R4IP02-1" }, "locus": {} }, { "isoform_ac": "A0A8M2BCI0-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IP02/entry#A0A8M2BCI0-1", "sequence": { "sequence": "MDHPVHRGDTMSIGLHDSHQHSFVVWTTHSLLAASPTYHLTGSLVEDDDAQMMKVSLGCSEMGLSSHLQASKTGNTRFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVAGDGDEAFPVHRAMMASSSDYFKAMFTGGMKEQDLMCIKLHGVNRIGLKKIIDFIYTAKLSLNMENLQDTLEAASFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTYNLTEVDKYVNNFILKNFPSLLGTGEFVKLPFERLAFVLSSNSLKHCSELDLFKSACRWLRYEEGRMEYAAKLMRNIRFPLMSPTELINHVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSERTAIRSDNTHLVTLGGVLRQQLVVSKELRLFDEKAHEWKALAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRYDPRYNKWIQVACLNEKRTFFHLSALKGYLYAVGGRNAAGELATVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGYMYISGGITHDTFQKELMCFDPDADKWTQKAPMTTVRGLHCMCTVGDRLYVIGGNHFRGTSDYDDVLSCEYYSPALDLWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTLTVFPPEDLSLAGSPSRESPLSAP", "length": 667, "header": "tr|A0A8M2BCI0-1|A0A8M2BCI0_DANRE Computationally mapped isoform of Kelch-like protein 13 isoform X3 OS=Danio rerio OX=7955 GN=klhl13 PE=1 SV=1 CANONICAL=A0A0R4IP02-1" }, "locus": {} }, { "isoform_ac": "A0A8M2BCL7-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IP02/entry#A0A8M2BCL7-1", "sequence": { "sequence": "MDHPVHRGDTMSIGLHDRYCAISLVEDDDAQMMKVSLGCSEMGLSSHLQASKTGNTRFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVAGDGDEAFPVHRAMMASSSDYFKAMFTGGMKEQDLMCIKLHGVNRIGLKKIIDFIYTAKLSLNMENLQDTLEAASFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTYNLTEVDKYVNNFILKNFPSLLGTGEFVKLPFERLAFVLSSNSLKHCSELDLFKSACRWLRYEEGRMEYAAKLMRNIRFPLMSPTELINHVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSERTAIRSDNTHLVTLGGVLRQQLVVSKELRLFDEKAHEWKALAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRYDPRYNKWIQVACLNEKRTFFHLSALKGYLYAVGGRNAAGELATVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGYMYISGGITHDTFQKELMCFDPDADKWTQKAPMTTVRGLHCMCTVGDRLYVIGGNHFRGTSDYDDVLSCEYYSPALDLWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTLTVFPPEDLSLAGSPSRESPLSAP", "length": 647, "header": "tr|A0A8M2BCL7-1|A0A8M2BCL7_DANRE Computationally mapped isoform of Kelch-like protein 13 isoform X5 OS=Danio rerio OX=7955 GN=klhl13 PE=1 SV=1 CANONICAL=A0A0R4IP02-1" }, "locus": {} }, { "isoform_ac": "F1REQ9-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IP02/entry#F1REQ9-1", "sequence": { "sequence": "MDHPVHRGDTMSIGLHDRSLVEDDDAQMMKVSLGCSEMGLSSHLQASKTGNTRFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVAGDGDEAFPVHRAMMASSSDYFKAMFTGGMKEQDLMCIKLHGVNRIGLKKIIDFIYTAKLSLNMENLQDTLEAASFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTYNLTEVDKYVNNFILKNFPSLLGTGEFVKLPFERLAFVLSSNSLKHCSELDLFKSACRWLRYEEGRMEYAAKLMRNIRFPLMSPTELINHVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSERTAIRSDNTHLVTLGGVLRQQLVVSKELRLFDEKAHEWKALAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRYDPRYNKWIQVACLNEKRTFFHLSALKGYLYAVGGRNAAGELATVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGYMYISGGITHDTFQKELMCFDPDADKWTQKAPMTTVRGLHCMCTVGDRLYVIGGNHFRGTSDYDDVLSCEYYSPALDLWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTLTVFPPEDLSLAGSPSRESPLSAP", "length": 643, "header": "tr|F1REQ9-1|A0A0R4IP02_DANRE Computationally mapped isoform of Kelch-like protein 13 isoform X4 OS=Danio rerio OX=7955 GN=klhl13 PE=1 SV=2 CANONICAL=A0A0R4IP02-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "The zebrafish reference genome sequence and its relationship to the human genome.", "journal": "Nature", "date": "2013", "authors": "Howe Kerstin, Clark Matthew D, Torroja Carlos F, Torrance James, Berthelot Camille, Muffato Matthieu, Collins John E, Humphray Sean, McLaren Karen, Matthews Lucy, McLaren Stuart, Sealy Ian, Caccamo Mario, Churcher Carol, Scott Carol, Barrett Jeffrey C, Koch Romke, Rauch Gerd-J\u00f6rg, White Simon, Chow William, Kilian Britt, Quintais Leonor T, Guerra-Assun\u00e7\u00e3o Jos\u00e9 A, Zhou Yi, Gu Yong, Yen Jennifer, Vogel Jan-Hinnerk, Eyre Tina, Redmond Seth, Banerjee Ruby, Chi Jianxiang, Fu Beiyuan, Langley Elizabeth, Maguire Sean F, Laird Gavin K, Lloyd David, Kenyon Emma, Donaldson Sarah, Sehra Harminder, Almeida-King Jeff, Loveland Jane, Trevanion Stephen, Jones Matt, Quail Mike, Willey Dave, Hunt Adrienne, Burton John, Sims Sarah, McLay Kirsten, Plumb Bob, Davis Joy, Clee Chris, Oliver Karen, Clark Richard, Riddle Clare, Elliot David, Eliott David, Threadgold Glen, Harden Glenn, Ware Darren, Begum Sharmin, Mortimore Beverley, Mortimer Beverly, Kerry Giselle, Heath Paul, Phillimore Benjamin, Tracey Alan, Corby Nicole, Dunn Matthew, Johnson Christopher, Wood Jonathan, Clark Susan, Pelan Sarah, Griffiths Guy, Smith Michelle, Glithero Rebecca, Howden Philip, Barker Nicholas, Lloyd Christine, Stevens Christopher, Harley Joanna, Holt Karen, Panagiotidis Georgios, Lovell Jamieson, Beasley Helen, Henderson Carl, Gordon Daria, Auger Katherine, Wright Deborah, Collins Joanna, Raisen Claire, Dyer Lauren, Leung Kenric, Robertson Lauren, Ambridge Kirsty, Leongamornlert Daniel, McGuire Sarah, Gilderthorp Ruth, Griffiths Coline, Manthravadi Deepa, Nichol Sarah, Barker Gary, Whitehead Siobhan, Kay Michael, Brown Jacqueline, Murnane Clare, Gray Emma, Humphries Matthew, Sycamore Neil, Barker Darren, Saunders David, Wallis Justene, Babbage Anne, Hammond Sian, Mashreghi-Mohammadi Maryam, Barr Lucy, Martin Sancha, Wray Paul, Ellington Andrew, Matthews Nicholas, Ellwood Matthew, Woodmansey Rebecca, Clark Graham, Cooper James D, Cooper James, Tromans Anthony, Grafham Darren, Skuce Carl, Pandian Richard, Andrews Robert, Harrison Elliot, Kimberley Andrew, Garnett Jane, Fosker Nigel, Hall Rebekah, Garner Patrick, Kelly Daniel, Bird Christine, Palmer Sophie, Gehring Ines, Berger Andrea, Dooley Christopher M, Ersan-\u00dcr\u00fcn Z\u00fcbeyde, Eser Cigdem, Geiger Horst, Geisler Maria, Karotki Lena, Kirn Anette, Konantz Judith, Konantz Martina, Oberl\u00e4nder Martina, Rudolph-Geiger Silke, Teucke Mathias, Lanz Christa, Raddatz G\u00fcnter, Osoegawa Kazutoyo, Zhu Baoli, Rapp Amanda, Widaa Sara, Langford Cordelia, Yang Fengtang, Schuster Stephan C, Carter Nigel P, Harrow Jennifer, Ning Zemin, Herrero Javier, Searle Steve M J, Enright Anton, Geisler Robert, Plasterk Ronald H A, Lee Charles, Westerfield Monte, de Jong Pieter J, Zon Leonard I, Postlethwait John H, N\u00fcsslein-Volhard Christiane, Hubbard Tim J P, Roest Crollius Hugues, Rogers Jane, Stemple Derek L", "evidence": [ { "database": "UniProtKB", "id": "A0A8M1P401", "url": "https://www.uniprot.org/uniprotkb/A0A8M1P401" } ], "reference": [ { "type": "PubMed", "id": "23594743", "url": "https://glygen.org/publication/PubMed/23594743" } ] }, { "title": "Saltatory evolution of the ectodermal neural cortex gene family at the vertebrate origin.", "journal": "Genome Biol. Evol.", "date": "2013", "authors": "Feiner Nathalie, Murakami Yasunori, Breithut Lisa, Mazan Sylvie, Meyer Axel, Kuraku Shigehiro", "evidence": [ { "database": "UniProtKB", "id": "A0A8M1P401", "url": "https://www.uniprot.org/uniprotkb/A0A8M1P401" } ], "reference": [ { "type": "PubMed", "id": "23843192", "url": "https://glygen.org/publication/PubMed/23843192" } ] }, { "title": "RFX transcription factors are essential for hearing in mice.", "journal": "Nat. Commun.", "date": "2015", "authors": "Elkon Ran, Milon Beatrice, Morrison Laura, Shah Manan, Vijayakumar Sarath, Racherla Manoj, Leitch Carmen C, Silipino Lorna, Hadi Shadan, Weiss-Gayet Mich\u00e8le, Barras Emmanu\u00e8le, Schmid Christoph D, Ait-Lounis Aouatef, Barnes Ashley, Song Yang, Eisenman David J, Eliyahu Efrat, Frolenkov Gregory I, Strome Scott E, Durand B\u00e9n\u00e9dicte, Zaghloul Norann A, Jones Sherri M, Reith Walter, Hertzano Ronna", "evidence": [ { "database": "UniProtKB", "id": "A0A8M1P401", "url": "https://www.uniprot.org/uniprotkb/A0A8M1P401" } ], "reference": [ { "type": "PubMed", "id": "26469318", "url": "https://glygen.org/publication/PubMed/26469318" } ] } ], "pathway": [ { "id": "dre:323951", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?dre:323951", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287ACD9-1", "protein_name": "Kelch-like protein 13 isoform d", "gene_name": "KLHL13", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MDHLHRGESVAAILRNRSLVEEEDQHMKLSLGSSEMGLSSHLQSSKAGTTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP", "length": 639 }, "evidence": [ { "id": "A0A0R4IP02", "url": "https://omabrowser.org/oma/group/A0A0R4IP02/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8I6A140-1", "protein_name": "Kelch-like family member 9", "gene_name": "Klhl13", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDILHRGELVAAILRNRSLVEEEDQHLKLCLGSEMGLSSHLQSCKAGSTRIFTSNSHSSVVLQGFDQLRLDGLLCDVTLMPGDTDDAYPVHRVMMASASDYFKAMFTGGMKEQELMCIKLHGVSRVGLRKIIDFIYTAKLSLNMDTLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYHLTEVDKYVNSFVLKNFAALLSTGEFLKLPFERLAFVLSSNSLKRCTELELFKATCRWLRLEEPRMDVAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMMPFMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKTHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWIQVASLNEKRTFFHLSALKGFLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMNEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGDRLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIASMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKNEWHKVFDLPESLGGIRACTLTVYPPEENTPSPSRESPLSGP", "length": 638 }, "evidence": [ { "id": "HGNC:22931", "url": "https://alliancegenome.org/gene/HGNC:22931#orthology", "database": "AGR" }, { "id": "MGI:1914705", "url": "https://alliancegenome.org/gene/MGI:1914705#orthology", "database": "AGR" }, { "id": "A0A0R4IP02", "url": "https://omabrowser.org/oma/group/A0A0R4IP02/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A6QQY2-1", "protein_name": "Kelch-like protein 13", "gene_name": "KLHL13", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MPLKWKTSSPAIWKFPVPVLKTSRSTPLSPAYISLVEEEDQHMKLSLGSSEMGLSSHLQSSKAGTTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP", "length": 655 }, "evidence": [ { "id": "A0A0R4IP02", "url": "https://omabrowser.org/oma/group/A0A0R4IP02/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "F1MXI0-1", "protein_name": "Kelch like family member 9", "gene_name": "KLHL9", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MKVSLGNGEMGVSAHLQPCKAGTTRFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKAACRWLRLEDPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLRQQLVVSKELRMYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWTQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTLTVFPPEENPGSPSRESPLSAPSDHS", "length": 617 }, "evidence": [ { "id": "A0A0R4IP02", "url": "https://omabrowser.org/oma/group/A0A0R4IP02/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "Q6ZPT1-1", "protein_name": "Kelch-like protein 9", "gene_name": "Klhl9", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKVSLGNGDMGVSAHLQPCKSGTTRFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGEEIFPVHRAMMASASDYFKAMFTGGMKEKDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLNTGEFLKLPFERLAFVLSSNSLKHCSELELFKAACRWLRLEDPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLRQQLVVSKELRMYDERAQEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWTQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTLTVFPPEENPGSPSRESPLSAPSDHS", "length": 617 }, "evidence": [ { "id": "A0A0R4IP02", "url": "https://omabrowser.org/oma/group/A0A0R4IP02/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q80TF4-1", "protein_name": "Kelch-like protein 13", "gene_name": "Klhl13", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPLKWKTSSPAIWKFPVPVLKTSRSTPLSPAYISLVEEEDQHLKLCLGSEMGLSSHLQSCKAGSTRIFTSNSHSSVVLQGFDQLRLDGLLCDVTLMPGDTDDAYPVHRVMMASASDYFKAMFTGGMKEQELMCIKLHGVSRVGLRKIIDFIYTAKLSLNMDTLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYHLTEVDKYVNSFVLKNFAALLSTGEFLKLPFERLAFVLSSNSLKRCTELDLFKATCRWLRLEEPRMDVAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMMPFMQPVMQSDRTAIRSDTTRLVTLGGVLRQQLVVSKELRMYDEKTHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWIQVASLNEKRTFFHLSALKGFLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMNEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWTQKAPMTTVRGLHCMCTVGDRLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIASMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKNEWHKVFDLPESLGGIRACTLTVYPPEEATPSPSRESPLSGP", "length": 654 }, "evidence": [ { "id": "HGNC:22931", "url": "https://alliancegenome.org/gene/HGNC:22931#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-030131-2671", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-030131-2671#orthology", "database": "AGR" }, { "id": "MGI:1914705", "url": "https://alliancegenome.org/gene/MGI:1914705#orthology", "database": "AGR" }, { "id": "A0A0R4IP02", "url": "https://omabrowser.org/oma/group/A0A0R4IP02/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9P2J3-1", "protein_name": "Kelch-like protein 9", "gene_name": "KLHL9", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKVSLGNGEMGVSAHLQPCKAGTTRFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKAACRWLRLEDPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLRQQLVVSKELRMYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTLTVFPPEENPGSPSRESPLSAPSDHS", "length": 617 }, "evidence": [ { "id": "A0A0R4IP02", "url": "https://omabrowser.org/oma/group/A0A0R4IP02/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9P2N7-1", "protein_name": "Kelch-like protein 13", "gene_name": "KLHL13", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPLKWKTSSPAIWKFPVPVLKTSRSTPLSPAYISLVEEEDQHMKLSLGGSEMGLSSHLQSSKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP", "length": 655 }, "evidence": [ { "id": "HGNC:22931", "url": "https://alliancegenome.org/gene/HGNC:22931#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-030131-2671", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-030131-2671#orthology", "database": "AGR" }, { "id": "MGI:1914705", "url": "https://alliancegenome.org/gene/MGI:1914705#orthology", "database": "AGR" }, { "id": "A0A0R4IP02", "url": "https://omabrowser.org/oma/group/A0A0R4IP02/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VRA7-1", "protein_name": "Kelch-like protein diablo", "gene_name": "Dmel\\CG1812", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAATPAPAVTPAATATSAAAKIPVNPVSPEEETLLRGLNKLRNEEKLTDVTLIVEEHRFKAHRVVLAASSDYFCAMFADCAMIESRKDEINLYGIKARAMGSIIDYIYTSMLELNYDNIEEILAAATHVQVREVIDRCTIFLGAKIEMENCLAIAGMADIYGIMDLSERAYRYMCAHFEEFATTSDFKEMKVDQLRFILSSNYPIDVAEQDLVRLVCSFAIEQQLNESALGDLLRLIKWQHISYKSVDELRNMNCSLDKGKQLPLPTSYYNRIKQEHMGHLLNGVVSLKDQSLPQGPTNMRGMELCLLKIGGFEWNGLTNVIMCFSPKKMNWYELTAIPHIDQCNFGTAVLNNKLFIVGGAYDVFLKEYIHPFGFCYCPLRNTWMTIAPIQQDRCRFSLNAVGTQHLYAVGGILDDDNEEALRMISNVERYDIAKNVWTYMPSLQENRSQHAGVVVGDKLYISGGVHLANILASMWVFDTKTEVWQELASMPTPCCDHVLVAVDNRIYACGGWHESLTEWRVLVEHIYAYDIETNTWSVETKIPAPKFYTGVTAMGRTIFFVGGLDSTESIDRASAETMAYDLDTKEWWHEKDSWDSPNDVWESTCVAIYVPNCDA", "length": 616 }, "evidence": [ { "id": "HGNC:22931", "url": "https://alliancegenome.org/gene/HGNC:22931#orthology", "database": "AGR" }, { "id": "MGI:1914705", "url": "https://alliancegenome.org/gene/MGI:1914705#orthology", "database": "AGR" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IP02", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IP02" } ], "pmid": "" }, { "name": "regulation of cytokinesis", "id": "GO:0032465", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032465", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IP02", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IP02" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cullin family protein binding", "id": "GO:0097602", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097602", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IP02", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IP02" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Cul3-RING ubiquitin ligase complex", "id": "GO:0031463", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031463", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IP02", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IP02" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 208, "end_pos": 210, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.agr", "label": "AGR Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 208, "end_pos": 210 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }