{ "uniprot_canonical_ac": "A0A0G2KA11-1", "uniprot_ac": "A0A0G2KA11", "uniprot_id": "A0A0G2KA11_RAT", "mass": { "chemical_mass": 178728.0, "monoisotopic_mass": 178728.0 }, "refseq": {}, "gene_names": [ { "name": "Prex2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KA11", "id": "A0A0G2KA11" } ], "protein_names": [ { "name": "Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KA11/entry#names_and_taxonomy", "id": "A0A0G2KA11" }, { "name": "DEP domain-containing protein 2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KA11/entry#names_and_taxonomy", "id": "A0A0G2KA11" } ], "function": [ { "annotation": "Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase.", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZPN7", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZPN7#function" }, { "database": "UniProtKB", "id": "ARBA00058808", "url": "https://www.uniprot.org/uniprotkb/ARBA00058808#function" }, { "database": "UniProtKB", "id": "A0A8I6ATE3", "url": "https://www.uniprot.org/uniprotkb/A0A8I6ATE3#function" }, { "database": "UniProtKB", "id": "D3ZW14", "url": "https://www.uniprot.org/uniprotkb/D3ZW14#function" }, { "database": "UniProtKB", "id": "A0A8I6GLM6", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLM6#function" }, { "database": "UniProtKB", "id": "A0A0G2KA11", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KA11#function" } ] } ], "disease": [ { "disease_id": "DOID:2043", "recommended_name": { "id": "DOID:2043", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2043", "name": "hepatitis B", "description": "A viral hepatitis that results_in inflammation located_in liver, has_material_basis_in Hepatitis B virus (Orthohepadnavirus hominoidei), which is transmitted_by sexual contact, blood transfusions, or fomites like needles or syringes. The infection has_symptom fever, fatigue, loss of appetite, nausea, vomiting, abdominal pain, clay-colored bowel movements, joint pain, and jaundice." }, "synonyms": [ { "id": "DOID:2043", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2043", "name": "chronic hepatitis B", "description": "" }, { "id": "DOID:2043", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2043", "name": "hepatitis B infection", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "2043", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:2043" } ] }, { "disease_id": "DOID:3907", "recommended_name": { "id": "DOID:3907", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3907", "name": "lung squamous cell carcinoma", "description": "A non-small cell lung carcinoma that has_material_basis_in the squamous cell." }, "synonyms": [ { "id": "DOID:3907", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3907", "name": "Epidermoid cell carcinoma of the lung", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "3907", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3907" } ] }, { "disease_id": "DOID:3908", "recommended_name": { "id": "DOID:3908", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3908", "name": "lung non-small cell carcinoma", "description": "A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma." }, "synonyms": [ { "id": "DOID:3908", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3908", "name": "NSCLC", "description": "" }, { "id": "DOID:3908", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3908", "name": "Non-small cell lung cancer", "description": "" }, { "id": "DOID:3908", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3908", "name": "non-small cell lung carcinoma", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "3908", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3908" } ] }, { "disease_id": "DOID:4927", "recommended_name": { "id": "DOID:4927", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4927", "name": "Klatskin's tumor", "description": "An intrahepatic cholangiocarcinoma arising near or at the confluence of the right and left hepatic ducts." }, "synonyms": [ { "id": "DOID:4927", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4927", "name": "Klatskin tumor", "description": "" }, { "id": "DOID:4927", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4927", "name": "Klatskin tumour", "description": "" }, { "id": "DOID:4927", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4927", "name": "Klatskin's tumour", "description": "" }, { "id": "DOID:4927", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4927", "name": "Perihilar extrahepatic bile duct carcinoma", "description": "" }, { "id": "DOID:4927", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4927", "name": "hilar cholangiocarcinoma", "description": "" }, { "id": "DOID:4927", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4927", "name": "hilar cholangiocellular carcinoma", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "4927", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4927" } ] }, { "disease_id": "DOID:4947", "recommended_name": { "id": "DOID:4947", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4947", "name": "cholangiocarcinoma", "description": "A bile duct adenocarcinoma that has_material_basis_in bile duct epithelial cells." }, "synonyms": [ { "id": "DOID:4947", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4947", "name": "adult primary Cholangiocarcinoma", "description": "" }, { "id": "DOID:4947", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4947", "name": "adult primary cholangiocellular carcinoma", "description": "" }, { "id": "DOID:4947", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4947", "name": "cholangiosarcoma", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "4947", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4947" } ] }, { "disease_id": "DOID:684", "recommended_name": { "id": "DOID:684", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:684", "name": "hepatocellular carcinoma", "description": "A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver." }, "synonyms": [ { "id": "DOID:684", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:684", "name": "Hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation." }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "HCC", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "cancer, hepatocellular", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma, hepatocellular, malignant", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular adenocarcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, childhood type, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell cancer (hepatocellular carcinoma)", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult primary hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma caused by somatic mutation", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver and intrahepatic bile duct carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cancer", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation." }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "HCC", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "cancer, hepatocellular", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma, hepatocellular, malignant", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular adenocarcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, childhood type, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell cancer (hepatocellular carcinoma)", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult primary hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma caused by somatic mutation", "description": "" }, { "id": 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Classification" ] }, { "id": "IPR036390", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036390", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037367", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037367", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR051832", "url": "https://www.ebi.ac.uk/interpro/entry/IPR051832", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR055251", "url": "https://www.ebi.ac.uk/interpro/entry/IPR055251", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "SNRDSYX", "url": "https://omabrowser.org/oma/group/SNRDSYX/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR22829", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22829", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22829:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22829:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00595", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00595", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00610", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00610", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00621", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00621", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF22697", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22697", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-8948751", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8948751", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-8980692", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8980692", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-9013148", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013148", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-9013149", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013149", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "1307865", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1307865", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A0G2KA11", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KA11", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2KA11-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KA11-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZPN7", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZPN7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZPN7-1", "url": "https://www.uniprot.org/uniprotkb/A0A8I5ZPN7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6ATE3", "url": "https://www.uniprot.org/uniprotkb/A0A8I6ATE3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6ATE3-1", "url": "https://www.uniprot.org/uniprotkb/A0A8I6ATE3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6GLM6", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLM6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6GLM6-1", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLM6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3ZW14", "url": "https://www.uniprot.org/uniprotkb/D3ZW14", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3ZW14-1", "url": "https://www.uniprot.org/uniprotkb/D3ZW14-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSDESARDADKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAAAKLDKNVTEETVKMLFSNIEEILAVHKEFLKVVEECLHPEPNAQQEVGTCFLNFKDKFRIYDEYCSNHEKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLLLKELLKRTPRKHSDYTAVMEALQAMKAVCSNINEAKRQMEKLEVLEEWQAHIEGWEGSNITDTCTEMLMCGVLMKISSGNIQERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYVFRGRINTEVMEVENVDDGTADFHSSGHIVVNGWKIHNTAKNKWFVCMAKSGCIKWELFCLKLGMEQDTWVMISEQGEKLYKMMCKQGNLIKDRKRKLTTFPKCFLGSEFVSWLLEIGEIHRPEEGVHLGQALLENGIIHHVTDKHQFKPEQMLYRFRYDDGTFYPRSEMQDVISKGVRLYCRLHSLFTPVVRDKDYHLRTYKSVVMANKLIDWLIAQGDCRTREEAMIFAVGLCDNGFMHHVLEKSEFKDEPLLFRFFADEEMEGSNMKHRLMKHDLKVVENVIAKSLLIKSNEGSYGFGLEDKNKVPIIKLVEKGSNAEMAGMEVGKKIFAINGDLVFLRPFPEVDCFLKSCLNSRKPLRVLVSTKPRETVKIPDSADGLGFQIRGFGPSVVHAVGRGTVAAAAGLHPGQCIIKVNGINVSKETHASVIAHVTACRKYKRPMKQDSIQWVYDSLESAQEDIQKSHSKPPGDEAGDVFDCKVEDVMDKFNTLAIIDGKKEHVSLTVDNVHLEYGVVYEYDSTAGTKCNVVEKMVEPKGFFSLTAKILEALAKSDEHFVQNCTSLNSLNEVIATDLQSKFTSMCSERVEHVCHRISSYGRFSRVLKNRAWPTFKQAKAKMSPLHSSDFCPTNCHVNVMEVSYPKASASLGSAFGVQLDSRKHNSHDKENRSADPGKLSPMVYIQHTITTMAAPSGLSLGHKDGHGLRYLLKEEDLETQDIYHKLLGKLQTALKEVEMCVCQIDDLLSSITYSPKLERKTTEYVIPTDSDNEKGERNSKRVCFNVAGDEQEDSGHDTVSNRDSYSDCNSNRNSIASFTSICSSQCSSYFHSDEMDSGDELPTSIRISHDKQDKIHTCLEQLFIQLDSITNLLKGRAVVRAFEQTKYLTPGRGLQEFQQEMEAKLSCPRRLRLHLKQDPWNLPSGVRALAQSFRKYVEEVKCRILLALLEYSDSETQLRRDMVFCQSLVATVCAFSEQLMAALNQMFDNSKENEMETWEASRRWLDQIANAGVLFHFQSLLSPNLKDEQAMLEDTLVALFDLEKVSFFFKPSEEEPLVANVPLTYQVEGSRQALKVVFYMDSYHFEQLPQRLKNGGGFKIHPVLFSQALESMEGYCYRDNISVEEFQAQINTASLEKVKQYNQKLRAFYLDKSNSPPNATSKAAYIEKLMRPLNALDELYRLVTSFIRSKRIAACVNTPCSASGVGLLSVSSELCDRLGACHIIMCSSGVHRCTLSVTLEQAITLARSHGLPPRYIMQATDVMRKQGARVQNTAKNLGVRDRTPQSAPR", "length": 1573, "header": "tr|A0A0G2KA11-1|A0A0G2KA11_RAT Isoform 1 of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein OS=Rattus norvegicus OX=10116 GN=Prex2 PE=1 SV=2 CANONICAL=A0A0G2KA11-1" }, "isoforms": [ { "isoform_ac": "A0A0G2KA11-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KA11/entry#A0A0G2KA11-1", "sequence": { "sequence": "MSDESARDADKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAAAKLDKNVTEETVKMLFSNIEEILAVHKEFLKVVEECLHPEPNAQQEVGTCFLNFKDKFRIYDEYCSNHEKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLLLKELLKRTPRKHSDYTAVMEALQAMKAVCSNINEAKRQMEKLEVLEEWQAHIEGWEGSNITDTCTEMLMCGVLMKISSGNIQERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYVFRGRINTEVMEVENVDDGTADFHSSGHIVVNGWKIHNTAKNKWFVCMAKSGCIKWELFCLKLGMEQDTWVMISEQGEKLYKMMCKQGNLIKDRKRKLTTFPKCFLGSEFVSWLLEIGEIHRPEEGVHLGQALLENGIIHHVTDKHQFKPEQMLYRFRYDDGTFYPRSEMQDVISKGVRLYCRLHSLFTPVVRDKDYHLRTYKSVVMANKLIDWLIAQGDCRTREEAMIFAVGLCDNGFMHHVLEKSEFKDEPLLFRFFADEEMEGSNMKHRLMKHDLKVVENVIAKSLLIKSNEGSYGFGLEDKNKVPIIKLVEKGSNAEMAGMEVGKKIFAINGDLVFLRPFPEVDCFLKSCLNSRKPLRVLVSTKPRETVKIPDSADGLGFQIRGFGPSVVHAVGRGTVAAAAGLHPGQCIIKVNGINVSKETHASVIAHVTACRKYKRPMKQDSIQWVYDSLESAQEDIQKSHSKPPGDEAGDVFDCKVEDVMDKFNTLAIIDGKKEHVSLTVDNVHLEYGVVYEYDSTAGTKCNVVEKMVEPKGFFSLTAKILEALAKSDEHFVQNCTSLNSLNEVIATDLQSKFTSMCSERVEHVCHRISSYGRFSRVLKNRAWPTFKQAKAKMSPLHSSDFCPTNCHVNVMEVSYPKASASLGSAFGVQLDSRKHNSHDKENRSADPGKLSPMVYIQHTITTMAAPSGLSLGHKDGHGLRYLLKEEDLETQDIYHKLLGKLQTALKEVEMCVCQIDDLLSSITYSPKLERKTTEYVIPTDSDNEKGERNSKRVCFNVAGDEQEDSGHDTVSNRDSYSDCNSNRNSIASFTSICSSQCSSYFHSDEMDSGDELPTSIRISHDKQDKIHTCLEQLFIQLDSITNLLKGRAVVRAFEQTKYLTPGRGLQEFQQEMEAKLSCPRRLRLHLKQDPWNLPSGVRALAQSFRKYVEEVKCRILLALLEYSDSETQLRRDMVFCQSLVATVCAFSEQLMAALNQMFDNSKENEMETWEASRRWLDQIANAGVLFHFQSLLSPNLKDEQAMLEDTLVALFDLEKVSFFFKPSEEEPLVANVPLTYQVEGSRQALKVVFYMDSYHFEQLPQRLKNGGGFKIHPVLFSQALESMEGYCYRDNISVEEFQAQINTASLEKVKQYNQKLRAFYLDKSNSPPNATSKAAYIEKLMRPLNALDELYRLVTSFIRSKRIAACVNTPCSASGVGLLSVSSELCDRLGACHIIMCSSGVHRCTLSVTLEQAITLARSHGLPPRYIMQATDVMRKQGARVQNTAKNLGVRDRTPQSAPR", "length": 1573, "header": "tr|A0A0G2KA11-1|A0A0G2KA11_RAT Isoform 1 of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein OS=Rattus norvegicus OX=10116 GN=Prex2 PE=1 SV=2 CANONICAL=A0A0G2KA11-1" }, "locus": { "chromosome": "5", "start_pos": 8252656, "end_pos": 7950814, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000079917.2", "url": "https://www.ensembl.org/id/ENSRNOT00000079917.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000075213.2", "url": "https://www.ensembl.org/id/ENSRNOP00000075213.2" } ] } }, { "isoform_ac": "A0A8I5ZPN7-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KA11/entry#A0A8I5ZPN7-1", "sequence": { "sequence": "MSDESARDADKQLRLRVCVLSELQKTERDYVGTLEFLVSNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLLLKELLKRTPRKHSDYTAVMEALQAMKAVCSNINEAKRQMEKLEVLEEWQAHIEGWEGSNITDTCTEMLMCGVLMKISSGNIQERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYVFRGRINTEVMEVENVDDGTADFHSSGHIVVNGWKIHNTAKNKWFVCMAKSPEEKHEWFEAILKERERRKGLKLGMEQDTWVMISEQGEKLYKMMCKQGNLIKDRKRKLTTFPKCFLGSEFVSWLLEIGEIHRPEEGVHLGQALLENGIIHHVTDKHQFKPEQMLYRFRYDDGTFYPRSEMQDVISKGVRLYCRLHSLFTPVVRDKDYHLRTYKSVVMANKLIDWLIAQGDCRTREEAMIFAVGLCDNGFMHHVLEKSEFKDEPLLFRFFADEEMEGSNMKHRLMKHDLKVVENVIAKSLLIKSNEGSYGFGLEDKNKVPIIKLVEKGSNAEMAGMEVGKKIFAINGDLVFLRPFPEVDCFLKSCLNSRKPLRVLVSTKPRETVKIPDSADGLGFQIRGFGPSVVHAVGRGTVAAAAGLHPGQCIIKVNGINVSKETHASVIAHVTACRKYKRPMKQDSIQWVYDSLESAQEDIQKSHSKPPGDEAGDVFDCKVEDVMDKFNTLAIIDGKKEHVSLTVDNVHLEYGVVYEYDSTAGTKCNVVEKMVEPKGFFSLTAKILEALAKSDEHFVQNCTSLNSLNEVIATDLQSKFTSMCSERVEHVCHRISSYGRFSRVLKNRAWPTFKQAKAKMSPLHSSDFCPTNCHVNVMEVSYPKASASLGSAFGVQLDSRKHNSHDKENRSADPGKLSPMVYIQHTITTMAAPSGLSLGHKDGHGLRYLLKEEDLETQDIYHKLLGKLQTALKEVEMCVCQIDDLLSSITYSPKLERKTTEYVIPTDSDNEKGERNSKRVCFNVAGDEQEDSGHDTVSNRDSYSDCNSNRNSIASFTSICSSQCSSYFHSDEMDSGDELPTSIRISHDKQDKIHTCLEQLFIQLDSITNLLKGRAVVRAFEQTKYLTPGRGLQEFQQEMEAKLSCPRRLRLHLKQDPWNLPSGVRALAQSFRKYVEEVKCRILLALLEYSDSETQLRRDMVFCQSLVATVCAFSEQLMAALNQMFDNSKENEMETWEASRRWLDQIANAGVLFHFQSLLSPNLKDEQAMLEDTLVALFDLEKVSFFFKPSEEEPLVANVPLTYQVEGSRQALKVVFYMDSYHFEQLPQRLKNGGGFKIHPVLFSQALESMEGYCYRDNISVEEFQAQINTASLEKVKQYNQKLRAFYLDKSNSPPNATSKAAYIEKLMRPLNALDELYRLVTSFIRSKRIAACVNTPCSASGVGLLSVSSELCDRLGACHIIMCSSGVHRCTLSVTLEQAITLARSHGLPPRYIMQATDVMRKQGARVQNTAKNLGVRDRTPQSAPRLYKLCEPPPPVGDE", "length": 1498, "header": "tr|A0A8I5ZPN7-1|A0A0G2KA11_RAT Computationally mapped isoform of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein OS=Rattus norvegicus OX=10116 GN=Prex2 PE=1 SV=1 CANONICAL=A0A0G2KA11-1" }, "locus": { "chromosome": "5", "start_pos": 8252656, "end_pos": 7943463, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000116125.1", "url": "https://www.ensembl.org/id/ENSRNOT00000116125.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000080155.1", "url": "https://www.ensembl.org/id/ENSRNOP00000080155.1" } ] } }, { "isoform_ac": "A0A8I6ATE3-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KA11/entry#A0A8I6ATE3-1", "sequence": { "sequence": "MSDESARDADKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAAAKLDKNVTEETVKMLFSNIEEILAVHKEFLKVVEECLHPEPNAQQEVGTCFLNFKDKFRIYDEYCSNHEKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLLLKELLKRTPRKHSDYTAVMEALQAMKAVCSNINEAKRQMEKLEVLEEWQAHIEGWEGSNITDTCTEMLMCGVLMKISSGNIQERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYVFRGRINTEVMEVENVDDGTADFHSSGHIVVNGWKIHNTAKNKWFVCMAKSPEEKHEWFEAILKERERRKGLKLGMEQDTWVMISEQGEKLYKMMCKQGNLIKDRKRKLTTFPKCFLGSEFVSWLLEIGEIHRPEEGVHLGQALLENGIIHHVTDKHQFKPEQMLYRFRYDDGTFYPRSEMQDVISKGVRLYCRLHSLFTPVVRDKDYHLRTYKSVVMANKLIDWLIAQGDCRTREEAMIFAVGLCDNGFMHHVLEKSEFKDEPLLFRFFADEEMEGSNMKHRLMKHDLKVVENVIAKSLLIKSNEGSYGFGLEDKNKVPIIKLVEKGSNAEMAGMEVGKKIFAINGDLVFLRPFPEVDCFLKSCLNSRKPLRVLVSTKPRETVKIPDSADGLGFQIRGFGPSVVHAVGRGTVAAAAGLHPGQCIIKVNGINVSKETHASVIAHVTACRKYKRPMKQDSIQWVYDSLESAQEDIQKSHSKPPGDEAGDVFDCKVEDVMDKFNTLAIIDGKKEHVSLTVDNVHLEYGVVYEYDSTAGTKCNVVEKMVEPKGFFSLTAKILEALAKSDEHFVQNCTSLNSLNEVIATDLQSKFTSMCSERVEHVCHRISSYGRFSRVLKNRAWPTFKQAKAKMSPLHSSDFCPTNCHVNVMEVSYPKASASLGSAFGVQLDSRKHNSHDKENRSADPGKLSPMVYIQHTITTMAAPSGLSLGHKDGHGLRYLLKEEDLETQDIYHKLLGKLQTALKEVEMCVCQIDDLLSSITYSPKLERKTTEYVIPTDSDNEKGERNSKRVCFNVAGDEQEDSGHDTVSNRDSYSDCNSNRNSIASFTSICSSQCSSYFHSDEMDSGDELPTSIRISHDKQDKIHTCLEQLFIQLDSITNLLKGRAVVRAFEQTKYLTPGRGLQEFQQEMEAKLSCPRRLRLHLKQDPWNLPSGVRALAQSFRKYVEEVKCRILLALLEYSDSETQLRRDMVFCQSLVATVCAFSEQLMAALNQMFDNSKENEMETWEASRRWLDQIANAGVLFHFQSLLSPNLKDEQAMLEDTLVALFDLEKVSFFFKPSEEEPLVANVPLTYQVEGSRQALKVVFYMDSYHFEQLPQRLKNGGGFKIHPVLFSQALESMEGYCYRDNISVEEFQAQINTASLEKVKQYNQKLRAFYLDKSNSPPNATSKAAYIEKLMRPLNALDELYRLVTSFIRSKRIAACVNTPCSASGV", "length": 1500, "header": "tr|A0A8I6ATE3-1|A0A0G2KA11_RAT Computationally mapped isoform of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein OS=Rattus norvegicus OX=10116 GN=Prex2 PE=1 SV=1 CANONICAL=A0A0G2KA11-1" }, "locus": { "chromosome": "5", "start_pos": 8252656, "end_pos": 7975363, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000108865.1", "url": "https://www.ensembl.org/id/ENSRNOT00000108865.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000095390.1", "url": "https://www.ensembl.org/id/ENSRNOP00000095390.1" } ] } }, { "isoform_ac": "A0A8I6GLM6-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KA11/entry#A0A8I6GLM6-1", "sequence": { "sequence": "MCGVLMKISSGNIQERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYVFRGRINTEVMEVENVDDGTADFHSSGHIVVNGWKIHNTAKNKWFVCMAKSGCIKWELFCLKLGMEQDTWVMISEQGEKLYKMMCKQGNLIKDRKRKLTTFPKCFLGSEFVSWLLEIGEIHRPEEGVHLGQALLENGIIHHVTDKHQFKPEQMLYRFRYDDGTFYPRSEMQDVISKGVRLYCRLHSLFTPVVRDKDYHLRTYKSVVMANKLIDWLIAQGDCRTREEAMIFAVGLCDNGFMHHVLEKSEFKDEPLLFRFFADEEMEGSNMKHRLMKHDLKVVENVIAKSLLIKSNEGSYGFGLEDKNKVPIIKLVEKGSNAEMAGMEVGKKIFAINGDLVFLRPFPEVDCFLKSCLNSRKPLRVLVSTKPRETVKIPDSADGLGFQIRGFGPSVVHAVGRGTVAAAAGLHPGQCIIKVNGINVSKETHASVIAHVTACRKYKRPMKQDSIQWVYDSLESAQEDIQKSHSKPPGDEAGDVFDCKVEDVMDKFNTLAIIDGKKEHVSLTVDNVHLEYGVVYEYDSTAGTKCNVVEKMVEPKGFFSLTAKILEALAKSDEHFVQNCTSLNSLNEVIATDLQSKFTSMCSERVEHVCHRISSYGRFSRVLKNRAWPTFKQAKAKMSPLHSSDFCPTNCHVNVMEVSYPKASASLGSAFGVQLDSRKHNSHDKENRSADPGKLSPMVYIQHTITTMAAPSGLSLGHKDGHGLRYLLKEEDLETQDIYHKLLGKLQTALKEVEMCVCQIDDLLSSITYSPKLERKTTEYVIPTDSDNEKGERNSKRVCFNVAGDEQEDSGHDTVSNRDSYSDCNSNRNSIASFTSICSSQCSSYFHSDEMDSGDELPTSIRISHDKQDKIHTCLEQLFIQVSWDSGVSFVFFSITDSETQLRRDMVFCQSLVATVCAFSEQLMAALNQMFDNSKENEMETWEASRRWLDQIANAGVLFHFQSLLSPNLKDEQAMLEDTLVALFDLEKVSFFFKPSEEEPLVANVPLTYQVEGSRQALKVVFYMDSYHFEQLPQRLKNGGGFKIHPVLFSQALESMEGYCYRDNISVEEFQAQINTASLEKVKQYNQKLRCTLSVTLEQAITLARSHGLPPRYIMQATDVMRKQGARVQNTAKNLGVRDRTPQSAPR", "length": 1176, "header": "tr|A0A8I6GLM6-1|A0A0G2KA11_RAT Computationally mapped isoform of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein OS=Rattus norvegicus OX=10116 GN=Prex2 PE=1 SV=1 CANONICAL=A0A0G2KA11-1" }, "locus": { "chromosome": "5", "start_pos": 8157626, "end_pos": 7950814, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000108148.1", "url": "https://www.ensembl.org/id/ENSRNOT00000108148.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000096523.1", "url": "https://www.ensembl.org/id/ENSRNOP00000096523.1" } ] } }, { "isoform_ac": "D3ZW14-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KA11/entry#D3ZW14-1", "sequence": { "sequence": "MCGVLMKISSGNIQERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYVFRGRINTEVMEVENVDDGTADFHSSGHIVVNGWKIHNTAKNKWFVCMAKSPEEKHEWFEAILKERERRKGLKLGMEQDTWVMISEQGEKLYKMMCKQGNLIKDRKRKLTTFPKCFLGSEFVSWLLEIGEIHRPEEGVHLGQALLENGIIHHVTDKHQFKPEQMLYRFRYDDGTFYPRSEMQDVISKGVRLYCRLHSLFTPVVRDKDYHLRTYKSVVMANKLIDWLIAQGDCRTREEAMIFAVGLCDNGFMHHVLEKSEFKDEPLLFRFFADEEMEGSNMKHRLMKHDLKVVENVIAKSLLIKSNEGSYGFGLEDKNKVPIIKLVEKGSNAEMAGMEVGKKIFAINGDLVFLRPFPEVDCFLKSCLNSRKPLRVLVSTKPRETVKIPDSADGLGFQIRGFGPSVVHAVGRGTVAAAAGLHPGQCIIKVNGINVSKETHASVIAHVTACRKYKRPMKQDSIQWVYDSLESAQEDIQKSHSKPPGDEAGDVFDCKVEDVMDKFNTLAIIDGKKEHVSLTVDNVHLEYGVVYEYDSTAGTKCNVVEKMVEPKGFFSLTAKILEALAKSDEHFVQNCTSLNSLNEVIATDLQSKFTSMCSERVEHVCHRISSYGRFSRVLKNRAWPTFKQAKAKMSPLHSSDFCPTNCHVNVMEVSYPKASASLGSAFGVQLDSRKHNSHDKENRSADPGKLSPMVYIQHTITTMAAPSGLSLGHKDGHGLRYLLKEEDLETQDIYHKLLGKLQTALKEVEMCVCQIDDLLSSITYSPKLERKTTEYVIPTDSDNEKGERNSKRVCFNVAGDEQEDSGHDTVSNRDSYSDCNSNRNSIASFTSICSSQCSSYFHSDEMDSGDELPTSIRISHDKQDKIHTCLEQLFIQLDSITNLLKGRAVVRAFEQTKYLTPGRGLQDSETQLRRDMVFCQSLVATVCAFSEQLMAALNQMFDNSKENEMETWEASRRWLDQIANAGVLFHFQSLLSPNLKDEQAMLEDTLVALFDLEKVSFFFKPSEEEPLVANVPLTYQVEGSRQALKVVFYMDSYHFEQLPQRLKNGGGFKIHPVLFSQALESMEGYCYRDNISVEEFQAQINTASLEKVKQYNQKLRCTLSVTLEQAITLARSHGLPPRYIMQATDVMRKQGARVQNTAKNLGVRDRTPQSAPRLYKLCEPPPPVGDE", "length": 1216, "header": "tr|D3ZW14-1|A0A0G2KA11_RAT Computationally mapped isoform of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein OS=Rattus norvegicus OX=10116 GN=Prex2 PE=1 SV=1 CANONICAL=A0A0G2KA11-1" }, "locus": { "chromosome": "5", "start_pos": 8157626, "end_pos": 7943463, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000064774.4", "url": "https://www.ensembl.org/id/ENSRNOT00000064774.4" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000063421.1", "url": "https://www.ensembl.org/id/ENSRNOP00000063421.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nat. Commun.", "date": "2012", "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV", "evidence": [ { "database": "UniProtKB", "id": "D3ZW14", "url": "https://www.uniprot.org/uniprotkb/D3ZW14" } ], "reference": [ { "type": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" } ] } ], "pathway": [ { "id": "R-RNO-8948751", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8948751", "resource": "Reactome", "description": "Regulation of PTEN stability and activity" }, { "id": "R-RNO-8980692", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8980692", "resource": "Reactome", "description": "RHOA GTPase cycle" }, { "id": "R-RNO-9013148", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013148", "resource": "Reactome", "description": "CDC42 GTPase cycle" }, { "id": "R-RNO-9013149", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9013149", "resource": "Reactome", "description": "RAC1 GTPase cycle" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287BLK5-1", "protein_name": "Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein", "gene_name": "PREX2", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MSDESRGDSRAESARDLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLFELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLLLKELLKRTPRKHSDYAAVVEALQAMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKISSGNIQERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDDGTADFHSSGHIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWLEAILKERERRKGLKLGMEQDTWVMISEQGEKLYKMMCKQGNLIKDRKRKLTTFPKCFLGSEFVSWLLEIGEIHRPEEGVHLGQALLENGIIHHVTDKHQFKPEQMLYRFRYDDGTFYPRNEMQDVISKGVRLYCRLHSLFTPVIRDKDYHLRTYKSVVMANKLIDWLIAQGDCRTREEAMIFGVGLCDNGFMHHVLEKSEFKDEPLLFRFFADEEMEGSNMKHRLMKHDLKVVENVIAKSLLIKSNEGSYGFGLEDKNKVPIIKLVEKGSNAEMAGMEVGKKIFAINGDLVFMRPFNEVDCFLKSCLNSRKPLRVLVSTKPRETVKIPDSAEGLGFQIRGYGPSVVHAVGRGTVAAAAGLHPGQCIIKVNGINVSKETHASVIAHVTACRKYRRPTKQDSIQWVYNSVESAQEDLQKSHSRPAGDEAGDAFDCKVEEVIDKFNTMAIIDGKKEHVSLTVDNVHLEYGVVYEYDSTAGIKCNVVEKMIEPKGFFSLTAKILEALAKSDDHFVQNCTSLNSLNEVIPTDLQSKFSAVCSEKIEHICQRISSYKKFSRVLKNRAWPTFKQAKSKISPLHSSDFCPTNCHVNVMEVSYPKTSTSLGSAFGVQLDNRKPNSHDKENKSEQGKLSPMVYIQHTITTMAAPSGLSLGQQDGHGLRYLLKEEDLETQDIYHKLLGKLQTALKEVELCVCQIDDLLSSITHSPKLERKASESIAPADSDNEKGERNSKRVCFNMVGDEQEDSGHDTISNRDSYSDCNSNRNSIASFTSICSSQCSSYFHSDEMDSGDELPLNVRISHDKQDKIHSCLEHLFSQVDSITNLLKGQAVVRAFEQTKYLTPGRGLQEFQQEMEPKLSCPKRLRLHIKQDPWNLPSSVRNLAQNIRKFVEEVKCRILLALLEYSDSETQLRRDMVFCQSLVATVCAFSEQLMAALNQMFDNSKENEMETWEASRRWLDQIANAGVLFHFQSLLSPNLTDEQAMLEDTLVALFDLEKVSFYFKPSEEEPLVANVPLTYQAEGSRQALKVYFYIDSYHFEQLPQRLKNGGGFKIHPVLFAQALESMEGYYYRDNVSVEEFQAQINAASLEKVKQYNQKLRAFYLDKSNSPPNSTSKAAYVDKLMRPLNALDELYRLVASFIRSKRTAACANTACSASGVGLLSVSSELCSRLGACHVIMCNSGVHRCTLSVTLEQAIILARSHGLPPRYIMQATDVMRKQGARVQNTAKNLGVRDRTPQSAPRLYKLCEPPPPVGEE", "length": 1605 }, "evidence": [ { "id": "A0A0G2KA11", "url": "https://omabrowser.org/oma/group/A0A0G2KA11/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "E7F2H9-1", "protein_name": "Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein", "gene_name": "prex2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTEESKAEHRAESGKDLEKQLRLRVCVLNELLKTERDYVGTLEFLSVLLHRLNQYAASKIDKNITEETVKVLFSNLEEILSVHRDFLNMVEELLQPDPNPYHEVGHCFLHFRGRFQIYDEYCGNHEKAQRLLLELNKIRTVRTLLLNCMLLGGRKNTEVPLEGYLVAPIQRICKYPLILRELLKRTPKKHNDYSKVQESLQVMKAVCSSINEAKRQMEKLEVLEEWQSHIEGWEGSNITDSCTEMLMQGILLKISAGNIQERIFFLFDNLLVYCKKKNRRLKNSKAATEGPRYLFRGRINTEVMEVENVDDGTADFHSSGNIVNNGWKIHNTAKNKWFVCMAKTPEEKQEWLEAILKERERRKTLRLGMEQDTWVMISEKGEKFYNLMSKQGHLIKDRKRKLTTFPKCFLGSEFVSWLMDIGETNNPEEGVHLGQALLENGIIHHVTDKHQFKPEPVLYRFRYDDGTYHPRSDMQDVISKGVRLFCRLHSLFTPVIRDKDYHLRTYKSVVMANKLIDWLIAQGDCRSREEALILGVELCDNGFMHHVLEKSEFKDEPLLFRFFADEEMEGSNTKHKPIKHDLKIVENVIAKSLLIKPSEGGYGFTLEDRNRVPIVKSVEKGSHAEMAGLEVGKKIFAINGDLVFLRPFQEVENFLKQCFHSRGPIRVLVSTKPRETVKIPDSADGLGFQIRGFGPSVVHAVGRGTVAAVAGLHPGQCIIKVNGINVSKESHASVIAHVTACRKYRRPTQQDSIKWVYNNSESAQEDHQRSNQKPTTGDNGDVFECKVEEVMDKFNTIAIIDGKKDHVSLTVDNVYLEYGVMYEYDSTAGMKCHVLEKMVEPKGFFSLTAKILEALARNDEQLVQTCSRLSSSAELIPEDLQTRFTAMCGERLEHINRRITNYRKFSRVLKNRAWPTFKQAKSKVSPLHSSDFCPTNCHINVMEVSYPKTTTSLGSAFGVQLDNRKNTLEKGSRNSEQGKLNPMVYVQHSITSMAAPSGHSLSRAEGHGLRFLLREDDLLILDAYHKLLTKLTTVVKEMECYAAQIHDLLSSITHPTGSEGKPTESYISAESESDRSERNGKKVCFNVAGDEQEDSGHDTISNRDSYSDCNSNRNSIASFTSICSSHCSSYVHSDEMDSGDEMPTSVWISHDKQKKLHGFLEHLFSQVESITSLLKGATVTRAFEQTKCFTPGRGLQEFHQDMEPKLNCTKKLRLHVKQDPWNLPSSVQTLTHTISRFAEEVKTRLLLVLLQYTDSEIQLRRDMVFSQSLVAVVCSFSEQLLAVLNQALSTESESHEASRRWLEQISSAGLLFHFQSLLSPNLTDEQAMLEDTQVALMDLEKVTFCFRQFEGEPLVANMPISYQVEGTRQALKVCFFLEAFYFQQLPQRLRHGGSFKIYPVLFTQALESMEGYYYRENVSVEEYQAQINAGSLEKVKQYYKRLRAFYLDKSNLTNSSAPKAAFIDKLMRPLNAMDELYRLMESFISCRRTAACQFTACGASGVGLLTVASELCSRLGACHIVMCNSGVHRCTLSVTLEQAILLARNHGLPPRCIMQATDVMRKQGARVQNSAKNLGVRDRTPSTVPRLYKLCQPPPPDGDP", "length": 1600 }, "evidence": [ { "id": "HGNC:22950", "url": "https://alliancegenome.org/gene/HGNC:22950#orthology", "database": "AGR" }, { "id": "MGI:1923385", "url": "https://alliancegenome.org/gene/MGI:1923385#orthology", "database": "AGR" }, { "id": "A0A0G2KA11", "url": "https://omabrowser.org/oma/group/A0A0G2KA11/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q3LAC4-1", "protein_name": "Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein", "gene_name": "Prex2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSDESAREVDKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAAAKVDKNVTEETVKMLFSNIEEILIVHKEFLKVVEECLYPEPSAQQEVGACFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLLLKELLKRTPRRHSDYTAVMEALQAMKAVCSNINEAKRQMEKLEVLEEWQAHIEGWEGSNITDTCTEMLMCGVLMKISSGNIQERVFFLFDNLLVYCKRKHRRLKNSKASTDGYRYVFRGRINTEVMEVENVDDGTADFHSSGHIVVNGWKIHNTAKNKWFVCMAKSPEEKHEWFEAILKERERRKGLKLGMEQDTWVMISEQGEKLYKMMCKQGNLIKDRKRKLTTFPKCFLGSEFVSWLLEIGEIHRPEEGVHLGQALLENGIIHHVTDKHQFKPEQMLYRFRYDDGTFYPRSEMQDVISKGVRLYCRLHSLFTPVVRDKDYHLRTYKSVVMANKLIDWLIAQGDCRTREEAMIFAVGLCDNGFMHHVLEKSEFKDEPLLFRFFADEEMEGSNMKHRLMKHDLKVVENVIAKSLLIKSNEGSYGFGLEDKNKVPIIKLVEKGSNAEMAGMEVGKKIFAINGDLVFLRPFPEVDCFLKSCLNSRKPLRVLVSTKPRETVKIPDSADGLGFQIRGFGPSVVHAVGRGTVAAAAGLHPGQCIIKVNGINVSKETHASVIAHVTACRKYKRPMKQDSIQWVYDSLESAQEDIQKSHSKPPGDGAGDAFECKVEDVIDKFNTMAIIDGKKEHVSLTVDNVHLEYGVVYEYDSTAGTKCNVVEKMVEPKGFFSLTAKILEALAKSDEHFVQNCTSLNSLNEVIATDLQSKFTSMCSERIEHVCHRISSYGRFSRVLKNRAWPTFKQAKPKISPLHSSDFCPTNCHVNVMEVSYPKTSTSLGSAFGVQLDSRKHNSHDKENKSVEPGKLSPMVYIQHTITTMAAPSGLSLGHKDGHGLQYLLKEEDLETQDIYHKLLGKLQTALKEVEMSVCQIDDLLSSITYSPKLERKTTECVTPMDSDNEKGERNSKRVCFNVAGDEQEDSGHDTVSNRDSYSDCNSNRNSIASFTSICSSQCSSYFHSDEMDSGDELPISVRISHDKQDKIHTCLEQLFSQIDSIINLLKGQAVIRAFEQTKYLTPGRGLQEFQQEMEAKLSCPRRLRLHLKQDPWNLPSSIQALAQSIRKHAEEVKCRILLALLEYSDSETQLRRDMVFCQSLVATVCAFSEQLMAALNQMFDNSKENEMETCEASRRWLDQIANAGVLFHFQSLLSPNLKDEQAMLEDTLVALFDLEKVSFFFKPSEEDPLVANVPLTYQVEGSRQALKVYFYMDSYHFEQLPQRLKNGGGFKIHPVLFSQALESMEGYCYRDNISVEEFQAQINTASLEKVKQYNQKLRAFYLDKSNSPPNTTSKAAYIDKLMKPLNALDELYRLITSFIRSKRIAACVNTPCSASGVGLLSVSSELCDRLGACHIIMCSSGVHRCTLSVTLEQTITLARSHGLPPRYIMQAMDVMRKQGARVQNTAKNLGVRDRTPQSAPRLYKLCEPPPPVGEE", "length": 1598 }, "evidence": [ { "id": "HGNC:22950", "url": "https://alliancegenome.org/gene/HGNC:22950#orthology", "database": "AGR" }, { "id": "MGI:1923385", "url": "https://alliancegenome.org/gene/MGI:1923385#orthology", "database": "AGR" }, { "id": "RGD:1307865", "url": "https://alliancegenome.org/gene/RGD:1307865#orthology", "database": "AGR" }, { "id": "A0A0G2KA11", "url": "https://omabrowser.org/oma/group/A0A0G2KA11/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q70Z35-1", "protein_name": "Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein", "gene_name": "PREX2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSEDSRGDSRAESAKDLEKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRTIRTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQAMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKISSGNIQERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDDGTADFHSSGHIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAILKERERRKGLKLGMEQDTWVMISEQGEKLYKMMCRQGNLIKDRKRKLTTFPKCFLGSEFVSWLLEIGEIHRPEEGVHLGQALLENGIIHHVTDKHQFKPEQMLYRFRYDDGTFYPRNEMQDVISKGVRLYCRLHSLFTPVIRDKDYHLRTYKSVVMANKLIDWLIAQGDCRTREEAMIFGVGLCDNGFMHHVLEKSEFKDEPLLFRFFSDEEMEGSNMKHRLMKHDLKVVENVIAKSLLIKSNEGSYGFGLEDKNKVPIIKLVEKGSNAEMAGMEVGKKIFAINGDLVFMRPFNEVDCFLKSCLNSRKPLRVLVSTKPRETVKIPDSADGLGFQIRGFGPSVVHAVGRGTVAAAAGLHPGQCIIKVNGINVSKETHASVIAHVTACRKYRRPTKQDSIQWVYNSIESAQEDLQKSHSKPPGDEAGDAFDCKVEEVIDKFNTMAIIDGKKEHVSLTVDNVHLEYGVVYEYDSTAGIKCNVVEKMIEPKGFFSLTAKILEALAKSDEHFVQNCTSLNSLNEVIPTDLQSKFSALCSERIEHLCQRISSYKKFSRVLKNRAWPTFKQAKSKISPLHSSDFCPTNCHVNVMEVSYPKTSTSLGSAFGVQLDSRKHNSHDKENKSSEQGKLSPMVYIQHTITTMAAPSGLSLGQQDGHGLRYLLKEEDLETQDIYQKLLGKLQTALKEVEMCVCQIDDLLSSITYSPKLERKTSEGIIPTDSDNEKGERNSKRVCFNVAGDEQEDSGHDTISNRDSYSDCNSNRNSIASFTSICSSQCSSYFHSDEMDSGDELPLSVRISHDKQDKIHSCLEHLFSQVDSITNLLKGQAVVRAFDQTKYLTPGRGLQEFQQEMEPKLSCPKRLRLHIKQDPWNLPSSVRTLAQNIRKFVEEVKCRLLLALLEYSDSETQLRRDMVFCQTLVATVCAFSEQLMAALNQMFDNSKENEMETWEASRRWLDQIANAGVLFHFQSLLSPNLTDEQAMLEDTLVALFDLEKVSFYFKPSEEEPLVANVPLTYQAEGSRQALKVYFYIDSYHFEQLPQRLKNGGGFKIHPVLFAQALESMEGYYYRDNVSVEEFQAQINAASLEKVKQYNQKLRAFYLDKSNSPPNSTSKAAYVDKLMRPLNALDELYRLVASFIRSKRTAACANTACSASGVGLLSVSSELCNRLGACHIIMCSSGVHRCTLSVTLEQAIILARSHGLPPRYIMQATDVMRKQGARVQNTAKNLGVRDRTPQSAPRLYKLCEPPPPAGEE", "length": 1606 }, "evidence": [ { "id": "HGNC:22950", "url": "https://alliancegenome.org/gene/HGNC:22950#orthology", "database": "AGR" }, { "id": "MGI:1923385", "url": "https://alliancegenome.org/gene/MGI:1923385#orthology", "database": "AGR" }, { "id": "RGD:1307865", "url": "https://alliancegenome.org/gene/RGD:1307865#orthology", "database": "AGR" }, { "id": "A0A0G2KA11", "url": "https://omabrowser.org/oma/group/A0A0G2KA11/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KA11", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KA11" } ], "pmid": "" }, { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KA11", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KA11" } ], "pmid": "" }, { "name": "protein serine/threonine kinase inhibitor activity", "id": "GO:0030291", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030291", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KA11", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KA11" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KA11", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KA11" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "G protein-coupled receptor signaling pathway", "id": "GO:0007186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007186", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KA11", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KA11" } ], "pmid": "" }, { "name": "adult locomotory behavior", "id": "GO:0008344", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008344", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KA11", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KA11" } ], "pmid": "" }, { "name": "negative regulation of TOR signaling", "id": "GO:0032007", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032007", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KA11", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KA11" } ], "pmid": "" }, { "name": "dendrite morphogenesis", "id": "GO:0048813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048813", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KA11", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KA11" } ], "pmid": "" }, { "name": "phosphatidylinositol 3-kinase/protein kinase B signal transduction", "id": "GO:0043491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043491", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2KA11", "url": "https://www.uniprot.org/uniprotkb/A0A0G2KA11" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1404, "end_pos": 1406, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1442, "end_pos": 1444, "annotation": "n_glycosylation_sequon" }, { "start_pos": 230, "end_pos": 232, "annotation": "n_glycosylation_sequon" }, { "start_pos": 56, "end_pos": 58, "annotation": "n_glycosylation_sequon" }, { "start_pos": 707, "end_pos": 709, "annotation": "n_glycosylation_sequon" }, { "start_pos": 847, "end_pos": 849, "annotation": "n_glycosylation_sequon" }, { "start_pos": 955, "end_pos": 957, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A0G2KA11-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 1573, "overlap": "1.0", "method": "AlphaFold", 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