{ "uniprot_canonical_ac": "A0A0R4IMF6-1", "uniprot_ac": "A0A0R4IMF6", "uniprot_id": "A0A0R4IMF6_DANRE", "mass": { "chemical_mass": 69413.0, "monoisotopic_mass": 69413.0 }, "refseq": { "ac": "NP_001092707", "name": "eukaryotic translation initiation factor 4Ba", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092707" }, "gene_names": [ { "name": "eif4ba", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IMF6", "id": "A0A0R4IMF6" }, { "name": "eif4ba", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092707", "id": "NP_001092707" }, { "name": "eif4b", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092707", "id": "NP_001092707" }, { "name": "eif4b", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IMF6", "id": "A0A0R4IMF6" } ], "protein_names": [ { "name": "Eukaryotic translation initiation factor 4B", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IMF6/entry#names_and_taxonomy", "id": "A0A0R4IMF6" }, { "name": "eukaryotic translation initiation factor 4Ba", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092707", "id": "NP_001092707" }, { "name": "eukaryotic translation initiation factor 4B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092707", "id": "NP_001092707" } ], "function": [ { "annotation": "##Evidence-Data-START## Transcript exon combination :: BC129148.1, GFIL01009497.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000023.1. On Jun 25, 2025 this sequence version replaced NP_001092707.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.", "evidence": [ { "database": "RefSeq", "id": "NP_001092707", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092707" } ] }, { "annotation": "Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.", "evidence": [ { "database": "UniProtKB", "id": "F1QAA4", "url": "https://www.uniprot.org/uniprotkb/F1QAA4#function" }, { "database": "UniProtKB", "id": "ARBA00057062", "url": "https://www.uniprot.org/uniprotkb/ARBA00057062#function" }, { "database": "UniProtKB", "id": "A0A0R4IMF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IMF6#function" }, { "database": "UniProtKB", "id": "A0A8M2B8R4", "url": "https://www.uniprot.org/uniprotkb/A0A8M2B8R4#function" } ] } ], "disease": [ { "disease_id": "DOID:0060041", "recommended_name": { "id": "DOID:0060041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060041", "name": "autism spectrum disorder", "description": "A pervasive developmental disorder that is a spectrum of psychological conditions. The disease has_symptom widespread abnormalities of social interactions and communication, has_symptom severely restricted interests and has_symptom highly repetitive behavior." }, "synonyms": [], "unlinked_id_list": [], "evidence": [ { "id": "0060041", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0060041" } ] }, { "disease_id": "DOID:1470", "recommended_name": { "id": "DOID:1470", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1470", "name": "major depressive disorder", "description": "A depressive disorder that is characterized by at least two weeks of loss of interest or pleasure in normally enjoyable activities or depressed mood along with additional cognitive or somatic impairments such as appetite or weight changes, sleep difficulties, psychomotor agitation or retardation, fatigue or loss of energy, diminished ability to think or concentrate, feelings of worthlessness or excessive guilt, and suicidality." }, "synonyms": [ { "id": "DOID:1470", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1470", "name": "clinical depression", "description": "" }, { "id": "DOID:1470", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1470", "name": "recurrent major depression", "description": "" }, { "id": "DOID:1470", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1470", "name": "single major depressive episode", "description": "" }, { "id": "DOID:1470", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1470", "name": "unipolar depression", "description": "" }, { "id": "DOID:1470", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1470", "name": "major depression", "description": "" }, { "id": "MONDO:0012100", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012100", "name": "major depressive disorder 2", "description": "" }, { "id": "MONDO:0012100", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012100", "name": "MDD2", "description": "" }, { "id": "MONDO:0012100", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012100", "name": "major depressive disorder 2", "description": "" }, { "id": "MONDO:0012100", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012100", "name": "major depressive disorder type 2", "description": "" }, { "id": "MONDO:0012100", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012100", "name": "unipolar depression 2", "description": "" }, { "id": "MONDO:0012050", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012050", "name": "major depressive disorder 1", "description": "" }, { "id": "MONDO:0012050", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012050", "name": "MDD1", "description": "" }, { "id": "MONDO:0012050", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012050", "name": "major depressive disorder 1", "description": "" }, { "id": "MONDO:0012050", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012050", "name": "major depressive disorder type 1", "description": "" }, { "id": "MONDO:0012050", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012050", "name": "unipolar depression 1", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "1470", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1470" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Danio rerio", "taxid": 7955, "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IMF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IMF6" } ], "common_name": "Zebrafish", "glygen_name": "Zebrafish", "reference_species": "Danio rerio [7955]" } ], "gene": [ { "name": "eif4ba", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IMF6", "locus": {} } ], "crossref": [ { "id": "ZFIN:ZDB-GENE-060629-1", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-060629-1", "database": "AGR", "categories": [ "Protein Classification" ] }, { "id": "ENSDARG00000017439", "url": "https://bgee.org/?page=gene&gene_id=ENSDARG00000017439", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12402", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12402", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "553214", "url": "https://www.ncbi.nlm.nih.gov/gene/553214", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033107", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033107", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dre:553214", "url": "https://www.genome.jp/dbget-bin/www_bget?dre:553214", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WTTVPNK", "url": "https://omabrowser.org/oma/group/WTTVPNK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A0R4IMF6", "url": "https://www.orthodb.org/?gene=A0A0R4IMF6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A8M2B8R4", "url": "https://www.orthodb.org/?gene=A0A8M2B8R4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "F1QAA4", "url": "https://www.orthodb.org/?gene=F1QAA4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23236", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23236", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23236:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23236:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00076", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "NP_001092707", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092707", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A0R4IMF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IMF6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0R4IMF6-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IMF6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8M2B8R4", "url": "https://www.uniprot.org/uniprotkb/A0A8M2B8R4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8M2B8R4-1", "url": "https://www.uniprot.org/uniprotkb/A0A8M2B8R4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1QAA4", "url": "https://www.uniprot.org/uniprotkb/F1QAA4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1QAA4-1", "url": "https://www.uniprot.org/uniprotkb/F1QAA4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "ZDB-GENE-060629-1", "url": "https://zfin.org/ZDB-GENE-060629-1", "database": "ZFIN", "categories": [ "Protein", "Organism-specific" ] } ], "sequence": { "sequence": "MAASAKKNKKKGKTLTLTDFLAEDSGGNAPPSYAPPKPTSWADETDDLEGDVTTSWHTEDEVYRAPPIDRSILPTAPRAAREPNVDRSRLPRSPPYTAFLGNLPYDVTEDSIKNFFRGLSISAVRLPREPSNPERLKGFGYAEFDDVESLLQALSLNEENLGNRRIRVDIADQSNEKERDDRSVSGRDRNRSDRDMGPDKTDSDWRARPKSEADDGPRRDDAFAERSKDRYDSDRHREGQRWDNDRYDGGRDRYRERYDDRERRDYDRGFDSRSGGRRPFGSGFRRDYDDRRDDFRGSGDRYGDREERFERRDERRDDRGPPQRPKLNLKPRSVPKDEEPSRGPSASSGRAASIFGGAKPVDTAAKEREVEERLKKEQDRLQRQLEEDKNRGPERKPRERHPSWRSEDQGTERSRTGSESSQTGNPPSRGQRRRESERSVENEVFSSRDEELSSHGSQSPASKQEALPLKVVPAPPPKENAWAKRSAMSAGSTESDSKPAVSPSSAAPPRSLPGSGDVPQRNKDENKADGVRRDRGPSRGRGGASGSGAGRGRGDAASRDRRKETDRKDARRERDLRPAPEPKKFEESPSPKFSSASKYAALLMDGEQAGEEDGGN", "length": 616, "header": "tr|A0A0R4IMF6-1|A0A0R4IMF6_DANRE Isoform 1 of Eukaryotic translation initiation factor 4B OS=Danio rerio OX=7955 GN=eif4ba PE=1 SV=1 CANONICAL=A0A0R4IMF6-1" }, "isoforms": [ { "isoform_ac": "A0A0R4IMF6-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IMF6/entry#A0A0R4IMF6-1", "sequence": { "sequence": "MAASAKKNKKKGKTLTLTDFLAEDSGGNAPPSYAPPKPTSWADETDDLEGDVTTSWHTEDEVYRAPPIDRSILPTAPRAAREPNVDRSRLPRSPPYTAFLGNLPYDVTEDSIKNFFRGLSISAVRLPREPSNPERLKGFGYAEFDDVESLLQALSLNEENLGNRRIRVDIADQSNEKERDDRSVSGRDRNRSDRDMGPDKTDSDWRARPKSEADDGPRRDDAFAERSKDRYDSDRHREGQRWDNDRYDGGRDRYRERYDDRERRDYDRGFDSRSGGRRPFGSGFRRDYDDRRDDFRGSGDRYGDREERFERRDERRDDRGPPQRPKLNLKPRSVPKDEEPSRGPSASSGRAASIFGGAKPVDTAAKEREVEERLKKEQDRLQRQLEEDKNRGPERKPRERHPSWRSEDQGTERSRTGSESSQTGNPPSRGQRRRESERSVENEVFSSRDEELSSHGSQSPASKQEALPLKVVPAPPPKENAWAKRSAMSAGSTESDSKPAVSPSSAAPPRSLPGSGDVPQRNKDENKADGVRRDRGPSRGRGGASGSGAGRGRGDAASRDRRKETDRKDARRERDLRPAPEPKKFEESPSPKFSSASKYAALLMDGEQAGEEDGGN", "length": 616, "header": "tr|A0A0R4IMF6-1|A0A0R4IMF6_DANRE Isoform 1 of Eukaryotic translation initiation factor 4B OS=Danio rerio OX=7955 GN=eif4ba PE=1 SV=1 CANONICAL=A0A0R4IMF6-1" }, "locus": {} }, { "isoform_ac": "A0A8M2B8R4-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IMF6/entry#A0A8M2B8R4-1", "sequence": { "sequence": "MAASAKKNKKKGKTLTLTDFLAEDSGGNAPPSYAPPKPTSWADETDDLEGDVTTSWHTEDEVYRAPPIDRSILPTAPRAAREPNVDRSRLPRSPPYTAFLGNLPYDVTEDSIKNFFRGLSISAVRLPREPSNPERLKGFGYAEFDDVESLLQALSLNEENLGNRRIRVDIADQSNEKERDDRSVSGRDRNRSDRDMGPDKTDSDWRARPKSEADDGPRRDDAFAERSKDRYDSDRHREGQRWDNDRYDGGRDRYRERYDDRERRDYDRGFDSRSGGRRPFGSGFRRDYDDRRDDFRGSGDRYGDREERFERRDERRDDRGPPQRPKLNLKPRSVPKDEEPSRGPSASSGRAASIFGGAKPVDTAAKEREVEERLKKEQDRLQRQLEEDKNRGPERKPRERHPSWRSEDQGTERSRTGSESSQTGNPPSRGQRRRESERSVENEVFSSRDEELSSHGSQSPASKQEALPLKVVPAPPPKENAWAKRSAMSAGSTESDSKPAVSPSSAAPPRSLPGSGDVPQRNKDENKADGVRRDRGPSRGRGGASGSGAGRGRGDAASRDRRKETDRNSAQPVNTQPC", "length": 578, "header": "tr|A0A8M2B8R4-1|A0A8M2B8R4_DANRE Computationally mapped isoform of Eukaryotic translation initiation factor 4B OS=Danio rerio OX=7955 GN=eif4ba PE=1 SV=1 CANONICAL=A0A0R4IMF6-1" }, "locus": {} }, { "isoform_ac": "F1QAA4-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IMF6/entry#F1QAA4-1", "sequence": { "sequence": "MAASAKKNKKKGKTLTLTDFLAEDSGGNAPPSYAPPKPTSWADETDDLEGDVTTSWHTEDEVYRAPPIDRSILPTAPRAAREPNVDRSRLPRSPPYTAFLGNLPYDVTEDSIKNFFRGLSISAVRLPREPSNPERLKGFGYAEFDDVESLLQALSLNEENLGNRRIRVDIADQSNEKERDDRSVSGRDRNRSDRDMGPDKTDSDWRARPKSEADDGPRRDDAFAERSKDRYDSDRHREGQRWDNDRYDGGRDRYRERYDDRERRDYDRGFDSRSGGRRPFGSGFRRDYDDRRDDFRGSGDRYGDREERFERRDERRDDRGPPQRPKLNLKPRSVPKDEEPSRGPSASSGRAASIFGGAKPVDTAAKEREVEERLKKEQDRLQRQLEEDKNRGPERKPRERHPSWRSEDQGTERSRTGSESSQTGNPPSRGQRRRESERSVENEVFSSRDEELSSHGSQSPASKQEALPLKVVPAPPPKENAWAKRSAMSAGSTESDSKPAVSPSSAAPPRSLPGSGDVPQRNKEIQLSQ", "length": 529, "header": "tr|F1QAA4-1|A0A0R4IMF6_DANRE Computationally mapped isoform of Eukaryotic translation initiation factor 4B OS=Danio rerio OX=7955 GN=eif4ba PE=1 SV=1 CANONICAL=A0A0R4IMF6-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "The zebrafish reference genome sequence and its relationship to the human genome.", "journal": "Nature", "date": "2013", "authors": "Howe Kerstin, Clark Matthew D, Torroja Carlos F, Torrance James, Berthelot Camille, Muffato Matthieu, Collins John E, Humphray Sean, McLaren Karen, Matthews Lucy, McLaren Stuart, Sealy Ian, Caccamo Mario, Churcher Carol, Scott Carol, Barrett Jeffrey C, Koch Romke, Rauch Gerd-J\u00f6rg, White Simon, Chow William, Kilian Britt, Quintais Leonor T, Guerra-Assun\u00e7\u00e3o Jos\u00e9 A, Zhou Yi, Gu Yong, Yen Jennifer, Vogel Jan-Hinnerk, Eyre Tina, Redmond Seth, Banerjee Ruby, Chi Jianxiang, Fu Beiyuan, Langley Elizabeth, Maguire Sean F, Laird Gavin K, Lloyd David, Kenyon Emma, Donaldson Sarah, Sehra Harminder, Almeida-King Jeff, Loveland Jane, Trevanion Stephen, Jones Matt, Quail Mike, Willey Dave, Hunt Adrienne, Burton John, Sims Sarah, McLay Kirsten, Plumb Bob, Davis Joy, Clee Chris, Oliver Karen, Clark Richard, Riddle Clare, Elliot David, Eliott David, Threadgold Glen, Harden Glenn, Ware Darren, Begum Sharmin, Mortimore Beverley, Mortimer Beverly, Kerry Giselle, Heath Paul, Phillimore Benjamin, Tracey Alan, Corby Nicole, Dunn Matthew, Johnson Christopher, Wood Jonathan, Clark Susan, Pelan Sarah, Griffiths Guy, Smith Michelle, Glithero Rebecca, Howden Philip, Barker Nicholas, Lloyd Christine, Stevens Christopher, Harley Joanna, Holt Karen, Panagiotidis Georgios, Lovell Jamieson, Beasley Helen, Henderson Carl, Gordon Daria, Auger Katherine, Wright Deborah, Collins Joanna, Raisen Claire, Dyer Lauren, Leung Kenric, Robertson Lauren, Ambridge Kirsty, Leongamornlert Daniel, McGuire Sarah, Gilderthorp Ruth, Griffiths Coline, Manthravadi Deepa, Nichol Sarah, Barker Gary, Whitehead Siobhan, Kay Michael, Brown Jacqueline, Murnane Clare, Gray Emma, Humphries Matthew, Sycamore Neil, Barker Darren, Saunders David, Wallis Justene, Babbage Anne, Hammond Sian, Mashreghi-Mohammadi Maryam, Barr Lucy, Martin Sancha, Wray Paul, Ellington Andrew, Matthews Nicholas, Ellwood Matthew, Woodmansey Rebecca, Clark Graham, Cooper James D, Cooper James, Tromans Anthony, Grafham Darren, Skuce Carl, Pandian Richard, Andrews Robert, Harrison Elliot, Kimberley Andrew, Garnett Jane, Fosker Nigel, Hall Rebekah, Garner Patrick, Kelly Daniel, Bird Christine, Palmer Sophie, Gehring Ines, Berger Andrea, Dooley Christopher M, Ersan-\u00dcr\u00fcn Z\u00fcbeyde, Eser Cigdem, Geiger Horst, Geisler Maria, Karotki Lena, Kirn Anette, Konantz Judith, Konantz Martina, Oberl\u00e4nder Martina, Rudolph-Geiger Silke, Teucke Mathias, Lanz Christa, Raddatz G\u00fcnter, Osoegawa Kazutoyo, Zhu Baoli, Rapp Amanda, Widaa Sara, Langford Cordelia, Yang Fengtang, Schuster Stephan C, Carter Nigel P, Harrow Jennifer, Ning Zemin, Herrero Javier, Searle Steve M J, Enright Anton, Geisler Robert, Plasterk Ronald H A, Lee Charles, Westerfield Monte, de Jong Pieter J, Zon Leonard I, Postlethwait John H, N\u00fcsslein-Volhard Christiane, Hubbard Tim J P, Roest Crollius Hugues, Rogers Jane, Stemple Derek L", "evidence": [ { "database": "UniProtKB", "id": "F1QAA4", "url": "https://www.uniprot.org/uniprotkb/F1QAA4" } ], "reference": [ { "type": "PubMed", "id": "23594743", "url": "https://glygen.org/publication/PubMed/23594743" } ] }, { "title": "Fertility Enhancement but Premature Ovarian Failure in esr1-Deficient Female Zebrafish.", "journal": "Front. Endocrinol.", "date": "2018", "authors": "Chen Yu, Tang Haipei, Wang Le, He Jianan, Guo Yin, Liu Yun, Liu Xiaochun, Lin Haoran", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IMF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IMF6" } ], "reference": [ { "type": "PubMed", "id": "30319547", "url": "https://glygen.org/publication/PubMed/30319547" } ] }, { "title": "Cardioprotective responses to aerobic exercise-induced physiological hypertrophy in zebrafish heart.", "journal": "J. Physiol. Sci.", "date": "2021", "authors": "Chen Zhanglin, Zhou Zuoqiong, Peng Xiyang, Sun Chenchen, Yang Dong, Li Chengli, Zhu Runkang, Zhang Ping, Zheng Lan, Tang Changfa", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IMF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IMF6" } ], "reference": [ { "type": "PubMed", "id": "34749643", "url": "https://glygen.org/publication/PubMed/34749643" } ] } ], "pathway": [ { "id": "dre:553214", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?dre:553214", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1Q8G3-1", "protein_name": "Eukaryotic translation initiation factor 4B", "gene_name": "eif4bb", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAASAKKNKKKGKTLTLNDFLADETGGNAPPSFPTTKATSWADETDDLEGDVSTSWHTVEDTYRAPPIDRSILPTAPRAAREPNVDRSRLPRSPPYTAFLGNLPYDVSEESIRDFFRGLAISAVRLPREPNNPERLKGFGYAEFDDIESLLRALSLNEENLGNRRIRVDIADQSNDKERDSGMMSGRDRDRDRGRGMDSGPDKTDSDWRARPSSDQDDGPRKDDGYGDKSRDRYESDRFRDGPRRDDRFSGRDRYDDRDRKDRYDDRDRRDRFDDRGSRDYDRGGFDSRGGGRRGFSSGFRRDYEDRRDGDRFGDREDRRDEGREERGPPQRPKLNLKPRSIPKEEEQSGSVSPQSNPTNTSRASSIFGAAKPVDTAAKEREVEERLKKEQERLQRQLEEDKNRPSERRPRDRDPSWRSEEPPKERQHTGSESSHPKGSRCRDDEHSENEVFSGQESEPISPTSPSPTSNQGSLPLKVMPAPPPKENAWAKRSLGGGANEKEAPPSANAPINKSAPRPNRSADERESGKDENRVDGVRKDKVLPAGRGGGGGVGRGGGSVEGVGKGRGVDCPNKEKRREPSDRKEVKRDKDPRIASEPKKYEESAPPKFSSASKYAALLMDGDQGEEGDGEE", "length": 632 }, "evidence": [ { "id": "HGNC:3285", "url": "https://alliancegenome.org/gene/HGNC:3285#orthology", "database": "AGR" }, { "id": "MGI:95304", "url": "https://alliancegenome.org/gene/MGI:95304#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "P23588-1", "protein_name": "Eukaryotic translation initiation factor 4B", "gene_name": "EIF4B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAASAKKKNKKGKTISLTDFLAEDGGTGGGSTYVSKPVSWADETDDLEGDVSTTWHSNDDDVYRAPPIDRSILPTAPRAAREPNIDRSRLPKSPPYTAFLGNLPYDVTEESIKEFFRGLNISAVRLPREPSNPERLKGFGYAEFEDLDSLLSALSLNEESLGNRRIRVDVADQAQDKDRDDRSFGRDRNRDSDKTDTDWRARPATDSFDDYPPRRGDDSFGDKYRDRYDSDRYRDGYRDGYRDGPRRDMDRYGGRDRYDDRGSRDYDRGYDSRIGSGRRAFGSGYRRDDDYRGGGDRYEDRYDRRDDRSWSSRDDYSRDDYRRDDRGPPQRPKLNLKPRSTPKEDDSSASTSQSTRAASIFGGAKPVDTAAREREVEERLQKEQEKLQRQLDEPKLERRPRERHPSWRSEETQERERSRTGSESSQTGTSTTSSRNARRRESEKSLENETLNKEEDCHSPTSKPPKPDQPLKVMPAPPPKENAWVKRSSNPPARSQSSDTEQQSPTSGGGKVAPAQPSEEGPGRKDENKVDGMNAPKGQTGNSSRGPGDGGNRDHWKESDRKDGKKDQDSRSAPEPKKPEENPASKFSSASKYAALSVDGEDENEGEDYAE", "length": 611 }, "evidence": [ { "id": "HGNC:3285", "url": "https://alliancegenome.org/gene/HGNC:3285#orthology", "database": "AGR" }, { "id": "MGI:95304", "url": "https://alliancegenome.org/gene/MGI:95304#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-060629-1", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-060629-1#orthology", "database": "AGR" }, { "id": "A0A0R4IMF6", "url": "https://omabrowser.org/oma/group/A0A0R4IMF6/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P34167-1", "protein_name": "Eukaryotic translation initiation factor 4B", "gene_name": "TIF3", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MAPPKKTVKKMDLTSFLNDDTFGSSWAEEDVDLNKITIPIETANANTIPLSELAHAKNNSNNTRSGGFGGSFGGRSRLDPALGGGSSDRREEYPVPDAPPYRAVINNIPWDITPEGVQAWVEDGLVKPEAVEEVVLPKNLRDPTRLKGNAFVTLKERADLVAVLKFNGTKLNERTVYVSVAAPRRGGGADVDWSSARGSNFQGDGREDAPDLDWGAARGSNFRGPRREREEVDIDWTAARGSNFQGSSRPPRREREEVDIDWSAARGSNFQGSSRPPRREREEPDIDWSAARGSNFQSSSRPPRREREEPDIDWSAARGSNFQSSSRPPRREREKEEPALDWGAARGAQFGKPQQTKNTYKDRSLTNKKTTDEQPKIQKSVYDVLRTEDDDEDEEAEKQNGDAKENKVDAAVEKLQDKTAQLTVEDGDNWEVVGKK", "length": 436 }, "evidence": [ { "id": "HGNC:3285", "url": "https://alliancegenome.org/gene/HGNC:3285#orthology", "database": "AGR" }, { "id": "MGI:95304", "url": "https://alliancegenome.org/gene/MGI:95304#orthology", "database": "AGR" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q7PLL3-1", "protein_name": "LD33831p", "gene_name": "eIF4B", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MASAGKKGKKNKGTVISLQSFLCNSDAPVGTTQVSKKIRNLDGDDSDDGSGTLPLVYQLPTAPRANRIFDDNSIPHKAPFIAYINNLPFDANEDDLYEFFEGINLISLRLPREDGENGRSRGFGYVELENREDLIHVLSLPDPSIKGRRIRIELSNENDQQSRQKSNRRFDGFGNNGDNRDSGNWRRDSQNNGSNFGYSSNFERSFNRERKSLPDRDDVNTPGSWRTSARPQSIDTSPTRREVEQVSEKYREGRVKIADRYSREETSKVEEERPKLNLKPRTLPLPDVKTIEFEKCDVDEFNLDKQGGTSSLNVFGSAKPVDTAARELEIEQRLALARKQDKGRREQGLNEKLAELQVDKNDNESLSATVSWRTNQDYKESDKINKCPGEKQRDEEIHRLNHARGQFNRPELLREKPNANGESKRDCRNDRSVSKKTSQNDLVLQSSNKYSGLDNEGSE", "length": 459 }, "evidence": [ { "id": "HGNC:3285", "url": "https://alliancegenome.org/gene/HGNC:3285#orthology", "database": "AGR" }, { "id": "MGI:95304", "url": "https://alliancegenome.org/gene/MGI:95304#orthology", "database": "AGR" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q8BGD9-1", "protein_name": "Eukaryotic translation initiation factor 4B", "gene_name": "Eif4b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAASAKKKNKKGKTISLTDFLAEDGGTGGGSTYVPKPVSWADETDDLEGDVSTTWHSNDDDVYRAPPIDRSILPTAPRAAREPNIDRSRLPKSPPYTAFLGNLPYDVTEDSIKDFFRGLNISAVRLPREPSNPDRLKGFGYAEFEDLDSLLSALSLNEESLGNRRIRVDVADQAQDKDRDDRSFGRDRNRDSDKTDTDWRARPTTDSFDDYPPRRGDDSFGDKYRDRYDSDRYRDGYRDGYRDGPRRDMDRYGGRDRYDDRGSRDYDRGYDSRIGSGRRAFGSGYRRDDDYRGGGDRYEDRYDRRDDRSWSSRDDYSRDDYRRDDRGPPQRPRLNLKPRSAPKEDDASASTSQSSRAASIFGGAKPVDTAAREREVEERLQKEQEKLQRQLDEPKLDRRPRERHPSWRSEETQERERSRTGSESSQTGASATSGRNTRRRESEKSLENETLNKEEDCHSPTSKPPKPDQPLKVMPAPPPKENAWVKRSSNPPARSQSSDTEQPSPTSGGGKVAAVQPPEEGPSRKDGNKVDVVGATQGQAGSCSRGPGDGGSRDHWKDLDRKDGKKDQDSRSAPEPKKPEENPASKFSSASKYAALSVDGEDEDEGDDCTE", "length": 611 }, "evidence": [ { "id": "HGNC:3285", "url": "https://alliancegenome.org/gene/HGNC:3285#orthology", "database": "AGR" }, { "id": "MGI:95304", "url": "https://alliancegenome.org/gene/MGI:95304#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-060629-1", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-060629-1#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "ribosomal small subunit binding", "id": "GO:0043024", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043024", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IMF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IMF6" } ], "pmid": "" }, { "name": "translation initiation factor activity", "id": "GO:0003743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003743", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IMF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IMF6" } ], "pmid": "" }, { "name": "RNA strand-exchange activity", "id": "GO:0034057", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034057", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IMF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IMF6" } ], "pmid": "" }, { "name": "RNA strand annealing activity", "id": "GO:0033592", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033592", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IMF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IMF6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "eukaryotic translation initiation factor 4F complex assembly", "id": "GO:0097010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097010", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IMF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IMF6" } ], "pmid": "" }, { "name": "formation of translation preinitiation complex", "id": "GO:0001731", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001731", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IMF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IMF6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 190, "end_pos": 192, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.agr", "label": "AGR Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 190, "end_pos": 192 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }