{ "uniprot_canonical_ac": "A0A0G2KB00-1", "uniprot_ac": "A0A0G2KB00", "uniprot_id": "A0A0G2KB00_RAT", "mass": { "chemical_mass": 246852.0, "monoisotopic_mass": 246852.0 }, "refseq": {}, "gene_names": [ { "name": "Frem1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KB00", "id": "A0A0G2KB00" } ], "protein_names": [ { "name": "FRAS1-related extracellular matrix protein 1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KB00/entry#names_and_taxonomy", "id": "A0A0G2KB00" }, { "name": "Protein QBRICK", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KB00/entry#names_and_taxonomy", "id": "A0A0G2KB00" } ], "function": [ { "annotation": "Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development.", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KB00", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KB00#function" }, { "database": "UniProtKB", "id": "ARBA00058451", "url": "https://www.uniprot.org/uniprotkb/ARBA00058451#function" } ] } ], "disease": [ { "disease_id": "DOID:0060732", "recommended_name": { "id": "DOID:0060732", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060732", "name": "chromosome 9p deletion syndrome", "description": "A chromosomal deletion syndrome characterized by trigonocephaly, flattened occiput midface hypoplasia, long philtrum, prominent forehead, broad flat nasal bridge, anteverted nares, malformed external ears, hypertelorism, hypertonia, delayed psychomotor development and that has_material_basis_in a contiguous gene deletion on the short arm of chromosome 9." }, "synonyms": [ { "id": "DOID:0060732", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060732", "name": "9p syndrome", "description": "" }, { "id": "DOID:0060732", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060732", "name": "Alfi syndrome", "description": "" }, { "id": "DOID:0060732", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060732", "name": "monosomy 9p syndrome", "description": "" }, { "id": "MONDO:0008013", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008013", "name": "chromosome 9p deletion syndrome", "description": "Monosomy 9p is a rare chromosomal anomaly characterized by psychomotor developmental delay, facial dysmorphism (trigonocephaly, midface hypoplasia, upslanting palpebral fissures, dysplastic small ears, flat nasal bridge with anteverted nostrils and long philtrum, micrognathia, choanal atresia, short neck), single umbilical artery, omphalocele, inguinal or umbilical hernia, genital abnormalities (hypospadia, cryptorchidism), muscular hypotonia and scoliosis." }, { "id": "MONDO:0008013", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008013", "name": "9p deletion", "description": "" }, { "id": "MONDO:0008013", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008013", "name": "9p deletion syndrome", "description": "" }, { "id": "MONDO:0008013", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008013", "name": "9p monosomy", "description": "" }, { "id": "MONDO:0008013", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008013", "name": "9p syndrome", "description": "" }, { "id": "MONDO:0008013", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008013", "name": "9p- syndrome", "description": "" }, { "id": "MONDO:0008013", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008013", "name": "Alfi syndrome", "description": "" }, { "id": "MONDO:0008013", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008013", "name": "chromosome 9p deletion", "description": "" }, { "id": "MONDO:0008013", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008013", "name": "deletion 9p", "description": "" }, { "id": "MONDO:0008013", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008013", "name": "monosomy 9p", "description": "" }, { "id": "MONDO:0008013", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008013", "name": "monosomy 9p syndrome", "description": "" }, { "id": "MONDO:0008013", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008013", "name": "monosomy type 9p", "description": "" }, { "id": "MONDO:0008013", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008013", "name": "partial deletion of chromosome 9p", "description": "" }, { "id": "MONDO:0008013", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008013", "name": "partial deletion of the short arm of chromosome 9", "description": "" }, { "id": "MONDO:0008013", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008013", "name": "partial deletion of the short arm of chromosome type 9", "description": "" }, { "id": "MONDO:0008013", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008013", "name": "partial monosomy 9p", "description": "" }, { "id": "MONDO:0008013", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008013", "name": "partial monosomy of chromosome 9p", "description": "" }, { "id": "MONDO:0008013", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008013", "name": "partial monosomy of the short arm of chromosome 9", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "0060732", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0060732" } ] }, { "disease_id": "DOID:0090001", "recommended_name": { "id": "DOID:0090001", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0090001", "name": "Fraser syndrome", "description": "A syndrome characterized by cryptophthalmos, syndactyly, ambiguous genitalia, laryngeal and genitourinary malformations, oral clefting, and mental retardation that has_material_basis_in homozygous or compound heterozygous mutation in the FRAS1 gene on chromosome 4q21, the FREM2 gene on chromosome 13q13, or the GRIP1 gene on chromosome 12q14." }, "synonyms": [ { "id": "DOID:0090001", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0090001", "name": "cryptophthalmos with other malformations", "description": "" }, { "id": "MONDO:0054737", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0054737", "name": "Fraser syndrome 1", "description": "" }, { "id": "MONDO:0054737", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0054737", "name": "Fraser syndrome 1", "description": "" }, { "id": "MONDO:0054737", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0054737", "name": "FRASRS1", "description": "" }, { "id": "MONDO:0054737", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0054737", "name": "Fraser syndrome", "description": "" }, { "id": "MONDO:0054737", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0054737", "name": "cryptophthalmos with Other malformations", "description": "" }, { "id": "MONDO:0054737", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0054737", "name": "cryptophthalmos-syndactyly syndrome", "description": "" }, { "id": "MIM:219000", "resource": "MIM", "url": "https://www.omim.org/entry/219000", "name": "Fraser syndrome 1", "description": "Fraser syndrome 1" } ], "unlinked_id_list": [], "evidence": [ { "id": "0090001", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0090001" } ] }, { "disease_id": "DOID:3827", "recommended_name": { "id": "DOID:3827", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3827", "name": "congenital diaphragmatic hernia", "description": "A diaphragm disease characterized by the lack of development of all or part of the diaphragm, which results in an abnormal opening that allows the stomach and intestines to move into the chest cavity and crowd the heart and lungs." }, "synonyms": [ { "id": "DOID:3827", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3827", "name": "Diaphragmatic Hernia", "description": "" }, { "id": "MONDO:0007719", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007719", "name": "diaphragmatic hernia 1", "description": "" }, { "id": "MONDO:0007719", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007719", "name": "diaphragmatic hernia, congenital 1", "description": "" }, { "id": "MONDO:0007719", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007719", "name": "hernia, congenital diaphragmatic 1", "description": "" }, { "id": "MONDO:0007719", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007719", "name": "DIH1", "description": "" }, { "id": "MONDO:0007719", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007719", "name": "diaphragm, complete agenesis of", "description": "" }, { "id": "MONDO:0007719", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007719", "name": "diaphragm, unilateral agenesis of", "description": "" }, { "id": "MONDO:0007719", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007719", "name": "diaphragmatic defect, congenital", "description": "" }, { "id": "MONDO:0007719", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007719", "name": "diaphragmatic hernia, congenital", "description": "" }, { "id": "MONDO:0007719", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007719", "name": "hemidiaphragm, agenesis of", "description": "" }, { "id": "MONDO:0007719", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007719", "name": "hernia, congenital diaphragmatic", "description": "" }, { "id": "MONDO:0009103", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009103", "name": "diaphragmatic hernia 2", "description": "" }, { "id": "MONDO:0009103", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009103", "name": "diaphragmatic hernia 2", "description": "" }, { "id": "MONDO:0009103", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009103", "name": "hernia, congenital diaphragmatic 2", "description": "" }, { "id": "MONDO:0009103", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009103", "name": "DIH2", "description": "" }, { "id": "MONDO:0012431", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012431", "name": "diaphragmatic hernia 3", "description": "Any congenital diaphragmatic hernia in which the cause of the disease is a mutation in the ZFPM2 gene." }, { "id": "MONDO:0012431", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012431", "name": "ZFPM2 congenital diaphragmatic hernia", "description": "" }, { "id": "MONDO:0012431", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012431", "name": "congenital diaphragmatic hernia caused by mutation in ZFPM2", "description": "" }, { "id": "MONDO:0012431", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012431", "name": "diaphragmatic hernia 3", "description": "" }, { "id": "MONDO:0012431", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012431", "name": "diaphragmatic hernia type 3", "description": "" }, { "id": "MONDO:0012431", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012431", "name": "DIH3", "description": "" }, { "id": "MIM:610187", "resource": "MIM", "url": "https://www.omim.org/entry/610187", "name": "Diaphragmatic hernia 3", "description": "Diaphragmatic hernia 3" } ], "unlinked_id_list": [], "evidence": [ { "id": "3827", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3827" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KB00", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KB00" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "gene": [ { "name": "Frem1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KB00", "locus": { "chromosome": "5", "start_pos": 97322538, "end_pos": 97469543, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000022309", "url": "https://www.ensembl.org/id/ENSRNOG00000022309" } ] } } ], "crossref": [ { "id": "RGD:1306981", "url": "https://alliancegenome.org/gene/RGD:1306981", "database": "AGR", "categories": [ "Protein Classification" ] }, { "id": "ENSRNOG00000022309", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000022309", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00037", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00037", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001304", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001304", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003644", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003644", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016186", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016186", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016187", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016187", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038081", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038081", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039005", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039005", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045658", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045658", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051561", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051561", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "DIGPHLQ", "url": "https://omabrowser.org/oma/group/DIGPHLQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR45739", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45739", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45739:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45739:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00059", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00059", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF03160", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03160", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF16184", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16184", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF19309", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF19309", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "NP_001178686", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178686", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1306981", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1306981", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A0G2KB00", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KB00", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2KB00-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KB00-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHSPGCTGPKALLFLLLQLLMLHLDPANATFISINRGLRVMKGSSAFLSGDHLRFAIPKEKDACRVEVVMNEPITQRVGKLIPQVFDCHFLPNEVQYVHNGCPILDEDSVKLRLYRFTETETFMETFLLRVSLVEPDCNIIRLSSNVLEVTEFYGLSQAIDKNLLQFDYDRTASLDCTIRVDPVKTQLPAHGKLVVVNRKSEGPRGDQPHSFFSESQLGAERKCPDGSCTLEPKQVTSLKVSCEDFLLTGFHYQHMQPPSPNIDYIPIQLDLTDRRSKTIYKSESAWLPVFIRVGIPNQAPRAAFMAMFVLEVDQFILTPLTTSVLDCEEDETPKPLLVFNITEAPLQGYVTHLLDHTRPISSFTWKDLSDMQVAYQPPNNSHPERRHYKMELEVYDLFFERSAPITVHISIRTADTNAPRVSWNTGLNLLEGQSRAITWEQFQIVDNDDIGAVQLVTIGGLQHGRLTVREGKGFLFTVADLQAGVVRYHHDDSDTTKDFVAFRIFDGQHSSHHKFPINILPKDDSPPFLITNVVIELEEGKTILIQGSMLRASDMDSSDDYIFFNITKFPQAGEIMKKPGPRLIGYPVSGFLQRDLFSGIIYYRHFGGEIFEDSFEFVLWDSHEPPNLSVPQVVMVHITPVDDQLPKEAPGISRHLIVKETEVAYITKKHLHFLDTESHGGELVYTITRPPCFSSSHRHLDAGKLFMVDSIPKPTKNPTAPGLNSFTQVKRFGKTLANTVSTLLGGLGLGCSNIVISVNQCICASQFASQHAVNHMKVAYMPPMQDIGPTPRHVQFTVSVSNQHGGTLHGICFNITVLPVDNQVPEVFTNTLRVAEGGQCTISTEHILVSDVDTPLDSICLSLQEMPLHGGVELDGFPLNPRGTFSWRDLHTLKVRYQHDGSEVLQDEIFLEVTDGTNSAGFVLYIEVFPVNDEPPVLKADLIPMMHCSEGGEVTITPEYIFATDADSNDSELLFLITREPRHGVVRKAGLRVDRFSQGDVISGAVAYKHTGGEIGLESCFDTVVLVVSDGEADPLVNGCCYNGPDSSVPLHKSFPTYQLNITVHPVDNQPPSIIIGRTLTVDEGFSAALTTHHLTATDWDTAPDDLEFILVSHPQFGYLENTLPSAGFEKRNTGISIASFQWRDMKASHINYVQSRHLREEPTADEFLVYATDGKQRSLETTFHVIINPTNDEAPDFVVQNITVYEGHMVELDSAIISATDRDVPKDPLLFNITHKPKHGLLLISATSKDAHNEIHNFSMELLQNGMKLAYAHDDSESSADNFVIQLSDGKHKILKTVSVSITPVNDETPTLSKKAEVSVTVGDTRVLSSAVLSAIDKDSPREKIHYLFERLPQNGQLQLKIGRDWVPLSAGMQCTQEDVDLNLLRYAHAGKMHSQDGDRFTFYLWDGDNRSPAFDCHIIIEDTGRGDIVIHAKPLVVANGDRGLLTPATLLAEDGADKAEELLYLITSPPQYGQVEYVYSPGVPITSFSQMDIAGQAVCYIHKSRTAVLSDSFRFTISNGLQTQQGVFEITLQGVDSALPVLTRNRRLRLVEGAMGLLSTDHLQLTDPDTPPENLTFFLVQLPRHGYLYLRGKVLQHNFTQQDVDSRVVAYQHAGGGAQEDCFTFLATDRKNQGFVVDGKVQKEPVLFIIQVDQLDKKAPRITRLHSPSQVGLLKNGCYGIYITSHVLKASDPDTEDDQIIFKILRGPLHGRLENTTTGEFIHEQFSQKDLSRKTILYIINPSLQVNSDILEFQAMDPTGNTAPPQRLELKWSYIEWSQTEYEVCENVGLLTLEVTRRGYSMDSAYVDIEVNQVSAVVGKDFTVTPSKLLQFDPGMSTKMWNIAITYDGLEEDDEVFEVILNSPVNAVLGTQTKAAVKILDSKGGRCHPSNSFNQSKHSTWGKGRWHPLPSGSSSLTTSGSPHLERRPPPSITKGDALRGFDLTDLSQRKMTTQGNGKSVLPSSVCRNGTDTIYNYHGIVSLKLEGDRFSAHKRKAKISVIRQPQRTVKVAELPLADKVEPTTDSNFLSQGLRPLFPKNCSVELKGLFHLEEHTHRLYQCDGIAWNVWSSQTKGLEDRSCPVGWLLHSDYCHVLVTRQKGTWATATRACREQHQGTLVTVFSRRHMQWLWAISGRKPFWIGLKNQVRTGHWEWIGGEPVAFTNWRRGPPLHPKPGKNCVLVQRRGQWQTKNCSKGKAHNFVCSRKL", "length": 2209, "header": "tr|A0A0G2KB00-1|A0A0G2KB00_RAT Isoform 1 of FRAS1-related extracellular matrix protein 1 OS=Rattus norvegicus OX=10116 GN=Frem1 PE=3 SV=2 CANONICAL=A0A0G2KB00-1" }, "isoforms": [ { "isoform_ac": "A0A0G2KB00-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KB00/entry#A0A0G2KB00-1", "sequence": { "sequence": "MHSPGCTGPKALLFLLLQLLMLHLDPANATFISINRGLRVMKGSSAFLSGDHLRFAIPKEKDACRVEVVMNEPITQRVGKLIPQVFDCHFLPNEVQYVHNGCPILDEDSVKLRLYRFTETETFMETFLLRVSLVEPDCNIIRLSSNVLEVTEFYGLSQAIDKNLLQFDYDRTASLDCTIRVDPVKTQLPAHGKLVVVNRKSEGPRGDQPHSFFSESQLGAERKCPDGSCTLEPKQVTSLKVSCEDFLLTGFHYQHMQPPSPNIDYIPIQLDLTDRRSKTIYKSESAWLPVFIRVGIPNQAPRAAFMAMFVLEVDQFILTPLTTSVLDCEEDETPKPLLVFNITEAPLQGYVTHLLDHTRPISSFTWKDLSDMQVAYQPPNNSHPERRHYKMELEVYDLFFERSAPITVHISIRTADTNAPRVSWNTGLNLLEGQSRAITWEQFQIVDNDDIGAVQLVTIGGLQHGRLTVREGKGFLFTVADLQAGVVRYHHDDSDTTKDFVAFRIFDGQHSSHHKFPINILPKDDSPPFLITNVVIELEEGKTILIQGSMLRASDMDSSDDYIFFNITKFPQAGEIMKKPGPRLIGYPVSGFLQRDLFSGIIYYRHFGGEIFEDSFEFVLWDSHEPPNLSVPQVVMVHITPVDDQLPKEAPGISRHLIVKETEVAYITKKHLHFLDTESHGGELVYTITRPPCFSSSHRHLDAGKLFMVDSIPKPTKNPTAPGLNSFTQVKRFGKTLANTVSTLLGGLGLGCSNIVISVNQCICASQFASQHAVNHMKVAYMPPMQDIGPTPRHVQFTVSVSNQHGGTLHGICFNITVLPVDNQVPEVFTNTLRVAEGGQCTISTEHILVSDVDTPLDSICLSLQEMPLHGGVELDGFPLNPRGTFSWRDLHTLKVRYQHDGSEVLQDEIFLEVTDGTNSAGFVLYIEVFPVNDEPPVLKADLIPMMHCSEGGEVTITPEYIFATDADSNDSELLFLITREPRHGVVRKAGLRVDRFSQGDVISGAVAYKHTGGEIGLESCFDTVVLVVSDGEADPLVNGCCYNGPDSSVPLHKSFPTYQLNITVHPVDNQPPSIIIGRTLTVDEGFSAALTTHHLTATDWDTAPDDLEFILVSHPQFGYLENTLPSAGFEKRNTGISIASFQWRDMKASHINYVQSRHLREEPTADEFLVYATDGKQRSLETTFHVIINPTNDEAPDFVVQNITVYEGHMVELDSAIISATDRDVPKDPLLFNITHKPKHGLLLISATSKDAHNEIHNFSMELLQNGMKLAYAHDDSESSADNFVIQLSDGKHKILKTVSVSITPVNDETPTLSKKAEVSVTVGDTRVLSSAVLSAIDKDSPREKIHYLFERLPQNGQLQLKIGRDWVPLSAGMQCTQEDVDLNLLRYAHAGKMHSQDGDRFTFYLWDGDNRSPAFDCHIIIEDTGRGDIVIHAKPLVVANGDRGLLTPATLLAEDGADKAEELLYLITSPPQYGQVEYVYSPGVPITSFSQMDIAGQAVCYIHKSRTAVLSDSFRFTISNGLQTQQGVFEITLQGVDSALPVLTRNRRLRLVEGAMGLLSTDHLQLTDPDTPPENLTFFLVQLPRHGYLYLRGKVLQHNFTQQDVDSRVVAYQHAGGGAQEDCFTFLATDRKNQGFVVDGKVQKEPVLFIIQVDQLDKKAPRITRLHSPSQVGLLKNGCYGIYITSHVLKASDPDTEDDQIIFKILRGPLHGRLENTTTGEFIHEQFSQKDLSRKTILYIINPSLQVNSDILEFQAMDPTGNTAPPQRLELKWSYIEWSQTEYEVCENVGLLTLEVTRRGYSMDSAYVDIEVNQVSAVVGKDFTVTPSKLLQFDPGMSTKMWNIAITYDGLEEDDEVFEVILNSPVNAVLGTQTKAAVKILDSKGGRCHPSNSFNQSKHSTWGKGRWHPLPSGSSSLTTSGSPHLERRPPPSITKGDALRGFDLTDLSQRKMTTQGNGKSVLPSSVCRNGTDTIYNYHGIVSLKLEGDRFSAHKRKAKISVIRQPQRTVKVAELPLADKVEPTTDSNFLSQGLRPLFPKNCSVELKGLFHLEEHTHRLYQCDGIAWNVWSSQTKGLEDRSCPVGWLLHSDYCHVLVTRQKGTWATATRACREQHQGTLVTVFSRRHMQWLWAISGRKPFWIGLKNQVRTGHWEWIGGEPVAFTNWRRGPPLHPKPGKNCVLVQRRGQWQTKNCSKGKAHNFVCSRKL", "length": 2209, "header": "tr|A0A0G2KB00-1|A0A0G2KB00_RAT Isoform 1 of FRAS1-related extracellular matrix protein 1 OS=Rattus norvegicus OX=10116 GN=Frem1 PE=3 SV=2 CANONICAL=A0A0G2KB00-1" }, "locus": { "chromosome": "5", "start_pos": 97441295, "end_pos": 97323717, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000078862.2", "url": "https://www.ensembl.org/id/ENSRNOT00000078862.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000075592.2", "url": "https://www.ensembl.org/id/ENSRNOP00000075592.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "start_pos": 791, "start_aa": "Thr", "end_pos": 791, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr791", "evidence": [ { "id": "GLY_001157", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001157" } ], "filter_code": "00000000000000001000.00000000001000.0.xxxxx" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A8V0YPJ1-1", "protein_name": "FRAS1-related extracellular matrix protein 1", "gene_name": "FREM1", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MKPFEKTWLLLLLPVLLRVVCSSFVSVNLGIKVMKGQSVFLSEDDLKFSIPREKDVCKVEVVRNEPITQRVGKLTPQVFDCHFHLNEVKYTHNGCPILDADTVMLRLYRFTENETFVETFTLHVQLLEPDCNIIKMRSRALEVAEYYGLSRAIDKNSLTFDYSRKMNLECTISIASSETHLPAHGQLIMGDTRQEKLRGDQPQSFLLGPKHSPGQQCRNGSCVLGLRVIHNTKMSCEEFLRKGIRYQHLDPRSPDIDYIPVRLDLTDSRSKTLHKTEYAWLPVRIKSAMPNQIPKAVPMTKFILEVDQFILTPITTTTVDAEDKETPKSLLVFNITKPPLQGFITHLSDHTKPVGSFTWKDLSEMLIAYQPPNNSHTERRNYELEVEVHDFYFERSLPTIVQLSIRTADTNAPRVSWNTGLSLLEGQSRPITWQHLQVVDNDDIQNVRLVTVDGLQHGRLTVRGGKGFMFTVSDIQTGVVRYHHDDSDSTKDFVVFRIFDGLHSIRHKFPINILPKDDSPPFLISNVVIEVQEGQTILIQGSMLQASDMDSSDDYIVFNITKPPQAGEIMKKPGPNLIGYPVSSFLQRDLFNGIMYYHHLGGEVFEDSIEFVLCDSHDPPNLSEPQVMTVHIAPVDDQLPKEAPGVTRHLVVKETEIAHLTKKHLHFIDVEEQDRELTYTITTSPFFSCVHGHSDAGKLFMVDTIPKLVKDPAALALRSFTQHAVNYLKVAYMPPLQDIGPNPQHVQFVFSVSNQHGGTLYGICFNITILPVDNQAPEVLTSHLRVEEGGLSPVTEGHILVSDVDTKQEHLLLLLQRQPQHGAVELDGVPMKEGDKLSCADLRTLAVSYRHDGSETLTDEVLFVATDGIHSLEFTLQVKVLPMNDEPPVVQTGLINVLSCPEGEEVVLSSEYIYATDADSDDMKLVFVLVRQPSQGVLRRAGIAVERFSQADVISGLVTYKHTGGEIGLTLTFETLTFVVSDDEAGPDVKDCCYDRLLPPPVPPHRPLPVYDLNITVLPVDNQPPSIAIGARFVVEEGSSAALTSNHLFATDPDTPADDLEFVLVSPPQFGYIENILPSPGFEKSNVGISIASFQLKHLKALNINYVQARHMRMEPRADHFVLYVTDGLHRSAEIPFFVLINPTNDEVPEFIARNITVQEGMMKELDLSVISAVDLDVPQDHLVFGVVQQPSHGFLINGVHGNDILHYKELIQHHNHGLLVHDFSMELLQNGMKLMYMHDDSESLSDSFKIQLSDGKHKVLRTISVKVIPVNDEKPVLSKKDNIEVHMGETRIISSAVLSAEDKDTPRERIYYLFERLPESGQLQLKVGRDWVTLQTGMKCTQEELDMNLVRYVHTGAIGSKNQDLFTFYLWDGYNRSPAVDFYINIKDMEKGDIAVFIKPLKVSKGDRGYITTDVLLSLDGTDKPEELLYVITSPPQYGQIEYASYPDIPITSFSQMDVASQIVCYVHNTKAHSRQDAFRFIISNGLRTKHGTFMISLEAVDQTLPTLSRNRGLRLVEGNMVLLSPDVLQLTDSDTAKENLTFILAQLPQYGHLYYRGAVLLQYSFTQRDVDNMDVAYKHRGGDSRVDKFTFVATDRTNQGFIVNGRVQIEPVAFTIQVDHLDKMAPKIIHLRCLSDVEMLKNGNYGIYITSRSLKATDPNTEDDKIFFKILQGPRYGYLENITTGGLIHEGFSQKDLNSKIIFYVINPLWEVHSDNLEFQVTDTNGNSAIPQMLELRWSRIEMQQTEYEVCENVGTVSLKITRAGHSADSAFIAVKVNEISAVLGKDFTVTPSKLIQFDPGMSTKMWNIAITYDRLEEDDEVFEVVLNSSVNAVLGTKTKAVVKILDSKGGQCSTLHSSSQSKQDFWRRGTLFAVSSGSSSPPRPGNVHLEGISPPPSKRMREHRGDTLQDRRLAYQSRAKLRVTGNGRIVHPSSIFRNGTDVVYKYHGIVSLKIEDDTSSAKANKKAEVSVINQAQPQINAISTRKTEIPQADKAELASEASSRRQDFHSFSRACTPDLKGLMHYEESTQKLFQCDGIEWKFWSSQSKEASMKKCPSGWRHHDGSCYFLVVNQKVTWDTAAQACREQYLGSLTSVANEQHMQWLWDLGGRKPFWIGLNDQVNPGHWEWNGGEPVTYINWRRGSYRFTKRGNNCVVVQKRGKWQATDCRKAKWNSYICSRKL", "length": 2184 }, "evidence": [ { "id": "A0A0G2KB00", "url": "https://omabrowser.org/oma/group/A0A0G2KB00/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "B6IDE5-1", "protein_name": "Frem1b", "gene_name": "frem1b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGVFFLALTVLTSSHLWSHVQASSLVQLNRVIRVARGQSVFITANELQFHMDHKSEACKVEVVLNEPITQRVGKLTPQVFDCQFFPDEVKYVHNGSPLLEEDTVMLRVYRFTDTETFVESMLLKVRVFEPQRSLVELGNVPLVVPEFYGLSNAINASVLTFKTQPDVICTLRLLSSEISVPALGQLVVEESGTMVDTEAGPRKVFFCQFFFGRHTAIACPGNKACDLKTRQVEFLKTDCSEFLSSGLKYQHLSPPSPEIDYIPVRLEFRDQTSRALLETESVWLPVLIQGAMQNQPPHAAFMSTFILEVDQFILTPLSTAALDAKDDETPQDQLIFSVTKPPAEGYITHLDDHTKMASSFSWQDLNEMKIAYQPPNSSHTARRNYEVEFQAIDGSFAPSLPILMHISIRTAETNAPRVSWNMGLDLLEGQSRPITWEHLQIVDKDNIDAVTLIAMDGPLNGHLSVRGGKGFMFKVKDLREGVVVYHHSDSDTTRDYVVFRITDGRHSIRHKFPIYILPKDDTPPFLINNVAFEVQEGGTVRVEEYMLMASDLDSSDDYIQYQLITFPRAGQLIKKSSPHEPGLPVKSFLQRDLFQGLIYYKHSGEEVFEDSFDFILSDVHQPPNLSDRHTVVIHVFPVKDQLPVEVSGTVRSITVKETEVVYITQSLLHFRDTEHPDTDLMYVITHPCFSPGNTRLSDAGRLFYTDSTNAMKKDAMVPVLKSFTQHFINVQYHFAASSVSSLFCCPQHAVNHHKVAYMPPIEDIGPEPLFVQFVFSVSDHQGGALTGLTFNITVTPVDNQAPEMFTNLLRVEEGGGSFLMEEHLLVQDVDSSEDQLRIHMKTKPQHGRLELQGTAMLEGDSFTLRDLKALRVRYIHDDSETQKDSIGLTITDGINSAHGALLIQILPVNDEPPQLGSDLKAKLSCKEGGQVQITVEYLSATDVDSDDTRLTYMLARTPGRGVIQRNGVTVDKFSQLDVLNGLIFYLHTGGEIGPDPVSDTVTLIVSDGEAGTMDGCCQEDALPPPVPLHGTLPVYDLNITVMPVNNQVPTITLGGMIVVDEGARACLCGGVLEASDPDSRPEELMFHLVTPPQYGFLENTLPSPGFEKSNAGLRVVFFSQLHLSSGFINYVQSVHQGVEPTADFFTISVSDGMQRSAPLHVYIIINPTNDEVPSLLLSNFTVMEGGMKDLSPDILNAVDVDIPAESLTLTILDPPAHGTLINGIYGLEMNRYKSMNPEVLQQTLAIQSFTLEELQQGMKIMYMHDDTETLKDAFTIQLTDGGHTVQGTACVRIIPVNDEKPWLLKNAGVEVEALEKRVISSVVLEAGDQDTPSDHLLYILNAGPRFGLLQLRVKAGWVDLSPGQNFTQEDVEMNRLWYSHTTVSGFKGHDRFHFVLTDGENTTPPQSFFISVRTVQKGDIALITKPVTLLEGERVILTTDILTAADSGGRPDELIYTVAVPPEHGHLHMVQTPGVPVFSFSQMDVAANRVCYTHDNSRFADRDSFSFAISNGVASRSGTVHFTIEHSDRIPPTLSTNKGLELTEGSMKTISTEELKLTDPDTALENLTYVVTQSPQYGKLLFKGLPLSKPRFTQLDINNMDLAYQHLNGRATIDRFAFQPTDGTNKGYLEYGQLKSDPAVFTIQIEILDKTPPSIINKGIPSTVENLPDGKHGIYITSKELQASDPDSPDDTLEFTITRPPHFGFLENTLTGAFIKGRFTQKDVDQKAVRYVIPVDVEVTADSFEFQVTDPAGNTILPEVLELRWSRVDLSASCYRVCETAGTLAVQVLRSGNSKDPAYIGIQVEEGTAKVGKDFTHSSASLIQFDPGVNVKMWNIYLKDDGLEENHERFDIILKAPKNAVLGQRNKASVEIVDPRNGRCNPDDLIVEEDENQHTYQIQPHIPEPETPVLEEYTPDPRSGILWENYPPRGDVPYRTDFNHYSLTGQHMEQEAFHSPGRRQLRVLEGNRQRAGLSEVDSRNQERVWRFHGVIPVSQQEAAPRVHSELEITPIWSWPGDSAETPQRDSASDIQQHKSQTSVSIDCPNGWTHYRRNCYILGPGTASWSSAQHACTLLEGQLTGIHSKNDMKWIWKFAGKQPFWIGLVGGPEHGWIWTDGKVLSFSRLRKDEEDQTRSVCVLAQSQKMWIPKGCIDGSEHRYVCSAPAQIS", "length": 2167 }, "evidence": [ { "id": "HGNC:23399", "url": "https://alliancegenome.org/gene/HGNC:23399#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "E1BN52-1", "protein_name": "FRAS1-related extracellular matrix protein 1", "gene_name": "FREM1", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MSSPSWGGLGALLLLLLLPGWASPTFVRVNQGVRVMKGSSAFLSQDDLKFTIPKEKDACKVEVVMNEPITQRVGKLTPQVFDCHFLPNEVKYTHNGCPILDEDTVKLRLYRFTETDTFTETFILRVYLLEPDCNIIRMSDNALEVSEFYGLSRVIDKNLLRFDYERMASLECTVRLDPVGTHLPAHGQLVLVEPQLEEPRGDQPHSFFPESQLGTELKCPGGRCTLGLKKVGSLKVSCEEFLLMGLRYQHLGSPSPNIDYFSIQLDLTDSRSKISYKSESAWLPVYIRPGIPNQIPRAAFMAMFILEVDQFILTSLTTSVLDCEEDETPKPLLVFNITKAPLQGYVTHLWDHTRPVSSFTWKDLRDMQIAYQPPNSSHSERRLYEVELEVYDFFFEKSAPITVHISIRTTDTNAPRVSWNTGLNLLEGQSRAITWEQFQIVDNDDIHAVQVVTVDGLQHGRLTVRGGKGFLFTVADLQAGVVRYHHDDSDSTKDFVVFRIFDSQHSIQHKFPINILPKDDSPPFLITNVVIELEEGQTILIQGSMLRASDMDSSDDYIFFNITKPPQAGEIMKKPAPGLIGYPVPGFIQRDLFNGIIYYRHFGGEIFEDSFEFVLWDSHEPPNLSVPQVVTIHVTPVNDQLPKEAPGVSRHLVVKETEVAYITKKHLHFIDTESQDRELLYTITTPPFFSSSRRHLDAGKLFMVDSIPRLTKTPAAPGLKYFTQHAVNHMKVAYMPPMQDVGPHPRHVQFAFSVSNQHGGTLYGICFNITILPVDNQAPKVFTKPLRVAEGGQCVISTQHVLVSDEDTKLDNIYLSLQSPPQHGMVELNGFPLNKGTTFPWGVLQALKLRYQHDGSEELQDDIVLQVTDGTNTAEYVLHVEVFPVNDEPPVLKADLIPMMHCSEGEEVVITSEYIFATDVDSDDLKLIFMIVGEPQHGTVRRAGVTVHQFSQEDVVAGAVTYKHTGGEIGLMPCFDTITLVVSDREAGPFVNGCCYNGPHPSVPLHESFPMYDLNITVYPVDNQPPSVAIGTTFVVDEGFSAALTVNHLSATDPDTAADDLEFVLVSPPQFGYLENTLPSAGFEKSNMGISIASFQWKDMKALHINYVQSRHLGMEPTADKFVLYVTDGKRRSMEIPFYIIINATNDEAPDFIVQNITVCEGQMRELDSSIISATDRDIPKNPLLFSITHKPRHGLLINRAFSRNFFQYKQLANPGQKHELVYNFSMELLKNGMRLVYVHDDSESLADDFTIQVSDGKHKILKTIFVEVTPVNDEKPMLSKKAEITINMGETRIISSAVLSAIDEDSPREKIYYIFERIPQNGQLQLKIGRDWVPLYPGMKCTQEEVDLNLLRYTHTGAMDSKNQDSFTFRLWDGDNRSPAFDCHITIKNMGKGDIVILAKPLVVSKGDRGFLTTTTLLAVDGTDKPEELLYVITSPPQFGQVEYVRYPGVPITSFSQMDIAGQTVCYVDKSTTAVHRDTFRFIVSNGLQTKPGVFEITLETVDTALPVVTRNKGLRLVEGATGLLSPDLLQLTDPDTPAEKLTFLLAQLPRHGQLYLRGMALIPHNFTQLDVDSGHVAYRHLGGDSWTDHFTFVATDGTNHGFLVDGRVWQEPVSFTIQVDQLDKAAPRVTHLHSPSQVGLLKNGCYGIYITSRVLKASDPDTDDNQIIFKILRGPQHGHLENSTTGEFIHEKFSQKDLNSKTVLYIINPSLEVNSDTMEFQVMDPTGNSATPQSLELNWSYIEWSRTEYEVCENMGMLPLEITRRGYSMDSAFVTVQVNQVSATVGKDFTMTPSKLVQFDPGMSTKMWNIAITYDGLEEDDEVFEVILNSPVNAVLGTKTKTAVKILDSKGGQCHPSNAFNSNMPSAWEKGIWHLLSPGASSPTTSDSFHLERRPLPTSKQLAVTRGDALRDFGSEDLSPVKLRTRGDGKTVPPSSVYKNRTDIIYNYHGVISLKLEDDGSPARRRKANVSFISEPQKTTKVAEPPQADKEESTTGSHFPRQDPLPSFPKNCTPELKGLFHFEESLQKLYKCDGIAWRSWSPHTKEVEDKSCPAGWHHHSGYCHSLITEQKGTWTTAAQACREHYQGSLVTVISRQHMRWLWDISGRKPFWIGLNDQVRAGHWEWIGGEPVTFTNWRRGPPQRSRHGKDCVLVQRPGKWHTKDCRKGKSHSYVCSRKL", "length": 2180 }, "evidence": [ { "id": "A0A0G2KB00", "url": "https://omabrowser.org/oma/group/A0A0G2KB00/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "Q5H8C1-1", "protein_name": "FRAS1-related extracellular matrix protein 1", "gene_name": "FREM1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNSLSWGAANAVLLLLLLAWASPTFISINRGVRVMKGHSAFLSGDDLKFAIPKEKDACKVEVVMNEPITQRVGKLTPQVFDCHFLPNEVKYVHNGCPILDEDTVKLRLYRFTERDTFIETFILWVYLLEPDCNIIHMSNNVLEVPEFNGLSQAIDKNLLRFDYDRMASLECTVSLDTARTRLPAHGQMVLGEPRPEEPRGDQPHSFFPESQLRAKLKCPGGSCTPGLKKIGSLKVSCEEFLLMGLRYQHLDPPSPNIDYISIQLDLTDTRSKIVYKSESAWLPVYIRAGIPNQIPKAAFMAVFILEVDQFILTSLTTSVLDCEEDETPKPLLVFNITKAPLQGYVTHLLDHTRPISSFTWKDLSDMQIAYQPPNSSHSERRHDEVELEVYDFFFERSAPMTVHISIRTADTNAPRVSWNTGLSLLEGQSRAITWEQFQVVDNDDIGAVRLVTVGGLQHGWLTLRGGKGFLFTVADLQAGVVRYHHDDSDSTKDFVVFRIFDGHHSIRHKFPINVLPKDDSPPFLITNVVIELEEGQTILIQGSMLRASDVDASDDYIFFNITKPPQAGEIMKKPGPGLIGYPVHGFLQRDLFNGIIYYRHFGGEIFEDSFQFVLWDSHEPPNLSVPQVATIHITPVDDQLPKEAPGVSRHLVVKETEVAYITKKQLHFIDSESYDRELVYTITTPPFFSFSHRHLDAGKLFMVDSIPKVVKNPTALELRSFTQHAVNYMKVAYMPPMQDIGPHCRDVQFTFSVSNQHGGTLHGICFNITILPVDNQVPEAFTNPLKVTEGGQSIISTEHILISDADTKLDNIDLSLRELPLHGRVELNGFPLNSGGTFSWGDLHTLKVRYQHDGTEVLQDDLLLEVTDGTNSAEFVLHVEVFPVNDEPPVLKADLMPVMNCSEGGEVVITSEYIFATDVDSDNLKLMFVIAREPQHGVVRRAGVTVDQFSQRDVISEAVTYKHTGGEIGLMPCFDTITLVVSDGEAGPFVNGCCYNGPNPSVPLHASFPVYDLNITVYPVDNQPPSIAIGPVFVVDEGCSTALTVNHLSATDPDTAADDLEFVLVSPPQFGYLENILPSVGFEKSNIGISIDSFQWKDMNAFHINYVQSRHLRIEPTADQFTVYVTDGKHHSLEIPFSIIINPTNDEAPDFVVQNITVCEGQMKELDSSIISAVDLDIPQDALLFSITQKPRHGLLIDRGFSKDFSENKQPANPHQKHAPVHSFSMELLKTGMRLTYMHDDSESLADDFTIQLSDGKHKILKTISVEVIPVNDEKPMLSKKAEIAMNMGETRIISSAILSAIDEDSPREKIYYVFERLPQNGQLQLKIGRDWVPLSPGMKCTQEEVDLNLLRYTHTGAMDSQNQDSFTFYLWDGNNRSPALDCQITIKDMEKGDIVILTKPLVVSKGDRGFLTTTTLLAVDGTDKPEELLYVITSPPRYGQIEYVHYPGVPITNFSQMDVVGQTVCYVHKSKVTVSSDRFRFIISNGLRTEHGVFEITLETVDRALPVVTRNKGLRLAQGAVGLLSPDLLQLTDPDTPAENLTFLLVQLPQHGQLYLWGTGLLQHNFTQQDVDSKNVAYRHSGGDSQTDCFTFMATDGTNQGFIVNGRVWEEPVLFTIQVDQLDKTAPRITLLHSPSQVGLLKNGCYGIYITSRVLKASDPDTEDDQIIFKILQGPKHGHLENTTTGEFIHEKFSQKDLNSKTILYIINPSLEVNSDTVEFQIMDPTGNSATPQILELKWSHIEWSQTEYEVCENVGLLPLEIIRRGYSMDSAFVGIKVNQVSAAVGKDFTVIPSKLIQFDPGMSTKMWNIAITYDGLEEDDEVFEVILNSPVNAVLGTKTKAAVKILDSKGGQCHPSYSSNQSKHSTWEKGIWHLLPPGSSSSTTSGSFHLERRPLPSSMQLAVIRGDTLRGFDSTDLSQRKLRTRGNGKTVRPSSVYRNGTDIIYNYHGIVSLKLEDDSFPTHKRKAKVSIISQPQKTIKVAELPQADKVESTTDSHFPRQDQLPSFPKNCTLELKGLFHFEEGIQKLYQCNGIAWKAWSPQTKDVEDKSCPAGWHQHSGYCHILITEQKGTWNAAAQACREQYLGNLVTVFSRQHMRWLWDIGGRKSFWIGLNDQVHAGHWEWIGGEPVAFTNGRRGPSQRSKLGKSCVLVQRQGKWQTKDCRRAKPHNYVCSRKL", "length": 2179 }, "evidence": [ { "id": "RGD:1306981", "url": "https://alliancegenome.org/gene/RGD:1306981#orthology", "database": "AGR" }, { "id": "HGNC:23399", "url": "https://alliancegenome.org/gene/HGNC:23399#orthology", "database": "AGR" }, { "id": "MGI:2670972", "url": "https://alliancegenome.org/gene/MGI:2670972#orthology", "database": "AGR" }, { "id": "A0A0G2KB00", "url": "https://omabrowser.org/oma/group/A0A0G2KB00/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q684R7-1", "protein_name": "FRAS1-related extracellular matrix protein 1", "gene_name": "Frem1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MHSPGCTGPKAQWFLLLQLLLLHLDRVSATFISINRGLRVMKGSSAFLSGDHLRVAVPKEKDACRLEVVMNEPVTQRVGKLSPQVFDCHFLPNEVKYVHNGCPILDEDSVKLRLYRFTETDTFMETFLLRVYLVEPDCNIIRMSSNVLEVTEFYGLSQAIDKNLLQFDYDRTASLDCTIRLDPLRTQLPAHGKLVVVNRKSEGPRGDQPHSFFSETELGAGLKCPDGSCALELKQVASLKVSCEEFLLTGFHYQHMQPPSPNIDYIPIQLDLTDRRSKTVYKSESAWLPVYIRVGIPNQVPRAAFMAMFVLEVDQFILTPLTTSVLDCEEDETPKPLLVFNITKAPLQGYVTHLLDHTRPISSFTWKDLSDMQVAYQPPNSSHPERRHYTMELEVYDFFFERSAPITVHISIRTADTNAPRVSWNTGLNLLEGQSRAITWEQFQIVDNDDIGAVQLVTIGGLQHGRLTVREGKGFLFTVTDLQAGVVRYHHDDSDTTKDFVAFRIFDGHHSSHHKFPINILPKDDSPPFLITNVVIELEEGKTILIQGSMLRASDMDSSDDYIFFNITKFPQAGEIMKKPGPRLIGYPVPGFLQRDLFSGIIYYRHFGGEIFEDSFEFVLWDSHEPPNLSVPQVVTIHITPVDDQLPKEAPGISRHLVVKETEVAYITKKHLHFLDMESRDGELIYTVTRPPCFSFSHRHLDAGKLFMVDSIPKLTKNPTAPGLSSFTQGLILISANQHTCSSQFASQHAVNHMKVAYMPPMQDIGPSPRHVQFTVSVSNQHGGALHGICFNITVLPVDNQVPEVFTNTLRVVEGGQCTISTEHILVSDVDTPLDSISLSLKERPLHGGVELDGFPLNPRGTFSWRDLNTLKVWYQHDGSEVLQDEIFLEVTDGTNSAAFVLHIEVFPVNDEPPILKADLIPMMHCSEGGEVTITPEYISATDADSDDLELLFLIAREPQHGVVRKAGLHVDRFSQGDVISGAVTYKHTGGEIGLEPCSDTVVLVVSDGEADPLMNGCCYDGPDSSVPLHKSFPTYQLNITVHPVDNQPPSIIIGRMLTVDEGFSAALTTHHLTVVDWDTAPDDLKFMLASQPQFGYLENALPSAGFEKSNIGIRIASFQWTDMKASHINYVQSRHLRVEPTADQFTVYATDGKHRSLETTFHVIINPTNDEAPDLAVQNITVYEGHMVELDSSIISATDRDIPKDPLLFSIALKPQHGLLVDAAISKDSHQIKQLQHEIHSFSVDLLKNGMKLVYAHDDSESSADNFVIQLSDGKHKILKTISVNITPVNDETPTLSKKAEISMAVGDTRVLSSAVLSATDKDSPREKIHYVFERLPQNGQLQLKIGRDWVPLSTGMQCTQEDVDLNLLRYTHAGKTDSQDGDSFTFYLWDEDNRSPAFDCHIIIEDMGKGDIVIHAKPLVVVKGDRGLLTTATLLAVDGADKPEELLYLITSPPRHGQVEYVHSPGVPIASFSQMDIAGQTVCYIHKSRTAVPTDSFRFTISNGLQTQRGVFEITLQTVDSALPVLTKNKRLRLAEGAMGLLSADHLQLTDPDTPPENLTFFLAQLPRHGYLFLRGKALQHNFTQRDVDSGGVAYQHSGGGAREDYFTFLATDRKNQGFVVDGKVQKEPVRFTIQVDQLDKAAPRITHLHSPTQVGLLKNGCYGIYITSRVLKASDPDTEDDQIIFKILRGPLYGRLENTTTGEFIHERFSQKDLSHKTILYIINPSLQVTSDILEFQAMDPTGNTATPQSLDLRWSYIEWAQTAYEVCENVGLLPLEVTRRGYPMDSAFVGVEVNQVSATVGKDFTVTPSKLLQFDPGMSTKMWNIAITYDGLEEDDEVFEVILNSPVNAVLGTQTKAAVKILDSKGGRCHPSNSFNQSKHSTWGKGPWHPLPSGSSSLTTSGSPLLERPPPSFTSGDALQGFGLTDLTQRKTMTQGNGKSVLPSSVCRNGTDTIYNYHGIVSLKLEGDRFSAHKRKAKISIVSQPQRTIKVAELPLADKVESTTDLHFLRQGLRPLFPKNCSVDLKGLFHFEESTHRLYQCDGISWKAWSPQTKGLEDRSCPGGWLLHSGYCHILVTRQKGTWTTATRACREQHQGDLVTVLSRRHMQWLWAMSGRKPFWIGLKNQPRTGHWEWIGGEPVAFTNWRRGAPLHPKPGKNCALVQKRGQWQTKNCSKGKAHNFVCSRKL", "length": 2191 }, "evidence": [ { "id": "RGD:1306981", "url": "https://alliancegenome.org/gene/RGD:1306981#orthology", "database": "AGR" }, { "id": "HGNC:23399", "url": "https://alliancegenome.org/gene/HGNC:23399#orthology", "database": "AGR" }, { "id": "MGI:2670972", "url": "https://alliancegenome.org/gene/MGI:2670972#orthology", "database": "AGR" }, { "id": "A0A0G2KB00", "url": "https://omabrowser.org/oma/group/A0A0G2KB00/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "craniofacial suture morphogenesis", "id": "GO:0097094", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097094", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KB00", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KB00" } ], "pmid": "" }, { "name": "cell-matrix adhesion", "id": "GO:0007160", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007160", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KB00", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KB00" } ], "pmid": "" }, { "name": "cell communication", "id": "GO:0007154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007154", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KB00", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KB00" } ], "pmid": "" }, { "name": "anatomical structure morphogenesis", "id": "GO:0009653", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009653", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KB00", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KB00" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KB00", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KB00" } ], "pmid": "" }, { "name": "basement membrane", "id": "GO:0005604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005604", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KB00", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KB00" } ], "pmid": "" }, { "name": "collagen-containing extracellular matrix", "id": "GO:0062023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062023", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KB00", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KB00" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1062, "end_pos": 1064, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1203, "end_pos": 1205, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1234, "end_pos": 1236, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1259, "end_pos": 1261, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1412, "end_pos": 1414, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1577, "end_pos": 1579, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1601, "end_pos": 1603, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1718, "end_pos": 1720, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1897, "end_pos": 1899, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1971, "end_pos": 1973, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2042, "end_pos": 2044, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2194, "end_pos": 2196, "annotation": "n_glycosylation_sequon" }, { "start_pos": 28, "end_pos": 30, "annotation": "n_glycosylation_sequon" }, { "start_pos": 341, "end_pos": 343, "annotation": "n_glycosylation_sequon" }, { "start_pos": 380, "end_pos": 382, "annotation": "n_glycosylation_sequon" }, { "start_pos": 566, "end_pos": 568, "annotation": "n_glycosylation_sequon" }, { "start_pos": 628, "end_pos": 630, "annotation": "n_glycosylation_sequon" }, { "start_pos": 815, "end_pos": 817, "annotation": "n_glycosylation_sequon" }, { "start_pos": 970, "end_pos": 972, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.agr", "label": "AGR Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 791 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1062, "end_pos": 1064 }, { "start_pos": 1203, "end_pos": 1205 }, { "start_pos": 1234, "end_pos": 1236 }, { "start_pos": 1259, "end_pos": 1261 }, { "start_pos": 1412, "end_pos": 1414 }, { "start_pos": 1577, "end_pos": 1579 }, { "start_pos": 1601, "end_pos": 1603 }, { "start_pos": 1718, "end_pos": 1720 }, { "start_pos": 1897, "end_pos": 1899 }, { "start_pos": 1971, "end_pos": 1973 }, { "start_pos": 2042, "end_pos": 2044 }, { "start_pos": 2194, "end_pos": 2196 }, { "start_pos": 28, "end_pos": 30 }, { "start_pos": 341, "end_pos": 343 }, { "start_pos": 380, "end_pos": 382 }, { "start_pos": 566, "end_pos": 568 }, { "start_pos": 628, "end_pos": 630 }, { "start_pos": 815, "end_pos": 817 }, { "start_pos": 970, "end_pos": 972 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 1 }, { "field": "exact_o_linked_sites", "count": 1 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }