{ "uniprot_canonical_ac": "A0A0R4IB08-1", "uniprot_ac": "A0A0R4IB08", "uniprot_id": "A0A0R4IB08_DANRE", "mass": { "chemical_mass": 85814.0, "monoisotopic_mass": 85814.0 }, "refseq": { "ac": "NP_001338595", "name": "C-Jun-amino-terminal kinase-interacting protein 1a", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001338595" }, "gene_names": [ { "name": "mapk8ip1a", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB08", "id": "A0A0R4IB08" }, { "name": "mapk8ip1a", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001338595", "id": "NP_001338595" }, { "name": "mapk8ip1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001338595", "id": "NP_001338595" }, { "name": "mapk8ip1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB08", "id": "A0A0R4IB08" } ], "protein_names": [ { "name": "C-Jun-amino-terminal kinase-interacting protein 1a", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001338595", "id": "NP_001338595" }, { "name": "C-Jun-amino-terminal kinase-interacting protein 1a", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB08/entry#names_and_taxonomy", "id": "A0A0R4IB08" }, { "name": "Mitogen-activated protein kinase 8-interacting protein 1a", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB08/entry#names_and_taxonomy", "id": "A0A0R4IB08" }, { "name": "mitogen-activated protein kinase 8 interacting protein 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001338595", "id": "NP_001338595" } ], "function": [ { "annotation": "##Evidence-Data-START## Transcript exon combination :: SRR32588727.861492.1, SRR32588717.20249067.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505371, SAMEA3505376 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000025.1. On Jun 25, 2025 this sequence version replaced NP_001338595.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.", "evidence": [ { "database": "RefSeq", "id": "NP_001338595", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001338595" } ] } ], "disease": [ { "disease_id": "DOID:9352", "recommended_name": { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "type 2 diabetes mellitus", "description": "A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin." }, "synonyms": [ { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "NIDDM", "description": "" }, { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "non-insulin-dependent diabetes mellitus", "description": "" }, { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "type 2 diabetes", "description": "" }, { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "type II diabetes mellitus", "description": "" }, { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "insulin resistance", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "diabetes mellitus, noninsulin-dependent, 4", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "diabetes mellitus, noninsulin-dependent, 4", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "diabetes mellitus, noninsulin-dependent, type 4", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "Niddm4", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "noninsulin-dependent diabetes mellitus 4", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes mellitus", "description": "A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity." }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "NIDDM", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "T2D", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "T2DM", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "T2DM - type 2 diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "adult onset diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "adult-onset diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitis type 2", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitis type II", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent, association with", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent, late onset", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type 2", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type II", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes, type 2", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "insulin resistance, severe, digenic", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "non-insulin dependent diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "non-insulin dependent diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "non-insulin-dependent diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "noninsulin dependent diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "noninsulin-dependent diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes mellitus non-insulin dependent", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type II diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type II diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent, 2", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, non-insulin-dependent, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type 2, protection against", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type 2, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type II, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "hypertension, insulin resistance-related, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "insulin resistance, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "maturity-onset diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes mellitus, susceptibility to", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "diabetes mellitus, noninsulin-dependent, 1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "diabetes mellitus, noninsulin-dependent 1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "diabetes mellitus, noninsulin-dependent, 1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "diabetes mellitus, noninsulin-dependent, type 1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "NIDDM1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "noninsulin-dependent diabetes mellitus 1", "description": "" }, { "id": "MONDO:0011072", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011072", "name": "diabetes mellitus, noninsulin-dependent, 2", "description": "" }, { "id": "MONDO:0011072", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011072", "name": "NIDDM2", "description": "" }, { "id": "MONDO:0011072", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011072", "name": "diabetes mellitus, noninsulin-dependent, 2", "description": "" }, { "id": "MONDO:0011072", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011072", "name": "noninsulin-dependent diabetes mellitus 2", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "diabetes mellitus, noninsulin-dependent, 3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "diabetes mellitus, noninsulin-dependent, 3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "diabetes mellitus, noninsulin-dependent, type 3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "type 2 diabetes mellitus 3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "NIDDM3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "noninsulin-dependent diabetes mellitus 3", "description": "" }, { "id": "MIM:125853", "resource": "MIM", "url": "https://www.omim.org/entry/125853", "name": "Type 2 diabetes mellitus", "description": "Type 2 diabetes mellitus" }, { "id": "MIM:601283", "resource": "MIM", "url": "https://www.omim.org/entry/601283", "name": "Type 2 diabetes mellitus 1", "description": "Type 2 diabetes mellitus 1" } ], "unlinked_id_list": [], "evidence": [ { "id": "9352", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:9352" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Danio rerio", "taxid": 7955, "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB08", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB08" } ], "common_name": "Zebrafish", "glygen_name": "Zebrafish", "reference_species": "Danio rerio [7955]" } ], "gene": [ { "name": "mapk8ip1a", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB08", "locus": {} } ], "crossref": [ { "id": "ZFIN:ZDB-GENE-101025-1", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-101025-1", "database": "AGR", "categories": [ "Protein Classification" ] }, { "id": "ENSDARG00000102229", "url": "https://bgee.org/?page=gene&gene_id=ENSDARG00000102229", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01212", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01212", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11943", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11943", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100537717", "url": "https://www.ncbi.nlm.nih.gov/gene/100537717", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006020", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006020", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035638", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035638", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047178", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047178", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dre:100537717", "url": "https://www.genome.jp/dbget-bin/www_bget?dre:100537717", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "MDSREDG", "url": "https://omabrowser.org/oma/group/MDSREDG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A0R4IB08", "url": "https://www.orthodb.org/?gene=A0A0R4IB08", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47437", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47437", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47437:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47437:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00640", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00640", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF14604", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14604", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "NP_001338595", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001338595", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A0R4IB08", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB08", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0R4IB08-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB08-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "ZDB-GENE-101025-1", "url": "https://zfin.org/ZDB-GENE-101025-1", "database": "ZFIN", "categories": [ "Protein", "Organism-specific" ] } ], "sequence": { "sequence": "MVLSLAMDSREEWDGWMEEQWEKWLTHDISLDEYEDDDLSEVTEITDENGITLVHLDLDTQDHMTRPTNGAARSGRRREAVELQAEMLHLDLIDAEGGIQEEERDDRRPFDAIDDNHKEERGAGPPVILPQLKTLTPANDMDTYRPKRPTTLNLFPQVPRTQDTINNNSFGEKERRKEKKTHSSSPHIKGDSAAKPEQGSLTDGDKVQARADTKPRGPASTKNKASAFQNKQQDKLSESLNNPTVVAPLTQTAMRDKSTEVPLIEGVLDISTICKEKARYHTVNGYREQVQYPAENEGMCDQLVDRNKDYHISEGNATEEIHLTPVNGEQERPFLSQSSDSNRMSISSDTELPPLHYYPSAGCPNPSISEEDEVYPPTPPCRTVSLSEQPGDSSQWAETRKPKMAKDETGNVKAVAVSTDASGLTYDSVKYTLVVDEHAKLELVSIKDCYKGYESDSDNTVYESAIDEDDEDQEADEEDEESGARSMRRDTSCLSADSTTDTTSDVPRSRKFMNIFGNGRSRFSGAEFGFFSCVINGEEREQSHRAVFRFVPRHDDELELEADDPLLVELQAEDLWCEAYNMRTGTRGIFPAFYAVKVAKDELVKEVKGDWMDKFWVKFLGSVQVPYHKGNDVLCAAMHKIASNRRTTMQFSPPSPCIVEINTRGLKIVVQDDCRTSGRGEKCFHFFQLKNISFCGCHPKNNKYFGLITKHPANQRFACHVFFSDDTTTKLAESVGKAFQQFYKEHMEYSCPTEDIFLE", "length": 759, "header": "tr|A0A0R4IB08-1|A0A0R4IB08_DANRE Isoform 1 of Mitogen-activated protein kinase 8-interacting protein 1a OS=Danio rerio OX=7955 GN=mapk8ip1a PE=3 SV=1 CANONICAL=A0A0R4IB08-1" }, "isoforms": [ { "isoform_ac": "A0A0R4IB08-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB08/entry#A0A0R4IB08-1", "sequence": { "sequence": "MVLSLAMDSREEWDGWMEEQWEKWLTHDISLDEYEDDDLSEVTEITDENGITLVHLDLDTQDHMTRPTNGAARSGRRREAVELQAEMLHLDLIDAEGGIQEEERDDRRPFDAIDDNHKEERGAGPPVILPQLKTLTPANDMDTYRPKRPTTLNLFPQVPRTQDTINNNSFGEKERRKEKKTHSSSPHIKGDSAAKPEQGSLTDGDKVQARADTKPRGPASTKNKASAFQNKQQDKLSESLNNPTVVAPLTQTAMRDKSTEVPLIEGVLDISTICKEKARYHTVNGYREQVQYPAENEGMCDQLVDRNKDYHISEGNATEEIHLTPVNGEQERPFLSQSSDSNRMSISSDTELPPLHYYPSAGCPNPSISEEDEVYPPTPPCRTVSLSEQPGDSSQWAETRKPKMAKDETGNVKAVAVSTDASGLTYDSVKYTLVVDEHAKLELVSIKDCYKGYESDSDNTVYESAIDEDDEDQEADEEDEESGARSMRRDTSCLSADSTTDTTSDVPRSRKFMNIFGNGRSRFSGAEFGFFSCVINGEEREQSHRAVFRFVPRHDDELELEADDPLLVELQAEDLWCEAYNMRTGTRGIFPAFYAVKVAKDELVKEVKGDWMDKFWVKFLGSVQVPYHKGNDVLCAAMHKIASNRRTTMQFSPPSPCIVEINTRGLKIVVQDDCRTSGRGEKCFHFFQLKNISFCGCHPKNNKYFGLITKHPANQRFACHVFFSDDTTTKLAESVGKAFQQFYKEHMEYSCPTEDIFLE", "length": 759, "header": "tr|A0A0R4IB08-1|A0A0R4IB08_DANRE Isoform 1 of Mitogen-activated protein kinase 8-interacting protein 1a OS=Danio rerio OX=7955 GN=mapk8ip1a PE=3 SV=1 CANONICAL=A0A0R4IB08-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "start_pos": 378, "start_aa": "Thr", "end_pos": 378, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr378", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "00000000000000001000.00000000001000.0.xxxxx" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "The zebrafish reference genome sequence and its relationship to the human genome.", "journal": "Nature", "date": "2013", "authors": "Howe Kerstin, Clark Matthew D, Torroja Carlos F, Torrance James, Berthelot Camille, Muffato Matthieu, Collins John E, Humphray Sean, McLaren Karen, Matthews Lucy, McLaren Stuart, Sealy Ian, Caccamo Mario, Churcher Carol, Scott Carol, Barrett Jeffrey C, Koch Romke, Rauch Gerd-J\u00f6rg, White Simon, Chow William, Kilian Britt, Quintais Leonor T, Guerra-Assun\u00e7\u00e3o Jos\u00e9 A, Zhou Yi, Gu Yong, Yen Jennifer, Vogel Jan-Hinnerk, Eyre Tina, Redmond Seth, Banerjee Ruby, Chi Jianxiang, Fu Beiyuan, Langley Elizabeth, Maguire Sean F, Laird Gavin K, Lloyd David, Kenyon Emma, Donaldson Sarah, Sehra Harminder, Almeida-King Jeff, Loveland Jane, Trevanion Stephen, Jones Matt, Quail Mike, Willey Dave, Hunt Adrienne, Burton John, Sims Sarah, McLay Kirsten, Plumb Bob, Davis Joy, Clee Chris, Oliver Karen, Clark Richard, Riddle Clare, Elliot David, Eliott David, Threadgold Glen, Harden Glenn, Ware Darren, Begum Sharmin, Mortimore Beverley, Mortimer Beverly, Kerry Giselle, Heath Paul, Phillimore Benjamin, Tracey Alan, Corby Nicole, Dunn Matthew, Johnson Christopher, Wood Jonathan, Clark Susan, Pelan Sarah, Griffiths Guy, Smith Michelle, Glithero Rebecca, Howden Philip, Barker Nicholas, Lloyd Christine, Stevens Christopher, Harley Joanna, Holt Karen, Panagiotidis Georgios, Lovell Jamieson, Beasley Helen, Henderson Carl, Gordon Daria, Auger Katherine, Wright Deborah, Collins Joanna, Raisen Claire, Dyer Lauren, Leung Kenric, Robertson Lauren, Ambridge Kirsty, Leongamornlert Daniel, McGuire Sarah, Gilderthorp Ruth, Griffiths Coline, Manthravadi Deepa, Nichol Sarah, Barker Gary, Whitehead Siobhan, Kay Michael, Brown Jacqueline, Murnane Clare, Gray Emma, Humphries Matthew, Sycamore Neil, Barker Darren, Saunders David, Wallis Justene, Babbage Anne, Hammond Sian, Mashreghi-Mohammadi Maryam, Barr Lucy, Martin Sancha, Wray Paul, Ellington Andrew, Matthews Nicholas, Ellwood Matthew, Woodmansey Rebecca, Clark Graham, Cooper James D, Cooper James, Tromans Anthony, Grafham Darren, Skuce Carl, Pandian Richard, Andrews Robert, Harrison Elliot, Kimberley Andrew, Garnett Jane, Fosker Nigel, Hall Rebekah, Garner Patrick, Kelly Daniel, Bird Christine, Palmer Sophie, Gehring Ines, Berger Andrea, Dooley Christopher M, Ersan-\u00dcr\u00fcn Z\u00fcbeyde, Eser Cigdem, Geiger Horst, Geisler Maria, Karotki Lena, Kirn Anette, Konantz Judith, Konantz Martina, Oberl\u00e4nder Martina, Rudolph-Geiger Silke, Teucke Mathias, Lanz Christa, Raddatz G\u00fcnter, Osoegawa Kazutoyo, Zhu Baoli, Rapp Amanda, Widaa Sara, Langford Cordelia, Yang Fengtang, Schuster Stephan C, Carter Nigel P, Harrow Jennifer, Ning Zemin, Herrero Javier, Searle Steve M J, Enright Anton, Geisler Robert, Plasterk Ronald H A, Lee Charles, Westerfield Monte, de Jong Pieter J, Zon Leonard I, Postlethwait John H, N\u00fcsslein-Volhard Christiane, Hubbard Tim J P, Roest Crollius Hugues, Rogers Jane, Stemple Derek L", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB08", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB08" } ], "reference": [ { "type": "PubMed", "id": "23594743", "url": "https://glygen.org/publication/PubMed/23594743" } ] }, { "title": "Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.", "journal": "BMC Genomics", "date": "2016", "authors": "Pasquier Jeremy, Cabau C\u00e9dric, Nguyen Thaovi, Jouanno Elodie, Severac Dany, Braasch Ingo, Journot Laurent, Pontarotti Pierre, Klopp Christophe, Postlethwait John H, Guiguen Yann, Bobe Julien", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB08", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB08" } ], "reference": [ { "type": "PubMed", "id": "27189481", "url": "https://glygen.org/publication/PubMed/27189481" } ] }, { "title": "Identification of zebrafish magnetoreceptor and cryptochrome homologs.", "journal": "Sci. China Life Sci.", "date": "2016", "authors": "Zhou Zuoqiong, Peng Xiyang, Chen Jianbin, Wu Xiushan, Wang Yuequn, Hong Yunhan", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB08", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB08" } ], "reference": [ { "type": "PubMed", "id": "27614751", "url": "https://glygen.org/publication/PubMed/27614751" } ] } ], "pathway": [ { "id": "dre:100537717", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?dre:100537717", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8M3AUR2-1", "protein_name": "C-Jun-amino-terminal kinase-interacting protein 1", "gene_name": "mapk8ip1b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDSNGDGNDEWTEEQWEKWLTHDIGLDEFEDEDLSEITEITDEYAFKARRNDSDIKDHVRQAPSAALGRIEAGAEGQIQPETQPLHLTDAADRSQTLACRHDSKASMDSAVPVSMEAYRPKRPTTLNLFPQVPRTQDTLNNNSFSKKFSWQQKISQTLPPRKGADLTPPCEHTCLSDEEKHQPSRAQMKDCGTSTTDKPNICPSKHTPAPAAAVYKPREAAHCERIRYHTDVRLEPTEEIYLTPIQRCTEPPETQKTKVMVSSDSEAPPPYSEQDLQPPSYFSCVEALAVDSSGDEEPTVDDLCYRDCGAGEAHAHHENLPKIIHTSMSNSDASGLSYDSVKYTLVVDEHDQLELVSLKECYRGYSDDSESPTVYDNCVSSPYESGLDKEYEEENDGEKLSRIKASFEDSTPEADIPFSRKFVNVFMNGCSRSSSTESFGLFSCLINGEEREQTHRAVYRFIPRHDDELELELNDPLLVELQDEDYWYEGYNMRTGARGIFPAYYATEVFREQELASDEVKSSEWVEKYTMKFLGSVQVMNHKGNDVLCAAMQKIAMNRRLTVHYNPPSSCILEITVKGLKLTVQDDFDMSSQYSHFFHLKNVSFCGYHPRNKKYFGFITKHPADERFACHVFVSENSTKPLAESVRKAFHLYYKEFVEVSCPTEDIYLE", "length": 670 }, "evidence": [ { "id": "HGNC:6882", "url": "https://alliancegenome.org/gene/HGNC:6882#orthology", "database": "AGR" }, { "id": "MGI:1309464", "url": "https://alliancegenome.org/gene/MGI:1309464#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q9R237-1", "protein_name": "C-Jun-amino-terminal kinase-interacting protein 1", "gene_name": "Mapk8ip1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAERESGLSGGAASPPAASPFLGLHIASPPNFRLTHDISLEEFEDEDLSEITDECGISLQCKDTLSLRPPRAGLLSAGSSGSAGSRLQAEMLQMDLIDAASDTPGAEDDEEDDDELAAQRPGVGPSKAESGQEPASRSQGQGQGPGTGSGDTYRPKRPTTLNLFPQVPRSQDTLNNNSLGKKHSWQDRVSRSSSPLKTGEQTPPHEHICLSDELPPQGSPVPTQDRGTSTDSPCRRTAATQMAPPSGPPATAPGGRGHSHRDRIHYQADVRLEATEEIYLTPVQRPPDPAEPTSTFLPPTESRMSVSSDPDPAAYSVTAGRPHPSISEEDEGFDCLSSPEQAEPPGGGWRGSLGEPPPPPRASLSSDTSALSYDSVKYTLVVDEHAQLELVSLRPCFGDYSDESDSATVYDNCASASSPYESAIGEEYEEAPQPRPPTCLSEDSTPDEPDVHFSKKFLNVFMSGRSRSSSAESFGLFSCVINGEEHEQTHRAIFRFVPRHEDELELEVDDPLLVELQAEDYWYEAYNMRTGARGVFPAYYAIEVTKEPEHMAALAKNSDWIDQFRVKFLGSVQVPYHKGNDVLCAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKIGVKADEAQEAKGNKCSHFFQLKNISFCGYHPKNNKYFGFITKHPADHRFACHVFVSEDSTKALAESVGRAFQQFYKQFVEYTCPTEDIYLE", "length": 708 }, "evidence": [ { "id": "HGNC:6882", "url": "https://alliancegenome.org/gene/HGNC:6882#orthology", "database": "AGR" }, { "id": "MGI:1309464", "url": "https://alliancegenome.org/gene/MGI:1309464#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9UQF2-1", "protein_name": "C-Jun-amino-terminal kinase-interacting protein 1", "gene_name": "MAPK8IP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAERESGGLGGGAASPPAASPFLGLHIASPPNFRLTHDISLEEFEDEDLSEITDECGISLQCKDTLSLRPPRAGLLSAGGGGAGSRLQAEMLQMDLIDATGDTPGAEDDEEDDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGPGSGDTYRPKRPTTLNLFPQVPRSQDTLNNNSLGKKHSWQDRVSRSSSPLKTGEQTPPHEHICLSDELPPQSGPAPTTDRGTSTDSPCRRSTATQMAPPGGPPAAPPGGRGHSHRDRIHYQADVRLEATEEIYLTPVQRPPDAAEPTSAFLPPTESRMSVSSDPDPAAYPSTAGRPHPSISEEEEGFDCLSSPERAEPPGGGWRGSLGEPPPPPRASLSSDTSALSYDSVKYTLVVDEHAQLELVSLRPCFGDYSDESDSATVYDNCASVSSPYESAIGEEYEEAPRPQPPACLSEDSTPDEPDVHFSKKFLNVFMSGRSRSSSAESFGLFSCIINGEEQEQTHRAIFRFVPRHEDELELEVDDPLLVELQAEDYWYEAYNMRTGARGVFPAYYAIEVTKEPEHMAALAKNSDWVDQFRVKFLGSVQVPYHKGNDVLCAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKIGVKADDSQEAKGNKCSHFFQLKNISFCGYHPKNNKYFGFITKHPADHRFACHVFVSEDSTKALAESVGRAFQQFYKQFVEYTCPTEDIYLE", "length": 711 }, "evidence": [ { "id": "HGNC:6882", "url": "https://alliancegenome.org/gene/HGNC:6882#orthology", "database": "AGR" }, { "id": "MGI:1309464", "url": "https://alliancegenome.org/gene/MGI:1309464#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-101025-1", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-101025-1#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9W0K0-1", "protein_name": "JNK-interacting protein 1", "gene_name": "Aplip1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MADSEFEEFHRPIFEPHTIAGFGSGAGSKKNNPHAFYSLIPNDDLEDSHSSKSDGDGSDQEDGIGLVDHEPKMRQVEDDELGDGLKVTLSSDGSLDTNDSFNSHRHHPLNHQDAIGGFLGMDTSGLGGNSAPVTIGASTDLLAPNTAATRRRRKLPEIPKNKKSSILHLLGGSNFGSLADEFRNGGGGGIPPAVRSGQQRSFLSLKCGYLMDEDSSPDSERMQSLGDVDSGHSTAHSPNDFKSMSPQITSPVSQSPFPPPFGGVPFGQLEMLEATHRGLHKFVPRHHDEIELEIGDAIYVQKEAEDLWCEGVNLRTGRQGIFPSAYAVDLDYNEFDPTVQLVKKERYLLGYLGSVETLAHKGTGVVCQAVRKIVGEYGNSPTGQTCILEVSDQGLRMVDRSGPNQNKKDKKPCIDYFYSLKNVSFCAFHPRDHRFIGFITKHPTVQRFACHVFKGSESTRPVAEAVGRAFQRFYQKFIETAYPIEDIYIE", "length": 490 }, "evidence": [ { "id": "HGNC:6882", "url": "https://alliancegenome.org/gene/HGNC:6882#orthology", "database": "AGR" }, { "id": "MGI:1309464", "url": "https://alliancegenome.org/gene/MGI:1309464#orthology", "database": "AGR" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9WVI9-1", "protein_name": "C-Jun-amino-terminal kinase-interacting protein 1", "gene_name": "Mapk8ip1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAERESGLGGGAASPPAASPFLGLHIASPPNFRLTHDISLEEFEDEDLSEITDECGISLQCKDTLSLRPPRAGLLSAGSSGSAGSRLQAEMLQMDLIDAAGDTPGAEDDEEEEDDELAAQRPGVGPPKAESNQDPAPRSQGQGPGTGSGDTYRPKRPTTLNLFPQVPRSQDTLNNNSLGKKHSWQDRVSRSSSPLKTGEQTPPHEHICLSDELPPQGSPVPTQDRGTSTDSPCRRSAATQMAPPSGPPATAPGGRGHSHRDRIHYQADVRLEATEEIYLTPVQRPPDPAEPTSTFMPPTESRMSVSSDPDPAAYSVTAGRPHPSISEEDEGFDCLSSPERAEPPGGGWRGSLGEPPPPPRASLSSDTSALSYDSVKYTLVVDEHAQLELVSLRPCFGDYSDESDSATVYDNCASASSPYESAIGEEYEEAPQPRPPTCLSEDSTPDEPDVHFSKKFLNVFMSGRSRSSSAESFGLFSCVINGEEHEQTHRAIFRFVPRHEDELELEVDDPLLVELQAEDYWYEAYNMRTGARGVFPAYYAIEVTKEPEHMAALAKNSDWIDQFRVKFLGSVQVPYHKGNDVLCAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKIGVKADDALEAKGNKCSHFFQLKNISFCGYHPKNNKYFGFITKHPADHRFACHVFVSEDSTKALAESVGRAFQQFYKQFVEYTCPTEDIYLE", "length": 707 }, "evidence": [ { "id": "HGNC:6882", "url": "https://alliancegenome.org/gene/HGNC:6882#orthology", "database": "AGR" }, { "id": "MGI:1309464", "url": "https://alliancegenome.org/gene/MGI:1309464#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-101025-1", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-101025-1#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB08", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB08" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "JNK cascade", "id": "GO:0007254", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007254", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB08", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB08" } ], "pmid": "" }, { "name": "regulation of JNK cascade", "id": "GO:0046328", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046328", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB08", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB08" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "MAP-kinase scaffold activity", "id": "GO:0005078", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005078", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB08", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB08" } ], "pmid": "" }, { "name": "kinase activity", "id": "GO:0016301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016301", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB08", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB08" } ], "pmid": "" }, { "name": "JUN kinase binding", "id": "GO:0008432", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008432", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB08", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB08" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 167, "end_pos": 169, "annotation": "n_glycosylation_sequon" }, { "start_pos": 316, "end_pos": 318, "annotation": "n_glycosylation_sequon" }, { "start_pos": 691, "end_pos": 693, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.agr", "label": "AGR Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 378 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 167, "end_pos": 169 }, { "start_pos": 316, "end_pos": 318 }, { "start_pos": 691, "end_pos": 693 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { 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