{ "uniprot_canonical_ac": "A0A0R4IAP0-1", "uniprot_ac": "A0A0R4IAP0", "uniprot_id": "A0A0R4IAP0_DANRE", "mass": { "chemical_mass": 62824.0, "monoisotopic_mass": 62824.0 }, "refseq": { "ac": "NP_001292543", "name": "ER degradation-enhancing alpha-mannosidase-like protein 2 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292543" }, "gene_names": [ { "name": "edem2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAP0", "id": "A0A0R4IAP0" }, { "name": "edem2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292543", "id": "NP_001292543" } ], "protein_names": [ { "name": "alpha-1,2-Mannosidase", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAP0/entry#names_and_taxonomy", "id": "A0A0R4IAP0" }, { "name": "3.2.1.-", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAP0/entry#names_and_taxonomy", "id": "A0A0R4IAP0" }, { "name": "ER degradation-enhancing alpha-mannosidase-like protein 2 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292543", "id": "NP_001292543" } ], "function": [ { "annotation": "##Evidence-Data-START## Transcript exon combination :: GFIL01009155.1, BC055547.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000023.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.", "evidence": [ { "database": "RefSeq", "id": "NP_001292543", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292543" } ] }, { "annotation": "Involved in the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. May initiate ERAD by promoting the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2. Seems to recognize and bind to exposed hydrophobic regions in target proteins.", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IAP0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAP0#function" }, { "database": "UniProtKB", "id": "ARBA00054385", "url": "https://www.uniprot.org/uniprotkb/ARBA00054385#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Danio rerio", "taxid": 7955, "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IAP0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAP0" } ], "common_name": "Zebrafish", "glygen_name": "Zebrafish", "reference_species": "Danio rerio [7955]" } ], "gene": [ { "name": "edem2", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAP0", "locus": {} } ], "crossref": [ { "id": "ZFIN:ZDB-GENE-060519-1", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-060519-1", "database": "AGR", "categories": [ "Protein Classification" ] }, { "id": "ENSDARG00000028448", "url": "https://bgee.org/?page=gene&gene_id=ENSDARG00000028448", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "402801", "url": "https://www.ncbi.nlm.nih.gov/gene/402801", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001382", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001382", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012341", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012341", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036026", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036026", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044674", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044674", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dre:402801", "url": "https://www.genome.jp/dbget-bin/www_bget?dre:402801", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HNYHRVW", "url": "https://omabrowser.org/oma/group/HNYHRVW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A0R4IAP0", "url": "https://www.orthodb.org/?gene=A0A0R4IAP0", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45679", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45679", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45679:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45679:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01532", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01532", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "NP_001292543", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292543", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A0R4IAP0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAP0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0R4IAP0-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAP0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "ZDB-GENE-060519-1", "url": "https://zfin.org/ZDB-GENE-060519-1", "database": "ZFIN", "categories": [ "Protein", "Organism-specific" ] } ], "sequence": { "sequence": "MLTFLFSAIFCAAYLSPIISHVKGRDFTEQEMSHYRDRVKSMFYHAYNSYLDNAYPYDELRPLTCDGQDTWGSFSLTLIDALDTLLILGNHTEFQRVATLLQDTVDFDIDVNASVFETNIRVVGGLLSAHLLSKRAGMKVEEGWPCSGPLLRMAEDAARKLLPAFQTPTGMPYGTVNLLRGVNPGETPVTCTAGVGTFILEFSTLSRLTGDPVFENVARKALRALWRTRSDIGLVGNHIDVITSKWVAQDAGIGAGVDSYFEYLVKGAIMLQDEKLLTMFYEFDKSIKNYTKFDDWYLWVQMHKGTVSMPVFQSLEAFWPGMQSLIGDISSATKSFHNYYSVWRQFGGLPEFYSIPQGYTVDKREGYPLRPELIESAMYLYKATGDPSFIQLGRDAVESIDRISRVNCGFATVKDVRDHKLDNRMESFFLAETIKYLYLLFDPDNFLHNTGTEFELGGLRGDCILSAGGYVFNTEAHPLDPAALHCCSREQQDRREIQDILLSFSQPQTEEPPRDQNAGGSPESIALKPGEQRKAPVLSCPTQPFSAKLAVMGQVFSDNS", "length": 560, "header": "tr|A0A0R4IAP0-1|A0A0R4IAP0_DANRE Isoform 1 of alpha-1,2-Mannosidase OS=Danio rerio OX=7955 GN=edem2 PE=1 SV=1 CANONICAL=A0A0R4IAP0-1" }, "isoforms": [ { "isoform_ac": "A0A0R4IAP0-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAP0/entry#A0A0R4IAP0-1", "sequence": { "sequence": "MLTFLFSAIFCAAYLSPIISHVKGRDFTEQEMSHYRDRVKSMFYHAYNSYLDNAYPYDELRPLTCDGQDTWGSFSLTLIDALDTLLILGNHTEFQRVATLLQDTVDFDIDVNASVFETNIRVVGGLLSAHLLSKRAGMKVEEGWPCSGPLLRMAEDAARKLLPAFQTPTGMPYGTVNLLRGVNPGETPVTCTAGVGTFILEFSTLSRLTGDPVFENVARKALRALWRTRSDIGLVGNHIDVITSKWVAQDAGIGAGVDSYFEYLVKGAIMLQDEKLLTMFYEFDKSIKNYTKFDDWYLWVQMHKGTVSMPVFQSLEAFWPGMQSLIGDISSATKSFHNYYSVWRQFGGLPEFYSIPQGYTVDKREGYPLRPELIESAMYLYKATGDPSFIQLGRDAVESIDRISRVNCGFATVKDVRDHKLDNRMESFFLAETIKYLYLLFDPDNFLHNTGTEFELGGLRGDCILSAGGYVFNTEAHPLDPAALHCCSREQQDRREIQDILLSFSQPQTEEPPRDQNAGGSPESIALKPGEQRKAPVLSCPTQPFSAKLAVMGQVFSDNS", "length": 560, "header": "tr|A0A0R4IAP0-1|A0A0R4IAP0_DANRE Isoform 1 of alpha-1,2-Mannosidase OS=Danio rerio OX=7955 GN=edem2 PE=1 SV=1 CANONICAL=A0A0R4IAP0-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "The zebrafish reference genome sequence and its relationship to the human genome.", "journal": "Nature", "date": "2013", "authors": "Howe Kerstin, Clark Matthew D, Torroja Carlos F, Torrance James, Berthelot Camille, Muffato Matthieu, Collins John E, Humphray Sean, McLaren Karen, Matthews Lucy, McLaren Stuart, Sealy Ian, Caccamo Mario, Churcher Carol, Scott Carol, Barrett Jeffrey C, Koch Romke, Rauch Gerd-J\u00f6rg, White Simon, Chow William, Kilian Britt, Quintais Leonor T, Guerra-Assun\u00e7\u00e3o Jos\u00e9 A, Zhou Yi, Gu Yong, Yen Jennifer, Vogel Jan-Hinnerk, Eyre Tina, Redmond Seth, Banerjee Ruby, Chi Jianxiang, Fu Beiyuan, Langley Elizabeth, Maguire Sean F, Laird Gavin K, Lloyd David, Kenyon Emma, Donaldson Sarah, Sehra Harminder, Almeida-King Jeff, Loveland Jane, Trevanion Stephen, Jones Matt, Quail Mike, Willey Dave, Hunt Adrienne, Burton John, Sims Sarah, McLay Kirsten, Plumb Bob, Davis Joy, Clee Chris, Oliver Karen, Clark Richard, Riddle Clare, Elliot David, Eliott David, Threadgold Glen, Harden Glenn, Ware Darren, Begum Sharmin, Mortimore Beverley, Mortimer Beverly, Kerry Giselle, Heath Paul, Phillimore Benjamin, Tracey Alan, Corby Nicole, Dunn Matthew, Johnson Christopher, Wood Jonathan, Clark Susan, Pelan Sarah, Griffiths Guy, Smith Michelle, Glithero Rebecca, Howden Philip, Barker Nicholas, Lloyd Christine, Stevens Christopher, Harley Joanna, Holt Karen, Panagiotidis Georgios, Lovell Jamieson, Beasley Helen, Henderson Carl, Gordon Daria, Auger Katherine, Wright Deborah, Collins Joanna, Raisen Claire, Dyer Lauren, Leung Kenric, Robertson Lauren, Ambridge Kirsty, Leongamornlert Daniel, McGuire Sarah, Gilderthorp Ruth, Griffiths Coline, Manthravadi Deepa, Nichol Sarah, Barker Gary, Whitehead Siobhan, Kay Michael, Brown Jacqueline, Murnane Clare, Gray Emma, Humphries Matthew, Sycamore Neil, Barker Darren, Saunders David, Wallis Justene, Babbage Anne, Hammond Sian, Mashreghi-Mohammadi Maryam, Barr Lucy, Martin Sancha, Wray Paul, Ellington Andrew, Matthews Nicholas, Ellwood Matthew, Woodmansey Rebecca, Clark Graham, Cooper James D, Cooper James, Tromans Anthony, Grafham Darren, Skuce Carl, Pandian Richard, Andrews Robert, Harrison Elliot, Kimberley Andrew, Garnett Jane, Fosker Nigel, Hall Rebekah, Garner Patrick, Kelly Daniel, Bird Christine, Palmer Sophie, Gehring Ines, Berger Andrea, Dooley Christopher M, Ersan-\u00dcr\u00fcn Z\u00fcbeyde, Eser Cigdem, Geiger Horst, Geisler Maria, Karotki Lena, Kirn Anette, Konantz Judith, Konantz Martina, Oberl\u00e4nder Martina, Rudolph-Geiger Silke, Teucke Mathias, Lanz Christa, Raddatz G\u00fcnter, Osoegawa Kazutoyo, Zhu Baoli, Rapp Amanda, Widaa Sara, Langford Cordelia, Yang Fengtang, Schuster Stephan C, Carter Nigel P, Harrow Jennifer, Ning Zemin, Herrero Javier, Searle Steve M J, Enright Anton, Geisler Robert, Plasterk Ronald H A, Lee Charles, Westerfield Monte, de Jong Pieter J, Zon Leonard I, Postlethwait John H, N\u00fcsslein-Volhard Christiane, Hubbard Tim J P, Roest Crollius Hugues, Rogers Jane, Stemple Derek L", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IAP0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAP0" } ], "reference": [ { "type": "PubMed", "id": "23594743", "url": "https://glygen.org/publication/PubMed/23594743" } ] }, { "title": "Evolution and genomic organization of muscle microRNAs in fish genomes.", "journal": "BMC Evol. Biol.", "date": "2014", "authors": "Nachtigall Pedro Gabriel, Dias Marcos Correa, Pinhal Danillo", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IAP0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAP0" } ], "reference": [ { "type": "PubMed", "id": "25253178", "url": "https://glygen.org/publication/PubMed/25253178" } ] }, { "title": "RFX transcription factors are essential for hearing in mice.", "journal": "Nat. Commun.", "date": "2015", "authors": "Elkon Ran, Milon Beatrice, Morrison Laura, Shah Manan, Vijayakumar Sarath, Racherla Manoj, Leitch Carmen C, Silipino Lorna, Hadi Shadan, Weiss-Gayet Mich\u00e8le, Barras Emmanu\u00e8le, Schmid Christoph D, Ait-Lounis Aouatef, Barnes Ashley, Song Yang, Eisenman David J, Eliyahu Efrat, Frolenkov Gregory I, Strome Scott E, Durand B\u00e9n\u00e9dicte, Zaghloul Norann A, Jones Sherri M, Reith Walter, Hertzano Ronna", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IAP0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAP0" } ], "reference": [ { "type": "PubMed", "id": "26469318", "url": "https://glygen.org/publication/PubMed/26469318" } ] }, { "title": "A novel system to quantify intestinal lipid digestion and transport.", "journal": "Biochim Biophys Acta Mol Cell Biol Lipids", "date": "2018", "authors": "S\u00e6le \u00d8ystein, R\u00f8d Kari Elin L, Quinlivan Vanessa H, Li Shengrong, Farber Steven A", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IAP0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAP0" } ], "reference": [ { "type": "PubMed", "id": "29778665", "url": "https://glygen.org/publication/PubMed/29778665" } ] }, { "title": "Expression of the Z Variant of alpha1-Antitrypsin Suppresses Hepatic Cholesterol Biosynthesis in Transgenic Zebrafish.", "journal": "Int. J. Mol. Sci.", "date": "2023", "authors": "Fung Connie, Wilding Brendan, Schittenhelm Ralf B, Bryson-Richardson Robert J, Bird Phillip I", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IAP0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAP0" } ], "reference": [ { "type": "PubMed", "id": "36768797", "url": "https://glygen.org/publication/PubMed/36768797" } ] } ], "pathway": [ { "id": "dre:402801", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?dre:402801", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A480QI21-1", "protein_name": "alpha-1,2-Mannosidase", "gene_name": "EDEM2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MPFRLLVPLGLLCALLPLHHGAPGPDGTAPDPAHYRERVKAMFYHAYDSYLENAFPYDELRPLTCDGHDTWGSFSLTLIDALDTLLILGNVSEFQRVVEVLQDNVDFDIDVNASVFETNIRVVGGLLSAHLLSKKAGVEVEAGWPCSGPLLRMAEEAARKLLPAFQTPTGMPYGTVNLLHGVNPGETPVTCTAGIGTFIVEFATLSSLTGDPVFEDVARVALMRLWESRSDIGLVGNHIDVLTGKWVAQDAGIGAGVDSYFEYLVKGAILLQDKKLMAMFLEYNKAIRNYTRFDDWYLWVQMYKGTVSMPVFQSLEAYWPGLQSLIGDIDNAMRTFLNYYTVWKQFGGLPEFYNIPQGYTVEKREGYPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDLRDHKLDNRMESFFLAETVKYLYLLFDPSNFIHNNGSTFDVVITPYGECILGAGGYIFNTEAHPIDPAALHCCRRLKEEQWEVEDLMREFYSLKRNRSRFHKKSMSSGPWEPPTGPGTFSSSENHDQAREKKPAKRKIPLLSCPSRPFTSKLALLGQVFLDSS", "length": 578 }, "evidence": [ { "id": "A0A0R4IAP0", "url": "https://omabrowser.org/oma/group/A0A0R4IAP0/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A8V1A1A6-1", "protein_name": "alpha-1,2-Mannosidase", "gene_name": "EDEM2", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MALLRSLGSLLCLCAFRIPAGPGAAARGLDVASYRERVRAMFYHAYEHYLESAFPYDELRPLTCDGHDTWGSFSLTLIDALDTLLILGNVTEFQRVVAVLQEGLDFDIDVNASVFETNIRVVGGLLSAHLLSKKAGVEVEVGWPCSGPLLRLAEEAARKLLPAFQTPTGMPYGTVNLLHGVNPGETPVTCTAGIGTFIVEFATLSHLTGDPVFEDVARKALKALWKNRSDIGLVGNHIDVVTAKWVAQDAGIGAGVDSYFEYLVKGAILLQDKELMSMFLEYNKAIKNYTKFDDWYLWVQMYKGTVSMPVFQSLEAYWPGLQSLIGDVDNAMRTFLNYYTVWKQFGGLPEFYNIPQGYTVDKREGYPLRPELIESAMYLYRATRDPILLELGRDAVESIEKISKVDCGFATIKDLRDHRLDNRMESFFLAETVKYLYLLFDPDNFIHNDGSDFDVVITPYGECILNAGGYVFNTEAHPIDPAALHCCRKRKEEQWEVEDLMQEFYSLQKKKKFPLKQTSDCAEGGCAKDPAGASLGGKKRNSKKSSHSLLSCPSQSFNSKLAVLGQVFLDNT", "length": 572 }, "evidence": [ { "id": "A0A0R4IAP0", "url": "https://omabrowser.org/oma/group/A0A0R4IAP0/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "A6KI53-1", "protein_name": "alpha-1,2-Mannosidase", "gene_name": "Edem2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPFRLLIPLGLVCVLLPLHHGAPGPEGTAPDPAHYRERVKAMFYHAYDSYLENAFPYDELRPLTCDGHDTWGSFSLTLIDALDTLLILGNTSEFQRVVEVLQDNVDFDIDVNASVFETNIRVVGGLLSAHLLSKKAGVEVEAGWPCSGPLLRMAEEAARKLLPAFQTPTGMPYGTVNLLHGVNPGETPVTCTAGIGTFIVEFATLSSLTGDPVFEDVARVALMRLWESRSDIGLVGNHIDVLTGKWVAQDAGIGAGVDSYFEYLVKGAILLQDKKLMAMFLEYNKAIRNYTHFDDWYLWVQMYKGTVSMPVFQSLEAYWPGLQSLIGDIDNAMRTFLNYYTVWKQFGGLPEFYNIPQGYTVEKREGYPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDLRDHKLDNRMESFFLAETVKYLYLLFHPNNFIHNNGSTFDSVMTPHGECILGAGGYIFNTEAHPIDPAALHCCRRLKEEQWEVEDLIKEFYSLRQSRSRAQRKTVSSGPWEPPAGPGTLSSPENQPREKQPARQRAPLLSCPSQPFTSKLALLGQVFLDSS", "length": 576 }, "evidence": [ { "id": "HGNC:15877", "url": "https://alliancegenome.org/gene/HGNC:15877#orthology", "database": "AGR" }, { "id": "MGI:1915540", "url": "https://alliancegenome.org/gene/MGI:1915540#orthology", "database": "AGR" }, { "id": "A0A0R4IAP0", "url": "https://omabrowser.org/oma/group/A0A0R4IAP0/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "M9PG98-1", "protein_name": "alpha-1,2-Mannosidase", "gene_name": "Edem1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MQQKPRNNGYPGTLICAVLLVLLSTGVSGQKQYSKARKLELREDVRRMFQHAYDGYLRHASNYDELRPLTCDGHDTWGSYSLTLIDALDTLATMGNFTEFRRAARLLEEKMDFDRDINVSVFETNIRIVGGLLSAHLLSKRAGVELEPGWPCKGPLLRLAEDVARRLLPAFVTNTGMPYGTVNLRYGVPKGETSITCTAGVGTFLIEFGTLSRLTGKTIYEDVAMKAVHALWAYRSPIGLFGNHIDVQSGRWTALDSGIGAGVDSLFEYLVKASVLLNRPELLELFHEARAAIDKYMRKEDWYVWVGMNKGRVTLPVFQSLEAFWPGILSIIGDTEPALRTISRYIGVWKKYGFLPEFYNIAAGEASPNREVYPLRPELIESAMYLYRATGNEYLLEFGEHMLETLEFSAKTKCGYATIRNVVTHEKENRMESFFLAETSKYLYLLFDEENFLHNDGSGGELLSTEDDVCVVQAGAYIFNTEAHPMDMSALHCCHAHNEDIYTSLDLQRFSPRAILERSKKRQVAVQEQWVPQCHPENNEFFNKEDESVQAQDSEKEQEREQSGTSTTMAVDIEVFDEFQQPAGDLLVSNFEQIREERELNESLHRNVVARNQLTVSDLDEFFAQRRESFASASEALNYVKTFMGNYTMDVAFIRGLQLYDTNMSSVLGTGAQKEYESRMRTLWQLYELQQQYVANIRVIQGLGLLTFPADGDRIPSHLTEVLDSLDKSAHLEHMDLQDLETRVSNTSSPQLAHIREVILKARNAYAIAMVNTSAMQEFAIRIYLSGTSEAGVRIHPLLEDGELSEEARKRPLKLAEERALFSYARRIVDFRKRMAETVDRLQTLMQDIPPPKRKEATTDSQAADASTVYTQTKAQMAAPAQQPEPSQEEKQSTQIQKGKLAENGSGLGEEESGCVWSQLVQTILRKTTVQRVKFDEAVLQENTRKALEKYARKELPHHLFACHRPEYIEGFAYRDFYPEALKVRRRCAHDNERLNCRAKRTER", "length": 1004 }, "evidence": [ { "id": "HGNC:15877", "url": "https://alliancegenome.org/gene/HGNC:15877#orthology", "database": "AGR" }, { "id": "MGI:1915540", "url": "https://alliancegenome.org/gene/MGI:1915540#orthology", "database": "AGR" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q8BJT9-1", "protein_name": "ER degradation-enhancing alpha-mannosidase-like protein 2", "gene_name": "Edem2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPFRLLIPLGLVCVLLPLHHGAPGPDGTAPDPAHYRERVKAMFYHAYDSYLENAFPYDELRPLTCDGHDTWGSFSLTLIDALDTLLILGNTSEFQRVVEVLQDNVDFDIDVNASVFETNIRVVGGLLSAHLLSKKAGVEVEAGWPCSGPLLRMAEEAARKLLPAFQTPTGMPYGTVNLLHGVNPGETPVTCTAGIGTFIVEFATLSSLTGDPVFEDVARVALMRLWESRSDIGLVGNHIDVLTGKWVAQDAGIGAGVDSYFEYLVKGAILLQDKKLMAMFLEYNKAIRNYTHFDDWYLWVQMYKGTVSMPVFQSLEAYWPGLQSLIGDIDNAMRTFLNYYTVWKQFGGLPEFYNIPQGYTVEKREGYPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDLRDHKLDNRMESFFLAETVKYLYLLFHPNNFIHNNGSTFDSVMTPHGECILGAGGYIFNTEAHPIDPAALHCCRRLKEEQWEVEDLIKEFYSLKQSRPKRAQRKTVRSGPWEPQSGPATLSSPANQPREKQPAQQRTPLLSCPSQPFTSKLALLGQVFLDSS", "length": 577 }, "evidence": [ { "id": "HGNC:15877", "url": "https://alliancegenome.org/gene/HGNC:15877#orthology", "database": "AGR" }, { "id": "MGI:1915540", "url": "https://alliancegenome.org/gene/MGI:1915540#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-060519-1", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-060519-1#orthology", "database": "AGR" }, { "id": "A0A0R4IAP0", "url": "https://omabrowser.org/oma/group/A0A0R4IAP0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BV94-1", "protein_name": "ER degradation-enhancing alpha-mannosidase-like protein 2", "gene_name": "EDEM2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPFRLLIPLGLLCALLPQHHGAPGPDGSAPDPAHYRERVKAMFYHAYDSYLENAFPFDELRPLTCDGHDTWGSFSLTLIDALDTLLILGNVSEFQRVVEVLQDSVDFDIDVNASVFETNIRVVGGLLSAHLLSKKAGVEVEAGWPCSGPLLRMAEEAARKLLPAFQTPTGMPYGTVNLLHGVNPGETPVTCTAGIGTFIVEFATLSSLTGDPVFEDVARVALMRLWESRSDIGLVGNHIDVLTGKWVAQDAGIGAGVDSYFEYLVKGAILLQDKKLMAMFLEYNKAIRNYTRFDDWYLWVQMYKGTVSMPVFQSLEAYWPGLQSLIGDIDNAMRTFLNYYTVWKQFGGLPEFYNIPQGYTVEKREGYPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDLRDHKLDNRMESFFLAETVKYLYLLFDPTNFIHNNGSTFDAVITPYGECILGAGGYIFNTEAHPIDPAALHCCQRLKEEQWEVEDLMREFYSLKRSRSKFQKNTVSSGPWEPPARPGTLFSPENHDQARERKPAKQKVPLLSCPSQPFTSKLALLGQVFLDSS", "length": 578 }, "evidence": [ { "id": "HGNC:15877", "url": "https://alliancegenome.org/gene/HGNC:15877#orthology", "database": "AGR" }, { "id": "MGI:1915540", "url": "https://alliancegenome.org/gene/MGI:1915540#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-060519-1", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-060519-1#orthology", "database": "AGR" }, { "id": "A0A0R4IAP0", "url": "https://omabrowser.org/oma/group/A0A0R4IAP0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9FG93-1", "protein_name": "Alpha-mannosidase I MNS4", "gene_name": "MNS4", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MDSNFKWLLFAILISLTFSGFVLHHGVLAESVKPDEAKQLRDEVRGMFYHAFDGYMNNAFPLDELRPLSCQGEDTLGGYALTLIDSLDTLALLGDRERFTSSVEWIGKNLQFNINKTVSVFETTIRVLGGLLSAHLIASDYATGMRIPSYNNELLVLAENLARRMLPAFDTPTGIPFGSVNLMYGVDKHESKITSTAGGGTLSLEFGVLSRLTNDPVFEQVAKNAVRGLWARRSNLDLVGAHINVFTGEWTQKDAGIGTSIDSFYEYLLKAYILFGDEEYLYIFQEAYRSAMQYLHKDPWYVEVNMDSAAIVWPVFNSLQAFWPGLQVLAGDVDPAIRTHTAFFSVWKRYGFTPEGFNLATLSVQYGQKSYPLRPELIESTYWLYKATRDPRYLDAGRDFVASLQYGAKCPCGYCHITDVELHKQEDHMESFFLAETVKYLWLLFDLAVDSDNLVDNGPYKYIFSTEGHLLPITPQISLAREHCSYFGGYCPSNSTKLEQEVLGEDSSNDDHSNDYPYHESFPVTGLIKGLCPGLTHAQKYGFSYVLPEKTDREDVNQPKPVVTSSSIVLISDQTVEKRPQEEEGFTSQSEPIMTISGGSSNDQTGQELTLLESETDDQRSYSS", "length": 624 }, "evidence": [ { "id": "A0A0R4IAP0", "url": "https://omabrowser.org/oma/group/A0A0R4IAP0/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IAP0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAP0" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IAP0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAP0" } ], "pmid": "" }, { "name": "endoplasmic reticulum quality control compartment", "id": "GO:0044322", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044322", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IAP0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAP0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "carbohydrate metabolic process", "id": "GO:0005975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005975", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IAP0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAP0" } ], "pmid": "" }, { "name": "endoplasmic reticulum unfolded protein response", "id": "GO:0030968", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030968", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IAP0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAP0" } ], "pmid": "" }, { "name": "endoplasmic reticulum mannose trimming", "id": "GO:1904380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904380", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IAP0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAP0" } ], "pmid": "" }, { "name": "ubiquitin-dependent glycoprotein ERAD pathway", "id": "GO:0097466", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097466", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IAP0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAP0" } ], "pmid": "" }, { "name": "mannoprotein catabolic process", "id": "GO:0006058", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006058", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IAP0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAP0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IAP0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAP0" } ], "pmid": "" }, { "name": "mannosyl-oligosaccharide 1,2-alpha-mannosidase activity", "id": "GO:0004571", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004571", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IAP0", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAP0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 112, "end_pos": 114, "annotation": "n_glycosylation_sequon" }, { "start_pos": 289, "end_pos": 291, "annotation": "n_glycosylation_sequon" }, { "start_pos": 90, "end_pos": 92, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], 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