{ "uniprot_canonical_ac": "A0A0R4IAF6-1", "uniprot_ac": "A0A0R4IAF6", "uniprot_id": "A0A0R4IAF6_DANRE", "mass": { "chemical_mass": 216009.0, "monoisotopic_mass": 216009.0 }, "refseq": { "ac": "NP_001410925", "name": "proteasome activator complex subunit 4A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410925" }, "gene_names": [ { "name": "psme4a", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAF6", "id": "A0A0R4IAF6" }, { "name": "psme4a", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410925", "id": "NP_001410925" }, { "name": "si:ch73-101f17.1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410925", "id": "NP_001410925" }, { "name": "si:ch73-101f17.1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAF6", "id": "A0A0R4IAF6" } ], "protein_names": [ { "name": "Proteasome activator complex subunit 4A", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAF6/entry#names_and_taxonomy", "id": "A0A0R4IAF6" }, { "name": "proteasome activator PA200-A; proteasome (prosome, macropain) activator subunit 4a", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410925", "id": "NP_001410925" }, { "name": "proteasome activator complex subunit 4A", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410925", "id": "NP_001410925" } ], "function": [ { "annotation": "##Evidence-Data-START## Transcript exon combination :: GFIL01018484.1, SRR32588733.1803133.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505392, SAMEA4476757 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000013.1. On Aug 28, 2023 this sequence version replaced XP_009305766.1.", "evidence": [ { "database": "RefSeq", "id": "NP_001410925", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410925" } ] }, { "annotation": "Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. involved in DNA damage response in somatic cells: binds to acetylated histones and promotes degradation of histones.", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IAF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAF6#function" }, { "database": "UniProtKB", "id": "ARBA00056104", "url": "https://www.uniprot.org/uniprotkb/ARBA00056104#function" }, { "database": "UniProtKB", "id": "A0A8M3BET6", "url": "https://www.uniprot.org/uniprotkb/A0A8M3BET6#function" } ] } ], "disease": [ { "disease_id": "DOID:0050545", "recommended_name": { "id": "DOID:0050545", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050545", "name": "visceral heterotaxy", "description": "A physical disorder characterized by the abnormal distribution of the major visceral organs within the chest and abdomen." }, "synonyms": [ { "id": "DOID:0050545", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050545", "name": "heterotaxia", "description": "" }, { "id": "DOID:0050545", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050545", "name": "situs ambiguus", "description": "" }, { "id": "MONDO:0010607", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010607", "name": "heterotaxy, visceral, 1, X-linked", "description": "X-linked visceral heterotaxy type 1 is a very rare form of heterotaxy that has only been reported in a few families. Heterotaxy is the right/left transposition of thoracic and/or abdominal organs. This condition is caused by mutations in the ZIC3 gene, is inherited in an X-linked recessive fashion, and is usually seen in males. Physical features include heart abnormalities such as dextrocardia, transposition of great vessels, ventricular septal defect, patent ductus arteriosus, pulmonic stenosis ; situs inversus, and missing (asplenia) and/or extra spleens (polysplenia).Affected individualscan also experience abnormalities in the development of the midline of the body, which can cause holoprosencephaly, myelomeningocele, urological anomalies, widely spaced eyes (hypertelorism), cleft palate, and abnormalities of the sacral spine and anus. Heterotaxia with recurrent respiratory infections are called primary ciliary dyskinesia." }, { "id": "MONDO:0010607", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010607", "name": "ZIC3 visceral heterotaxy", "description": "" }, { "id": "MONDO:0010607", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010607", "name": "congenital heart defects, nonsyndromic, 1, X-linked, X-linked recessive", "description": "" }, { "id": "MONDO:0010607", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010607", "name": "heterotaxy, visceral, 1, X-linked", "description": "" }, { "id": "MONDO:0010607", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010607", "name": "heterotaxy, visceral, 1, X-linked, X-linked recessive", "description": "" }, { "id": "MONDO:0010607", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010607", "name": "visceral heterotaxy caused by mutation in ZIC3", "description": "" }, { "id": "MONDO:0010607", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010607", "name": "HTX1", "description": "" }, { "id": "MONDO:0010607", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010607", "name": "X-linked visceral heterotaxy 1", "description": "" }, { "id": "MONDO:0010607", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010607", "name": "congenital heart defects, multiple types, 1, X-linked", "description": "" }, { "id": "MONDO:0010607", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010607", "name": "dextrocardia with Other Cardiac malformations", "description": "" }, { "id": "MONDO:0010607", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010607", "name": "heterotaxy, visceral, X-linked", "description": "" }, { "id": "MONDO:0010607", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010607", "name": "laterality, X-linked", "description": "" }, { "id": "MONDO:0010607", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010607", "name": "situs inversus, Complex Cardiac defects, and splenic defects, X-linked", "description": "" }, { "id": "MIM:306955", "resource": "MIM", "url": "https://www.omim.org/entry/306955", "name": "Heterotaxy, visceral, 1, X-linked", "description": "Heterotaxy, visceral, 1, X-linked" } ], "unlinked_id_list": [], "evidence": [ { "id": "0050545", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050545" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Danio rerio", "taxid": 7955, "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IAF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAF6" } ], "common_name": "Zebrafish", "glygen_name": "Zebrafish", "reference_species": "Danio rerio [7955]" } ], "gene": [ { "name": "psme4a", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAF6", "locus": {} } ], "crossref": [ { "id": "ZFIN:ZDB-GENE-091204-452", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-091204-452", "database": "AGR", "categories": [ "Protein Classification" ] }, { "id": "ENSDARG00000087911", "url": "https://bgee.org/?page=gene&gene_id=ENSDARG00000087911", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "793897", "url": "https://www.ncbi.nlm.nih.gov/gene/793897", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021843", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021843", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032430", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032430", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035309", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035309", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055455", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055455", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dre:793897", "url": "https://www.genome.jp/dbget-bin/www_bget?dre:793897", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "PYTRTWD", "url": "https://omabrowser.org/oma/group/PYTRTWD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A0R4IAF6", "url": "https://www.orthodb.org/?gene=A0A0R4IAF6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "A0A8M3BET6", "url": "https://www.orthodb.org/?gene=A0A8M3BET6", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR32170", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32170", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR32170:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32170:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF11919", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF11919", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF16507", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16507", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF23096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF23096", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "NP_001410925", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410925", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A0R4IAF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAF6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0R4IAF6-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAF6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8M3BET6", "url": "https://www.uniprot.org/uniprotkb/A0A8M3BET6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8M3BET6-1", "url": "https://www.uniprot.org/uniprotkb/A0A8M3BET6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "ZDB-GENE-091204-452", "url": "https://zfin.org/ZDB-GENE-091204-452", "database": "ZFIN", "categories": [ "Protein", "Organism-specific" ] } ], "sequence": { "sequence": "MTVSNIIEVEEPELENCNVKMKKEASELLGFSPQKDIVYNELLPYKDKLDDESNEILAQIKGNLGRAVQLREVWPGVLFWTRKLSTYIRLYGRKFNKEDHVLFVKLLYELVTIPKLEISMMQSFARLLITLLKKKELLSREDLELPWRPLYELQDRILYSKTEHLGLNWFPSSLRPRSSSKHIIVKLAQRCSVEAVLKVLIKSCRPYFPESATQEMLDEWKPLMCPFDVTMQKAMGYFELFLPTTLPPELHDKGFKLWFDDLISLWVSVQNLPSWEVNLVSLFARLANDNIGYIDWDPYIPKIFTRILRSLNLPVGSSQMLVSRYLTNAYDISYVVIWISALLGGPSKQAQTQLSGLFNGITSFFHPSNHGRWLMKLMKLLQRLPASVVKRLHRERYRTPTWLTPIPESHLLSEQDITDFVESIKQPVLLAMFSKTGSLDAAQALQNLALLRPELVIPPVLEKTYPAMETLIEPHQLTATLSCMIGVARSLVAGGQRFPEGPKHMLPLLMRALPGVDPNDFSKCMITFQFLATFVTLVPLVDCSSAIHSRNGLTQVEKELCSASAEFEHFVLQFVDRCFALIDTSTLEQTREEMEMEKMTHLESLVELGLSSTFSTILTQCSMEIFQVALDKVFNFATTSIFETHVAGRMVADMCRATTKCHPAEALKLFLPHCCSAILQIAANEEVLNEEELDKELMWNLQLLSEVVRVDGDQLLLYRSQLVQILQLTLHLKCKQGYSLACKLLYHILRSMSLIYPREYCSIPGGIQQHTDTYLPIQDWGRPGELWNLEIQWHVPSTEETEFVFYLLDLLLKPELQRLQKHTEGQQDISRDDVLQSLSIVHNCFLGASSLLPPLHGEPVPQLINGMVQLYETKVYTGVDYDMSRENYREDICKVIRPLLNHTLEHSEDDIKSLFSIIKIINDLLHFKGSHKNEFDTRWKSFNLIKKSMENRLHGSKQHIRALLIDRVMLQHELRNLTMEGCSYRSVHQDLINDLLRLSTSRYSQVRCRAQNVLFTALGTYNFCCRDIIPVVLKYLDPERTDVTQQQFKGALYCLLGNHSGICLANLQYWDCIALTWPALVRSGMSPSMSLEKTSIVRLFDDLADKIHRQYETISVNFSIPESCVEIAVKMLKSSSPEPNPGAASEQEELEGRKREEQKNKDAMQKYEKLVADLLDCLHDRNIPWKFEQLTIGFLSLMLRDDLPLPSSAVLFFVESLNHDSLLVRNVAISAVAGILKQLKRPHKKVAVSPYDISELKTSLQSRDGKAVVSLLTGDRPDNQWLQYDSSRLPRSQRDWDECCFIEKTHWGYSTWPRKLMLYAPLEEQPKQGQTREEMNEREQIIYDHFSDQLFIDQFIQYLSLEDRKGKDKFSPRRFCLFKGLFRNFDDAFLPLLKPHMERLVADSHESPQRCVAEIISGLIRGSKHWSYSKVEKLWALLCPLLRKALSNITIETYIDWGTCIATACESRDPRKLHWLFEMLMESPVTGEGGSFVDACRLYVLQGGLAQQEWRVPELLHRLLQYLEPKLTQVYKNVRERIGSVLTYIFMIDVDLPYTQPTTSPRIREFTERVLARLKPLTEGEEEIQNHIVEENMEGDQDERTQAIKLLKTVLKWLMTSAGRSFSSSVPEQLRLLPLLFKIAPVENDDSYDEMKTDAKTCLSLMSQGLLYSDQIPQVLSALEEISRSSSWHARYTILTYLQIMVFYNLFTFLSDAKAVCDVRALVLRLLEDEQLEVREMAATTLSGFLQCNFLSIDEPMQAHFESLSKTRLPKRKRRELGSVVDTIPSADLVRRHAGVLGLSACILSSPYDVPTWMPQILMDLSAHLNDTQPIEMTVKKTLSDFRRTHHDNWQEHKQKFTDDQLLVLTDLLVSPCYYA", "length": 1876, "header": "tr|A0A0R4IAF6-1|A0A0R4IAF6_DANRE Isoform 1 of Proteasome activator complex subunit 4A OS=Danio rerio OX=7955 GN=psme4a PE=3 SV=1 CANONICAL=A0A0R4IAF6-1" }, "isoforms": [ { "isoform_ac": "A0A0R4IAF6-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAF6/entry#A0A0R4IAF6-1", "sequence": { "sequence": "MTVSNIIEVEEPELENCNVKMKKEASELLGFSPQKDIVYNELLPYKDKLDDESNEILAQIKGNLGRAVQLREVWPGVLFWTRKLSTYIRLYGRKFNKEDHVLFVKLLYELVTIPKLEISMMQSFARLLITLLKKKELLSREDLELPWRPLYELQDRILYSKTEHLGLNWFPSSLRPRSSSKHIIVKLAQRCSVEAVLKVLIKSCRPYFPESATQEMLDEWKPLMCPFDVTMQKAMGYFELFLPTTLPPELHDKGFKLWFDDLISLWVSVQNLPSWEVNLVSLFARLANDNIGYIDWDPYIPKIFTRILRSLNLPVGSSQMLVSRYLTNAYDISYVVIWISALLGGPSKQAQTQLSGLFNGITSFFHPSNHGRWLMKLMKLLQRLPASVVKRLHRERYRTPTWLTPIPESHLLSEQDITDFVESIKQPVLLAMFSKTGSLDAAQALQNLALLRPELVIPPVLEKTYPAMETLIEPHQLTATLSCMIGVARSLVAGGQRFPEGPKHMLPLLMRALPGVDPNDFSKCMITFQFLATFVTLVPLVDCSSAIHSRNGLTQVEKELCSASAEFEHFVLQFVDRCFALIDTSTLEQTREEMEMEKMTHLESLVELGLSSTFSTILTQCSMEIFQVALDKVFNFATTSIFETHVAGRMVADMCRATTKCHPAEALKLFLPHCCSAILQIAANEEVLNEEELDKELMWNLQLLSEVVRVDGDQLLLYRSQLVQILQLTLHLKCKQGYSLACKLLYHILRSMSLIYPREYCSIPGGIQQHTDTYLPIQDWGRPGELWNLEIQWHVPSTEETEFVFYLLDLLLKPELQRLQKHTEGQQDISRDDVLQSLSIVHNCFLGASSLLPPLHGEPVPQLINGMVQLYETKVYTGVDYDMSRENYREDICKVIRPLLNHTLEHSEDDIKSLFSIIKIINDLLHFKGSHKNEFDTRWKSFNLIKKSMENRLHGSKQHIRALLIDRVMLQHELRNLTMEGCSYRSVHQDLINDLLRLSTSRYSQVRCRAQNVLFTALGTYNFCCRDIIPVVLKYLDPERTDVTQQQFKGALYCLLGNHSGICLANLQYWDCIALTWPALVRSGMSPSMSLEKTSIVRLFDDLADKIHRQYETISVNFSIPESCVEIAVKMLKSSSPEPNPGAASEQEELEGRKREEQKNKDAMQKYEKLVADLLDCLHDRNIPWKFEQLTIGFLSLMLRDDLPLPSSAVLFFVESLNHDSLLVRNVAISAVAGILKQLKRPHKKVAVSPYDISELKTSLQSRDGKAVVSLLTGDRPDNQWLQYDSSRLPRSQRDWDECCFIEKTHWGYSTWPRKLMLYAPLEEQPKQGQTREEMNEREQIIYDHFSDQLFIDQFIQYLSLEDRKGKDKFSPRRFCLFKGLFRNFDDAFLPLLKPHMERLVADSHESPQRCVAEIISGLIRGSKHWSYSKVEKLWALLCPLLRKALSNITIETYIDWGTCIATACESRDPRKLHWLFEMLMESPVTGEGGSFVDACRLYVLQGGLAQQEWRVPELLHRLLQYLEPKLTQVYKNVRERIGSVLTYIFMIDVDLPYTQPTTSPRIREFTERVLARLKPLTEGEEEIQNHIVEENMEGDQDERTQAIKLLKTVLKWLMTSAGRSFSSSVPEQLRLLPLLFKIAPVENDDSYDEMKTDAKTCLSLMSQGLLYSDQIPQVLSALEEISRSSSWHARYTILTYLQIMVFYNLFTFLSDAKAVCDVRALVLRLLEDEQLEVREMAATTLSGFLQCNFLSIDEPMQAHFESLSKTRLPKRKRRELGSVVDTIPSADLVRRHAGVLGLSACILSSPYDVPTWMPQILMDLSAHLNDTQPIEMTVKKTLSDFRRTHHDNWQEHKQKFTDDQLLVLTDLLVSPCYYA", "length": 1876, "header": "tr|A0A0R4IAF6-1|A0A0R4IAF6_DANRE Isoform 1 of Proteasome activator complex subunit 4A OS=Danio rerio OX=7955 GN=psme4a PE=3 SV=1 CANONICAL=A0A0R4IAF6-1" }, "locus": {} }, { "isoform_ac": "A0A8M3BET6-1", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAF6/entry#A0A8M3BET6-1", "sequence": { "sequence": "MTVSNIIEVEEPELENCNVKMKKEASELLGFSPQKDIVYNELLPYKDKLDDESNEILAQIKGNLGRAVQLREVWPGVLFWTRKLSTYIRLYGRKFNKEDHVLFVKLLYELVTIPKLEISMMQSFARLLITLLKKKELLSREDLELPWRPLYELQDRILYSKTEHLGLNWFPSSVEAVLKVLIKSCRPYFPESATQEMLDEWKPLMCPFDVTMQKAMGYFELFLPTTLPPELHDKGFKLWFDDLISLWVSVQNLPSWEVNLVSLFARLANDNIGYIDWDPYIPKIFTRILRSLNLPVGSSQMLVSRYLTNAYDISYVVIWISALLGGPSKQAQTQLSGLFNGITSFFHPSNHGRWLMKLMKLLQRLPASVVKRLHRERYRTPTWLTPIPESHLLSEQDITDFVESIKQPVLLAMFSKTGSLDAAQALQNLALLRPELVIPPVLEKTYPAMETLIEPHQLTATLSCMIGVARSLVAGGQRFPEGPKHMLPLLMRALPGVDPNDFSKCMITFQFLATFVTLVPLVDCSSAIHSRNGLTQVEKELCSASAEFEHFVLQFVDRCFALIDTSTLEQTREEMEMEKMTHLESLVELGLSSTFSTILTQCSMEIFQVALDKVFNFATTSIFETHVAGRMVADMCRATTKCHPAEALKLFLPHCCSAILQIAANEEVLNEEELDKELMWNLQLLSEVVRVDGDQLLLYRSQLVQILQLTLHLKCKQGYSLACKLLYHILRSMSLIYPREYCSIPGGIQQHTDTYLPIQDWGRPGELWNLEIQWHVPSTEETEFVFYLLDLLLKPELQRLQKHTEGQQDISRDDVLQSLSIVHNCFLGASSLLPPLHGEPVPQLINGMVQLYETKVYTGVDYDMSRENYREDICKVIRPLLNHTLEHSEDDIKSLFSIIKIINDLLHFKGSHKNEFDTRWKSFNLIKKSMENRLHGSKQHIRALLIDRVMLQHELRNLTMEGCSYRSVHQDLINDLLRLSTSRYSQVRCRAQNVLFTALGTYNFCCRDIIPVVLKYLDPERTDVTQQQFKGALYCLLGNHSGICLANLQYWDCIALTWPALVRSGMSPSMSLEKTSIVRLFDDLADKIHRQYETISVNFSIPESCVEIAVKMLKSSSPEPNPGAASEQEELEGRKREEQKNKDAMQKYEKLVADLLDCLHDRNIPWKFEQLTIGFLSLMLRDDLPLPSSAVLFFVESLNHDSLLVRNVAISAVAGILKQLKRPHKKVAVSPYDISELKTSLQSRDGKAVVSLLTGDRPDNQWLQYDSSRLPRSQRDWDECCFIEKTHWGYSTWPRKLMLYAPLEEQPKQGQTREEMNEREQIIYDHFSDQLFIDQFIQYLSLEDRKGKDKFSPRRFCLFKGLFRNFDDAFLPLLKPHMERLVADSHESPQRCVAEIISGLIRGSKHWSYSKVEKLWALLCPLLRKALSNITIETYIDWGTCIATACESRDPRKLHWLFEMLMESPVTGEGGSFVDACRLYVLQGGLAQQEWRVPELLHRLLQYLEPKLTQVYKNVRERIGSVLTYIFMIDVDLPYTQPTTSPRIREFTERVLARLKPLTEGEEEIQNHIVEENMEGDQDERTQAIKLLKTVLKWLMTSAGRSFSSSVPEQLRLLPLLFKIAPVENDDSYDEMKTDAKTCLSLMSQGLLYSDQIPQVLSALEEISRSSSWHARYTILTYLQIMVFYNLFTFLSDAKAVCDVRALVLRLLEDEQLEVREMAATTLSGFLQCNFLSIDEPMQAHFESLSKTRLPKRKRRELGSVVDTIPSADLVRRHAGVLGLSACILSSPYDVPTWMPQILMDLSAHLNDTQPIEMTVKKTLSDFRRTHHDNWQEHKQKFTDDQLLVLTDLLVSPCYYA", "length": 1857, "header": "tr|A0A8M3BET6-1|A0A8M3BET6_DANRE Computationally mapped isoform of Proteasome activator complex subunit 4A isoform X1 OS=Danio rerio OX=7955 GN=psme4a PE=3 SV=1 CANONICAL=A0A0R4IAF6-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "The zebrafish reference genome sequence and its relationship to the human genome.", "journal": "Nature", "date": "2013", "authors": "Howe Kerstin, Clark Matthew D, Torroja Carlos F, Torrance James, Berthelot Camille, Muffato Matthieu, Collins John E, Humphray Sean, McLaren Karen, Matthews Lucy, McLaren Stuart, Sealy Ian, Caccamo Mario, Churcher Carol, Scott Carol, Barrett Jeffrey C, Koch Romke, Rauch Gerd-J\u00f6rg, White Simon, Chow William, Kilian Britt, Quintais Leonor T, Guerra-Assun\u00e7\u00e3o Jos\u00e9 A, Zhou Yi, Gu Yong, Yen Jennifer, Vogel Jan-Hinnerk, Eyre Tina, Redmond Seth, Banerjee Ruby, Chi Jianxiang, Fu Beiyuan, Langley Elizabeth, Maguire Sean F, Laird Gavin K, Lloyd David, Kenyon Emma, Donaldson Sarah, Sehra Harminder, Almeida-King Jeff, Loveland Jane, Trevanion Stephen, Jones Matt, Quail Mike, Willey Dave, Hunt Adrienne, Burton John, Sims Sarah, McLay Kirsten, Plumb Bob, Davis Joy, Clee Chris, Oliver Karen, Clark Richard, Riddle Clare, Elliot David, Eliott David, Threadgold Glen, Harden Glenn, Ware Darren, Begum Sharmin, Mortimore Beverley, Mortimer Beverly, Kerry Giselle, Heath Paul, Phillimore Benjamin, Tracey Alan, Corby Nicole, Dunn Matthew, Johnson Christopher, Wood Jonathan, Clark Susan, Pelan Sarah, Griffiths Guy, Smith Michelle, Glithero Rebecca, Howden Philip, Barker Nicholas, Lloyd Christine, Stevens Christopher, Harley Joanna, Holt Karen, Panagiotidis Georgios, Lovell Jamieson, Beasley Helen, Henderson Carl, Gordon Daria, Auger Katherine, Wright Deborah, Collins Joanna, Raisen Claire, Dyer Lauren, Leung Kenric, Robertson Lauren, Ambridge Kirsty, Leongamornlert Daniel, McGuire Sarah, Gilderthorp Ruth, Griffiths Coline, Manthravadi Deepa, Nichol Sarah, Barker Gary, Whitehead Siobhan, Kay Michael, Brown Jacqueline, Murnane Clare, Gray Emma, Humphries Matthew, Sycamore Neil, Barker Darren, Saunders David, Wallis Justene, Babbage Anne, Hammond Sian, Mashreghi-Mohammadi Maryam, Barr Lucy, Martin Sancha, Wray Paul, Ellington Andrew, Matthews Nicholas, Ellwood Matthew, Woodmansey Rebecca, Clark Graham, Cooper James D, Cooper James, Tromans Anthony, Grafham Darren, Skuce Carl, Pandian Richard, Andrews Robert, Harrison Elliot, Kimberley Andrew, Garnett Jane, Fosker Nigel, Hall Rebekah, Garner Patrick, Kelly Daniel, Bird Christine, Palmer Sophie, Gehring Ines, Berger Andrea, Dooley Christopher M, Ersan-\u00dcr\u00fcn Z\u00fcbeyde, Eser Cigdem, Geiger Horst, Geisler Maria, Karotki Lena, Kirn Anette, Konantz Judith, Konantz Martina, Oberl\u00e4nder Martina, Rudolph-Geiger Silke, Teucke Mathias, Lanz Christa, Raddatz G\u00fcnter, Osoegawa Kazutoyo, Zhu Baoli, Rapp Amanda, Widaa Sara, Langford Cordelia, Yang Fengtang, Schuster Stephan C, Carter Nigel P, Harrow Jennifer, Ning Zemin, Herrero Javier, Searle Steve M J, Enright Anton, Geisler Robert, Plasterk Ronald H A, Lee Charles, Westerfield Monte, de Jong Pieter J, Zon Leonard I, Postlethwait John H, N\u00fcsslein-Volhard Christiane, Hubbard Tim J P, Roest Crollius Hugues, Rogers Jane, Stemple Derek L", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IAF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAF6" } ], "reference": [ { "type": "PubMed", "id": "23594743", "url": "https://glygen.org/publication/PubMed/23594743" } ] }, { "title": "Demonstration of the Coexistence of Duplicated LH Receptors in Teleosts, and Their Origin in Ancestral Actinopterygians.", "journal": "PLoS ONE", "date": "2015", "authors": "Maugars Gersende, Dufour Sylvie", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IAF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAF6" } ], "reference": [ { "type": "PubMed", "id": "26271038", "url": "https://glygen.org/publication/PubMed/26271038" } ] }, { "title": "Klf9 is a key feedforward regulator of the transcriptomic response to glucocorticoid receptor activity.", "journal": "Sci. Rep.", "date": "2020", "authors": "Gans Ian, Hartig Ellen I, Zhu Shusen, Tilden Andrea R, Hutchins Lucie N, Maki Nathaniel J, Graber Joel H, Coffman James A", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IAF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAF6" } ], "reference": [ { "type": "PubMed", "id": "32651405", "url": "https://glygen.org/publication/PubMed/32651405" } ] }, { "title": "Expression of the Z Variant of alpha1-Antitrypsin Suppresses Hepatic Cholesterol Biosynthesis in Transgenic Zebrafish.", "journal": "Int. J. Mol. Sci.", "date": "2023", "authors": "Fung Connie, Wilding Brendan, Schittenhelm Ralf B, Bryson-Richardson Robert J, Bird Phillip I", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IAF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAF6" } ], "reference": [ { "type": "PubMed", "id": "36768797", "url": "https://glygen.org/publication/PubMed/36768797" } ] } ], "pathway": [ { "id": "dre:793897", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?dre:793897", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K9R9-1", "protein_name": "Proteasome activator complex subunit 4", "gene_name": "Psme4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEAPERAGGGEPPEPGGRPVLGPRAFVPQKEIVYNKLLPYAERLDAESDLQLAQIKSNLGRAVQLQELWPGGLFWTRKLSTYIRLYGRKFSKEDHVLFIKLLYELVSIPKLEISMMQGFARLLINLLKKKELLSRDDLELPWRPLYDMVERILYSKTEHLRLNSFPNSIENVLKTLVKSCRPYFPADATAEMLEEWRPLMCPFDVTMQKAVSYFEIFLPTSLPPELHHKGFKLWFDELIGLWVSVQNLPQWEGQLVNLFARLATDNIGYIDWDPYVPKIFTRILRSLNLPVGSSQVLVPRFLTNAYDIGHAVIWITAMMGGPSKLVQKHLAGLFNSITSFYHPSNNGRWLNKLMKLLQRLPNSVVRRLHRERFKKPSWLTPVPESHKLTDEDVTDFVQCIIQPVLLAMFSKTGSLEAAQALQNLALMRPELVIPPVLERTYPALETLTEPHQLTATLNCVIGVARSLVSGSKWFPEGPTHMLPLLMRALPGVDPNDFSKCMITFQFIGTFSTLVPLVDCSSVLQERNDLTEIEKELCSATAEFEDFVLQFMDRCFGLIESSTLEQTREETETEKMTHLESLVELGLSSTFSTILTQCSKDIFMVALQKVFNFSVSHIFETRVAGRMVADMCRAAVKCCPEESLKLFVPHCYGVITQLTMNDDVLNEEELDKELLWNLQLLSEITRVDGKKLLLYREQLVKILQRTLHLTCKQGYTLSCNLLHHLLRSTTLIYPTEYCSVPGGFNKPPSEYFPIKDWGKPGDLWNLGIQWHVPSSEEVSFAFYLLQSFLQPELIKLQRCGDGELEMSRDDILQSLTIVHNCLIGSGNLLPPLKGEPVTNLVPSMVSLEETKLYTGLEHDLSKENHREVIASVIRKLLSHILDNSEDDTKSLFLIIKIIGDLLQFQGSHKHEFDSRWKSFNLVKKSMENRLHGKKQHIRALLIDRVMLQHELRTLTVEGCEYKKIHQDMIRDLLRLSTSSYSQVRNKAQQTFFAALGAYNFCCRDIIPLVLEFLRPDRKDVTQQQFKGALYCLLGNHSGVCLANLHDWDCIVQTWPALVSSGLSQAMSLEKPSIVRLFDDLAEKIHRQYETIGLDFTIPKSCAAIAELLQQSKNPSISQTLLSPEKIKEGQKRQQDKNADAVRNYECLVNTLLDGVEQRNLPWKFEHIGIGLLSLLLRDDRVLPLRAIRFFVENLNHDAIVVRKMAISAVAGILKQLKRTHKKLTINPYEISGCPKPATVLAGDRPDNHWLHYDSKNIPRTKKEWESSCFVEKTHWGYYNWPKNMVVYAGVEEQPKLGRSREDMTEAEQIIYDRFSDPKFVEQLITFLSLEDRKGRDKFSPRRFCLFKGIFRNFDDAFLPVLKPHLERLVADSHESTQRCVAEIIAGLIRGSKHWTFEKVEKLWELLCPLLRTALSNMTVETYNDWGTCIATSCESRDPRKLHWLFELLLESPLSGEGGSFVDACRLYVLQGGLAQQEWRVPELLHRLLKYLEPKLTQVYKNVRERIGSVLTYIFMIDVSLPNTAPTTSPCIPEFTARVLEKLKPLTDVDEEIQNHVMEENGIGEEDERTQGIKLLKTILKWLMASAGRSFSTAVKEQLQLLPLFFKIAPVENDNSYDELKRDAKLCLSLMSQGLLYPQQVPLILQVLSQTARSSSWHARYTVLTYLQTMVFYNLFIFLNNEDAVKDIRWLIIRLLEDEQLEVREMAATTLSGLLQCNFLTMDSAMQSHFEQLCKTKLPKKRKRDPGSVGDTIPSAELVKRHAGVLGLGACVLSSPYDVPTWMPQLLMNLSAHLNDPQPIEMTVKKTLSNFRRTHHDNWQEHKQQFTDDQLLVLTDLLVSPCYYA", "length": 1843 }, "evidence": [ { "id": "HGNC:20635", "url": "https://alliancegenome.org/gene/HGNC:20635#orthology", "database": "AGR" }, { "id": "SGD:S000001887", "url": "https://alliancegenome.org/gene/SGD:S000001887#orthology", "database": "AGR" }, { "id": "RGD:1591971", "url": "https://alliancegenome.org/gene/RGD:1591971#orthology", "database": "AGR" }, { "id": "MGI:2143994", "url": "https://alliancegenome.org/gene/MGI:2143994#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-091204-452", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-091204-452#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A2R9YJG8-1", "protein_name": "Proteasome activator complex subunit 4B", "gene_name": "psme4b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MKKEQAEILGFVPQKEIVYNKLLPYADQLDRESNDILAQIKGNLGRAVQLRELWPGVLFWTRKLSTYLRLYGRKFSKEDHVLFIKLLYELVTIPKLEISMMQSFARLLVNLLKKKELLSRDDLELPWRPLYDLYESILYSKTEHLGLNWFPNYRAEASTKQKMLNIVRKRSVENVLKTLVKSCRVYFPESATQEMLDEWRPLLCPFDVTMQKAIGYFELFLPTIMPPEQHDKGFKLWFDEMMNLWVSVQNLPAWEGNLVNLFARLANDNIGYVNWDPYIPKIFTRILRSFNLPVGTSQMVVPRYLTNSYDIGHVVLWISSMLGGPQNQSQKQLNGLFSSIASFYHPSNNGRWLMKLMKLLQRLPASIVRRLHRERYKKPCWITPVPSTHKLTDQDVTDFVESMKQPVLMAMFSKTGSMDAAQALQNLALMRPELVIPPVLEKTYPAMETLTEPHQLTATLSCMIGMARSLLSGGRHYPEGPAHVLPLLMRALPGVDPNDFSKCMITFQFIATFTTLVPLVDCSSALHDKNDLTEMERELCSASAEFEDFVLQFMDRCFALIDSSTLEQTREETETEKMTHLESLVELGLSSTFSTILTQCSMEIFKVALEKVFNFATTNIFETRVAGRMVADMCRAASKCHPAESLRLFVPHCCNAITHLTANEDVSNEEELDKELLWNLQLLSEVTRVDGEKLLPYRTQLVQILQLTLRLRCKQGYSLACNLLHHVLRSTALIYPTDYCSVPGGFSRPLQEYLPIKDWGRPGDLWNLEIQWHVPSTEETAFVFYVLDLLLQPELQRLQRYAQGEQEMSRDDVLQSLCIVQHCLLGAGSMLPPLDGSTVTGLVPSMVNLEETKLYIGVDYDQSRENYREAVCKVMRQLLHYILEHSEDDTKSLFAIIKIISDLMHFKGSHKHEFDSRWKSFTLVKKSMENRLHGKKQHIRALLIDRVLLQHEMRKLLVEGCEYKTVHQDLLRDLLRLSTSTYSQVRSKAQNVLFTALGTYNFCCRDITPRVLEFLEPTRTDVTQQQFKGALYCLLGNHCGVCLANLHDWDCIAQTWPAIVRSGLSSAMSLEKPSIVRLFDDLADKVHRQYETIGIDFTVPENAVFLGRSITNSSQPTPHMGTPEDQELQQGLAVQQAKNREAEQKYEKLVKDLLECLDDRDLPWKFEHIAIGFLSLLLRDDYPLPAPAVFFFVQSLNHDALVVRKMAIAAVAGILKQLKRPRKKIPVNPCDISGVTEPEELEAGDRPGNDWLQYHSESLPNSQQDWDAFCFVEKTHWGYYSWPKKLMVYAPAAEQPKDLAPDTMSEREAIINDHFTDPTFINQLIKFLSLEDRKGKDKFNPRRFCLFKGLFRNYSDAFLPVLKPHMERLANDSHESTQRCVAEIIAGLIRGSKHWSFGKVEALWAFLIPLMRTALSNITVETYADWGTCVATACESRDPRKLHWLLEMLMECPLSGEGGSFVDACHLYVLQGGLAQQEWRVPELLHRLLSYLEPKLTQVYKNVRERIGSVLTYIFMIDVALPYTLPTKSPHIAEFTERILSQLKPLIEGDEEIQNHVVEENGVGEQDERTQAIKLLKTVLKWLMASAGRSFSTPVPQQLQLLPLLFKIAPVENDDSYDELKRDAKTCLSLMSQGLLYPEQIPMVLAVLHEIAGSSSWHARYSVLTYLQTMVFYNLFTILSSEQCVQGVRALVIRLLEDEQLEVREMAATTLSGFLQCNFLAMDSSMQTHFEALCKTRLPKKRKRDVGSVMDTIPSVDLVRRHAGVLGLSACILSSPYDVPTWMPQLLMDLSAHLNDTQPIEMTVKKTLSNFRRTHHDNWLEHKQQFTDDQLVVLTDLLVSPCYYA", "length": 1845 }, "evidence": [ { "id": "HGNC:20635", "url": "https://alliancegenome.org/gene/HGNC:20635#orthology", "database": "AGR" }, { "id": "SGD:S000001887", "url": "https://alliancegenome.org/gene/SGD:S000001887#orthology", "database": "AGR" }, { "id": "RGD:1591971", "url": "https://alliancegenome.org/gene/RGD:1591971#orthology", "database": "AGR" }, { "id": "MGI:2143994", "url": "https://alliancegenome.org/gene/MGI:2143994#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "P43583-1", "protein_name": "Proteasome activator BLM10", "gene_name": "BLM10", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MTANNDDDIKSPIPITNKTLSQLKRFERSPGRPSSSQGEIKRKKSRLYAADGRPHSPLRARSATPTLQDQKLFNGMDSTSLLNERLQHYTLDYVSDRAQHMKNIYDPSSRWFSRSVRPEFPIEEFLPYKTESHEDQAKYLCHVLVNLYIAISSLDIQGLISISSKDLADLKKEVDDLALKTDLFRLSNNTAENDLLGNDIADYDDAEGLEDELDEYFDLAGPDFNATGKITAKSATIVNVNHWTNELKNCLHFDFPVALRKSLATVYYYLSLVQGQKVYRQMHVDMFERLVSLDDDRTNFTELLQKQGLLLDHQIMLNFLCEFLPYPDPDYARYELSSKEDLQLFRLLLKHAHNAKPFFDKSKESLLVDTMNFLLSSLAPSTMMAVMPIVTSVVPYHYHIHSKIIDYFPFCYSIWSSVSANVAIDTHMYDFVGSISKDVHNKILSSEHEKDVVGVEFGEFGIFTDDQMTFMFNRLQGHLRTDGQIHSYSRTVKPFVYAINGSKKDRFFEKLVSLAKAIETFIHPSNNGFWTKPNAKFVHAFIKSYHGRVKYEEDICARGVTNGICLTSFCHEEIVEIFLNIISLGSQNKNPDIANYYISCFAYLLELDPSNAYLIYDKILIDLYDTLADQFINSRHRIISSLKQFTRVIRFIVMDKLYRVHITNVLSMLVSKLDMNDTNLTSNLINGIVSIAAFIPIQDLTGEDDYISFESDTLPLVQQHFYHIKCGESSKTFRVDDELLNNAFKASTTVFQSMLKVYVEKIFQLVDVDLEDSLVTKINQTTMILQESMDDKIFNYFASLLQRNFWSNDSFKEKDPNYELVTIPLAALVRRNNGLSKELVRTLLFHIKEQIKRGAGSVRSTSEIQQRDVKLVLYLTALNDVLRQCHESLLEYSDELITFMKYLYDNVTNPPLDVITSIVIHSALATLCTTEITDCRLFPEDSKIPEKDRWGGLQFDPRRFDKQHLSFQWHVPSSDEITLSISILESLSEYCINNVEELMKAPRHDSEYGDMIQKYVLVMTHTLSGSSLLFDPDFNKYRTQSNLSYREKLILLKNIRENNCDPQELDIDIEQIRSGKDDEDYIESKDIEAGLNAGVSDVVQLRDEFPDELIVDEEVVSEMPSGVNTPIAGTHGTDNSAMSSDLAFRDLDIYTCNYYFGNTTEEKLQNPQYLQVHRVRARIGHFFHKLYVFLSTNFENNTNMFQILLHGLKVWFTDLGQETVFNEDPNAFIDVDFLENVQSLSHVNEPFTRTNFAIRANSLHQSRVLLHSTNRKASKLENLLLVDIIQLATSLYPDIYKPAQGTLVHCMKQLVGSYGVVINKIIPSLEKAIKDHDYMKIQVILNVLLIKKIHRKLMTDYKDIGRLIFLLIECCRVNELEIGMYADKILTDIVIGIKIPSSVCVISDQAFLPLAPPDGTINLQVEAVKLAKKKKREYYLSLLVDLQDKLLDKLDNEKDMGWKIRMFILRFVTQIQSNLESKPDKRAVFSIISQISTKHPEIIHLVVKSLLSTCNKIISLSDYEYDITRAYKNEFNPSFVEILDTSTTSFPKTFTEEMNNFDNPKYFIDLRAYVGWLCWGRLMYVMSPKALKLNLRENELEVLKTAGHLLTREFLRDVTMNLVQDNETRGVFSSGNVSFFSLVILLISSGFCELNMSDLFELCESYYNKDDKASMIMSVEIVAGLVCGSKFMSVSDLDKRDTFIENFLAKCLDYELNHDAFEIWSTLAWWLPAVVDLRRSKTFFCHFINADGMFDRESDAATHQTSKIYMLRSILMSMEFRAPDVGKLFDELVFDHPYDQVRQAVAKLLTTLVQNQSNPSISDPTTLLEAERNDPDGLGLPLKSVPEKVDAYIKKQFEIIKNLEDSVVGLNPQQFIKTDYFYRTSTIFYWIKEMARGPNKVLLVPYLVDYVLPFLIGLVKHKDVCALASLDPVRLYAGLGYMPIRKNHVAAIVDYVCSSNVALSSNQTKLQLAFIQHFLSAELLQLTEEEKNKILEFVVSNLYNEQFVEVRVRAASILSDIVHNWKEEQPLLSLIERFAKGLDVNKYTSKERQKLSKTDIKIHGNVLGLGAIISAFPYVFPLPPWIPKQLSNLSSWARTSGMTGQAAKNTISEFKKVRADTWKFDRASFNTEELEDLEGVLWRSYYA", "length": 2143 }, "evidence": [ { "id": "HGNC:20635", "url": "https://alliancegenome.org/gene/HGNC:20635#orthology", "database": "AGR" }, { "id": "SGD:S000001887", "url": "https://alliancegenome.org/gene/SGD:S000001887#orthology", "database": "AGR" }, { "id": "RGD:1591971", "url": "https://alliancegenome.org/gene/RGD:1591971#orthology", "database": "AGR" }, { "id": "MGI:2143994", "url": "https://alliancegenome.org/gene/MGI:2143994#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-091204-452", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-091204-452#orthology", "database": "AGR" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q14997-1", "protein_name": "Proteasome activator complex subunit 4", "gene_name": "PSME4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEPAERAGVGEPPEPGGRPEPGPRGFVPQKEIVYNKLLPYAERLDAESDLQLAQIKCNLGRAVQLQELWPGGLFWTRKLSTYIRLYGRKFSKEDHVLFIKLLYELVSIPKLEISMMQGFARLLINLLKKKELLSRADLELPWRPLYDMVERILYSKTEHLGLNWFPNSVENILKTLVKSCRPYFPADATAEMLEEWRPLMCPFDVTMQKAITYFEIFLPTSLPPELHHKGFKLWFDELIGLWVSVQNLPQWEGQLVNLFARLATDNIGYIDWDPYVPKIFTRILRSLNLPVGSSQVLVPRFLTNAYDIGHAVIWITAMMGGPSKLVQKHLAGLFNSITSFYHPSNNGRWLNKLMKLLQRLPNSVVRRLHRERYKKPSWLTPVPDSHKLTDQDVTDFVQCIIQPVLLAMFSKTGSLEAAQALQNLALMRPELVIPPVLERTYPALETLTEPHQLTATLSCVIGVARSLVSGGRWFPEGPTHMLPLLMRALPGVDPNDFSKCMITFQFIATFSTLVPLVDCSSVLQERNDLTEVERELCSATAEFEDFVLQFMDRCFGLIESSTLEQTREETETEKMTHLESLVELGLSSTFSTILTQCSKEIFMVALQKVFNFSTSHIFETRVAGRMVADMCRAAVKCCPEESLKLFVPHCCSVITQLTMNDDVLNDEELDKELLWNLQLLSEITRVDGRKLLLYREQLVKILQRTLHLTCKQGYTLSCNLLHHLLRSTTLIYPTEYCSVPGGFDKPPSEYFPIKDWGKPGDLWNLGIQWHVPSSEEVSFAFYLLDSFLQPELVKLQHCGDGKLEMSRDDILQSLTIVHNCLIGSGNLLPPLKGEPVTNLVPSMVSLEETKLYTGLEYDLSRENHREVIATVIRKLLNHILDNSEDDTKSLFLIIKIIGDLLQFQGSHKHEFDSRWKSFNLVKKSMENRLHGKKQHIRALLIDRVMLQHELRTLTVEGCEYKKIHQDMIRDLLRLSTSSYSQVRNKAQQTFFAALGAYNFCCRDIIPLVLEFLRPDRQGVTQQQFKGALYCLLGNHSGVCLANLHDWDCIVQTWPAIVSSGLSQAMSLEKPSIVRLFDDLAEKIHRQYETIGLDFTIPKSCVEIAELLQQSKNPSINQILLSPEKIKEGIKRQQEKNADALRNYENLVDTLLDGVEQRNLPWKFEHIGIGLLSLLLRDDRVLPLRAIRFFVENLNHDAIVVRKMAISAVAGILKQLKRTHKKLTINPCEISGCPKPTQIIAGDRPDNHWLHYDSKTIPRTKKEWESSCFVEKTHWGYYTWPKNMVVYAGVEEQPKLGRSREDMTEAEQIIFDHFSDPKFVEQLITFLSLEDRKGKDKFNPRRFCLFKGIFRNFDDAFLPVLKPHLEHLVADSHESTQRCVAEIIAGLIRGSKHWTFEKVEKLWELLCPLLRTALSNITVETYNDWGACIATSCESRDPRKLHWLFELLLESPLSGEGGSFVDACRLYVLQGGLAQQEWRVPELLHRLLKYLEPKLTQVYKNVRERIGSVLTYIFMIDVSLPNTTPTISPHVPEFTARILEKLKPLMDVDEEIQNHVMEENGIGEEDERTQGIKLLKTILKWLMASAGRSFSTAVTEQLQLLPLFFKIAPVENDNSYDELKRDAKLCLSLMSQGLLYPHQVPLVLQVLKQTARSSSWHARYTVLTYLQTMVFYNLFIFLNNEDAVKDIRWLVISLLEDEQLEVREMAATTLSGLLQCNFLTMDSPMQIHFEQLCKTKLPKKRKRDPGSVGDTIPSAELVKRHAGVLGLGACVLSSPYDVPTWMPQLLMNLSAHLNDPQPIEMTVKKTLSNFRRTHHDNWQEHKQQFTDDQLLVLTDLLVSPCYYA", 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"MEAPERAGGGEPPEPGGRPVLGPRAFVPQKEIVYNKLLPYAERLDAESDLQLAQIKSNLGRAVQLQELWPGGLFWTRKLSTYIRLYGRKFSKEDHVLFIKLLYELVSIPKLEISMMQGFARLLINLLKKKELLSRDDLELPWRPLYDLVERILYSKTEHLRLNSFPNSIENVLKTLVKSCRPYFPADSTAEMLEEWRPLMCPFDVTMQKAISYFEIFLPTSLPPELHHKGFKLWFDELIGLWVSVQNLPQWEGQLVNLFARLATDNIGYIDWDPYVPKIFTRILRSLNLPVGSSQVLVPRFLTNAYDIGHAVIWITAMMGGPSKLVQKHLAGLFNSITSFYHPSNNGRWLNKLMKLLQRLPNSVVRRLHRERFKKPSWLTPVPESHKLTDEDVTDFVQCIIQPVLLAMFSKTGSLEAAQALQNLALMRPELVIPPVLERTYPALETLTEPHQLTATLNCVIGVARSLVSGSKWFPEGPTHMLPLLMRALPGVDPNDFSKCMITFQFIGTFSTLVPLVDCSSVLQERNDLTEIEKELCSATAEFEDFVLQFMDRCFGLIESSTLEQTREETETEKMTHLESLVELGLSSTFSTILTQCSKDIFMVALQKVFNFSVSHIFETRVAGRMVADMCRAAVKCCPEESLKLFVPHCYGVITQLTMNDDVLNEEELDKELLWNLQLLSEITRVDGKKLLLYREQLVKILQRTLHLTCKQGYTLSCNLLHHLLRSTTLIYPTEYCSVPGGFNKPPSEYFPVKDWGKPGDLWNLGIQWHVPSSEEVSFAFYLLDSFLQPELIKLQCCGDGELEMSRDDILQSLTIVHSCLIGSGNLLPPLKGEAVTNLVPSMVSLEETKLYTGLEHDLSRENYREVIASVIRKLLSHILDNSEDDTKSLFLIIKIIGDLLHFQGSHKHEFDSRWKSFNLVKKSMENRLHGKKQHIRALLIDRVMLQHELRTLTVEGCEYKKIHQDMIRDLLRLSTSSYSQVRNKAQQTFFAALGAYNFCCRDIIPLVLEFLRPDRKDVTQQQFKGALYCLLGNHSGVCLANLHDWDCIVQTWPALVSSGLSQAMSLEKPSIVRLFDDLAEKIHRQYETIGLDFTIPKSCAAIAELLQQSKNPSISQTLLSPEKIKEGQKRQQDKNADALRNYECLVNTLLDGVEQRNLPWKFEHIGIGLLSLLLRDDRVLPLRAIRFFVENLNHDAIVVRKMAISAVAGILKQLKRTHKKLTINPYEISGCPKPTKILAGDRPDNHWLHYDSKNIPRTKKEWESSCFVEKTHWGYYNWPKNMVVYAGVEEQPKLGRSREDMIEAEQIIYDRFSDPKFVEQLITFLSLEDRKGRDKFSPRRFCLFKGIFRNFDDAFLPVLKPHLERLVADSHESTQRCVAEIIAGLIRGSKHWTFEKVEKLWELLCPLLRTALSNMTVETYNDWGTCIATSCESRDPRKLHWLFELLLESPLSGEGGSFVDACRLYVLQGGLAQQEWRVPELLHRLLKYLEPKLTQVYKNVRERIGSVLTYIFMIDVSLPNTAPTTSPCIPEFTARVLEKLKPLTDVDEEIQNHVMEENGIGEEDERTQGIKLLKTILKWLMASAGRSFSTAVKEQLQLLPLFFKIAPVENDNSYDELKRDAKLCLSLMSQGLLYPQQVPLILQVLSQTARSSSWHARYTVLTYLQTMVFYNLFIFLNNEDAVKDIRWLIICLLEDEQLEVREMAATTLSGLLQCNFLTMDSAMQIHFEQLCKTKLPKKRKRDPGSVGDTIPSAELVKRHAGVLGLGACVLSSPYDVPTWMPQLLMNLSAHLNDPQPIEMTVKKTLSNFRRTHHDNWQEHKQQFTDDQLLVLTDLLVSPCYYA", "length": 1843 }, "evidence": [ { "id": "HGNC:20635", "url": "https://alliancegenome.org/gene/HGNC:20635#orthology", "database": "AGR" }, { "id": "SGD:S000001887", "url": "https://alliancegenome.org/gene/SGD:S000001887#orthology", "database": "AGR" }, { "id": "RGD:1591971", "url": "https://alliancegenome.org/gene/RGD:1591971#orthology", "database": "AGR" }, { "id": "MGI:2143994", "url": "https://alliancegenome.org/gene/MGI:2143994#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-091204-452", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-091204-452#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "spermatoproteasome complex", "id": "GO:1990111", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990111", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IAF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAF6" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IAF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAF6" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IAF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAF6" } ], "pmid": "" }, { "name": "nuclear speck", "id": "GO:0016607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IAF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAF6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IAF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAF6" } ], "pmid": "" }, { "name": "proteasomal ubiquitin-independent protein catabolic process", "id": "GO:0010499", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010499", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IAF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAF6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "peptidase activator activity", "id": "GO:0016504", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016504", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IAF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAF6" } ], "pmid": "" }, { "name": "lysine-acetylated histone binding", "id": "GO:0070577", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070577", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IAF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAF6" } ], "pmid": "" }, { "name": "proteasome binding", "id": "GO:0070628", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070628", "evidence": [ { "database": "UniProtKB", "id": "A0A0R4IAF6", "url": "https://www.uniprot.org/uniprotkb/A0A0R4IAF6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1058, "end_pos": 1060, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1117, "end_pos": 1119, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1448, "end_pos": 1450, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1826, "end_pos": 1828, "annotation": "n_glycosylation_sequon" }, { "start_pos": 901, "end_pos": 903, "annotation": "n_glycosylation_sequon" }, { "start_pos": 976, "end_pos": 978, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.agr", "label": "AGR Homologs" } ], "sequence_features": { "n_linked_sites": [], 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"sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 4 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }