{ "uniprot_canonical_ac": "A0A0R4IB28-1", "uniprot_ac": "A0A0R4IB28", "uniprot_id": "A0A0R4IB28_DANRE", "mass": { "chemical_mass": 69455.0, "monoisotopic_mass": 69455.0 }, "refseq": { "ac": "XP_005157629", "name": "hypoxia inducible factor 1 subunit alpha, like isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005157629" }, "gene_names": [ { "name": "hif1al", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB28", "id": "A0A0R4IB28" }, { "name": "Hif-3alpha; zgc:63965", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005157629", "id": "XP_005157629" }, { "name": "Hif-3alpha", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB28", "id": "A0A0R4IB28" }, { "name": "hif1al", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005157629", "id": "XP_005157629" }, { "name": "zgc:63965", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB28", "id": "A0A0R4IB28" } ], "protein_names": [ { "name": "Hypoxia inducible factor 1 subunit alpha, like isoform X1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB28/entry#names_and_taxonomy", "id": "A0A0R4IB28" }, { "name": "Hypoxia-inducible factor 1 subunit alpha,-like", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB28/entry#names_and_taxonomy", "id": "A0A0R4IB28" }, { "name": "hypoxia inducible factor 1 subunit alpha, like isoform X1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005157629", "id": "XP_005157629" } ], "function": [ { "annotation": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133190) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Sep 24, 2014 this sequence version replaced XP_005157629.1. COMPLETENESS: full length.", "evidence": [ { "database": "RefSeq", "id": "XP_005157629", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005157629" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Danio rerio", "taxid": 7955, "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB28", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB28" } ], "common_name": "Zebrafish", "glygen_name": "Zebrafish", "reference_species": "Danio rerio [7955]" } ], "gene": [ { "name": "hif1al", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB28", "locus": {} } ], "crossref": [ { "id": "ZFIN:ZDB-GENE-040426-1315", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-040426-1315", "database": "AGR", "categories": [ "Protein Classification" ] }, { "id": "ENSDARG00000100826", "url": "https://bgee.org/?page=gene&gene_id=ENSDARG00000100826", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00130", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00130", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd19729", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19729", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "393376", "url": "https://www.ncbi.nlm.nih.gov/gene/393376", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000014", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000014", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001067", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001067", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001610", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001610", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013767", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013767", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021537", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021537", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035965", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035965", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036638", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036638", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dre:393376", "url": "https://www.genome.jp/dbget-bin/www_bget?dre:393376", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A0R4IB28", "url": "https://www.orthodb.org/?gene=A0A0R4IB28", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q7T2E4", "url": "https://www.orthodb.org/?gene=Q7T2E4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23043", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23043", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23043:SF34", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23043:SF34", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00989", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00989", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF11413", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11413", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF14598", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14598", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF23171", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23171", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "XP_005157629", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005157629", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A0R4IB28", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB28", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0R4IB28-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB28-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8M9QBW4", "url": "https://www.uniprot.org/uniprotkb/A0A8M9QBW4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8M9QBW4-1", "url": "https://www.uniprot.org/uniprotkb/A0A8M9QBW4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q7T2E4", "url": "https://www.uniprot.org/uniprotkb/Q7T2E4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q7T2E4-1", "url": "https://www.uniprot.org/uniprotkb/Q7T2E4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "ZDB-GENE-040426-1315", "url": "https://zfin.org/ZDB-GENE-040426-1315", "database": "ZFIN", "categories": [ "Protein", "Organism-specific" ] } ], "sequence": { "sequence": "MPSLEQRKVRSRDAARCRRSQETEVFYELAHSLPLPRRIASHLDKAAIMRVTLSYLRMNRLIQSGSTKSQTEKSETPTDGFYQQALAGFILVMTEEGDMVFLSESVSKYIGITQLELLGQSVYEFVHPCDQEELRDILATRPGVSKKKTMEHNFFLRMKSTLTHTGRTVNIKSATWKVLHCTGHMQPFSGDDENSPSAGSFLTLLCEPIPHPSSVEFPLDSSTFLTRHNLDLTYTQCDGRVTELVGYQPDDLIGRSAFEFFHALDFDHVSRSLHILFSKGQVCTGQYRFLAKNGGFVWTETQATVLYNSRTSQPEAVVCLNFILSGVEEQDVVFSLEQTCEKPKPKVERLMVLKEEQEDSDMEESSTAKLFLQMKENPEELLQLAPHSGDAIISLTEGLELSFCCPQSPNSVPECPQDFCTPELRKLLSPIFDGPAKSHPAASPAEELPMEMEGVEKFFALKPEESLTPKGQSEAVDELDLDMLAPYISMDDDFQLTFLPQSEITPPLEMLTSNSRKRCLEDDDDDDIPVLAARWDKKQMSGPIEDQLLLSHTLLDGLSDGSDEFEPPPQKRSQLLTDRDPLLGGVQALCDTAALMRDTFLSRPPDLRRPVGETLPSLT", "length": 619, "header": "tr|A0A0R4IB28-1|A0A0R4IB28_DANRE Isoform 1 of Hypoxia-inducible factor 1 subunit alpha,-like OS=Danio rerio OX=7955 GN=hif1al PE=4 SV=2 CANONICAL=A0A0R4IB28-1" }, "isoforms": [ { "isoform_ac": "A0A0R4IB28-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB28/entry#A0A0R4IB28-1", "sequence": { "sequence": "MPSLEQRKVRSRDAARCRRSQETEVFYELAHSLPLPRRIASHLDKAAIMRVTLSYLRMNRLIQSGSTKSQTEKSETPTDGFYQQALAGFILVMTEEGDMVFLSESVSKYIGITQLELLGQSVYEFVHPCDQEELRDILATRPGVSKKKTMEHNFFLRMKSTLTHTGRTVNIKSATWKVLHCTGHMQPFSGDDENSPSAGSFLTLLCEPIPHPSSVEFPLDSSTFLTRHNLDLTYTQCDGRVTELVGYQPDDLIGRSAFEFFHALDFDHVSRSLHILFSKGQVCTGQYRFLAKNGGFVWTETQATVLYNSRTSQPEAVVCLNFILSGVEEQDVVFSLEQTCEKPKPKVERLMVLKEEQEDSDMEESSTAKLFLQMKENPEELLQLAPHSGDAIISLTEGLELSFCCPQSPNSVPECPQDFCTPELRKLLSPIFDGPAKSHPAASPAEELPMEMEGVEKFFALKPEESLTPKGQSEAVDELDLDMLAPYISMDDDFQLTFLPQSEITPPLEMLTSNSRKRCLEDDDDDDIPVLAARWDKKQMSGPIEDQLLLSHTLLDGLSDGSDEFEPPPQKRSQLLTDRDPLLGGVQALCDTAALMRDTFLSRPPDLRRPVGETLPSLT", "length": 619, "header": "tr|A0A0R4IB28-1|A0A0R4IB28_DANRE Isoform 1 of Hypoxia-inducible factor 1 subunit alpha,-like OS=Danio rerio OX=7955 GN=hif1al PE=4 SV=2 CANONICAL=A0A0R4IB28-1" }, "locus": {} }, { "isoform_ac": "A0A8M9QBW4-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB28/entry#A0A8M9QBW4-1", "sequence": { "sequence": "MRHSVQVTCEFRPLGIGQILRGTQVDLVPCKLPGLNDILQTKLKKELGRMYQVKSVQDELELLGQSVYEFVHPCDQEELRDILATRPGVSKKKTMEHNFFLRMKSTLTHTGRTVNIKSATWKVLHCTGHMQPFSGDDENSPSAGSFLTLLCEPIPHPSSVEFPLDSSTFLTRHNLDLTYTQCDGRVTELVGYQPDDLIGRSAFEFFHALDFDHVSRSLHILFSKGQVCTGQYRFLAKNGGFVWTETQATVLYNSRTSQPEAVVCLNFILSGVEEQDVVFSLEQTCEKPKPKVERLMVLKEEQEDSDMEESSTAKLFLQMKENPEELLQLAPHSGDAIISLTEGLELSFCCPQSPNSVPECPQDFCTPELRKLLSPIFDGPAKSHPAASPAEELPMEMEGVEKFFALKPEESLTPKGQSEAVDELDLDMLAPYISMDDDFQLTFLPQSEITPPLEMLTSNSRKRCLEDDDDDDIPVLAARWDKKQMSGPIEDQLLLSHTLLDGLSDGSDEFEPPPQKRSQLLTDRDPLLGGVQALCDTAALMRDTFLSRPPDLRRPVGETLPSLT", "length": 564, "header": "tr|A0A8M9QBW4-1|A0A0R4IB28_DANRE Computationally mapped isoform of Hypoxia-inducible factor 1 subunit alpha,-like OS=Danio rerio OX=7955 GN=hif1al PE=4 SV=1 CANONICAL=A0A0R4IB28-1" }, "locus": {} }, { "isoform_ac": "Q7T2E4-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB28/entry#Q7T2E4-1", "sequence": { "sequence": "MRVTLSYLRMNRLIQSGSTKSQTEKSETPTDGFYQQALAGFILVMTEEGDMVFLSESVSKYIGITQLELLGQSVYEFVHPCDQEELRDILATRPGVSKKKTMEHNFFLRMKSTLTHTGRTVNIKSATWKVLHCTGHMQPFSGDDENSPSAGSFLTLLCEPIPHPSSVEFPLDSSTFLTRHNLDLTYTQCDGRVTELVGYQPDDLIGRSAFEFFHALDFDHVSRSLHILFSKGQVCTGQYRFLAKNGGFVWTETQATVLYNSRTSQPEAVVCLNFILSGVEEQDVVFSLEQTCEKPKPKVERLMVLKEEQEDSDMEESSTAKLFLQMKENPEELLQLAPHSGDAIISLTEGLELSFCCPQSPNSVPECPQDFCTPELRKLLSPIFDGPAKSPPAASPAEELPMEMEGVEKFFALKPEESLTPKGQSEAVDELDLDMLAPYISMDDDFQLTFLPQSEITPPLEMLTSNSRKRCLEDDDDDDIPVLAARWDKKQMSGSIEDQLLLSHTLLDGLSDGSDEFEPPPQKRSQLLTDRDPLLGGVQALCDTAALMRDTFLSRPPDLRRPVAETLPSLT", "length": 571, "header": "tr|Q7T2E4-1|A0A0R4IB28_DANRE Computationally mapped isoform of Hypoxia-inducible factor 1 subunit alpha,-like OS=Danio rerio OX=7955 GN=hif1al PE=4 SV=1 CANONICAL=A0A0R4IB28-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "start_pos": 505, "start_aa": "Thr", "end_pos": 505, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr505", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "00000000000000001000.00000000001000.0.xxxxx" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "start_pos": 78, "start_aa": "Thr", "end_pos": 78, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr78", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "00000000000000001000.00000000001000.0.xxxxx" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "In vivo long-term continuous observation of gene expression in zebrafish embryo nerve systems by using harmonic generation microscopy and morphant technology.", "journal": "J. Biomed. Opt.", "date": "2008", "authors": "Hsieh Cho-Shuen, Ko Ching-Yi, Chen Szu-Yu, Liu Tzu-Ming, Wu Jian-Shiung, Hu Chin-Hwa, Sun Chi-Kuang", "evidence": [ { "database": "UniProtKB", "id": "Q7T2E4", "url": "https://www.uniprot.org/uniprotkb/Q7T2E4" } ], "reference": [ { "type": "PubMed", "id": "19123687", "url": "https://glygen.org/publication/PubMed/19123687" } ] }, { "title": "Phylogenetic analysis of zebrafish basic helix-loop-helix transcription factors.", "journal": "J. Mol. Evol.", "date": "2009", "authors": "Wang Yong, Chen Keping, Yao Qin, Zheng Xiaodong, Yang Zhe", "evidence": [ { "database": "UniProtKB", "id": "Q7T2E4", "url": "https://www.uniprot.org/uniprotkb/Q7T2E4" } ], "reference": [ { "type": "PubMed", "id": "19449054", "url": "https://glygen.org/publication/PubMed/19449054" } ] }, { "title": "Chronic reduction in cardiac output induces hypoxic signaling in larval zebrafish even at a time when convective oxygen transport is not required.", "journal": "Physiol. Genomics", "date": "2010", "authors": "Kopp Renate, Schwerte Thorsten, Egg Margit, Sandbichler Adolf Michael, Egger Bernhard, Pelster Bernd", "evidence": [ { "database": "UniProtKB", "id": "Q7T2E4", "url": "https://www.uniprot.org/uniprotkb/Q7T2E4" } ], "reference": [ { "type": "PubMed", "id": "20571107", "url": "https://glygen.org/publication/PubMed/20571107" } ] }, { "title": "HIF signaling and overall gene expression changes during hypoxia and prolonged exercise differ considerably.", "journal": "Physiol. Genomics", "date": "2011", "authors": "Kopp Renate, K\u00f6blitz Louise, Egg Margit, Pelster Bernd", "evidence": [ { "database": "UniProtKB", "id": "Q7T2E4", "url": "https://www.uniprot.org/uniprotkb/Q7T2E4" } ], "reference": [ { "type": "PubMed", "id": "21343420", "url": "https://glygen.org/publication/PubMed/21343420" } ] }, { "title": "Molecular, functional, and gene expression analysis of zebrafish hypoxia-inducible factor-3alpha.", "journal": "Am. J. Physiol. Regul. Integr. Comp. Physiol.", "date": "2012", "authors": "Zhang Peng, Lu Ling, Yao Qing, Li Yun, Zhou Jianfeng, Liu Yunzhang, Duan Cunming", "evidence": [ { "database": "UniProtKB", "id": "Q7T2E4", "url": "https://www.uniprot.org/uniprotkb/Q7T2E4" } ], "reference": [ { "type": "PubMed", "id": "23034716", "url": "https://glygen.org/publication/PubMed/23034716" } ] }, { "title": "The zebrafish reference genome sequence and its relationship to the human genome.", "journal": "Nature", "date": "2013", "authors": "Howe Kerstin, Clark Matthew D, Torroja Carlos F, Torrance James, Berthelot Camille, Muffato Matthieu, Collins John E, Humphray Sean, McLaren Karen, Matthews Lucy, McLaren Stuart, Sealy Ian, Caccamo Mario, Churcher Carol, Scott Carol, Barrett Jeffrey C, Koch Romke, Rauch Gerd-J\u00f6rg, White Simon, Chow William, Kilian Britt, Quintais Leonor T, Guerra-Assun\u00e7\u00e3o Jos\u00e9 A, Zhou Yi, Gu Yong, Yen Jennifer, Vogel Jan-Hinnerk, Eyre Tina, Redmond Seth, Banerjee Ruby, Chi Jianxiang, Fu Beiyuan, Langley Elizabeth, Maguire Sean F, Laird Gavin K, Lloyd David, Kenyon Emma, Donaldson Sarah, Sehra Harminder, Almeida-King Jeff, Loveland Jane, Trevanion Stephen, Jones Matt, Quail Mike, Willey Dave, Hunt Adrienne, Burton John, Sims Sarah, McLay Kirsten, Plumb Bob, Davis Joy, Clee Chris, Oliver Karen, Clark Richard, Riddle Clare, Elliot David, Eliott David, Threadgold Glen, Harden Glenn, Ware Darren, Begum Sharmin, Mortimore Beverley, Mortimer Beverly, Kerry Giselle, Heath Paul, Phillimore Benjamin, Tracey Alan, Corby Nicole, Dunn Matthew, Johnson Christopher, Wood Jonathan, Clark Susan, Pelan Sarah, Griffiths Guy, Smith Michelle, Glithero Rebecca, Howden Philip, Barker Nicholas, Lloyd Christine, Stevens Christopher, Harley Joanna, Holt Karen, Panagiotidis Georgios, Lovell Jamieson, Beasley Helen, Henderson Carl, Gordon Daria, Auger Katherine, Wright Deborah, Collins Joanna, Raisen Claire, Dyer Lauren, Leung Kenric, Robertson Lauren, Ambridge Kirsty, Leongamornlert Daniel, McGuire Sarah, Gilderthorp Ruth, Griffiths Coline, Manthravadi Deepa, Nichol Sarah, Barker Gary, Whitehead Siobhan, Kay Michael, Brown Jacqueline, Murnane Clare, Gray Emma, Humphries Matthew, Sycamore Neil, Barker Darren, Saunders David, Wallis Justene, Babbage Anne, Hammond Sian, Mashreghi-Mohammadi Maryam, Barr Lucy, Martin Sancha, Wray Paul, Ellington Andrew, Matthews Nicholas, Ellwood Matthew, Woodmansey Rebecca, Clark Graham, Cooper James D, Cooper James, Tromans Anthony, Grafham Darren, Skuce Carl, Pandian Richard, Andrews Robert, Harrison Elliot, Kimberley Andrew, Garnett Jane, Fosker Nigel, Hall Rebekah, Garner Patrick, Kelly Daniel, Bird Christine, Palmer Sophie, Gehring Ines, Berger Andrea, Dooley Christopher M, Ersan-\u00dcr\u00fcn Z\u00fcbeyde, Eser Cigdem, Geiger Horst, Geisler Maria, Karotki Lena, Kirn Anette, Konantz Judith, Konantz Martina, Oberl\u00e4nder Martina, Rudolph-Geiger Silke, Teucke Mathias, Lanz Christa, Raddatz G\u00fcnter, Osoegawa Kazutoyo, Zhu Baoli, Rapp Amanda, Widaa Sara, Langford Cordelia, Yang Fengtang, Schuster Stephan C, Carter Nigel P, Harrow Jennifer, Ning Zemin, Herrero Javier, Searle Steve M J, Enright Anton, Geisler Robert, Plasterk Ronald H A, Lee Charles, Westerfield Monte, de Jong Pieter J, Zon Leonard I, Postlethwait John H, N\u00fcsslein-Volhard Christiane, Hubbard Tim J P, Roest Crollius Hugues, Rogers Jane, Stemple Derek L", "evidence": [ { "database": "UniProtKB", "id": "Q7T2E4", "url": "https://www.uniprot.org/uniprotkb/Q7T2E4" } ], "reference": [ { "type": "PubMed", "id": "23594743", "url": "https://glygen.org/publication/PubMed/23594743" } ] }, { "title": "Identification of Potentially Related Genes and Mechanisms Involved in Skeletal Muscle Atrophy Induced by Excessive Exercise in Zebrafish.", "journal": "Biology", "date": "2021", "authors": "Sun Chen-Chen, Zhou Zuo-Qiong, Chen Zhang-Lin, Zhu Run-Kang, Yang Dong, Peng Xi-Yang, Zheng Lan, Tang Chang-Fa", "evidence": [ { "database": "UniProtKB", "id": "Q7T2E4", "url": "https://www.uniprot.org/uniprotkb/Q7T2E4" } ], "reference": [ { "type": "PubMed", "id": "34439993", "url": "https://glygen.org/publication/PubMed/34439993" } ] }, { "title": "A lysosome-targeted dextran-doxorubicin nanodrug overcomes doxorubicin-induced chemoresistance of myeloid leukemia.", "journal": "J. Hematol. Oncol.", "date": "2021", "authors": "Zeng Yunxin, Zhang Xinyu, Lin Dongjun, Feng Xiaohui, Liu Yuye, Fang Zhengwen, Zhang Weijian, Chen Yu, Zhao Meng, Wu Jun, Jiang Linjia", "evidence": [ { "database": "UniProtKB", "id": "Q7T2E4", "url": "https://www.uniprot.org/uniprotkb/Q7T2E4" } ], "reference": [ { "type": "PubMed", "id": "34749790", "url": "https://glygen.org/publication/PubMed/34749790" } ] }, { "title": "Zebrafish Mutant Lines Reveal the Interplay between nr3c1 and nr3c2 in the GC-Dependent Regulation of Gene Transcription.", "journal": "Int. J. Mol. Sci.", "date": "2022", "authors": "Dinarello Alberto, Tesoriere Annachiara, Martini Paolo, Fontana Camilla Maria, Volpato Davide, Badenetti Lorenzo, Terrin Francesca, Facchinello Nicola, Romualdi Chiara, Carnevali Oliana, Dalla Valle Luisa, Argenton Francesco", "evidence": [ { "database": "UniProtKB", "id": "Q7T2E4", "url": "https://www.uniprot.org/uniprotkb/Q7T2E4" } ], "reference": [ { "type": "PubMed", "id": "35269817", "url": "https://glygen.org/publication/PubMed/35269817" } ] }, { "title": "Foxm1 regulates cardiomyocyte proliferation in adult zebrafish after cardiac injury.", "journal": "Development", "date": "2023", "authors": "Zuppo Daniel A, Missinato Maria A, Santana-Santos Lucas, Li Guang, Benos Panayiotis V, Tsang Michael", "evidence": [ { "database": "UniProtKB", "id": "Q7T2E4", "url": "https://www.uniprot.org/uniprotkb/Q7T2E4" } ], "reference": [ { "type": "PubMed", "id": "36846912", "url": "https://glygen.org/publication/PubMed/36846912" } ] }, { "title": "Zebrafish ELL-associated factors Eaf1/2 modulate erythropoiesis via regulating gata1a expression and WNT signaling to facilitate hypoxia tolerance.", "journal": "Cell Regen (Lond)", "date": "2023", "authors": "Liu WenYe, Lin ShuHui, Li LingYa, Tai ZhiPeng, Liu Jing-Xia", "evidence": [ { "database": "UniProtKB", "id": "Q7T2E4", "url": "https://www.uniprot.org/uniprotkb/Q7T2E4" } ], "reference": [ { "type": "PubMed", "id": "37002435", "url": "https://glygen.org/publication/PubMed/37002435" } ] } ], "pathway": [ { "id": "dre:393376", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?dre:393376", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8M2B8B7-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "hif1al2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTSMNLETGGEDCHGKARRKQTFIEQKKRRVCTEWRKTCSRLAAQSRRKKESQLFKELTALLPLDLSMDGQRDKASVIRLTIAYLHLRGLLDTTDSLMKRPSPGVSDKSHERELLDSALGGFVVLLSLNGKVIFATKGLTTHTGINQMDLIGRSLLEFLHPCDQMEVKDILTRLIGNQEPQKCEVFLRIKKAMNTKLTGWKIIQCSGKKRSSATPGSSCLVLECRVLPIQEITEVDEALNACTFMSVHSPDMTFTYCHSRVVKLIGFRDTDLLGQSVYQYYHPSDCQQIRKAHICLLSKGQVSTGKYRLLHRYGGYVWAETDASLVCNSQTGVPESVVCINYILSEVEQPNLPFLLEKTEQLLKPTSSSYCPETEPAPFPPSRGQEGEKDLKESNEHNSFITHLKQRDGDIQEVECTEIPHNTEGCYDFNCDQCELDLDSLAPYIPMHGEDFLLTPIIDRAMDMPELNTCRPSCSSPSQNLDSSEGTTVLPVKSLNSTQQSVSNSFQTKRISDTNLISTKQWSDSFDLVNKVSKVYDYDPKQHNYQLFSSETKANHWVEEALKFPQPNRVHWNIDGSTPPWICDGHLNHLEPKFRSLPEKTNCPPQKRRHQHEVKTAAALLTLPVLSGWECEVNAPLEHTSYLLQGTEIMAVLDQVASRVPWC", "length": 663 }, "evidence": [ { "id": "HGNC:15825", "url": "https://alliancegenome.org/gene/HGNC:15825#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q0VBL6-1", "protein_name": "Hypoxia-inducible factor 3-alpha", "gene_name": "Hif3a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDWDQDRSNTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAGEWNQVEKGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDALTPRPNLSKKKLEAPTERHFSLRMKSTLTSRGRTLNLKAATWKVLHCSGHMRAYKPPAQTSPAGSPRSEPPLQCLVLICEAIPHPASLEPPLGRGAFLSRHSLDMKFTYCDERIAEVAGYSPDDLIGCSAYEYIHALDSDAVSRSIHTLLSKGQAVTGQYRFLARTGGYLWTQTQATVVSGGRGPQSESIICVHFLISRVEETGVVLSLEQTEQHTRRPPRLSASSQKGIPGNSVDSPAPRILAFLHPPALSEASLAADPRRFCSPDLRRLMAPILDGPPPAATPSTPQATRRPQSPLPADLPDKLTVGLENAHRLSTAQKNKTVETDLDIAQDPDTLDLEMLAPYISMDDDFQLNSSEQLPKVHRRPPRVARRPRARSFHGLSPPIPEPSLLPRWGSDPRLNCSSPSRGDRPTASLMPGTRKRALAQSSEDKGLELLETKPPKRSPRLEPGSFLLPPLSLSFLLQGRQLPGNQQDPRAPLVHSHEPLGLAPSLLSLCQHEETVQPRNRFPPAAGLGQTH", "length": 662 }, "evidence": [ { "id": "HGNC:15825", "url": "https://alliancegenome.org/gene/HGNC:15825#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q24167-1", "protein_name": "Protein similar", "gene_name": "sima", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": 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"length": 1507 }, "evidence": [ { "id": "HGNC:15825", "url": "https://alliancegenome.org/gene/HGNC:15825#orthology", "database": "AGR" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9JHS2-1", "protein_name": "Hypoxia-inducible factor 3-alpha", "gene_name": "Hif3a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": 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sapiens", "sequence": { "sequence": "MALGLQRARSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRRPIQRGAPSQKDTPNPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRRLLGPILDGASVAATPSTPLATRHPQSPLSADLPDELPVGTENVHRLFTSGKDTEAVETDLDIAQDADALDLEMLAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALEPSLLPRWGSDPRLSCSSPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSPSPEHENFLLFPLSLSFLLTGGPAPGSLQDPSTPLLNLNEPLGLGPSLLSPYSDEDTTQPGGPFQPRAGSAQAD", "length": 669 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-040426-1315", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-040426-1315#orthology", "database": "AGR" }, { "id": "HGNC:15825", "url": "https://alliancegenome.org/gene/HGNC:15825#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB28", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB28" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB28", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB28" } ], "pmid": "" }, { "name": "beta-catenin-TCF complex", "id": "GO:1990907", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990907", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB28", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB28" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB28", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB28" } ], "pmid": "" }, { "name": "neuron apoptotic process", "id": "GO:0051402", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051402", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB28", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB28" } ], "pmid": "" }, { "name": "response to hypoxia", "id": "GO:0001666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001666", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB28", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB28" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB28", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB28" } ], "pmid": "" }, { "name": "cellular response to hypoxia", "id": "GO:0071456", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071456", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB28", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB28" } ], "pmid": "" }, { "name": "response to activity", "id": "GO:0014823", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014823", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB28", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB28" } ], "pmid": "" }, { "name": "erythrocyte development", "id": "GO:0048821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048821", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB28", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB28" } ], "pmid": "" }, { "name": "eye development", "id": "GO:0001654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001654", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB28", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB28" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "protein dimerization activity", "id": "GO:0046983", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046983", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB28", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB28" } ], "pmid": "" }, { "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB28", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB28" } ], "pmid": "" }, { "name": "transcription cis-regulatory region binding", "id": "GO:0000976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000976", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB28", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB28" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB28", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB28" } ], "pmid": "" }, { "name": "beta-catenin binding", "id": "GO:0008013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008013", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB28", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB28" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.agr", "label": "AGR Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 78, 505 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", 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