{ "uniprot_canonical_ac": "A0A0G2QC02-1", "uniprot_ac": "A0A0G2QC02", "uniprot_id": "A0A0G2QC02_RAT", "mass": { "chemical_mass": 137180.0, "monoisotopic_mass": 137180.0 }, "refseq": {}, "gene_names": [ { "name": "Skic2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0G2QC02", "id": "A0A0G2QC02" }, { "name": "Skiv2l", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2QC02", "id": "A0A0G2QC02" } ], "protein_names": [ { "name": "Superkiller complex protein 2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0G2QC02/entry#names_and_taxonomy", "id": "A0A0G2QC02" }, { "name": "3.6.4.13", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2QC02/entry#names_and_taxonomy", "id": "A0A0G2QC02" } ], "function": [ { "annotation": "Helicase component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways. The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation. SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling. In the nucleus, the SKI complex associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C).", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2QC02", "url": "https://www.uniprot.org/uniprotkb/A0A0G2QC02#function" }, { "database": "UniProtKB", "id": "ARBA00054618", "url": "https://www.uniprot.org/uniprotkb/ARBA00054618#function" } ] } ], "disease": [ { "disease_id": "DOID:0111416", "recommended_name": { "id": "DOID:0111416", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111416", "name": "trichohepatoenteric syndrome 2", "description": "A trichohepatoenteric syndrome that has_material_basis_in homozygous or compound heterozygous mutation in the SKIV2L gene on chromosome 6p21.33." }, "synonyms": [ { "id": "DOID:0111416", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111416", "name": "THES2", "description": "" }, { "id": "MONDO:0013818", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013818", "name": "trichohepatoenteric syndrome 2", "description": "Any tricho-hepato-enteric syndrome in which the cause of the disease is a mutation in the SKIV2L gene." }, { "id": "MONDO:0013818", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013818", "name": "SKIV2L tricho-hepato-enteric syndrome", "description": "" }, { "id": "MONDO:0013818", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013818", "name": "Trichohepatoenteric syndrome 2", "description": "" }, { "id": "MONDO:0013818", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013818", "name": "Trichohepatoenteric syndrome type 2", "description": "" }, { "id": "MONDO:0013818", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013818", "name": "tricho-hepato-enteric syndrome caused by mutation in SKIV2L", "description": "" }, { "id": "MONDO:0013818", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013818", "name": "THES2", "description": "" }, { "id": "MONDO:0013818", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013818", "name": "TRICHOHEPATOENTERIC syndrome 2", "description": "" }, { "id": "MIM:614602", "resource": "MIM", "url": "https://www.omim.org/entry/614602", "name": "Trichohepatoenteric syndrome 2", "description": "Trichohepatoenteric syndrome 2" } ], "unlinked_id_list": [], "evidence": [ { "id": "0111416", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0111416" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2QC02", "url": "https://www.uniprot.org/uniprotkb/A0A0G2QC02" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "gene": [ { "name": "Skic2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2QC02", "locus": { "chromosome": "20", "start_pos": 3993261, "end_pos": 3982593, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000000421", "url": "https://www.ensembl.org/id/ENSRNOG00000000421" } ] } } ], "crossref": [ { "id": "RGD:1303059", "url": "https://alliancegenome.org/gene/RGD:1303059", "database": "AGR", "categories": [ "Protein Classification" ] }, { "id": "A0A0G2QC02", "url": "https://alphafold.ebi.ac.uk/entry/A0A0G2QC02", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSRNOG00000000421", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000000421", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd18027", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18027", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18795", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18795", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001650", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001650", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011545", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011545", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014001", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014001", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016438", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016438", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025696", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025696", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040801", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040801", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048392", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048392", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050699", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050699", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "DHVNIIM", "url": "https://omabrowser.org/oma/group/DHVNIIM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A0G2QC02", "url": "https://www.orthodb.org/?gene=A0A0G2QC02", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12131", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12131", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12131:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12131:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00270", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00270", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00271", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00271", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF08148", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF08148", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13234", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13234", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF17911", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17911", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF21408", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF21408", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-429958", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-429958", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "1303059", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1303059", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "13065", "url": "https://www.rhea-db.org/rhea/13065", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A0G2QC02", "url": "https://www.uniprot.org/uniprotkb/A0A0G2QC02", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2QC02-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2QC02-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AVJ0", "url": "https://www.uniprot.org/uniprotkb/A0A8I6AVJ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AVJ0-1", "url": "https://www.uniprot.org/uniprotkb/A0A8I6AVJ0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "TCDLSFVVLPPPDPLNLPLRALEVGCTGRWELLNVPGPPESTLPHGLPPCAPDLCQEAEQLFLSSPAWLPLHGVEHSARKWQRKTDPWSLLAALGTPVPSDLQAQRHPTTGHILGYKEVLLENTNLSATTSLSLRRPPGPASQSLWGNPTQYPFWPGGMDEPSITDLSTREEAEEEIDFEKDLLTVPPGFKKGVDFAPKDHPAPVPGLLSLSRLLEPLDLSGGDEGEGEAAGGPRGDAASASPSSTPLIRASSLEDLVLKEASTVVSTLEPLKPPPQEQWAVPVDVTSPVGDFYRLIPQPAFQWAFEPDVFQKQAILHLEQHDSVFVAAHTSAGKTVVAEYAIALAQKHMTRTIYTSPIKALSNQKFRDFRNTFGDVGLLTGDVQLHPEASCLIMTTEILRSMLYSGSDVIRDLEWVIFDEVHYINDAERGVVWEEVLIMLPEHVSIILLSATVPNALEFADWIGRLKRRQIYVISTVARPVPLEHYLFTGNSPKTQGELFLLLDSRGAFHTKGYYAAVEAKKERMSKHAQTFGAKQPTHQGGPAQDRGVYLALLASLRTRAQLPVVVFTFSRGRCDEQASGLTSLDLTTSSEKSEIHLFLQRCLARLRGSDRQLPQVLHMSELLRRGLGVHHSGILPILKEIVEMLFSRGLVKVLFATETFAMGVNMPARTVVFDSMRKHDGSTFRDLLPGEYVQMAGRAGRRGLDPTGTVILLCKGRVPEMADLHRMMMGKPSQLQSQFRLTYTMILNLLRVDALRVEDMMKRSFSEFPSRKDSKAHEQALADLTKRLGALEEPDVTGQLADLPEYYSWAEELTETRNMIQRRIMESVNGLKSLSVGRVVVVKNEEHHNALGVILQVSSNSTSRVFTTLVLCDKPAVSENPRDKGPATPDVPHPDDLVGFKLFLPEGPCEHTVAKLQPGDVAAISTKVLRVNGEKISEDFSKRQQPKFRKDPPLAAVTTAVQELLRLAQAYPAGPPTLDPINDLQLKDVAVVEGGLRARKLEELIRGAQCVHSPRFPAQYVKLQERMQIQKEMERLRFLLSDQSLLLLPEYHQRVEVLRTLGYVDEAGTVKLAGRVACAMSSHELLLTELMFDNALSALRPEEIAALLSGLVCQSPGDPGDQLPSTLKQGVERVKAVAKRIGEVQVACGLNQTVEEFVGELNFGLVEVVYEWARGMPFSELAGLSGTPEGLVVRCIQRLAEMCRSLRGAARLVGEPVLGAKMETAATLLRRDIVFAASLYTQ", "length": 1244, "header": "tr|A0A0G2QC02-1|A0A0G2QC02_RAT Isoform 1 of Superkiller complex protein 2 OS=Rattus norvegicus OX=10116 GN=Skic2 PE=1 SV=2 CANONICAL=A0A0G2QC02-1" }, "isoforms": [ { "isoform_ac": "A0A0G2QC02-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2QC02/entry#A0A0G2QC02-1", "sequence": { "sequence": "TCDLSFVVLPPPDPLNLPLRALEVGCTGRWELLNVPGPPESTLPHGLPPCAPDLCQEAEQLFLSSPAWLPLHGVEHSARKWQRKTDPWSLLAALGTPVPSDLQAQRHPTTGHILGYKEVLLENTNLSATTSLSLRRPPGPASQSLWGNPTQYPFWPGGMDEPSITDLSTREEAEEEIDFEKDLLTVPPGFKKGVDFAPKDHPAPVPGLLSLSRLLEPLDLSGGDEGEGEAAGGPRGDAASASPSSTPLIRASSLEDLVLKEASTVVSTLEPLKPPPQEQWAVPVDVTSPVGDFYRLIPQPAFQWAFEPDVFQKQAILHLEQHDSVFVAAHTSAGKTVVAEYAIALAQKHMTRTIYTSPIKALSNQKFRDFRNTFGDVGLLTGDVQLHPEASCLIMTTEILRSMLYSGSDVIRDLEWVIFDEVHYINDAERGVVWEEVLIMLPEHVSIILLSATVPNALEFADWIGRLKRRQIYVISTVARPVPLEHYLFTGNSPKTQGELFLLLDSRGAFHTKGYYAAVEAKKERMSKHAQTFGAKQPTHQGGPAQDRGVYLALLASLRTRAQLPVVVFTFSRGRCDEQASGLTSLDLTTSSEKSEIHLFLQRCLARLRGSDRQLPQVLHMSELLRRGLGVHHSGILPILKEIVEMLFSRGLVKVLFATETFAMGVNMPARTVVFDSMRKHDGSTFRDLLPGEYVQMAGRAGRRGLDPTGTVILLCKGRVPEMADLHRMMMGKPSQLQSQFRLTYTMILNLLRVDALRVEDMMKRSFSEFPSRKDSKAHEQALADLTKRLGALEEPDVTGQLADLPEYYSWAEELTETRNMIQRRIMESVNGLKSLSVGRVVVVKNEEHHNALGVILQVSSNSTSRVFTTLVLCDKPAVSENPRDKGPATPDVPHPDDLVGFKLFLPEGPCEHTVAKLQPGDVAAISTKVLRVNGEKISEDFSKRQQPKFRKDPPLAAVTTAVQELLRLAQAYPAGPPTLDPINDLQLKDVAVVEGGLRARKLEELIRGAQCVHSPRFPAQYVKLQERMQIQKEMERLRFLLSDQSLLLLPEYHQRVEVLRTLGYVDEAGTVKLAGRVACAMSSHELLLTELMFDNALSALRPEEIAALLSGLVCQSPGDPGDQLPSTLKQGVERVKAVAKRIGEVQVACGLNQTVEEFVGELNFGLVEVVYEWARGMPFSELAGLSGTPEGLVVRCIQRLAEMCRSLRGAARLVGEPVLGAKMETAATLLRRDIVFAASLYTQ", "length": 1244, "header": "tr|A0A0G2QC02-1|A0A0G2QC02_RAT Isoform 1 of Superkiller complex protein 2 OS=Rattus norvegicus OX=10116 GN=Skic2 PE=1 SV=2 CANONICAL=A0A0G2QC02-1" }, "locus": { "chromosome": "20", "start_pos": 3993102, "end_pos": 3982711, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000000481.5", "url": "https://www.ensembl.org/id/ENSRNOT00000000481.5" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000000481.5", "url": "https://www.ensembl.org/id/ENSRNOP00000000481.5" } ] } }, { "isoform_ac": "A0A8I6AVJ0-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2QC02/entry#A0A8I6AVJ0-1", "sequence": { "sequence": "MMETERLVLPPPDPLNLPLRALEVGCTGRWELLNVPGPPESTLPHGLPPCAPDLCQEAEQLFLSSPAWLPLHGVEHSARKWQRKTDPWSLLAALGTPVPSDLQAQRHPTTGHILGYKEVLLENTNLSATTSLSLRRPPGPASQSLWGNPTQYPFWPGGMDEPSITDLSTREEAEEEIDFEKDLLTVPPGFKKGVDFAPKDHPAPVPGLLSLSRLLEPLDLSGGDEGEGEAAGGPRGDAASASPSSTPLIRASSLEDLVLKEASTVVSTLEPLKPPPQEQWAVPVDVTSPVGDFYRLIPQPAFQWAFEPDVFQKQAILHLEQHDSVFVAAHTSAGKTVVAEYAIALAQKHMTRTIYTSPIKALSNQKFRDFRNTFGDVGLLTGDVQLHPEASCLIMTTEILRSMLYSGSDVIRDLEWVIFDEVHYINDAERGVVWEEVLIMLPEHVSIILLSATVPNALEFADWIGRLKRRQIYVISTVARPVPLEHYLFTGNSPKTQGELFLLLDSRGAFHTKGYYAAVEAKKERMSKHAQTFGAKQPTHQGGPAQDRGVYLALLASLRTRAQLPVVVFTFSRGRCDEQASGLTSLDLTTSSEKSEIHLFLQRCLARLRGSDRQLPQVLHMSELLRRGLGVHHSGILPILKEIVEMLFSRGLVKVLFATETFAMGVNMPARTVVFDSMRKHDGSTFRDLLPGEYVQMAGRAGRRGLDPTGTVILLCKGRVPEMADLHRMMMGKPSQLQSQFRLTYTMILNLLRVDALRVEDMMKRSFSEFPSRKDSKAHEQALADLTKRLGALEEPDVTGQLADLPEYYSWAEELTETRNMIQRRIMESVNGLKSLSVGRVVVVKNEEHHNALGVILQVSSNSTSRVFTTLVLCDKPAVSENPRDKGPATPDVPHPDDLVGFKLFLPEGPCEHTVAKLQPGDVAAISTKVLRVNGEKISEDFSKRQQPKFRKDPPLAAVTTAVQELLRLAQAYPAGPPTLDPINDLQLKDVAVVEGGLRARKLEELIRGAQCVHSPRFPAQYVKLQERMQIQKEMERLRFLLSDQSLLLLPEYHQRVEVLRTLGYVDEAGTVKLAGRVACAMSSHELLLTELMFDNALSALRPEEIAALLSGLVCQSPGDPGDQLPSTLKQGVERVKAVAKRIGEVQVACGLNQTVEEFVGELNFGLVEVVYEWARGMVSAWVGRGLAGRSPGPGTFVFTVLPTALLRVGRALGDPRRLGCPLYPAPG", "length": 1228, "header": "tr|A0A8I6AVJ0-1|A0A0G2QC02_RAT Computationally mapped isoform of Superkiller complex protein 2 OS=Rattus norvegicus OX=10116 GN=Skic2 PE=1 SV=1 CANONICAL=A0A0G2QC02-1" }, "locus": { "chromosome": "20", "start_pos": 3992975, "end_pos": 3982629, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000102575.1", "url": "https://www.ensembl.org/id/ENSRNOT00000102575.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000092323.1", "url": "https://www.ensembl.org/id/ENSRNOP00000092323.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nat. Commun.", "date": "2012", "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2QC02", "url": "https://www.uniprot.org/uniprotkb/A0A0G2QC02" } ], "reference": [ { "type": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" } ] } ], "pathway": [ { "id": "R-RNO-429958", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-429958", "resource": "Reactome", "description": "mRNA decay by 3' to 5' exoribonuclease" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0ZZI7-1", "protein_name": "SKI2 subunit of superkiller complex", "gene_name": "SKIV2L", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MELERIVLPPPGPLHLPLALLELGCAGRCELLPGPAPPRSTLPQGLPPFTPPLTAELEQCFLGTPAWLPPHQHERAQRCWTRVPTPRALFVLEPTPVHSSVRALRDPGTGALQGFVEELHEDSGLASSPDVSSIPQWEGGLEEPPLELLHTQGPNEEDLDLENDLLTTPPGLKRGVEFQPRAPGARGGAPSLCSVLGALDSLELGGAEEEQKKEGEGAGGGTPSQPPPDKGGAPSPTPPLRRADSLEELVMGEVLVPPTTATPSVPPQSEEEEWAVEEDCSVPVEDFEEKIPDPAFKWPFRPDAFQQRAALCLERGQSLLVAAHTSAGKTAVAEYAIALARRHMTRAIYTSPIKALSNQKFRDFRATFGDVGLLTGDVQLRTDASCLIMTTEILRSMLYNGSEVLRELEWVIFDEVHYINDAERGVVWEETLILLPEHVGLVLLSATIPNALEFAQWVGRTKRRCLRVLSTRQRPVPLEHFLYTGGGGPPSPRDLFLLLDARGGFNTQGYYAAVEAQKQRASKHTQSFGAKQPHGGGSGPGQDRAMWHSLVALLQAQGQLPAVAFTFSRGRCDAHAAALGRTDLSSAAEKGRVRGFVRRCLARLRGGDRRLPQVLQMSELLERGIGVHHSGVLPLLKEVVEMLFSQGLVKLLFATETFAMGVNMPARTVIFDSIRKHDGNNFRDLLPGEYVQMSGRAGRRGLDRTGTVIILCRGTVPDMADLHRVMLGRPSGLQSQFRLTYGTILSLQRAAALTVEGLMRNSFGEFPLRRRAAAQQRRVAELQQELKALGEPPQEGTLDDLPQYYEAVQGLLEARAELQRRVAQSVAGLKALAPGRVVVVCTPQHHNALGLILQVTAESGGGRTITTMVLSEKPTEEGGPPPSPPPDAPYPEDILLSRLFLPEGPPGAALEQLHPEDLGGIVGRTLRANPPRLLEELRRRQTARGRKDPPSPELLSALQELLRMAGGAPGGLPLLDPVGALQLRDPPAVEAAARARSLGAALGGFRCVHGPRFPQLYSQFAARRRLQAQVEQLQYELSDRSLLLLPEYRQRLGVLRALGYVADGGAVQLPGRVAALLSCHELLLTELLLGNVLSPLRPEEVAALLSCTVHPGRGEPPPKLPPNLQRGMEQIRAVAERVGRLQEEWGLPQSAEDYVGQFGFGLAEVVYEWARGMPFAALAALAPLQEGAVVRCIQRLEELCRELRRAARMLGDPGLAATMEAASGCIKRDIVFAASLYIQ", "length": 1239 }, "evidence": [ { "id": "A0A0G2QC02", "url": "https://omabrowser.org/oma/group/A0A0G2QC02/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "F1R881-1", "protein_name": "Superkiller complex protein 2 isoform X1", "gene_name": "skic2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDKIDLPPVGPDDLPLSLLEMGCSGRFELITHTLPKNKPLPPHSTLPHGLPPTCLDLKTEVEKRFLRDPAWLPVHDVDDAFNKFLKISKREKEVDSLLHCSLSQLHSGLSVVRDPTTGMLLDFTEVLLEDTGLSAKNSLSLQRQPGPPSESLRGSNTNYPFLPAGMEELTLEQIKNKSELEEDIDFEKDLMTVPPGLKAGMDFSDKEARNTKSEVNLLSLLSTFDDVLDAPPEDKEGVSQKEEIVKLPRTNSLEDLGIKDSGSSQPQGNTGSLTEQKKKNLEEEKGDNKKWAIPVDISSPCADFYKRIPDPAFKYPFELDVFQKQAILRLEAHDSVFVAAHTSAGKTVVAEYAIALSQKHMTRTIYTSPIKALSNQKFRDFKNTFGDVGLLTGDVQLNPEGSCLIMTTEILRSMLYNGSEVIRDLEWVIFDEVHYINDAERGVVWEEVLIMLPEHVSIILLSATVPNAVEFSEWIGRIKKRHIYVISTIKRPVPLEHYLYTGNSTKTQKELFMLLDATGNFLTKGYYAAVEAKKERTSKHAQSFGTKNVSQHNTTASQDRAVWQTLLNYLSQRQQTPVVAFTFSRTRCDENARSLTSLDLTTSIEKSEIHSFLQKSLTRLRGGDRQLPQILLMRDLLKRGIGVHHSGILPILKEVIEMLFSRGLVKVLFATETFAMGVNMPARTVVFDSIRKHDGTGFRNLLPGEYIQMAGRAGRRGLDATGTVIILCKAGVHDMGELHSMMLGKPTVLHSQFRLTYTMILNLLRVEALRVTDMMKRSFSENHRDTQAHEKRISELRNTLSSLPPLDTEGQLSDLLSYYHTITELHITTQSLQQAVLESVNGLKALSVGRVVIVNNSQHHNSLGVILQVSSDAVNRTFTALIICEKGNEEAASDEQSNKVALPIYSKTLFIPEGPCSHTVQKLKLQDISAITTKALKVIPERIIDNYNKRLQPRFRLDPPGQAISTATQELLRLAEANMGGMTVLDPVNDLHLKGVDVVEGVMRQRVLQDSLKDFHCIHSPTFSEQFTRVQERMSVQEELDKLLFLVSDQSLTLLPEYHQRIKVLEALQYVDSSGAVQLKGRVACQISSHELLLTELLFENTLSPLAPEESAALLSCLVFTQNTQIEPHITNTLQEGINQVLAVAQRIGDLQRDCGIAQTAEDFVAQFKFGLTEVVYCWARGMPFAEIAQLTDVQEGTIVRCIQRLDEVLKEVRQAARIVGDSVLGSKMERASLAIRRDIVFTASLYTH", "length": 1249 }, "evidence": [ { "id": "MGI:1099835", "url": "https://alliancegenome.org/gene/MGI:1099835#orthology", "database": "AGR" }, { "id": "HGNC:10898", "url": "https://alliancegenome.org/gene/HGNC:10898#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "P35207-1", "protein_name": "Antiviral helicase SKI2", "gene_name": "SKI2", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSEGFSSSSIQELYQSLKEITNNADVELFEDRITKLDFESTDEPKHANDIIKDRFLRPSNALPWSLLDMVQDVPHTSSPEDCSGKLDYKELLKVPDPINRTSYQFKRTGLEGKISGYKEEVDLKEVANANASNSLSITRSINHNQNSVRGSTAQLPFTPGGIPMKSVKTDSEQNGSSTMANATKLLHKDGQGLFDIPEGMNRGIKPMDSPAENEDQNGQFKELKQLNEIDNELDIRIEANEAKLKEEEKSAKSISEEIMEEATEETTADNADDAEIDELLPIGIDFGRTKPVSKSVPVKKEWAHVVDLNHKIENFDELIPNPARSWPFELDTFQKEAVYHLEQGDSVFVAAHTSAGKTVVAEYAIAMAHRNMTKTIYTSPIKALSNQKFRDFKETFDDVNIGLITGDVQINPDANCLIMTTEILRSMLYRGADLIRDVEFVIFDEVHYVNDQDRGVVWEEVIIMLPQHVKFILLSATVPNTYEFANWIGRTKQKNIYVISTPKRPVPLEINIWAKKELIPVINQNSEFLEANFRKHKEILNGESAKGAPSKTDNGRGGSTARGGRGGSNTRDGRGGRGNSTRGGANRGGSRGAGAIGSNKRKFFTQDGPSKKTWPEIVNYLRKRELLPMVVFVFSKKRCEEYADWLEGINFCNNKEKSQIHMFIEKSITRLKKEDRDLPQILKTRSLLERGIAVHHGGLLPIVKELIEILFSKGFIKVLFATETFAMGLNLPTRTVIFSSIRKHDGNGLRELTPGEFTQMAGRAGRRGLDSTGTVIVMAYNSPLSIATFKEVTMGVPTRLQSQFRLTYNMILNLLRIEALRVEEMIKYSFSENAKETLQPEHEKQIKVLQEELQTIEYKSCEICDNDIEKFLELMLAYKEATVNLMQEMVKSPSILHILKEGRLVAFRDPNDCLKLGFVFKVSLKDAVCVIMTFTKPYKLPNGEPNHLIYFPKADGYRRRNFPKFQKTDFYMEEVPVTAIEVITKRKFAAPLGKVIKKDVAALNEFNAETNNILDGKTLKEAINIEKQGLKIHQILLDRTNIRDEIFKLKSIKCPNLSQHIVPKFKAHVIKKKIEELYHLMSDQNLSLLPDYEKRLAVLKDTEFIDQNHNVLLKGRVACEINSGYELVLTELILDNFLGSFEPEEIVALLSVFVYEGKTREEEPPIVTPRLAKGKQRIEEIYKKMLCVFNTHQIPLTQDEAEFLDRKRFAMMNVVYEWARGLSFKEIMEMSPEAEGTVVRVITWLDEICREVKTASIIIGNSTLHMKMSRAQELIKRDIVFAASLYL", "length": 1287 }, "evidence": [ { "id": "RGD:1303059", "url": "https://alliancegenome.org/gene/RGD:1303059#orthology", "database": "AGR" }, { "id": "SGD:S000004390", "url": "https://alliancegenome.org/gene/SGD:S000004390#orthology", "database": "AGR" }, { "id": "MGI:1099835", "url": "https://alliancegenome.org/gene/MGI:1099835#orthology", "database": "AGR" }, { "id": "FB:FBgn0039117", "url": "https://alliancegenome.org/gene/FB:FBgn0039117#orthology", "database": "AGR" }, { "id": "HGNC:10898", "url": "https://alliancegenome.org/gene/HGNC:10898#orthology", "database": "AGR" }, { "id": "A0A0G2QC02", "url": "https://omabrowser.org/oma/group/A0A0G2QC02/", "database": "OMA" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q15477-1", "protein_name": "Superkiller complex protein 2", "gene_name": "SKIC2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MMETERLVLPPPDPLDLPLRAVELGCTGHWELLNLPGAPESSLPHGLPPCAPDLQQEAEQLFLSSPAWLPLHGVEHSARKWQRKTDPWSLLAVLGAPVPSDLQAQRHPTTGQILGYKEVLLENTNLSATTSLSLRRPPGPASQSLWGNPTQYPFWPGGMDEPTITDLNTREEAEEEIDFEKDLLTIPPGFKKGMDFAPKDCPTPAPGLLSLSCMLEPLDLGGGDEDENEAVGQPGGPRGDTVSASPCSAPLARASSLEDLVLKEASTAVSTPEAPEPPSQEQWAIPVDATSPVGDFYRLIPQPAFQWAFEPDVFQKQAILHLERHDSVFVAAHTSAGKTVVAEYAIALAQKHMTRTIYTSPIKALSNQKFRDFRNTFGDVGLLTGDVQLHPEASCLIMTTEILRSMLYSGSDVIRDLEWVIFDEVHYINDVERGVVWEEVLIMLPDHVSIILLSATVPNALEFADWIGRLKRRQIYVISTVTRPVPLEHYLFTGNSSKTQGELFLLLDSRGAFHTKGYYAAVEAKKERMSKHAQTFGAKQPTHQGGPAQDRGVYLSLLASLRTRAQLPVVVFTFSRGRCDEQASGLTSLDLTTSSEKSEIHLFLQRCLARLRGSDRQLPQVLHMSELLNRGLGVHHSGILPILKEIVEMLFSRGLVKVLFATETFAMGVNMPARTVVFDSMRKHDGSTFRDLLPGEYVQMAGRAGRRGLDPTGTVILLCKGRVPEMADLHRMMMGKPSQLQSQFRLTYTMILNLLRVDALRVEDMMKRSFSEFPSRKDSKAHEQALAELTKRLGALEEPDMTGQLVDLPEYYSWGEELTETQHMIQRRIMESVNGLKSLSAGRVVVVKNQEHHNALGVILQVSSNSTSRVFTTLVLCDKPLSQDPQDRGPATAEVPYPDDLVGFKLFLPEGPCDHTVVKLQPGDMAAITTKVLRVNGEKILEDFSKRQQPKFKKDPPLAAVTTAVQELLRLAQAHPAGPPTLDPVNDLQLKDMSVVEGGLRARKLEELIQGAQCVHSPRFPAQYLKLRERMQIQKEMERLRFLLSDQSLLLLPEYHQRVEVLRTLGYVDEAGTVKLAGRVACAMSSHELLLTELMFDNALSTLRPEEIAALLSGLVCQSPGDAGDQLPNTLKQGIERVRAVAKRIGEVQVACGLNQTVEEFVGELNFGLVEVVYEWARGMPFSELAGLSGTPEGLVVRCIQRLAEMCRSLRGAARLVGEPVLGAKMETAATLLRRDIVFAASLYTQ", "length": 1246 }, "evidence": [ { "id": "RGD:1303059", "url": "https://alliancegenome.org/gene/RGD:1303059#orthology", "database": "AGR" }, { "id": "SGD:S000004390", "url": "https://alliancegenome.org/gene/SGD:S000004390#orthology", "database": "AGR" }, { "id": "MGI:1099835", "url": "https://alliancegenome.org/gene/MGI:1099835#orthology", "database": "AGR" }, { "id": "FB:FBgn0039117", "url": "https://alliancegenome.org/gene/FB:FBgn0039117#orthology", "database": "AGR" }, { "id": "HGNC:10898", "url": "https://alliancegenome.org/gene/HGNC:10898#orthology", "database": "AGR" }, { "id": "A0A0G2QC02", "url": "https://omabrowser.org/oma/group/A0A0G2QC02/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q6NZR5-1", "protein_name": "Superkiller complex protein 2", "gene_name": "Skic2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MMETERLVLPPLDPLNLPLRALEVGCTGRWELLNVPGPPESTLPHGLPPCAPDLCQEAEQLFLSSPAWLPLHGVEHSARKWQRKTDPWSLLAAVETPVPSDLQAQRHPTTGHILGYKEVLLENTNLSATTSLSLRRPPGPASQSLWGNPTQYPFWPGGMDEPSITDLHTREEAEEEIDFEKDLLTVPPGFKKGVDFAPKDHPAPVPGLLSLSRLLEPLDLSGGDEDEGEAAGGPRGDNASPSPSGTPLVRASSLEDLVLKEAATVVSTPEPPKPPPQEQWAVPVDVTSPVGDFYRLIPQPAFQWAFEPDVFQKQAILHLEQHDSVFVAAHTSAGKTVVAEYAIALAQKHMTRTIYTSPIKALSNQKFRDFRNTFGDVGLLTGDVQLHPEASCLIMTTEILRSMLYSGSDVIRDLEWVIFDEVHYINDAERGVVWEEVLIMLPEHVSIILLSATVPNALEFADWIGRLKRRQIYVISTVARPVPLEHYLFTGNSPKTQGELFLLLDSRGAFHTQGYYAAVEAKKERMSKHAQTFGAKQPTHQGGPAQDRGVYLSLLASLRTRAQLPVVVFTFSRGRCDEQASGLTSLDLTTSSEKSEIHLFLQRCLARLRGSDRQLPQVLHMSELLRRGLGVHHSGILPILKEIVEMLFSRGLVKVLFATETFAMGVNMPARTVVFDSMRKHDGSTFRDLLPGEYVQMAGRAGRRGLDPTGTVILLCKGRVPEMADLHRMMMGKPSQLQSQFRLTYTMILNLLRVDALRVEDMMKRSFSEFPSRKDSKAHEQALADLTKRLGALEEPDVTGQLADLPEYYSWAEELTETQNMIQRRIMESVNGLKSLSVGRVVVVKNEEHHNALGVILQVSSNSTSRVFTTLVLCDKPVVSDNPRDKGPATPDVPHPDDLIGFKLFLPEGPCEHTVAKLQPGDVAAISTKVLRVNGEKISEDFSKRQQPKFRKDPPLAAVTTAVQELLRLAQSYPAGPPTLDPINDLQLKDVAVVEGGLRARKLEELIRGAQCVHSPRFPAQYVKLRERMQIQKEMERLRFLLSDQSLLLLPEYHQRVEVLRTLGYVDEAGTVKLAGRVACAMSSHELLLTELMFDNALSALRPEEIAALLSGLVCQSPGDPGDQLPSTLKQGVERVKAVAKRIGEVQVACGLNQTVEEFVGELNFGLVEVVYEWARGMPFSELAGLSGTPEGLVVRCIQRLAEMCRSLRGAARLVGEPVLGAKMETAATLLRRDIVFAASLYTQ", "length": 1244 }, "evidence": [ { "id": "RGD:1303059", "url": "https://alliancegenome.org/gene/RGD:1303059#orthology", "database": "AGR" }, { "id": "SGD:S000004390", "url": "https://alliancegenome.org/gene/SGD:S000004390#orthology", "database": "AGR" }, { "id": "MGI:1099835", "url": "https://alliancegenome.org/gene/MGI:1099835#orthology", "database": "AGR" }, { "id": "FB:FBgn0039117", "url": "https://alliancegenome.org/gene/FB:FBgn0039117#orthology", "database": "AGR" }, { "id": "HGNC:10898", "url": "https://alliancegenome.org/gene/HGNC:10898#orthology", "database": "AGR" }, { "id": "A0A0G2QC02", "url": "https://omabrowser.org/oma/group/A0A0G2QC02/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q86K90-1", "protein_name": "DEAD/DEAH box helicase", "gene_name": "", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MIELNIDSFLEELNNLENITSTNTTPVNKSNSSIKNNSNNTNVESFDLPNWYVNPTGLSAQPEITPIAPQSSIISPTIPNNCIQLFNFSDKEEILSDIRREYLDFSIESHKLNDDDEQKRQSYLIWPRNIDTDSWDFKLLAERTLSIPCSTVELVIDKIQYSISITNYHEVFLNTEKTSSNSTSLDRPWSNSISKDNFHRGNTSNLPFLPGGIKSPNNNSTNSTNNNNQTPIDWVQFWHSKSLLVKPPGLDNGILDFNENINKQDNKQQQQQQQQQQQQQQQQQQQQEKEKEEEEEVNLRYTLKDLEREIEEERKREEAEEAEVYEDDDQEDDLDIEEEELDELDDIEKTKEEIDDIIKSPPQPTSSSLSTSSSSSSTTLKDKNKIEIEIEEETKRKEEESKKEKQWAFLEQKEITSPLSDLITNPAIEYPFDLDSFQKQAIVHMEQGESVFITAHTSAGKTVIAEYAIAMAAKNMTRAIYTSPIKALSNQKFRDFKNTFNDVGLITGDVSISPSSSCLVLTTEILRSMLYKGADLIRDIEWVIFDEVHYLNDLERGVVWEEVIIMLPPYVKMVFLSATVSNPLEFAQWIGRTKQLPIYVIGTTKRPIPLEHYIHTPSNELFKIVDSNRNFLPSGYNSAYNSLYKTDNNKGGGGGGRGGHNQQQQQRGGSGNNISGWSKLINTLKDKQQLPVIIFSFSKNKCQEYAGSLGQSVNLTQGNEKSQIRVFIEQSLGRLCEDDKSLPQILQMKELLERGIGVHHGGLLPIVKELVEILFSKSLVKVLFATETFAMGVNMPAKTVVYSSTRKHDGITFRDLIPGEYTQMSGRAGRRGLDKVGTVIITYWKDIPEQATIESMILGTPSRLNSQFRLTYNMILNLLRVPDFKVEDMIKRSFSEFSSQKELPGIEKQIEKLQQQQKQLAQVDCILGEPDIDHYYKLFSQAKKYNQQIQNIILNLPNDNHLSIGRVVVLSTSSNIEKEVNDDDDDDDDNNDDDEIFENEKYTIGLILECKSTLIKQYTNTKVDRVFKIFSLKLKIENDIVLCVGNEIITSSGGKEIMKVCNEKLQLKQSDLKSILAGAESGGESEILINSLEQQLLRLIEEYPLPLGPKSIDPIKQLKLKDVDFVSTYDHLQSIEKLIPESKCHKCPRLHDHYEQTEKRYQLQYAIRDAKYTASDENLKLMPQFNIRLDILHELGYIDDENTVTLKGRVSREINTCEDLVITELIFENAFINLEPSEVVSVLSCLIFQEKDAVQPSLTPRLEEAKQNLIKTAEKTYKVESDKGLDVVPDDKLETTLKFGLMQVVYEWARGTPFNDICTLTNVLEGSIVRAITRIGETCQEVRNAARVIGDTKLLQKMEEAMRLIKRDIVFTSSLYVN", "length": 1378 }, "evidence": [ { "id": "A0A0G2QC02", "url": "https://omabrowser.org/oma/group/A0A0G2QC02/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9VCH8-1", "protein_name": "LD23303p", "gene_name": "tst", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MNEIRGEDNLERLRNYILRPELSLHNPLPDVLPRKFDPMRLLHAPRCPGSTKLAPRRDQSGHILEFVELDLEAVGANANNSMSMQREPGLLEDATRGSHSNFPFWPGGFDEQRQQIAALDVSNFQFGDKLLTVPPGFSSGYDFFQSQSVTLPPVVADPSNVDLLENLEQDLDVQEWMKLTRSEETSSTGTPKSPKQSNVQLPSEEFRDVDDHIMKADLKPVLNISTTTKNFKSDWAEMVDISQPINNFKEQIPCPAMDFPFELDVFQKQAILKLEQRQYVFVAAHTSAGKTVVAEYAIALSKRDLTRTIYTSPIKALSNQKYRDFRKTFKDVGLITGDLQIEPTASCLIMTTEILRSMLYCGSDVTRDLEWVIFDEVHYINNPERGHVWEEVIILLPEHVNIIMLSATVPNTLELADWVGSTKKRKVYVISTLKRPVPLTHFLYTGAGGKSRDDIFLLVDAQGKYLQGNYEKAVERKKEMQGKAKGGGGGPRNHLNAKQEQYTWIGLIDFLRRSNMMPVVAFTLSRNRCDSNLAALQSVDLNTEKEKGAVQKFFLQCLAKLKPPDRTIPQVLVLKDALERGIGVHHSGILPILKEIVEMLFQNGLVKLLFATETFAMGVNMPARTVVFDSCKKFDGLEMRNLKPGEYIQMAGRAGRRGHDETGTAIIMCKGSVPPSMELRPMILGLPEKLQSQFILRYAVILTCLRIESIKVEDIMKFSFKEFNLKLQLPTQQKQLRLAEDKFAMLPTLGEHLQPLVNFYDKAVEYWKEKHRIMKFVVTQPKIQKELKAGRVIVITQGKHYNKLAILLNTKSVPGKDTIYKVLVLDHQFKAKDSNSLQQGELYYKILSLTPRNMTFQPVGIGGHTVLDIKAIDIISITKSTLKVDADAIIRNWEQRQLERFKDSPPSGSVVKAVTELNQLNESYIDNPDNIKYVNLSKEIIVNADSEVAMLNYVDHLLRKVGEFLPHTNIAGFEQEFAKVYERRMLEIHIEELRFKNSARNLTLYPDYCNKLKVLRALKYIDELDEVTLKGKVACEMGQNELLITELILCNMFNDLEPAEIAALLSGLVFQAKMQDKPVIPEALKECVAAFEQINDTILAEEQRFQAAIETDNRLNFGLLEVVYEWARNKPFAEIMKLTTVQEGIIVRCIQQLNETLRDVKTAAIRIGNPGLQSKMEEASAAIKRDIVFTASLYTEL", "length": 1197 }, "evidence": [ { "id": "RGD:1303059", "url": "https://alliancegenome.org/gene/RGD:1303059#orthology", "database": "AGR" }, { "id": "SGD:S000004390", "url": "https://alliancegenome.org/gene/SGD:S000004390#orthology", "database": "AGR" }, { "id": "MGI:1099835", "url": "https://alliancegenome.org/gene/MGI:1099835#orthology", "database": "AGR" }, { "id": "FB:FBgn0039117", "url": "https://alliancegenome.org/gene/FB:FBgn0039117#orthology", "database": "AGR" }, { "id": "HGNC:10898", "url": "https://alliancegenome.org/gene/HGNC:10898#orthology", "database": "AGR" }, { "id": "A0A0G2QC02", "url": "https://omabrowser.org/oma/group/A0A0G2QC02/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "rescue of stalled ribosome", "id": "GO:0072344", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072344", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2QC02", "url": "https://www.uniprot.org/uniprotkb/A0A0G2QC02" } ], "pmid": "" }, { "name": "nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay", "id": "GO:0070478", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070478", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2QC02", "url": "https://www.uniprot.org/uniprotkb/A0A0G2QC02" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "Ski complex", "id": "GO:0055087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055087", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2QC02", "url": "https://www.uniprot.org/uniprotkb/A0A0G2QC02" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "RNA binding", "id": "GO:0003723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2QC02", "url": "https://www.uniprot.org/uniprotkb/A0A0G2QC02" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2QC02", "url": "https://www.uniprot.org/uniprotkb/A0A0G2QC02" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2QC02", "url": "https://www.uniprot.org/uniprotkb/A0A0G2QC02" } ], "pmid": "" }, { "name": "3'-5' RNA helicase activity", "id": "GO:0034458", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034458", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2QC02", "url": "https://www.uniprot.org/uniprotkb/A0A0G2QC02" } ], "pmid": "" }, { "name": "RNA helicase activity", "id": "GO:0003724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003724", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2QC02", "url": "https://www.uniprot.org/uniprotkb/A0A0G2QC02" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1153, "end_pos": 1155, "annotation": "n_glycosylation_sequon" }, { "start_pos": 125, "end_pos": 127, "annotation": "n_glycosylation_sequon" }, { "start_pos": 862, "end_pos": 864, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13065", "name": "", "equation": "ATP + H2O = ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D4A523-1", "Q3MHU3-1", "P60123-1", "Q793F9-1", "Q6P3V8-1", "F1LNJ2-1", "D4A2Z8-1", "E9PT29-1", "A0A8I5ZKX7-1", "G3V681-1", "G3V9M1-1", "A0A0G2K7X6-1", "A0A0G2K9N3-1", "F1M298-1", "A0A0G2K0E0-1", "Q5RKI1-1", "D4ADE8-1", "D3ZD73-1", "F1MAM8-1", "E9PTF0-1", "D4A031-1", "Q66HG7-1", "Q64060-1", "D4A7Q5-1", "M0R9C6-1", "P70486-1", "Q99PT0-1", "D3ZG52-1", "Q5U216-1", "Q62780-1", "Q641Y8-1", "Q5BJS0-1", "Q63413-1", "P06761-1", "Q6GX84-1", "Q5XI69-1", "Q9QUL6-1", "Q3B8Q2-1", "P46462-1", "Q68G38-1", "Q9QY16-1", "Q62724-1", "Q5EBA1-1", "Q3B8Q1-1", "Q9EQN5-1", "F1M5F3-1", "D3ZVK1-1", "F1M9L4-1", "F1MA70-1", "A0A8I5ZZZ0-1", "D3ZFP4-1", "A0A0G2K0H9-1", "D3ZBY5-1", "D3Z9Z9-1", "D3ZX56-1", "Q9WTT2-1", "Q8CG07-1", "P08289-1", "Q5XIR6-1", "B2GUX3-1", "D3ZHW0-1", "D3ZP96-1", "G3V8T5-1", "B1H269-1", "Q6VEU8-1", "Q5XI46-1", "A0A8I5ZKH1-1", "D3ZD46-1", "A0A096MJY0-1", "A0A096MJV7-1", "D3ZA12-1", "D4AAG9-1", "A0A0G2JTM6-1", "D4A321-1", "A0A8I6ABZ7-1", "E9PU01-1", "A0A8I5ZKV9-1", "D3ZD32-1", "P62738-1", "P63259-1", "P68035-1", "P68136-1", "P60711-1", "P63269-1", "P56536-1", "P54777-1", "Q6MG13-1", "D3ZSV6-1", "D3ZUC2-1", "A0A8I6GIY0-1", "D3ZD97-1", "A0A0G2K283-1", "D3ZAP7-1", "G3V6W5-1", "P63018-1", "P82995-1", "Q9JIX5-1", "D4A6Q6-1", "A0A8I6GIN4-1", "A6KAR2-1", "D4ADT5-1", "A6KSS8-1", "D4A2B7-1", "A0A8I6GF11-1", "D3ZH42-1", "A0A0G2K4S4-1", "F1LTR3-1", "F1LWY1-1", "P97687-1", "Q9JIL8-1", "Q925S8-1", "D4ACP5-1", "Q6AYJ1-1", "Q641Z7-1", "Q5EB68-1", "Q4G005-1", "A0A8I6AGW3-1", "Q5BKE0-1", "P34158-1", "Q7TT47-1", "M0RCB1-1", "D4A628-1", "Q5RJZ1-1", "Q3KRE0-1", "F1M3J4-1", "D3ZEG9-1", "G3V9T7-1", "A0A0G2K8J3-1", "A0A0G2K475-1", "P28480-1", "Q1HG60-1", "Q5XIM9-1", "B4F769-1", "Q68FQ0-1", "Q7TPB1-1", "Q8K1P7-1", "A0A8I6AKP6-1", "A0A0G2K7F0-1", "A1L1L6-1", "A0A8I6GH80-1", "D3ZZK7-1", "D4A5W5-1", "A0A0G2QC02-1", "P48721-1", "D4A474-1", "Q5U2U0-1", "Q6P502-1", "Q7TSA0-1", "Q66HD0-1", "A0A8I6GF73-1", "E9PT19-1", "F1LPQ2-1", "D3ZA68-1", "D4AAN8-1", "D4ADC2-1", "A0A8I5ZKZ9-1", "A0A8I6A2A6-1", "A0A0G2JZH9-1", "D3ZGJ0-1", "D3ZV87-1", "A0A8I5ZN47-1", "A0A8I5Y8G8-1", "D3ZYS7-1", "A0A8I6AUH3-1", "M0R9X1-1" ], "evidence": [ { "id": "13065", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13065" } ] }, { "id": "R-RNO-430028", "name": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-429974" ], "output_participant_list": [ "R-ALL-429926" ], "enzyme_list": [ "Q6AXM7-1", "A0A0G2QC02-1" ], "evidence": [ { "id": "R-RNO-430028", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-430028" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-429926", "participant_name": "capped oligoribonucleotide [cytosol]", "crossref": [ { "id": "33699", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-429974", "participant_name": "mature mRNA (eukaryotic, capped and deadenylated) [cytosol]", "crossref": [ { "id": "33699", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A096MJV7", "gene_name": "Chd9", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A096MJV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A096MJV7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A096MJV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A096MJV7" } ] } ] }, { "uniprot_ac": "A0A096MJY0", "gene_name": "Chd2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A096MJY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A096MJY0" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A096MJY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A096MJY0" } ] } ] }, { "uniprot_ac": "A0A0G2JTM6", "gene_name": "Dhx35", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A0G2JTM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JTM6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A0G2JTM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JTM6" } ] } ] }, { "uniprot_ac": "A0A0G2JZH9", "gene_name": "Dhx57", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A0G2JZH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JZH9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A0G2JZH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JZH9" } ] } ] }, { "uniprot_ac": "A0A0G2K0E0", "gene_name": "Ddx56", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A0G2K0E0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K0E0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A0G2K0E0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K0E0" } ] } ] }, { "uniprot_ac": "A0A0G2K0H9", "gene_name": "Ruvbl1-ps1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A0G2K0H9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K0H9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A0G2K0H9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K0H9" } ] } ] }, { "uniprot_ac": "A0A0G2K283", "gene_name": "Dhx8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A0G2K283", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K283" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A0G2K283", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K283" } ] } ] }, { "uniprot_ac": "A0A0G2K475", "gene_name": "Brip1", "activity": [ { "ec_number": "5.6.2.3", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A0G2K475", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K475" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0A0G2K475", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K475" } ] } ] }, { "uniprot_ac": "A0A0G2K4S4", "gene_name": "Ddx51", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A0G2K4S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K4S4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A0G2K4S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K4S4" } ] } ] }, { "uniprot_ac": "A0A0G2K7F0", "gene_name": "Fancm", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A0G2K7F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K7F0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A0G2K7F0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K7F0" } ] } ] }, { "uniprot_ac": "A0A0G2K7X6", "gene_name": "Ddx19a", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A0G2K7X6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K7X6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A0G2K7X6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K7X6" } ] } ] }, { "uniprot_ac": "A0A0G2K8J3", "gene_name": "Ddx11", "activity": [ { "ec_number": "5.6.2.3", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A0G2K8J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K8J3" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0A0G2K8J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K8J3" } ] } ] }, { "uniprot_ac": "A0A0G2K9N3", "gene_name": "Ddx3y", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A0G2K9N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K9N3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A0G2K9N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K9N3" } ] } ] }, { "uniprot_ac": "A0A0G2QC02", "gene_name": "Skic2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A0G2QC02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2QC02" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A0G2QC02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2QC02" } ] } ] }, { "uniprot_ac": "A0A8I5Y8G8", "gene_name": "Zgrf1", "activity": [ { "ec_number": "5.6.2.3", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A8I5Y8G8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8I5Y8G8" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0A8I5Y8G8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8I5Y8G8" } ] } ] }, { "uniprot_ac": "A0A8I5ZKH1", "gene_name": "Ythdc2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A8I5ZKH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZKH1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A8I5ZKH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZKH1" } ] } ] }, { "uniprot_ac": "A0A8I5ZKV9", "gene_name": "Ddx5", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A8I5ZKV9", "database": 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"evidence": [ { "id": "D3ZD97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZD97" } ] } ] }, { "uniprot_ac": "D3ZEG9", "gene_name": "Ercc2", "activity": [ { "ec_number": "5.6.2.3", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D3ZEG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZEG9" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "D3ZEG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZEG9" } ] } ] }, { "uniprot_ac": "D3ZFP4", "gene_name": "Mcm3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D3ZFP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZFP4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZFP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZFP4" } ] } ] }, { "uniprot_ac": "D3ZG52", "gene_name": "Dna2", 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"https://www.uniprot.org/uniprotkb/D3ZUC2" } ] } ] }, { "uniprot_ac": "D3ZV87", "gene_name": "Rad54l2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D3ZV87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZV87" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZV87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZV87" } ] } ] }, { "uniprot_ac": "D3ZVK1", "gene_name": "Mcm8", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D3ZVK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZVK1" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZVK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZVK1" } ] } ] }, { "uniprot_ac": "D3ZX56", "gene_name": "Ddx55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D3ZX56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZX56" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZX56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZX56" } ] } ] }, { "uniprot_ac": "D3ZYS7", "gene_name": "G3bp1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D3ZYS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZYS7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D3ZYS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZYS7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZYS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZYS7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZYS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZYS7" } ] } ] }, { "uniprot_ac": "D3ZZK7", "gene_name": "Myo3a", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "D3ZZK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZZK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "D3ZZK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZZK7" } ] } ] }, { "uniprot_ac": "D4A031", "gene_name": "Ddx42", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D4A031", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A031" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D4A031", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A031" } ] } ] }, { "uniprot_ac": "D4A2B7", "gene_name": "Afg2b", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D4A2B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A2B7" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "D4A2B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A2B7" } ] } ] }, { "uniprot_ac": "D4A2Z8", "gene_name": "Dhx36", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D4A2Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A2Z8" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D4A2Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A2Z8" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D4A2Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A2Z8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D4A2Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A2Z8" } ] } ] }, { "uniprot_ac": "D4A321", "gene_name": "Dhx38", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D4A321", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A321" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D4A321", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A321" } ] } ] }, { "uniprot_ac": "D4A474", "gene_name": "Dqx1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D4A474", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A474" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D4A474", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A474" } ] } ] }, { "uniprot_ac": "D4A523", "gene_name": "Nlrp3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "D4A523", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A523" } ] } ] }, { "uniprot_ac": "D4A5W5", "gene_name": "Recql4", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D4A5W5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A5W5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "D4A5W5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A5W5" } ] } ] }, { "uniprot_ac": "D4A628", "gene_name": "Polq", "activity": [ { "ec_number": "2.7.7.7", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "D4A628", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A628" } ] }, { "ec_number": "2.7.7.49", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "D4A628", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A628" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D4A628", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A628" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D4A628", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A628" } ] }, { "ec_number": "2.7.7.49", "activity": "", "evidence": [ { "id": "D4A628", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A628" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "D4A628", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A628" } ] } ] }, { "uniprot_ac": "D4A6Q6", "gene_name": "Ino80", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "D4A6Q6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A6Q6" } ] } ] }, { "uniprot_ac": "D4A7Q5", "gene_name": "Ddx28", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D4A7Q5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A7Q5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D4A7Q5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A7Q5" } ] } ] }, { "uniprot_ac": "D4AAG9", "gene_name": "Chd1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D4AAG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4AAG9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D4AAG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4AAG9" } ] } ] }, { "uniprot_ac": "D4AAN8", "gene_name": "Helb", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D4AAN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4AAN8" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D4AAN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4AAN8" } ] } ] }, { "uniprot_ac": "D4ACP5", "gene_name": "Recql5", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D4ACP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4ACP5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "D4ACP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4ACP5" } ] } ] }, { "uniprot_ac": "D4ADC2", "gene_name": "Helz2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D4ADC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4ADC2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D4ADC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4ADC2" } ] }, { "ec_number": "3.1.13.1", "activity": "Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.", "evidence": [ { "id": "D4ADC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4ADC2" } ] }, { "ec_number": "3.1.13.1", "activity": "", "evidence": [ { "id": "D4ADC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4ADC2" } ] } ] }, { "uniprot_ac": "D4ADE8", "gene_name": "Ddx3x", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D4ADE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4ADE8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D4ADE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4ADE8" } ] } ] }, { "uniprot_ac": "D4ADT5", "gene_name": "Rig1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D4ADT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4ADT5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D4ADT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4ADT5" } ] } ] }, { "uniprot_ac": "E9PT19", "gene_name": "Helq", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E9PT19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E9PT19" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E9PT19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E9PT19" } ] } ] }, { "uniprot_ac": "E9PT29", "gene_name": "Ddx17", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E9PT29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E9PT29" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E9PT29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E9PT29" } ] } ] }, { "uniprot_ac": "E9PTF0", "gene_name": "Ddx49", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E9PTF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E9PTF0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E9PTF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E9PTF0" } ] } ] }, { "uniprot_ac": "E9PU01", "gene_name": "Chd4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E9PU01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E9PU01" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E9PU01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E9PU01" } ] } ] }, { "uniprot_ac": "F1LNJ2", "gene_name": "Snrnp200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1LNJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1LNJ2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1LNJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1LNJ2" } ] } ] }, { "uniprot_ac": "F1LPQ2", "gene_name": "Ascc3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1LPQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1LPQ2" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1LPQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1LPQ2" } ] }, { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1LPQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1LPQ2" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1LPQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1LPQ2" } ] } ] }, { "uniprot_ac": "F1LTR3", "gene_name": "Tdrd12", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1LTR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1LTR3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1LTR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1LTR3" } ] } ] }, { "uniprot_ac": "F1LWY1", "gene_name": "Hfm1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1LWY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1LWY1" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1LWY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1LWY1" } ] } ] }, { "uniprot_ac": "F1M298", "gene_name": "Fbh1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1M298", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1M298" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1M298", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1M298" } ] } ] }, { "uniprot_ac": "F1M3J4", "gene_name": "Abcc4", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "F1M3J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1M3J4" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "F1M3J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1M3J4" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "F1M3J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1M3J4" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "F1M3J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1M3J4" } ] }, { "ec_number": "7.6.2.-", "activity": "", "evidence": [ { "id": "F1M3J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1M3J4" } ] }, { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1M3J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1M3J4" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1M3J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1M3J4" } ] } ] }, { "uniprot_ac": "F1M5F3", "gene_name": "Mcm9", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1M5F3", 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