{ "uniprot_canonical_ac": "A0A0R4IB00-1", "uniprot_ac": "A0A0R4IB00", "uniprot_id": "A0A0R4IB00_DANRE", "mass": { "chemical_mass": 68960.0, "monoisotopic_mass": 68960.0 }, "refseq": { "ac": "NP_001352431", "name": "matrix metalloproteinase-17b isoform 1 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001352431" }, "gene_names": [ { "name": "mmp17b", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB00", "id": "A0A0R4IB00" }, { "name": "mmp17b", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001352431", "id": "NP_001352431" }, { "name": "mmpl2; sb:eu434; si:ch211-199b20.1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001352431", "id": "NP_001352431" }, { "name": "mmpl2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB00", "id": "A0A0R4IB00" }, { "name": "sb:eu434", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB00", "id": "A0A0R4IB00" }, { "name": "si:ch211-199b20.1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB00", "id": "A0A0R4IB00" } ], "protein_names": [ { "name": "MMPLd; matrix metallopeptidase like 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001352431", "id": "NP_001352431" }, { "name": "Matrix metallopeptidase 17b", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB00/entry#names_and_taxonomy", "id": "A0A0R4IB00" }, { "name": "Matrix metalloproteinase-17b isoform 1 precursor", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB00/entry#names_and_taxonomy", "id": "A0A0R4IB00" }, { "name": "matrix metalloproteinase-17b isoform 1 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001352431", "id": "NP_001352431" } ], "function": [ { "annotation": "##Evidence-Data-START## Transcript exon combination :: SRR32588714.37648867.1, SRR32588733.1469454.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505390, SAMEA4476731 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000014.1. On Aug 30, 2018 this sequence version replaced XP_002664536.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.", "evidence": [ { "database": "RefSeq", "id": "NP_001352431", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001352431" } ] }, { "annotation": "Mmp17b is essential for proper neural crest cell migration in vivo. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001352431", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001352431" }, { "database": "PubMed", "id": "24098510", "url": "https://glygen.org/publication/PubMed/24098510" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Danio rerio", "taxid": 7955, "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB00", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB00" } ], "common_name": "Zebrafish", "glygen_name": "Zebrafish", "reference_species": "Danio rerio [7955]" } ], "gene": [ { "name": "mmp17b", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB00", "locus": {} } ], "crossref": [ { "id": "ZFIN:ZDB-GENE-081107-17", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-081107-17", "database": "AGR", "categories": [ "Protein Classification" ] }, { "id": "ENSDARG00000102956", "url": "https://bgee.org/?page=gene&gene_id=ENSDARG00000102956", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00094", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00094", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd04278", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04278", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100322027", "url": "https://www.ncbi.nlm.nih.gov/gene/100322027", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000585", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000585", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001818", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001818", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002477", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002477", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006026", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006026", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018487", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018487", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021190", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021190", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024079", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024079", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR033739", "url": "https://www.ebi.ac.uk/interpro/entry/IPR033739", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036365", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036365", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036375", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036375", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dre:100322027", "url": "https://www.genome.jp/dbget-bin/www_bget?dre:100322027", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "LQDGYPQ", "url": "https://omabrowser.org/oma/group/LQDGYPQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A0R4IB00", "url": "https://www.orthodb.org/?gene=A0A0R4IB00", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10201", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10201", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10201:SF224", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10201:SF224", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00045", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00045", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00413", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00413", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF01471", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01471", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "NP_001352431", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001352431", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A0R4IB00", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB00", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0R4IB00-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB00-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AB13A3M6", "url": "https://www.uniprot.org/uniprotkb/A0AB13A3M6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AB13A3M6-1", "url": "https://www.uniprot.org/uniprotkb/A0AB13A3M6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "ZDB-GENE-081107-17", "url": "https://zfin.org/ZDB-GENE-081107-17", "database": "ZFIN", "categories": [ "Protein", "Organism-specific" ] } ], "sequence": { "sequence": "MMLMFWTAVVFCLWGSAVDVFGEANEDALPTSLMNMVTSTILPTAIPTEDESGKLVDWLTKYGYLPPPDPSTGQLQAWTAVTQAVKKMQSFAGLDETGILDEETLQLMQTPRCSLPDDDDDDQTIHSAQHADPQNQRMKRAVSTWTRRNINWRLRSYPVSSKLSRETIRSLVFYALRVWADPTLLEFHEVRGPEGADLQIDFLHGPHGDGYPFDGAGGSVGHAFFPSDPNRAGGVHLDAEEDWAFRQPATEGTDLFTVLVHELGHALGLTHSSARRSVMRPYYQGPLGDPLHFSLGYQDLQHITALYGQRGNDIPTETPLPVTETQLRHRHHRLTHMYRHAHSHPDSSVDRCNTSFDAVAKIRGEIFFFKGQSMWRISRGGLVSVRVVPIQRLWSALPPSLPPLRAVLERHTDHAIIFISGSQVWLFKDLSLQDGFPQPLPTLADSDGGFEGLRWDPTQGVVWGSIREEEQNEDNKVWRELIEGGVNGIIMENDHQRETNRGFKGSTYIFKGNSYWKFTHPGSAPVEGYPRLSASDWLDCPQDSSYSSADISLISQFGQQELHEQKKQTIINQIRHSEINKPQHWDCPCQNTAGTQRGHVLLLAFLLLLTVTC", "length": 613, "header": "tr|A0A0R4IB00-1|A0A0R4IB00_DANRE Isoform 1 of Matrix metallopeptidase 17b OS=Danio rerio OX=7955 GN=mmp17b PE=3 SV=1 CANONICAL=A0A0R4IB00-1" }, "isoforms": [ { "isoform_ac": "A0A0R4IB00-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB00/entry#A0A0R4IB00-1", "sequence": { "sequence": "MMLMFWTAVVFCLWGSAVDVFGEANEDALPTSLMNMVTSTILPTAIPTEDESGKLVDWLTKYGYLPPPDPSTGQLQAWTAVTQAVKKMQSFAGLDETGILDEETLQLMQTPRCSLPDDDDDDQTIHSAQHADPQNQRMKRAVSTWTRRNINWRLRSYPVSSKLSRETIRSLVFYALRVWADPTLLEFHEVRGPEGADLQIDFLHGPHGDGYPFDGAGGSVGHAFFPSDPNRAGGVHLDAEEDWAFRQPATEGTDLFTVLVHELGHALGLTHSSARRSVMRPYYQGPLGDPLHFSLGYQDLQHITALYGQRGNDIPTETPLPVTETQLRHRHHRLTHMYRHAHSHPDSSVDRCNTSFDAVAKIRGEIFFFKGQSMWRISRGGLVSVRVVPIQRLWSALPPSLPPLRAVLERHTDHAIIFISGSQVWLFKDLSLQDGFPQPLPTLADSDGGFEGLRWDPTQGVVWGSIREEEQNEDNKVWRELIEGGVNGIIMENDHQRETNRGFKGSTYIFKGNSYWKFTHPGSAPVEGYPRLSASDWLDCPQDSSYSSADISLISQFGQQELHEQKKQTIINQIRHSEINKPQHWDCPCQNTAGTQRGHVLLLAFLLLLTVTC", "length": 613, "header": "tr|A0A0R4IB00-1|A0A0R4IB00_DANRE Isoform 1 of Matrix metallopeptidase 17b OS=Danio rerio OX=7955 GN=mmp17b PE=3 SV=1 CANONICAL=A0A0R4IB00-1" }, "locus": {} }, { "isoform_ac": "A0AB13A3M6-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB00/entry#A0AB13A3M6-1", "sequence": { "sequence": "MMLMFWTAVVFCLWGSAVDVFGEANEDALPTSLMNMVTSTILPTAIPTEDESGKLVDWLTKYGYLPPPDPSTGQLQAWTAVTQAVKKMQSFAGLDETGILDEETLQLMQTPRCSLPDDDDDDQTIHSAQHADPQNQRMKRAVSTWTRRNINWRLRSYPVSSKLSRETIRSLVFYALRVWADPTLLEFHEVRGPEGADLQIDFLHGPHGDGYPFDGAGGSVGHAFFPSDPNRAGGVHLDAEEDWAFRQPATEGTDLFTVLVHELGHALGLTHSSARRSVMRPYYQGPLGDPLHFSLGYQDLQHITALYGQRGNDIPTETPLPVTETQLRHRHHRLTHMYRHAHSHPDSSVDRCNTSFDAVAKIRGEIFFFKGQSMWRISRGGLVSVRVVPIQRLWSALPPSLPPLRAVLERHTDHAIIFISGSTYIFKGNSYWKFTHPGSAPVEGYPRLSASDWLDCPQDSSYSSADISLISQFGQQELHEQKKQTIINQIRHSEINKPQHWDCPCQNTAGTQRGHVLLLAFLLLLTVTC", "length": 529, "header": "tr|A0AB13A3M6-1|A0AB13A3M6_DANRE Computationally mapped isoform of Matrix metalloproteinase-17b isoform 2 precursor OS=Danio rerio OX=7955 GN=mmp17b PE=3 SV=1 CANONICAL=A0A0R4IB00-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "The evolution of the vertebrate metzincins; insights from Ciona intestinalis and Danio rerio.", "journal": "BMC Evol. Biol.", "date": "2007", "authors": "Huxley-Jones Julie, Clarke Toni-Kim, Beck Christine, Toubaris George, Robertson David L, Boot-Handford Raymond P", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB00", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB00" } ], "reference": [ { "type": "PubMed", "id": "17439641", "url": "https://glygen.org/publication/PubMed/17439641" } ] }, { "title": "The zebrafish embryo: a powerful model system for investigating matrix remodeling.", "journal": "Zebrafish", "date": "2009", "authors": "Wyatt Rachael A, Keow Jonathan Y, Harris Natalie D, Hach\u00e9 Charles A, Li Daniel H, Crawford Bryan D", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB00", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB00" } ], "reference": [ { "type": "PubMed", "id": "19929220", "url": "https://glygen.org/publication/PubMed/19929220" } ] }, { "title": "The zebrafish reference genome sequence and its relationship to the human genome.", "journal": "Nature", "date": "2013", "authors": "Howe Kerstin, Clark Matthew D, Torroja Carlos F, Torrance James, Berthelot Camille, Muffato Matthieu, Collins John E, Humphray Sean, McLaren Karen, Matthews Lucy, McLaren Stuart, Sealy Ian, Caccamo Mario, Churcher Carol, Scott Carol, Barrett Jeffrey C, Koch Romke, Rauch Gerd-J\u00f6rg, White Simon, Chow William, Kilian Britt, Quintais Leonor T, Guerra-Assun\u00e7\u00e3o Jos\u00e9 A, Zhou Yi, Gu Yong, Yen Jennifer, Vogel Jan-Hinnerk, Eyre Tina, Redmond Seth, Banerjee Ruby, Chi Jianxiang, Fu Beiyuan, Langley Elizabeth, Maguire Sean F, Laird Gavin K, Lloyd David, Kenyon Emma, Donaldson Sarah, Sehra Harminder, Almeida-King Jeff, Loveland Jane, Trevanion Stephen, Jones Matt, Quail Mike, Willey Dave, Hunt Adrienne, Burton John, Sims Sarah, McLay Kirsten, Plumb Bob, Davis Joy, Clee Chris, Oliver Karen, Clark Richard, Riddle Clare, Elliot David, Eliott David, Threadgold Glen, Harden Glenn, Ware Darren, Begum Sharmin, Mortimore Beverley, Mortimer Beverly, Kerry Giselle, Heath Paul, Phillimore Benjamin, Tracey Alan, Corby Nicole, Dunn Matthew, Johnson Christopher, Wood Jonathan, Clark Susan, Pelan Sarah, Griffiths Guy, Smith Michelle, Glithero Rebecca, Howden Philip, Barker Nicholas, Lloyd Christine, Stevens Christopher, Harley Joanna, Holt Karen, Panagiotidis Georgios, Lovell Jamieson, Beasley Helen, Henderson Carl, Gordon Daria, Auger Katherine, Wright Deborah, Collins Joanna, Raisen Claire, Dyer Lauren, Leung Kenric, Robertson Lauren, Ambridge Kirsty, Leongamornlert Daniel, McGuire Sarah, Gilderthorp Ruth, Griffiths Coline, Manthravadi Deepa, Nichol Sarah, Barker Gary, Whitehead Siobhan, Kay Michael, Brown Jacqueline, Murnane Clare, Gray Emma, Humphries Matthew, Sycamore Neil, Barker Darren, Saunders David, Wallis Justene, Babbage Anne, Hammond Sian, Mashreghi-Mohammadi Maryam, Barr Lucy, Martin Sancha, Wray Paul, Ellington Andrew, Matthews Nicholas, Ellwood Matthew, Woodmansey Rebecca, Clark Graham, Cooper James D, Cooper James, Tromans Anthony, Grafham Darren, Skuce Carl, Pandian Richard, Andrews Robert, Harrison Elliot, Kimberley Andrew, Garnett Jane, Fosker Nigel, Hall Rebekah, Garner Patrick, Kelly Daniel, Bird Christine, Palmer Sophie, Gehring Ines, Berger Andrea, Dooley Christopher M, Ersan-\u00dcr\u00fcn Z\u00fcbeyde, Eser Cigdem, Geiger Horst, Geisler Maria, Karotki Lena, Kirn Anette, Konantz Judith, Konantz Martina, Oberl\u00e4nder Martina, Rudolph-Geiger Silke, Teucke Mathias, Lanz Christa, Raddatz G\u00fcnter, Osoegawa Kazutoyo, Zhu Baoli, Rapp Amanda, Widaa Sara, Langford Cordelia, Yang Fengtang, Schuster Stephan C, Carter Nigel P, Harrow Jennifer, Ning Zemin, Herrero Javier, Searle Steve M J, Enright Anton, Geisler Robert, Plasterk Ronald H A, Lee Charles, Westerfield Monte, de Jong Pieter J, Zon Leonard I, Postlethwait John H, N\u00fcsslein-Volhard Christiane, Hubbard Tim J P, Roest Crollius Hugues, Rogers Jane, Stemple Derek L", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB00", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB00" } ], "reference": [ { "type": "PubMed", "id": "23594743", "url": "https://glygen.org/publication/PubMed/23594743" } ] }, { "title": "Mmp17b is essential for proper neural crest cell migration in vivo.", "journal": "PLoS ONE", "date": "2013", "authors": "Leigh Noah R, Schupp Marcus-Oliver, Li Keguo, Padmanabhan Vakeel, Gastonguay Adam, Wang Ling, Chun Chang Z, Wilkinson George A, Ramchandran Ramani", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB00", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB00" }, { "database": "RefSeq", "id": "NP_001352431", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001352431" } ], "reference": [ { "type": "PubMed", "id": "24098510", "url": "https://glygen.org/publication/PubMed/24098510" } ] }, { "title": "Phenotype anchoring in zebrafish reveals a potential role for matrix metalloproteinases (MMPs) in tamoxifen's effects on skin epithelium.", "journal": "Toxicol. Appl. Pharmacol.", "date": "2016", "authors": "Bugel Sean M, Wehmas Leah C, La Du Jane K, Tanguay Robert L", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB00", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB00" } ], "reference": [ { "type": "PubMed", "id": "26908177", "url": "https://glygen.org/publication/PubMed/26908177" } ] }, { "title": "Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.", "journal": "BMC Genomics", "date": "2016", "authors": "Pasquier Jeremy, Cabau C\u00e9dric, Nguyen Thaovi, Jouanno Elodie, Severac Dany, Braasch Ingo, Journot Laurent, Pontarotti Pierre, Klopp Christophe, Postlethwait John H, Guiguen Yann, Bobe Julien", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB00", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB00" } ], "reference": [ { "type": "PubMed", "id": "27189481", "url": "https://glygen.org/publication/PubMed/27189481" } ] }, { "title": "Lef1-dependent hypothalamic neurogenesis inhibits anxiety.", "journal": "PLoS Biol.", "date": "2017", "authors": "Xie Yuanyuan, Kaufmann Dan, Moulton Matthew J, Panahi Samin, Gaynes John A, Watters Harrison N, Zhou Dingxi, Xue Hai-Hui, Fung Camille M, Levine Edward M, Letsou Anthea, Brennan K C, Dorsky Richard I", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB00", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB00" } ], "reference": [ { "type": "PubMed", "id": "28837622", "url": "https://glygen.org/publication/PubMed/28837622" } ] }, { "title": "Dynamic control of proinflammatory cytokines Il-1beta and Tnf-alpha by macrophages in zebrafish spinal cord regeneration.", "journal": "Nat. Commun.", "date": "2018", "authors": "Tsarouchas Themistoklis M, Wehner Daniel, Cavone Leonardo, Munir Tahimina, Keatinge Marcus, Lambertus Marvin, Underhill Anna, Barrett Thomas, Kassapis Elias, Ogryzko Nikolay, Feng Yi, van Ham Tjakko J, Becker Thomas, Becker Catherina G", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB00", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB00" } ], "reference": [ { "type": "PubMed", "id": "30405119", "url": "https://glygen.org/publication/PubMed/30405119" } ] }, { "title": "Spinal cord precursors utilize neural crest cell mechanisms to generate hybrid peripheral myelinating glia.", "journal": "Elife", "date": "2021", "authors": "Fontenas Laura, Kucenas Sarah", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB00", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB00" } ], "reference": [ { "type": "PubMed", "id": "33554855", "url": "https://glygen.org/publication/PubMed/33554855" } ] }, { "title": "CFTR regulates embryonic T lymphopoiesis via Wnt signaling in zebrafish.", "journal": "Immunol. Lett.", "date": "2021", "authors": "Lin Ziyuan, Luo Min, Zhou Bin, Liu Yanyan, Sun Huaqin", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB00", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB00" } ], "reference": [ { "type": "PubMed", "id": "33951474", "url": "https://glygen.org/publication/PubMed/33951474" } ] }, { "title": "Unbiased characterization of the larval zebrafish enteric nervous system at a single cell transcriptomic level.", "journal": "IScience", "date": "2023", "authors": "Kuil Laura E, Kakiailatu Naomi J M, Windster Jonathan D, Bindels Eric, Zink Joke T M, van der Zee Gaby, Hofstra Robert M W, Shepherd Iain T, Melotte Veerle, Alves Maria M", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB00", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB00" } ], "reference": [ { "type": "PubMed", "id": "37426341", "url": "https://glygen.org/publication/PubMed/37426341" } ] } ], "pathway": [ { "id": "dre:100322027", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?dre:100322027", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8N7UVC2-1", "protein_name": "Matrix metalloproteinase-17", "gene_name": "mmp17a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MKSLRKWNSARTIWIIYPEMILFPVLWFLSQTRAAPSITAEQMDMGVDWLSKFGYLPPSDPVNGQLQTKEALTKAIKAMQRFGGLEETGVLDQATLGLMKTPRCSLPDMSEPDLSAGRRKRALAPQNKWNKRHLSWRVRTFPKESTSLGRDTVRALMYYALKVWSDIAPLNFHEVAGNEADIQIDFTKADHNDGYPFDGPGGTVAHAFFPGERFTAGDTHFDDDEAWTFRAPDSHGMDLFAVAVHEFGHAIGLAHTSAIESIMRPYYQGPVGDPLKYNLAYEDKVRVWQLYGVRDSVSHTLKPDDPSQTAEPPVLLDLPENRSTIPPARDAPDRCTSHFDAVAQIRGEAFFFKGKYFWRLTREKHLVSLRPAQIHRFWRGLPANLDSVDAVYERPGDHKIVFFKGGKYWVFKDNNVEEGYPRSVSDFGLPVEGVDAVFVWQHNEKTYFFKDNRYWRYDDHLRRMDLGYPKDMALWKGIPAQLDDAMRWSDSASYFFKGKEYWRVAGSDMEVEVGYPRPIGKDWLVCTEMQSDSPEMQNNSNTRLHGQHHADHAENGYEVCSCTSDSASPLGTRLTLSPAWVFAPLLTLALALSSAPL", "length": 597 }, "evidence": [ { "id": "MGI:1346076", "url": "https://alliancegenome.org/gene/MGI:1346076#orthology", "database": "AGR" }, { "id": "HGNC:7163", "url": "https://alliancegenome.org/gene/HGNC:7163#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "D3ZXJ0-1", "protein_name": "Matrix metalloproteinase-17", "gene_name": "Mmp17", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGRRPRGPGSPRGPGPPRPGPGLPPLLLMLALAAHGGCAAPAPRAEDLSLGVEWLSKFGYLPPADPATGQLQTQEELSKAITAMQQFGGLETTGILDEATLALMKTPRCSLPDLPLGAQSRRRRQTPLPTKWSKRNLSWRVRTFPRDSPLGRDTVRALMYYALKVWSDITPLNFHEVAGNMADIQIDFSKADHNDGYPFDGPGGTVAHAFFPGDHHTAGDTHFDDDEAWTFRSSDAHGMDLFAVAVHEFGHAIGLSHVAAPSSIMQPYYQGPVGDPLRYGLPYEDRVRVWQLYGVRESVSPTAQLDTPEPEEPPLLPEPPNNRSSTPPQKDVPHRCTAHFDAVAQIRGEAFFFKGKYFWRLTRDRHLVSLQPAQMHRFWRGLPLHLDSVDAVYERTSDHKIVFFKGDRYWVFKDNNVEEGYPRPVSDFSLPPGGIDAVFSWAHNDRTYFFKDQLYWRYDDHTRRMDPGYPAQGPLWRGVPSVLDDAMRWSDGASYFFRGQEYWKVLDGELEAAPGYPQSTARDWLVCGEQLADAEDVGPGPQGRSGAQDGLAVCSCTSDAHRSALPPLLLLPPLLWGLWTSVSSTAS", "length": 587 }, "evidence": [ { "id": "MGI:1346076", "url": "https://alliancegenome.org/gene/MGI:1346076#orthology", "database": "AGR" }, { "id": "HGNC:7163", "url": "https://alliancegenome.org/gene/HGNC:7163#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8MPP3-1", "protein_name": "Matrix metalloproteinase-2", "gene_name": "Mmp2", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MFSKYVLATLLALFAQSMCIQELSLPPEGSHSTAATRSKKAKTAISEDIMYNYLMQFDYLPKSDLETGALRTEDQLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCGVGDRRSADSFSPDNLYHEIGSNVRVRRFALQGPKWSRTDLTWSMVNRSMPDASKVERMVQTALDVWANHSKLTFREVYSDQADIQILFARRAHGDGYKFDGPGQVLAHAFYPGEGRGGDAHFDADETWNFDGESDDSHGTNFLNVALHELGHSLGLAHSAIPDAVMFPWYQNNEVAGNLPDDDRYGIQQLYGTKEKTWGPYKPQTTTTTTTTTTMRAMIYRADKPAYWPWNNPSNNPNNDRNRARERQEEERRRQEKERRRQEEERRHQEEERRRQVEERQRQEEERWRQEQERQEEENRRRKIEHKSQWERNPSKERNRPRERQEMERRRQEQERQEQERQEQEDRRRERERDRQLEWERRNRNGAREPVTPTANTTPRPTNKPYPTVHRQHHHHNKPRKPKPDSCMTYYDAISIIRGELFIFRGPYLWRIGTSGLYNGYPTEIRRHWSALPENLTKVDAVYENKQRQIVFFIGREYYVFNSVMLAPGFPKPLASLGLPPTLTHIDASFVWGHNNRTYMTSGTLYWRIDDYTGQVELDYPRDMSIWSGVGYNIDAAFQYLDGKTYFFKNLGYWEFNDDRMKVAHARAKLSARRWMQCARSANEVDDEQRWTASLVSEGEETGRSGSRELRINHFILSILLLAIANWRS", "length": 758 }, "evidence": [ { "id": "MGI:1346076", "url": "https://alliancegenome.org/gene/MGI:1346076#orthology", "database": "AGR" }, { "id": "HGNC:7163", "url": "https://alliancegenome.org/gene/HGNC:7163#orthology", "database": "AGR" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9R0S3-1", "protein_name": "Matrix metalloproteinase-17", "gene_name": "Mmp17", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGRRPRGPGSPRGPGPPRPGPGLPPLLLVLALAAHGGCAAPAPRAEDLSLGVEWLSRFGYLPPADPASGQLQTQEELSKAITAMQQFGGLETTGILDEATLALMKTPRCSLPDLPPGAQSRRKRQTPPPTKWSKRNLSWRVRTFPRDSPLGRDTVRALMYYALKVWSDITPLNFHEVAGNAADIQIDFSKADHNDGYPFDGPGGTVAHAFFPGDHHTAGDTHFDDDEPWTFRSSDAHGMDLFAVAVHEFGHAIGLSHVAAPSSIMQPYYQGPVGDPLRYGLPYEDRVRVWQLYGVRESVSPTAQLDTPEPEEPPLLPEPPNNRSSTPPQKDVPHRCTAHFDAVAQIRGEAFFFKGKYFWRLTRDRHLVSLQPAQMHRFWRGLPLHLDSVDAVYERTSDHKIVFFKGDRYWVFKDNNVEEGYPRPVSDFSLPPGGIDAVFSWAHNDRTYFFKDQLYWRYDDHTRRMDPGYPAQGPLWRGVPSMLDDAMRWSDGASYFFRGQEYWKVLDGELEAAPGYPQSTARDWLVCGEPLADAEDVGPGPQGRSGAQDGLAVCSCTSDAHRLALPSLLLLTPLLWGL", "length": 578 }, "evidence": [ { "id": "MGI:1346076", "url": "https://alliancegenome.org/gene/MGI:1346076#orthology", "database": "AGR" }, { "id": "HGNC:7163", "url": "https://alliancegenome.org/gene/HGNC:7163#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-081107-17", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-081107-17#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9ULZ9-1", "protein_name": "Matrix metalloproteinase-17", "gene_name": "MMP17", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRRRAARGPGPPPPGPGLSRLPLPLLLLLALGTRGGCAAPAPAPRAEDLSLGVEWLSRFGYLPPADPTTGQLQTQEELSKAITAMQQFGGLEATGILDEATLALMKTPRCSLPDLPVLTQARRRRQAPAPTKWNKRNLSWRVRTFPRDSPLGHDTVRALMYYALKVWSDIAPLNFHEVAGSAADIQIDFSKADHNDGYPFDGPGGTVAHAFFPGHHHTAGDTHFDDDEAWTFRSSDAHGMDLFAVAVHEFGHAIGLSHVAAAHSIMRPYYQGPVGDPLRYGLPYEDKVRVWQLYGVRESVSPTAQPEEPPLLPEPPDNRSSAPPRKDVPHRCSTHFDAVAQIRGEAFFFKGKYFWRLTRDRHLVSLQPAQMHRFWRGLPLHLDSVDAVYERTSDHKIVFFKGDRYWVFKDNNVEEGYPRPVSDFSLPPGGIDAAFSWAHNDRTYFFKDQLYWRYDDHTRHMDPGYPAQSPLWRGVPSTLDDAMRWSDGASYFFRGQEYWKVLDGELEVAPGYPQSTARDWLVCGDSQADGSVAAGVDAAEGPRAPPGQHDQSRSEDGYEVCSCTSGASSPPGAPGPLVAATMLLLLPPLSPGALWTAAQALTL", "length": 603 }, "evidence": [ { "id": "MGI:1346076", "url": "https://alliancegenome.org/gene/MGI:1346076#orthology", "database": "AGR" }, { "id": "HGNC:7163", "url": "https://alliancegenome.org/gene/HGNC:7163#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-081107-17", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-081107-17#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metalloendopeptidase activity", "id": "GO:0004222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004222", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB00", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB00" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB00", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB00" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB00", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB00" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB00", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB00" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB00", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB00" } ], "pmid": "" }, { "name": "extracellular matrix organization", "id": "GO:0030198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030198", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB00", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB00" } ], "pmid": "" }, { "name": "neural crest cell migration", "id": "GO:0001755", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001755", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB00", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB00" } ], "pmid": "" }, { "name": "collagen catabolic process", "id": "GO:0030574", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030574", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IB00", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IB00" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 353, "end_pos": 355, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.agr", "label": "AGR Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 353, "end_pos": 355 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": 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