{ "uniprot_canonical_ac": "A0A0G2KFP7-1", "uniprot_ac": "A0A0G2KFP7", "uniprot_id": "A0A0G2KFP7_DANRE", "mass": { "chemical_mass": 80257.0, "monoisotopic_mass": 80257.0 }, "refseq": { "ac": "XP_021322285", "name": "metal regulatory transcription factor 1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021322285" }, "gene_names": [ { "name": "mtf1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KFP7", "id": "A0A0G2KFP7" }, { "name": "MTF-1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021322285", "id": "XP_021322285" }, { "name": "MTF-1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KFP7", "id": "A0A0G2KFP7" }, { "name": "mtf1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021322285", "id": "XP_021322285" } ], "protein_names": [ { "name": "Metal regulatory transcription factor 1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KFP7/entry#names_and_taxonomy", "id": "A0A0G2KFP7" }, { "name": "MRE-binding transcription factor", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KFP7/entry#names_and_taxonomy", "id": "A0A0G2KFP7" }, { "name": "Transcription factor MTF-1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KFP7/entry#names_and_taxonomy", "id": "A0A0G2KFP7" }, { "name": "metal regulatory transcription factor 1 isoform X1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021322285", "id": "XP_021322285" } ], "function": [ { "annotation": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Full annotation Annotation Name :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133191) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length.", "evidence": [ { "database": "RefSeq", "id": "XP_021322285", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021322285" } ] }, { "annotation": "Zinc-dependent transcriptional regulator of cellular adaption to conditions of exposure to heavy metals. Binds to metal responsive elements (MRE) in promoters and activates the transcription of metallothionein genes like metallothionein-2/MT2A. Also regulates the expression of metalloproteases in response to intracellular zinc and functions as a catabolic regulator of cartilages.", "evidence": [ { "database": "UniProtKB", "id": "Q8QGH4", "url": "https://www.uniprot.org/uniprotkb/Q8QGH4#function" }, { "database": "UniProtKB", "id": "ARBA00056278", "url": "https://www.uniprot.org/uniprotkb/ARBA00056278#function" }, { "database": "UniProtKB", "id": "A0A0G2KFP7", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KFP7#function" }, { "database": "UniProtKB", "id": "A0A0B5H7U7", "url": "https://www.uniprot.org/uniprotkb/A0A0B5H7U7#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Danio rerio", "taxid": 7955, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KFP7", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KFP7" } ], "common_name": "Zebrafish", "glygen_name": "Zebrafish", "reference_species": "Danio rerio [7955]" } ], "gene": [ { "name": "mtf1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KFP7", "locus": {} } ], "crossref": [ { "id": "ZFIN:ZDB-GENE-020424-1", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-020424-1", "database": "AGR", "categories": [ "Protein Classification" ] }, { "id": "ENSDARG00000102898", "url": "https://bgee.org/?page=gene&gene_id=ENSDARG00000102898", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "195821", "url": "https://www.ncbi.nlm.nih.gov/gene/195821", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051061", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051061", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dre:195821", "url": "https://www.genome.jp/dbget-bin/www_bget?dre:195821", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "KGHLYNA", "url": "https://omabrowser.org/oma/group/KGHLYNA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A0G2KFP7", "url": "https://www.orthodb.org/?gene=A0A0G2KFP7", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "Q8QGH4", "url": "https://www.orthodb.org/?gene=Q8QGH4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46179", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46179", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46179:SF25", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46179:SF25", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00096", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "XP_021322285", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_021322285", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A0B5H7U7", "url": "https://www.uniprot.org/uniprotkb/A0A0B5H7U7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0B5H7U7-1", "url": "https://www.uniprot.org/uniprotkb/A0A0B5H7U7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2KFP7", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KFP7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2KFP7-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KFP7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8QGH4", "url": "https://www.uniprot.org/uniprotkb/Q8QGH4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8QGH4-1", "url": "https://www.uniprot.org/uniprotkb/Q8QGH4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "ZDB-GENE-020424-1", "url": "https://zfin.org/ZDB-GENE-020424-1", "database": "ZFIN", "categories": [ "Protein", "Organism-specific" ] } ], "sequence": { "sequence": "MTGASIYRRNKSTHVDTNPGLSFSVRIMGENGPLSETAMLFEDEEEDVDKLGREEEDEDKMANFDKDGNMISGPSSSSGTVYDRTTVLIEQDPIRLDEEGEEDGMTFLPEGEGDEGSLAFMGDPDGMSQGYIHHTISPDQIQFIINPGSTPMPRNIEGATLTLHSECPETKQREVKRYQCLFEGCTRTYSTAGNLRTHQKTHRGEYTFVCNQQGCGKAFLTSYSLKIHVRVHTKEKPFECDVQGCEKAFNTLYRLKAHQRLHTGKTFNCESEGCTKYFTTLSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGEKPFFCPSDGCEKTFSSQYSLKSHIRGHDKGPSFTVSSHPLSEDANHSLCLSDLSLISTDSELQENHNSQGLDLNSVTPIRIFELMFQSPENSVSEDDPKPTESLAESFGLEPSPQTAPADASTHPAFPQPPPSTCSSSCSITAPAQDAQTPPTTQQAPPPAVSSSSQTSSFPSAPPSSSQPAEVSSPSAPSATQHYMMAQPVSSPSAASVSSVPAGTAEVTAAVTHTVPLAAPPTISIAPTLGLQPSLVMSDQNLQWILSSAASAQQNPEQQGPKVEKVFFTTAIPVGGNSGNAVQQIGLSLPVIIIKQEESCQCHCACRDSAKDKSTSSSQDKTKNTSPPPPPAPPPPPPALPKEPPSCCPSKPHTQPQQDLPTAPLTPNPPTDALGSMDVSDLLSPETTANIEALLMVADGFSMADGGGSGAP", "length": 749, "header": "tr|A0A0G2KFP7-1|A0A0G2KFP7_DANRE Isoform 1 of Metal regulatory transcription factor 1 OS=Danio rerio OX=7955 GN=mtf1 PE=4 SV=2 CANONICAL=A0A0G2KFP7-1" }, "isoforms": [ { "isoform_ac": "A0A0B5H7U7-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KFP7/entry#A0A0B5H7U7-1", "sequence": { "sequence": "MGENGPLSETAMLFEDEEEDVDKLGREEEDEDKMANFDKDGNMISGPSSSSGTVYDRTTVLIEQDPIRLDEEGEEDGMTFLPEGEGDEGSLAFMGDPDGMSQGYIHHTISPDQIQFIINPGSTPMPRNIEGATLTLHSECPETKQREVKRYQCLFEGCTRTYSTAGNLRTHQKTHRGEYTFVCNQQGCGKAFLTSYSLKIHVRVHTKEKPFECDVQGCEKAFNTLYRLKAHQRLHTGKTFNCESEGCTKYFTTLSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGEKPFFCPSDGCEKTFSSQYSLKSHIRGHDKGPSFTVSSHPLSEDANHSLCLSDLSLISTDSELQENHNSQGLDLNSVTPIRIFELMFQSPENSVSEDDPKPTESLAESFGLEPSPQTAPADASTHPAFPQPPPSTCSSSCSITAPAQDAQTPPTTQQAPPPAVSSSSQTSSFPSAPPSSSQPAEVSSPSAPSATQHYMMAQPVSSPSAASVSSVPAGTAEVTAAVTHTVPLAAPPTISIAPTLGLQPSLVMSDQNLQWILSSAASAQQNPEQQGPKVEKVFFTTAIPVGGNSGNAVQQIGLSLPVIIIKQEESCQCHCACRDSAKDKSTSSSQDKTKNTSPPPPPAPPPPPPALPKEPPSCCPSKPHTQPQQDLPTAPLTPNPPTDALGSMDVSDLLSPETTANIEALLMVADGFSMADGGGSGAP", "length": 722, "header": "tr|A0A0B5H7U7-1|A0A0B5H7U7_DANRE Computationally mapped isoform of Metal regulatory transcription factor 1 OS=Danio rerio OX=7955 GN=mtf1 PE=2 SV=1 CANONICAL=A0A0G2KFP7-1" }, "locus": {} }, { "isoform_ac": "A0A0G2KFP7-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KFP7/entry#A0A0G2KFP7-1", "sequence": { "sequence": "MTGASIYRRNKSTHVDTNPGLSFSVRIMGENGPLSETAMLFEDEEEDVDKLGREEEDEDKMANFDKDGNMISGPSSSSGTVYDRTTVLIEQDPIRLDEEGEEDGMTFLPEGEGDEGSLAFMGDPDGMSQGYIHHTISPDQIQFIINPGSTPMPRNIEGATLTLHSECPETKQREVKRYQCLFEGCTRTYSTAGNLRTHQKTHRGEYTFVCNQQGCGKAFLTSYSLKIHVRVHTKEKPFECDVQGCEKAFNTLYRLKAHQRLHTGKTFNCESEGCTKYFTTLSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGEKPFFCPSDGCEKTFSSQYSLKSHIRGHDKGPSFTVSSHPLSEDANHSLCLSDLSLISTDSELQENHNSQGLDLNSVTPIRIFELMFQSPENSVSEDDPKPTESLAESFGLEPSPQTAPADASTHPAFPQPPPSTCSSSCSITAPAQDAQTPPTTQQAPPPAVSSSSQTSSFPSAPPSSSQPAEVSSPSAPSATQHYMMAQPVSSPSAASVSSVPAGTAEVTAAVTHTVPLAAPPTISIAPTLGLQPSLVMSDQNLQWILSSAASAQQNPEQQGPKVEKVFFTTAIPVGGNSGNAVQQIGLSLPVIIIKQEESCQCHCACRDSAKDKSTSSSQDKTKNTSPPPPPAPPPPPPALPKEPPSCCPSKPHTQPQQDLPTAPLTPNPPTDALGSMDVSDLLSPETTANIEALLMVADGFSMADGGGSGAP", "length": 749, "header": "tr|A0A0G2KFP7-1|A0A0G2KFP7_DANRE Isoform 1 of Metal regulatory transcription factor 1 OS=Danio rerio OX=7955 GN=mtf1 PE=4 SV=2 CANONICAL=A0A0G2KFP7-1" }, "locus": {} }, { "isoform_ac": "Q8QGH4-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KFP7/entry#Q8QGH4-1", "sequence": { "sequence": "MGENGPLSETAMLFEDEEEDVDKLGREEEDEDKMANFDKDGNMISGPSSSSGTVYDRTTVLIEQDPIRLDEEGEEDGMTFLPEGEGDEGSLAFMGDPDGMSQGYIHHTISPDQIQFIINPGSTPMPRNIEGATLTLHSECPETKQREVKRYQCLFEGCTRTYSTAGNLRTHQKTHRGEYTFVCNQQGCGKAFLTSYSLKIHVRVHTKEKPFECDVQGCEKAFNTLYRLKAHQRLHTGKTFNCESEGCTKYFTTLSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGEKPFFCPSDGCEKTFSSQYSLKSHIRGHDKGPSFTVSGHPLSEDANHSLCLSDLSLISTDSELQENHNSQGLDLNSVTPIRIFELMFQSPENSVSEDDPKPTESLAESFGLEPSPQSAPADASTHPAFPQPPPSTCSSSCSITAPAQDAQTPPTTQQAPPPAVSSSSQTSSFPSAPPSSSQPAEVSSPSAPSATQHYMMAQSVSSPSAASVSSVPAGTAEVTAAVTHTVPLAAPPTISIAPTLGLQPSLVMSDQNLQWILSSAASAQQNPEQQGPKVEKVFFTTAIPVGGNSGMIGY", "length": 593, "header": "tr|Q8QGH4-1|Q8QGH4_DANRE Computationally mapped isoform of Metal regulatory transcription factor 1 OS=Danio rerio OX=7955 GN=mtf1 PE=2 SV=1 CANONICAL=A0A0G2KFP7-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "start_pos": 150, "start_aa": "Thr", "end_pos": 150, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr150", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "00000000000000001000.00000000001000.0.xxxxx" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Characterization of the MTF-1 transcription factor from zebrafish and trout cells.", "journal": "Comp. Biochem. Physiol. B, Biochem. Mol. Biol.", "date": "2000", "authors": "Dalton T P, Solis W A, Nebert D W, Carvan M J", "evidence": [ { "database": "UniProtKB", "id": "Q8QGH4", "url": "https://www.uniprot.org/uniprotkb/Q8QGH4" } ], "reference": [ { "type": "PubMed", "id": "11007174", "url": "https://glygen.org/publication/PubMed/11007174" } ] }, { "title": "Molecular cloning and developmental expression of zinc finger transcription factor MTF-1 gene in zebrafish, Danio rerio.", "journal": "Biochem. Biophys. Res. Commun.", "date": "2002", "authors": "Chen Wen-Ya, John Joseph Abraham Christopher, Lin Chen-Hui, Chang Chi-Yao", "evidence": [ { "database": "UniProtKB", "id": "Q8QGH4", "url": "https://www.uniprot.org/uniprotkb/Q8QGH4" } ], "reference": [ { "type": "PubMed", "id": "11866436", "url": "https://glygen.org/publication/PubMed/11866436" } ] }, { "title": "Expression pattern of metallothionein, MTF-1 nuclear translocation, and its dna-binding activity in zebrafish (Danio rerio) induced by zinc and cadmium.", "journal": "Environ. Toxicol. Chem.", "date": "2007", "authors": "Chen Wen-Ya, John Joseph Abraham Christopher, Lin Cheng-Hui, Chang Chi-Yao", "evidence": [ { "database": "UniProtKB", "id": "Q8QGH4", "url": "https://www.uniprot.org/uniprotkb/Q8QGH4" } ], "reference": [ { "type": "PubMed", "id": "17269467", "url": "https://glygen.org/publication/PubMed/17269467" } ] }, { "title": "Exposure to copper nanoparticles causes gill injury and acute lethality in zebrafish (Danio rerio).", "journal": "Environ. Sci. Technol.", "date": "2007", "authors": "Griffitt Robert J, Weil Roxana, Hyndman Kelly A, Denslow Nancy D, Powers Kevin, Taylor David, Barber David S", "evidence": [ { "database": "UniProtKB", "id": "Q8QGH4", "url": "https://www.uniprot.org/uniprotkb/Q8QGH4" } ], "reference": [ { "type": "PubMed", "id": "18186356", "url": "https://glygen.org/publication/PubMed/18186356" } ] }, { "title": "Cytotoxicities and induction of metallothionein (MT) and metal regulatory element (MRE)-binding transcription factor-1 (MTF-1) messenger RNA levels in the zebrafish (Danio rerio) ZFL and SJD cell lines after exposure to various metal ions.", "journal": "Aquat. Toxicol.", "date": "2008", "authors": "Cheuk Wai Ka, Chan Patrick Chung-Yiu, Chan King Ming", "evidence": [ { "database": "UniProtKB", "id": "Q8QGH4", "url": "https://www.uniprot.org/uniprotkb/Q8QGH4" } ], "reference": [ { "type": "PubMed", "id": "18639347", "url": "https://glygen.org/publication/PubMed/18639347" } ] }, { "title": "Zinc-controlled gene expression by metal-regulatory transcription factor 1 (MTF1) in a model vertebrate, the zebrafish.", "journal": "Biochem. Soc. Trans.", "date": "2008", "authors": "Hogstrand Christer, Zheng Dongling, Feeney Graham, Cunningham Phil, Kille Peter", "evidence": [ { "database": "UniProtKB", "id": "Q8QGH4", "url": "https://www.uniprot.org/uniprotkb/Q8QGH4" } ], "reference": [ { "type": "PubMed", "id": "19021535", "url": "https://glygen.org/publication/PubMed/19021535" } ] }, { "title": "The zebrafish reference genome sequence and its relationship to the human genome.", "journal": "Nature", "date": "2013", "authors": "Howe Kerstin, Clark Matthew D, Torroja Carlos F, Torrance James, Berthelot Camille, Muffato Matthieu, Collins John E, Humphray Sean, McLaren Karen, Matthews Lucy, McLaren Stuart, Sealy Ian, Caccamo Mario, Churcher Carol, Scott Carol, Barrett Jeffrey C, Koch Romke, Rauch Gerd-J\u00f6rg, White Simon, Chow William, Kilian Britt, Quintais Leonor T, Guerra-Assun\u00e7\u00e3o Jos\u00e9 A, Zhou Yi, Gu Yong, Yen Jennifer, Vogel Jan-Hinnerk, Eyre Tina, Redmond Seth, Banerjee Ruby, Chi Jianxiang, Fu Beiyuan, Langley Elizabeth, Maguire Sean F, Laird Gavin K, Lloyd David, Kenyon Emma, Donaldson Sarah, Sehra Harminder, Almeida-King Jeff, Loveland Jane, Trevanion Stephen, Jones Matt, Quail Mike, Willey Dave, Hunt Adrienne, Burton John, Sims Sarah, McLay Kirsten, Plumb Bob, Davis Joy, Clee Chris, Oliver Karen, Clark Richard, Riddle Clare, Elliot David, Eliott David, Threadgold Glen, Harden Glenn, Ware Darren, Begum Sharmin, Mortimore Beverley, Mortimer Beverly, Kerry Giselle, Heath Paul, Phillimore Benjamin, Tracey Alan, Corby Nicole, Dunn Matthew, Johnson Christopher, Wood Jonathan, Clark Susan, Pelan Sarah, Griffiths Guy, Smith Michelle, Glithero Rebecca, Howden Philip, Barker Nicholas, Lloyd Christine, Stevens Christopher, Harley Joanna, Holt Karen, Panagiotidis Georgios, Lovell Jamieson, Beasley Helen, Henderson Carl, Gordon Daria, Auger Katherine, Wright Deborah, Collins Joanna, Raisen Claire, Dyer Lauren, Leung Kenric, Robertson Lauren, Ambridge Kirsty, Leongamornlert Daniel, McGuire Sarah, Gilderthorp Ruth, Griffiths Coline, Manthravadi Deepa, Nichol Sarah, Barker Gary, Whitehead Siobhan, Kay Michael, Brown Jacqueline, Murnane Clare, Gray Emma, Humphries Matthew, Sycamore Neil, Barker Darren, Saunders David, Wallis Justene, Babbage Anne, Hammond Sian, Mashreghi-Mohammadi Maryam, Barr Lucy, Martin Sancha, Wray Paul, Ellington Andrew, Matthews Nicholas, Ellwood Matthew, Woodmansey Rebecca, Clark Graham, Cooper James D, Cooper James, Tromans Anthony, Grafham Darren, Skuce Carl, Pandian Richard, Andrews Robert, Harrison Elliot, Kimberley Andrew, Garnett Jane, Fosker Nigel, Hall Rebekah, Garner Patrick, Kelly Daniel, Bird Christine, Palmer Sophie, Gehring Ines, Berger Andrea, Dooley Christopher M, Ersan-\u00dcr\u00fcn Z\u00fcbeyde, Eser Cigdem, Geiger Horst, Geisler Maria, Karotki Lena, Kirn Anette, Konantz Judith, Konantz Martina, Oberl\u00e4nder Martina, Rudolph-Geiger Silke, Teucke Mathias, Lanz Christa, Raddatz G\u00fcnter, Osoegawa Kazutoyo, Zhu Baoli, Rapp Amanda, Widaa Sara, Langford Cordelia, Yang Fengtang, Schuster Stephan C, Carter Nigel P, Harrow Jennifer, Ning Zemin, Herrero Javier, Searle Steve M J, Enright Anton, Geisler Robert, Plasterk Ronald H A, Lee Charles, Westerfield Monte, de Jong Pieter J, Zon Leonard I, Postlethwait John H, N\u00fcsslein-Volhard Christiane, Hubbard Tim J P, Roest Crollius Hugues, Rogers Jane, Stemple Derek L", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KFP7", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KFP7" } ], "reference": [ { "type": "PubMed", "id": "23594743", "url": "https://glygen.org/publication/PubMed/23594743" } ] }, { "title": "Inhibition of endogenous MTF-1 signaling in zebrafish embryos identifies novel roles for MTF-1 in development.", "journal": "Biochim. Biophys. Acta", "date": "2014", "authors": "O'Shields Britton, McArthur Andrew G, Holowiecki Andrew, Kamper Martin, Tapley Jeffrey, Jenny Matthew J", "evidence": [ { "database": "UniProtKB", "id": "A0A0B5H7U7", "url": "https://www.uniprot.org/uniprotkb/A0A0B5H7U7" } ], "reference": [ { "type": "PubMed", "id": "24751692", "url": "https://glygen.org/publication/PubMed/24751692" } ] }, { "title": "Negative effects of acute cadmium on stress defense, immunity, and metal homeostasis in liver of zebrafish: The protective role of environmental zinc dpre-exposure.", "journal": "Chemosphere", "date": "2019", "authors": "Wang Cheng-Cheng, Si Lan-Fang, Guo Sai-Nan, Zheng Jia-Lang", "evidence": [ { "database": "UniProtKB", "id": "Q8QGH4", "url": "https://www.uniprot.org/uniprotkb/Q8QGH4" } ], "reference": [ { "type": "PubMed", "id": "30690405", "url": "https://glygen.org/publication/PubMed/30690405" } ] }, { "title": "A holistic study on potential toxic effects of carboxylated multi-walled carbon nanotubes (MWCNTs-COOH) on zebrafish (Danio rerio) embryos/larvae.", "journal": "Chemosphere", "date": "2019", "authors": "Icoglu Aksakal Feyza, Ciltas Abdulkadir, Simsek Ozek Nihal", "evidence": [ { "database": "UniProtKB", "id": "Q8QGH4", "url": "https://www.uniprot.org/uniprotkb/Q8QGH4" } ], "reference": [ { "type": "PubMed", "id": "30904762", "url": "https://glygen.org/publication/PubMed/30904762" } ] }, { "title": "Impact of copper oxide nanoparticles (CuO NPs) exposure on embryo development and expression of genes related to the innate immune system of zebrafish (Danio rerio).", "journal": "Comp. Biochem. Physiol. C Toxicol. Pharmacol.", "date": "2019", "authors": "Aksakal Feyza Icoglu, Ciltas Abdulkadir", "evidence": [ { "database": "UniProtKB", "id": "Q8QGH4", "url": "https://www.uniprot.org/uniprotkb/Q8QGH4" } ], "reference": [ { "type": "PubMed", "id": "31158555", "url": "https://glygen.org/publication/PubMed/31158555" } ] }, { "title": "The evolution and immunomodulatory role of Zc3h12 proteins in zebrafish (Danio rerio).", "journal": "Int. J. Biol. Macromol.", "date": "2023", "authors": "Yang Shuaiqi, Xu Xinyi, Zhang Ailong, Wang Yunchao, Ji Guangdong, Sun Chen, Li Hongyan", "evidence": [ { "database": "UniProtKB", "id": "Q8QGH4", "url": "https://www.uniprot.org/uniprotkb/Q8QGH4" } ], "reference": [ { "type": "PubMed", "id": "37001786", "url": "https://glygen.org/publication/PubMed/37001786" } ] }, { "title": "Genome-wide screening in pluripotent cells identifies Mtf1 as a suppressor of mutant huntingtin toxicity.", "journal": "Nat. Commun.", "date": "2023", "authors": "Ferlazzo Giorgia Maria, Gambetta Anna Maria, Amato Sonia, Cannizzaro Noemi, Angiolillo Silvia, Arboit Mattia, Diamante Linda, Carbognin Elena, Romani Patrizia, La Torre Federico, Galimberti Elena, Pflug Florian, Luoni Mirko, Giannelli Serena, Pepe Giuseppe, Capocci Luca, Di Pardo Alba, Vanzani Paola, Zennaro Lucio, Broccoli Vania, Leeb Martin, Moro Enrico, Maglione Vittorio, Martello Graziano", "evidence": [ { "database": "UniProtKB", "id": "Q8QGH4", "url": "https://www.uniprot.org/uniprotkb/Q8QGH4" } ], "reference": [ { "type": "PubMed", "id": "37407555", "url": "https://glygen.org/publication/PubMed/37407555" } ] } ], "pathway": [ { "id": "dre:195821", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?dre:195821", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A5G2Q8U0-1", "protein_name": "Metal regulatory transcription factor 1", "gene_name": "MTF1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGEHSPDNSISYFEAEEDELTPDDKMLRFVDKNGLVPSSSGTVYDRTTVLIEQDPGTLEDDDDDGQCGEHLPFLVGGEEGFHLIDHEAMSQGYVQHIISPDQIHLTINPGSTPMPRNIEGATLTLQSECPETKRKEVKRYQCTFEGCPRTYSTAGNLRTHQKTHRGEYTFVCNQEGCGKAFLTSYSLRIHVRVHTKEKPFECDVQGCEKAFNTLYRLKAHQRLHTGKTFNCESEGCSKYFTTLSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFCPSNGCEKTFSTQYSLKSHMKGHDNKGHSYSALLNHNGSEDTNHSLCLRNLSLLSTDSEFQENSSTGQNLSTLSPTILFGPMFQKPEDTAIQEDPQQTAALIESFNGDAESVSDVPPSSRHSASLSLPLVLQPGLSEPPQPLLPASAPSAPLPAPSLGTGSQQAAFGNPPALLQPPEVPVPHSTQFAANHQEFLPHPQAPQPGLSVPGLSVVAGALASAMAAPPQPQSTTEPLPAMVQTLPLDANSVLTSNPTITITPTPSTAILQPSLVMGEQNLQWILNGATSSPQTQEQIQQASKVEKVFFTTAVPVASSTGSAVQQIGLSVPVIIIKQEEACQCQCACRDSAKERAASRRKGCSSPPPPELSAQPPDGPGLKLPPQTFSPPPIPLSSSSAASSSCEQSRQAVTPSDPPTETLRAMDMSEFLSLQSLDTPSNLIPIEALLQEEEEMGLTSSFSK", "length": 747 }, "evidence": [ { "id": "A0A0G2KFP7", "url": "https://omabrowser.org/oma/group/A0A0G2KFP7/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A8JNP3-1", "protein_name": "Metal response element-binding transcription Factor-1, isoform C", "gene_name": "MTF-1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MNDQEKQHQQQQQHYFHSEWKTTANSHGNSLSDSRDYDTNSSRNSLSGSPPVTSNCSSSGSLDFDRPLAQLLEPKLEADGLGIIHGDNYSIYGSQTAESTSGEQQVLNLGLTLDTGDAQATYGDLFGAQDQLTASQTHGHSQVVVSAAADNAFSLADQLTPLPITVIPITYHHTTENLSSSHSEVPLIASLSDITAQVFNLDDICFTLEYQFENQRLVQVQPPTVVSLSMVSSPNEAANPPINCDNDQGTGNSISRDSTSNSPAYFTIETSYVDEYDPNEPDEDEQLAHCIQPGVLHQDVDEEEVERQDENDQLMALAYESSDEALSRYRCNYENCYRSYSTIGNLRTHLKTHTGDYSFKCPEDGCHKAFLTSYSLKIHVRVHTKVKPYECEVSGCDKAFNTRYRLHAHLRLHNGETFNCELCQKCFTTLSDLKKHMRTHTQERPYKCPEDDCGKAFTASHHLKTHRRTHTGEKPYPCQEDSCQKSFSTSHSLKSHKKTHQRQLQNKGRKKRPLKTQQTKCSDQEQKDPQQEEQEEEEFIKEDQPEMTLLNPGSHCSETTSTDSGVVLQTLTPQDHLSNVFILQGNEPLILPETSQAYQLSYAAEEEIPSPWIDAGVLVSKPIIPMAPLTDACVALPTEMPSFVNLKPTFGNAVSGNMGDPQPETMDVDPTVETSLPTPTLELNQPNIEELLKQDSFENEEDMETESLLNDILMTIDNNSALLQATLQQASQVPSDASGLVELDIRDNKPTLKQITADAGICNCTNCKCDQTKSCHGGDCGAAAAQQTTRTGAPTTTTTTTTMNSSGGKRICGSVVPTKKVSKRETEMNQNIEDVALLLQNLASMSSGGSSGGGGGCCGGGAVKPAPSGGGCCGEPKAPKPVNAGCGCARPSAPSSGGCCGSGVASTPKPTGGCCSGNQKPAPTATAASSPSCCCSGKGEVQEPPVISSASSAPAAAVKGNACTCKSPAEGVANGCCVVICIKTLQALRKVLTRRNLNLMLCPQQN", "length": 1006 }, "evidence": [ { "id": "HGNC:7428", "url": "https://alliancegenome.org/gene/HGNC:7428#orthology", "database": "AGR" }, { "id": "MGI:101786", "url": "https://alliancegenome.org/gene/MGI:101786#orthology", "database": "AGR" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "D3ZBT4-1", "protein_name": "Metal regulatory transcription factor 1", "gene_name": "Mtf1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGEHSPDDNIIFFKGEEDDLTPHDKMLRFVDDNGLVPSSSGTVYDRTTVLIEQDPGTLEDDEDDVQCGEHLPFLVEGEEGFLIDQEAMSQGYVQHIISPDQIHLTINPGSTPMPRNIEGATLTLQSECPETKRKEVKRYQCTFEGCPRTYSTAGNLRTHQKTHRGEYTFVCNQEGCGKAFLTSYSLRIHVRVHTKEKPFECDVQGCEKAFNTLYRLKAHQRLHTGKTFNCESQGCSKYFTTLSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFCPSNGCEKTFSTQYSLKSHMKGHDNKGTAYSALPQHNGSEDTNHSLYLSELGLLSTDSELQENSSSTQDQDLSTISPAIIFESMFQNPDDPAIQDDPLHTAALIDSFNGDAESVSDVPPPAGNSASLSLPLVLQPGISEPPQPLLPASTPSAPPPAPSLGPGSQPAAFGSPPALLQPPEVPVPHSTQFAANHQEFLPHPQAPPQTIVPGLSVVAGAPASAATVASAVAAPAPPQSTTEPLPAMVQTLPLGANSVLTNNPTITITPTPNTAILQSSLVMGEQNLQWILNGATSSPQNQEQIQQASKVEQVYFTTAVPVASSTGSSVQQIGLSVPVIIIKQEEACQCQCACRDSAKERAAGRRKGCSSPPPPEPNPQPPDGPSLQLPP", "length": 675 }, "evidence": [ { "id": "HGNC:7428", "url": "https://alliancegenome.org/gene/HGNC:7428#orthology", "database": "AGR" }, { "id": "MGI:101786", "url": "https://alliancegenome.org/gene/MGI:101786#orthology", "database": "AGR" }, { "id": "A0A0G2KFP7", "url": "https://omabrowser.org/oma/group/A0A0G2KFP7/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P47043-1", "protein_name": "Zinc-responsive transcriptional regulator ZAP1", "gene_name": "ZAP1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MDALTPRDSPKRDDSMATSAATAASAKPDALTIGKEGIVHGHIHNYNNLTYIHGHLHHSAPVNDSSASATPAAAAVADAATSAFASGASHDMGGDCHVNEKCKEYTDCQHFEFLNYHNNPSLTKYNDTATYNSNNHSFANNFHSVASDPTSPQQNSKSDLPRRKDSWFNDDLILLPSSKKNKPNPPPGSDDCYCTPKILEICCDETHPKSEANIKQGESDQPTKKDISENGNDVAIFTDVKNDHLMPNFNLHDQYCNSTNHDSHNHNNTVPDSFSQLMSHLSEIDCDLTCDTPCTASTSATSGHKFVQDHQSSNNDDVFHKYCKFCEESTDNQPCSKHMHLESKPPQLPPKCSSLRKPTNTLQGTNHAYHEHILNTDMDLKILEDLCNISSLYEVPFGKHINHHDHNNAGNGCDGSSTGNNENGNQTMNLLLSSINRCNPKNNLNGSNNNTAGATSTDHQHHHHRIQFHSHKPNRNNIVNNSGISAANTTADLTNNDLNDLISREYSYERFRNQSEPPSLPKVTHQNQKNRRSWPTKDLESTDFSSLEDSLPSSISPPIQTTSTINFNWCFKEEKNNDLKCKWKECPESCSSLFDLQRHLLKDHVSQDFKHPMEPLACNWEDCDFLGDDTCSIVNHINCQHGINFDIQFANPDSFLPGSISKEKHHLLHCPNPQTHEVSKADGAPDMTSANDVSNIPPIKQPEQVICQWDGCNKSFSSAQELNDHLEAVHLTRGKSEYQCLWHDCHRTFPQRQKLIRHLKVHSKYKPYKCKTCKRCFSSEETLVQHTRTHSGEKPYKCHICNKKFAISSSLKIHIRTHTGEKPLQCKICGKRFNESSNLSKHIKTHQKKYKCSDCSKSFDDLGKLNSQKVKCALERKPYL", "length": 880 }, "evidence": [ { "id": "HGNC:7428", "url": "https://alliancegenome.org/gene/HGNC:7428#orthology", "database": "AGR" }, { "id": "MGI:101786", "url": "https://alliancegenome.org/gene/MGI:101786#orthology", "database": "AGR" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q07243-1", "protein_name": "Metal regulatory transcription factor 1", "gene_name": "Mtf1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGEHSPDDNIIFFKGEEDDLTPHDKMLRFVDDNGLVPSSSGTVYDRTTVLIEQDPGTLEDDEDDGQCGEPLPFLVEGEEGFLIDQEAMSQGYVQHIISPDQIHLTINPGSTPMPRNIEGATLTLQSECPETKRKEVKRYQCTFEGCPRTYSTAGNLRTHQKTHRGEYTFVCNQEGCGKAFLTSYSLRIHVRVHTKEKPFECDVQGCEKAFNTLYRLKAHQRLHTGKTFNCESQGCSKYFTTLSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFCPSNGCEKTFSTQYSLKSHMKGHDNKGTAYSALPQHNGSEDTNHSLYLSELGLLSTDSELQENSSSTQDQDLSTISPAIIFESMFQNSDDPGIQDDPLQTAALIDSFNGDAESVIDVPPPAGNSASLSLPLVLQSGISEPPQPLLPATAPSAPPPAPSLGPGSQPAAFGSPPALLQPPEVPVPHSTQFAANHQEFLPHPQAPPQTIVPGLSVVAGAPASAATVASAVAAPAPPQSTTEPLPAMVQTLPLGANSVLTNNPTITITPTPNTAILQSSLVMGEQNLQWILNGATSSPQNQEQIQQASKVEQVYFATAVPVASGTGSSVQQIGLSVPVIIIKQEEACQCQCACRDSAKERAAGRRKGCSSPPPPEPNPQPPDGPSLQLPP", "length": 675 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-020424-1", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-020424-1#orthology", "database": "AGR" }, { "id": "HGNC:7428", "url": "https://alliancegenome.org/gene/HGNC:7428#orthology", "database": "AGR" }, { "id": "MGI:101786", "url": "https://alliancegenome.org/gene/MGI:101786#orthology", "database": "AGR" }, { "id": "A0A0G2KFP7", "url": "https://omabrowser.org/oma/group/A0A0G2KFP7/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q08DF6-1", "protein_name": "Metal regulatory transcription factor 1", "gene_name": "MTF1", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MGDHSPDDSISYFEVEEDELTPDDKMLRFVDKNGLVPSSSGTVYDRTTVLIEQDPGTLEDEDDDGQCGEHLPFLVGGEEGFHLIDHEAMSQGYVQHIISPDQIHLTINPGSTPMPRNIEGATLTLQSECPETKRKEVKRYQCTFEGCPRTYSTAGNLRTHQKTHRGEYTFVCNQEGCGKAFLTSYSLRIHVRVHTKEKPFECDVQGCEKAFNTLYRLKAHQRLHTGKTFNCESEGCSKYFTTLSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFCPSNGCEKTFSTQYSLKSHMKGHDNKGNSYSALLNHNGSEDTNHSLCLRNLSLLSTDSEFQENSNTGQNLSTLSPAIIFGPMFQKSDDPAIQEDPQQTAALIESFNGDAESVSDVPPSTRHSASLSLPLILQPGISEPPQPLLPASAPSAPLPAPSLGTGSQQAAFGNPPALLQPPEVPVAHSTQFAANHQEFLPHLQAPQPIVPGLSVVAGALASAAAVASAMAAPPQPQSTTEPLPAMVQTLPLDANSVLTSNPTITITPTPSAAILQPSLVMGEQNLQWLLNGATSTPQAQEQIQQASKVEKVFFTTAVPVASSTGSAVQQIGLSVPVIIIKQEEACQCQCACRDSAKERAASRRKGCPSPPPPTLSAQPPDGPSLKLPPQTFSPPPIPLSSSSTAASSCEQSRQAVTPSDPQTEPLRAIDMSEFLSLQSLDTTSNLIPIEALLQEEEEMGLTSSFSK", "length": 751 }, "evidence": [ { "id": "A0A0G2KFP7", "url": "https://omabrowser.org/oma/group/A0A0G2KFP7/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "Q14872-1", "protein_name": "Metal regulatory transcription factor 1", "gene_name": "MTF1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGEHSPDNNIIYFEAEEDELTPDDKMLRFVDKNGLVPSSSGTVYDRTTVLIEQDPGTLEDEDDDGQCGEHLPFLVGGEEGFHLIDHEAMSQGYVQHIISPDQIHLTINPGSTPMPRNIEGATLTLQSECPETKRKEVKRYQCTFEGCPRTYSTAGNLRTHQKTHRGEYTFVCNQEGCGKAFLTSYSLRIHVRVHTKEKPFECDVQGCEKAFNTLYRLKAHQRLHTGKTFNCESEGCSKYFTTLSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFCPSNGCEKTFSTQYSLKSHMKGHDNKGHSYNALPQHNGSEDTNHSLCLSDLSLLSTDSELRENSSTTQGQDLSTISPAIIFESMFQNSDDTAIQEDPQQTASLTESFNGDAESVSDVPPSTGNSASLSLPLVLQPGLSEPPQPLLPASAPSAPPPAPSLGPGSQQAAFGNPPALLQPPEVPVPHSTQFAANHQEFLPHPQAPQPIVPGLSVVAGASASAAAVASAVAAPAPPQSTTEPLPAMVQTLPLGANSVLTNNPTITITPTPNTAILQSSLVMGEQNLQWILNGATSSPQNQEQIQQASKVEKVFFTTAVPVASSPGSSVQQIGLSVPVIIIKQEEACQCQCACRDSAKERASSRRKGCSSPPPPEPSPQAPDGPSLQLPAQTFSSAPVPGSSSSTLPSSCEQSRQAETPSDPQTETLSAMDVSEFLSLQSLDTPSNLIPIEALLQGEEEMGLTSSFSK", "length": 753 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-020424-1", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-020424-1#orthology", "database": "AGR" }, { "id": "HGNC:7428", "url": "https://alliancegenome.org/gene/HGNC:7428#orthology", "database": "AGR" }, { "id": "MGI:101786", "url": "https://alliancegenome.org/gene/MGI:101786#orthology", "database": "AGR" }, { "id": "A0A0G2KFP7", "url": "https://omabrowser.org/oma/group/A0A0G2KFP7/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KFP7", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KFP7" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KFP7", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KFP7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KFP7", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KFP7" } ], "pmid": "" }, { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KFP7", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KFP7" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KFP7", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KFP7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "response to zinc ion", "id": "GO:0010043", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010043", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KFP7", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KFP7" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KFP7", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KFP7" } ], "pmid": "" }, { "name": "central nervous system development", "id": "GO:0007417", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007417", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KFP7", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KFP7" } ], "pmid": "" }, { "name": "response to cadmium ion", "id": "GO:0046686", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046686", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KFP7", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KFP7" } ], "pmid": "" }, { "name": "cellular response to cadmium ion", "id": "GO:0071276", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071276", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KFP7", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KFP7" } ], "pmid": "" }, { "name": "cellular response to zinc ion", "id": "GO:0071294", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071294", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KFP7", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KFP7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 10, "end_pos": 12, "annotation": "n_glycosylation_sequon" }, { "start_pos": 369, "end_pos": 371, "annotation": "n_glycosylation_sequon" }, { "start_pos": 661, "end_pos": 663, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.agr", "label": "AGR Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 150 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 10, "end_pos": 12 }, { "start_pos": 369, "end_pos": 371 }, { "start_pos": 661, "end_pos": 663 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": 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{ "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 13 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }