The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, mitochondrial outer membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6NVC5-1", "Q6P3J6-1", "F1Q6B2-1", "A2BGT0-1", "A0A0R4IL71-1", "A5PLF8-1" ], "evidence": [ { "id": "R-DRE-5696872", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DRE-5696872" } ] }, { "id": "R-DRE-74730", "name": "Insulin degradation", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "endosome", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8AWD9-1", "A0A0R4IL71-1" ], "evidence": [ { "id": "R-DRE-74730", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DRE-74730" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A0R4IL71", "gene_name": "ide", "activity": [ { "ec_number": "3.4.24.56", "activity": "Degradation of insulin, glucagon and other polypeptides. No action on proteins.", "evidence": [ { "id": "A0A0R4IL71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IL71" } ] }, { "ec_number": "3.4.24.56", "activity": "", "evidence": [ { "id": "A0A0R4IL71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IL71" } ] } ] }, { "uniprot_ac": "A2BGT0", "gene_name": "usp30", "activity": [ { "ec_number": "3.4.19.12", "activity": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).", "evidence": [ { "id": "A2BGT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2BGT0" } ] }, { "ec_number": "3.4.19.12", "activity": "", "evidence": [ { "id": "A2BGT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A2BGT0" } ] } ] }, { "uniprot_ac": "A5PLF8", "gene_name": "mul1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A5PLF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PLF8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A5PLF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A5PLF8" } ] } ] }, { "uniprot_ac": "F1Q6B2", "gene_name": "ptrh2", "activity": [ { "ec_number": "3.1.1.29", "activity": "an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+).", "evidence": [ { "id": "F1Q6B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1Q6B2" } ] }, { "ec_number": "3.1.1.29", "activity": "", "evidence": [ { "id": "F1Q6B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1Q6B2" } ] } ] }, { "uniprot_ac": "Q6NVC5", "gene_name": "rhot1a", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q6NVC5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6NVC5" } ] } ] }, { "uniprot_ac": "Q6P3J6", "gene_name": "fkbp8", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q6P3J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6P3J6" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q6P3J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6P3J6" } ] } ] }, { "uniprot_ac": "Q8AWD9", "gene_name": "ctsd", "activity": [ { "ec_number": "3.4.23.5", "activity": "Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.", "evidence": [ { "id": "Q8AWD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8AWD9" } ] }, { "ec_number": "3.4.23.5", "activity": "", "evidence": [ { "id": "Q8AWD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8AWD9" } ] } ] } ], "biomarkers": [], "structures": [], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "3.4.24.56", "ec_name": "Degradation of insulin, glucagon and other polypeptides. No action on proteins.", "evidence": [ { "id": "3.4.24.56", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.4.24.56" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.agr", "label": "AGR Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 711, "end_pos": 713 }, { "start_pos": 81, "end_pos": 83 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 11 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }