{ "uniprot_canonical_ac": "A0A0R4IF65-1", "uniprot_ac": "A0A0R4IF65", "uniprot_id": "A0A0R4IF65_DANRE", "mass": { "chemical_mass": 100048.0, "monoisotopic_mass": 100048.0 }, "refseq": { "ac": "NP_775364", "name": "DNA replication licensing factor MCM2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775364" }, "gene_names": [ { "name": "mcm2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IF65", "id": "A0A0R4IF65" }, { "name": "cb737; chunp6905", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775364", "id": "NP_775364" }, { "name": "cb737", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IF65", "id": "A0A0R4IF65" }, { "name": "chunp6905", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IF65", "id": "A0A0R4IF65" }, { "name": "mcm2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775364", "id": "NP_775364" } ], "protein_names": [ { "name": "DNA replication licensing factor MCM2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IF65/entry#names_and_taxonomy", "id": "A0A0R4IF65" }, { "name": "3.6.4.12", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IF65/entry#names_and_taxonomy", "id": "A0A0R4IF65" }, { "name": "DNA replication licensing factor MCM2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775364", "id": "NP_775364" }, { "name": "DNA replication licensing factor mcm2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IF65/entry#names_and_taxonomy", "id": "A0A0R4IF65" }, { "name": "MCM2 minichromosome maintenance deficient 2, mitotin", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775364", "id": "NP_775364" } ], "function": [ { "annotation": "##Evidence-Data-START## Transcript exon combination :: GDQH01006067.1, BC066422.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000022.1 and EH588242.1. On Jun 25, 2015 this sequence version replaced NP_775364.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the reference strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.", "evidence": [ { "database": "RefSeq", "id": "NP_775364", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775364" } ] }, { "annotation": "The foxn1-mcm2 axis plays a central role in the genetic regulatory network controlling thymus development in zebrafish", "evidence": [ { "database": "RefSeq", "id": "NP_775364", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775364" }, { "database": "PubMed", "id": "23213226", "url": "https://glygen.org/publication/PubMed/23213226" } ] } ], "disease": [ { "disease_id": "DOID:0110592", "recommended_name": { "id": "DOID:0110592", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110592", "name": "autosomal dominant nonsyndromic deafness 70", "description": "An autosomal dominant nonsyndromic deafness that has_material_basis_in mutation in the MCM2 gene on chromosome 3q21." }, "synonyms": [ { "id": "DOID:0110592", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110592", "name": "DFNA70", "description": "" }, { "id": "DOID:0110592", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110592", "name": "autosomal dominant deafness 70", "description": "" }, { "id": "MONDO:0014853", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014853", "name": "autosomal dominant nonsyndromic hearing loss 70", "description": "Any autosomal dominant nonsyndromic deafness in which the cause of the disease is a mutation in the MCM2 gene." }, { "id": "MONDO:0014853", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014853", "name": "autosomal dominant nonsyndromic hearing loss 70", "description": "" }, { "id": "MONDO:0014853", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014853", "name": "DFNA70", "description": "" }, { "id": "MONDO:0014853", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014853", "name": "MCM2 autosomal dominant nonsyndromic deafness", "description": "" }, { "id": "MONDO:0014853", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014853", "name": "autosomal dominant deafness 70", "description": "" }, { "id": "MONDO:0014853", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014853", "name": "autosomal dominant nonsyndromic deafness 70", "description": "" }, { "id": "MONDO:0014853", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014853", "name": "autosomal dominant nonsyndromic deafness caused by mutation in MCM2", "description": "" }, { "id": "MONDO:0014853", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014853", "name": "autosomal dominant nonsyndromic deafness type 70", "description": "" }, { "id": "MONDO:0014853", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014853", "name": "deafness, autosomal dominant 70", "description": "" }, { "id": "MONDO:0014853", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014853", "name": "deafness, autosomal dominant type 70", "description": "" }, { "id": "MIM:616968", "resource": "MIM", "url": "https://www.omim.org/entry/616968", "name": "Deafness, autosomal dominant, 70", "description": "Deafness, autosomal dominant, 70" } ], "unlinked_id_list": [], "evidence": [ { "id": "0110592", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0110592" } ] }, { "disease_id": "DOID:10652", "recommended_name": { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimer's disease", "description": "A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid." }, "synonyms": [ { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimer disease", "description": "" }, { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimers dementia", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "10652", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10652" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Danio rerio", "taxid": 7955, "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IF65", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IF65" } ], "common_name": "Zebrafish", "glygen_name": "Zebrafish", "reference_species": "Danio rerio [7955]" } ], "gene": [ { "name": "mcm2", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IF65", "locus": {} } ], "crossref": [ { "id": "ZFIN:ZDB-GENE-020419-24", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-020419-24", "database": "AGR", "categories": [ "Protein Classification" ] }, { "id": "ENSDARG00000102798", "url": "https://bgee.org/?page=gene&gene_id=ENSDARG00000102798", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd17753", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17753", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "192338", "url": "https://www.ncbi.nlm.nih.gov/gene/192338", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001208", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001208", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008045", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008045", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012340", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012340", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018525", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018525", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027925", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027925", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031327", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031327", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033762", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033762", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041562", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041562", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dre:192338", "url": "https://www.genome.jp/dbget-bin/www_bget?dre:192338", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TYERVTT", "url": "https://omabrowser.org/oma/group/TYERVTT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A0R4IF65", "url": "https://www.orthodb.org/?gene=A0A0R4IF65", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11630", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11630", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11630:SF44", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11630:SF44", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00493", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00493", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF12619", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF12619", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF14551", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14551", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF17207", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17207", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF17855", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17855", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF23669", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23669", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "NP_775364", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775364", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "13065", "url": "https://www.rhea-db.org/rhea/13065", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A0R4IF65", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IF65", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0R4IF65-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IF65-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "ZDB-GENE-020419-24", "url": "https://zfin.org/ZDB-GENE-020419-24", "database": "ZFIN", "categories": [ "Protein", "Organism-specific" ] } ], "sequence": { "sequence": "MADSSESFNMATSPTRGSRRGDLTSSPGRDLPPFEDESEGLLGDTLPDEEDDDGEELIGDAMERDYRVIPELDRYEAEGLDEDEDLSELSPSARAEAEAAMRRRDREQGLGMGRIGRGLLYDSEDEDDKRPTKRQRVLAERAAEGGAMEGEDEEMIESIENLEDMKGHTVREWVSMAAPRLEIYHRFKNFLRTHVDEHGHNVFKERISDMCKENKESLLVNYEELASREHVLAYFLPEAPAEMLKIFDEAAKEVVLAMYPKYDRIAHEIHVRIGNLPLVEELRSLRQLHLNQLIRTSGVVTSCTGVLPQLGMVKYNCNKCNFILGPFFQSQNQEVKPGSCPECQSLGPFEINMEQTVYQNYQRITIQESPGKVAAGRLPRSKDAILLADLVDMCKPGDEIELTGIYHNNYDGSLNMANGFPVFATVILANHIARKDEGVAVAELTDEDVKAIVALSKDERIGERIFASIGPSIYAHEDIKRGLALALFGGEAKNPGGKHKVRGDINVLLCGDPGTAKSQFLKYVEKVASRAVFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENVDLTEPIISRFDVLCVVRDTVDPVQDEMLARFVVGSHIKHHPSNKEGGVAGLEEVVLPNTFDVPPIPQELLRKYIIYAKERVRPKLNQMDQDKVARIYSDLRKESMATGSIPITVRHIESMIRMAEAHARMHLRDYVLEDDVNMAIRVMLESFIDTQKFSVMRSMRKTFARYLAFRRDNNELLLFILKQLVSEQVSYQRNRYGAQQDTIEIAEKDLVDKARQINIHSLSAFYDSDLFRSNKFSHDVKKKLIVQQF", "length": 889, "header": "tr|A0A0R4IF65-1|A0A0R4IF65_DANRE Isoform 1 of DNA replication licensing factor MCM2 OS=Danio rerio OX=7955 GN=mcm2 PE=1 SV=1 CANONICAL=A0A0R4IF65-1" }, "isoforms": [ { "isoform_ac": "A0A0R4IF65-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IF65/entry#A0A0R4IF65-1", "sequence": { "sequence": "MADSSESFNMATSPTRGSRRGDLTSSPGRDLPPFEDESEGLLGDTLPDEEDDDGEELIGDAMERDYRVIPELDRYEAEGLDEDEDLSELSPSARAEAEAAMRRRDREQGLGMGRIGRGLLYDSEDEDDKRPTKRQRVLAERAAEGGAMEGEDEEMIESIENLEDMKGHTVREWVSMAAPRLEIYHRFKNFLRTHVDEHGHNVFKERISDMCKENKESLLVNYEELASREHVLAYFLPEAPAEMLKIFDEAAKEVVLAMYPKYDRIAHEIHVRIGNLPLVEELRSLRQLHLNQLIRTSGVVTSCTGVLPQLGMVKYNCNKCNFILGPFFQSQNQEVKPGSCPECQSLGPFEINMEQTVYQNYQRITIQESPGKVAAGRLPRSKDAILLADLVDMCKPGDEIELTGIYHNNYDGSLNMANGFPVFATVILANHIARKDEGVAVAELTDEDVKAIVALSKDERIGERIFASIGPSIYAHEDIKRGLALALFGGEAKNPGGKHKVRGDINVLLCGDPGTAKSQFLKYVEKVASRAVFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENVDLTEPIISRFDVLCVVRDTVDPVQDEMLARFVVGSHIKHHPSNKEGGVAGLEEVVLPNTFDVPPIPQELLRKYIIYAKERVRPKLNQMDQDKVARIYSDLRKESMATGSIPITVRHIESMIRMAEAHARMHLRDYVLEDDVNMAIRVMLESFIDTQKFSVMRSMRKTFARYLAFRRDNNELLLFILKQLVSEQVSYQRNRYGAQQDTIEIAEKDLVDKARQINIHSLSAFYDSDLFRSNKFSHDVKKKLIVQQF", "length": 889, "header": "tr|A0A0R4IF65-1|A0A0R4IF65_DANRE Isoform 1 of DNA replication licensing factor MCM2 OS=Danio rerio OX=7955 GN=mcm2 PE=1 SV=1 CANONICAL=A0A0R4IF65-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Identification of zebrafish insertional mutants with defects in visual system development and function.", "journal": "Genetics", "date": "2005", "authors": "Gross Jeffrey M, Perkins Brian D, Amsterdam Adam, Ega\u00f1a Ana, Darland Tristan, Matsui Jonathan I, Sciascia Salvatore, Hopkins Nancy, Dowling John E", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IF65", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IF65" } ], "reference": [ { "type": "PubMed", "id": "15716491", "url": "https://glygen.org/publication/PubMed/15716491" } ] }, { "title": "fgf20 is essential for initiating zebrafish fin regeneration.", "journal": "Science", "date": "2005", "authors": "Whitehead Geoffrey G, Makino Shinji, Lien Ching-Ling, Keating Mark T", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IF65", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IF65" } ], "reference": [ { "type": "PubMed", "id": "16373575", "url": "https://glygen.org/publication/PubMed/16373575" } ] }, { "title": "Aryl hydrocarbon receptor activation produces heart-specific transcriptional and toxic responses in developing zebrafish.", "journal": "Mol. Pharmacol.", "date": "2006", "authors": "Carney Sara A, Chen Jing, Burns C Geoffrey, Xiong Kong M, Peterson Richard E, Heideman Warren", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IF65", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IF65" } ], "reference": [ { "type": "PubMed", "id": "16714409", "url": "https://glygen.org/publication/PubMed/16714409" } ] }, { "title": "Mutation of the zebrafish nucleoporin elys sensitizes tissue progenitors to replication stress.", "journal": "PLoS Genet.", "date": "2008", "authors": "Davuluri Gangarao, Gong Weilong, Yusuff Shamila, Lorent Kristin, Muthumani Manimegalai, Dolan Amy C, Pack Michael", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IF65", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IF65" } ], "reference": [ { "type": "PubMed", "id": "18974873", "url": "https://glygen.org/publication/PubMed/18974873" } ] }, { "title": "Foxn1 maintains thymic epithelial cells to support T-cell development via mcm2 in zebrafish.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2012", "authors": "Ma Dongyuan, Wang Lu, Wang Sifeng, Gao Ya, Wei Yonglong, Liu Feng", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IF65", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IF65" }, { "database": "RefSeq", "id": "NP_775364", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775364" } ], "reference": [ { "type": "PubMed", "id": "23213226", "url": "https://glygen.org/publication/PubMed/23213226" } ] }, { "title": "The zebrafish reference genome sequence and its relationship to the human genome.", "journal": "Nature", "date": "2013", "authors": "Howe Kerstin, Clark Matthew D, Torroja Carlos F, Torrance James, Berthelot Camille, Muffato Matthieu, Collins John E, Humphray Sean, McLaren Karen, Matthews Lucy, McLaren Stuart, Sealy Ian, Caccamo Mario, Churcher Carol, Scott Carol, Barrett Jeffrey C, Koch Romke, Rauch Gerd-J\u00f6rg, White Simon, Chow William, Kilian Britt, Quintais Leonor T, Guerra-Assun\u00e7\u00e3o Jos\u00e9 A, Zhou Yi, Gu Yong, Yen Jennifer, Vogel Jan-Hinnerk, Eyre Tina, Redmond Seth, Banerjee Ruby, Chi Jianxiang, Fu Beiyuan, Langley Elizabeth, Maguire Sean F, Laird Gavin K, Lloyd David, Kenyon Emma, Donaldson Sarah, Sehra Harminder, Almeida-King Jeff, Loveland Jane, Trevanion Stephen, Jones Matt, Quail Mike, Willey Dave, Hunt Adrienne, Burton John, Sims Sarah, McLay Kirsten, Plumb Bob, Davis Joy, Clee Chris, Oliver Karen, Clark Richard, Riddle Clare, Elliot David, Eliott David, Threadgold Glen, Harden Glenn, Ware Darren, Begum Sharmin, Mortimore Beverley, Mortimer Beverly, Kerry Giselle, Heath Paul, Phillimore Benjamin, Tracey Alan, Corby Nicole, Dunn Matthew, Johnson Christopher, Wood Jonathan, Clark Susan, Pelan Sarah, Griffiths Guy, Smith Michelle, Glithero Rebecca, Howden Philip, Barker Nicholas, Lloyd Christine, Stevens Christopher, Harley Joanna, Holt Karen, Panagiotidis Georgios, Lovell Jamieson, Beasley Helen, Henderson Carl, Gordon Daria, Auger Katherine, Wright Deborah, Collins Joanna, Raisen Claire, Dyer Lauren, Leung Kenric, Robertson Lauren, Ambridge Kirsty, Leongamornlert Daniel, McGuire Sarah, Gilderthorp Ruth, Griffiths Coline, Manthravadi Deepa, Nichol Sarah, Barker Gary, Whitehead Siobhan, Kay Michael, Brown Jacqueline, Murnane Clare, Gray Emma, Humphries Matthew, Sycamore Neil, Barker Darren, Saunders David, Wallis Justene, Babbage Anne, Hammond Sian, Mashreghi-Mohammadi Maryam, Barr Lucy, Martin Sancha, Wray Paul, Ellington Andrew, Matthews Nicholas, Ellwood Matthew, Woodmansey Rebecca, Clark Graham, Cooper James D, Cooper James, Tromans Anthony, Grafham Darren, Skuce Carl, Pandian Richard, Andrews Robert, Harrison Elliot, Kimberley Andrew, Garnett Jane, Fosker Nigel, Hall Rebekah, Garner Patrick, Kelly Daniel, Bird Christine, Palmer Sophie, Gehring Ines, Berger Andrea, Dooley Christopher M, Ersan-\u00dcr\u00fcn Z\u00fcbeyde, Eser Cigdem, Geiger Horst, Geisler Maria, Karotki Lena, Kirn Anette, Konantz Judith, Konantz Martina, Oberl\u00e4nder Martina, Rudolph-Geiger Silke, Teucke Mathias, Lanz Christa, Raddatz G\u00fcnter, Osoegawa Kazutoyo, Zhu Baoli, Rapp Amanda, Widaa Sara, Langford Cordelia, Yang Fengtang, Schuster Stephan C, Carter Nigel P, Harrow Jennifer, Ning Zemin, Herrero Javier, Searle Steve M J, Enright Anton, Geisler Robert, Plasterk Ronald H A, Lee Charles, Westerfield Monte, de Jong Pieter J, Zon Leonard I, Postlethwait John H, N\u00fcsslein-Volhard Christiane, Hubbard Tim J P, Roest Crollius Hugues, Rogers Jane, Stemple Derek L", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IF65", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IF65" } ], "reference": [ { "type": "PubMed", "id": "23594743", "url": "https://glygen.org/publication/PubMed/23594743" } ] }, { "title": "Changes in the Expression of Pre-Replicative Complex Genes in hTERT and ALT Pediatric Brain Tumors.", "journal": "Cancers", "date": "2020", "authors": "Idilli Aurora Irene, Pagani Francesca, Kerschbamer Emanuela, Berardinelli Francesco, Bernab\u00e9 Manuel, Cayuela Mar\u00eda Luisa, Piazza Silvano, Poliani Pietro Luigi, Cusanelli Emilio, Mione Maria Caterina", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IF65", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IF65" } ], "reference": [ { "type": "PubMed", "id": "32331249", "url": "https://glygen.org/publication/PubMed/32331249" } ] }, { "title": "Zebrafish macrophage developmental arrest underlies depletion of microglia and reveals Csf1r-independent metaphocytes.", "journal": "Elife", "date": "2020", "authors": "Kuil Laura E, Oosterhof Nynke, Ferrero Giuliano, Mikul\u00e1\u0161ov\u00e1 Tereza, Hason Martina, Dekker Jordy, Rovira Mireia, van der Linde Herma C, van Strien Paulina Mh, de Pater Emma, Schaaf Gerben, Bindels Erik Mj, Wittamer Valerie, van Ham Tjakko J", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IF65", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IF65" } ], "reference": [ { "type": "PubMed", "id": "32367800", "url": "https://glygen.org/publication/PubMed/32367800" } ] }, { "title": "Ddx41 inhibition of DNA damage signaling permits erythroid progenitor expansion in zebrafish.", "journal": "Haematologica", "date": "2022", "authors": "Weinreb Joshua T, Gupta Varun, Sharvit Elianna, Weil Rachel, Bowman Teresa V", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IF65", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IF65" } ], "reference": [ { "type": "PubMed", "id": "33763998", "url": "https://glygen.org/publication/PubMed/33763998" } ] }, { "title": "Analysis of gene network bifurcation during optic cup morphogenesis in zebrafish.", "journal": "Nat. Commun.", "date": "2021", "authors": "Buono Lorena, Corbacho Jorge, Naranjo Silvia, Almuedo-Castillo Mar\u00eda, Moreno-Marmol Tania, de la Cerda Berta, Sanabria-Reinoso Estefan\u00eda, Polvillo Roc\u00edo, D\u00edaz-Corrales Francisco-Javier, Bogdanovic Ozren, Bovolenta Paola, Mart\u00ednez-Morales Juan-Ram\u00f3n", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IF65", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IF65" } ], "reference": [ { "type": "PubMed", "id": "34162866", "url": "https://glygen.org/publication/PubMed/34162866" } ] }, { "title": "Protein phosphatase 2A activators reverse age-related behavioral changes by targeting neural cell senescence.", "journal": "Aging Cell", "date": "2023", "authors": "Xing Jun, Chen Kehua, Gao Shuaiyun, Pousse M\u00e9lanie, Ying Yilin, Wang Bo, Chen Lianxiang, Wang Cuicui, Wang Lei, Hu Weiguo, Lu Yiming, Gilson Eric, Ye Jing", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IF65", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IF65" } ], "reference": [ { "type": "PubMed", "id": "36644807", "url": "https://glygen.org/publication/PubMed/36644807" } ] } ], "pathway": [ { "id": "dre:192338", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?dre:192338", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V1AFJ9-1", "protein_name": "DNA replication licensing factor MCM2", "gene_name": "MCM2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MADSSESQAAVTSPVRSSRRGDAFTSSPGRDLPPFEDESEGLLGTGGLPEDEEEGEELIGEGMERDYRPIPELDVYEAEGLALDDEDVEELTASQREAAERVMRQRDRELEQGMGRMRRGLLYDSDDEDEDRPLRKRRLAERAADGVEEEDEDMIESIENLEDMKGHSVREWVSMAAPRLEIYHRFKNFLKTHVDDHGHNVFKERISDMCKENRESLVVNYEDLAAQEHVLAYFLPEAPAEMLKIFDEAAKEVVLAMYPKYDRIAQEIHVRISHLPLVEELRSLRQLHLNQLIRTSGVVTSCTGVLPQLSMVKYNCTKCSFILGPFFQSQNQEVKPGSCPECQSLGPFEINMEETVYQNYQRIKIQESPGKVAAGRLPRSKDAILLADLVDSCKPGDEIELTGIYHNNYDGSLNTANGFPVFATVILANHIAKKDNKLAVGELTDEDVKMLVALSKDEQIGEKIFASIAPSIYGHEDIKRGLALALFGGEPKNPGGKHKVRGDINVLLCGDPGTAKSQFLKYIEKVSSRAIFTTGQGASAVGLTAYVQRHPVSKEWTLEAGALVLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENVDLTEPIISRFDILCVVRDTVDPVQDEMLARFVVNSHVKHHPGSKEAVNGDADEVILPNTYGVEPLPQEILRKYIVYAKEKVHPKLNQMDQDKVARMYTDLRKESMATGSIPITVRHIESMIRMAEAHARMHLRDYVVEDDVNMAIRVMLESFIDTQKFSVMRSMRKTFSRYLSFKRDNNELLLFILKQLVAEQVMYQRNRYGAQQDTIEVPEKDLVDKARQINIHNLSAFYDSEVFKMNRFSRDVKRKLIVQQF", "length": 888 }, "evidence": [ { "id": "A0A0R4IF65", "url": "https://omabrowser.org/oma/group/A0A0R4IF65/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "D3ZP96-1", "protein_name": "DNA replication licensing factor MCM2", "gene_name": "Mcm2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAESSESFSAASSPAPQRRRISDPLTSSPGRSSRRADALTSSPGRDLPPFEDESEGLLGTEGPVEEEEDGEELIGDGMERDYRPIPELDVYEAEGLALDDEDVEELTASQREAAERAMRQRDREAGRGLGRMRRGLLYDSDEEDEERPARKRRHIERATEDGEEDEEMIESIENLEDLKGHSVREWVSMAGPRLEIHHRFKNFLRTHVDSHGHNVFKERISDMCKENRESLVVNYEDLAAREHVLAYFLPEAPAELLQIFDEAALEVVLAMYPKYDRITNHIHVRISHLPLVEELRSLRQLHLNQLIRTSGVVTSCTGVLPQLSMVKYNCSKCNFILGPFCQSQNQEVKPGSCPECQSTGPFEINMEETIYQNYQRIRIQESPGKVAAGRLPRSKDAILLADLVDSCKPGDEIELTGIYHNNYDGSLNTTNGFPVFATIILANHVAKKDNKVAVGELTDEDVKMITSLSKDQQIGEKIFASIAPSIYGHEDIKRGLALALFGGEPKNPGGKHKVRGDINVLLCGDPGTAKSQFLKYIEKVSSRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENVDLTEPIISRFDVLCVVRDTVDPVQDEMLARFVVGSHVRHHPSNKKDEGLTNGGTTEPAMPNTYGVEPLPQEVLKKYIIYAKERVRPKLNQMDQDKVARMYSDLRKESMATGSIPITVRHIESMIRMAEAHARMHLRDYVMEDDVNMAIRVMLESFIDTQKFSVMRSMRKTFARYLSFRRDNNDLLLFILKQLVAEQVTYQRNRFGAQQDTIEIPEKDLMDKARQINIHNLSAFYDSDLFKINKFSRDLKRKLILQQF", "length": 905 }, "evidence": [ { "id": "HGNC:6944", "url": "https://alliancegenome.org/gene/HGNC:6944#orthology", "database": "AGR" }, { "id": "A0A0R4IF65", "url": "https://omabrowser.org/oma/group/A0A0R4IF65/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1SPF3-1", "protein_name": "DNA replication licensing factor MCM2", "gene_name": "MCM2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAESSESFTVASSPAPRRRGSDPLTSSPGRSSRRTDALTSSPGRDLPPFEDESEGLLGTEGPLEEEEEDGEELIGDGMERDYRAIPELDVYEPEGLALDDEDVEELTASQREAAERAMRQRDREAGRGLGRMRRGLLYDSDEEEEERPSRKRRQVERATEDGEEDEEMIESIENLEDLKGHSVREWVSMAGPRLEIHHRFKNFLRTHVDGHGHNVFKERISDMCKENRESLVVNYEDLAAREHVLAYFLPEAPAELLQIFDEAALEVVLAMYPKYDRIASHIHVRISHLPLVEELRSLRQLHLNQLIRTSGVVTSCTGVLPQLSMVKYNCNKCGFVLGPFCQSQNQEVKPGSCPECQSAGPFEVNMEETIYQNYQRIRIQESPGKVAAGRLPRSKDAILLADLVDSCKPGDEIELTGIYHNNYDGALNTANGFPVFATVILANHVAKKDNKVAVGELTDEDVKMITSLSKDQQIGEKIFASIAPSIYGHEDIKRGLALALFGGEPKNPGGKHKVRGDINVLLCGDPGTAKSQFLKYIEKVSSRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENVDLTEPIISRFDILCVVRDTVDPVQDEMLARFVVGSHVRHHPSNKEDGGLGGTPEPAMPNTYGVEPLPQEVLRKYIIYAKEKVHPKLNQMDQDKVAKMYSDLRKESMATGSIPITVRHIESMIRMAEAHARIHLRDYVMEDDVNMAIRVMLESFVDTQKFSVMRSMRKTFARYLSFRRDNNELLLFILKQLVAEQVAYQRSRFGAQQDTIEVPEKDLVDKARQINIHNLSAFYDSELFRMNKFSHDLKRKVILQQF", "length": 903 }, "evidence": [ { "id": "A0A0R4IF65", "url": "https://omabrowser.org/oma/group/A0A0R4IF65/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "G3H7V9-1", "protein_name": "DNA replication licensing factor MCM2", "gene_name": "Mcm2", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAESSESFSAASSPAQQRRRISDPLTSSPGRSSRRADALTSSPGRDLPPFEDESEGLLGTEGPVEEEEDGEELIGDGMERDYRPIPELDVYEAEGLALDDEDVEELTASQREAAERAMRQRDREAGRGLGRMRRGLLYDSDEEDEERPARKRRQVERATEDGEEDEEMIESIENLEDLKGHSVREWVSMAGPRLEIHHRFKNFLRTHVDSHGHNVFKERISDMCKENRESLVVNYEDLAAREHVLAYFLPEAPAELLQIFDEAALEVVLAMYPKYDRITNHIHVRISHLPLVEELRSLRQLHLNQLIRTSGVVTSCTGVLPQLSMVKYNCSKCNFVLGPFCQSQNQEVKPGSCPECQSTGPFEINMEETIYQNYQRIRIQESPGKVAAGRLPRSKDAILLADLVDSCKPGDEIELTGIYHNNYDGSLNTANGFPVFATVILANHVAKKDNKVAVGELTDEDVKMITSLSKDQQIGEKIFASIAPSIYGHEDIKRGLALALFGGEPKNPGGKHKVRGDINVLLCGDPGTAKSQFLKYIEKVSSRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENVDLTEPIISRFDILCVVRDTVDPVQDEMLARFVVGSHVRHHPSNKKDEGLTNGSILEPAMPNTYGVEPLPQEVLKKYIIYAKERVHPKLNQMDQDKVARMYSDLRKESMATGSIPITVRHIESMIRMAEAHARMHLRDYVMEDDVNMAIRVMLESFIDTQKFSVMRSMRKTFARYLSFRRDNNELLLFILKQLVAEQVTYQRNRFGAQQDTIEIPEKDLVDKARQINIHNLSAFYDSELFRINKFSRDLKRKMILQQF", "length": 905 }, "evidence": [ { "id": "A0A0R4IF65", "url": "https://omabrowser.org/oma/group/A0A0R4IF65/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "P29469-1", "protein_name": "DNA replication licensing factor MCM2", "gene_name": "MCM2", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSDNRRRRREEDDSDSENELPPSSPQQHFRGGMNPVSSPIGSPDMINPEGDDNEVDDVPDIDEVEEQMNEVDLMDDNMYEDYAADHNRDRYDPDQVDDREQQELSLSERRRIDAQLNERDRLLRNVAYIDDEDEEQEGAAQLDEMGLPVQRRRRRRQYEDLENSDDDLLSDMDIDPLREELTLESLSNVKANSYSEWITQPNVSRTIARELKSFLLEYTDETGRSVYGARIRTLGEMNSESLEVNYRHLAESKAILALFLAKCPEEMLKIFDLVAMEATELHYPDYARIHSEIHVRISDFPTIYSLRELRESNLSSLVRVTGVVTRRTGVFPQLKYVKFNCLKCGSILGPFFQDSNEEIRISFCTNCKSKGPFRVNGEKTVYRNYQRVTLQEAPGTVPPGRLPRHREVILLADLVDVSKPGEEVEVTGIYKNNYDGNLNAKNGFPVFATIIEANSIKRREGNTANEGEEGLDVFSWTEEEEREFRKISRDRGIIDKIISSMAPSIYGHRDIKTAVACSLFGGVPKNVNGKHSIRGDINVLLLGDPGTAKSQILKYVEKTAHRAVFATGQGASAVGLTASVRKDPITKEWTLEGGALVLADKGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTTLQARCSIIAAANPNGGRYNSTLPLAQNVSLTEPILSRFDILCVVRDLVDEEADERLATFVVDSHVRSHPENDEDREGEELKNNGESAIEQGEDEINEQLNARQRRLQRQRKKEEEISPIPQELLMKYIHYARTKIYPKLHQMDMDKVSRVYADLRRESISTGSFPITVRHLESILRIAESFAKMRLSEFVSSYDLDRAIKVVVDSFVDAQKVSVRRQLRRSFAIYTLGH", "length": 868 }, "evidence": [ { "id": "HGNC:6944", "url": "https://alliancegenome.org/gene/HGNC:6944#orthology", "database": "AGR" }, { "id": "A0A0R4IF65", "url": "https://omabrowser.org/oma/group/A0A0R4IF65/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P49735-1", "protein_name": "DNA replication licensing factor Mcm2", "gene_name": "Mcm2", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MDNPSSPPPNTPSDAAERRDLRAAMTSPVGDFEPFENEDEILGDQTVRDEAEEEDGEELFGDNMENDYRPMPELDHYDPALLDDEDDFSEMSQGDRFAAESEMRRRDRAAGIHRDDRDLGFGQSDDEDDVGPRAKRRAGEKAAVGEVEDTEMVESIENLEDTKGHSTKEWVSMLGPRTEIANRFQSFLRTFVDERGAYTYRDRIRRMCEQNMSSFVVSYTDLANKEHVLAYFLPEAPFQMLEIFDKVAKDMVLSIFPTYERVTTEIHVRISELPLIEELRTFRKLHLNQLVRTLGVVTATTGVLPQLSVIKYDCVKCGYVLGPFVQSQNTEIKPGSCPECQSTGPFSINMEQTLYRNYQKITLQESPGRIPAGRIPRSKDVILLADLCDQCKPGDELEVTGIYTNNYDGSLNTDQGFPVFATVIIANHVVVKDSKQVVQSLTDEDIATIQKLSKDPRIVERVVASMAPSIYGHDYIKRALALALFGGESKNPGEKHKVRGDINLLICGDPGTAKSQFLKYTEKVAPRAVFTTGQGASAVGLTAYVRRNPVSREWTLEAGALVLADQGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSMTFSENVNLSEPILSRFDVLCVVKDEFDPMQDQQLAKFVVHSHMKHHPSEEEQPELEEPQLKTVDEIPQDLLRQYIVYAKENIRPKLTNIDEDKIAKMYAQLRQESFATGSLPITVRHIESVIRMSEAHARMHLRENVMEADVSMAIRMMLESFIEAQKFSVMKKMRSTFQKYLSFQKDHSELLFFILRQLTLDQLAYIRCKDGPGATHVEIMERDLIERAKQLDIVNLKPFYESDLFRTNGFSYDPKRRIILQIVVDGNTA", "length": 887 }, "evidence": [ { "id": "HGNC:6944", "url": "https://alliancegenome.org/gene/HGNC:6944#orthology", "database": "AGR" }, { "id": "A0A0R4IF65", "url": "https://omabrowser.org/oma/group/A0A0R4IF65/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "P49736-1", "protein_name": "DNA replication licensing factor MCM2", "gene_name": "MCM2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAESSESFTMASSPAQRRRGNDPLTSSPGRSSRRTDALTSSPGRDLPPFEDESEGLLGTEGPLEEEEDGEELIGDGMERDYRAIPELDAYEAEGLALDDEDVEELTASQREAAERAMRQRDREAGRGLGRMRRGLLYDSDEEDEERPARKRRQVERATEDGEEDEEMIESIENLEDLKGHSVREWVSMAGPRLEIHHRFKNFLRTHVDSHGHNVFKERISDMCKENRESLVVNYEDLAAREHVLAYFLPEAPAELLQIFDEAALEVVLAMYPKYDRITNHIHVRISHLPLVEELRSLRQLHLNQLIRTSGVVTSCTGVLPQLSMVKYNCNKCNFVLGPFCQSQNQEVKPGSCPECQSAGPFEVNMEETIYQNYQRIRIQESPGKVAAGRLPRSKDAILLADLVDSCKPGDEIELTGIYHNNYDGSLNTANGFPVFATVILANHVAKKDNKVAVGELTDEDVKMITSLSKDQQIGEKIFASIAPSIYGHEDIKRGLALALFGGEPKNPGGKHKVRGDINVLLCGDPGTAKSQFLKYIEKVSSRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENVDLTEPIISRFDILCVVRDTVDPVQDEMLARFVVGSHVRHHPSNKEEEGLANGSAAEPAMPNTYGVEPLPQEVLKKYIIYAKERVHPKLNQMDQDKVAKMYSDLRKESMATGSIPITVRHIESMIRMAEAHARIHLRDYVIEDDVNMAIRVMLESFIDTQKFSVMRSMRKTFARYLSFRRDNNELLLFILKQLVAEQVTYQRNRFGAQQDTIEVPEKDLVDKARQINIHNLSAFYDSELFRMNKFSHDLKRKMILQQF", "length": 904 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-020419-24", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-020419-24#orthology", "database": "AGR" }, { "id": "HGNC:6944", "url": "https://alliancegenome.org/gene/HGNC:6944#orthology", "database": "AGR" }, { "id": "A0A0R4IF65", "url": "https://omabrowser.org/oma/group/A0A0R4IF65/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P97310-1", "protein_name": "DNA replication licensing factor MCM2", "gene_name": "Mcm2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAESSESLSASSPARQRRRISDPLTSSPGRSSRRADALTSSPGRDLPPFEDESEGLLGTEGPMEEEEDGEELIGDGMERDYRPIPELDVYEAEGLALDDEDVEELTASQREAAERTMRQRDREAGRGLGRMRRGLLYDSSEEDEERPARKRRHVERATEDGEEDEEMIESIENLEDLKGHSVREWVSMAGPRLEIHHRFKNFLRTHVDSHGHNVFKERISDMCKENRESLVVNYEDLAAREHVLAYFLPEAPAELLQIFDEAALEVVLAMYPKYDRITNHIHVRISHLPLVEELRSLRQLHLNQLIRTSGVVTSCTGVLPQLSMVKYNCSKCNFVLGPFCQSQNQEVKPGSCPECQSAGPFEINMEETIYQNYQRIRIQESPGKVAAGRLPRSKDAILLADLVDSCKPGDEIELTGIYHNNYDGSLNTANGFPVFATIILANHVAKKDNKVAVGELTDEDVKMITGLSKDQQIGEKIFASIAPSIYGHEDIKRGLALALFGGEPKNPGGKHKVRGDINVLLCGDPGTAKSQFLKYIEKVSSRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENVDLTEPIISRFDVLCVVRDTVDPVQDEMLARFVVGSHVRHHPSNKKDEGLTNGGTLEPAMPNTYGVEPLPQEVLKKYIIYAKERVRPKLNQMDQDKVARMYSDLRKESMATGSIPITVRHIESMIRMAEAHARMHLRDYVMEDDVNMAIRVMMESFIDTQKFSVMRSMRKTFARYLSFRRDNNDLLLFILKQLVAEQVTYQRNRFGAQQDTIEIPEKDLMDKARQINIHNLSAFYDSDLFKFNKFSRDLKRKLILQQF", "length": 904 }, "evidence": [ { "id": "HGNC:6944", "url": "https://alliancegenome.org/gene/HGNC:6944#orthology", "database": "AGR" }, { "id": "A0A0R4IF65", "url": "https://omabrowser.org/oma/group/A0A0R4IF65/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9LPD9-1", "protein_name": "DNA replication licensing factor MCM2", "gene_name": "MCM2", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MAGENSDNEPSSPASPSSAGFNTDQLPISTSQNSENFSDEEEAAVDTQVIRDEPDEAEDEEEEEGEDLFNDTFMNDYRKMDENDQYESNGIDDSVDDERDLGQAMLDRRAADADLDARENRLANRKLPHLLHDNDSDDWNYRPSKRSRTTVPPRGNGGDPDGNPPSSPGVSQPDISMTDQTDDYQDEDDNDDEAEFEMYRIQGTLREWVMRDEVRRFIAKKFKDFLLTYVKPKNENGDIEYVRLINEMVSANKCSLEIDYKEFIHVHPNIAIWLADAPQPVLEVMEEVSEKVIFDLHPNYKNIHTKIYVRVTNLPVNDQIRNIRQIHLNTMIRIGGVVTRRSGVFPQLQQVKYDCNKCGAVLGPFFQNSYSEVKVGSCSECQSKGPFTVNVEQTIYRNYQKLTIQESPGTVPAGRLPRHKEVILLNDLIDCARPGEEIEVTGIYTNNFDLSLNTKNGFPVFATVVEANYVTKKQDLFSAYKLTQEDKTQIEELSKDPRIVERIIKSIAPSIYGHEDIKTALALAMFGGQEKNIKGKHRLRGDINVLLLGDPGTAKSQFLKYVEKTGQRAVYTTGKGASAVGLTAAVHKDPVTREWTLEGGALVLADRGICLIDEFDKMNDQDRVSIHEAMEQQSISISKAGIVTSLQARCSVIAAANPVGGRYDSSKSFAQNVELTDPILSRFDILCVVKDVVDPVTDEMLAEFVVNSHFKSQPKGGKMEDSDPEDGIQGSSGSTDPEVLPQNLLKKYLTYSKLYVFPKLGELDAKKLETVYANLRRESMNGQGVSIATRHLESMIRMSEAHARMHLRQYVTEEDVNMAIRVLLDSFISTQKFGVQRTLRESFKRYITYKKDFNSLLLVLLKELVKNALKFEEIISGSNSGLPTIEVKIEELQTKAKEYDIADLRPFFSSTDFSKAHFELDHGRGMIKCPKRLITW", "length": 936 }, "evidence": [ { "id": "A0A0R4IF65", "url": "https://omabrowser.org/oma/group/A0A0R4IF65/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IF65", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IF65" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IF65", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IF65" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IF65", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IF65" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IF65", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IF65" } ], "pmid": "" }, { "name": "single-stranded DNA binding", "id": "GO:0003697", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003697", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IF65", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IF65" } ], "pmid": "" }, { "name": "helicase activity", "id": "GO:0004386", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004386", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IF65", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IF65" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IF65", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IF65" } ], "pmid": "" }, { "name": "MCM complex", "id": "GO:0042555", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042555", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IF65", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IF65" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "DNA replication", "id": "GO:0006260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006260", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IF65", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IF65" } ], "pmid": "" }, { "name": "retina development in camera-type eye", "id": "GO:0060041", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060041", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IF65", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IF65" } ], "pmid": "" }, { "name": "thymus development", "id": "GO:0048538", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048538", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IF65", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IF65" } ], "pmid": "" }, { "name": "regulation of cilium assembly", "id": "GO:1902017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902017", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IF65", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IF65" } ], "pmid": "" }, { "name": "mitotic DNA replication initiation", "id": "GO:1902975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902975", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IF65", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IF65" } ], "pmid": "" }, { "name": "double-strand break repair via break-induced replication", "id": "GO:0000727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000727", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IF65", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IF65" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13065", "name": "", "equation": "ATP + H2O = ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8JGR1-1", "A0A8M3ARX1-1", "A4IG62-1", "P83571-1", "A0AB32TYU1-1", "A0A8M3B1M6-1", "E7FG27-1", "A0A8M9PEX3-1", "A0A8M3B604-1", "A0A8M9PQC3-1", "A0A8M2BGA5-1", "Q6P404-1", "A0A8M9Q954-1", "P0C928-1", "F1Q8K0-1", "F1R345-1", "Q1LX78-1", "Q4TVV3-1", "A0A4P2L339-1", "F1QGL1-1", "A0A8M3AXS2-1", "Q6NZV2-1", "Q7ZU99-1", "Q7ZVA6-1", "Q8AWW7-1", "A2BGR3-1", "A3KMS0-1", "B8A4F4-1", "B0R0I6-1", "Q6NV07-1", "B0R061-1", "E7F1C4-1", "E9QEA3-1", "P0C218-1", "Q5RIC5-1", "A0A0E3D804-1", "A0A0R4IJV5-1", "A0A8M1P3F9-1", "A0A8M1P9J6-1", "O42107-1", "Q8JHJ2-1", "Q7ZU90-1", "Q7ZVF9-1", "Q7ZVI7-1", "Q7ZVV1-1", "A0A8N7T870-1", "A0A8M9PRM2-1", "A0A8N7TE51-1", "A0A8M3B137-1", "B3DFU8-1", "A0A8M9PQY5-1", "B8JKC1-1", "E7F3I8-1", "A0A8N7T8I5-1", "F1RBT2-1", "A0A8M9PSF9-1", "A0A8M9Q925-1", "A0A8M9PHB7-1", "F1R2L8-1", "Q6DRI7-1", "Q4V9J1-1", "F1QDI9-1", "Q1LXK4-1", "Q1LXK5-1", "Q6P9Z2-1", "F1Q5E7-1", "F8W3D4-1", "Q6DRN0-1", "F1QGG3-1", "F1QUY3-1", "M9MM98-1", "F1R166-1", "Q6DRL1-1", "A0A8M1NHJ3-1", "A0A8M1RMN7-1", "Q7ZV60-1", "X1WCM8-1", "Q7ZVL6-1", "A0A8M9PIH1-1", "A0A8M9P056-1", "Q802C9-1", "Q8JGR2-1", "Q7ZU67-1", "Q7ZVV8-1", "E7FAV9-1", "X1WET4-1", "A0A8M9QAI9-1", "Q29RA2-1", "Q08BA5-1", "B8A609-1", "A0A2R8Q3V8-1", "A0A8M9QFI7-1", "A0A0R4I9Y1-1", "A0A0R4IBK5-1", "B0UYS3-1", "A0AB32TJS0-1", "A0AB32TK84-1", "Q6DRE7-1", "A0A0D5W690-1", "X1WHV8-1", "F1QSB8-1", "Q08BL1-1", "Q6IQE5-1", "A0A8M1N2Y9-1", "A0A8M1N034-1", "A0AB32T984-1", "A0AB32TK19-1", "A0AB32TML8-1", "A0A8M2BG36-1", "A0AB32T1I3-1", "A0AB32TAM8-1", "A0AB32TJ06-1", "A0A0R4IF65-1", "Q7SZD3-1", "E7F8F4-1", "B2ZFP3-1", "A0A8M9PQW1-1", "A0A8M9QKH6-1", "Q32LU1-1", "Q5XJ12-1", "Q7ZV90-1", "Q6NVC5-1", "Q6P7X6-1", "A0A0R4ICC1-1", "A0A8M3AZR5-1", "A0A2R9YJN8-1", "B0S754-1", "E7F1G8-1", "E7F643-1", "E7FD91-1", "F1Q5L6-1", "F1QBS1-1", "F1QZ60-1", "A0A8M9QBU1-1", "E7F2M7-1", "B1H1M2-1", "E7F9J1-1", "F1Q4P2-1", "A0A8M9Q371-1", "Q502B4-1", "Q7ZUT9-1", "A0A8M1NYY8-1" ], "evidence": [ { "id": "13065", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13065" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A0D5W690", "gene_name": "rigi", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A0D5W690", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0D5W690" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A0D5W690", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0D5W690" } ] } ] }, { "uniprot_ac": "A0A0E3D804", "gene_name": "ifih1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A0E3D804", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0E3D804" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A0E3D804", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0E3D804" } ] } ] }, { "uniprot_ac": "A0A0R4I9Y1", "gene_name": "rnf213b", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "A0A0R4I9Y1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0R4I9Y1" } ] }, { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A0R4I9Y1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0R4I9Y1" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A0A0R4I9Y1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0R4I9Y1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A0R4I9Y1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0R4I9Y1" } ] } ] }, { "uniprot_ac": "A0A0R4IBK5", "gene_name": "rnf213a", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A0R4IBK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IBK5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A0R4IBK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IBK5" } ] }, { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "A0A0R4IBK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IBK5" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "A0A0R4IBK5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IBK5" } ] } ] }, { "uniprot_ac": "A0A0R4ICC1", "gene_name": "twnk", "activity": [ { "ec_number": "5.6.2.3", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A0R4ICC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ICC1" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0A0R4ICC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0R4ICC1" } ] } ] }, { "uniprot_ac": "A0A0R4IF65", "gene_name": "mcm2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A0R4IF65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IF65" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A0R4IF65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IF65" } ] } ] }, { "uniprot_ac": "A0A0R4IJV5", "gene_name": "ddx52", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A0R4IJV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IJV5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A0R4IJV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IJV5" } ] } ] }, { "uniprot_ac": "A0A2R8Q3V8", "gene_name": "dhx57", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A2R8Q3V8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A2R8Q3V8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A2R8Q3V8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A2R8Q3V8" } ] } ] }, { "uniprot_ac": "A0A2R9YJN8", "gene_name": "ddx21", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A2R9YJN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A2R9YJN8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A2R9YJN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A2R9YJN8" } ] } ] }, { "uniprot_ac": "A0A4P2L339", "gene_name": "ddx41", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A4P2L339", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A4P2L339" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A4P2L339", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A4P2L339" } ] } ] }, { "uniprot_ac": "A0A8M1N034", "gene_name": "AK6", "activity": [ { "ec_number": "2.7.4.3", "activity": "AMP + ATP = 2 ADP.", "evidence": [ { "id": "A0A8M1N034", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M1N034" } ] }, { "ec_number": "2.7.4.3", "activity": "", "evidence": [ { "id": "A0A8M1N034", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M1N034" } ] } ] }, { "uniprot_ac": "A0A8M1N2Y9", "gene_name": "abcc4", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0A8M1N2Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M1N2Y9" } ] }, { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "A0A8M1N2Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M1N2Y9" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "A0A8M1N2Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M1N2Y9" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "A0A8M1N2Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M1N2Y9" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": 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"activity": "", "evidence": [ { "id": "A0A8M1NYY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M1NYY8" } ] } ] }, { "uniprot_ac": "A0A8M1P3F9", "gene_name": "dhx9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A8M1P3F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M1P3F9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A8M1P3F9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M1P3F9" } ] } ] }, { "uniprot_ac": "A0A8M1P9J6", "gene_name": "mcm9", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A8M1P9J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M1P9J6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A8M1P9J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8M1P9J6" } 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