{ "uniprot_canonical_ac": "A0A0R4IB13-1", "uniprot_ac": "A0A0R4IB13", "uniprot_id": "A0A0R4IB13_DANRE", "mass": { "chemical_mass": 81884.0, "monoisotopic_mass": 81884.0 }, "refseq": { "ac": "NP_001017360", "name": "X-ray repair cross-complementing protein 5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017360" }, "gene_names": [ { "name": "xrcc5", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB13", "id": "A0A0R4IB13" }, { "name": "Ku80", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB13", "id": "A0A0R4IB13" }, { "name": "im:7137560; Ku80; si:ch211-239d11.4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017360", "id": "NP_001017360" }, { "name": "im:7137560", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB13", "id": "A0A0R4IB13" }, { "name": "si:ch211-239d11.4", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB13", "id": "A0A0R4IB13" }, { "name": "xrcc5", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017360", "id": "NP_001017360" } ], "protein_names": [ { "name": "X-ray repair cross-complementing protein 5", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB13/entry#names_and_taxonomy", "id": "A0A0R4IB13" }, { "name": "3.6.4.-", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB13/entry#names_and_taxonomy", "id": "A0A0R4IB13" }, { "name": "DNA binding protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017360", "id": "NP_001017360" }, { "name": "X-ray repair cross-complementing protein 5", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017360", "id": "NP_001017360" } ], "function": [ { "annotation": "##Evidence-Data-START## Transcript exon combination :: AY877316.1, GDQH01005405.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CR339053.18 and CR392344.9. On Jun 13, 2015 this sequence version replaced NP_001017360.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.", "evidence": [ { "database": "RefSeq", "id": "NP_001017360", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017360" } ] }, { "annotation": "Single-stranded DNA-dependent ATP-dependent helicase.", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB13", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB13#function" }, { "database": "UniProtKB", "id": "PIRNR016570", "url": "https://www.uniprot.org/uniprotkb/PIRNR016570#function" } ] } ], "disease": [ { "disease_id": "DOID:1749", "recommended_name": { "id": "DOID:1749", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1749", "name": "squamous cell carcinoma", "description": "A carcinoma that derives_from squamous epithelial cells." }, "synonyms": [ { "id": "DOID:1749", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1749", "name": "epidermoid carcinoma", "description": "" }, { "id": "DOID:1749", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1749", "name": "malignant squamous cell tumor", "description": "" }, { "id": "DOID:1749", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1749", "name": "squamous carcinoma", "description": "" }, { "id": "DOID:1749", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1749", "name": "squamous cell Epithelioma", "description": "" }, { "id": "DOID:1749", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1749", "name": "squamous cell cancer", "description": "" } ], "unlinked_id_list": [ "DOID:3149" ], "evidence": [ { "id": "1749", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1749" } ] }, { "disease_id": "DOID:1993", "recommended_name": { "id": "DOID:1993", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1993", "name": "rectum cancer", "description": "A colorectal cancer that is located_in the rectum." }, "synonyms": [ { "id": "DOID:1993", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1993", "name": "carcinoma of rectum", "description": "" }, { "id": "DOID:1993", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1993", "name": "carcinoma of the rectum", "description": "" }, { "id": "DOID:1993", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1993", "name": "malignant Rectal tumor", "description": "" }, { "id": "DOID:1993", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1993", "name": "malignant neoplasm of rectum", "description": "" }, { "id": "DOID:1993", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1993", "name": "malignant rectum tumor", "description": "" }, { "id": "DOID:1993", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1993", "name": "malignant tumor of rectum", "description": "" }, { "id": "DOID:1993", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1993", "name": "rectal cancer", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "1993", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1993" } ] }, { "disease_id": "DOID:2513", "recommended_name": { "id": "DOID:2513", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2513", "name": "basal cell carcinoma", "description": "A skin carcinoma affecting basal cells." }, "synonyms": [ { "id": "DOID:2513", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2513", "name": "Basal cell cancer", "description": "" }, { "id": "DOID:2513", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2513", "name": "Basal cell carcinoma of skin", "description": "" }, { "id": "DOID:2513", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2513", "name": "Basal cell neoplasm", "description": "" }, { "id": "DOID:2513", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2513", "name": "Basal cell tumor", "description": "" }, { "id": "DOID:2513", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2513", "name": "Epithelioma basal cell", "description": "" }, { "id": "DOID:2513", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2513", "name": "Rodent ulcer", "description": "" }, { "id": "DOID:2513", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2513", "name": "malignant Basal cell neoplasm", "description": "" }, { "id": "DOID:2513", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2513", "name": "malignant basal cell tumor", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "2513", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2513" } ] }, { "disease_id": "DOID:3083", "recommended_name": { "id": "DOID:3083", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3083", "name": "chronic obstructive pulmonary disease", "description": "An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both." }, "synonyms": [ { "id": "DOID:3083", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3083", "name": "COLD", "description": "" }, { "id": "DOID:3083", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3083", "name": "COPD", "description": "" }, { "id": "DOID:3083", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3083", "name": "chronic obstructive airway disease", "description": "" }, { "id": "DOID:3083", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3083", "name": "chronic obstructive lung disease", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "chronic obstructive pulmonary disease", "description": "A chronic and progressive lung disorder characterized by the loss of elasticity of the bronchial tree and the air sacs, destruction of the air sacs wall, thickening of the bronchial wall, and mucous accumulation in the bronchial tree. The pathologic changes result in the disruption of the air flow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough, and chest tightness. The two main types of chronic obstructive pulmonary disease are chronic obstructive bronchitis and emphysema." }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "COLD", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "COPD", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "COPD, chronic obstructive pulmonary disease", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "chronic obstructive airway disease", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "chronic obstructive airways disease", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "chronic obstructive lung disease", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "chronic obstructive pulmonary disease (COPD)", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "chronic obstructive pulmonary disease, (COPD)", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "cold", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "cold (chronic obstructive lung disease)", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "disease (COPD), chronic obstructive", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "obstructive lung disease, chronic", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "obstructive pulmonary disease (COPD), chronic", "description": "" }, { "id": "MONDO:0005002", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005002", "name": "pulmonary disease (COPD), chronic obstructive", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "3083", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3083" } ] }, { "disease_id": "DOID:9538", "recommended_name": { "id": "DOID:9538", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9538", "name": "multiple myeloma", "description": "A myeloid neoplasm that is located_in the plasma cells in bone marrow." }, "synonyms": [ { "id": "DOID:9538", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9538", "name": "myeloma", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "plasma cell myeloma", "description": "A bone marrow-based plasma cell neoplasm characterized by a serum monoclonal protein and skeletal destruction with osteolytic lesions, pathological fractures, bone pain, hypercalcemia, and anemia. Clinical variants include non-secretory myeloma, smoldering myeloma, indolent myeloma, and plasma cell leukemia. (WHO, 2001)" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "Kahler disease", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "Kahler's disease", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "Multiple Myeloma", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "medullary plasmacytoma", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "multiple myeloma", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "multiple myeloma, resistance to, Somatic mutation", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "multiple myeloma, susceptibility to, Somatic mutation", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "multiple myeloma/plasma cell myeloma", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "myeloid neoplasm of plasma cell", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "myeloma", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "myeloma, multiple", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "myeloma, plasma cell, malignant", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "myelomatosis", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "plasma cell myeloid neoplasm", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "plasma cell myeloma", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "Al amyloidosis", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "amyloidosis, systemic", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "myeloma - multiple", "description": "" }, { "id": "MIM:254500", "resource": "MIM", "url": "https://www.omim.org/entry/254500", "name": "Multiple myeloma", "description": "Multiple myeloma" } ], "unlinked_id_list": [], "evidence": [ { "id": "9538", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9538" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Danio rerio", "taxid": 7955, "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB13", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB13" } ], "common_name": "Zebrafish", "glygen_name": "Zebrafish", "reference_species": "Danio rerio [7955]" } ], "gene": [ { "name": "xrcc5", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB13", "locus": {} } ], "crossref": [ { "id": "ZFIN:ZDB-GENE-041008-108", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-041008-108", "database": "AGR", "categories": [ "Protein Classification" ] }, { "id": "ENSDARG00000099298", "url": "https://bgee.org/?page=gene&gene_id=ENSDARG00000099298", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00873", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00873", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "449848", "url": "https://www.ncbi.nlm.nih.gov/gene/449848", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002035", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002035", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005160", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005160", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005161", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005161", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006164", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006164", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014893", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014893", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016194", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016194", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024193", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024193", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036465", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036465", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036494", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036494", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dre:449848", "url": "https://www.genome.jp/dbget-bin/www_bget?dre:449848", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "WAMQYVW", "url": "https://omabrowser.org/oma/group/WAMQYVW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A0R4IB13", "url": "https://www.orthodb.org/?gene=A0A0R4IB13", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12604", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12604", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12604:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12604:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02735", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02735", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF03730", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03730", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF03731", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03731", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF08785", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08785", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "NP_001017360", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017360", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A0R4IB13", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB13", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0R4IB13-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB13-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "ZDB-GENE-041008-108", "url": "https://zfin.org/ZDB-GENE-041008-108", "database": "ZFIN", "categories": [ "Protein", "Organism-specific" ] } ], "sequence": { "sequence": "MARAAKSALVLCMDVGFSMSNSGPGQEPPFEQAKKVIQKFVQRQVFAENKDEIGLVLFGTDGTKNPLANDGQYENITVHRHLMIPDFELLEEIERELQPGGQQADWLDALVVCMDLLQNETMGKKYDRLNIALLTDLNIQTSEDQLDIIIQNLKKAGITLQFFLPFPVDVEDEAGGGGDAAGPSAPPSRPGKGLSRQQTQGLEMVKHIMSSLEDEDGLEEVYTFSDALEKLSIFKRIERRPMAWPCQLTIGSSLSIRIVGYKAVTEEKVKKSWTIVDAQSHQRDDVKRETVYCLNDDDETEVQKDDTIQGYRYGSDIVPFSKVDEEQMKYKHDGKCFSVLGFTKQELIPRHQFMGSQVVKVFAPRDDEHAAVALSSLIRALDGLKMAAIVRYAYDRRSNPQVGAAFPCIKKKYECLLYVQLPYMEDLRQFTFPMLENNKKFMPSGSQLSAVDALIDSMMLMEKDENGESVEIFKVNHIPNPQFQRLFQCLHHRGVNPDDPLPPVDPWLKRVLERPQAVSARCQAPLRDVKTSFPLKVVVKKKEQKTSADVFGSSADEPDAKKVKVNEETEFNLAEITEGNITSVGSVNPARDFCTLIRQKTVSFDQACQQLTHRIEQLLGNRSTEYYTKSIACIQAFRDQSVLSGNAELFNSYLQSLKRSIADRSLQDFWNLLAQDALTLISKDEVEASTISKQEANQFLSFEQKQEVEVAPAQDDTGDVDDLLDMM", "length": 727, "header": "tr|A0A0R4IB13-1|A0A0R4IB13_DANRE Isoform 1 of X-ray repair cross-complementing protein 5 OS=Danio rerio OX=7955 GN=xrcc5 PE=1 SV=1 CANONICAL=A0A0R4IB13-1" }, "isoforms": [ { "isoform_ac": "A0A0R4IB13-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB13/entry#A0A0R4IB13-1", "sequence": { "sequence": "MARAAKSALVLCMDVGFSMSNSGPGQEPPFEQAKKVIQKFVQRQVFAENKDEIGLVLFGTDGTKNPLANDGQYENITVHRHLMIPDFELLEEIERELQPGGQQADWLDALVVCMDLLQNETMGKKYDRLNIALLTDLNIQTSEDQLDIIIQNLKKAGITLQFFLPFPVDVEDEAGGGGDAAGPSAPPSRPGKGLSRQQTQGLEMVKHIMSSLEDEDGLEEVYTFSDALEKLSIFKRIERRPMAWPCQLTIGSSLSIRIVGYKAVTEEKVKKSWTIVDAQSHQRDDVKRETVYCLNDDDETEVQKDDTIQGYRYGSDIVPFSKVDEEQMKYKHDGKCFSVLGFTKQELIPRHQFMGSQVVKVFAPRDDEHAAVALSSLIRALDGLKMAAIVRYAYDRRSNPQVGAAFPCIKKKYECLLYVQLPYMEDLRQFTFPMLENNKKFMPSGSQLSAVDALIDSMMLMEKDENGESVEIFKVNHIPNPQFQRLFQCLHHRGVNPDDPLPPVDPWLKRVLERPQAVSARCQAPLRDVKTSFPLKVVVKKKEQKTSADVFGSSADEPDAKKVKVNEETEFNLAEITEGNITSVGSVNPARDFCTLIRQKTVSFDQACQQLTHRIEQLLGNRSTEYYTKSIACIQAFRDQSVLSGNAELFNSYLQSLKRSIADRSLQDFWNLLAQDALTLISKDEVEASTISKQEANQFLSFEQKQEVEVAPAQDDTGDVDDLLDMM", "length": 727, "header": "tr|A0A0R4IB13-1|A0A0R4IB13_DANRE Isoform 1 of X-ray repair cross-complementing protein 5 OS=Danio rerio OX=7955 GN=xrcc5 PE=1 SV=1 CANONICAL=A0A0R4IB13-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "DNA damage response and Ku80 function in the vertebrate embryo.", "journal": "Nucleic Acids Res.", "date": "2005", "authors": "Bladen Catherine L, Lam Wai K, Dynan William S, Kozlowski David J", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB13", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB13" } ], "reference": [ { "type": "PubMed", "id": "15914672", "url": "https://glygen.org/publication/PubMed/15914672" } ] }, { "title": "Quantification of ionizing radiation-induced cell death in situ in a vertebrate embryo.", "journal": "Radiat. Res.", "date": "2007", "authors": "Bladen Catherine L, Flowers Melody A, Miyake Katsuya, Podolsky Robert H, Barrett John T, Kozlowski David J, Dynan William S", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB13", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB13" } ], "reference": [ { "type": "PubMed", "id": "17638406", "url": "https://glygen.org/publication/PubMed/17638406" } ] }, { "title": "Time-course expression of DNA repair-related genes in hepatocytes of zebrafish (Danio rerio) after UV-B exposure.", "journal": "Photochem. Photobiol.", "date": "2009", "authors": "Sandrini Juliana Z, Trindade Gilma S, Nery Luiz Eduardo M, Marins Luis F", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB13", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB13" } ], "reference": [ { "type": "PubMed", "id": "18764902", "url": "https://glygen.org/publication/PubMed/18764902" } ] }, { "title": "Reactive oxygen species generation and expression of DNA repair-related genes after copper exposure in zebrafish (Danio rerio) ZFL cells.", "journal": "Aquat. Toxicol.", "date": "2009", "authors": "Sandrini Juliana Zomer, Bianchini Adalto, Trindade Gilma Santos, Nery Luiz Eduardo Maia, Marins Luis Fernando Fernandes", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB13", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB13" } ], "reference": [ { "type": "PubMed", "id": "19328561", "url": "https://glygen.org/publication/PubMed/19328561" } ] }, { "title": "Zebrafish have a competent p53-dependent nucleotide excision repair pathway to resolve ultraviolet B-induced DNA damage in the skin.", "journal": "Zebrafish", "date": "2009", "authors": "Zeng Zhiqiang, Richardson Jennifer, Verduzco Daniel, Mitchell David L, Patton E Elizabeth", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB13", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB13" } ], "reference": [ { "type": "PubMed", "id": "20047468", "url": "https://glygen.org/publication/PubMed/20047468" } ] }, { "title": "The zebrafish reference genome sequence and its relationship to the human genome.", "journal": "Nature", "date": "2013", "authors": "Howe Kerstin, Clark Matthew D, Torroja Carlos F, Torrance James, Berthelot Camille, Muffato Matthieu, Collins John E, Humphray Sean, McLaren Karen, Matthews Lucy, McLaren Stuart, Sealy Ian, Caccamo Mario, Churcher Carol, Scott Carol, Barrett Jeffrey C, Koch Romke, Rauch Gerd-J\u00f6rg, White Simon, Chow William, Kilian Britt, Quintais Leonor T, Guerra-Assun\u00e7\u00e3o Jos\u00e9 A, Zhou Yi, Gu Yong, Yen Jennifer, Vogel Jan-Hinnerk, Eyre Tina, Redmond Seth, Banerjee Ruby, Chi Jianxiang, Fu Beiyuan, Langley Elizabeth, Maguire Sean F, Laird Gavin K, Lloyd David, Kenyon Emma, Donaldson Sarah, Sehra Harminder, Almeida-King Jeff, Loveland Jane, Trevanion Stephen, Jones Matt, Quail Mike, Willey Dave, Hunt Adrienne, Burton John, Sims Sarah, McLay Kirsten, Plumb Bob, Davis Joy, Clee Chris, Oliver Karen, Clark Richard, Riddle Clare, Elliot David, Eliott David, Threadgold Glen, Harden Glenn, Ware Darren, Begum Sharmin, Mortimore Beverley, Mortimer Beverly, Kerry Giselle, Heath Paul, Phillimore Benjamin, Tracey Alan, Corby Nicole, Dunn Matthew, Johnson Christopher, Wood Jonathan, Clark Susan, Pelan Sarah, Griffiths Guy, Smith Michelle, Glithero Rebecca, Howden Philip, Barker Nicholas, Lloyd Christine, Stevens Christopher, Harley Joanna, Holt Karen, Panagiotidis Georgios, Lovell Jamieson, Beasley Helen, Henderson Carl, Gordon Daria, Auger Katherine, Wright Deborah, Collins Joanna, Raisen Claire, Dyer Lauren, Leung Kenric, Robertson Lauren, Ambridge Kirsty, Leongamornlert Daniel, McGuire Sarah, Gilderthorp Ruth, Griffiths Coline, Manthravadi Deepa, Nichol Sarah, Barker Gary, Whitehead Siobhan, Kay Michael, Brown Jacqueline, Murnane Clare, Gray Emma, Humphries Matthew, Sycamore Neil, Barker Darren, Saunders David, Wallis Justene, Babbage Anne, Hammond Sian, Mashreghi-Mohammadi Maryam, Barr Lucy, Martin Sancha, Wray Paul, Ellington Andrew, Matthews Nicholas, Ellwood Matthew, Woodmansey Rebecca, Clark Graham, Cooper James D, Cooper James, Tromans Anthony, Grafham Darren, Skuce Carl, Pandian Richard, Andrews Robert, Harrison Elliot, Kimberley Andrew, Garnett Jane, Fosker Nigel, Hall Rebekah, Garner Patrick, Kelly Daniel, Bird Christine, Palmer Sophie, Gehring Ines, Berger Andrea, Dooley Christopher M, Ersan-\u00dcr\u00fcn Z\u00fcbeyde, Eser Cigdem, Geiger Horst, Geisler Maria, Karotki Lena, Kirn Anette, Konantz Judith, Konantz Martina, Oberl\u00e4nder Martina, Rudolph-Geiger Silke, Teucke Mathias, Lanz Christa, Raddatz G\u00fcnter, Osoegawa Kazutoyo, Zhu Baoli, Rapp Amanda, Widaa Sara, Langford Cordelia, Yang Fengtang, Schuster Stephan C, Carter Nigel P, Harrow Jennifer, Ning Zemin, Herrero Javier, Searle Steve M J, Enright Anton, Geisler Robert, Plasterk Ronald H A, Lee Charles, Westerfield Monte, de Jong Pieter J, Zon Leonard I, Postlethwait John H, N\u00fcsslein-Volhard Christiane, Hubbard Tim J P, Roest Crollius Hugues, Rogers Jane, Stemple Derek L", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB13", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB13" } ], "reference": [ { "type": "PubMed", "id": "23594743", "url": "https://glygen.org/publication/PubMed/23594743" } ] }, { "title": "Knock-In Strategy for Editing Human and Zebrafish Mitochondrial DNA Using Mito-CRISPR/Cas9 System.", "journal": "ACS Synth. Biol.", "date": "2019", "authors": "Bian Wan-Ping, Chen Yan-Ling, Luo Juan-Juan, Wang Chao, Xie Shao-Lin, Pei De-Sheng", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB13", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB13" } ], "reference": [ { "type": "PubMed", "id": "30955321", "url": "https://glygen.org/publication/PubMed/30955321" } ] }, { "title": "Strategies for genetic inactivation of long noncoding RNAs in zebrafish.", "journal": "RNA", "date": "2019", "authors": "Lavalou Perrine, Eckert Helene, Damy Louise, Constanty Florian, Majello Sara, Bitetti Angelo, Graindorge Antoine, Shkumatava Alena", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB13", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB13" } ], "reference": [ { "type": "PubMed", "id": "31043511", "url": "https://glygen.org/publication/PubMed/31043511" } ] }, { "title": "Bis(2-ethylhexyl) phthalate induces DNA strand breaks and gene expression alterations in larval zebrafish Danio rerio.", "journal": "Toxicol Ind Health", "date": "2019", "authors": "Boran Halis, Terzi Serap", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB13", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB13" } ], "reference": [ { "type": "PubMed", "id": "31462198", "url": "https://glygen.org/publication/PubMed/31462198" } ] }, { "title": "Chaga mushroom (Inonotus obliquus) polysaccharides exhibit genoprotective effects in UVB-exposed embryonic zebrafish (Danio rerio) through coordinated expression of DNA repair genes.", "journal": "Heliyon", "date": "2021", "authors": "Eid Jehane Ibrahim, Al-Tuwaijri Majdah Mohammad, Mohanty Swabhiman, Das Biswadeep", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB13", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB13" } ], "reference": [ { "type": "PubMed", "id": "33598573", "url": "https://glygen.org/publication/PubMed/33598573" } ] }, { "title": "Parp1 promotes sleep, which enhances DNA repair in neurons.", "journal": "Mol. Cell", "date": "2021", "authors": "Zada D, Sela Y, Matosevich N, Monsonego A, Lerer-Goldshtein T, Nir Y, Appelbaum L", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB13", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB13" } ], "reference": [ { "type": "PubMed", "id": "34798058", "url": "https://glygen.org/publication/PubMed/34798058" } ] } ], "pathway": [ { "id": "dre:449848", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?dre:449848", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A286ZIV3-1", "protein_name": "X-ray repair cross-complementing protein 5", "gene_name": "XRCC5", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MLGLQSSASEQGMESAHAQSFDAQFPRPSQAPREVVLPASLQRQGRRNRVSAPRFPARKRLLRRWRASNMARWGNKAAVVLCVDVGFAMSNSFPGEESPFELAKKVITMFVQRQVFAESKDEIALVLFGTDGTENALAGKDQYQNITVHRHLKLPDFDLLEDIESKIQPGSQQADFLDALIVCMDLIQQETIGKKFEKRHIEVFTDLSSPFSKDQLDIIIHNLKKSGISLQFFLPFPVGKEDGTGDRGDSSLRPDHHGPSFPLKGITEQQKEGIQMVKKVMMSLEGEDGLDEIYSFSESLRQLCIFKKIEKHSMPWPCQLTIGSNLSIRIVAYKSILQEKVKQSWTAVDARTLKKEDIRKETVYCLNDDDETEVPKEDTIQGFRYGSDIIPFSKVDEEQMKYKSEGKCFSVLGFCRSSQVHRKYFMGNQVLKVFAAKDDEAAAVALSSLIHALDELDMVAVVRYAYDKKANPQVGVAFPYIKDAYECLVYIQLPFMEDLRQYMFSSLKNNKKCTPTEAQLSAVDSLIDSMCLVKKDEEEGTIEDLFPTVKIPNPQFQRLFQCLLHRALHPQEPLPPIQQHILNMLDPPTEVTAKCQIPLSKIKTLFPLTEVIKKKDQVTAQDIFQDNHEEAPSSKKLKTEEEEAHFRISSLAEGSVTRVGSVTPAENFRVLVRQKKASFEEASHQLISHIEQFLDTNETPYFMKSMDCIKVFREEAIQFSEEQRFNNFLRALREKVEMKQLNHFWEIVIQDGMTLITKDEASGSSVTVEEAQKFLEPEENPNEDTAAMLEEGGDVDDLVSTHYIPGVVMIDPAEAVNTATKPAYHRLASYVCFNF", "length": 835 }, "evidence": [ { "id": "A0A0R4IB13", "url": "https://omabrowser.org/oma/group/A0A0R4IB13/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A7MBA7-1", "protein_name": "X-ray repair cross-complementing protein 5", "gene_name": "XRCC5", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MARSWDKAAVVLCMDVGLAMSNSFPGEESPFELAKKVMTMFVQRQVFAENKDEVALVLFGTDGTKNALAAGDQYQNITVHRHLMRPDFDLLEDIESKIQPGSQQADLLDALIVCMDLIQEETLGKKFEKRHIEVFTDLSSPFSRDQLDIIIHNLKKSGISLQFFLPFPIGKQGGTGDRGDGSLLSDHHGPSFPPKGITEQQKEGIQMVKKVMMSLEGEDGLEEIYSFSEALRQLCVFKKTERRSMPWSCQLTIGSNLSIKIVAYKSITQEKVKKCWTVVDARTLKKEAIQKETVYCLNDDDETEVSKEDTIQGFRYGSDIIPFSKVDEEQMKYKSEGKCFSVLGFCRSSQVHMKYFMGNQVLKVFAAKDDEAAAVALSSLIHALDELDMVAVVRYVYNEKTNPQVGVAFPLIKDAYECLVYIQLPFMEDLRQYMFPSLKNNRKCTPTEAQLSAVDALIDSMSLVQKDEEEGTIEDLFPTSKIPNPQFQRLFQCLLHRALHPQEPLPPIQQHILSMLDPPTEVTAKCQVPLSKIKTLFPLTEVIKKKNQVTGQDIFQDNHEEGPTCKKLKTEEEEAHFSVSSLAEGSVTCVGSVNPAENFRVLVRQKKATFEEASHQLINHIEQFLDTNETLYFMKSMDCIKAFREEAIQFSEEQRFNNFLKALREKVEVKQLNHFWEIVVHDGVTLITKDEAPGSSVTTEEAKKFLAPKENANADSAAAFEEGGDVDDLLELI", "length": 733 }, "evidence": [ { "id": "A0A0R4IB13", "url": "https://omabrowser.org/oma/group/A0A0R4IB13/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "G3H3Z2-1", "protein_name": "X-ray repair cross-complementing protein 5", "gene_name": "", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MAWSANKAAVVLCMDVGVAMGNSFPGEESSFEQAKKVMTMFVQRQVFSESKDEIALVLFGTDNTNNALASEDQYQNITVHRHLMLPDFDLLEDIESKIQLGSRQADILDALIVCMDLIQRETIGKKFEKKHIEVFTDLSSPFSQDQLDVIICNLKKSGISLQFFLPFPISKNDETGDRGDGDLGLDHCGPSFPQKGITEQQKEGICMVERVMVSLEGEDGLDEIYSFSESLRQLCVFKKIERRSMPWSCQLTIGPDLSIKIVAYKSIVQEKVKKSWIVVDARTLKKEDIRKETVYCLNDDDETEVSKEDTIQGFRYGSDIIPFSKVDEEQMKYKSEGKCFSVLGFCRSSQVHRRFFMGYQVLKVFAAKDDEAAAVALSSLIHALDELNMVAIVRYAYDKRANPQVGVAFPYIKDSYECLVYVQLPFMEDLRQYMFSSLKNNKKCTPTEAQLSAIDDLIESMSLVKKSEEEDTIEDLFPTSKIPNPEFQRFFQCLLHRVLHPQERLPPIQQHILNMLNLPTEMKAKCEIPLSKVRTLFPLTEAVKKKDQVTAQDIFQDIHEEGPAAKKCKTEKEEGHISISSVAEGNVTKVGSVNPVESFRVLVRQKIASFEQASLQLISHIEQFLDTNETLYFMKSMECIKAFREEAIQFSEEQRFNSFLEALREKVEIKQLNHFWEIVVQDGVTLITKDEGSGSSVTTEEATKFLAPKDKAKEDAAGLEEGGDVDDLLDMI", "length": 732 }, "evidence": [ { "id": "A0A0R4IB13", "url": "https://omabrowser.org/oma/group/A0A0R4IB13/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "G3V817-1", "protein_name": "X-ray repair cross-complementing protein 5", "gene_name": "Xrcc5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAWSGNKAAVVLCMDVGVAMGNSFPGEESPLEQAKKVMTMFVQRQVFSESKDEIALVLYGTESTDNALAGKDQYQNITVHRHLMLPDFDLLEDIGNKIQPSSQQADFLDALIVCMDLIQRETIGKKFGKKHIEVFTDLSSPFSQDQLDIIICNLKKSSISLQFFLPFPIDKNGEPGETEDHDSSFDHCAPSFPQKGLTEQQKEGIHMVTRVMLSLEGKDGLDEIYSFSESLQQLCIFKKIERRSLPWPCQLTIGPNLSIRIVAYKSIVQEKFKKSWVVVDARTLKKEDIQKETVYCLNDDDETEVSKEDTIQGFRYGSDIIPFSKVDEEQMKYKSEGKCFSVLGFCKSSQVHRRFFMGHQVLKVFAAKDDEAAAVALSSLVHALDELNMVAIVRYAYDKRANPQVGVAFPFIKDAYECLVYVQLPFMEDLRQYMFSSLKNNKKCTPTEAQLSAIDDLIDSMSLVKKNEEEDIIEDLFPTSKIPNPEFQRLYQCLLHRALHLQERLPPIQQHILNMLDPPTEMKAKCEIPLSKVKTLFPLTEVVKKKDQVTAQDVFQDNIEEGPAAKKYKTEKEEGHISISSLAEGNVTKVGSVNPVENFRVLVRQKIASFEEASLQLMSHIEQFLDTNETLYFMKSMDCIKALREEAIQFSEEQRFNSFLEGLREKVEIKQLNHFWEIVVQDGITLITKDESPGSSVTAEEATKFLTPKDKAKEDTTGLEEGGDVDDLLDMI", "length": 732 }, "evidence": [ { "id": "MGI:104517", "url": "https://alliancegenome.org/gene/MGI:104517#orthology", "database": "AGR" }, { "id": "HGNC:12833", "url": "https://alliancegenome.org/gene/HGNC:12833#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P13010-1", "protein_name": "X-ray repair cross-complementing protein 5", "gene_name": "XRCC5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVRSGNKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAENKDEIALVLFGTDGTDNPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQADFLDALIVSMDVIQHETIGKKFEKRHIEIFTDLSSRFSKSQLDIIIHSLKKCDISLQFFLPFSLGKEDGSGDRGDGPFRLGGHGPSFPLKGITEQQKEGLEIVKMVMISLEGEDGLDEIYSFSESLRKLCVFKKIERHSIHWPCRLTIGSNLSIRIAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDDDETEVLKEDIIQGFRYGSDIVPFSKVDEEQMKYKSEGKCFSVLGFCKSSQVQRRFFMGNQVLKVFAARDDEAAAVALSSLIHALDDLDMVAIVRYAYDKRANPQVGVAFPHIKHNYECLVYVQLPFMEDLRQYMFSSLKNSKKYAPTEAQLNAVDALIDSMSLAKKDEKTDTLEDLFPTTKIPNPRFQRLFQCLLHRALHPREPLPPIQQHIWNMLNPPAEVTTKSQIPLSKIKTLFPLIEAKKKDQVTAQEIFQDNHEDGPTAKKLKTEQGGAHFSVSSLAEGSVTSVGSVNPAENFRVLVKQKKASFEEASNQLINHIEQFLDTNETPYFMKSIDCIRAFREEAIKFSEEQRFNNFLKALQEKVEIKQLNHFWEIVVQDGITLITKEEASGSSVTAEEAKKFLAPKDKPSGDTAAVFEEGGDVDDLLDMI", "length": 732 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-041008-108", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-041008-108#orthology", "database": "AGR" }, { "id": "MGI:104517", "url": "https://alliancegenome.org/gene/MGI:104517#orthology", "database": "AGR" }, { "id": "HGNC:12833", "url": "https://alliancegenome.org/gene/HGNC:12833#orthology", "database": "AGR" }, { "id": "A0A0R4IB13", "url": "https://omabrowser.org/oma/group/A0A0R4IB13/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P27641-1", "protein_name": "X-ray repair cross-complementing protein 5", "gene_name": "Xrcc5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAWSGNKAAVVLCVDVGVAMGNSFPGEESPIEQAKKVMTMFVQRQVFSESKDEIALVLYGTDGTDNALAGKDQYQNITVCRHLMLPDFDLLEDIGNKIQPSSQQADFLDALIVCMDLIQRETIGKKFGKKHIEVFTDLSSPFSQDQLDVIICNLKKSGISLQFFLPFPIDKNGEPGERGDLDSGLDHLKPSFPQKGLTEQQKEGIRMVTRVMLSLEGEDGLDEIYSFSESLRQLCVFKKIERRSMPWPCQLTIGPNLSIKIVAYKSIVQEKFKKSWVVVDARTLKKEDIQKETVYCLNDDDETEVSKEDTIQGYRYGSDIIPFSKVDEEQMKYKSEGKCFSVLGFCKSSQVHRRFFMGHQVLKVFAAKDDEAAAVALSSLVHALDELNMVAIVRYAYDKRSNPQVGVAFPYIKDAYECLVYVQLPFMEDLRQYMFSSLKNNKKCTPTEAQLSAIDDLIDSMSLVKKNEEEDIVEDLFPTSKIPNPEFQRLYQCLLHRALHLQERLPPIQQHILNMLDPPTEMKAKCESPLSKVKTLFPLTEVIKKKNQVTAQDVFQDNHEEGPAAKKYKTEKEEDHISISSLAEGNITKVGSVNPVENFRFLVRQKIASFEEASLQLISHIEQFLDTNETLYFMKSMDCIKAFREEAIQFSEEQRFNSFLEALREKVEIKQLNHFWEIVVQDGVTLITKDEGPGSSITAEEATKFLAPKDKAKEDTTGPEEAGDVDDLLDMI", "length": 732 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-041008-108", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-041008-108#orthology", "database": "AGR" }, { "id": "MGI:104517", "url": "https://alliancegenome.org/gene/MGI:104517#orthology", "database": "AGR" }, { "id": "HGNC:12833", "url": "https://alliancegenome.org/gene/HGNC:12833#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q04437-1", "protein_name": "ATP-dependent DNA helicase II subunit 2", "gene_name": "YKU80", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSSESTTFIVDVSPSMMKNNNVSKSMAYLEYTLLNKSKKSRKTDWISCYLANCPVSENSQEIPNVFQIQSFLAPVTTTATIGFIKRLKQYCDQHSHDSSNEGLQSMIQCLLVVSLDIKQQFQARKILKQIVVFTDNLDDLDITDEEIDLLTEELSTRIILIDCGKDTQEERKKSNWLKLVEAIPNSRIYNMNELLVEITSPATSVVKPVRVFSGELRLGADILSTQTSNPSGSMQDENCLCIKVEAFPATKAVSGLNRKTAVEVEDSQKKERYVGVKSIIEYEIHNEGNKKNVSEDDQSGSSYIPVTISKDSVTKAYRYGADYVVLPSVLVDQTVYESFPGLDLRGFLNREALPRYFLTSESSFITADTRLGCQSDLMAFSALVDVMLENRKIAVARYVSKKDSEVNMCALCPVLIEHSNINSEKKFVKSLTLCRLPFAEDERVTDFPKLLDRTTTSGVPLKKETDGHQIDELMEQFVDSMDTDELPEIPLGNYYQPIGEVTTDTTLPLPSLNKDQEENKKDPLRIPTVFVYRQQQVLLEWIHQLMINDSREFEIPELPDSLKNKISPYTHKKFDSTKLVEVLGIKKVDKLKLDSELKTELEREKIPDLETLLKRGEQHSRGSPNNSNN", "length": 629 }, "evidence": [ { "id": "MGI:104517", "url": "https://alliancegenome.org/gene/MGI:104517#orthology", "database": "AGR" }, { "id": "HGNC:12833", "url": "https://alliancegenome.org/gene/HGNC:12833#orthology", "database": "AGR" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q54LY5-1", "protein_name": "X-ray repair cross-complementing protein 5", "gene_name": "ku80", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MTTTIPLKEAVVVILDIGLGMTSKDSDGTTTTTSSIEDALRSVTLLYQQKLIYGKKDQLGLVLIGTKGTKNNLQDDGYQHITVVSDIEEPSIETLKYLENLAPGESKGDVIDSLIVAMDMLIRKTENKKYQKRIFLVTNARDPINTEDLSIVRDQFKKIDVKLNIIGVDFLEEIEENNMDTSNNNKNKSLKEKNEIFLREFAESVDGVLVPVKQALEMMSFFRSQSVMTRTSFRGALEITPELKIPVWGYLKMKQQLLPSLKKISSIAQQQIEQQQQQQQQQNKNKNNEDNEDNEEGKPNITLDVNQEVSYYSITDPDNEILKPDLLKGYKYGKSLIPFSKIDEDQLKYSSSKCLKVVGFTDRKSIPIYYNMGNTEVFVSQPGDKQSEEALSSFIHALVETDQVMVVRYVKTMNGSPYLGYMIPHVKSDYVCLYYNHLPLADDIRQYQFPPISPKNPLTRKSNIPNAEQLEATQQLIDSMDLMKSEFDEDGDPIQMLKPRFTYNPLLQHFYQCLHHRSLHPNTQIPKLDPIIAEYINPDQIIMNKSKQSIKNFADKFPLTKTTVFSKTPAISGGNTNGTTSNTNNTMIGGVKYHWKDGMLIGEEINLDSYVTDDGSEAKKRKVNDFSEFSLDKLVSGYVTEVGTINPVQNFKDMLNRRDMDLVDKAITLMKERILQLVNDSLRDQYYQKAFECIKELRVGCIRESEAEQFNGFLKDMRSLFQSKKRDDFWQYITADVTSILGEKSINLITQDECDSSEVTQEELDQFLDKKVKQFNPPPITNVNTDSVDDLFDQIE", "length": 796 }, "evidence": [ { "id": "A0A0R4IB13", "url": "https://omabrowser.org/oma/group/A0A0R4IB13/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9FQ09-1", "protein_name": "ATP-dependent DNA helicase 2 subunit KU80", "gene_name": "KU80", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MARNREGLVLVLDVGPAMRSVLPDVEKACSMLLQKKLIYNKYDEVGIVVFGTEETGNELAREIGGYENVTVLRNIRVVDELAAEHVKQLPRGTVAGDFLDALIVGMDMLIKMYGNAHKGKKRMCLITNAACPTKDPFEGTKDDQVSTIAMKMAAEGIKMESIVMRSNLSGDAHERVIEENDHLLTLFSSNAIAKTVNVDSPLSLLGSLKTRRVAPVTLFRGDLEINPTMKIKVWVYKKVAEERLPTLKMYSDKAPPTDKFAKHEVKVDYDYKVTAESTEVIAPEERIKGFRYGPQVIPISPDQIETLKFKTDKGMKLLGFTEASNILRHYYMKDVNIVVPDPSKEKSVLAVSAIAREMKETNKVAIVRCVWRNGQGNVVVGVLTPNVSERDDTPDSFYFNVLPFAEDVREFPFPSFNKLPSSWKPDEQQQAVADNLVKMLDLAPSAEEEVLKPDLTPNPVLQRFYEYLELKSKSTDATLPPMDGTFKRLMEQDPELSSNNKSIMDTFRGSFEVKENPKLKKASKRLLRDKPSGSDDEDNRMITYDAKENKIDIVGDANPIQDFEAMISRRDKTDWTEKAITQMKNLIMKLVENCTDEGDKALECVLALRKGCVLEQEPKQFNEFLNHLFKLCQERNLSHLLEHFMSKKITLIPKSEAADSDIVDENAGDFIVKQESMLES", "length": 680 }, "evidence": [ { "id": "A0A0R4IB13", "url": "https://omabrowser.org/oma/group/A0A0R4IB13/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q9I7M8-1", "protein_name": "ATP-dependent DNA helicase II subunit 2", "gene_name": "Ku80", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MASNKECLIIVLDVRTCAAEEVKLKSAKCVAEILKDKIVCDRKDYVSFVLVGCDTDEIKTEDASHPNVLPFGEPRLCSWQLLLEFFQFVNKTACEDGEWLNGLQAALELQNVATTLRVARRRILLLFDFNDFPQDYEKFNEITDELLGENIELIVGTHNIAYIDNAITSQPQAIFNFSRKCGPDELNNQKYALSLVPRCNATLCSFKEALHTVFKVTNRRPWVWNAKLNIGSKISISLQGIIAMKNQTPVKLVKVWAEKDEIVIRETRHYIKGTEITPLPENLITGYMLGGTPVPYDEAVLEPKEPHPPGLHFFGFIKRNAVPDEYFCGESLYLLVHQKHNQSAAVKLDALVRALVSSDRAILCWKIYSTKFNRPQMVVLLPRLADDTHPATLYMLEVSYTSQHHFWDFPALRTTKTECSEEQLNAIDQLIDSTDLECTLRDTQQPRPWAQNDLLPFDALPSIFEQNVMDILERKVIYDNDKEDKMLKDKNFADVFWRVPDPLEEKSKRAAAIVKKLFPLRYSRAWQEKLLAKEQAENGVAVKSEPAEKEIPLPSDGVGLIDPISDFRRVLASVHTISNATERDARFQALAADTRVVIITLLQRRKQNIGQLGELITLYRQSCIDFNTFLEYDKFAEELKKIALAKNRSEFWQDVMVDKQLGPLVLGEPTLDDELALKAYYTIENWVESGANDMEDVEM", "length": 699 }, "evidence": [ { "id": "MGI:104517", "url": "https://alliancegenome.org/gene/MGI:104517#orthology", "database": "AGR" }, { "id": "HGNC:12833", "url": "https://alliancegenome.org/gene/HGNC:12833#orthology", "database": "AGR" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB13", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB13" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB13", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB13" } ], "pmid": "" }, { "name": "damaged DNA binding", "id": "GO:0003684", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003684", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB13", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB13" } ], "pmid": "" }, { "name": "telomeric DNA binding", "id": "GO:0042162", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042162", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB13", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB13" } ], "pmid": "" }, { "name": "DNA helicase activity", "id": "GO:0003678", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003678", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB13", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB13" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "DNA recombination", "id": "GO:0006310", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006310", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB13", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB13" } ], "pmid": "" }, { "name": "negative regulation of apoptotic process", "id": "GO:0043066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB13", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB13" } ], "pmid": "" }, { "name": "telomere maintenance", "id": "GO:0000723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000723", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB13", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB13" } ], "pmid": "" }, { "name": "intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator", "id": "GO:0042771", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042771", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB13", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB13" } ], "pmid": "" }, { "name": "double-strand break repair via nonhomologous end joining", "id": "GO:0006303", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006303", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB13", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB13" } ], "pmid": "" }, { "name": "response to ionizing radiation", "id": "GO:0010212", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010212", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB13", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB13" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB13", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB13" } ], "pmid": "" }, { "name": "Ku70:Ku80 complex", "id": "GO:0043564", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043564", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB13", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB13" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 119, "end_pos": 121, "annotation": "n_glycosylation_sequon" }, { "start_pos": 580, "end_pos": 582, "annotation": "n_glycosylation_sequon" }, { "start_pos": 621, "end_pos": 623, "annotation": "n_glycosylation_sequon" }, { "start_pos": 75, "end_pos": 77, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.agr", "label": "AGR Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 119, "end_pos": 121 }, { "start_pos": 580, "end_pos": 582 }, { "start_pos": 621, "end_pos": 623 }, { "start_pos": 75, "end_pos": 77 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 11 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }