{ "uniprot_canonical_ac": "A0A0G2KAU4-1", "uniprot_ac": "A0A0G2KAU4", "uniprot_id": "A0A0G2KAU4_RAT", "mass": { "chemical_mass": 78529.0, "monoisotopic_mass": 78529.0 }, "refseq": { "ac": "NP_001386473", "name": "ras guanyl-releasing protein 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001386473" }, "gene_names": [ { "name": "Rasgrp3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KAU4", "id": "A0A0G2KAU4" }, { "name": "Rasgrp3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001386473", "id": "NP_001386473" } ], "protein_names": [ { "name": "RAS guanyl releasing protein 3 (calcium and DAG-regulated)", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001386473", "id": "NP_001386473" }, { "name": "RAS guanyl releasing protein 3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KAU4/entry#names_and_taxonomy", "id": "A0A0G2KAU4" }, { "name": "ras guanyl-releasing protein 3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001386473", "id": "NP_001386473" } ], "function": [ { "annotation": "Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras. Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways. Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses. May also function in differentiation of other cell types. Proto-oncogene, which promotes T-cell lymphomagenesis when its expression is deregulated.", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAU4", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KAU4#function" }, { "database": "UniProtKB", "id": "ARBA00056571", "url": "https://www.uniprot.org/uniprotkb/ARBA00056571#function" } ] }, { "annotation": "These results indicate that RasGRP3 is implicated in phorbol ester-induced, PKC-independent exocytosis.", "evidence": [ { "database": "RefSeq", "id": "NP_001386473", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001386473" }, { "database": "PubMed", "id": "15737652", "url": "https://glygen.org/publication/PubMed/15737652" } ] }, { "annotation": "Together these data demonstrate a novel mechanism in which the balance between stability and plasticity in dendritic spines depends on binding of drebrin to actin filaments in a manner that is regulated by Ras.", "evidence": [ { "database": "RefSeq", "id": "NP_001386473", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001386473" }, { "database": "PubMed", "id": "18588530", "url": "https://glygen.org/publication/PubMed/18588530" } ] } ], "disease": [ { "disease_id": "DOID:10763", "recommended_name": { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "hypertension", "description": "An artery disease characterized by chronic elevated blood pressure in the arteries." }, "synonyms": [ { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "HTN", "description": "" }, { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "hyperpiesia", "description": "" }, { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "vascular hypertensive disorder", "description": "" } ], "unlinked_id_list": [ "DOID:11130" ], "evidence": [ { "id": "10763", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10763" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAU4", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KAU4" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "gene": [ { "name": "Rasgrp3", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KAU4", "locus": { "chromosome": "6", "start_pos": 19895390, "end_pos": 19958578, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000032703", "url": "https://www.ensembl.org/id/ENSRNOG00000032703" } ] } } ], "crossref": [ { "id": "RGD:1304612", "url": "https://alliancegenome.org/gene/RGD:1304612", "database": "AGR", "categories": [ "Protein Classification" ] }, { "id": "A0A0G2KAU4", "url": "https://alphafold.ebi.ac.uk/entry/A0A0G2KAU4", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSRNOG00000032703", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000032703", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00051", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00051", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00155", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00155", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06224", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06224", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20862", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20862", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "313874", "url": "https://www.ncbi.nlm.nih.gov/gene/313874", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000651", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000651", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001895", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001895", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002219", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002219", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008937", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008937", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020454", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020454", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023578", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023578", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036964", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036964", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046349", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046349", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "QNRVTHR", "url": "https://omabrowser.org/oma/group/QNRVTHR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A0G2KAU4", "url": "https://www.orthodb.org/?gene=A0A0G2KAU4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23113", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23113", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23113:SF178", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23113:SF178", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00130", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00130", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00617", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00617", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13499", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13499", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-1169092", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1169092", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-5673001", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5673001", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001386473", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001386473", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1304612", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1304612", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A0G2KAU4", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KAU4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2KAU4-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KAU4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3ZZN2", "url": "https://www.uniprot.org/uniprotkb/D3ZZN2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3ZZN2-1", "url": "https://www.uniprot.org/uniprotkb/D3ZZN2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGSNGLGKAATLDELLSTCIEMFDDNGELNDSYLPRIMLLMHRWYLSSTELAGKLLCMYRNASGESCDEFRLKICYFMRYWITKFPAEFNLDLGLIRMTEEFREVASQLGYEKHSNLMDISSIPSYDWMRRVTQRKKVSKRGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSKPSAQQRAEVITKFINVAQKLLQLKNFNTLMAVVGGLSHSSISRLKDTHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWMEENKVNVVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWASEVVPKPDPTIINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMNYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRLARAPSLSSNPESLPGSPALPPVQDEVFEFPGVTARHRDLDSRDITLVTGSSRKISVRVQRATTSQATQTEPVWSEAVWGDSGSHTFPKMKSKLHDKAAKDKGFAKWENEKPTLHAGVDVVDRGTAFEPDQDDEQDEAQQGVEDG", "length": 691, "header": "tr|A0A0G2KAU4-1|A0A0G2KAU4_RAT Isoform 1 of RAS guanyl releasing protein 3 OS=Rattus norvegicus OX=10116 GN=Rasgrp3 PE=3 SV=1 CANONICAL=A0A0G2KAU4-1" }, "isoforms": [ { "isoform_ac": "A0A0G2KAU4-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KAU4/entry#A0A0G2KAU4-1", "sequence": { "sequence": "MGSNGLGKAATLDELLSTCIEMFDDNGELNDSYLPRIMLLMHRWYLSSTELAGKLLCMYRNASGESCDEFRLKICYFMRYWITKFPAEFNLDLGLIRMTEEFREVASQLGYEKHSNLMDISSIPSYDWMRRVTQRKKVSKRGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSKPSAQQRAEVITKFINVAQKLLQLKNFNTLMAVVGGLSHSSISRLKDTHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWMEENKVNVVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWASEVVPKPDPTIINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMNYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRLARAPSLSSNPESLPGSPALPPVQDEVFEFPGVTARHRDLDSRDITLVTGSSRKISVRVQRATTSQATQTEPVWSEAVWGDSGSHTFPKMKSKLHDKAAKDKGFAKWENEKPTLHAGVDVVDRGTAFEPDQDDEQDEAQQGVEDG", "length": 691, "header": "tr|A0A0G2KAU4-1|A0A0G2KAU4_RAT Isoform 1 of RAS guanyl releasing protein 3 OS=Rattus norvegicus OX=10116 GN=Rasgrp3 PE=3 SV=1 CANONICAL=A0A0G2KAU4-1" }, "locus": { "chromosome": "6", "start_pos": 19932248, "end_pos": 19897562, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000079819.2", "url": "https://www.ensembl.org/id/ENSRNOT00000079819.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000075529.1", "url": "https://www.ensembl.org/id/ENSRNOP00000075529.1" } ] } }, { "isoform_ac": "D3ZZN2-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KAU4/entry#D3ZZN2-1", "sequence": { "sequence": "MGSNGLGKAATLDELLSTCIEMFDDNGELNDSYLPRIMLLMHRWYLSSTELAGKLLCMYRNASGESCDEFRLKICYFMRYWITKFPAEFNLDLGLIRMTEEFREVASQLGYEKHSNLMDISSIPSYDWMRRVTQRKKVSKRGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSKPSAQQRAEVITKFINVAQKLLQLKNFNTLMAVVGGLSHSSISRLKDTHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWMEENKVNVVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWASEVVPKPDPTIINKHIRKLVELWGIIKQGYKCKDCGANCHKQCKDLLVLACRRLARAPSLSSNPESLPGSPALPPVQDEVFEFPGVTARHRDLDSRDITLVTGSSRKISVRVQRATTSQATQTEPVWSEAVWGDSGSHTFPKMKSKLHDKAAKDKGFAKWENEKPTLHAGVDVVDRGTAFEPDQDDEQDEAQQGVEDG", "length": 603, "header": "tr|D3ZZN2-1|A0A0G2KAU4_RAT Computationally mapped isoform of RAS guanyl releasing protein 3 OS=Rattus norvegicus OX=10116 GN=Rasgrp3 PE=3 SV=1 CANONICAL=A0A0G2KAU4-1" }, "locus": { "chromosome": "6", "start_pos": 19932248, "end_pos": 19897562, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000051239.5", "url": "https://www.ensembl.org/id/ENSRNOT00000051239.5" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000051116.3", "url": "https://www.ensembl.org/id/ENSRNOP00000051116.3" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "RasGRP3 mediates phorbol ester-induced, protein kinase C-independent exocytosis.", "journal": "Biochemical and biophysical research communications", "date": "2005", "authors": "Ozaki N, Miura Y, Yamada T, Kato Y, Oiso Y", "evidence": [ { "database": "RefSeq", "id": "NP_001386473", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001386473" } ], "reference": [ { "type": "PubMed", "id": "15737652", "url": "https://glygen.org/publication/PubMed/15737652" } ] }, { "title": "Interactions between drebrin and Ras regulate dendritic spine plasticity.", "journal": "The European journal of neuroscience", "date": "2008", "authors": "Biou V, Brinkhaus H, Malenka RC, Matus A", "evidence": [ { "database": "RefSeq", "id": "NP_001386473", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001386473" } ], "reference": [ { "type": "PubMed", "id": "18588530", "url": "https://glygen.org/publication/PubMed/18588530" } ] } ], "pathway": [ { "id": "R-RNO-1169092", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1169092", "resource": "Reactome", "description": "Activation of RAS in B cells" }, { "id": "R-RNO-5673001", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5673001", "resource": "Reactome", "description": "RAF/MAP kinase cascade" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0N4SVF2-1", "protein_name": "RasGEF domain family, member 1A", "gene_name": "Rasgef1a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFLEPQEAMPQTSVVFSSILGPNCNRQVQPGMGERGGGASSGSKDLIFQDGRLTSGSLEALMEHLVPTVDYYPDRTYIFTFLLSSRVFMPPHDLLARVGQICLEQRQQLEAGPEKAKLKSFSTKIVQLLKEWTEAFPYDFQDEKVMAELKAIAHRVTQCDEENGTVKKAIAQMIQSLLLSLAARSQLQELREKLRSPVVDKGPVLKAKPPAAQKDILGVCSDPLVLAQQLTHIELERVNSIRPEDLMQIISHMDSLDNHRCRGDMTKTFSLEAYDNWFNCLSMLVATEVCRVVKKKHRTRMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKVKTAKFDVLEHHMDPSSNFCNYRTALQGATQRSQTANSSREKIVIPVFNLFVKDIYFLHKIHTNHLPNGHINFKKFWEISRQIHEFMTWTQVECPFEKDKKIQSYVLTAPIYSEEALFIASFESEGPENHMEKDSWKALRTTLLNRA", "length": 489 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A4X1T4J2-1", "protein_name": "RAS guanyl releasing protein 3", "gene_name": "RASGRP3", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MGSSGLGKAATLDELLSTCIEMFDDNGELNNSYLPRIVLLMHRWYLSSTELAGKLLCMYRNASGESCDEFRLKICYFMRYWILKFPAEFNLDLGLIHMTEEFREVASQLGYEKHVSLIDISSIPSYDWMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNLDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPTKPMVPLEWASGVLPKPDPTVINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFVHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRFARATSVGSSHGSLPGSPSLPPVQDEVFEFPGVAAGHRDLDSRAITLVTGSSRKISVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDKATKDKGFAKWENEKPRVQAGVDVVDRGTAFELDQEEADMGETRQDGEDG", "length": 692 }, "evidence": [ { "id": "A0A0G2KAU4", "url": "https://omabrowser.org/oma/group/A0A0G2KAU4/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "A0A5F8MPI9-1", "protein_name": "CRK SH3-binding GNRP", "gene_name": "Rapgef1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGNAVEKQKPLRQSHLCPWKQDSQRSHLSSFTMKLMDKFHSPKIKRTPSKKGKPAEVSKIPEKPVSKEARDRFLPEGYPIPLDLEQQAVEFMSTSAVASRSQRQKNLCWLEEKEKEVVSALRYFKTIVDKMAIDKKVLEMLPGSASKVLEAILPLVQTDPRIQHSSALSSCYSRVYQSLANLIRWSDQVMLEGVNSEDKEMVTTVKGVIKAVLDGVKELVRLTIEKQGRPSPTSPVKPSSPASKPDGQPELPLTDREMEILNKTTSVSPSAELLPDSTSEEVAPPKPPLPGIRVVDNSPPALPPKKRQSAPSPTRVAVVAPMSRATSGSSLPVGINRQDFDVECYTQRRLSGGSRSCGGESPRLSPCSSTGKLSRSDEQLSSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQIPPQAACNLSPLPESLGESGPPFLGHPFQLPLGSCLQQEGQQTDTPPALPEKKRRSAVSQTTDSSGCRVSYERHPSQYDNISEGDLQNPVPVQPVPYPPFAAVLPFQQGASSASAEFVGDFSVPELAGDTEKPPPLPEKKNKHMLAYMQLLEDYSEPQPSMFYQTPQSEHIYQQKNKMLMEVYGFSESFCGSDSTQELAPPPALPPKQRQLEPPSGKDGHPRDPSVSSASGKDSRENGERSPKSLDGLESAQSEEEVDELSLIDHNEIMARLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLVLYCEAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTEEILKLLMELVFRLVCSGELSLARVLRKNILDKVDQKKLLRCAHSDQPLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQRQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQFNILDSMRCFQQAHYEIRRNDDIINFFNDFSDHLAEEALWELSLKIKPRNITRRKTDREEKT", "length": 1087 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A0A8I5YCN5-1", "protein_name": "Rap guanine nucleotide exchange factor 6", "gene_name": "Rapgef6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNSPVDPGARQALRKKPPERTPEDLNIIYSYLHGMEILSNLREHQLRLMSTRARYERYNGNQMLFCSETIARCWYILLSGSVLVKDSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVVENSKDNEDSILQREIPARQSRRRFRKINYKGERQTIIDGVDVNNYLSLPADLTKMHLTDNPHPQVTHVTSSQSGCSIASDSGSSSLSDIYQATESEVGDVDLTRLPEGPVDSEDEEEEEEEIDRTDPLQGRDLVRECLEKEPADKTDDDVEQLLEFMHQLPAFANMTMSVRRELCSVMIFEVVEQAGAVILEDGQELDSWYVILNGTVEISHPDGKIENLFMGNSFGIVPTLDKQHMRGVVRTKVDDCQFVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVHEHRELDRSGTRKGHIVIKATPERLIMHLIEEHSIVDPTYIEDFLLTYRTFLETPLDVGIKLLEWFKIDSLRDKVTRIVLLWVNNHFNDFEGDPAMTRFLEEFEKNLEDTKMNGHLRLLNIACAAKAKWRQVVLQKASRESPLHFSLTGGSEKGFGVFVEVVEPGTKAADAGLKRGDQIMEVNGQNFENITFAKALEILRNNTHLALTVKTNIFVFKELLSRTEQEKSGVPHIPKIAEKKSNRHSIQDVPGDIEQVPQEKGNKKIKANTVSGGRNKIRKILDKTRFSILPPKLFSDGGLSQSQDDSIVGTRHCRHSLAIMPIPGTLSSSSPDLLQPTTSMLDFSNPSDIPDQVIRVFKADQQSCYIIISKDTTAKEVVCQAVQEFGLTGASDTYSLCEVSVTPEGVIKQRRLPDQFSKLADRIQLNGRYYLKNNMETETLCSDEDAQELLKESQLSMLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKLDSKTGNTHLKQFEDIVNQETFWVATEILSESNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRGTWEKLPSKYEKHLQDLQDLFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFLHEGNDSKVDGLVNFEKLRMIAKEIRHIIRMTSANMDPAMMFRQRSLSQGSTNSNMLDVQGGAHKKRARRSSLLNAKKLYEDAQMARKVKQYLSSLDIDTEEEKFQMMSLQWEPAYGTLTKSLTEKKSARSSEMSPVPLRSAGHTAKVHLHQPHRVSQVLQVPAVNLHPIRKKGQTRDHVLSTNLPQKGLGPTEEVSGKKHTEDTISVASSLHSSPPASPQSSPRKGCTLTPSSKCDNLSDSSHSEISSRSSIVSNGSVDSMSAAGQDERCSAHSLAVPEPTGAWEKTDHPSGISDHSQLAHGWMLSKPSLIKGVAVSSSLSSEEMSQEHVVLEAADSGRGSWTSCSSSSHDNFQSLQNQKSWDFLNSYRHTHLGDPIAEVEPPDCEPCACPKGCSRTCSQCKGSLETNQLRQSWASSSSLSDTWEPNYGTVKRRVLESTPAEAPDGLEPRDTSDPVYKTVTSSTDKGLIVYCVTSPKKGDRHREPPPTPPGYLGISLADLKEGSHPHLKPPDYSVAVQRSKMMLLNSLSRLPPAPPSSHTSAWVPSKIGSQPQRHSLQPSHPKLADVADADSEADEQASCVD", "length": 1605 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6G621-1", "protein_name": "RasGEF domain family, member 1A", "gene_name": "Rasgef1a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPQTSVVFSGTLGPNCNRPVQPGMGERGGGASSGSKDLIFQDGRLTSGSLEALMEHLVPTVDYYPDRTYIFTFLLSSRVFMPPHDLLARVGQICLEQRQQLEAGPEKAKLKSFSTKIVQLLKEWTEAFPYDFQDEKAMAELKAIAHRVTQCDEENGTVKKAITQMIQSLLLSLAARSQLQELREKLRSPVVDKGPVLKAKPPAAQKDILGVCSDPLVLAQQLTHIELERVNSIRPEDLMQIISHMDSLDNHRCRGDMTKTYSLEAYDNWFNCLSMLVATEVCRVVKKKHRTRMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKVKTAKFDVLEHHMDPSSNFCNYRTALQGATQRSQTANSSREKIVIPVFNLFVKDIYFLHKIHTNHLPSGHINFKKFWEISRQIHEFMTWTRVECPFEKDKKIQSYLLTAPIYSEEALFIASFESEGPENHMEKDSWKALRTTLLNRA", "length": 481 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8M2B4V9-1", "protein_name": "RAS guanyl-releasing protein 3 (calcium and DAG-regulated)", "gene_name": "rasgrp3", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGSFTLGKAASLELLLDACIHAFDDKGELHENQLPRTFLLMHRWYVSSTELAGKLLIMYRDCRGDDCQRTRLKICYLMRYWIAEFPAEFDLDLGLIRLTEEFRDAAAELGGDKHIKLLDISTIPSYDWMRKLTQRKKQVKKGKASLLFDHLEPIELAEHLTFLEYKSIRRISFTDYQSYVIHGCLVDNPTLERSIALFNGISQWVQLMVLSKLTPQHRAEVITKYIHVAQKLLHLQNFNTLMAVVGGLSHSSISRLKETHSHLSPEVTKIWNEMTELVSSNGNYCAYRKAFGESKGFKIPILGVHLKDLIAVHVVFADWVEDGKVNIAKMQQLFLTFNELVSLQSAVAQVEPNMDLIYLLNLSLDLYYTEDEIYELSLLREPRNPKSQPTSPTTPNKPLAPLDWASGVTTKPDPSVVNKHIRKVVDSVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRANPLLQCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGVNCHKQCRELLVLACRRLPRSTSLGSVSPGVLTHSSLPSSPNLPTCKDDDEVFTFPTVSPSSGSDLEGKSITLMTGSAQRISVRLQRATTSQATQTEEHLWPENGWAAVADSGSHTFPKMRYRPHHKASKSKGFARWENDTQGSMGTRNSRNSQEHSEESQQNGLTEQHTNKTRTSEIS", "length": 708 }, "evidence": [ { "id": "RGD:1304612", "url": "https://alliancegenome.org/gene/RGD:1304612#orthology", "database": "AGR" }, { "id": "MGI:3028579", "url": "https://alliancegenome.org/gene/MGI:3028579#orthology", "database": "AGR" }, { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-070424-82", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-070424-82#orthology", "database": "AGR" }, { "id": "HGNC:14545", "url": "https://alliancegenome.org/gene/HGNC:14545#orthology", "database": "AGR" }, { "id": "A0A0G2KAU4", "url": "https://omabrowser.org/oma/group/A0A0G2KAU4/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8M2BED2-1", "protein_name": "CRK SH3-binding GNRP", "gene_name": "rapgef1a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSGKIDSKQESQRSHLTSFTMKLKDKFHSPKIKRTPSNKKSKPPPEQPVKSPEKTVTKSLSRLEEHEKEVVSALRYFKTIIDKMAVDKKVLEMLPGSASKVLEAVTGLVQLDSKILSSSRVSSCLNRLYQSLANLIRWSDQVMLEGVNLEDKDTITTVTNVIKAVLDGVKELVKVAIEKQEHPSPTTPVKTIPPVASPQRVPEPPVIETKEPILNDSPAPAENIETPNDVPEEEVAPPKPPLPGLKVPEQHCPPALPPKKRQSAPSPTRIAVVAPMSRTTSGSSLPIGICRQEYEADALQRRFSGGSHSYGGESPRLSPCGSIGILSKSDEQLSSLDQDSGQCSRNTSCETLDTAESYDPDYDFLHQDLSSTEQIPHTHTGGCLSPLPESLHESSSFPVQHQSMPPALPKKERRPPLPPVERLYSQYDNVPDEDMHTPPFPLFGAIPPSNPGVFMGNFGPSENTQIPQSPPPLPEKKSRHILKYMQFMEDYSEPLPSVFYQTPQSESIYEQRNRKRFQEVYGLSDSFSSSDETLPPPALPPKQRQLASSHSASPSSSSSSSLSCQLQQCVSGPGPGETESTLSLSASNSSLNREGSLPVPTSESANDEGGEGEYVNLYSSNQANGDVTLSNGDSFCGAEDSPQDSAIEHSKDPADREGWKQKCVDSDLTSEEVDELCLIDHDEIMSRITLKQENDDGPDVRAGSGDILLVHATETDRKDRVLYCEAFLTTYRTFLTPEDLIKKLRYRYTRFSLSSDSIKQRASKNTFFVLVRVVDELCLVELTEDILKQLMELVFNLLCKGELTLARVLRKNILDKVQQKKLLQYTNSLKTLAARGVAARPGTLHDFRSHEIADQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIILQEKAQDREKLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQKQTSEGLEEYCTLIDSSSSFRAYRAALADVEPPCIPYLGLILQDLTFVHLGNPDHIEGKINFSKRWQQFNILDTMRRFQQVHYDLKHNDDIVSFFNDFSDHLAEEALWELSLKIKPRNITRRKTEREEKT", "length": 1085 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8M2BIN3-1", "protein_name": "Rap guanine nucleotide exchange factor 2", "gene_name": "rapgef2a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MHADRMASYVDNSFRHAIMKIPADRTQQDLQIVYSYLHGMEALSNLREHQLRLMCETVRYEQHDANEVLYYPDDIGTCWYILLSGSVFIKESMFLPRSSFGKRSAGSLRRGCECIVLEASEMIVVDYMDDNDEYFQRQASHRQSRRRFRKINQRGERQTIIDTVDNYPVSKPPLPPGYHSECPKSQLPTDFSKLHPSDSCHSHMTSSQSRSSIASDSGSSSLSDIYQATESECGDMDLSGLPETAVDSDEDDDDEDVGRGTDHLMSRDIVRDCLEKDPMDRTDDDIEQLLEFVQQLPAFASLSVSVRRELCAVMVFAVVERAGTIVLNHGEELDSWSVILNGAVEVIYLDGRSESVCMGGSFGVCPSMEKQLMIGVMRTKVDDCQFVCIAQQDYCCILNQVEQNTQRVEEEGEIVMVKEHRELDRTGTRKGHIVVKGTAERLMQHLVEDHSIVDPTYIEDFLLTYRTFLPSPLILGQRLLDWFNDPCLRDRVTRVVLLWVNNHFSDFEGDPDMTSFLEEFQSNLEREKMTGQLRLLNIACAAKAKPRVITVTRTAREIPLPFTLIGGAERGTRLFISSVEVGSKAEEAGLKRGDQILEVNGQTFENVQLSKATEILRNNIQLSMSVKTNLLVFKELVARVAEERKNGVPHLPKIGDGKKNCRYSIPELGAGSDVIGQEKISKKAKAHTVGGRNKLMKILDKTRMSILPQKPYSDLGLGQTQDDSIVGLRQNKQTPPTMPVSGTLSSSNPDLAQGQQRIIDYSTQPPAPGFTQLQDQVLRIFKADQQSRYLLANRDTTAREAANLAIKEFGLSASPEAFSLCEVSVTQEGVIKQRRLPDQLSKLADRIQLSARYYLKSNMETETLCSDVEALEMQRESVVPLLSLSSMEIANQLSARNYLLFSCIEPTDYINDLFKLHPQEPPTNLRNFEGLVNQETFWVATEIVQETNLAKRVKIIKHFIKIALHCRDCKNFNSMFAIISGFNLAPVSRLRSTWERLPGKYEKLLAELQDVFDPSRNMAKYRNLLNKHNLQPPVIPLFPVIKKDLTFLHEGNNSEVDGLVNFEKLRMIAREIRHVVRMASITMDPALLFKTRKKKWRSLGSLSQVSSSSLSDIGTMGGKRKGRRSSFLSAKKLYEVEMMSRRVRQYLDTHSNESNEDTLHELSMTCEPANSSTLKHAGERRRIDASPAGQRSASPQQTNGNHGRKKSISKELPFEGRDRQRKLPEDSQSSTSSILSSPRNSPQSTPRKGPQLVVSEVSDQMSLLSSSSSELLMVDDHTHTQPHSLAHPLSARRAEPDQLSLGSYSLTQDQCDRASLDAADSGRGSWTSCSSGSHDNIQSIPQRVGYYDSRSWEMLSDGMGRSHMTTPTGYWADELEGDTGTIKRRGGKDETPNTNKNTVSRREGHFREPPPTPPGYTAVSLAEADTNSHAHGRRPPDYSAALQRSRFLKRTCDPPPLHSSSRLPPYSHCQTPRRSQADESEQISAV", "length": 1486 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8M2BLA4-1", "protein_name": "RAS guanyl-releasing protein 4 isoform X1", "gene_name": "rasgrp4", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGFDTMNRKESKSSRKSRQEGGIKSRRPVQRRMTCPSAQEISRALQSPPAHASFRSASLDELILRCLHCFDSDGKLNRGTQLVSMTLMMHNWVVPSHIFAHKLLSLYKDCPAEKRGQRRPQICHFIRQWISQFRLMFEMDPLLEKAMGDLWALVSAEGTNSHHQLINTPYINPPVNISQTPSPLVKKRKVSLLFDHMEPDEMAEHLSYLEFKNFCNVSFLDYRSYVVHGSVRDNPALERSVMLCNGVSQWVQLMILNRHTSQQRAEVFTKFIHVAQKLRSLQNFNTLMAVIGGLCHSSISRLKDTASLLSSDVTKTLSELTELLSSYSNYSNYRRVYSECTGFKVPILGVHLKDLISLNEALPDYLEDDKINLGKLQHLYSNISDLLAIHDCTPPFEANKDLLHLLTLSLDLYYTEDEIYELSYAKEPKNPKIQPVAPVKPPVVAEWGSGVTPRLDPATISKHVKQMVDSIMKNYDLNMDGYISLEEFEKIAANFPFSFCTHESDREGEISREEITSYFMRGMSVCAKLGFNLHNLHNFHETTYKRPTFCDTCGGFLWGVIKQGYHCKDCGVNCHKHCKDVVGMECLKRLQVNSSSCPCTPGPVSGLHTKGNSWSEFSQSFQSGSEEEAFVFPNGNESEHSKGQTSSDSDAEAATLSDRSTQTEPGVWTPVAKRKDRLHSQKQHPPLEKSATLPARVRGSSAPSSLLQEKMDELKLNKDKRKEPD", "length": 725 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8M3B5Z6-1", "protein_name": "Ras-specific guanine nucleotide-releasing factor 2-like isoform X1", "gene_name": "rasgrf2a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MQKSVRYNEGHALYLSMVARKEGIKRGHLSKKAAENNRWNEKYFALYQNVLFYFENEQSTRPSGIYLLEGSTCERIPAPKVSTVGKESSDKQQHYFLVIFGHDGQKPLELRSEEEADCNEWVEVIQQASYSDLIIEREVLMQKYIHLVQIMETEKVAANQLRTQLEDQDTEIERLKAEIVVLNKSKERMLPFQSFQDEEDPDIKKIKMVQSFMRGWLCRRKWKIIVQDYICSPHAESMRKRNQIVFNMVEAETEYVLQLSILVNCFLRPLRMAASSKKPPISHDDVSSIFLNSETIMFLHEIFHQGLKARIANWPTLVLADLFDILLPMLNIYQEFVRNHQYSLQVLANCKQNRDFDKLLKQYEANAACEGRMLETFLTYPMFQIPRYIITLHELLAHTPHEHVERKSLEFAKSKLEELSKMMHDEVSDTENIRKNLAIERMIVEGCDILLDTSQTFVRQGSLIQLPSVEKGKLSKVRLGSLTLRKEAERQCFLFTKHFLICTRTSGGKLHLLKQGGTLSLIECTLIEELDTSDEDYNAAGQGLNHLEFKIVVEPADGSSFSVVLLAPSRQEKAAWTSDISQCIDNIRCNGLMNSVFEDNSKVTVPHMIKSDARLHKDDVDICFSKTLNSCKVPQIRYASVERLLERLTDLRFLSIDFLNTFLHTYRIFTTAAVVMDKLADIYKKPFTSIPVRVQYHSSDRLSITSICPDYSLKITRLALDQSKSLELFFATNQGPWSGEHLNNKSPRLSRKFSSPPPISITSRTSSPIHSRKLSLSSPVSCKAGALDLSTSTFSAASSPTSPYNPIICSPPPTCTKAPLDLSRGPSSPELCPSTPEEGGELPRIDAFCGKLRRSIRRAVLESVSLDKFIPETPTSSDSGEMSPSRSPSTPRHLRYRQPAGQCPDNSRCAVSPASAFAIATAAAGHSSPQGFTNPEKSYDKEFLIRRAATNRVLNVLRHWVSKHSQDFEMNAELTTAVMALLEEVLRDPDLLPQERKAAVNILSALSQEEQDDSQLKIEDIVQMVDCPRAECFESLSAMELAEQITLLDHIVFRNIPYEEFLGQGWMKMDKNERTPYIMKTSQHFNDMSNLVASEIMAHADVSSRAGSIDKWLAVADICRCLNNYNGVLEITSALNRSAIYRLKKTWAKVCKQTKALMDRLQKIVSSEGRFKNLRETLKNCNPPCVPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQAPYRIELQPKVTQFLLDKTLVMDEDTLYELSLKIEPRLPPAN", "length": 1274 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8M9PTQ9-1", "protein_name": "CRK SH3-binding GNRP", "gene_name": "rapgef1b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGNSSRRTQPLLEDTDYFNPGEADTESQKSHLSSFTMKLMKFHSPKIKRTPSKKGKQLQPEPAVKTPEKPVNKKVSRLEEQEKDVVSALRYFKTIVDKMNVDTKVLQMLPGSASKVLEAILPLMQVEARIQHSSAMSSCHNRVYQSLATLIRWSDQVMLEGIDLDDKDTVTTVTTVIKAVLDGVKELVKLTIEKHDQPSPTSPSKPAPPVAKTESGCENPLTEREKAILSKTTPIVTPTDSLTDMSEEEAPPKPPLPGPKLAEHRNRMQLCSDPVTGQRRATMMETPPALPPKKRQSAPSPTRVAVVAPMSRGPCSLSLPPGALRQQQDFDVDLLQRRFSGGSQSYDGESPRLSPCNSMGKLSKSDEQLSSLERDSGQCSRNTSCETLEGYDPDYDFLNQDLSVSEPLPFPTNTGGSLSPLPECNTESQSLSPAHIPARPRFSAPVTNQASLDYWTPPLTPGQGNSVLPPALPQKKRRSAPIISAYPLYERLPSHYDNLSEEEQPTPPFPLVTPGSPQVNGDGVLQYTDADSPPPLPEKKGKQILQYMQFVEDYSEPQPSVFYQLPQSESIYEQRRNKRFQEVYGLNDSYSSSDSIPASAADPHERVPPPALPPKLRQLASNTTTFPPSSSSSAFSTLPPPAGLPEEVEPALGLSLSVSSSFLSGHASLTTPVSSEPVGLTNSGRALDGGGVSNGSLTSSLLSLAVCLPSESSLSDSLLTSASESIDESGEGEYVNLYSSTQANGENTHRTESLSCDDVLQDHSPHIPSSNSKEALTKERPKEASHGHIDDVDELSLIDHNDIMNRITLKAENDDGPDVRAGSVDILLVHATETDRKDLVLYCEAFLTTYRTFITPEDLIKKLHHRYTRFCHSPDTFKKRVSKNTFFVLVRVVDELCLVELTEDILRQLMDLVFRLVCNGELSLARVLRKNILDKVEQKRLLQHMHTLRPLAALGVSARPGTLHDFRSHEIADQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIIQQEKAQDREKLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQKQTSEGLEEYCTLIDSSSSFRAYRAALAEVEPPCIPYLGLILQDLTFVHLGNPDFIEGKVNFSKRWQQFNILDSMRRFQQVHYDLKRNDDIVSFFNDFSDHLAEEALWELSLKIKPRNISRRRTEREEKT", "length": 1204 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8N7TAP0-1", "protein_name": "RAS guanyl-releasing protein 2", "gene_name": "rasgrp2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MESVSWDQPASVVELVEACIKAFDNEGVLKDPSLVRMFLTMHPWYLSSSDLAKKLLQKSQQQDCSANRQSQICHLVKYWISEFPAEFDLNPALAEQIRGLKERLEQNGDVRRSLLIDIDSIPSYEWRRQLDETVQKKRKTSLLFDHLDASTLAEHLTYMEYKSFCKILFQDYHSFVMHGCTVDNPILERFITLFNSVSQWIQIMVLSKPTAQQRATVISEFIKVAERLLQLQNFNTLMAVVGGLSNSSIARLKNTQALISSDTRKVFDGLVELVTSFGNYSRYRQRFSECSGFRFPILGVHLKDLIAVHVALPDWIDPEKTRVNLTKTYQLYAILEELALIQSTPPNIEANTDLLNLLIVSLDQYHSEDDIYQLSLQREPRSIKLSTSSSKSQSPLIEQWASSVKPKADPSIINKHIEKMVESVFQNYDTDGDGYISQEEFEIIRSNFPYLGKFDELDQNQDCKISREEMIEYFTKASSLQNCKMGFVHTFAETSSIKPSFCRHCSRLIWGFYNQRCKCKVCGVSCHKDCVSRLAIECRKRTQSVSVYNDVSSKATRSFSFPPPQSTETIAESPVICTDPLQDQDEVFDVYL", "length": 592 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A1Z6P8-1", "protein_name": "Exchange protein directly activated by cAMP, isoform E", "gene_name": "Epac", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAMEWITAMDKRPCDRNLRDVELISCRLRRVEPLCRLPGSALQQLAMCGFYEDLEKGVTLFRAGEQGRFWYAVLGGSLEVRYHAHADADGKSAVTLCNLGVGATFGESVLHDLPRDSTVVTKTTCELLRVEQQDFRLIWEKNKELMNDIFTNCKLKNGFGPSVQATAAATSPTKRPLSPDHPNPALPITETPSPAMNRMGWALRTLLVADNSSCLKDRKVSGKLIRKCAPGTELVDWLVNLSPIVHTRAQAAGMWQALLEEGVLAHVNKEQPFKDKCFLYRFRIDEEGGTAAAGVPQAEDLGAANEHIREALSALFQRGPDATLRMILRKPSHERTSEELELVFEELVHIAALSHLSTSIKRELSSIFVFEAHAQAGTILFNQGDEGRSWYILLKGSVDVVIHGKGTVATLKTGDDFGKLALINDAPRAATIVLKENNCHLLRVDKEHFNRILRDVEANTLRLQEHGKDVLVLERVAKQRGQHSAFKYTVMSGTPAKMLEHLLETRLGQSVGGMDPFLDDFLLTHIVFMPVVQLVDELANYFHCDAHEDAQTPEDREYIINFKKRVIQFMQKWVMAVRHAAFEEPSVCDFIEDLAAEVEADPDLNEETSIVHNVLTQMARYQEDRNQNAGQKWKLPPNGQPICLFSGNATPSKTVIRPDDDIIFRVYCADHTYCTLRFPMHTTAELIKACAADKLQLNRGPEDLVLVEVKSNGERSVFKDNDVSIPTGLSLNGRLFVSVKDHLDALTQLQEQECPTEGVDIDLEILSTKELAYHITLFEWDLFWAVHEYELLYHTFGRHHFGKITANLDVFLRRFNEVQYWIVTELVSTPSLSKRVGLVRKFIKLAAYCKEYQNLNAFFAVVMGLSNMAVSRLQQTWEKIPSKFRKIFQEFEALIDPSRNHRAYRVFVGKLQPPLIPFMPLLLKDMTFAHEGNKTSLDGLVNFEKMHMMAQTMRTIRFCRSRSLGLEPPSPKSEGEVRSYISSFRVIDNQRVLTAMSQKVEPTRKL", "length": 1006 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "A2CEA7-1", "protein_name": "Ras-specific guanine nucleotide-releasing factor 2", "gene_name": "rasgrf2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MQKSVRYNEGHALFLSVIARKEGTKRGYLSKKTTENSKWHEKFFALYQNVLFYFDTDQSARPSGIYLLEGCTCERVPALKVSTVGKDALDKLQYFLVVFGHDGQKPLELRTEEESDCDEWVEAIQQASYSDIIIEREVLMQKYIHLVQIVETEKVAANQLRTQLEDQDTEIERLKAEIIALNKTKERMRPYHVFQEEEDPDIKKIKKVQSFMRGWLCRRKWKIIVQDYICSPHAESMRKRNQIVFNMVEAETEYVHQLSILVNCFLRPLRMAASSKKPPISHDDVSSIFLNSETIMFLHEIFHQGLKARIANWPTLVLADLFDILLPMLNIYQEFVRNHQYSLQVLANCKQNRDFDKLLKQYESNAACEGRMLETFLTYPMFQIPRYIITLHELLAHTPHEHVERKSLEFAKSKLEELSRVMHDEVSDTENIRKNLAIERMIVEGCDILLDTSQTFVRQGSLIQLPSVERGKLSKVRLGSLSLKKEGERQCFLFTKHFLICTRSSGGKLHLLKQGGVLSLIECTLIEEPDANDEDAKNSGQVFGHLDFKIVVEPSDAPAFTVVLLAPSRQEKAAWTSDISQCIDNIRCNGLMTSVFEENSKVTVPHMIKSDARLHKDDVDICFSKTLNSCKVPQIRYASVERLLERLTDLRFLSIDFLNTFLHTYRIFTTATVVMEKLADIYKKPFTSIPVRSLELFFATNQNNRSGDHVNDKSPRLCRKFSSPPPLSISSRTSSPVRTRKLSLNSPIGSKVGILDLSTTSSSAASSPTSANPTISPPPSNNNNNSKPPLDLSRGQSPSSPEQSPGALDDNAEVPRIDALCGKLRRSIRRAVLESVSLDKFIPESPQASEPGEISPCRSPSTPRHLRYRQSGVQTAENSRCSVSPASAFAIATAAAGHSSPPVFNNSERTCDKEFIIRRAATNRVLNVLRHWVSKHSQDFEMNGELKMGVICLLEEVLRDPDLLPQERKATANILSALSQDDQDDAQLKIEDILQMAECPKAECFESLSAMEIAEQITLLDHIVFRSIPYEEFLGQGWMKTDKTERTPYIMKTSQHFNDMSNLVASQIMSHTDVGSRAGSIEKWVAVADICRCLNNYNGVLEITSALNRSAIYRLKKTWAKVCKQTKALMDKLQKTVSSEGRFKNLRETLKNCNPPCVPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQTPYRIEHQPKVTQYLLDKTLIMDEDTLYDLSLKIEPRLPA", "length": 1244 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A5PLJ4-1", "protein_name": "Zgc:165655 protein", "gene_name": "rapgef5b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MELGNESPSFKDLVCKVLEVHKSRTDPPRLLKNGSQFKKNLEVIISQKPPPDSILCSNAGQTRHQACVNNVPCAGQALRNAVLSNCQDNWKTHVKLAKIIRRTYIGIELVEWLMDHCEFIQNREIASKIWNVLLDLGILLSVEQNNIFEDSRSLYQFTFKECEAQSCDFRNQVNWRSAVHLLLQLVPHEQLCGGTQRRCKEDKQKTPDACNPVLQMRALEHFTSTVQNELLAALARKAQTKSMMEDSNPQHNTDTPGSSSTPAVLKQVPGAGTRDREEISRLEMVQRLAKDGCRLLHSPLRVNERPAEFVECICRGEDWDNVRYRYEMKYMLCGLLLRHLS", "length": 341 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "D3ZJN7-1", "protein_name": "RasGEF domain family, member 1B", "gene_name": "Rasgef1b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPQTPPFSAMFDSSGYNRNVYQPSEDSCGGLNYHDNNLLSGSLEALIQHLVPNVDYYPDRTYIFTFLLSSRLFMHPYELMAKVCHLCIEHQRLSEGDGDKNQTRKIAPKILQLLTEWTETFPYDFRDERMMRNLKDLAHRMASGEETYRKNVQQMMQCLIRKLAALSQYEEVLAKLSSTATDRLTVLKAKPQSIQRDIMTVCSDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLDNDKNCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDPSSNFLNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDIYFLNEGCVNRLPNGHVNFEKFWELAKQVSEFMTWKQVECPFERDRKVLQYLLSVPVFSEDALYLASYESEGPENNIEKDRWKSLRASLLGRV", "length": 472 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZVN9-1", "protein_name": "RasGEF domain family, member 1C", "gene_name": "Rasgef1c", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPRTLTASDMVTPGSLSPPPIDSTEGEQAGQPLLDGAPSSASLETLIQHLVPTADYYPEKAYIFTFLLSSRLFIEPRELLARVCHLCIEQQQLDKPVLDKARVRKFGAKLLQLLAEWTETFPRDFEEESTIGHLTDVVGRISPCDETYGNRMHQLLQTLHQKLASLGQGPEGLVGADKPISYRTKPPASIHRELLGVCSDPYTLAQQLTHVELERLRHIGPEEFVQAFVNKDPLAGTKPRFNDKTNNVEAYVKWFNRLCYLVATEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFFILEHQMDPTGNFCNYRTALRGAAHRSLTAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFLELAKQVGEFITWKQVECPFEQDPSITHYLYTAPIFSEDGLYLASYESESPENQTEKERWKSLRSSILGKT", "length": 466 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E7F7V2-1", "protein_name": "Si:ch211-234p18.3", "gene_name": "rasgrf1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MQKGIRLNDGHVTYLGLLAKKDGTRRGCLSKKSSDNTKWHTKWFALLQNMLFYFESESSSRPSGLYLLEGCVCDRSPSPKPSLSAKECLEKQYYFTVSFNHENQKALELRTEDVKDCDEWVAAISHASYRNLATEHETLMQKYLHLLQIVETEKTVAKQLRQQIEDGEIEIERLKSEIAAMLKDNEKIQSSPTTAPSDDDSEIKKIKKVQSFLRGWMCRRKWKTIIQDYIRSPHAESMRKRNQVVFSMLEAEAEYVQQLHILVNNFLRPLRMAASSKKPPITHDDVSSIFLNSETIMFLHQIFYQGLKARIASWPTLVLADLFDILLPMLNIYQEFVRNHQYSLQILAHCKQNRDFDKLLKQYEAKPDCEERTLETFLTYPMFQIPRYILTLHELLAHTPHEHVERNSLDYAKSKLEELSRIMHDEVSETENIRKNLAIERMIVEGCEILLDTSQTFVRQGSLIQVPMSEKGKITRGRLGSLSLKKEGERQCFLFSKHLIICTRGSGGKLHLTKNGVVSLIDCTLIEEPEGTDDESKSEKSGQDMEHLDFKIVVEPKDSQSFTFILVASSRQEKSAWTSDISQCIDNIRCNGLMMNAFEENSKVTVPQMIKSDASLYCDDVDIRFSKMMNSCKVLQIRYASVERLLERLTDLRFLSIDFLNTFLHSYRVFTSADVVLDKLITIYKRPISAIPARSLELFFASSQNNKLLYGEPPKSPRASRKFSSPPPLAITKTSSPNRRRKLSLNIPIITGGKALDLAALSCSSNGYASMYSTMSPFSKTTLDINKLYVSSPITSKIPDEGEGKTDKADEISLCKQDNSVREESDNDQIQSDEAEAEVSPTKSPTTPKNVKCKNSSEFSLFSYNNGMVMSSCRELDNNRSALSAASAFAIATAGANEGTPTKEKYRRMSLASTGFPTDQRNGDKEFVIRRAATNRVLNVLRHWVSKHSQDFETNTELKMKVISFLEEVMHDPELLTQERKAAANIIRTLTQEDPGDNQICLEEVLQMAEGGKSESFENHSALEIAEQLTLLDHLVFKVIPYEEFFGQGWMKNDKNEKTPYIMKTTKHFNDISDLIATEILRCEDVNVRVAVMEKWVAVADICRCLHNYNAVLEITSSLNRSSIFRLKKTWLKVSKQTKTVIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDNLVNFSKMRMISHIIREIRQFQQTAYKIDYQPKAALYLLDRSAVMEEEGLYEASLRIEPKVPN", "length": 1256 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "F1M386-1", "protein_name": "Rap guanine nucleotide exchange factor 2", "gene_name": "Rapgef2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKPLAAPANHGVLGQQEKQSLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLSDIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFNDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAKRRSMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSSSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEEKRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGGRNKLKKILDKTRISILPQKPYNDIGIGQSQDDSIVGLRQTKHIPAALPVSGTLSSSNPDLLQSHHRILDFSTTPDLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTATPEQYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLKSKTSCANLKKFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLSGQNLQPPVIPLFPVIKKDLTFLHEGNDSKVDGLVNFEKLRMIAKEIRHVGRMASVNMDPALMFRTRKKKWRSLGSLSQGSANATVLDVAQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSNLELEMDEESLQTLSLQCEPATSTLPKNPADRKPVKSETSPVAPRAGPQQKAQPQQPLAPPQPSHKVSQGLQVPAVSLYPSRKKVPVKDLPPFGINSPQALKKILSLSEEGSLERHRKQAEDTISNASSQLSSPPTSPQSSPRKGYALALSGTVDNFSDSGHSEISSRSSIVSNSSFDSVPVSLHDERRQRHSVSIVESNLGVGRMERRTLMEPDQYSLGSYAPVSESRGLYAAATVISSPSTEELSHDQGDRASLDAADSGRGSWTSCSSGSHDNIQTIQHQRSWETLPFGHTHFDYSGDATGIWASGGHMDQIMFSDHSTKYNRQNQSRESLEQAQSRASWASSTGYWGEDSEGDTGTIKRRGGKDVSTEAESSSMVPVTTEEAKPVPMPAHIAVTPSTTKGLIARKEGRYREPPPTPPGYVGIPIADFPEGPCHPARKPPDYNVALQRSRMVARPTEAPAPGQTPPAATASRPGSKPQWHKPSDADPRLAPFQPQGFAGAEEDEDEQVSAV", "length": 1496 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1M8L9-1", "protein_name": "CRK SH3-binding GNRP", "gene_name": "Rapgef1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGNAIEKQKPLRQSHLCPWKQDSQRSHLSSFTMKLMDKFHSPKIKRTPSKKGKPAEVSKTPEKPVSKEARDRFLPEGYPIPLDLEQQAVEFMSTSAVDSRSQRQKNLCWLEEKEKEVVSALRYFKTIVDKMAIDKKVLEMLPGSASKVLEAILPLVQTDPRIQHSSALSSCYSRVYQSLANLIRWSDQVMLEGVNSEDKEMVTTVKGVIKAVLDGVKELVRLTIEKQGRPSPTSPVKPSSPASKPDGQPELPLTEREMEILNKTSVSPSTELLPDSTSEEVAPPKPPLPGIRVVDNSPPALPPKKRQSAPSPTRVAVVAPMSRAVSGSSLPVGINRQDFDVECYTQRRLSGGSRSCGGESPRLSPCSSTGKLSRSDEQLSSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQTPPQAACNLSPLPESMGESGPPFVGYSFQLPLGSCLQQDGQQTDTPPALPEKKRRSAVSQTTDSSGCRVSYERHPSQYDNISEDDLQNPAQPVSYPPFAAILPFQQGASSTPVEFVGDFSVPESAGDPEKPPPLPEKKNKHMLAYMQLLEDYSEPQPSMFYQTPQSEHIYQQKNKMLMEVYGFSDSFCGSDSTQELAPPPALPPKQRQLASYAASSFSVSHCVQQTKVAFTPEDGSAAQGLSVSVSNSFLNRHGSLPVPSYKSVFRSYSQDFMPHHQASVQPFLPPTSSSSPHFPPVHASQSSDLAVPTVSSPPPSTVDGPLSSSQDSSFHGNPVRLPSETSFTDSSENASSEEAGGGEYVNLYSSGQTSEELAPSGGEPPSGKDGHPRDLSVSSASGKDSRENGERSPKSLDALESAQSEEEVDELSLIDHNEIMARLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLVLYCEAFLTTYRTFISPEELIKKLQCRYPSPPKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTEEILKLLMELVFRLVCSGELSLARVLRKNILDKVDQKKLLRCAHSDQPLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSVIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQRQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQFNILDSMRCFQQVHYEIRRNDDIINFFNDFSDHLAEEALWELSLKIKPRNITRRKTDREEKT", "length": 1256 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F6QW76-1", "protein_name": "RAS guanyl releasing protein 3", "gene_name": "RASGRP3", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MGSSGLGKAATLDELLSTCIEMFDDNGELNNSYLPRIVLLMHRWYLSSTELAEKLLCIYRNASGESCDEFRLKICYFMRYWIVKFPAEFNLDLGLIRMTEEFREVASQLGYEKHTSLIDISSIPSYDWMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMMELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNLDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPTKPVVPLEWASGVMPKPDPTVINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFVHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRFARAPSLGSSHGSLPGSPSLPPVQDEVFEFPGVTAGHRDLDSRAITLVTGSSGKISVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMRSKFHDKAAKDKGFAKWENEKPRVQAGVDVVDRGTTFEPDQDEADMDETKQDGEDG", "length": 692 }, "evidence": [ { "id": "A0A0G2KAU4", "url": "https://omabrowser.org/oma/group/A0A0G2KAU4/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "O14827-1", "protein_name": "Ras-specific guanine nucleotide-releasing factor 2", "gene_name": "RASGRF2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQKSVRYNEGHALYLAFLARKEGTKRGFLSKKTAEASRWHEKWFALYQNVLFYFEGEQSCRPAGMYLLEGCSCERTPAPPRAGAGQGGVRDALDKQYYFTVLFGHEGQKPLELRCEEEQDGKEWMEAIHQASYADILIEREVLMQKYIHLVQIVETEKIAANQLRHQLEDQDTEIERLKSEIIALNKTKERMRPYQSNQEDEDPDIKKIKKVQSFMRGWLCRRKWKTIVQDYICSPHAESMRKRNQIVFTMVEAESEYVHQLYILVNGFLRPLRMAASSKKPPISHDDVSSIFLNSETIMFLHEIFHQGLKARIANWPTLILADLFDILLPMLNIYQEFVRNHQYSLQVLANCKQNRDFDKLLKQYEANPACEGRMLETFLTYPMFQIPRYIITLHELLAHTPHEHVERKSLEFAKSKLEELSRVMHDEVSDTENIRKNLAIERMIVEGCDILLDTSQTFIRQGSLIQVPSVERGKLSKVRLGSLSLKKEGERQCFLFTKHFLICTRSSGGKLHLLKTGGVLSLIDCTLIEEPDASDDDSKGSGQVFGHLDFKIVVEPPDAAAFTVVLLAPSRQEKAAWMSDISQCVDNIRCNGLMTIVFEENSKVTVPHMIKSDARLHKDDTDICFSKTLNSCKVPQIRYASVERLLERLTDLRFLSIDFLNTFLHTYRIFTTAAVVLGKLSDIYKRPFTSIPVRSLELFFATSQNNRGEHLVDGKSPRLCRKFSSPPPLAVSRTSSPVRARKLSLTSPLNSKIGALDLTTSSSPTTTTQSPAASPPPHTGQIPLDLSRGLSSPEQSPGTVEENVDNPRVDLCNKLKRSIQKAVLESAPADRAGVESSPAADTTELSPCRSPSTPRHLRYRQPGGQTADNAHCSVSPASAFAIATAAAGHGSPPGFNNTERTCDKEFIIRRTATNRVLNVLRHWVSKHAQDFELNNELKMNVLNLLEEVLRDPDLLPQERKAAANILRALSQDDQDDIHLKLEDIIQMTDCMKAECFESLSAMELAEQITLLDHVIFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNDMSNLVASQIMNYADVSSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTKALMDKLQKTVSSEGRFKNLRETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQTSYRIDHQPKVAQYLLDKDLIIDEDTLYELSLKIEPRLPA", "length": 1237 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "O77086-1", "protein_name": "Guanine nucleotide-releasing factor 2", "gene_name": "C3G", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MPQFDESFLSDCALADRWHFYSYTVKQLPPHPSPKPNRNRNPYPSGASHDDHQHQLHHHHHQQHHHNHHRLWKTQRQSWSPRDTNNNHSLTSNNCNCNSSNTCNSISATGNTLHSIKFHRRRKYKKLARLALSTPAIPLQMDVDVDVNVTVDREFDMEMDTPVPLKNAVCHGSISSPSTPGTCSSGIGVGGGGCSSSSNNSINSGSYSTACTPPPPTHQHHSQHQQLQGTPGGSSRVGGAGAGGGGGVPPAPPSAGSSGHKNSLKGTKLARRARSFKDDLIEKISLMRTTNNTLGRSHSPHSPRTKHGTKAPPTTEEVLRSTQTLETHVKDISNALKHFRDVILKKKLEVLPGNGTVILETIASMYSVIQTYTLNENSAIMSSATLQVYQSLGKLIKLCDEVMLSEDSGECASLSNENVREVIDLLEDAVRNLVTLAQGKLKEQDQCAFRYSGSGLGGIGAAAEIMGAVTASPGASVPGTGVMRVSAAESAAQRTSLPDIALTPKERDILEQHNVNPMRGSHSTESILRDTSPPPKPPLPNRASNPPPLPPKRRSQPSASAGTVGVGCSSSTSTSNQASPLPYAQSHNISLNSDLDCSSNISLLNYGVDRLSVRSRSPDENSQCSFDSALNHSREEEDQQQQHQHLRSFPKLAAMMDEDMDKMVSYSAAIDDKTQTPLSTGGGIAGVAGGTGGAGEGVAAAASGDGETNSNRHSNESGFVSMREFRTSTQTTDYSVQSSTKSSSSNSEIAFSISESTAVGSSSEYQQISQLVSHSQRHISSSSSSCTTTTTSSSTTTGYGSSEVEQLQQQQQQQTTTTPADLAPALPPKSIQRSSLTRHDSPGVGDELDEVQSSSGWASHRSSQSEVAELRQLSPLHHLNHHPHTASAGQLQQWHSKHHSLIEGPRLQLAGSGSCSAFDQRHLDQEPPPLPIKKKHILAYMEICSASTRSIEQHRHTMHACNISRNISHSQTMNIMPMSKELSPELEMPPALPPKNYKQRKATSMVASPTLQPVIVTTPPPSPKPTLGENGSTGRPDSRMATVCEELNDAVASEDAMPEPRSPVLDSNENVSAVDDGQTFYCHSHQLPAAEMEMSEDASSADNQPITTPQVLEEQEEPTAESRPLVAVHESVKPANVDEDEEAERADMLINMLEEVNITRYLILKKREEDGPEVKGGYIDALIVHASRVQKVADNAFCEAFITTFRTFIQPIDVIEKLTHRYTYFFCQVQDNKQKAAKETFALLVRVVNDLTSTDLTSQLLSLLVEFVYQLVCSGQLYLAKLLRNKFVEKVTLYKEPKVYGFVGELGGAGSVGGAGIAGSGGCSGTAGGGNQPSLLDLKSLEIAEQMTLLDAELFTKIEIPEVLLFAKDQCEEKSPNLNKFTEHFNKMSYWARSKILRLQDAKEREKHVNKFIKIMKHLRKMNNYNSYLALLSALDSGPIRRLEWQKGITEEVRSFCALIDSSSSFRAYRQALAETNPPCIPYIGLILQDLTFVHVGNQDYLSKGVINFSKRWQQYNIIDNMKRFKKCAYPFRRNERIIRFFDNFKDFMGEEEMWQISEKIKPRGRRPVNY", "length": 1571 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "O95267-1", "protein_name": "RAS guanyl-releasing protein 1", "gene_name": "RASGRP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGTLGKAREAPRKPSHGCRAASKARLEAKPANSPFPSHPSLAHITQFRMMVSLGHLAKGASLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVISSAELLQKVITLYKDALAKNSPGLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELVKAKGEELHCRLIDTTQINARDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKVNVHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPRNHRAPPLTPSKPPVVVDWASGVSPKPDPKTISKHVQRMVDSVFKNYDHDQDGYISQEEFEKIAASFPFSFCVMDKDREGLISRDEITAYFMRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKRAKNPVAPTENNTSVGPVSNLCSLGAKDLLHAPEEGPFTFPNGEAVEHGEESKDRTIMLMGVSSQKISLRLKRAVAHKATQTESQPWIGSEGPSGPFVLSSPRKTAQDTLYVLPSPTSPCPSPVLVRKRAFVKWENKDSLIKSKEELRHLRLPTYQELEQEINTLKADNDALKIQLKYAQKKIESLQLEKSNHVLAQMEQGDCS", "length": 797 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P07866-1", "protein_name": "Guanine nucleotide exchange factor LTE1", "gene_name": "LTE1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MEIFSQKDYYPTPSSNVISYESDCVSKPVNSADLPALIVHLSSPLEGVDYNASADFFLIYRNFITPQDLHDLLIYRFRWCIREITTNAAKAKRRRIGEVALVRTFVLLRHSILNYFVQDFLPNITLRLRLIEFLNDKHIEQYPKIISSCIINLKKNWVHCSKLVWENIELNEPDKLDFDAWLHYSLKDFTQLESLHKRGSRLSIYARQSFASPDFRNQSVLSLYKTSDVFRLPEKLQSSNSSKNQRSPSMLLFPDNTSNVYSKHRIAKEPSVDNESEDMSDSKQKISHLSKVTLVSTLMKGVDYPSSYAVDKIMPPTPAKKVEFILNSLYIPEDLNEQSGTLQGTSTTSSLDNNSNSNSRSNTSSMSVLHRSAIGLLAKWMKNHNRHDSSNDKKFMSAIKPANQKPEMDAFVKYVVSISSLNRKSSKEEEEEFLNSDSSKFDILSARTIDEVESLLHLQNQLIEKVQTHSNNNRGPTVNVDCERREHIHDIKILQQNSFKPSNDNFSAMDNLDLYQTVSSIAQSVISLTNTLNKQLQNNESNMQPSPSYDALQRRKVKSLTTAYYNKMHGSYSAESMRLFDKDNSSSRTDENGPQRLLFHETDKTNSEAITNMTPRRKNHSQSQKSMTSSPLKNVLPDLKESSPLNDSREDTESITYSYDSELSSSSPPRDTVTKKSRKVRNIVNNTDSPTLKTKTGFLNLREFTFEDTKSLDEKKSTIDGLEKNYDNKENQESEYESTKKLDNSLDASSEANNYDITTRKKHSSCNHKIKQAVVRPASGRISISRVQSIAITPTKELSIVDPEQNKSNSVIEEISEIEPLNLEYNKKSALYSDTSSTVISISTSKLFESAQNSPLKQTQNPQREFPNGTSVSETNRIRLSIAPTIESVVSDLNSITTGSTVETFETSRDLPVPHQRIINLREEYQRGNQDIISNTSSLHELKTIDLSDSNNDLESPSTHAKNNKYFFSPDDGSIDVASPMKNVEELKSKFLKNESETNSNISGSVLTMDDIDINDTSSARNTRRANSESAFTGSLNKKNLNEIANMLDDSINDDPITVALMKLEGTYEKIPEKPENTKSSDAIGIKTSKLADEVEMLNLNNLPSFQNSPAEKRKSLLIERRRQTIMNIPFTPDQSEKEGFTSSSPEKIDVSANVDVAVQAAQIQELIGQYRIHDSRLMISNNESHVPFILMYDSLSVAQQMTLIEKEILGEIDWKDLLDLKMKHEGPQVISWLQLLVRNETLSGIDLAISRFNLTVDWIISEILLTKSSKMKRNVIQRFIHVADHCRTFQNFNTLMEIILALSSSVVQKFTDAWRLIEPGDLLTWEELKKIPSLDRNYSTIRNLLNSVNPLVGCVPFIVVYLSDLSANAEKKDWILEDKVVNYNKFDTNVQIVKNFIQRVQWSKFYTFKVNHELLSKCVYISTLTQEEINELST", "length": 1435 }, "evidence": [ { "id": "RGD:1304612", "url": "https://alliancegenome.org/gene/RGD:1304612#orthology", "database": "AGR" }, { "id": "MGI:3028579", "url": "https://alliancegenome.org/gene/MGI:3028579#orthology", "database": "AGR" }, { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-070424-82", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-070424-82#orthology", "database": "AGR" }, { "id": "HGNC:14545", "url": "https://alliancegenome.org/gene/HGNC:14545#orthology", "database": "AGR" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "P0C643-1", "protein_name": "RAS guanyl-releasing protein 2", "gene_name": "Rasgrp2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASTLDLDKGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHPWYIPSSQLASKLLHFYQQSRKDNSNSLQVKTCHLVRYWVSAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDIESVPTYKWKRQVTQRNPVEQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCTVDNPVLERFISLFNSVSQWVQLMILSKPTATQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSPDTIKLWEGLTELVTATGNYSNYRRRLAACVGFRFPILGVHLKDLVALQLALPDWLDPGRTRLNGAKMRQLFSILEELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQREPRSKSSPTSPTSCTPPPRPPVLEEWTSVAKPKLDQALVAEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISREEMISYFLRSSSVLGGRMGFVHNLQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQCKDRLSVECRRRAQSVSLEGSAPSPSPTHTHHRAFSFSLPRPGRRSSRPPEIREEEVQTVEDGVFDIHL", "length": 608 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P27671-1", "protein_name": "Ras-specific guanine nucleotide-releasing factor 1", "gene_name": "Rasgrf1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQKAIRLNDGHVVTLGLLAQKDGTRKGYLSKRSADNPKWQTKWFALLQNLLFYFESDSSPRPSGLYLLEGSICKRAPSPKRGTSSKESGEKQQHYFTVNFSNDSQKTLELRTEDAKDCDEWVAAIARASYKILATEHEALMQKYLHLLQVVETEKTVAKQLRQQLEDGEVEIERLKTEVTITNLIKDNDRIQSSNKAGSADDEDSDIKKIKKVQSFLRGWLCRRKWKNIIQDYIRSPHADSMRKRNQVVFSMLEAEAEYVQQLHILVNNFLRPLRMAASSKKPPITHDDVSSIFLNSETIMFLHQIFYQGLKARISSWPTLVLADLFDILLPMLNIYQEFVRNHQYSLQILAHCKQNRDFDKLLKQYEAKPDCEERTLETFLTYPMFQIPRYILTLHELLAHTPHEHVERNSLDYAKSKLEELSRIMHDEVSETENIRKNLAIERMITEGCEILLDTSQTFVRQGSLMQMSLSEKSKSSRGRLGSLSTKKEGERQCFLFSKHLIICTRGSGGKLHLTKNGVISLIDCTLLDEPENLDDEAKGAGPEIEHLEFKIGVEPKDSLPFTVILVASTRQEKAAWTSDIIQCVDNIRCNGLMMNAFEENSKVTVPQMIKSDASLYCDDVDIRFSKTMNSCKVLQIRYASVERLLERLTDLRFLSIDFLNTFLHSYRVFTNAMVVLDKLINIYRKPMSAIPARSLELLFSSSHNAKLLYGDAPKSPRASRKFSSPPPLAIGTSSPSRRRKLSLNIPIITGGKALELASLGCSSDSYANIHSPISPFGKTTLDTGKLCMASSLPKTPEEIDVPATIPEKPGELSASRKHSSDVLKEESEDDQNHSDEDNTEVSPVKSPPTPKSFLNRTITEFPFFNYNNGILMTTCRDLVDNNRSTLSATSAFAIATAGANEGPSNKEVFRRMSLANTGFSSDQRNIDKEFVIRRAATNRVLNVLRHWVTKHTQDFDTDDTLKYRVICFLEEVMHDPDLLTQERKAAANIIRTLTLEETTEQHSMLEEVILMTEGVKTEPFENHPALEIAEQLTLLDHLVFKSIPYEEFFGQGWMKAEKYERTPYIMKTTKHFNHVSNFIASEIIRNEDISARASAIEKWVAVADICRCLHNYNAVLEITSSINRSAIFRLKKTWLKVSKQTKSLLDKLQKLVSSDGRFKNLRESLRNCDPPCVPYLGMYLTDLVFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTTYKIDPQPKVIQYLLDESFMLDEESLYESSLLIEPKLPT", "length": 1262 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P28818-1", "protein_name": "Ras-specific guanine nucleotide-releasing factor 1", "gene_name": "Rasgrf1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQKAIRLNDGHVVSLGLLAQRDGTRKGYLSKRSSDNPKWQTKWFALLQNLLFYFESDSSSRPSGLYLLEGSICKRMPSPKRGTSSKESDKQHHYFTVNFSNDSQKSLELRTDDSKDCDEWVAAIARASYKILATEHEALMQKYLHLLQVVETEKTVAKQLRQQLEDGEVEIERLKAEIANLIKDNERIQSNQLVAPEDEDSDIKKIKKVQSFLRGWLCRRKWKNIIQDYIRSPHADSMRKRNQVVFSMLEAEAEYVQQLHILVNNFLRPLRMAASSKKPPITHDDVSSIFLNSETIMFLHQIFYQGLKARIASWPTLVLADLFDILLPMLNIYQEFVRNHQYSLQILAHCKQNRDFDKLLKQYEAKPDCEERTLETFLTYPMFQIPRYILTLHELLAHTPHEHVERNSLDYAKSKLEELSRVMHDEVSETENIRKNLAIERMITEGCEILLDTSQTFVRQGSLIQVPMSEKGKINKGRLGSLSLKKEGERQCFLFSKHLIICTRGSGSKLHLTKNGVISLIDCTLLDDPENMDDDGKGQEVDHLDFKIWVEPKDSPPFTVILVASSRQEKAAWTSDIIQCVDNIRCNGLMMNAFEENSKVTVPQMIKSDASLYCDDVDIRFSKTMNSCKVLQIRYASVERLLERLTDLRFLSIDFLNTFLHSYRVFTDAVVVLDKLISIYKKPITAIPARSLELLFSSSHNTKLLYGDAPKSPRASRKFSSPPPLAIGTSSPVRRRKLSLNIPIITGGKALELASLGCPSDGYTNIHSPISPFGKTTLDTSKLCVASSLTRTPEEIDMTTLEESSGFRKPTSDILKEESDDDQSDVDDTEVSPPTPKSFRNRITQEFPLFNYNSGIMMTCRDLMDSNRSPLSATSAFAIATAGANESPANKEIYRRMSLANTGYSSDQRNIDKEFVIRRAATNRVLNVLRHWVTKHSQDFETDDLLKYKVICFLEEVMHDPDLLPQERKAAANIMRTLTQEEITENHSMLDELLLMTEGVKTEPFENHSAMEIAEQLTLLDHLVFKSIPYEEFFGQGWMKADKNERTPYIMKTTRHFNHISNLIASEILRNEEVSARASTIEKWVAVADICRCLHNYNAVLEITSSINRSAIFRLKKTWLKVSKQTKSLFDKLQKLVSSDGRFKNLRETLRNCDPPCVPYLGMYLTDLAFLEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTTYKIEPQPKVTQYLVDETFVLDDESLYEASLRIEPKLPT", "length": 1244 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P70392-1", "protein_name": "Ras-specific guanine nucleotide-releasing factor 2", "gene_name": "Rasgrf2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQKSVRYNEGHALYLAMLARKEGTKRGFLSKKAAEASRWHEKWFALYQNVLFYFEGEQSGRPAGMYLLEGCSCERTPAPPRTNAGPAGARDALDKQYYFTVLFGHDGQKPLELRCEEEQAGKEWMEAIHQASYADILIEREVLMQKYIHLVQIVETEKIATNQLRHQLEDQDTEIERLKSEIVALNKTKERMRPYHVHQEEEDPDIKKIKKVQSFMRGWLCRRKWKTIVQDYICSPHAESMRKRNQIVFTMVEAETEYVHQLYILVNGFLRPLRMAASSKKPPINHDDVSSIFLNSETIMFLHEIFHQGLKARLANWPTLVLADLFDILLPMLNIYQEFVRNHQYSLQVLANCKQNRDFDKLLKQYEANPACEGRMLETFLTYPMFQIPRYIITLHELLAHTPHEHVERKSLEFAKSKLEELSRVMHDEVSDTENIRKNLAIERMIVEGCDILLDTSQTFIRQGSLIQVPSVERGKLSKVRLGSLSLKKEGERQCFLFTKHFLICTRSSGGKLHLLKTGGVLSLIQCTLIEEPDGSDDDPKGSGHMFGHLDFKIVVEPPDAASFTVVLLAPSRQEKAAWMSDISQCVDNIRCNGLMTIVFEENSKVTVPHMIKSDARLHKDDTDICFSKTLNSCKVPQIRYASVERLLERLTDLRFLSIDFLNTFLHTYRIFTTATVVLAKLSDIYKRPFTSIPVRSLELFFATSQNNREHLVDGKSPRLCRKFSSPPPLAVSRTSSPVRARKLSLTSSLNSRIGALDLTNSSSSSSPTTTTHSPAASPPPHTAVLESAPADKAGDSADMSPCRSPTTPRHLRYRQPGGQVADSAHCSVSPASAFAIATAAAGHGSPPGFNNERTCDKEFIIRRTATNRVLNVLRHWVSKHAQDFELNNELKMNVLNLLEEVLRDPDLLPQERKATANILRALSQDDQDDIHLKLEDIIQMTDCPKAECFETLSAMELAEQITLLDHIVFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNEMSNLVASQIMNYADISSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTKALMDKLQKTVSSEGRFKNLRETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQTAYRIDQQPKVIQYLLDKALVIDEDSLYELSLKIEPRLPA", "length": 1189 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q13905-1", "protein_name": "Rap guanine nucleotide exchange factor 1", "gene_name": "RAPGEF1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDTDSQRSHLSSFTMKLMDKFHSPKIKRTPSKKGKPAEVSVKIPEKPVNKEATDRFLPEGYPLPLDLEQQAVEFMSTSAVASRSQRQKNLSWLEEKEKEVVSALRYFKTIVDKMAIDKKVLEMLPGSASKVLEAILPLVQNDPRIQHSSALSSCYSRVYQSLANLIRWSDQVMLEGVNSEDKEMVTTVKGVIKAVLDGVKELVRLTIEKQGRPSPTSPVKPSSPASKPDGPAELPLTDREVEILNKTTGMSQSTELLPDATDEEVAPPKPPLPGIRVVDNSPPPALPPKKRQSAPSPTRVAVVAPMSRATSGSSLPVGINRQDFDVDCYAQRRLSGGSHSYGGESPRLSPCSSIGKLSKSDEQLSSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQIPQQTAWNLSPLPESLGESGSPFLGPPFQLPLGGHPQPDGPLAPGQQTDTPPALPEKKRRSAASQTADGSGCRVSYERHPSQYDNISGEDLQSTAPIPSVPYAPFAAILPFQHGGSSAPVEFVGDFTAPESTGDPEKPPPLPEKKNKHMLAYMQLLEDYSEPQPSMFYQTPQNEHIYQQKNKLLMEVYGFSDSFSGVDSVQELAPPPALPPKQRQLEPPAGKDGHPRDPSAVSGVPGKDSRDGSERAPKSPDALESAQSEEEVDELSLIDHNEIMSRLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLVLYCEAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTEEILKLLMELVFRLVCNGELSLARVLRKNILDKVDQKKLLRCATSSQPLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQKQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQFNILDSMRCFQQAHYDMRRNDDIINFFNDFSDHLAEEALWELSLKIKPRNITRRKTDREEKT", "length": 1077 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q13972-1", "protein_name": "Ras-specific guanine nucleotide-releasing factor 1", "gene_name": "RASGRF1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQKGIRLNDGHVASLGLLARKDGTRKGYLSKRSSDNTKWQTKWFALLQNLLFYFESDSSSRPSGLYLLEGCVCDRAPSPKPALSAKEPLEKQHYFTVNFSHENQKALELRTEDAKDCDEWVAAIAHASYRTLATEHEALMQKYLHLLQIVETEKTVAKQLRQQIEDGEIEIERLKAEITSLLKDNERIQSTQTVAPNDEDSDIKKIKKVQSFLRGWLCRRKWKTIIQDYIRSPHADSMRKRNQVVFSMLEAEAEYVQQLHILVNNFLRPLRMAASSKKPPITHDDVSSIFLNSETIMFLHQIFYQGLKARISSWPTLVLADLFDILLPMLNIYQEFVRNHQYSLQILAHCKQNRDFDKLLKHYEAKPDCEERTLETFLTYPMFQIPRYILTLHELLAHTPHEHVERNSLDYAKSKLEELSRIMHDEVSETENIRKNLAIERMIIEGCEILLDTSQTFVRQGSLIQVPMSEKGKITRGRLGSLSLKKEGERQCFLFSKHLIICTRGSGGKLHLTKNGVISLIDCTLLEEPESTEEEAKGSGQDIDHLDFKIGVEPKDSPPFTVILVASSRQEKAAWTSDISQCVDNIRCNGLMMNAFEENSKVTVPQMIKRTREGTREAEMSRSDASLYCDDVDIRFSKTMNSCKVLQIRYASVERLLERLTDLRFLSIDFLNTFLHSYRVFTTAIVVLDKLITIYKKPISAIPARWLRSLELLFASGQNNKLLYGEPPKSPRATRKFSSPPPLSITKTSSPSRRRKLSLNIPIITGGKALDLAALSCNSNGYTSMYSAMSPFSKATLDTSKLYVSSSFTNKIPDEGDTTPEKPEDPSALSKQSSEVSMREESDIDQNQSDDGDTETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVVMTSCRELDNNRSALSAASAFAIATAGANEGTPNKEKYRRMSLASAGFPPDQRNGDKEFVIRRAATNRVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDPGDNQITLEEITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEESLYESSLRIEPKLPT", "length": 1273 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5NCJ0-1", "protein_name": "Rap guanine nucleotide exchange factor (GEF) 6", "gene_name": "Rapgef6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNSPVDPGARQALRKKPPERTPEDLNIIYSYLHGMEILSNLREHQLRLMSTRARYERYSGNQMLFCSETIARCWYILLSGSVLVKDSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVVENSKDNEDSILQREIPARQSRRRFRKINYKGERQTIIDGVDINNYLSLPADLTKMHLTDNPHPQVTHVSSSQSGCSIASDSGSSSLSDIYQATESEVGDVDLTRLPEGPVDSEDEEEEEEEIDRTDPLQGRDLVRECLEKEPADKTDDDVEQLLEFMHQLPAFANMTMSVRRELCSVMVFEVVEQAGAVILEDGQELDSWYVILNGTVEISHPDGKIENLFMGNSFGIVPTLDKQHMHGAVRTKVDDCQFVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVHEHRELDRSGTRKGHIVIKATPERLIMHLIEEHSIVDPTYIEDFLLTYRTFLETPLDVGIKLLEWFKIDNLRDKVTRIVLLWVNNHFNDFEGDPAMTQFLEEFERNLEDTKMNGHLRLLNIACAAKAKWRQVVLQKASRESPLHFCLTGGSEKGFGVFVEEVESGSKAADAGLKRGDQVMEVNGQNFENITLAKALEILRNNTHLALTVKTNIFVFKELLSRTEQEKSGVPHIPKIAEKKSNRHSIQDVPGDMEQAPQEKGNKKIKANTVSGGRNKIRKILDKTRFSILPPKLFSDGGLSQSQDDSIVGTRHCRHSLAIMPIPGTLSSSSPDLLQPTTSMLDFSNPSDIPDQVIRVFKADQQSCYIIISKDTTAKEVVCQAVQEFGLTGASDTYSLCEVSVTPEGVIKQRRLPDQFSKLADRIQLNGRYYLKNNMETETLCSDEDAQELLKESQLSMLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKLDSKTGNTHLKQFEDIVNQETFWVASEILSESNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRGTWEKLPSKYEKHLQDLQDLFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFLHEGNDSKVDGLVNFEKLRMIAKEIRHIIRMTSANMDPAMMFRQRSLSQGSTNSNMLDVQGGAHKKRARRSSLLNAKKLYEDAQMARKVKQYLSSLDIDTDEEKFQMMSLQWEPAYGTLTKNLTEKRSAKSSEMSPVPLRSVGQTAKVHLHQPHRVSQVLQVPAVNLHPIRKKGQAKDHVLSTSLPQKGLGPTEEVSVKKHTEDTISVASSLHSSPPASPQNSPRKGYTLTPSSKCDNLSDSSHSEISSRSSIVSNGSVDSMSAAGQDERCSSHSLAVPEPTGALEKTDHPSGISDHSQLAHGWMLSKPCLIKGVAVSSSLSSEEMSHEHVVLEAADSGRGSWTSCSSSSHDNFQSLQNQKSWDFLNSYRHMHLDDPIAEVEPTDCEPCACPKGCSRTCGQCKGSLETNQLRQSWASSSSLSDTCEPNYGTVKRRVLESAPAEAPDGLEPRDTTDPVYKTVTSSTDKGLIVYCVTSPKKGDRYREPPPTPPGYLGISLADLKEGPHPHLKPPDYSVAVQRSKMMLNSLSRLPPAPPSSHTSAWVPSKIGSQPQRHSHPKLADVADADSEADENEQVSAV", "length": 1601 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6DBW1-1", "protein_name": "Ras-GEF domain-containing family member 1B-B", "gene_name": "rasgef1bb", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MPQTTPYSSKFNPSAYSSSHSHRQPVEENYGGLHYRDNKLVSGSLEALIQLLVPTVDYYPDRSYIFTFLLSSRLFLNPFELMSRVCYLGVDHHRVGDPQMDKKRIRDIAPKIVQLLTEWTETFPYDFRDERMMRSLKEMTHRLAFGDELSRRAMQRLIQRLLRKLTTLGQYEESLATTSAAAAIDRPVALKSKQQLVRRDDCVLNLCDDPFIFAQQLTHIEMERLSYIGPEEFVRAFAQKRPSDNHKSFFSKRKASNLEAYVEWFNRLSYLTATEICMPVKKKHRARVLEFFIDVAQECFNIGNFNSLMAIITGMNMNPVSRLKKTWGKVNTDKFDILVHQMDPSSNFYSYRTALRGATQRSSTAHTSQEMIVIPFFSLFIKDIYFLNEGCANRLSNGHINFEKFWELAKQVSEFLSWRQVICPFERDRKTLQYLISAPVFSEDELQLASYESEGPENNLERDTRRSLRSSLSRM", "length": 475 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q6DHR3-1", "protein_name": "Ras-GEF domain-containing family member 1B-A", "gene_name": "rasgef1ba", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MAKFLAELLGCTLPEKGASPMFECRSQPHIGLRHVTKQRDKMPQTPPFPVMYGSTNGYNKNLYKAKEEDYEGLYYHDNNLISGSLEALIEHLVPTVAYYPDRTYIFTFLLSSRLFLHPYELMSKVCHLCVDQQRLSDPQADKARVRKIAPKILQLLTEWTETFPYDFRDERMMKSLKELTHRLSTGEDLYRKAVQQMTQTLIRKLTTLSQYEEALAKINSSVTDRLTVLKTKPQSIQRDILTICNDPFTLAQQLTHIELERLSYIGPEEFVQAFVQKDPLDNDKNCFSDHKKASNLEAYVEWFNRLSYLVATEICMPVKKKHRARVIEFFIDVARECFNIGNFNSLMAIITGMNMSPVSRLKKTWAKVKTAKFDILEHQMDPSSNFYNYRTALRGATQRSITAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVTEFMTWKKVECPFDRDRKILQYLLTAPVFSEDALYLASYESEGPENNMEKDRWKSLRSSLLNRT", "length": 514 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q6NZH9-1", "protein_name": "RAS, guanyl releasing protein 3", "gene_name": "Rasgrp3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGSNGLGKAATLDELLSTCIEMFDDNGDLNDSYLPRIVLLMHRWYLSSTELAGKLLCMYRNASGESCDEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGHEKHISLMDISSVPSYDWMRRVTQRKKVSKRGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSKPSAQQRAEVITKFINVAQKLLQLKNFNTLMAVVGGLSHSSISRLKDTHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWMEENKVNVVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWASEVVPKPDPTIINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMNYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRLARAPSLSSNPGSLPGSPALPPVQDEVFEFPGVTAGHRDLDSRAITLVTGSSRKISVRLQRATTSQATQTEPVWSEAVWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPTVQAGVDVVDRGTAFEPDQDDGQDEAKQGGEDG", "length": 691 }, "evidence": [ { "id": "RGD:1304612", "url": "https://alliancegenome.org/gene/RGD:1304612#orthology", "database": "AGR" }, { "id": "MGI:3028579", "url": "https://alliancegenome.org/gene/MGI:3028579#orthology", "database": "AGR" }, { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-070424-82", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-070424-82#orthology", "database": "AGR" }, { "id": "HGNC:14545", "url": "https://alliancegenome.org/gene/HGNC:14545#orthology", "database": "AGR" }, { "id": "A0A0G2KAU4", "url": "https://omabrowser.org/oma/group/A0A0G2KAU4/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q7LDG7-1", "protein_name": "RAS guanyl-releasing protein 2", "gene_name": "RASGRP2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGTLDLDKGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRKDNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDIDSVPTYKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQREPRSKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQALVVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISREEMVSYFLRSSSVLGGRMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQCKDRLSVECRRRAQSVSLEGSAPSPSPMHSHHHRAFSFSLPRPGRRGSRPPEIREEEVQTVEDGVFDIHL", "length": 609 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BTM9-1", "protein_name": "RAS guanyl-releasing protein 4", "gene_name": "Rasgrp4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNRKDIKRKSHQECSGKAGGRGRSRQARRHKTCPTPREISKVMASMNLGVLSESSCSEDELLEECIRCFDSAGSLRRGDHILKMVLTMHSWVLPSSELAARLLTSYQKAAKDAQELRQLQICYLVRYWLTHHHEAVHQEPQLEAVISRFWTTVAQEGNMAQRSLGDASSLLSPGGPGPPPPMSSPGLGKKRKVSLLFDHLETEELAQHLTYLEFRSFQAITPQDLRGYVLQGSVRGCPALEGSVGLSNSVSRWVQVMVLSRPGPAQRAQVLDKFIRVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHVHLSPDSTKALLELTELLSSHNNYAHYRRTWAGCTGFRLPVLGVHLKDLVSLYEAHPDRLPDGRLHLPKLNSLYLRLQELMALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFKAPVVVEWAQGVTPKPDSVTLGQHVEQLVESVFKNYDPEGRGSISLEDFERLSGNFPFACHGLHPPPRHGSGSFSREELTKYLLHASAICSKLGLAFLHAFQEVTFRKPTFCHSCSGFLWGVTKQGYRCRDCGLCCHRHCRDQVRVECKKRPETKGDPGPPGAPVPATSLPPANCGSEESLSYTLSPDPESGCHLRHAWTQTESSHSSWEPEVVPCPARVLPSRASSKPSV", "length": 673 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8CHG7-1", "protein_name": "Rap guanine nucleotide exchange factor 2", "gene_name": "Rapgef2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKPLAAPANHGVLGQQEKQSLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLSDIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFNDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAKRRLMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSCSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEEKRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGGRNKLKKILDKTRISILPQKPYNDIGIGQSQDDSIVGLRQTKHIPAALPVSGTLSSSNPDLLQSHHRILDFSTTPDLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTATPEQYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLKSKTSCANLKKFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLSGQNLQPPVIPLFPVIKKDLTFLHEGNDSKVDGLVNFEKLRMIAKEIRHVGRMASVNMDPALMFRTRKKKWRSLGSLSQGSANATVLDVAQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSNLELEMDEESLQTLSLQCEPATSTLPKNPGDKKPVKSETSPVAPRAGPQQKVQPQQPLAQPQPPHKVSQGLQVPAVSLYPSRKKVPVKDLPPFGINSPQALKKILSLSEEGSLERHRKQAEDTISNASSQLSSPPTSPQSSPRKGYALALSGTVDNFSDSGHSEISSRSSIVSNSSFDSVPVSLHDERRQRHSVSIVESNLGVGRMERRTLMEPDQYSLGSYAPVSESRGLYAAATVISSPSTEELSHDQGDRASLDAADSGRGSWTSCSSGSHDNIQTIQHQRSWETLPFGHTHFDYSGDAASIWASGGHMDQMMFSDHSTKYNRQNQSRESLEQAQSRASWASSTGYWGEDSEGDTGTIKRRGGKDVSAEAESSSMVPVTTEEAKPVPMPAHIAVTPSTTKGLIARKEGRYREPPPTPPGYVGIPIADFPEGPCHPARKPPDYNVALQRSRMVARPTEAPAPGQTPPAAAASRPGSKPQWHKPSDADPRLAPFQPQGFAGAEEDEDEQVSAV", "length": 1496 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IV61-1", "protein_name": "Ras guanyl-releasing protein 3", "gene_name": "RASGRP3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYRNATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSIPSYDWMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWALGVMPKPDPTVINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHRDLDSRAITLVTGSSRKISVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPRVHAGVDVVDRGTEFELDQDEGEETRQDGEDG", "length": 690 }, "evidence": [ { "id": "RGD:1304612", "url": "https://alliancegenome.org/gene/RGD:1304612#orthology", "database": "AGR" }, { "id": "MGI:3028579", "url": "https://alliancegenome.org/gene/MGI:3028579#orthology", "database": "AGR" }, { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-070424-82", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-070424-82#orthology", "database": "AGR" }, { "id": "HGNC:14545", "url": "https://alliancegenome.org/gene/HGNC:14545#orthology", "database": "AGR" }, { "id": "A0A0G2KAU4", "url": "https://omabrowser.org/oma/group/A0A0G2KAU4/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8JZL7-1", "protein_name": "Ras-GEF domain-containing family member 1B", "gene_name": "Rasgef1b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPQTPPFSAMFDSSGYNRNLYQSAEDSCGGLYYHDNNLLSGSLEALIQHLVPNVDYYPDRTYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSEGDGDKNQMRKIAPKILQLLTEWTETFPYDFRDERMMRNLKDLAHRMASGEEQTYRKNVQQMMQCLIRKLAALSQYEEVLAKLSSTATDRLTVLKTKPQSIQRDIMTVCSDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDPSSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDIYFLNEGCVNRLPNGHVNFEKFWELAKQVSEFMTWKQVECPFERDRKVLQYLLSVPVFSEDALYLASYESEGPENNIEKDRWKSLRSSLLGRV", "length": 473 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N431-1", "protein_name": "Ras-GEF domain-containing family member 1C", "gene_name": "RASGEF1C", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPQTLSASDMVTPGSLSPPPTEPTDGEQAGQPLLDGAPSSASLETLIQHLVPTADYYPEKAYIFTFLLSSRLFIEPRELLARVCHLCIEQQQLDKPVLDKARVRKFGPKLLQLLAEWTETFPRDFQEESTIGHLKDVVGRIAPCDEAYRKRMHQLLQALHQKLAALRQGPEGLVGADKPISYRTKPPASIHRELLGVCSDPYTLAQQLTHVELERLRHIGPEEFVQAFVNKDPLASTKPCFSDKTSNLEAYVKWFNRLCYLVATEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVRTAKFFILEHQMDPTGNFCNYRTALRGAAHRSLTAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFLELAKQVGEFITWKQVECPFEQDASITHYLYTAPIFSEDGLYLASYESESPENQTEKERWKALRSSILGKT", "length": 466 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8N9B8-1", "protein_name": "Ras-GEF domain-containing family member 1A", "gene_name": "RASGEF1A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPQTSVVFSSILGPSCSGQVQPGMGERGGGAGGGSGDLIFQDGHLISGSLEALMEHLVPTVDYYPDRTYIFTFLLSSRVFMPPHDLLARVGQICVEQKQQLEAGPEKAKLKSFSAKIVQLLKEWTEAFPYDFQDEKAMAELKAITHRVTQCDEENGTVKKAIAQMTQSLLLSLAARSQLQELREKLRPPAVDKGPILKTKPPAAQKDILGVCCDPLVLAQQLTHIELDRVSSIYPEDLMQIVSHMDSLDNHRCRGDLTKTYSLEAYDNWFNCLSMLVATEVCRVVKKKHRTRMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKVKTAKFDVLEHHMDPSSNFCNYRTALQGATQRSQMANSSREKIVIPVFNLFVKDIYFLHKIHTNHLPNGHINFKKFWEISRQIHEFMTWTQVECPFEKDKKIQSYLLTAPIYSEEALFVASFESEGPENHMEKDSWKTLRTTLLNRA", "length": 481 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8R5I4-1", "protein_name": "RAS guanyl-releasing protein 4", "gene_name": "Rasgrp4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNRKDIKRKSHQECSGKAGGHGRPRQARRHKTCPTPREISKVMASLNLGVLSESSCSVDELLEECIRCFDSAGSLHRGDHILKMVLTMHSWVLPSSDLAARLLTSYQKAAKDARELRQLQICYLVRYWLTHHPEVVHQEPQLEAIINRFWTTVAQEGNMAQRSLGDASNLLSPGGPGPPPLMSSPGLGKKRKVSLLFDHLETEELAQHLTYLEFRSFQAITPQDLRGYVLQGSVRGCPALEGSVGLSNSVSRWVQVMVLSRPGPAQRAQVLDKFIRVAQRLRQMQNFNTLMAVTGGLCHSAISRLKDSHVHLSPDSTKALLELTELLSSHNNYAYYRRTWASCTDFRLPVLGVHLKDLVSLYEAHPDRLPDGRLHLPKLNSLYLRLQELAALQRQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPLSPFKAPVVVEWAHGVTPKPDSATLGQHVEQLVESVFKNYDPEGHGSISLEDFEKLSANFPFACHGLHPPPRHGSGSFSREELTKYLLHASAICSKLGLAFLHAFQEVTFRKPTFCHSCNGFVSTGPLWGVTKRGYRCQDCGLCCHRHCRDQVRVECKKRPETKGDPGPPGAPGPATPLPPTGCGSEEGLSYTLSPHLESGCHLHHAWTQTESSHSSWEPEMVPCPAPVLPSKASSKSSV", "length": 678 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8TDF6-1", "protein_name": "RAS guanyl-releasing protein 4", "gene_name": "RASGRP4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS", "length": 673 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8TEU7-1", "protein_name": "Rap guanine nucleotide exchange factor 6", "gene_name": "RAPGEF6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIARCWYILLSGSVLVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVVENAKDNEDSILQREIPARQSRRRFRKINYKGERQTITDDVEVNSYLSLPADLTKMHLTENPHPQVTHVSSSQSGCSIASDSGSSSLSDIYQATESEVGDVDLTRLPEGPVDSEDDEEEDEEIDRTDPLQGRDLVRECLEKEPADKTDDDIEQLLEFMHQLPAFANMTMSVRRELCSVMIFEVVEQAGAIILEDGQELDSWYVILNGTVEISHPDGKVENLFMGNSFGITPTLDKQYMHGIVRTKVDDCQFVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVHEHRELDRSGTRKGHIVIKATPERLIMHLIEEHSIVDPTYIEDFLLTYRTFLESPLDVGIKLLEWFKIDSLRDKVTRIVLLWVNNHFNDFEGDPAMTRFLEEFEKNLEDTKMNGHLRLLNIACAAKAKWRQVVLQKASRESPLQFSLNGGSEKGFGIFVEGVEPGSKAADSGLKRGDQIMEVNGQNFENITFMKAVEILRNNTHLALTVKTNIFVFKELLFRTEQEKSGVPHIPKIAEKKSNRHSIQHVPGDIEQTSQEKGSKKVKANTVSGGRNKIRKILDKTRFSILPPKLFSDGGLSQSQDDSIVGTRHCRHSLAIMPIPGTLSSSSPDLLQPTTSMLDFSNPSDIPDQVIRVFKVDQQSCYIIISKDTTAKEVVFHAVHEFGLTGASDTYSLCEVSVTPEGVIKQRRLPDQFSKLADRIQLNGRYYLKNNMETETLCSDEDAQELVKESQLSMLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKLNSKTGNTHLKRFEDIVNQETFWVASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLPSKYEKHLQDLQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFLHEGNDSKVDGLVNFEKLRMISKEIRQVVRMTSANMDPAMMFRQRSLSQGSTNSNMLDVQGGAHKKRARRSSLLNAKKLYEDAQMARKVKQYLSSLDVETDEEKFQMMSLQWEPAYGTLTKNLSEKRSAKSSEMSPVPMRSAGQTTKAHLHQPHRVSQVLQVPAVNLHPIRKKGQTKDPALNTSLPQKVLGTTEEISGKKHTEDTISVASSLHSSPPASPQGSPHKGYTLIPSAKSDNLSDSSHSEISSRSSIVSNCSVDSMSAALQDERCSSQALAVPESTGALEKTEHASGIGDHSQHGPGWTLLKPSLIKCLAVSSSVSNEEISQEHIIIEAADSGRGSWTSCSSSSHDNFQSLPNPKSWDFLNSYRHTHLDDPIAEVEPTDSEPYSCSKSCSRTCGQCKGSLERKSWTSSSSLSDTYEPNYGTVKQRVLESTPAESSEGLDPKDATDPVYKTVTSSTEKGLIVYCVTSPKKDDRYREPPPTPPGYLGISLADLKEGPHTHLKPPDYSVAVQRSKMMHNSLSRLPPASLSSNLVACVPSKIVTQPQRHNLQPFHPKLGDVTDADSEADENEQVSAV", "length": 1601 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q99JE4-1", "protein_name": "Ras-specific guanine nucleotide-releasing factor 2", "gene_name": "Rasgrf2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQKSVRYNEGHALYLAFLARKEGTKRGFLSKKAAEASRWHEKWFALYQNVLFYFEGEQSGRPAGMYLLEGCSCERTPAPPRTNAGPAGARDALDKQYYFTVLFGHEGQKPLELRCEEEQAGKEWMEAIHQASYADILIEREVLMQKYIHLVQIVETEKIAANQLRHQLEDQDTEIERLKSEIVALNKTKERMRPYHTHQEEEDPDIKKIKKVQSFMRGWLCRRKWKTIVQDYICSPHAESMRKRNQIVFTMVEAESEYVHQLYILVNGFLRPLRMAASSKKPPISHDDVSSIFLNSETIMFLHEIFHQGLKARLANWPTLVLADLFDILLPMLNIYQEFVRNHQYSLQVLANCKQNRDFDKLLKQYEGNPACEGRMLETFLTYPMFQIPRYIITLHELLAHTPHEHVERKSLEFAKSKLEELSRVMHDEVSDTENIRKNLAIERMIVEGCDILLDTSQTFIRQGSLIQVPSVERGKLSKVRLGSLSLKKEGERQCFLFTKHFLICTRSSGGKLHLLKTGGVLSLIQCTLIEEPDTSDDDTKGPGHMFGHLDFKIVVEPPDAAPFTVVLLAPSRQEKAAWMSDISQCVDNIRCNGLMTIVFEENSKVTVPHMIKSDARLHKDDTDICFSKTLNSCKVPQIRYASVERLLERLTDLRFLSIDFLNTFLHTYRIFTTAAVVLGKLSDIYKRPFTSIPVRSLELFFATSQNNREHLVDGKSPRLCRKFSSPPPLAVSRTSSPVRARKLSLTSSLNSRIGALDLTTSSSSSSPTTTVHSPAASPPPHTAVPESAPADRAGDSTDMSPCRSPSTTPRHLRYRQPGGQVADSTHCAVSPASAFAIATAAAGHGSPPGFNNERTCDKEFIIRRTATNRVLNVLRHWVSKHSQDFELNNELKMNVLNLLEEVLRDPDLLPQERKATANILRALSQDDQDDIHLKLEDIIQMTDCPKAECFETLSAMELAEQITLLDHIVFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNEMSNLVASQIMNYADISSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWTKVSKQTKALMDKLQKTVSSEGRFKNLRETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQTAYRIDQQPKVIQYLLDKALVIDEDTLYELSLKIEPRLPA", "length": 1190 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9D300-1", "protein_name": "Ras-GEF domain-containing family member 1C", "gene_name": "Rasgef1c", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPRTLTASDMVTPGSLSPPPTESTEGEQAGQPLLDGAPSSASLDTLIQHLVPTADYYPEKAYIFTFLLSSRLFIEPRELLARVCHLCIEQQQLDKPVLDKARVRKFGAKLLQLLAEWTETFPRDFEEESTIGHLTDVVGRISPCDETYGSRVHQLLQTLHQKLASLGQGPESLVGADKPISYRTKPPASIHRELLGVCSDPYTLAQQLTHVELERLRHIGPEEFVQAFVNKDPLAGTKPRFSDKTNNVEAYVKWFNRLCYLVATEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFFILEHQMDPTGNFCNYRTALRGAAHRSLTAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFLELAKQVGEFITWKQVECPFEQDPSITHYLYTAPIFSEDGLYLASYESESPESQTEKERWKSLRSSILGKT", "length": 466 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9QUG9-1", "protein_name": "RAS guanyl-releasing protein 2", "gene_name": "Rasgrp2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTSTLDLDKGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHPWYIPSSQLASKLLHFYQQSRKDNSNSLQMKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDIESVPTYKWKRQVTQRNPVEQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCTVDNPVLERFISLFNSVSQWVQLMILSKPTATQRALVITHFVHVAERLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSPDTIKLWEGLTELVTATGNYSNYRRRLAACVGFRFPILGVHLKDLVALQLALPDWLDPGRTRLNGAKMRQLFCILEELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQREPRSKSSPTSPTSCTPPPRPPVLEEWTSVAKPKLDQALVAEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISREEMISYFLRSSSVLGGRMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQCKERLSVECRRRAQSVSLEGSAPSPSPTHTHHRAFSFSLPRPGRRSSRPPEIREEEVQSVEDGVFDIHL", "length": 608 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9R1K8-1", "protein_name": "RAS guanyl-releasing protein 1", "gene_name": "Rasgrp1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGTLGKAREAPRKPCHGSRAGPKGRLEAKSTNSPLPAQPSLAQITQFRMMVSLGHLAKGASLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIIISSAELLQKLMNLYKDALEKNSPGICLKICYFVRYWITEFWIMFKMDASLTSTMEEFQDLVKANGEESHCHLIDTTQINSRDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIHVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSCRNYDNYRRAYGECTHFKIPILGVHLKDLISLYEAMPDYLEDGKVNVQKLLALYNHINELVQLQDVAPPLDANKDLVHLLTLSLDLYYTEDEIYELSYAREPRNHRAPPLTPSKPPVVVDWASGVSPKPDPKTISKHVQRMVDSVFKNYDLDQDGYISQEEFEKIAASFPFSFCVMDKDREGLISRDEITAYFMRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKRSKSPAVSTENISSVVPMSTLCPLGTKDLLHAPEEGSFIFQNGEVVDHSEESKDRTIMLLGVSSQKISVRLKRTVAHKTTQTESFPWVGGEMPPGHFVLTSPRKSAQGALYVHSPASPCPSPALVRKRAFVKWENKESLIKPKPELHLRLRTYQELEQEVNTLRADNDALKIQLKYAQKQIESLQLGKSNHVLAQMDHGDGT", "length": 795 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9VMF3-1", "protein_name": "Dizzy isoform AII", "gene_name": "PDZ-GEF", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MDPYHHIRHHYPPTSIAGTGVVVGSSTTINRPELHQKCNRGSHSSDTSSAYSGSDTMASNYASSLEAEEIDLSGLVESVVDSDEEDLAESMDSLTVRDAVRDCLEKDPAERSEEDVEVLLEFTQGLKAFTNITLAVRRALCSVMVFAVVDKAGTVVMSDGEELDSWSVLINGAVEIEHANGSREELQMGDSFGILPTMDKLYHRGVMRTKCDDCQFVCITQTDYYRIQHQGEENTRRHEDENGFVVMVTELRSIGGAGTDSAGSGGSATGASASLNMKRGHVVIRGTPERLLQQLVEENSMTDPTYVEDFLLTHRIFIQNPQEVTSKLLHWFDLEQVDAHKTQELRDRVTRVVLLWVNNHFTDFEADYEMMEFLEVFEALLERKKLLSQLRLLHIACAAKARMRSCTLTRSSRDEPLNFRIVGGYELRGVAIATGNAAVGIYISHVEPGSKAQDVGLKRGDQIHEVNGQSLDHVTSKRALEILTGTTHLSISVKSNLLGFKEIMQALEHGGGTAGSGSISAGSGSFKSVRSPRRICANDIAKLHGRSDSTTDELSSVSASNRAHMVRLSSVDMLLDQPDCAPPQTPPVSGSGNMASNFMQQLLQSVNNSSAKKSGGNSNSDQQDTKGGFMTLAPKRRLQKALAKMNLLNKQNHGSSLNDSSDTLLNDPKSKLSAVSSCSSSTQSSINGCTVSGGGRLYQSQSNPDLTSLNYDGGSDAGGNGGGRLQVNYLNAHIHRPSAASTLTTNSTQSHLLPDYPDHVLKVYKADQTCKYVLIYKETTAHEVVMLTLQEFGIHDPSSNFSLCEVSVGDGGMVKQRRLPDQLQNLAERISFAARYYLKLNDSTEPLVPDELALELVRESNVHFLHLNAYELAIQLTLQDFANFRQIESTEYVDELFELRSRYGVPMLSKFAELVNREMFWVVSEICAEHNIVRRMKIVKQFIKIARHCKECRNFNSMFAIVSGLGHGAVSRLRQTWEKLPSKYQRLFNDLQDLMDPSRNMSKYRQLVSAELLAQHPIIPFYPIVKKDLTFIHLGNDTRVDGLINFEKLRMLAKEVRLLTHMCSSPYDLLSILELKGQSPSNALFSLNQMSASQSNAAAGTVIAANAGQATIKRRKKSTAAPNPKKMFEEAQMVRRVKAYLNSLKILSDEDLLHKFSLECEPAHGSTYSGSISHGNTSHRSGGGGSISGGAGGSSGGGGGGSSSLNAGDQLSIYSHTSSSSAPNSSLSLRKRHPSSPTLSTTSSTSSTSDHQRRQMHNNGPKFGTASPQAVKKMLSLSESSKIRPHQPFVPRHGSTMAGVIPPLHHMHAAHGFSTPSPGGVVTSPATSAVANVQCTPSPSPCSHRRLASGGNIIPSRAIHERSHSDTPAPPPPLPSVDLSLESSSVTTFRDLPLRKSVTSGSISSCDSGYVHQQQHYHLQYQQQQQQNSSQHEPSPPVYTAADCRLLQQISNNAVTRNLNSPCQSTNTPPSTPTPPPNQPTATIQLSAPPTAAAYMHARSQHQQLQQQQQSLAMPPPPPPPYNVPPLGSIYSHHQGTAGSRHLNHMHGKTTGPQERWFPDCRPTTKQQMQSGS", "length": 1573 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9Y4G8-1", "protein_name": "Rap guanine nucleotide exchange factor 2", "gene_name": "RAPGEF2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKPLAIPANHGVMGQQEKHSLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLSDIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFNDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAKRRLMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEEKRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGGRNKLKKILDKTRISILPQKPYNDIGIGQSQDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFSATPDLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTATPDQYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCANLKRFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKVDGLVNFEKLRMIAKEIRHVGRMASVNMDPALMFRTRKKKWRSLGSLSQGSTNATVLDVAQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSNLELEMDEESLQTLSLQCEPATNTLPKNPGDKKPVKSETSPVAPRAGSQQKAQSLPQPQQQPPPAHKINQGLQVPAVSLYPSRKKVPVKDLPPFGINSPQALKKILSLSEEGSLERHKKQAEDTISNASSQLSSPPTSPQSSPRKGYTLAPSGTVDNFSDSGHSEISSRSSIVSNSSFDSVPVSLHDERRQRHSVSIVETNLGMGRMERRTMIEPDQYSLGSYAPMSEGRGLYATATVISSPSTEELSQDQGDRASLDAADSGRGSWTSCSSGSHDNIQTIQHQRSWETLPFGHTHFDYSGDPAGLWASSSHMDQIMFSDHSTKYNRQNQSRESLEQAQSRASWASSTGYWGEDSEGDTGTIKRRGGKDVSIEAESSSLTSVTTEETKPVPMPAHIAVASSTTKGLIARKEGRYREPPPTPPGYIGIPITDFPEGHSHPARKPPDYNVALQRSRMVARSSDTAGPSSVQQPHGHPTSSRPVNKPQWHKPNESDPRLAPYQSQGFSTEEDEDEQVSAV", "length": 1499 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9Z1S3-1", "protein_name": "RAS guanyl-releasing protein 1", "gene_name": "Rasgrp1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGTLGKAREAPRKPCHGSRAGPKARLEAKSTNSPLPAQPSLAQITQFRMMVSLGHLAKGASLDDLIDSCIQSFDADGNLCRNNQLLQVMLTMHRIIISSAELLQKVMNLYKDALEKNSPGVCLKICYFVRYWITEFWIMFKMDASLTSTMEEFQDLVKANGEETHCHLIDTTQINSRDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIHVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSCRNYDNYRRAYGECTHFKIPILGVHLKDLISLYEAMPDYLEDGKVNVQKLLALYNHINELVQLQEMAPPLDANKDLVHLLTLSLDLYYTEDEIYELSYAREPRNHRAPPLTPSKPPVVVDWASGVSPKPDPKTISKHVQRMVDSVFKNYDLDQDGYISQEEFEKIAASFPFSFCVMDKDREGLISRDEITAYFMRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKRIKSPAISTENISSVVPMSTLCPLGTKDLLHAPEEGSFIFQNGEIVDHSEESKDRTIMLLGVSSQKISVRLKRTVAHKSTQTESFPWVGGETTPGHFVLSSPRKSAQGALYVHSPASPCPSPALVRKRAFVKWENKESLIKPKPELHLRLRTYQELEQEINTLKADNDALKIQLKYAQKKIESLQLGKSNHVLAQMDHGDSA", "length": 795 }, "evidence": [ { "id": "SGD:S000000022", "url": "https://alliancegenome.org/gene/SGD:S000000022#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAU4", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KAU4" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAU4", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KAU4" } ], "pmid": "" }, { "name": "kinase binding", "id": "GO:0019900", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019900", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAU4", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KAU4" } ], "pmid": "" }, { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAU4", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KAU4" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAU4", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KAU4" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAU4", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KAU4" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAU4", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KAU4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAU4", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KAU4" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAU4", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KAU4" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAU4", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KAU4" } ], "pmid": "" }, { "name": "guanyl-nucleotide exchange factor complex", "id": "GO:0032045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032045", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAU4", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KAU4" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAU4", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KAU4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "Ras protein signal transduction", "id": "GO:0007265", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007265", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KAU4", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KAU4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 30, "end_pos": 32, "annotation": "n_glycosylation_sequon" }, { "start_pos": 345, "end_pos": 347, "annotation": "n_glycosylation_sequon" }, { "start_pos": 61, "end_pos": 63, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A0G2KAU4-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 691, "overlap": "1.0", "method": "AlphaFold", "type": 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