{ "uniprot_canonical_ac": "A0A0R4ILA2-1", "uniprot_ac": "A0A0R4ILA2", "uniprot_id": "A0A0R4ILA2_DANRE", "mass": { "chemical_mass": 89734.0, "monoisotopic_mass": 89734.0 }, "refseq": { "ac": "NP_001184090", "name": "neurotrophic tyrosine kinase, receptor, type 2b precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001184090" }, "gene_names": [ { "name": "ntrk2b", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ILA2", "id": "A0A0R4ILA2" }, { "name": "ntrk2b", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001184090", "id": "NP_001184090" }, { "name": "si:ch211-220b11.1; si:ch73-270f14.4; trkB2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001184090", "id": "NP_001184090" }, { "name": "si:ch211-220b11.1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ILA2", "id": "A0A0R4ILA2" }, { "name": "si:ch73-270f14.4", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ILA2", "id": "A0A0R4ILA2" }, { "name": "trkB2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ILA2", "id": "A0A0R4ILA2" } ], "protein_names": [ { "name": "Tyrosine-protein kinase receptor", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ILA2/entry#names_and_taxonomy", "id": "A0A0R4ILA2" }, { "name": "2.7.10.1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ILA2/entry#names_and_taxonomy", "id": "A0A0R4ILA2" }, { "name": "neurotrophic tyrosine kinase, receptor, type 2b precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001184090", "id": "NP_001184090" }, { "name": "neurotrophic tyrosine kinase, receptor, type 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001184090", "id": "NP_001184090" } ], "function": [ { "annotation": "##Evidence-Data-START## Transcript exon combination :: SRR32588719.4822944.1, SRR32588729.8339385.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476729, SAMEA4476730 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1. On Jun 25, 2025 this sequence version replaced NP_001184090.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.", "evidence": [ { "database": "RefSeq", "id": "NP_001184090", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001184090" } ] }, { "annotation": "The present results demonstrate that there is a parallel time-related decline in the expression of BDNF and TrkB in zebrafish.", "evidence": [ { "database": "RefSeq", "id": "NP_001184090", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001184090" }, { "database": "PubMed", "id": "20162349", "url": "https://glygen.org/publication/PubMed/20162349" } ] } ], "disease": [ { "disease_id": "DOID:0050156", "recommended_name": { "id": "DOID:0050156", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050156", "name": "idiopathic pulmonary fibrosis", "description": "A pulmonary fibrosis that is characterized by scarring of the lung characterized by stiffness in the lungs and makes it difficult to breathe." }, "synonyms": [ { "id": "DOID:0050156", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050156", "name": "FIBROCYSTIC PULMONARY DYSPLASIA", "description": "" }, { "id": "DOID:0050156", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050156", "name": "IDIOPATHIC PULMONARY FIBROSIS, FAMILIAL", "description": "" }, { "id": "DOID:0050156", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050156", "name": "cryptogenic fibrosing alveolitis", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "0050156", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050156" } ] }, { "disease_id": "DOID:0050741", "recommended_name": { "id": "DOID:0050741", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050741", "name": "alcohol dependence", "description": "A substance dependence that is characterized by tolerance, withdrawal symptoms, increasing use, persistent desire to decrease consumption, time spent obtaining or recovering from alcohol caused by a physical and psychological dependence on alcohol." }, "synonyms": [ { "id": "DOID:0050741", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050741", "name": "alcoholism", "description": "" }, { "id": "MONDO:0007079", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007079", "name": "alcohol dependence", "description": "Physical and psychological dependence on alcohol." }, { "id": "MONDO:0007079", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007079", "name": "alcohol dependence", "description": "" }, { "id": "MONDO:0007079", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007079", "name": "alcoholism", "description": "" }, { "id": "MONDO:0007079", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007079", "name": "aerodigestive tract cancer, squamous cell, alcohol-related, protection against", "description": "" }, { "id": "MONDO:0007079", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007079", "name": "alcohol dependence, protection against", "description": "" }, { "id": "MONDO:0007079", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007079", "name": "alcohol dependence, susceptibility to", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "0050741", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050741" } ] }, { "disease_id": "DOID:0050742", "recommended_name": { "id": "DOID:0050742", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050742", "name": "nicotine dependence", "description": "A substance dependence that is characterized by a physical dependence on nicotine." }, "synonyms": [ { "id": "DOID:0050742", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050742", "name": "tobacco use disorder", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "0050742", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050742" } ] }, { "disease_id": "DOID:0080285", "recommended_name": { "id": "DOID:0080285", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080285", "name": "developmental and epileptic encephalopathy 58", "description": "A developmental and epileptic encephalopathy characterized by onset in the first days or months of life of infantile spasms and refractory seizures, global developmental delay, and impaired intellectual development that has_material_basis_in heterozygous mutation in the NTRK2 gene on chromosome 9q21." }, "synonyms": [ { "id": "DOID:0080285", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080285", "name": "early infantile epileptic encephalopathy 58", "description": "" }, { "id": "DOID:0080285", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080285", "name": "DEE58", "description": "" }, { "id": "MONDO:0033367", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0033367", "name": "developmental and epileptic encephalopathy, 58", "description": "" }, { "id": "MONDO:0033367", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0033367", "name": "DEE58", "description": "" }, { "id": "MONDO:0033367", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0033367", "name": "EIEE58", "description": "" }, { "id": "MONDO:0033367", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0033367", "name": "developmental and epileptic encephalopathy 58", "description": "" }, { "id": "MONDO:0033367", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0033367", "name": "epileptic encephalopathy, early infantile, 58", "description": "" }, { "id": "MONDO:0033367", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0033367", "name": "infantile epileptic encephalopathy 58", "description": "" }, { "id": "MIM:617830", "resource": "MIM", "url": "https://www.omim.org/entry/617830", "name": "Developmental and epileptic encephalopathy 58", "description": "Developmental and epileptic encephalopathy 58" } ], "unlinked_id_list": [], "evidence": [ { "id": "0080285", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080285" } ] }, { "disease_id": "DOID:10652", "recommended_name": { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimer's disease", "description": "A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid." }, "synonyms": [ { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimer disease", "description": "" }, { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimers dementia", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "10652", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10652" } ] }, { "disease_id": "DOID:11981", "recommended_name": { "id": "DOID:11981", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11981", "name": "morbid obesity", "description": "" }, "synonyms": [ { "id": "DOID:11981", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11981", "name": "Severe obesity", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "11981", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:11981" } ] }, { "disease_id": "DOID:12849", "recommended_name": { "id": "DOID:12849", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12849", "name": "autistic disorder", "description": "An autism spectrum disorder that is characterized by symptoms across all three symptom domains (communication, social, restricted repetitive interests and behaviors), delayed language development, and symptom onset prior to age 3 years." }, "synonyms": [ { "id": "DOID:12849", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12849", "name": "Kanner's syndrome", "description": "" }, { "id": "DOID:12849", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12849", "name": "autism", "description": "" }, { "id": "DOID:12849", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12849", "name": "autistic disorder of childhood onset", "description": "" }, { "id": "DOID:12849", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12849", "name": "childhood autism", "description": "" }, { "id": "DOID:12849", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12849", "name": "infantile autism", "description": "" }, { "id": "MONDO:0005260", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005260", "name": "autism", "description": "Persistent deficits in social interaction and communication and interaction as well as a markedly restricted repertoire of activity and interest as well as repetitive patterns of behavior." }, { "id": "MONDO:0005260", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005260", "name": "autism spectrum disorder", "description": "" }, { "id": "MONDO:0005260", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005260", "name": "Kanner's syndrome", "description": "" }, { "id": "MONDO:0005260", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005260", "name": "autism", "description": "" }, { "id": "MONDO:0005260", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005260", "name": "autism (disease)", "description": "" }, { "id": "MONDO:0005260", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005260", "name": "autistic disorder of childhood onset", "description": "" }, { "id": "MONDO:0005260", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005260", "name": "childhood autism", "description": "" }, { "id": "MONDO:0005260", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005260", "name": "infantile autism", "description": "" }, { "id": "MONDO:0005260", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005260", "name": "autism, susceptiblity to", "description": "" }, { "id": "MONDO:0005260", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005260", "name": "autistic disorder", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "12849", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:12849" } ] }, { "disease_id": "DOID:1470", "recommended_name": { "id": "DOID:1470", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1470", "name": "major depressive disorder", "description": "A depressive disorder that is characterized by at least two weeks of loss of interest or pleasure in normally enjoyable activities or depressed mood along with additional cognitive or somatic impairments such as appetite or weight changes, sleep difficulties, psychomotor agitation or retardation, fatigue or loss of energy, diminished ability to think or concentrate, feelings of worthlessness or excessive guilt, and suicidality." }, "synonyms": [ { "id": "DOID:1470", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1470", "name": "clinical depression", "description": "" }, { "id": "DOID:1470", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1470", "name": "recurrent major depression", "description": "" }, { "id": "DOID:1470", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1470", "name": "single major depressive episode", "description": "" }, { "id": "DOID:1470", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1470", "name": "unipolar depression", "description": "" }, { "id": "DOID:1470", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1470", "name": "major depression", "description": "" }, { "id": "MONDO:0012100", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012100", "name": "major depressive disorder 2", "description": "" }, { "id": "MONDO:0012100", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012100", "name": "MDD2", "description": "" }, { "id": "MONDO:0012100", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012100", "name": "major depressive disorder 2", "description": "" }, { "id": "MONDO:0012100", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012100", "name": "major depressive disorder type 2", "description": "" }, { "id": "MONDO:0012100", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012100", "name": "unipolar depression 2", "description": "" }, { "id": "MONDO:0012050", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012050", "name": "major depressive disorder 1", "description": "" }, { "id": "MONDO:0012050", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012050", "name": "MDD1", "description": "" }, { "id": "MONDO:0012050", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012050", "name": "major depressive disorder 1", "description": "" }, { "id": "MONDO:0012050", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012050", "name": "major depressive disorder type 1", "description": "" }, { "id": "MONDO:0012050", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012050", "name": "unipolar depression 1", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "1470", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1470" } ] }, { "disease_id": "DOID:3312", "recommended_name": { "id": "DOID:3312", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3312", "name": "bipolar disorder", "description": "A mood disorder that involves alternating periods of mania and depression." }, "synonyms": [ { "id": "DOID:3312", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3312", "name": "Manic Bipolar Affective disorder", "description": "" }, { "id": "DOID:3312", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3312", "name": "Manic Depressive disorder", "description": "" }, { "id": "DOID:3312", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3312", "name": "Manic bipolar I disorder", "description": "" }, { "id": "DOID:3312", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3312", "name": "bipolar depression", "description": "" }, { "id": "DOID:3312", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3312", "name": "bipolar disorder manic phase", "description": "" }, { "id": "DOID:3312", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3312", "name": "manic depression", "description": "" }, { "id": "DOID:3312", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3312", "name": "manic disorder", "description": "" }, { "id": "DOID:3312", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3312", "name": "mixed bipolar disorder", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "3312", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3312" } ] }, { "disease_id": "DOID:3526", "recommended_name": { "id": "DOID:3526", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3526", "name": "cerebral infarction", "description": "A cerebrovascular disease that is characterized by an area of necrotic tissue in the brain resulting from a blockage or narrowing in the arteries supplying blood and oxygen to the brain." }, "synonyms": [ { "id": "DOID:3526", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3526", "name": "CVA - Cerebral infarction", "description": "" }, { "id": "DOID:3526", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3526", "name": "Cerebral infarct", "description": "" }, { "id": "MONDO:0020671", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0020671", "name": "obsolete susceptibility to ischemic stroke", "description": "" }, { "id": "MONDO:0020671", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0020671", "name": "cerebral infarction, susceptibility to", "description": "" }, { "id": "MONDO:0020671", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0020671", "name": "ischemic stroke, susceptibility to", "description": "" }, { "id": "MONDO:0020671", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0020671", "name": "stroke, ischemic, susceptibility to", "description": "" }, { "id": "MONDO:0020671", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0020671", "name": "stroke, susceptibility to", "description": "" }, { "id": "MONDO:0020671", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0020671", "name": "cerebral infarction", "description": "" }, { "id": "MONDO:0020671", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0020671", "name": "cerebrovascular accident", "description": "" }, { "id": "MONDO:0020671", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0020671", "name": "stroke, ischemic", "description": "" }, { "id": "MIM:601367", "resource": "MIM", "url": "https://www.omim.org/entry/601367", "name": "Ischemic stroke", "description": "Ischemic stroke" } ], "unlinked_id_list": [], "evidence": [ { "id": "3526", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3526" } ] }, { "disease_id": "DOID:5419", "recommended_name": { "id": "DOID:5419", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5419", "name": "schizophrenia", "description": "A psychotic disorder that is characterized by a disintegration of thought processes and of emotional responsiveness." }, "synonyms": [ { "id": "DOID:5419", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5419", "name": "schizophrenia-1", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizophrenia", "description": "A major psychotic disorder characterized by abnormalities in the perception or expression of reality. It affects the cognitive and psychomotor functions. Common clinical signs and symptoms include delusions, hallucinations, disorganized thinking, and retreat from reality." }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizophrenia 12", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizophrenia", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizophrenia (disease)", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizophrenia-1", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "SCZD", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizoaffective disorder", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizophrenia with or without an affective disorder", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizophrenia, susceptibility to", "description": "" }, { "id": "MIM:181500", "resource": "MIM", "url": "https://www.omim.org/entry/181500", "name": "Schizophrenia", "description": "Schizophrenia" } ], "unlinked_id_list": [], "evidence": [ { "id": "5419", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5419" } ] }, { "disease_id": "DOID:9976", "recommended_name": { "id": "DOID:9976", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9976", "name": "heroin dependence", "description": "An opiate dependence that involves the continued use of heroin despite problems related to use of the substance." }, "synonyms": [], "unlinked_id_list": [], "evidence": [ { "id": "9976", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9976" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Danio rerio", "taxid": 7955, "evidence": [ { "database": "UniProtKB", "id": "A0A0R4ILA2", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ILA2" } ], "common_name": "Zebrafish", "glygen_name": "Zebrafish", "reference_species": "Danio rerio [7955]" } ], "gene": [ { "name": "ntrk2b", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ILA2", "locus": {} } ], "crossref": [ { "id": "ZFIN:ZDB-GENE-010126-2", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-010126-2", "database": "AGR", "categories": [ "Protein Classification" ] }, { "id": "ENSDARG00000098511", "url": "https://bgee.org/?page=gene&gene_id=ENSDARG00000098511", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05093", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05093", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd05855", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05855", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "570240", "url": "https://www.ncbi.nlm.nih.gov/gene/570240", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001245", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001245", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008266", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008266", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017441", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020635", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020635", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020777", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020777", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050122", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050122", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dre:570240", "url": "https://www.genome.jp/dbget-bin/www_bget?dre:570240", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A0R4ILA2", "url": "https://www.orthodb.org/?gene=A0A0R4ILA2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24416", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24416", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24416:SF575", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24416:SF575", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07679", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07679", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF07714", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF07714", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13855", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "NP_001184090", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001184090", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "10596", "url": "https://www.rhea-db.org/rhea/10596", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A0R4ILA2", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ILA2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0R4ILA2-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ILA2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "ZDB-GENE-010126-2", "url": "https://zfin.org/ZDB-GENE-010126-2", "database": "ZFIN", "categories": [ "Protein", "Organism-specific" ] } ], "sequence": { "sequence": "MTAGVRGMACWGLCGFLFGLLRISSACPVSCFCNASRISCIDQEPGIEDFPVLMPESDMENITDIYISNQKRLFTINEDHMKFYSNLRNLTVTNTHLTYVSTMAFFNNSKLQYLNLGDNNLSTLSWMAMRNSNVSTLLLSGNPLQCACENIWIKLWLDDSERDVLQCLQEGGKAKTLSRLTLPLCEHPRVEVFPTDVSQMAGSDATVICNASGSPTPELTWTLNSSEHPPLSTSHEISKMDLQSVLTLNGLSPNDNGRKLICSAENIVGQIEATVMLNISFPPTVLELYLPERSQDWCIPFVVTGNPRPDLHWYHEGKPLEEQEYIRTEIHDITNTEYHGCLKLDTPTHIHNGIYTLVASNEFGEDRGNVTAHFMRIPDVDHSGIEGVFYYDTTVSPDIPPLEDRVAVYIVVGIAGVALTGCILMLVFLKYGRSSKFGMKGSSSVISNDDDSASPLHHVSNGNNTPSSSEMGPDAVIIGMTKIPVIENPQYFRNPGSMLKSDTLVQHIKRHNILLKRELGEGAFGKVFLAECYNLSPDQEKILVAVKTLKEASESGRADFHREAELLTNLQHEHIVKFYGVCVESDPLIMVFEYMKHGDLNKFLRAHGPDAVLMADGQQSLLVELTQPQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRRFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPKEVYDLMLGCWQREPYMRLNIKEIHNLLQSLAKASPVYLDILG", "length": 799, "header": "tr|A0A0R4ILA2-1|A0A0R4ILA2_DANRE Isoform 1 of Tyrosine-protein kinase receptor OS=Danio rerio OX=7955 GN=ntrk2b PE=3 SV=1 CANONICAL=A0A0R4ILA2-1" }, "isoforms": [ { "isoform_ac": "A0A0R4ILA2-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ILA2/entry#A0A0R4ILA2-1", "sequence": { "sequence": "MTAGVRGMACWGLCGFLFGLLRISSACPVSCFCNASRISCIDQEPGIEDFPVLMPESDMENITDIYISNQKRLFTINEDHMKFYSNLRNLTVTNTHLTYVSTMAFFNNSKLQYLNLGDNNLSTLSWMAMRNSNVSTLLLSGNPLQCACENIWIKLWLDDSERDVLQCLQEGGKAKTLSRLTLPLCEHPRVEVFPTDVSQMAGSDATVICNASGSPTPELTWTLNSSEHPPLSTSHEISKMDLQSVLTLNGLSPNDNGRKLICSAENIVGQIEATVMLNISFPPTVLELYLPERSQDWCIPFVVTGNPRPDLHWYHEGKPLEEQEYIRTEIHDITNTEYHGCLKLDTPTHIHNGIYTLVASNEFGEDRGNVTAHFMRIPDVDHSGIEGVFYYDTTVSPDIPPLEDRVAVYIVVGIAGVALTGCILMLVFLKYGRSSKFGMKGSSSVISNDDDSASPLHHVSNGNNTPSSSEMGPDAVIIGMTKIPVIENPQYFRNPGSMLKSDTLVQHIKRHNILLKRELGEGAFGKVFLAECYNLSPDQEKILVAVKTLKEASESGRADFHREAELLTNLQHEHIVKFYGVCVESDPLIMVFEYMKHGDLNKFLRAHGPDAVLMADGQQSLLVELTQPQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRRFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPKEVYDLMLGCWQREPYMRLNIKEIHNLLQSLAKASPVYLDILG", "length": 799, "header": "tr|A0A0R4ILA2-1|A0A0R4ILA2_DANRE Isoform 1 of Tyrosine-protein kinase receptor OS=Danio rerio OX=7955 GN=ntrk2b PE=3 SV=1 CANONICAL=A0A0R4ILA2-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "start_pos": 216, "start_aa": "Thr", "end_pos": 216, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr216", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "00000000000000001000.00000000001000.0.xxxxx" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "The zebrafish gene map defines ancestral vertebrate chromosomes.", "journal": "Genome Res.", "date": "2005", "authors": "Woods Ian G, Wilson Catherine, Friedlander Brian, Chang Patricia, Reyes Daengnoy K, Nix Rebecca, Kelly Peter D, Chu Felicia, Postlethwait John H, Talbot William S", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4ILA2", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ILA2" } ], "reference": [ { "type": "PubMed", "id": "16109975", "url": "https://glygen.org/publication/PubMed/16109975" } ] }, { "title": "Characterization of retinoid-X receptor genes rxra, rxrba, rxrbb and rxrg during zebrafish development.", "journal": "Gene Expr. Patterns", "date": "2006", "authors": "Tallafuss Alexandra, Hale Laura A, Yan Yi-Lin, Dudley Leana, Eisen Judith S, Postlethwait John H", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4ILA2", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ILA2" } ], "reference": [ { "type": "PubMed", "id": "16448862", "url": "https://glygen.org/publication/PubMed/16448862" } ] }, { "title": "Assignment of zebrafish genetic linkage groups to chromosomes.", "journal": "Cytogenet. Genome Res.", "date": "2006", "authors": "Phillips R B, Amores A, Morasch M R, Wilson C, Postlethwait J H", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4ILA2", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ILA2" } ], "reference": [ { "type": "PubMed", "id": "16825768", "url": "https://glygen.org/publication/PubMed/16825768" } ] }, { "title": "Expression of brain-derived neurotrophic factor and TrkB in the lateral line system of zebrafish during development.", "journal": "Cell. Mol. Neurobiol.", "date": "2010", "authors": "German\u00e0 A, Laur\u00e0 R, Montalbano G, Guerrera M C, Amato V, Zichichi R, Campo S, Ciriaco E, Vega J A", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4ILA2", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ILA2" }, { "database": "RefSeq", "id": "NP_001184090", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001184090" } ], "reference": [ { "type": "PubMed", "id": "20162349", "url": "https://glygen.org/publication/PubMed/20162349" } ] }, { "title": "The zebrafish reference genome sequence and its relationship to the human genome.", "journal": "Nature", "date": "2013", "authors": "Howe Kerstin, Clark Matthew D, Torroja Carlos F, Torrance James, Berthelot Camille, Muffato Matthieu, Collins John E, Humphray Sean, McLaren Karen, Matthews Lucy, McLaren Stuart, Sealy Ian, Caccamo Mario, Churcher Carol, Scott Carol, Barrett Jeffrey C, Koch Romke, Rauch Gerd-J\u00f6rg, White Simon, Chow William, Kilian Britt, Quintais Leonor T, Guerra-Assun\u00e7\u00e3o Jos\u00e9 A, Zhou Yi, Gu Yong, Yen Jennifer, Vogel Jan-Hinnerk, Eyre Tina, Redmond Seth, Banerjee Ruby, Chi Jianxiang, Fu Beiyuan, Langley Elizabeth, Maguire Sean F, Laird Gavin K, Lloyd David, Kenyon Emma, Donaldson Sarah, Sehra Harminder, Almeida-King Jeff, Loveland Jane, Trevanion Stephen, Jones Matt, Quail Mike, Willey Dave, Hunt Adrienne, Burton John, Sims Sarah, McLay Kirsten, Plumb Bob, Davis Joy, Clee Chris, Oliver Karen, Clark Richard, Riddle Clare, Elliot David, Eliott David, Threadgold Glen, Harden Glenn, Ware Darren, Begum Sharmin, Mortimore Beverley, Mortimer Beverly, Kerry Giselle, Heath Paul, Phillimore Benjamin, Tracey Alan, Corby Nicole, Dunn Matthew, Johnson Christopher, Wood Jonathan, Clark Susan, Pelan Sarah, Griffiths Guy, Smith Michelle, Glithero Rebecca, Howden Philip, Barker Nicholas, Lloyd Christine, Stevens Christopher, Harley Joanna, Holt Karen, Panagiotidis Georgios, Lovell Jamieson, Beasley Helen, Henderson Carl, Gordon Daria, Auger Katherine, Wright Deborah, Collins Joanna, Raisen Claire, Dyer Lauren, Leung Kenric, Robertson Lauren, Ambridge Kirsty, Leongamornlert Daniel, McGuire Sarah, Gilderthorp Ruth, Griffiths Coline, Manthravadi Deepa, Nichol Sarah, Barker Gary, Whitehead Siobhan, Kay Michael, Brown Jacqueline, Murnane Clare, Gray Emma, Humphries Matthew, Sycamore Neil, Barker Darren, Saunders David, Wallis Justene, Babbage Anne, Hammond Sian, Mashreghi-Mohammadi Maryam, Barr Lucy, Martin Sancha, Wray Paul, Ellington Andrew, Matthews Nicholas, Ellwood Matthew, Woodmansey Rebecca, Clark Graham, Cooper James D, Cooper James, Tromans Anthony, Grafham Darren, Skuce Carl, Pandian Richard, Andrews Robert, Harrison Elliot, Kimberley Andrew, Garnett Jane, Fosker Nigel, Hall Rebekah, Garner Patrick, Kelly Daniel, Bird Christine, Palmer Sophie, Gehring Ines, Berger Andrea, Dooley Christopher M, Ersan-\u00dcr\u00fcn Z\u00fcbeyde, Eser Cigdem, Geiger Horst, Geisler Maria, Karotki Lena, Kirn Anette, Konantz Judith, Konantz Martina, Oberl\u00e4nder Martina, Rudolph-Geiger Silke, Teucke Mathias, Lanz Christa, Raddatz G\u00fcnter, Osoegawa Kazutoyo, Zhu Baoli, Rapp Amanda, Widaa Sara, Langford Cordelia, Yang Fengtang, Schuster Stephan C, Carter Nigel P, Harrow Jennifer, Ning Zemin, Herrero Javier, Searle Steve M J, Enright Anton, Geisler Robert, Plasterk Ronald H A, Lee Charles, Westerfield Monte, de Jong Pieter J, Zon Leonard I, Postlethwait John H, N\u00fcsslein-Volhard Christiane, Hubbard Tim J P, Roest Crollius Hugues, Rogers Jane, Stemple Derek L", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4ILA2", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ILA2" } ], "reference": [ { "type": "PubMed", "id": "23594743", "url": "https://glygen.org/publication/PubMed/23594743" } ] }, { "title": "The Ameliorative Effects of Isorhynchophylline on Morphine Dependence Are Mediated Through the Microbiota-Gut-Brain Axis.", "journal": "Front. Pharmacol.", "date": "2021", "authors": "Chen Zhu, Zhijie Chen, Yuting Zhou, Chan Li, Shilin Xiao, Qichun Zhou, Jinying Ou, Jing Li, Chaohua Luo, Zhixian Mo", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4ILA2", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ILA2" } ], "reference": [ { "type": "PubMed", "id": "34168553", "url": "https://glygen.org/publication/PubMed/34168553" } ] }, { "title": "Increased locomotor activity via regulation of GABAergic signalling in foxp2 mutant zebrafish-implications for neurodevelopmental disorders.", "journal": "Transl. Psychiatry", "date": "2021", "authors": "L\u00fcffe Teresa M, D'Orazio Andrea, Bauer Moritz, Gioga Zoi, Schoeffler Victoria, Lesch Klaus-Peter, Romanos Marcel, Drepper Carsten, Lillesaar Christina", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4ILA2", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ILA2" } ], "reference": [ { "type": "PubMed", "id": "34650032", "url": "https://glygen.org/publication/PubMed/34650032" } ] }, { "title": "Brain Proteome and Behavioural Analysis in Wild Type, BDNF(+/-) and BDNF(-/-) Adult Zebrafish (Danio rerio) Exposed to Two Different Temperatures.", "journal": "Int. J. Mol. Sci.", "date": "2022", "authors": "Maffioli Elisa, Angiulli Elisa, Nonnis Simona, Grassi Scalvini Francesca, Negri Armando, Tedeschi Gabriella, Arisi Ivan, Frabetti Flavia, D'Aniello Salvatore, Alleva Enrico, Cioni Carla, Toni Mattia", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4ILA2", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ILA2" } ], "reference": [ { "type": "PubMed", "id": "35628418", "url": "https://glygen.org/publication/PubMed/35628418" } ] }, { "title": "Analysis of the Expression of Neurotrophins and Their Receptors in Adult Zebrafish Kidney.", "journal": "Vet Sci 5 (2)", "date": "2022", "authors": "Cacialli Pietro, Lucini Carla", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4ILA2", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ILA2" } ], "reference": [ { "type": "PubMed", "id": "35737348", "url": "https://glygen.org/publication/PubMed/35737348" } ] }, { "title": "Myostatin is a negative regulator of adult neurogenesis after spinal cord injury in zebrafish.", "journal": "Cell Rep.", "date": "2022", "authors": "Saraswathy Vishnu Muraleedharan, Zhou Lili, McAdow Anthony R, Burris Brooke, Dogra Deepika, Reischauer Sven, Mokalled Mayssa H", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4ILA2", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ILA2" } ], "reference": [ { "type": "PubMed", "id": "36417881", "url": "https://glygen.org/publication/PubMed/36417881" } ] }, { "title": "Five Trk receptors in the zebrafish.", "journal": "Dev. Biol.", "date": "1995", "authors": "Martin S C, Marazzi G, Sandell J H, Heinrich G", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4ILA2", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ILA2" } ], "reference": [ { "type": "PubMed", "id": "7781913", "url": "https://glygen.org/publication/PubMed/7781913" } ] } ], "pathway": [ { "id": "dre:570240", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?dre:570240", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "P15209-1", "protein_name": "BDNF/NT-3 growth factors receptor", "gene_name": "Ntrk2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSPWLKWHGPAMARLWGLCLLVLGFWRASLACPTSCKCSSARIWCTEPSPGIVAFPRLEPNSVDPENITEILIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAYKAFLKNSNLRHINFTRNKLTSLSRRHFRHLDLSDLILTGNPFTCSCDIMWLKTLQETKSSPDTQDLYCLNESSKNMPLANLQIPNCGLPSARLAAPNLTVEEGKSVTLSCSVGGDPLPTLYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVRGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLMAKNEYGKDERQISAHFMGRPGVDYETNPNYPEVLYEDWTTPTDIGDTTNKSNEIPSTDVADQSNREHLSVYAVVVIASVVGFCLLVMLLLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHTRKNIKSIHTLLQNLAKASPVYLDILG", "length": 821 }, "evidence": [ { "id": "HGNC:8032", "url": "https://alliancegenome.org/gene/HGNC:8032#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q16620-1", "protein_name": "BDNF/NT-3 growth factors receptor", "gene_name": "NTRK2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG", "length": 822 }, "evidence": [ { "id": "HGNC:8032", "url": "https://alliancegenome.org/gene/HGNC:8032#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-010126-2", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-010126-2#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q63604-1", "protein_name": "BDNF/NT-3 growth factors receptor", "gene_name": "Ntrk2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSPWPRWHGPAMARLWGLCLLVLGFWRASLACPMSCKCSTTRIWCTEPSPGIVAFPRLEPNSIDPENITEILIANQKRLEIINEDDVEAYVGLKNLTIVDSGLKFVAYKAFLKNGNLRHINFTRNKLTSLSRRHFRHLDLSDLILTGNPFTCSCDIMWLKTLQETKSSPDTQDLYCLNESSKNTPLANLQIPNCGLPSARLAAPNLTVEEGKSVTISCSVGGDPLPTLYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVRGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLMAKNEYGKDERQISAHFMGRPGVDYETNPNYPEVLYEDWTTPTDIGDTTNKSNEIPSTDVADQTNREHLSVYAVVVIASVVGFCLLVMLLLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHTRKNIKNIHTLLQNLAKASPVYLDILG", "length": 821 }, "evidence": [ { "id": "HGNC:8032", "url": "https://alliancegenome.org/gene/HGNC:8032#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "cellular response to brain-derived neurotrophic factor stimulus", "id": "GO:1990416", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990416", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4ILA2", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ILA2" } ], "pmid": "" }, { "name": "cell surface receptor protein tyrosine kinase signaling pathway", "id": "GO:0007169", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007169", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4ILA2", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ILA2" } ], "pmid": "" }, { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4ILA2", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ILA2" } ], "pmid": "" }, { "name": "positive regulation of neuron projection development", "id": "GO:0010976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010976", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4ILA2", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ILA2" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4ILA2", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ILA2" } ], "pmid": "" }, { "name": "positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "id": "GO:0051897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051897", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4ILA2", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ILA2" } ], "pmid": "" }, { "name": "lateral line development", "id": "GO:0048882", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048882", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4ILA2", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ILA2" } ], "pmid": "" }, { "name": "neuromast primordium migration", "id": "GO:0048883", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048883", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4ILA2", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ILA2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "brain-derived neurotrophic factor receptor activity", "id": "GO:0060175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060175", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4ILA2", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ILA2" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4ILA2", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ILA2" } ], "pmid": "" }, { "name": "brain-derived neurotrophic factor binding", "id": "GO:0048403", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048403", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4ILA2", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ILA2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4ILA2", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ILA2" } ], "pmid": "" }, { "name": "axon", "id": "GO:0030424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4ILA2", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ILA2" } ], "pmid": "" }, { "name": "receptor complex", "id": "GO:0043235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043235", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4ILA2", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ILA2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 107, "end_pos": 109, "annotation": "n_glycosylation_sequon" }, { "start_pos": 120, "end_pos": 122, "annotation": "n_glycosylation_sequon" }, { "start_pos": 133, "end_pos": 135, "annotation": "n_glycosylation_sequon" }, { "start_pos": 210, "end_pos": 212, "annotation": "n_glycosylation_sequon" }, { "start_pos": 224, "end_pos": 226, "annotation": "n_glycosylation_sequon" }, { "start_pos": 278, "end_pos": 280, "annotation": "n_glycosylation_sequon" }, { "start_pos": 34, "end_pos": 36, "annotation": "n_glycosylation_sequon" }, { "start_pos": 369, "end_pos": 371, "annotation": "n_glycosylation_sequon" }, { "start_pos": 463, "end_pos": 465, "annotation": "n_glycosylation_sequon" }, { "start_pos": 534, "end_pos": 536, "annotation": "n_glycosylation_sequon" }, { "start_pos": 61, "end_pos": 63, "annotation": "n_glycosylation_sequon" }, { "start_pos": 89, "end_pos": 91, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10596", "name": "", "equation": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0AB32T7U3-1", "B1NA68-1", "A0A2R8Q5G9-1", "A0A8M1RLP2-1", "A0A8M9PC12-1", "A1A5H8-1", "A2BIL7-1", "A0A8M1N4R3-1", "A0A8M9QKL5-1", "A0A8N7UZS2-1", "A8E7C6-1", "A0A2R8Q7T0-1", "A0A8M3AR79-1", "Q9I8X3-1", "Q1JPZ3-1", "A0A8M3ASR9-1", "Q4V947-1", "A0A8M1RHB8-1", "Q90Z00-1", "Q8JG38-1", "A1L1U2-1", "A0A8M1QKN2-1", "A0A8M2B201-1", "F1QVU0-1", "F1RDG9-1", "F8W3R9-1", "O12990-1", "O13146-1", "O13147-1", "O13148-1", "O73791-1", "O73792-1", "O73875-1", "O73878-1", "Q4V958-1", "Q4VSN1-1", "Q5GIT4-1", "Q5MD89-1", "B3DKP1-1", "F1QWX8-1", "F6P1M3-1", "Q1LVG4-1", "Q5EBY4-1", "Q5J1R9-1", "A0A8M1NUM7-1", "A0A8M2BIL6-1", "A0A8M2BDJ7-1", "Q9YI66-1", "Q6EWH2-1", "Q8AXB3-1", "Q8AYG3-1", "Q8JFR5-1", "Q90413-1", "Q9DE49-1", "Q9DGE0-1", "Q9I8N6-1", "A0A8M2BD22-1", "A0A8N7UW23-1", "A0A8M2B3P5-1", "A0A8M9Q7Y5-1", "A0A8M9QDR9-1", "A0A8M9QI71-1", "B0V237-1", "B8A5K6-1", "Q7SZF7-1", "A0A8M2B533-1", "A0A0R4ITS5-1", "A0A0R4IYB8-1", "A0A0R4J755-1", "E7F3X9-1", "Q1LX51-1", "Q1LYE1-1", "Q6DHU8-1", "Q503P3-1", "F1QKJ0-1", "Q1LY62-1", "Q7T2V4-1", "A0AB32U1Z7-1", "A0A8M2B5G2-1", "D6RRB7-1", "A0A8M3AQW8-1", "E7FFT8-1", "A0A8M9QMM1-1", "A9JRD0-1", "A0A8M6YUU4-1", "A0A8M6Z131-1", "A2VCY1-1", "C0RW38-1", "A0A8N7TED1-1", "A0A8M9Q613-1", "A0A8M9PQU9-1", "A0JMN4-1", "E7FEW6-1", "F1QWE3-1", "Q1RLY5-1", "F8W2F9-1", "Q08BY6-1", "Q7T2P8-1", "A0AB13A7B9-1", "X1WHM4-1", "A0A8M6Z4R0-1", "A0A8M6Z1G5-1", "A0A8M1RTJ4-1", "A0A8N7T808-1", "A0A8N7T8N4-1", "E7F063-1", "A0A0R4ILA2-1", "A0A8M1PBN6-1", "A0A8M3AX73-1", "A0A8N7UZ77-1", "A0AB32TBA1-1", "A0A8M1NFV1-1", "A0A8M1PBC4-1", "A0AB40EDC8-1", "A0AB13A3P4-1", "A0A8M1QKD8-1", "A0A8M2B3B8-1", "A2CEJ3-1", "Q5VSJ4-1", "A0A8M3B5I9-1", "Q90ZN9-1", "E7F2W4-1", "E7F533-1", "F1QJD4-1", "F6P3V1-1", "Q6NZS1-1", "A0A8M9PSM0-1", "Q1L8U4-1", "A0A8M6Z303-1", "C4B4T7-1", "A0A8M3BDV7-1", "A0A8M1P6Z5-1", "A0A8M6Z1S2-1", "A0A8M1NB07-1" ], "evidence": [ { "id": "10596", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10596" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A0R4ILA2", "gene_name": "ntrk2b", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A0R4ILA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ILA2" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A0R4ILA2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ILA2" } ] } ] }, { "uniprot_ac": "A0A0R4ITS5", "gene_name": "dyrk2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A0R4ITS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ITS5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A0R4ITS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ITS5" } ] } ] }, { "uniprot_ac": "A0A0R4IYB8", "gene_name": "abl2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A0R4IYB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IYB8" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A0R4IYB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IYB8" } ] } ] }, { "uniprot_ac": "A0A0R4J755", "gene_name": "hck", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A0R4J755", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0R4J755" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A0R4J755", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0R4J755" } ] } ] }, { "uniprot_ac": "A0A2R8Q5G9", "gene_name": "dyrk4", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A2R8Q5G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A2R8Q5G9" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A2R8Q5G9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A2R8Q5G9" } ] } ] }, { "uniprot_ac": "A0A2R8Q7T0", "gene_name": "fes", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A2R8Q7T0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A2R8Q7T0" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A2R8Q7T0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A2R8Q7T0" } ] } ] }, { "uniprot_ac": "A0A8M1N4R3", "gene_name": "erbb3b", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A8M1N4R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M1N4R3" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A8M1N4R3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M1N4R3" } ] } ] }, { "uniprot_ac": "A0A8M1NB07", "gene_name": "mtor", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A8M1NB07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M1NB07" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8M1NB07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M1NB07" } ] } ] }, { "uniprot_ac": "A0A8M1NFV1", "gene_name": "tec", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A8M1NFV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M1NFV1" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A8M1NFV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M1NFV1" } ] } ] }, { "uniprot_ac": "A0A8M1NUM7", "gene_name": "fgfr1b", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A8M1NUM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M1NUM7" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A8M1NUM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M1NUM7" } ] } ] }, { "uniprot_ac": "A0A8M1P6Z5", "gene_name": "ephb3a", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A8M1P6Z5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M1P6Z5" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A8M1P6Z5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M1P6Z5" } ] } ] }, { "uniprot_ac": "A0A8M1PBC4", "gene_name": "itk", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A8M1PBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M1PBC4" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A8M1PBC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M1PBC4" } ] } ] }, { "uniprot_ac": "A0A8M1PBN6", "gene_name": "igf1rb", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A8M1PBN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M1PBN6" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A8M1PBN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M1PBN6" } ] } ] }, { "uniprot_ac": "A0A8M1QKD8", "gene_name": "ephb2a", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A8M1QKD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M1QKD8" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A8M1QKD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M1QKD8" } ] } ] }, { "uniprot_ac": "A0A8M1QKN2", "gene_name": "flt3", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A8M1QKN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M1QKN2" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A8M1QKN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M1QKN2" } ] } ] }, { "uniprot_ac": "A0A8M1RHB8", "gene_name": "ntrk3b", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A8M1RHB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M1RHB8" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A8M1RHB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M1RHB8" } ] } ] }, { "uniprot_ac": "A0A8M1RLP2", "gene_name": "lyn", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A8M1RLP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M1RLP2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A8M1RLP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M1RLP2" } ] } ] }, { "uniprot_ac": "A0A8M1RTJ4", "gene_name": "txk", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A8M1RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M1RTJ4" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A8M1RTJ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M1RTJ4" } ] } ] }, { "uniprot_ac": "A0A8M2B201", "gene_name": "syk", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A8M2B201", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M2B201" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A8M2B201", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M2B201" } ] } ] }, { "uniprot_ac": "A0A8M2B3B8", "gene_name": "eif2ak3", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A8M2B3B8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M2B3B8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8M2B3B8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M2B3B8" } ] } ] }, { "uniprot_ac": "A0A8M2B3P5", "gene_name": "dyrk1ab", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A8M2B3P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M2B3P5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A8M2B3P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M2B3P5" } ] } ] }, { "uniprot_ac": "A0A8M2B533", "gene_name": "dyrk1b", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A8M2B533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M2B533" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A8M2B533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M2B533" } ] } ] }, { "uniprot_ac": "A0A8M2B5G2", "gene_name": "ptk2ba", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A8M2B5G2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M2B5G2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A8M2B5G2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M2B5G2" } ] } ] }, { "uniprot_ac": "A0A8M2BD22", "gene_name": "erbb3a", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A8M2BD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M2BD22" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A8M2BD22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M2BD22" } ] } ] }, { "uniprot_ac": "A0A8M2BDJ7", "gene_name": "mst1ra", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A8M2BDJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M2BDJ7" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A8M2BDJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M2BDJ7" } ] } ] }, { "uniprot_ac": "A0A8M2BIL6", "gene_name": "insra", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A8M2BIL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M2BIL6" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A8M2BIL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M2BIL6" } ] } ] }, { "uniprot_ac": "A0A8M3AQW8", "gene_name": "tyk2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A8M3AQW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M3AQW8" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A8M3AQW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M3AQW8" } ] } ] }, { "uniprot_ac": "A0A8M3AR79", "gene_name": "ros1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A8M3AR79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M3AR79" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A8M3AR79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M3AR79" } ] } ] }, { "uniprot_ac": "A0A8M3ASR9", "gene_name": "fer", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A8M3ASR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M3ASR9" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A8M3ASR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M3ASR9" } ] } ] }, { "uniprot_ac": "A0A8M3AX73", "gene_name": "csf1rb", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A8M3AX73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M3AX73" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A8M3AX73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M3AX73" } ] } ] }, { "uniprot_ac": "A0A8M3B5I9", "gene_name": "epha3", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A8M3B5I9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M3B5I9" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A8M3B5I9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M3B5I9" } ] } ] }, { "uniprot_ac": "A0A8M3BDV7", "gene_name": "epha8", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A8M3BDV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M3BDV7" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A8M3BDV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M3BDV7" } ] } ] }, { "uniprot_ac": "A0A8M6YUU4", "gene_name": "blk", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A8M6YUU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M6YUU4" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A8M6YUU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M6YUU4" } ] } ] }, { "uniprot_ac": "A0A8M6Z131", "gene_name": "ddr2b", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A8M6Z131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M6Z131" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A8M6Z131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M6Z131" } ] } ] }, { "uniprot_ac": "A0A8M6Z1G5", "gene_name": "axl", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A8M6Z1G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M6Z1G5" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A8M6Z1G5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M6Z1G5" } ] } ] }, { "uniprot_ac": "A0A8M6Z1S2", "gene_name": "pkdccb", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A8M6Z1S2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M6Z1S2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A8M6Z1S2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M6Z1S2" } ] } ] }, { "uniprot_ac": "A0A8M6Z303", "gene_name": "ephb1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A8M6Z303", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M6Z303" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A8M6Z303", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M6Z303" } ] } ] }, { "uniprot_ac": "A0A8M6Z4R0", "gene_name": "LOC101884366", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A8M6Z4R0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M6Z4R0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A8M6Z4R0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M6Z4R0" } ] } ] }, { "uniprot_ac": "A0A8M9PC12", "gene_name": "frk", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A8M9PC12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M9PC12" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A8M9PC12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M9PC12" } ] } ] }, { "uniprot_ac": "A0A8M9PQU9", "gene_name": "ddr2l", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A8M9PQU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M9PQU9" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A8M9PQU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M9PQU9" } ] } ] }, { "uniprot_ac": "A0A8M9PSM0", "gene_name": "LOC137487186", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A8M9PSM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M9PSM0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A8M9PSM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M9PSM0" } ] } ] }, { "uniprot_ac": "A0A8M9Q613", "gene_name": "tesk1a", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A8M9Q613", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M9Q613" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A8M9Q613", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M9Q613" } ] } ] }, { "uniprot_ac": "A0A8M9Q7Y5", "gene_name": "si:ch73-383l1.1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A8M9Q7Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M9Q7Y5" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A8M9Q7Y5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M9Q7Y5" } ] } ] }, { "uniprot_ac": "A0A8M9QDR9", "gene_name": "map2k2b", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A8M9QDR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M9QDR9" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "A0A8M9QDR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M9QDR9" } ] } ] }, { "uniprot_ac": "A0A8M9QI71", "gene_name": "mst1rb", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A8M9QI71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M9QI71" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A8M9QI71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M9QI71" } ] } ] }, { "uniprot_ac": "A0A8M9QKL5", "gene_name": "pdgfrb", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A8M9QKL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M9QKL5" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A8M9QKL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M9QKL5" } ] } ] 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"LOC571431", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A8N7T8N4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8N7T8N4" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A8N7T8N4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8N7T8N4" } ] } ] }, { "uniprot_ac": "A0A8N7TED1", "gene_name": "ptk6a", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A8N7TED1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8N7TED1" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A8N7TED1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8N7TED1" } ] } ] }, { "uniprot_ac": "A0A8N7UW23", "gene_name": "btk", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A8N7UW23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8N7UW23" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A8N7UW23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8N7UW23" } ] } ] }, { "uniprot_ac": "A0A8N7UZ77", "gene_name": "erbb4a", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A8N7UZ77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8N7UZ77" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A8N7UZ77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8N7UZ77" } ] } ] }, { "uniprot_ac": "A0A8N7UZS2", "gene_name": "igf1ra", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0A8N7UZS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8N7UZS2" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A8N7UZS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8N7UZS2" } ] } ] }, { "uniprot_ac": "A0AB13A3P4", "gene_name": "ntrk2a", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AB13A3P4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AB13A3P4" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0AB13A3P4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AB13A3P4" } ] } ] }, { "uniprot_ac": "A0AB13A7B9", "gene_name": "yrk", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AB13A7B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AB13A7B9" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AB13A7B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AB13A7B9" } ] } ] }, { "uniprot_ac": "A0AB32T7U3", "gene_name": "ptk2ab", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AB32T7U3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AB32T7U3" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0AB32T7U3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AB32T7U3" } ] } ] }, { "uniprot_ac": "A0AB32TBA1", "gene_name": "clk2b", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0AB32TBA1", "database": "UniProtKB", "url": 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"ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0AB40EDC8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0AB40EDC8" } ] } ] }, { "uniprot_ac": "A0JMN4", "gene_name": "csk", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A0JMN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JMN4" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0JMN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0JMN4" } ] } ] }, { "uniprot_ac": "A1A5H8", "gene_name": "yes1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A1A5H8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A1A5H8" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A1A5H8", "database": 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"ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2BIL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2BIL7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A2BIL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2BIL7" } ] } ] }, { "uniprot_ac": "A2CEJ3", "gene_name": "ephb2b", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2CEJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2CEJ3" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A2CEJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2CEJ3" } ] } ] }, { "uniprot_ac": "A2VCY1", "gene_name": "tesk2", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A2VCY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VCY1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A2VCY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2VCY1" } ] } ] }, { "uniprot_ac": "A8E7C6", "gene_name": "ret", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A8E7C6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A8E7C6" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A8E7C6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A8E7C6" } ] } ] }, { "uniprot_ac": "A9JRD0", "gene_name": "map2k5", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "A9JRD0", "database": "UniProtKB", "url": 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"evidence": [ { "id": "B1NA68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/B1NA68" } ] } ] }, { "uniprot_ac": "B3DKP1", "gene_name": "flt1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "B3DKP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/B3DKP1" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "B3DKP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/B3DKP1" } ] } ] }, { "uniprot_ac": "B8A5K6", "gene_name": "kitb", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "B8A5K6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/B8A5K6" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "B8A5K6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/B8A5K6" } ] } ] }, { "uniprot_ac": "C0RW38", "gene_name": "jak2b", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "C0RW38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/C0RW38" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "C0RW38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/C0RW38" } ] } ] }, { "uniprot_ac": "C4B4T7", "gene_name": "pkdcca", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "C4B4T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/C4B4T7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "C4B4T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/C4B4T7" } ] } ] }, { "uniprot_ac": "D6RRB7", "gene_name": "map2k7", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "D6RRB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D6RRB7" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "D6RRB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D6RRB7" } ] } ] }, { "uniprot_ac": "E7F063", "gene_name": "si:ch73-340m8.2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E7F063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E7F063" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E7F063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E7F063" } ] } ] }, { "uniprot_ac": "E7F2W4", "gene_name": "epha5", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E7F2W4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E7F2W4" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "E7F2W4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E7F2W4" } ] } ] }, { "uniprot_ac": "E7F3X9", "gene_name": "ddr1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E7F3X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E7F3X9" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "E7F3X9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E7F3X9" } ] } ] }, { "uniprot_ac": "E7F533", "gene_name": "epha2b", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E7F533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E7F533" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "E7F533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E7F533" } ] } ] }, { "uniprot_ac": "E7FEW6", "gene_name": "tesk1b", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E7FEW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E7FEW6" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "E7FEW6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E7FEW6" } ] } ] }, { "uniprot_ac": "E7FFT8", "gene_name": "ddr2a", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "E7FFT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E7FFT8" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "E7FFT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E7FFT8" } ] } ] }, { "uniprot_ac": "F1QJD4", "gene_name": "epha4l", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1QJD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1QJD4" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1QJD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1QJD4" } ] } ] }, { "uniprot_ac": "F1QKJ0", "gene_name": "ntrk3a", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1QKJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1QKJ0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1QKJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1QKJ0" } ] } ] }, { "uniprot_ac": "F1QVU0", "gene_name": "ltk", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1QVU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1QVU0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1QVU0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1QVU0" } ] } ] }, { "uniprot_ac": "F1QWE3", "gene_name": "mertka", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1QWE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1QWE3" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1QWE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1QWE3" } ] } ] }, { "uniprot_ac": "F1QWX8", "gene_name": "jak2a", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1QWX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1QWX8" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F1QWX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1QWX8" } ] } ] }, { "uniprot_ac": "F1RDG9", "gene_name": "fynb", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F1RDG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1RDG9" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F1RDG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1RDG9" } ] } ] }, { "uniprot_ac": "F6P1M3", "gene_name": "ntrk1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6P1M3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6P1M3" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F6P1M3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6P1M3" } ] } ] }, { "uniprot_ac": "F6P3V1", "gene_name": "epha6", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F6P3V1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6P3V1" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F6P3V1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F6P3V1" } ] } ] }, { "uniprot_ac": "F8W2F9", "gene_name": "abl1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F8W2F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F8W2F9" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F8W2F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F8W2F9" } ] } ] }, { "uniprot_ac": "F8W3R9", "gene_name": "alk", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "F8W3R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F8W3R9" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F8W3R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F8W3R9" } ] } ] }, { "uniprot_ac": "O12990", "gene_name": "jak1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "O12990", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O12990" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "O12990", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O12990" } ] } ] }, { "uniprot_ac": "O13146", "gene_name": "epha3", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "O13146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O13146" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "O13146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O13146" } ] } ] }, { "uniprot_ac": "O13147", "gene_name": "ephb3", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "O13147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O13147" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "O13147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O13147" } ] } ] }, { "uniprot_ac": "O13148", "gene_name": "epha4a", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "O13148", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O13148" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "O13148", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O13148" } ] } ] }, { "uniprot_ac": "O73791", "gene_name": "tek", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "O73791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O73791" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "O73791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O73791" } ] } ] }, { "uniprot_ac": "O73792", "gene_name": "tie1", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "O73792", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O73792" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "O73792", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O73792" } ] } ] }, { "uniprot_ac": "O73875", "gene_name": "ephb4a", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "O73875", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O73875" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "O73875", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O73875" } ] } ] }, { "uniprot_ac": "O73878", "gene_name": "ephb4b", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "O73878", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O73878" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "O73878", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O73878" } ] } ] }, { "uniprot_ac": "Q08BY6", "gene_name": "ptk6b", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q08BY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08BY6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q08BY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q08BY6" } ] } ] }, { "uniprot_ac": "Q1JPZ3", "gene_name": "src", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1JPZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JPZ3" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q1JPZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1JPZ3" } ] } ] }, { "uniprot_ac": "Q1L8U4", "gene_name": "clk2a", "activity": [ { "ec_number": "2.7.12.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1L8U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1L8U4" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q1L8U4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1L8U4" } ] } ] }, { "uniprot_ac": "Q1LVG4", "gene_name": "insrb", "activity": [ { "ec_number": "2.7.10.1", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1LVG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LVG4" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q1LVG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LVG4" } ] } ] }, { "uniprot_ac": "Q1LX51", "gene_name": "wee2", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1LX51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LX51" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q1LX51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LX51" } ] } ] }, { "uniprot_ac": "Q1LY62", "gene_name": "map2k2a", "activity": [ { "ec_number": "2.7.12.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1LY62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LY62" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q1LY62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LY62" } ] } ] }, { "uniprot_ac": "Q1LYE1", "gene_name": "wee1", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1LYE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LYE1" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q1LYE1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1LYE1" } ] } ] }, { "uniprot_ac": "Q1RLY5", "gene_name": "lck", "activity": [ { "ec_number": "2.7.10.2", "activity": "L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q1RLY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RLY5" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q1RLY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q1RLY5" } ] } ] }, { "uniprot_ac": "Q4V947", "gene_name": 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