{ "uniprot_canonical_ac": "A0A0G2K7F0-1", "uniprot_ac": "A0A0G2K7F0", "uniprot_id": "A0A0G2K7F0_RAT", "mass": { "chemical_mass": 225106.0, "monoisotopic_mass": 225106.0 }, "refseq": { "ac": "NP_001414592", "name": "Fanconi anemia group M protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001414592" }, "gene_names": [ { "name": "Fancm", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K7F0", "id": "A0A0G2K7F0" }, { "name": "Fancm", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001414592", "id": "NP_001414592" }, { "name": "RGD1307897", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001414592", "id": "NP_001414592" } ], "protein_names": [ { "name": "RNA helicase", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K7F0/entry#names_and_taxonomy", "id": "A0A0G2K7F0" }, { "name": "3.6.4.13", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K7F0/entry#names_and_taxonomy", "id": "A0A0G2K7F0" }, { "name": "ATP-dependent RNA helicase FANCM", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K7F0/entry#names_and_taxonomy", "id": "A0A0G2K7F0" }, { "name": "Fanconi anemia group M protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001414592", "id": "NP_001414592" }, { "name": "Fanconi anemia, complementation group M", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001414592", "id": "NP_001414592" } ], "function": [ { "annotation": "DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX. In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates. In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA.", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7F0", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K7F0#function" }, { "database": "UniProtKB", "id": "ARBA00058282", "url": "https://www.uniprot.org/uniprotkb/ARBA00058282#function" } ] } ], "disease": [ { "disease_id": "DOID:0050865", "recommended_name": { "id": "DOID:0050865", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050865", "name": "tongue squamous cell carcinoma", "description": "A head and neck squamous cell carcinoma that is located_in the tongue." }, "synonyms": [], "unlinked_id_list": [], "evidence": [ { "id": "0050865", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050865" } ] }, { "disease_id": "DOID:0080872", "recommended_name": { "id": "DOID:0080872", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080872", "name": "primary ovarian insufficiency 15", "description": "A primary ovarian insufficiency that is characterized by onset of oligomenorrhea in the third decade of life, with small ovaries, reduced number of follicles, and elevated gonadotropic hormones and that has_material_basis_in homozygous mutation in the FANCM gene on chromosome 14q21." }, "synonyms": [ { "id": "MONDO:0054862", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0054862", "name": "premature ovarian failure 15", "description": "" }, { "id": "MONDO:0054862", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0054862", "name": "premature ovarian failure 15", "description": "" }, { "id": "MONDO:0054862", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0054862", "name": "POF15", "description": "" }, { "id": "MIM:618096", "resource": "MIM", "url": "https://www.omim.org/entry/618096", "name": "Premature ovarian failure 15", "description": "Premature ovarian failure 15" } ], "unlinked_id_list": [], "evidence": [ { "id": "0080872", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080872" } ] }, { "disease_id": "DOID:0111916", "recommended_name": { "id": "DOID:0111916", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111916", "name": "spermatogenic failure 28", "description": "A spermatogenic failure characterized by nonobstructive azoospermia and a Sertoli cell-only phenotype in testes that has_material_basis_in homozygous or compound heterozygous mutation in the FANCM gene on chromosome 14q21.2." }, "synonyms": [ { "id": "DOID:0111916", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111916", "name": "SPGF28", "description": "" }, { "id": "MONDO:0054732", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0054732", "name": "spermatogenic failure 28", "description": "" }, { "id": "MONDO:0054732", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0054732", "name": "spermatogenic failure 28", "description": "" }, { "id": "MONDO:0054732", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0054732", "name": "SPGF28", "description": "" }, { "id": "MIM:618086", "resource": "MIM", "url": "https://www.omim.org/entry/618086", "name": "Spermatogenic failure 28", "description": "Spermatogenic failure 28" } ], "unlinked_id_list": [], "evidence": [ { "id": "0111916", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0111916" } ] }, { "disease_id": "DOID:13636", "recommended_name": { "id": "DOID:13636", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13636", "name": "Fanconi anemia", "description": "A congenital hypoplastic anemia characterized by progressive pancytopenia with bone marrow failure, variable congenital malformations and predisposition to develop hematological or solid tumors. It is a result of a genetic defect in a cluster of proteins responsible for DNA repair." }, "synonyms": [ { "id": "DOID:13636", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13636", "name": "Fanconi anaemia", "description": "" }, { "id": "DOID:13636", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13636", "name": "Fanconi pancytopenia", "description": "" }, { "id": "DOID:13636", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13636", "name": "Fanconi panmyelopathy", "description": "" }, { "id": "DOID:13636", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13636", "name": "Fanconi's anaemia", "description": "" }, { "id": "DOID:13636", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:13636", "name": "Fanconi's anemia", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "Fanconi anemia complementation group A", "description": "Fanconi anemia caused by mutations of the FANCA gene. FANCA gene mutations are the most common cause of Fanconi anemia. This gene provides instructions for making a protein that is involved in the Fanconi anemia (FA) pathway." }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "FANCA", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "FANCA Fanconi anaemia", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "FANCA Fanconi anemia", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "Fanconi Anemia, complementation group type a", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "Fanconi anaemia caused by mutation in FANCA", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "Fanconi anaemia complementation group type A", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "Fanconi anemia caused by mutation in FANCA", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "Fanconi anemia complementation group A", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "Fanconi anemia complementation group type A", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "Estren-Dameshek variant of Fanconi Anaemia", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "Estren-Dameshek variant of Fanconi Anemia", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "Estren-Dameshek variant of Fanconi pancytopenia", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "Fanconi Anaemia", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "Fanconi Anemia", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "Fanconi Anemia, Estren-Dameshek variant", "description": "" }, { "id": "MONDO:0009215", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009215", "name": "Fanconi anemia, complementation group A", "description": "" }, { "id": "MIM:227650", "resource": "MIM", "url": "https://www.omim.org/entry/227650", "name": "Fanconi anemia, complementation group A", "description": "Fanconi anemia, complementation group A" } ], "unlinked_id_list": [], "evidence": [ { "id": "13636", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:13636" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7F0", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K7F0" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "gene": [ { "name": "Fancm", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K7F0", "locus": { "chromosome": "6", "start_pos": 83180028, "end_pos": 83127093, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000056721", "url": "https://www.ensembl.org/id/ENSRNOG00000056721" } ] } } ], "crossref": [ { "id": "RGD:1307897", "url": "https://alliancegenome.org/gene/RGD:1307897", "database": "AGR", "categories": [ "Protein Classification" ] }, { "id": "A0A0G2K7F0", "url": "https://alphafold.ebi.ac.uk/entry/A0A0G2K7F0", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSRNOG00000056721", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000056721", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12091", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12091", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18033", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18033", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18801", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18801", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20077", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20077", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "314172", "url": "https://www.ncbi.nlm.nih.gov/gene/314172", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001650", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001650", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006166", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006166", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010994", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010994", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011335", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011335", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011545", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011545", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014001", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014001", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031879", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031879", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039686", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039686", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044749", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044749", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047418", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047418", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "MQMLPND", "url": "https://omabrowser.org/oma/group/MQMLPND/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR14025", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14025", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14025:SF20", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14025:SF20", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00270", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00270", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00271", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00271", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02732", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02732", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF16783", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16783", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-6783310", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6783310", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9833482", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001414592", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001414592", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1307897", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1307897", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "13065", "url": "https://www.rhea-db.org/rhea/13065", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A0G2K7F0", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K7F0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2K7F0-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K7F0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1W2Q6G5", "url": "https://www.uniprot.org/uniprotkb/A0A1W2Q6G5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1W2Q6G5-1", "url": "https://www.uniprot.org/uniprotkb/A0A1W2Q6G5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSGRQRTLFQTWGPSLVRGAGAPGCGQPRSPAVTESLPEEDDEVLLVAAYEAEQQLDPGDGGFCAAAGALWIYPTNCPVRDYQLDISRTALFCNTLVCLPTGLGKTFIAAVVMYNFYRWFPSGKVVFMAPTKPLVTQQMEACFHVMGIPQSHMAEMTGSTQAVNRKEIWSSRRVLFLTPQVMVNDLTRGAVPAAHVKCLVVDEAHKALGNYAYCQVVRELVKYTNHFRILALSATPGSDIKAVQQVITNLLIEKIELRSEDSPDILPYSHERRVEKLVVPLGEELGAIQKTYVQILETFASSLIKRNILMKRDIPNLTKYQIILARDQFRKNPSPNIVGVQQGIIEGELAICISLYHGYELLQQLGMRSLYFFLSGIMDGTKGMTRVKTELSRNEDFTKLYSHLQSVFAHVRDAAAASEASAFQKGNKEKKFVYSHPKLKKLEEVILEHFKSWNAKNTTEKKCQESRVMIFSSFRDSVEEIAEMLSQHQPGVRVMTFVGHASGKNTKGYTQKEQLRVVRQFRDGGYNTLVSTCVGEEGLDIGEVDLIICFDAQKSPIRLIQRMGRTGRRRQGRIVVILAEGREERTYNQSQSNKKNIYKAISGNRQVLRLYQGSPRMVPDKINPELHKMFITHGVYESEKARSVQRKSFSSRSGIKAGNSNKDGLLSEEEFNLWNRLYRLGDSDTVKGVALPRSHFLSLQEDRVAQEPTTGIHQLSLSEWSLWQDHPLPTHQVEHSDRCHHFISIMRMIEGMRHEEDECSYELKIKPFLQMEDVYSKYNAPRNGYKNVASVTRIAPKKSSFRPSVDAGGSLSVTESEEGCADTVEQMDSEWTKITSLREKATTVGKGQTREQTDDDHDDADSSDSDRNSPADVVSRVPPSGERVADVGGIPILGAVTEDDSHTGTLLMECQVTEKSLARYSLDSGYSSFSDDKSLSSHLFLPLEEELYTERAAELFYRCQPMTEEVLANVEKFLSHSPPSLSGLSDVEYAVTQGFELDNESCLPYPEREHSPKPGSPYPEREHSPKPASLALYTAVNSQSNLELNSAKHTNPPSEKDCLPATTHNNIPDQPSFCDSDSETHNIKNQNLVSNSYGQIQVNLENNLVDENSHDDSEPPVLFTDEDESLLLFEDDLKNIEDGTEELNGVGLPPLDRISQPLCVSDKTLISEMPPVSHFLISDELLDDDSEPEDQIICDTKCWEGVEGRDEEIKTEGQPFDCSADLFSVTFDLGFCSSGSDDENPARASDRSSTLGTAEVPGRHSDKEVKDASHASGPLGGTISPIPSEKMPWSPCAQSKECAPFHSALSLPVRERAMSTPLSKAHRSSKTGAHVLKTLDSTKEKAGGQGFKVTLNPRFDNLGFSVEETKSSDQLSVYQSPRCPKVEHLTSESEDDVFLKKTRKPKGNVLKSPEDQKNNEVDSPIHVVKKSRVLRSELSSSDDESENFHRPCPKLEYFKDRNRNTRKGSKAQKKRIHMKALARGFLDEEAEVSGEDADCVSSDEGDDSENEKDSSLLDFVNDRTQLSQAINDSEMRAIYMKSVRSPLMSTKYKMVREKHNSMNIFSQIPEQDENYLEDSFCVAEEESCRSQSSEEEIFVDFNLTKDSFTDEDIRYKTRHAVKLKQMNKKQNCTRSRKKLSRIILPDSDSSEEENTANGREDPSAGGHAADKHTQQGQLWASGPSGSVQPKVLCNPAGNQSSGQRLQVLPNIMDAVPGALNVRAQSHNQTKSTSPPCASVESRKECGNRPVQLKVGDQDTSAAPCSASLLPDAEVLIAPRHPREGNRACILVDSREITTGLEVISSLRTVHGLQVEICPLNGCDYIVSNRMVVERKSQSEMLSNTAKNKFIEQIQRLQSMFQRICVIVEKDREKAGDISKMFRRTKCYDSLLTALVGAGIRILFSSGQEETAGLIKELSLVEQRKNAGIHIPAVLDTGTCEALQFYLSIPGVSYVTALNMCHQFSSVKKMVNSSPEEISTCAQVTHQKAEEIYKYIHYTFDMQMLPNDLTQERQKSETCSTL", "length": 2017, "header": "tr|A0A0G2K7F0-1|A0A0G2K7F0_RAT Isoform 1 of RNA helicase OS=Rattus norvegicus OX=10116 GN=Fancm PE=3 SV=1 CANONICAL=A0A0G2K7F0-1" }, "isoforms": [ { "isoform_ac": "A0A0G2K7F0-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K7F0/entry#A0A0G2K7F0-1", "sequence": { "sequence": "MSGRQRTLFQTWGPSLVRGAGAPGCGQPRSPAVTESLPEEDDEVLLVAAYEAEQQLDPGDGGFCAAAGALWIYPTNCPVRDYQLDISRTALFCNTLVCLPTGLGKTFIAAVVMYNFYRWFPSGKVVFMAPTKPLVTQQMEACFHVMGIPQSHMAEMTGSTQAVNRKEIWSSRRVLFLTPQVMVNDLTRGAVPAAHVKCLVVDEAHKALGNYAYCQVVRELVKYTNHFRILALSATPGSDIKAVQQVITNLLIEKIELRSEDSPDILPYSHERRVEKLVVPLGEELGAIQKTYVQILETFASSLIKRNILMKRDIPNLTKYQIILARDQFRKNPSPNIVGVQQGIIEGELAICISLYHGYELLQQLGMRSLYFFLSGIMDGTKGMTRVKTELSRNEDFTKLYSHLQSVFAHVRDAAAASEASAFQKGNKEKKFVYSHPKLKKLEEVILEHFKSWNAKNTTEKKCQESRVMIFSSFRDSVEEIAEMLSQHQPGVRVMTFVGHASGKNTKGYTQKEQLRVVRQFRDGGYNTLVSTCVGEEGLDIGEVDLIICFDAQKSPIRLIQRMGRTGRRRQGRIVVILAEGREERTYNQSQSNKKNIYKAISGNRQVLRLYQGSPRMVPDKINPELHKMFITHGVYESEKARSVQRKSFSSRSGIKAGNSNKDGLLSEEEFNLWNRLYRLGDSDTVKGVALPRSHFLSLQEDRVAQEPTTGIHQLSLSEWSLWQDHPLPTHQVEHSDRCHHFISIMRMIEGMRHEEDECSYELKIKPFLQMEDVYSKYNAPRNGYKNVASVTRIAPKKSSFRPSVDAGGSLSVTESEEGCADTVEQMDSEWTKITSLREKATTVGKGQTREQTDDDHDDADSSDSDRNSPADVVSRVPPSGERVADVGGIPILGAVTEDDSHTGTLLMECQVTEKSLARYSLDSGYSSFSDDKSLSSHLFLPLEEELYTERAAELFYRCQPMTEEVLANVEKFLSHSPPSLSGLSDVEYAVTQGFELDNESCLPYPEREHSPKPGSPYPEREHSPKPASLALYTAVNSQSNLELNSAKHTNPPSEKDCLPATTHNNIPDQPSFCDSDSETHNIKNQNLVSNSYGQIQVNLENNLVDENSHDDSEPPVLFTDEDESLLLFEDDLKNIEDGTEELNGVGLPPLDRISQPLCVSDKTLISEMPPVSHFLISDELLDDDSEPEDQIICDTKCWEGVEGRDEEIKTEGQPFDCSADLFSVTFDLGFCSSGSDDENPARASDRSSTLGTAEVPGRHSDKEVKDASHASGPLGGTISPIPSEKMPWSPCAQSKECAPFHSALSLPVRERAMSTPLSKAHRSSKTGAHVLKTLDSTKEKAGGQGFKVTLNPRFDNLGFSVEETKSSDQLSVYQSPRCPKVEHLTSESEDDVFLKKTRKPKGNVLKSPEDQKNNEVDSPIHVVKKSRVLRSELSSSDDESENFHRPCPKLEYFKDRNRNTRKGSKAQKKRIHMKALARGFLDEEAEVSGEDADCVSSDEGDDSENEKDSSLLDFVNDRTQLSQAINDSEMRAIYMKSVRSPLMSTKYKMVREKHNSMNIFSQIPEQDENYLEDSFCVAEEESCRSQSSEEEIFVDFNLTKDSFTDEDIRYKTRHAVKLKQMNKKQNCTRSRKKLSRIILPDSDSSEEENTANGREDPSAGGHAADKHTQQGQLWASGPSGSVQPKVLCNPAGNQSSGQRLQVLPNIMDAVPGALNVRAQSHNQTKSTSPPCASVESRKECGNRPVQLKVGDQDTSAAPCSASLLPDAEVLIAPRHPREGNRACILVDSREITTGLEVISSLRTVHGLQVEICPLNGCDYIVSNRMVVERKSQSEMLSNTAKNKFIEQIQRLQSMFQRICVIVEKDREKAGDISKMFRRTKCYDSLLTALVGAGIRILFSSGQEETAGLIKELSLVEQRKNAGIHIPAVLDTGTCEALQFYLSIPGVSYVTALNMCHQFSSVKKMVNSSPEEISTCAQVTHQKAEEIYKYIHYTFDMQMLPNDLTQERQKSETCSTL", "length": 2017, "header": "tr|A0A0G2K7F0-1|A0A0G2K7F0_RAT Isoform 1 of RNA helicase OS=Rattus norvegicus OX=10116 GN=Fancm PE=3 SV=1 CANONICAL=A0A0G2K7F0-1" }, "locus": { "chromosome": "6", "start_pos": 83179791, "end_pos": 83127167, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000086081.2", "url": "https://www.ensembl.org/id/ENSRNOT00000086081.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000074177.1", "url": "https://www.ensembl.org/id/ENSRNOP00000074177.1" } ] } }, { "isoform_ac": "A0A1W2Q6G5-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K7F0/entry#A0A1W2Q6G5-1", "sequence": { "sequence": "MGSRGFLDEEAEVSGEDADCVSSDEGDDSENEKDSSLLDFVNDRTQLSQAINDSEMRAIYMKSVRSPLMSTKYKMVREKHNSMNIFSQIPEQDENYLEDSFCVAEEESCRSQSSEEEIFVDFNLTKDSFTDEDIRYKTRHAVKLKQMNKKQNCTRSRKKLSRIILPDSDSSEEENTANGREDPSAGGHAADKHTQQGQLWASGPSGSVQPKVLCNPAGNQSSGQRLQVLPNIMDAVPGALNVRAQSHNQTKSTSPPCASVESRKECGNRPVQLKVGDQDTSAAPCSASLLPDAEVLIAPRHPREGNRACILVDSREITTGLEVISSLRTVHGLQVEICPLNGCDYIVSNRMVVERKSQSEMLSNTAKNKFIEQIQRLQSMFQRICVIVEKDREKAGDISKMFRRTKCYDSLLTALVGAGIRILFSSGQEETAGLIKELSLVEQRKNAGIHIPAVLDTGTCEALQFYLSIPGVSYVTALNMCHQFSSVKKMVNRKRQPAERFLCVYSFKADRSALDK", "length": 516, "header": "tr|A0A1W2Q6G5-1|A0A1W2Q6G5_RAT Computationally mapped isoform of FA complementation group M OS=Rattus norvegicus OX=10116 GN=Fancm PE=4 SV=2 CANONICAL=A0A0G2K7F0-1" }, "locus": { "chromosome": "6", "start_pos": 83177096, "end_pos": 83166147, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000093492.2", "url": "https://www.ensembl.org/id/ENSRNOT00000093492.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000076245.2", "url": "https://www.ensembl.org/id/ENSRNOP00000076245.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "start_pos": 235, "start_aa": "Thr", "end_pos": 235, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr235", "evidence": [ { "id": "GLY_001157", "database": "GlyGen", "url": "https://data.glygen.org/GLY_001157" } ], "filter_code": "00000000000000001000.00000000001000.0.xxxxx" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "R-RNO-6783310", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6783310", "resource": "Reactome", "description": "Fanconi Anemia Pathway" }, { "id": "R-RNO-9833482", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9833482", "resource": "Reactome", "description": "PKR-mediated signaling" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0D5W690-1", "protein_name": "RNA helicase", "gene_name": "rigi", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MYELEKENLRRLSSYITAIIRPSLIKTFMTTYLKKETVERIMSTEQSSPSAAAQMLLDCMCDLEEDGWFQAFLDFLLTAEYSGLHDAIKNWNFLEYEELHEHRKLLERIEPSITKHLKPRELLMHMNCCLNQRESEEIQAVEAQRGPIAASEKLVDCLLRSDKSNWFKVLKMALDTCELYEALDLLETDGAGKSVQDSDCMMAESSTVCFEYREEMETENMAAPESCSHMSITETPAGVTGDSGRSGKRKLREYQRELMTAAVNGQNTIICAPTGCGKTIVALGICEEHLKLLRGRAKIAFLATKVDVYEQQYKLFQEHFSSKDPNIRVTGMCGDMALSVRMLIETHDIVVLTAQILVNALQSGEMENLQLLTLILLDECHNTTGKHPYNNIMTRYLDSKLTGNGSPLPQIVGLTASVGIGSFKNQMEAENNVTQLCANMDTRVITTVSKHLDELRSYVHTPEKEFFHVFQSPSDPFIRIIQNIMSNIEQMAKKTYNIESLSNISNREYGSQKYEQWIVSVQKSCRVLQMQNADGERRICRELCNYTEHLRKYNDALIINEDARTIDALDYLDVFFQQVRNAGFQTTERKLTALYDTQRPQLQCLATEGQQNPKLEELRFILEEEYHNNQETRTVMFVRTRALADAMKKWIDDTDTLKFLKPGVLIGKGRKSNFTGSGMTPSNQRGVLDTFKSSDQSKMLIATSVADEGIDIPQCNLVLMYEYVGNVVKMVQVRGRGRAQGSRCFLISSSAERIEKEKMNMMKERLVEAAIVALQSRPADLSFKVDILQKEDKARRDFLSASPDKPKTQDSFKLLCAKCKMFACQSDDLRVVQESHHIVVDRSIFSRCSRVPHRKPINFCGFSKKEKMLCVECKHDWGLVVSYLTIQDLPLLKIESFVVQNLVTGEQHYFRKWCKVTFAIREFDMTEITPETWALVN", "length": 937 }, "evidence": [ { "id": "SGD:S000001441", "url": "https://alliancegenome.org/gene/SGD:S000001441#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A0E3D804-1", "protein_name": "RNA helicase", "gene_name": "ifih1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDPNMSSDQDTETRHILDCFRDRLKRLIQVEPLLDLLDFLEPDKKERIKAKVASEGNINAVSLLINEIMRAELQQGWSRTLVTALETVGCGHAARYVRNRPPEPDEEAEHDSCVRLIDLLHLSLVNMKTRDVCVQCVTLGLLTQEDQENIMTATGNNGNINGARLLLKRLVKNEAGWFSKFLQALEDTEHRDLMRELRGEPCEGDEGMSVDSSDAQAEVKDTGAVRRNSMSSPPPSFTPNSSLQSEDLDDSVDSSVLGVEAGNRGVEMYEDGEEKEEKDLKEDEDDDSSASKREIKLRDYQMEVARPALEEKNIIVCLPTGSGKTRVAVFITKEHLEREQRMGQKGKVVVLVNKVPLVEQHYKAEFGRFLKHQYSVERVSGASQLKISFPQIIEKNDIIICTAQILENSLAKAKNGDEDGIELSQFTLMVIDECHHTKKGGVYNHIMIRYLEQKNRNQLLKKQDKTLVPIPQILGLTASPGVGGAVSQQMAEEHILQICANLDAFTIKTKTFEEEEAKTPFKRIAKAEERKEDPFGDVIKKIMDEIHTHADLQPLCEPGTQNYEQWVVQKGQNAAKEENQNVRVCAEHLRQYNEALHQSNTIRMSDAFRFLDKYHNEELKTKSSPDEEGNITITDTERFLFTLFKDKKAKLQELMGKPQYENNNLAQLKTIILKEFCTREKARGIIFTQTRLSAIALCQWIEENPKFDEVGVQASYLIGGGDQSVVKPMTAAEQKDVLKRFRTGEINLLIATTVAEEGLDIAECNVVIRYCLVTNEVAMIQARGRGRAEDSSYTLVAEAGSGVAERESVNEYREKMMSKAIAKVCKMNRADYEKKIMEFQIQAIMEEKVKTKKKQQKGMMKEAPSKIRLSCRQCSVFVCSGEDIEIIEKMHHVNVTKQFRKLFIVRENASLQERLLDYETNGVIACKKCGQQWGSMMLYRSTECPCLHIKNFVVTYGSKKKTFSKWRELSISFPAFDYTQHADLLVEDSEDEDMDTN", "length": 997 }, "evidence": [ { "id": "SGD:S000001441", "url": "https://alliancegenome.org/gene/SGD:S000001441#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A3Q1LT80-1", "protein_name": "RNA helicase", "gene_name": "FANCM", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MSGRQRTLFQTWGSKVSRSTGAPTCNSGTERPQSTGISRARFPAVAEAAGAAEVEPESDDDVLLVAVYEAERQLNLENGGFCTSAGALWIYPTNCPVRDYQLHIARTALFCNTLVCLPTGLGKTFIAAVVMYNFYRWFPSGKVVFMAPTKPLVTQQIEACYRVMGIPQSHMAEMTGSTQAFTRKEIWSSKRVLFLTPQVMVNDLSRGACPAAEIKCLVIDEAHKALGNYAYCQVVRELVKYTNHFRVLALSATPGSDIKAVQQVITNLLIGQIELRSEDSPDILPYSHERRVEKLVVPLGEELEAIQKAYIQILEAFASSLIQRNVLMRKDIPNLTKYQIILARDQFRKNPSPNIVGIQQGIIEGEFAICISLYHGYELLQQMGMRSLYFFLCGIMDGTKGMTRAKNELSRNADFMKLYDHLDSMFSHTRSTSTSGVSAIQKGGKDKKFCYSHPKLKKLEEVVVEHFKSWNARKTSDKKCDETRVMIFSSFRDSVQEIAEMLLPHQPIIRVMTFVGHASGKSMKGFTQKEQLEVVKQFRSGGYNTLVSTCVGEEGLDIGEVDLIICFDAQKSPIRLIQRMGRTGRKRQGRIVVILAEGREERTYNQSQCNKRSIYKAISGNRQVLHFYQGSPRMVPDGVNPQLHKMFITHGVYEPEKPSRNLPRKSSIFSYRNGIKQSNSKDDWFLSEEEFKLWNRRYRLRDTDEIQQITLPQVQFLSLHNEENRPTEEPTVGIRQLSLSEWRLWQDHPLPTYQVDHSDRCHHFINIMQMIEGMRHEEGECSYESEIKSYLRMEDVSSASSALRNEYNSFADGTFTNNRKSSFANINHRKSVSMTESDEECTEIFKQIPIKSTKIPSLKKKASENLKKDQPKKENKDVVMEPLDTDDSPTTEHILQVDPRNGERVSDTGEVTATCAVSENGGNPSCGLLTDCQFTIKSTGSFTGSFFDSGYNSFSDEKSFSASLFLSFEGELDIAKTDDQFFHCHSLTKEVLANVERFLSHSPPPLSGLSDLENEISEGSALENLVFLPYSECLQNDKSTNLMACSAVNSQQNLKFITHLSEKTCIYGTTNDKISDEPSFCDSDKVHKDSKNEHLVSSNQIQINISPSKDFAEEKNHDVDNSDLPILHTAQDESLLLFEDVNTEFNDVSPPPLNSKCESLGISDRTAVSEMAPVSQFFISDELLLENDSEPQDQIVCDTNSWKSHEGLRGRHEGKLNNDENGFDCSKDLFSVTFDLGFCSTGSEDEVVDHASDTNNEILDDLPGRRLDIKQINSTNCVSNQAVMSGAHVDNSTSVTTTHPSSEDKQTPAFSCFSMNATKSKEFMSPSYSQFLLPVGDKVMSTPLSESNILNSFSEKRMEMAKKSGSNMGKVNLHSFKETLNSTFGDSGLSTGKYKSKKQINLHQACHSTEDEQLSTHESEDDEIFRRKSKKTKGNVLESPENQKNSEVDSPLQVVKKHRVPPNRLDLSSSDESDNFHKRDPQSEDFTDHKRNAKRSIKVQKRQNHLKLVARKFLDEEAELSQEDAEYVSSDENDESEGEQDSSLLDFLNDETQLSQAINDSEMRAVYMKSVRSPLMSNRYKMAHKKHNINIFSQIPEQDETYLEDSFCVDEEESCESQSSEEVCVDFNLITEDCDTNESKKYKTRRAVKLKQMKMRQNCARSKNKLSRIILLDDSSEEEKDVKDKQESRTVVNPSTVPPGSSLQSRDHSHPVDNQLLHQRQQTPPNLKVPDSDVSDFKPQSLTNTESASSLFTAVGAQEDCRKFPVQLKGASALQDSGTCVPCCSNSRPRLADTHASLRLPQEGHRTCILVDSREIVSGSEVVSSLRAIHGLQVEVCPLNGCDYIVSNRMVVERRSQSEMLNSINKNKLIDQIQYLQSMFERICVIVEKDREKTGDTSRMFRRTKSYDSLLATLIGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVNSNICETLQFYLSIPNISYITALNMCHQFSSVKKMTNSTPQEISMYAQVTHQKAEEIYRYIHYIFDMQMLPADLNQADLLTQGSNLSF", "length": 2042 }, "evidence": [ { "id": "A0A0G2K7F0", "url": "https://omabrowser.org/oma/group/A0A0G2K7F0/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "A8QLH8-1", "protein_name": "Fanconi anemia M", "gene_name": "fancm", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSGAQRTLFQAWGQSGAPRTRSPQQPEIKPYAAAADDDDDDDDVLLVAVCEAERSAGDLGFDYSAGRVWIYPTNLPLREYQLRVCEAALLQNTLVCLPTGLGKTFIASVLMYNYYRWFPAGKIVFMAPTKPLVAQQIEACYRVMGIPQEHTAELTGSTAAPQRRSLWSSRRVFFLTPPDRCVVIDEAHKATGNHAYCQVIRELRKQTPQFRVLALSATPGGDVKAVQQVISNLLISHIELRSEDSPDVQTHVHQRSLEKMVVPLGESLTHYQTRYLQVLERFSSRLTQMRLLNQRDLRAFSKYQIILAREQFRRNPPPHIQGPQQQGVLEGDFALLISLYHGFELLLQMGIRSLFLFIQNIFTGPRESSRVRNELQRCSLFMDLYREMENMFNTASRGLEEPYVYTHPKLQKLDEVVLRHFQTCAESSDVSAVDTRVMIFSSYRESVQEIAEMLNRHQPLVRVMTFMGQASAGRGVRGFTQKEQLEVVWRFREGGFNTLVSTCVGEEGLDIGEVDLIVCFDAQKSPIRLVQRMGRTGRQRQGRIVVILAEGREERTYNQSQSNRRSINKSIMGNKHSFQMFSDSPRMLPADVTPALHKMHISCAQQFQHRDSGRRSSKSRRSSLTLNMTAGADQRCLKQDWSLSAAEQAVWSSSMRLSETEAQPVFRPSSMLSFNEERAPLCGSGVCVSGECVCVSRPLRELSLWEWRHWQNRPLHTHRVQHSERCLHFTTIMELIDTLRHQEEEGDCSVQSELMKHLQMEDIDGGQTSTNNRTASSTEEQRNATPAAHTPGALLQVQECVSISDGVDDDVQTCSAAAHECVECLLDGQEDESSDLQHIFYQPELQKPKRCRHSLNSRRFLEIIRNVEQMLCRSPPKLLEEEEPLTEGFRVSFSLTSALGDPDEDDEDTGVCAQSTAPSAAAAGSPGWDELFDDALLEDGDGFMKAEERQEDQLSLDLFDDEDFLQMSMPDVQTPDNSTGPEGEQPEEKHQTLADVSGERSTLTGPEGEQQAPPNVSGSRLNITGPDGEHSEQKHWTLADCSRRSSITGPDGEQVTPVSVSGSRLNLTGPEGEQRTPVNVTQGRSNLTGPEGKQETEGSRSRSSLTGPEGEQESPVNVTGSRSNLTGPEGEQAAGGSGSSCVFRCSQDFFSVNFGLGFESESEEEAAAGASVSGLTSDLPPLTSDLCSAAPQPSASTPNHLYLSAHRRTHTPIQRRRTCAGVFVSDSEDETHHQRFPALELAPVFSPEVKQQQQQEVSSDVDSPLQVCRKRTATLNTSEDSDGDDVLQLISVHQSGRHRSIKKFPRGAARQFLDEEAELSEDEDGDVSSDEDDGDEQNQSLQGFVVNNTQCSQGLNDSEMQAFYLKSVRSPALQKPVRMTFKPKHNLNIFSQVPEQDESYAEDSFVVDGSEEEDEVSADEESVELIPEDSFIDGRRQYATRRRARIRQIRAANPATDQQRKNKRSRIIRPQDSSDEDEDQPQTHTVFKVPQSVCRRPEPEIQKRQRLEDQAELSEELDFQTHKQAPDAGFPVSADAPLAVLVDARCISGGSELLSLLRIRHHLQVHVCSLGSTDFIVSNRTAVEWQSESEVSSAHNRRRLQERMQRLQATYERVCLIIQKDRTRPGETVRVFQRSRYYDSTLAALVTAGVRLLFSNGFDETATILTDLTQVEKRKGQAIQVPLEVKGHRQQALQFYLTLPNMSYICALNMSHRFSSISHMISSSVEDLQASACVSRSRAEEIYRCLRYSCDPVLINQTNQT", "length": 1761 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-090929-1", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-090929-1#orthology", "database": "AGR" }, { "id": "RGD:1307897", "url": "https://alliancegenome.org/gene/RGD:1307897#orthology", "database": "AGR" }, { "id": "MGI:2442306", "url": "https://alliancegenome.org/gene/MGI:2442306#orthology", "database": "AGR" }, { "id": "SGD:S000001441", "url": "https://alliancegenome.org/gene/SGD:S000001441#orthology", "database": "AGR" }, { "id": "HGNC:23168", "url": "https://alliancegenome.org/gene/HGNC:23168#orthology", "database": "AGR" }, { "id": "FB:FBgn0038889", "url": "https://alliancegenome.org/gene/FB:FBgn0038889#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "D3ZD46-1", "protein_name": "RNA helicase", "gene_name": "Dhx58", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MELRPYQWEVILPALEGKNIIIWLPTGAGKTRAAAFVAKRHLETVDRGKVVVLVNRVHLVNQHAEEFRRMLDKQWTVTTLSGDMGSRAGFGLLARSHDLLICTAELLHLALKSSEEDEHVELTEFSLIVVDECHHTHKDTIYNTILSRYLEHKLKKAKPLPQVLGLTASPGTGGATKLQGAIDHILQLCANLDTWRIMSPKNCYSQLLEHNPKPCKQYDLCQRRTQDPFGDLLKKLMKQIHQQLEMPDLKQQFGTQMYEQQVVQLSKDAAEAGLQEQRVYALHLRRYNDALYIHDTVRAWDALNMLQDFYDTERALKTQMVHAERWLLELFDDHRKALAQFAAQGPENPKLEMLEGILLKQFGSPDHTRGIIFTRTRQTASSLLLWLRQQPCLQTVNIKPQMLIGAGNTGQSTHMTQKDQQEVIQEFRDGKLNLLVATSVAEEGLDIAQCNVVVRYGLLTNEISMVQARGRARAGQSVYSFVATEGSREIKRELTNEALEVLMEQAVAAVQKMDPEEFKAKIQDLQLASLVKRAARAAHRESQQGQFPPDRVQLLCINCMVAVGYGSDLRKVEGTHHVNVNPDFSVYYTTSQNPVVINKVFKDWKPGGIIRCSNCGEVWGFQMIYKSVTLPVLKIRSMLLETPHGKIQAKKWSRVPFSVPDFDILRDCTQSLSDLSLD", "length": 678 }, "evidence": [ { "id": "SGD:S000001441", "url": "https://alliancegenome.org/gene/SGD:S000001441#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D4ADT5-1", "protein_name": "Antiviral innate immune response receptor RIG-I", "gene_name": "Rig1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTAEQRQNLQAFRDYIKKILDPTYILSYMSSWLRDDEVQCIQAEKNNKGPIEAASLFLRYLLELQTEGWFRAFLDALYHAGYCGLYEAIETWDFQKLEKLEEHRLLLRRLEPEFKATVSPTDILSEISECLINQECEEIRQICFTKGRMAGAEKMVQCLLRSDKENWPKVLQFALEKDNSKFSELWLVDKGVRRVDCKAVEDDGTEMASIQIFIQEEPECQNLSQNPGPPSEASPNNSHSPLKPRNYQLELALPAKKGKNTVICAPTGCGKTFVSLLICEHHLKNFPHGQKGKVVFFANQIPVYEQQATVFSRYFERFGYNVAGISGATADNVSVQHIIENNDIVILTPQILVNSLNNGAIPSLSVFTLMIFDECHNTSKHHPYNQIMFRYLDHKLGGSPDPLPQVIGLTASVGVGDAKTVEEAMLHICKLCAALDASVIATVRDNVEELEQVVYKPQKISRKVESRASNTFKCIISQLMREAERLAKNVSEELGKFFQIQNREFGTQKYEQWIVAVHKACTVFQMPDKDEESRICKALFLYTSHLRKYNDALIISEDAQMKDALNYLKAFFHDVREAAFDETEQDLTRRFEEKLEELENVSRDPSNENPKLRDLYLILQEEYHLKPETKTILFVKTRALVDALKKWIEENPALSFLKPGILTGRGRTNQATGMTLPAQKCVLEAFRANADNNILIATSVADEGIDIAQCNLVILYEYVGNVIKMIQTRGRGRARDSKCFLLTSSADVIEKEKANMVKEKIMNESILRLQTWDEVKFQKTVHRIQLDEKLLRDSQHKPQPVPDRENKKLLCGKCKTFACYTADIRVVEKSHYTVLGDAFKERFVCKPHPKPKIYDSFEKKAKIFCAKQNCSHDWGIFVRYKTFEIPVIKIESFVVEDIESGVQNRHSKWKDFHFERKQFNPEEMST", "length": 926 }, "evidence": [ { "id": "SGD:S000001441", "url": "https://alliancegenome.org/gene/SGD:S000001441#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F1QUY3-1", "protein_name": "RNA helicase", "gene_name": "dhx58", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MELRLRPYQEEVVQAALRGENSIIWLPTGGGKTRAAVYVAEKHLETKANAKVAVLVNKVHLVDQHYMKEFGHYLRHKYRIKAISGDSSEKDFFGRLVRVSDLVICTAQILENALNNMDEDKHVEITDFTLLVIDECHHTNKESVYNKIMWRYVEKKVRKEGRLPQILGLTASPGTGGNKSLDKAVEHVLQICANLDSKIVSTKNYTPMLQNFVPKPKKEYDIVERRDKDPFGDHLKSMMLMIHEFMPPTVSRGLRELGTQEYEADVVELEKAGVKVNNRLIAQCALHLRKYNDALLINDTIRMVDAFRVLEEFYNSRSSKLLDGTDIFLQGLFDENSLELKHLASDARYENPKLAQLQSRLLEEFQDTNSRGIIFSKTRRGTHCLNDWVKTNRELQRVNITAGILTGAGNGANNMTQTEQKSVISHFRQGYLNLLISTSVAEEGLDIPECNLVVRYGLLTNEIAQQQASGRARASNSVYSVVADVGGREVRKELVNEYLEDLTARAIDEVQRMSPVDFRHKVFELQKTAVVIRMEAERKRDAKKQRYSPGQVQLQCRSCFASVCSGGDIRKIENSHHVNVNTEFKNHYKVGDQVNMERTFEDWEPGRIISCRKCKKDWGFEIKFKKVAILPCLKIKSFSFNTPKETKPYKKWKDVEFQVTEFDFIEYMSCRFPDLDLSD", "length": 679 }, "evidence": [ { "id": "SGD:S000001441", "url": "https://alliancegenome.org/gene/SGD:S000001441#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "G3V6W5-1", "protein_name": "Interferon-induced helicase C domain-containing protein 1", "gene_name": "Ifih1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSTVCSAEDSFRNLISIFRPRVKMNIQVEPVLDYLVFLPAETKEQILRKVTTCGNTSAAELLLSTLEQGQWPLGWTQMFVEALEHSGNPLAARYVKPSLTDLPSPSSETAHDECLHLLNLLQPTLVGKLLINDVLDTCSEKGLVTVEDRNRISAAGNSGNESGVRELLRRIVQKENWFSTFLDVLRQTGNDALVQELTGVSCPEESTDLDNASHKDRPAANEPLLPAIDALSLETEAWTIEDTSPEASFADSSVTTESDTSLAEGSVSCFDESLGHNSNMGRDSGTMGSDSDEDTIMGTKRASPKPELQLRPYQMEVAQPALDGKNIIICLPTGSGKTRVAVYITKDHLDKKKQACESGKVIVLVNKVMLAEQLFRKEFNPFLKKWYRIIGLSGDTQLKISFPEVVKSYDVIISTAQILENSLLNLESGEDDGVQLSDFSLIIIDECHHTNKEAVYNNIMRRYLKQKLKNHKLKKQNKPTIHLPQILGLTASPGVGAAKKQSEAEKHILNICANLDAFTIKTVKENLSQLKHQIKEPCKKFVIADDTRENPFKEKLLEIMASIQTYCQKSPLSDFGTQHYEQWAIQMEKKAAKDGNRRDRVCAEHLRKYNEALQINDTIRMIDAYSHLETFYTDEKEKKFAALNDSDESDDDEASSCHDQLKGNVKKSLKLDETDEFLMNLFFDNKKMLKKLAENPKYENEKLIKLRNTILEQFTRSEESSRGIIFTKTRQSTYALSQWIMENEKFAEVGVKAHHLIGAGHSSEVKPMTQTEQKEVISKFRTGEINLLIATTVAEEGLDIKECNIVIRYGLVTNEIAMVQARGRARADESTYVLVTSSGSGVTEREIVNDFREKMMYKAINRVQNMKPEEYAHKILELQVQSILEKKMKVKRSIARQYNSDPSLITLLCKNCSTLVCSGENIHVIEKMHHVNMTPEFKGLYIVRENKALQMKFADYQTNGEIICKCGQAWGTMMVHKGLDLPCLKIRNFVVNFKNNSSKKQYKKWVELPIRFPDLDCSEYCLYSDED", "length": 1027 }, "evidence": [ { "id": "SGD:S000001441", "url": "https://alliancegenome.org/gene/SGD:S000001441#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O95786-1", "protein_name": "Antiviral innate immune response receptor RIG-I", "gene_name": "RIGI", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTTEQRRSLQAFQDYIRKTLDPTYILSYMAPWFREEEVQYIQAEKNNKGPMEAATLFLKFLLELQEEGWFRGFLDALDHAGYSGLYEAIESWDFKKIEKLEEYRLLLKRLQPEFKTRIIPTDIISDLSECLINQECEEILQICSTKGMMAGAEKLVECLLRSDKENWPKTLKLALEKERNKFSELWIVEKGIKDVETEDLEDKMETSDIQIFYQEDPECQNLSENSCPPSEVSDTNLYSPFKPRNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQGQKGKVVFFANQIPVYEQQKSVFSKYFERHGYRVTGISGATAENVPVEQIVENNDIIILTPQILVNNLKKGTIPSLSIFTLMIFDECHNTSKQHPYNMIMFNYLDQKLGGSSGPLPQVIGLTASVGVGDAKNTDEALDYICKLCASLDASVIATVKHNLEELEQVVYKPQKFFRKVESRISDKFKYIIAQLMRDTESLAKRICKDLENLSQIQNREFGTQKYEQWIVTVQKACMVFQMPDKDEESRICKALFLYTSHLRKYNDALIISEHARMKDALDYLKDFFSNVRAAGFDEIEQDLTQRFEEKLQELESVSRDPSNENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALKNWIEGNPKLSFLKPGILTGRGKTNQNTGMTLPAQKCILDAFKASGDHNILIATSVADEGIDIAQCNLVILYEYVGNVIKMIQTRGRGRARGSKCFLLTSNAGVIEKEQINMYKEKMMNDSILRLQTWDEAVFREKILHIQTHEKFIRDSQEKPKPVPDKENKKLLCRKCKALACYTADVRVIEECHYTVLGDAFKECFVSRPHPKPKQFSSFEKRAKIFCARQNCSHDWGIHVKYKTFEIPVIKIESFVVEDIATGVQTLYSKWKDFHFEKIPFDPAEMSK", "length": 925 }, "evidence": [ { "id": "SGD:S000001441", "url": "https://alliancegenome.org/gene/SGD:S000001441#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P40562-1", "protein_name": "ATP-dependent DNA helicase MPH1", "gene_name": "MPH1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MASADDYFSDFEDDELDKLYEKAINKSVKETITRRAVPVQKDLHDNVLPGQKTVYEEIQRDVSFGPTHHELDYDALSFYVYPTNYEVRDYQYTIVHKSLFQNTLCAIPTGMGKTFIASTVMLNYFRWTKKAKIIFTAPTRPLVAQQIKACLGITGIPSDQTAILLDKSRKNREEIWANKRVFFATPQVVENDLKRGVLDPKDIVCLVIDEAHRATGSSAYTNVVKFIDRFNSSYRLLALTATPASDLEGVQEVVNNLDISKIEIRTEESMDIVKYMKKRKKEKIEVPLLLEIEDIIEQLGMAVKPVLQQAIELGIYEECDPSQINAFKAMQQSQKIIANPTIPEGIKWRNFFILQLLNNVGQMLKRLKIYGIRTFFNYFQNKCTEFTTKYNLKKSTNKIAAEFYYHPILKNIKNQCENYLSDPKFVGHGKLQCVRDELMDFFQKRGSDSRVIIFTELRESALEIVKFIDSVADDQIRPHIFIGQARAKEGFDEVKYTRKHAPKGRKKVERLHRQEQEKFLEAERTKRAANDKLERSARRTGSSEEAQISGMNQKMQKEVIHNFKKGEYNVLVCTSIGEEGLDIGEVDLIICYDTTSSPIKNIQRMGRTGRKRDGKIVLLFSSNESYKFERAMEDYSTLQALISKQCIDYKKSDRIIPEDIIPECHETLITINDENEIINEMEDVDEVIRYATQCMMGKKVKPKKAITKKKRVQENKKPKKFFMPDNVETSIVSASTLINKFLVNESGGKQLVTSNENPSKKRKIFKALDNLENDSTEEASSSLETEDEEVSDDNNVFIAEGQNGCQKDLETAIIRTGESLTTLKPLHNFERPNMALFVNDCGLPTKIEKNVKDIRGNQHNLEKEKSCTVDKNNMVLSLDDWNFFRNRYIPEGVSFDVEPNFVQYTKGVKVPHCHKVSKIITLFNDESNDNKKRTIDMNYTKCLARGMLRDEKKFVKVNDKSQVDNNSVNHDSSQSFTLSNAELDDILGSDSDF", "length": 993 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-090929-1", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-090929-1#orthology", "database": "AGR" }, { "id": "RGD:1307897", "url": "https://alliancegenome.org/gene/RGD:1307897#orthology", "database": "AGR" }, { "id": "MGI:2442306", "url": "https://alliancegenome.org/gene/MGI:2442306#orthology", "database": "AGR" }, { "id": "SGD:S000001441", "url": "https://alliancegenome.org/gene/SGD:S000001441#orthology", "database": "AGR" }, { "id": "HGNC:23168", "url": "https://alliancegenome.org/gene/HGNC:23168#orthology", "database": "AGR" }, { "id": "FB:FBgn0038889", "url": "https://alliancegenome.org/gene/FB:FBgn0038889#orthology", "database": "AGR" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q6Q899-1", "protein_name": "Antiviral innate immune response receptor RIG-I", "gene_name": "Rigi", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTAEQRQNLQAFRDYIKKILDPTYILSYMSSWLEDEEVQYIQAEKNNKGPMEAASLFLQYLLKLQSEGWFQAFLDALYHAGYCGLCEAIESWDFQKIEKLEEHRLLLRRLEPEFKATVDPNDILSELSECLINQECEEIRQIRDTKGRMAGAEKMAECLIRSDKENWPKVLQLALEKDNSKFSELWIVDKGFKRAESKADEDDGAEASSIQIFIQEEPECQNLSQNPGPPSEASSNNLHSPLKPRNYQLELALPAKKGKNTIICAPTGCGKTFVSLLICEHHLKKFPCGQKGKVVFFANQIPVYEQQATVFSRYFERLGYNIASISGATSDSVSVQHIIEDNDIIILTPQILVNNLNNGAIPSLSVFTLMIFDECHNTSKNHPYNQIMFRYLDHKLGESRDPLPQVVGLTASVGVGDAKTAEEAMQHICKLCAALDASVIATVRDNVAELEQVVYKPQKISRKVASRTSNTFKCIISQLMKETEKLAKDVSEELGKLFQIQNREFGTQKYEQWIVGVHKACSVFQMADKEEESRVCKALFLYTSHLRKYNDALIISEDAQMTDALNYLKAFFHDVREAAFDETERELTRRFEEKLEELEKVSRDPSNENPKLRDLYLVLQEEYHLKPETKTILFVKTRALVDALKKWIEENPALSFLKPGILTGRGRTNRATGMTLPAQKCVLEAFRASGDNNILIATSVADEGIDIAECNLVILYEYVGNVIKMIQTRGRGRARDSKCFLLTSSADVIEKEKANMIKEKIMNESILRLQTWDEMKFGKTVHRIQVNEKLLRDSQHKPQPVPDKENKKLLCGKCKNFACYTADIRVVETSHYTVLGDAFKERFVCKPHPKPKIYDNFEKKAKIFCAKQNCSHDWGIFVRYKTFEIPVIKIESFVVEDIVSGVQNRHSKWKDFHFERIQFDPAEMSV", "length": 926 }, "evidence": [ { "id": "SGD:S000001441", "url": "https://alliancegenome.org/gene/SGD:S000001441#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8BGE5-1", "protein_name": "Fanconi anemia group M protein homolog", "gene_name": "Fancm", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSGRQRTLFQTWGPSLVRGSGDSGCGQPRSPAMAEALPEEDDEVLLVAAYEAERQLDPGDGGFCAAAGALWIYPTNCPVRDYQLDISRSALFCNTLVCLPTGLGKTFIAAVVMYNFYRWFPSGKVVFMAPTKPLVTQQMEACFHVMGIPQSHMAEMTGSTQAVNRKEIWSSRRVLFLTPQVMVNDLTRGAVPATHVKCLVVDEAHKALGNYAYCQVVRELVKYTTHFRILALSATPGSDIKAVQQVITNLLIGKIELRSEESPDILPYSHERRVEKLVVPLGEELGAIQKTYIQILETFASSLIHRNVLMKRDIPNLTKYQIILARDQFRKNPSPNIVGIQQGIIEGEFALCISLYHGYELLQQMGMRSLYFFLSGIMDGTKGMTRARNELSRNEDFMKLYTHLQSAFAPASTSDASAFQRGNKEKKFVYSHPKLKKLEEVILEHFKSWNAKATTEKKCHESRVMIFSSFRDSVEEIAEMLLQHRPVIRVMTFVGHASGKNTKGFTQKEQLQVVRQFRDGGYNTLVSTCVGEEGLDIGEVDLIICFDAQKSPIRLIQRMGRTGRKRQGRIVVILAEGREERTYNQSQSNKKNIYKAISGNRQVLRLYQGSPRMVPDKINPELHKMYITHGVYEPEKARSVQRRPFSSRGGIKASKSNKDGLLSEEEFNLWSRLYRLGDSDQVKGVALPQSHFPSLQEDRVIQDPTTRIHQLSLSEWSLWQDRPLPTHQVDHSDRCHHFISIMKMIEGMRHEEGECSYELKIRPFLQMEDVCSKYHAPRNGYNNVASVASSAHQKSSFRPSVDAGGSLTVIESEEEHADTVKQRDSKWTKITSLREKPCRAGRKGQTCEHSEGEGEDGDAGSSDADGQSPAEADSQVDPPSGERMADVGGISILGAVTEEDNHPGTLQMECQVTNKSCARYSLDSGYSSFSDEKSVSSNLFLPLEEELFTDRAAEQFYNCRPMTEDVLANVERFLSRSPPSLSGLSDLVYDVTQGCEFDNASCSPYPEHEHSPRPVSPASHSAGNSQQNLESNSAKRISHPTEKYCLPGTTHNKVSDRPSFCESDSEGHNIKYQNSGSNSCAQIQADLENNFVDKNSHDDSEPPVLFTDEDESLLLFEDDFKNIEDGPEELNGASLPPFNSISQPLRVSGKTLTSEMPPVSHFLISDELLLDDDSEPEDQIVCGAKSWKCQEGVEDGQEELRTDGQTFDCSVDLFSVTFDLGFRCSSGSDDEMLAGASDRTRTLGAADVSGRHSDKEIKDAGGASGPLGRAISPIPTETAQWSPWAQNKEYASFHVASSSPVKQRVRSTPLSKSHASSKTGAHMLKTLDSTKEKAGGQGFKMALNPRLGHLGFSVEETKSSDQVFVHQSPRRTEVEHLTSESEDDVFLRKTKKPKRNVLKSPEDQKNNEVDSPIHAVKKPRVLRSELASSDDESENFGRTCPRLEHFKGRNRNIRKGSAAQKNRSQVKTMARRFLDDEAEVSGEDVDCVSADEEDESENEQDSSLLDFVNDRTQLSQAINDSEMRAIYMKSVRSPLMSTKYRMVREKRPNMNIFSQIPEQDENYLEDSFCVDEEESCKSQSSEEEISVDFNLTKDSFTDEDIRYKTRYAVKIKQMNKKQNYTRPRKKLSRIILPDDDSSEEENIPKDREHSVAGGHAAAEHTQQGQLWASGPSGSSVPPQVLSDPSWNQSSRQRLQVQPSITDAVPRTLNVKAQSHNKIKSASPPCTGVESRKEYGNHPVQLKADSQEHSDTSAAPCSTSLLHVAEGHTAPRHLQEGNRACILVDSREITTGLEVISSLRTVHGLQVEICPLNGCDYIVSSRMVVVRRSQSEMLSNTSKNKFIEQMQRLQSMFQRICVIVEKDREKAGDTSKKFRRTKCYDSLLTALVGAGIRILFSSGQEETADLLKELSLVEQRKNAGIHIPAVLNTSKLEALPFYLSIPGISYITALNMCHQFSSVKKMANSSPEEISTCAQVNHQKAEEIYKYIHYIFDMQMLPNDLNQERQKPDTCLTLGVAMKELS", "length": 2021 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-090929-1", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-090929-1#orthology", "database": "AGR" }, { "id": "RGD:1307897", "url": "https://alliancegenome.org/gene/RGD:1307897#orthology", "database": "AGR" }, { "id": "MGI:2442306", "url": "https://alliancegenome.org/gene/MGI:2442306#orthology", "database": "AGR" }, { "id": "SGD:S000001441", "url": "https://alliancegenome.org/gene/SGD:S000001441#orthology", "database": "AGR" }, { "id": "HGNC:23168", "url": "https://alliancegenome.org/gene/HGNC:23168#orthology", "database": "AGR" }, { "id": "FB:FBgn0038889", "url": "https://alliancegenome.org/gene/FB:FBgn0038889#orthology", "database": "AGR" }, { "id": "A0A0G2K7F0", "url": "https://omabrowser.org/oma/group/A0A0G2K7F0/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IYD8-1", "protein_name": "Fanconi anemia group M protein", "gene_name": "FANCM", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSGRQRTLFQTWGSSISRSSGTPGCSSGTERPQSPGSSKAPLPAAAEAQLESDDDVLLVAAYEAERQLCLENGGFCTSAGALWIYPTNCPVRDYQLHISRAALFCNTLVCLPTGLGKTFIAAVVMYNFYRWFPSGKVVFMAPTKPLVTQQIEACYQVMGIPQSHMAEMTGSTQASTRKEIWCSKRVLFLTPQVMVNDLSRGACPAAEIKCLVIDEAHKALGNYAYCQVVRELVKYTNHFRILALSATPGSDIKAVQQVITNLLIGQIELRSEDSPDILTYSHERKVEKLIVPLGEELAAIQKTYIQILESFARSLIQRNVLMRRDIPNLTKYQIILARDQFRKNPSPNIVGIQQGIIEGEFAICISLYHGYELLQQMGMRSLYFFLCGIMDGTKGMTRSKNELGRNEDFMKLYNHLECMFARTRSTSANGISAIQQGDKNKKFVYSHPKLKKLEEVVIEHFKSWNAENTTEKKRDETRVMIFSSFRDSVQEIAEMLSQHQPIIRVMTFVGHASGKSTKGFTQKEQLEVVKQFRDGGYNTLVSTCVGEEGLDIGEVDLIICFDSQKSPIRLVQRMGRTGRKRQGRIVIILSEGREERIYNQSQSNKRSIYKAISSNRQVLHFYQRSPRMVPDGINPKLHKMFITHGVYEPEKPSRNLQRKSSIFSYRDGMRQSSLKKDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQVQFSSLQNEENKPAQESTTGIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIEGMRHEEGECSYELEVESYLQMEDVTSTFIAPRNESNNLASDTFITHKKSSFIKNINQGSSSSVIESDEECAEIVKQTHIKPTKIVSLKKKVSKEIKKDQLKKENNHGIIDSVDNDRNSTVENIFQEDLPNDKRTSDTDEIAATCTINENVIKEPCVLLTECQFTNKSTSSLAGNVLDSGYNSFNDEKSVSSNLFLPFEEELYIVRTDDQFYNCHSLTKEVLANVERFLSYSPPPLSGLSDLEYEIAKGTALENLLFLPCAEHLRSDKCTCLLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPNDNISDEPSLCDCDVHKHNQNENLVPNNRVQIHRSPAQNLVGENNHDVDNSDLPVLSTDQDESLLLFEDVNTEFDDVSLSPLNSKSESLPVSDKTAISETPLVSQFLISDELLLDNNSELQDQITRDANSFKSRDQRGVQEEKVKNHEDIFDCSRDLFSVTFDLGFCSPDSDDEILEHTSDSNRPLDDLYGRYLEIKEISDANYVSNQALIPRDHSKNFTSGTVIIPSNEDMQNPNYVHLPLSAAKNEELLSPGYSQFSLPVQKKVMSTPLSKSNTLNSFSKIRKEILKTPDSSKEKVNLQRFKEALNSTFDYSEFSLEKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEIFRRKVKRAKGNVLNSPEDQKNSEVDSPLHAVKKRRFPINRSELSSSDESENFPKPCSQLEDFKVCNGNARRGIKVPKRQSHLKHVARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDFLNDETQLSQAINDSEMRAIYMKSLRSPMMNNKYKMIHKTHKNINIFSQIPEQDETYLEDSFCVDEEESCKGQSSEEEVCVDFNLITDDCFANSKKYKTRRAVMLKEMMEQNCAHSKKKLSRIILPDDSSEEENNVNDKRESNIAVNPSTVKKNKQQDHCLNSVPSGSSAQSKVRSTPRVNPLAKQSKQTSLNLKDTISEVSDFKPQNHNEVQSTTPPFTTVDSQKDCRKFPVPQKDGSALEDSSTSGASCSKSRPHLAGTHTSLRLPQEGKGTCILVGGHEITSGLEVISSLRAIHGLQVEVCPLNGCDYIVSNRMVVERRSQSEMLNSVNKNKFIEQIQHLQSMFERICVIVEKDREKTGDTSRMFRRTKSYDSLLTTLIGAGIRILFSSCQEETADLLKELSLVEQRKNVGIHVPTVVNSNKSEALQFYLSIPNISYITALNMCHQFSSVKRMANSSLQEISMYAQVTHQKAEEIYRYIHYVFDIQMLPNDLNQDRLKSDI", "length": 2048 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-090929-1", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-090929-1#orthology", "database": "AGR" }, { "id": "RGD:1307897", "url": "https://alliancegenome.org/gene/RGD:1307897#orthology", "database": "AGR" }, { "id": "MGI:2442306", "url": "https://alliancegenome.org/gene/MGI:2442306#orthology", "database": "AGR" }, { "id": "SGD:S000001441", "url": "https://alliancegenome.org/gene/SGD:S000001441#orthology", "database": "AGR" }, { "id": "HGNC:23168", "url": "https://alliancegenome.org/gene/HGNC:23168#orthology", "database": "AGR" }, { "id": "FB:FBgn0038889", "url": "https://alliancegenome.org/gene/FB:FBgn0038889#orthology", "database": "AGR" }, { "id": "A0A0G2K7F0", "url": "https://omabrowser.org/oma/group/A0A0G2K7F0/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8R5F7-1", "protein_name": "Interferon-induced helicase C domain-containing protein 1", "gene_name": "Ifih1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSIVCSAEDSFRNLILFFRPRLKMYIQVEPVLDHLIFLSAETKEQILKKINTCGNTSAAELLLSTLEQGQWPLGWTQMFVEALEHSGNPLAARYVKPTLTDLPSPSSETAHDECLHLLTLLQPTLVDKLLINDVLDTCFEKGLLTVEDRNRISAAGNSGNESGVRELLRRIVQKENWFSTFLDVLRQTGNDALFQELTGGGCPEDNTDLANSSHRDGPAANECLLPAVDESSLETEAWNVDDILPEASCTDSSVTTESDTSLAEGSVSCFDESLGHNSNMGRDSGTMGSDSDESVIQTKRVSPEPELQLRPYQMEVAQPALDGKNIIICLPTGSGKTRVAVYITKDHLDKKKQASESGKVIVLVNKVMLAEQLFRKEFNPYLKKWYRIIGLSGDTQLKISFPEVVKSYDVIISTAQILENSLLNLESGDDDGVQLSDFSLIIIDECHHTNKEAVYNNIMRRYLKQKLRNNDLKKQNKPAIPLPQILGLTASPGVGAAKKQSEAEKHILNICANLDAFTIKTVKENLGQLKHQIKEPCKKFVIADDTRENPFKEKLLEIMASIQTYCQKSPMSDFGTQHYEQWAIQMEKKAAKDGNRKDRVCAEHLRKYNEALQINDTIRMIDAYSHLETFYTDEKEKKFAVLNDSDKSDDEASSCNDQLKGDVKKSLKLDETDEFLMNLFFDNKKMLKKLAENPKYENEKLIKLRNTILEQFTRSEESSRGIIFTKTRQSTYALSQWIMENAKFAEVGVKAHHLIGAGHSSEVKPMTQTEQKEVISKFRTGEINLLIATTVAEEGLDIKECNIVIRYGLVTNEIAMVQARGRARADESTYVLVTSSGSGVTEREIVNDFREKMMYKAINRVQNMKPEEYAHKILELQVQSILEKKMKVKRSIAKQYNDNPSLITLLCKNCSMLVCSGENIHVIEKMHHVNMTPEFKGLYIVRENKALQKKFADYQTNGEIICKCGQAWGTMMVHKGLDLPCLKIRNFVVNFKNNSPKKQYKKWVELPIRFPDLDYSEYCLYSDED", "length": 1025 }, "evidence": [ { "id": "SGD:S000001441", "url": "https://alliancegenome.org/gene/SGD:S000001441#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96C10-1", "protein_name": "ATP-dependent RNA helicase DHX58", "gene_name": "DHX58", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MELRSYQWEVIMPALEGKNIIIWLPTGAGKTRAAAYVAKRHLETVDGAKVVVLVNRVHLVTQHGEEFRRMLDGRWTVTTLSGDMGPRAGFGHLARCHDLLICTAELLQMALTSPEEEEHVELTVFSLIVVDECHHTHKDTVYNVIMSQYLELKLQRAQPLPQVLGLTASPGTGGASKLDGAINHVLQLCANLDTWCIMSPQNCCPQLQEHSQQPCKQYNLCHRRSQDPFGDLLKKLMDQIHDHLEMPELSRKFGTQMYEQQVVKLSEAAALAGLQEQRVYALHLRRYNDALLIHDTVRAVDALAALQDFYHREHVTKTQILCAERRLLALFDDRKNELAHLATHGPENPKLEMLEKILQRQFSSSNSPRGIIFTRTRQSAHSLLLWLQQQQGLQTVDIRAQLLIGAGNSSQSTHMTQRDQQEVIQKFQDGTLNLLVATSVAEEGLDIPHCNVVVRYGLLTNEISMVQARGRARADQSVYAFVATEGSRELKRELINEALETLMEQAVAAVQKMDQAEYQAKIRDLQQAALTKRAAQAAQRENQRQQFPVEHVQLLCINCMVAVGHGSDLRKVEGTHHVNVNPNFSNYYNVSRDPVVINKVFKDWKPGGVISCRNCGEVWGLQMIYKSVKLPVLKVRSMLLETPQGRIQAKKWSRVPFSVPDFDFLQHCAENLSDLSLD", "length": 678 }, "evidence": [ { "id": "SGD:S000001441", "url": "https://alliancegenome.org/gene/SGD:S000001441#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q99J87-1", "protein_name": "ATP-dependent RNA helicase DHX58", "gene_name": "Dhx58", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MELRPYQWEVILPALEGKNIIIWLPTGAGKTRAAAFVAKRHLETVDRGKVVVLVNRVHLVSQHAEEFRRMLDKHWTVTTLSGDMGSRAGFGLMARSHDLLICTAELLQLALNSSEEDEHVELREFSLIVVDECHHTHKDTVYNTILSRYLEQKLKKAEPLPQVLGLTASPGTGGATKLQGAIDHILQLCANLDTCHIMSPKNCYSQLLMHNPKPCKQYDLCQRRAQDPFGDLIKKLMNQIHQQLEMPDLKQQFGTQMYEQQVVQLCKDAAEAGLQEQRVYALHLRRYNDALFIHDTVRARDALDMLQDFYDRERTTKTQMVRAESWLLKLFDDHKNVLGQLAARGPENPKLEMLERILLKQFGSPGHTRGIIFTRTRQTASSLLLWLRQQPCLQTVGIKPQMLIGAGNTSQSTHMTQKDQQEVIQEFRDGILSLLVATSVAEEGLDIAQCNVVVRYGLLTNEISMVQARGRARAGQSVYSFLATEGSREMKRELTNEALEVLMEKAVAAVQKMDPDEFKAKIRDLQQASLVKRAARAAHREIQQGQFLPEHVQLLCINCMVAVGYGSDLRKVEGTHHVNVNPNFSVYYTTSQNPVVINKVFKDWRPGGTIRCSNCGEVWGFQMIYKSVTLPVLKIGSILLETPRGKIQAKKWSRVPFSIPVFDILQDCTQSLSELSLD", "length": 678 }, "evidence": [ { "id": "SGD:S000001441", "url": "https://alliancegenome.org/gene/SGD:S000001441#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BYX4-1", "protein_name": "Interferon-induced helicase C domain-containing protein 1", "gene_name": "IFIH1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSNGYSTDENFRYLISCFRARVKMYIQVEPVLDYLTFLPAEVKEQIQRTVATSGNMQAVELLLSTLEKGVWHLGWTREFVEALRRTGSPLAARYMNPELTDLPSPSFENAHDEYLQLLNLLQPTLVDKLLVRDVLDKCMEEELLTIEDRNRIAAAENNGNESGVRELLKRIVQKENWFSAFLNVLRQTGNNELVQELTGSDCSESNAEIENLSQVDGPQVEEQLLSTTVQPNLEKEVWGMENNSSESSFADSSVVSESDTSLAEGSVSCLDESLGHNSNMGSDSGTMGSDSDEENVAARASPEPELQLRPYQMEVAQPALEGKNIIICLPTGSGKTRVAVYIAKDHLDKKKKASEPGKVIVLVNKVLLVEQLFRKEFQPFLKKWYRVIGLSGDTQLKISFPEVVKSCDIIISTAQILENSLLNLENGEDAGVQLSDFSLIIIDECHHTNKEAVYNNIMRHYLMQKLKNNRLKKENKPVIPLPQILGLTASPGVGGATKQAKAEEHILKLCANLDAFTIKTVKENLDQLKNQIQEPCKKFAIADATREDPFKEKLLEIMTRIQTYCQMSPMSDFGTQPYEQWAIQMEKKAAKEGNRKERVCAEHLRKYNEALQINDTIRMIDAYTHLETFYNEEKDKKFAVIEDDSDEGGDDEYCDGDEDEDDLKKPLKLDETDRFLMTLFFENNKMLKRLAENPEYENEKLTKLRNTIMEQYTRTEESARGIIFTKTRQSAYALSQWITENEKFAEVGVKAHHLIGAGHSSEFKPMTQNEQKEVISKFRTGKINLLIATTVAEEGLDIKECNIVIRYGLVTNEIAMVQARGRARADESTYVLVAHSGSGVIEHETVNDFREKMMYKAIHCVQNMKPEEYAHKILELQMQSIMEKKMKTKRNIAKHYKNNPSLITFLCKNCSVLACSGEDIHVIEKMHHVNMTPEFKELYIVRENKALQKKCADYQINGEIICKCGQAWGTMMVHKGLDLPCLKIRNFVVVFKNNSTKKQYKKWVELPITFPNLDYSECCLFSDED", "length": 1025 }, "evidence": [ { "id": "SGD:S000001441", "url": "https://alliancegenome.org/gene/SGD:S000001441#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VDA0-1", "protein_name": "DEAD-box ATP-dependent DNA helicase Fancm", "gene_name": "Fancm", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MDVNWMDDDEDLVAALAMHEEQKSEDADGTRWEHCDEACDGFDMATGHNWIYPNNLPLRSYQQTIVQSALFKNTLVVLPTGLGKTFIAAVVMYNFYRWYPKGKIVFMAPTRPLVSQQIHASQKIMPFPSEDTVQLTGQLPRPKRAELWASKRVFFATPQVVHSDMLEADGECSFPFGSIKLIVVDEAHRAKGRYAYTQVADCLMARNRYFRMLALSATPGRTMEDVAAVCRNLYISNLQVRWDTSIDVQPYIHRRTIRTIVVSLKERIKEPRERLLQIIEPYLRQLMEAEIFKGNKGTVSRNSLLFEQKSFVERSAQGQRHPDHNIIMGNFAMCISMYHSLDLMERHGLRVFVNNFDADDDGREKFVLARDGNLRNLVEQVRQELGANPLDYTTHAMTNGEVPPLPSDLDFGHAKYEKLRQVLVQHFQANPDSRAIVFCEYRESVMLIHRLLLQHRPVLRPRCFVGQGSTVGASYALTQKQQLQIMTDFRSGTSNVLVATSIGEEGLDVGEVEMIVCFDICSTNPTRFIQRIGRTGRKKNGEVVMLVTEGREQQVLKDVLANKDQINKKLLNSSVVKLSLYEQNPRMVPSKFQPKCEEKHMEPVAEEKPKPKSAAKTKESRKRKQPVAQTGSLRKYFKESPPTESQQGILQGIKPYQMSEASQQLVKQQVLRRSVTLKNFFGESQASSTLTSSQEDVQRLRKLTRLLQSSKPFVSDSKDLMSHLQDDHLPRQIKLYLLKSNPEFLRETHLKMQVQSELNIADDRLNSRQRRTKNNYQLLLDICDGMDQMNELLQGDNSGAEISFRDELNPIYNQSPKKFDTICEQIFDGLNEHGLNSNNFELKQDLLEKLELRNLETTVNEQLGGIEASWSEEEWDQQEEDVKFESMYLSQQLNLPDANVVPHSSTPLRVKPLSKLMFKTLQGDIEEEYHSGMEASELGDNLGRLNSLMNASESKIKATERIAPIPVVDSTIETNHFPAVEESQRSTPISIADSSGESNHCAVNKNSEIYPMSIDETKVEVKSSLNLKMHAESIVEDLDIDLDDFLEPMDKELELASQTKGKSQENIVDHQMEKLEKNCEQKETAHNNDLDLTDEDLKEFLEPMVEEVELMSQKKANDFKDFLEPMPEELELMSQQKKNILLPSTETIKNSENKNSHEDGSRTVSPDIFGSDSMSPLKPQGKSLAAKLAAKAAAKVLPCPPPNSVGLNSPENRKRTNPSIQEKSPSIFDLYLNRMRGRGRLAKAAENLHRITSTNPTISVPKDEEDSPIARRPSKRKIVISSDEEEEQKPQIAETQVDCESDDYERILDTQMPDPRKTPTRPRHKRSKFNSFILDEAEKSGSDHEEEGETTIGTYLKDSMIVSSDDEDHNDTNTHAIYLRALKSPIQRPGAFKMPPPRVFRDESHIFSQPVEDDSSQYMQCSFIVDDESSTIERGHDVSECPLEKAERILKERRKQRRLGKVPSAPVNKRRRLQTISTSSDEDDVVLID", "length": 1489 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-090929-1", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-090929-1#orthology", "database": "AGR" }, { "id": "RGD:1307897", "url": "https://alliancegenome.org/gene/RGD:1307897#orthology", "database": "AGR" }, { "id": "MGI:2442306", "url": "https://alliancegenome.org/gene/MGI:2442306#orthology", "database": "AGR" }, { "id": "SGD:S000001441", "url": "https://alliancegenome.org/gene/SGD:S000001441#orthology", "database": "AGR" }, { "id": "HGNC:23168", "url": "https://alliancegenome.org/gene/HGNC:23168#orthology", "database": "AGR" }, { "id": "FB:FBgn0038889", "url": "https://alliancegenome.org/gene/FB:FBgn0038889#orthology", "database": "AGR" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "resolution of meiotic recombination intermediates", "id": "GO:0000712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000712", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7F0", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K7F0" } ], "pmid": "" }, { "name": "interstrand cross-link repair", "id": "GO:0036297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036297", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7F0", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K7F0" } ], "pmid": "" }, { "name": "replication fork processing", "id": "GO:0031297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031297", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7F0", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K7F0" } ], "pmid": "" }, { "name": "positive regulation of protein monoubiquitination", "id": "GO:1902527", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902527", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7F0", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K7F0" } ], "pmid": "" }, { "name": "double-strand break repair via synthesis-dependent strand annealing", "id": "GO:0045003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045003", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7F0", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K7F0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "3'-5' DNA helicase activity", "id": "GO:0043138", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043138", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7F0", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K7F0" } ], "pmid": "" }, { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7F0", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K7F0" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7F0", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K7F0" } ], "pmid": "" }, { "name": "nuclease activity", "id": "GO:0004518", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004518", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7F0", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K7F0" } ], "pmid": "" }, { "name": "four-way junction DNA binding", "id": "GO:0000400", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000400", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7F0", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K7F0" } ], "pmid": "" }, { "name": "four-way junction helicase activity", "id": "GO:0009378", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009378", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7F0", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K7F0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "Fanconi anaemia nuclear complex", "id": "GO:0043240", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043240", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7F0", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K7F0" } ], "pmid": "" }, { "name": "FANCM-MHF complex", "id": "GO:0071821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071821", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7F0", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K7F0" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7F0", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K7F0" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K7F0", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K7F0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1527, "end_pos": 1529, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1598, "end_pos": 1600, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1627, "end_pos": 1629, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1694, "end_pos": 1696, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1723, "end_pos": 1725, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1967, "end_pos": 1969, "annotation": "n_glycosylation_sequon" }, { "start_pos": 316, "end_pos": 318, "annotation": "n_glycosylation_sequon" }, { "start_pos": 457, "end_pos": 459, "annotation": "n_glycosylation_sequon" }, { "start_pos": 588, "end_pos": 590, "annotation": "n_glycosylation_sequon" }, { "start_pos": 999, "end_pos": 1001, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "13065", "name": "", "equation": "ATP + H2O = ADP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D4A523-1", "Q3MHU3-1", "P60123-1", "Q793F9-1", "Q6P3V8-1", "F1LNJ2-1", "D4A2Z8-1", "E9PT29-1", "A0A8I5ZKX7-1", "G3V681-1", "G3V9M1-1", "A0A0G2K7X6-1", "A0A0G2K9N3-1", "F1M298-1", "A0A0G2K0E0-1", "Q5RKI1-1", "D4ADE8-1", "D3ZD73-1", "F1MAM8-1", "E9PTF0-1", "D4A031-1", "Q66HG7-1", "Q64060-1", "D4A7Q5-1", "M0R9C6-1", "P70486-1", "Q99PT0-1", "D3ZG52-1", "Q5U216-1", "Q62780-1", "Q641Y8-1", "Q5BJS0-1", "Q63413-1", "P06761-1", "Q6GX84-1", "Q5XI69-1", "Q9QUL6-1", "Q3B8Q2-1", "P46462-1", "Q68G38-1", "Q9QY16-1", "Q62724-1", "Q5EBA1-1", "Q3B8Q1-1", "Q9EQN5-1", "F1M5F3-1", "D3ZVK1-1", "F1M9L4-1", "F1MA70-1", "A0A8I5ZZZ0-1", "D3ZFP4-1", "A0A0G2K0H9-1", "D3ZBY5-1", "D3Z9Z9-1", "D3ZX56-1", "Q9WTT2-1", "Q8CG07-1", "P08289-1", "Q5XIR6-1", "B2GUX3-1", "D3ZHW0-1", "D3ZP96-1", "G3V8T5-1", "B1H269-1", "Q6VEU8-1", "Q5XI46-1", "A0A8I5ZKH1-1", "D3ZD46-1", "A0A096MJY0-1", "A0A096MJV7-1", "D3ZA12-1", "D4AAG9-1", "A0A0G2JTM6-1", "D4A321-1", "A0A8I6ABZ7-1", "E9PU01-1", "A0A8I5ZKV9-1", "D3ZD32-1", "P62738-1", "P63259-1", "P68035-1", "P68136-1", "P60711-1", "P63269-1", "P56536-1", "P54777-1", "Q6MG13-1", "D3ZSV6-1", "D3ZUC2-1", "A0A8I6GIY0-1", "D3ZD97-1", "A0A0G2K283-1", "D3ZAP7-1", "G3V6W5-1", "P63018-1", "P82995-1", "Q9JIX5-1", "D4A6Q6-1", "A0A8I6GIN4-1", "A6KAR2-1", "D4ADT5-1", "A6KSS8-1", "D4A2B7-1", "A0A8I6GF11-1", "D3ZH42-1", "A0A0G2K4S4-1", "F1LTR3-1", "F1LWY1-1", "P97687-1", "Q9JIL8-1", "Q925S8-1", "D4ACP5-1", "Q6AYJ1-1", "Q641Z7-1", "Q5EB68-1", "Q4G005-1", "A0A8I6AGW3-1", "Q5BKE0-1", "P34158-1", "Q7TT47-1", "M0RCB1-1", "D4A628-1", "Q5RJZ1-1", "Q3KRE0-1", "F1M3J4-1", "D3ZEG9-1", "G3V9T7-1", "A0A0G2K8J3-1", "A0A0G2K475-1", "P28480-1", "Q1HG60-1", "Q5XIM9-1", "B4F769-1", "Q68FQ0-1", "Q7TPB1-1", "Q8K1P7-1", "A0A8I6AKP6-1", "A0A0G2K7F0-1", "A1L1L6-1", "A0A8I6GH80-1", "D3ZZK7-1", "D4A5W5-1", "A0A0G2QC02-1", "P48721-1", "D4A474-1", "Q5U2U0-1", "Q6P502-1", "Q7TSA0-1", "Q66HD0-1", "A0A8I6GF73-1", "E9PT19-1", "F1LPQ2-1", "D3ZA68-1", "D4AAN8-1", "D4ADC2-1", "A0A8I5ZKZ9-1", "A0A8I6A2A6-1", "A0A0G2JZH9-1", "D3ZGJ0-1", "D3ZV87-1", "A0A8I5ZN47-1", "A0A8I5Y8G8-1", "D3ZYS7-1", "A0A8I6AUH3-1", "M0R9X1-1" ], "evidence": [ { "id": "13065", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13065" } ] }, { "id": "R-RNO-6785342", "name": "FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0G2K7F0-1", "D3ZAU3-1", "G3V6M7-1" ], "evidence": [ { "id": "R-RNO-6785342", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6785342" } ] }, { "id": "R-RNO-6785361", "name": "Monoubiquitination of FANCD2:FANCI", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0G2K7F0-1", "D3ZAU3-1", "G3V6M7-1" ], "evidence": [ { "id": "R-RNO-6785361", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6785361" } ] }, { "id": "R-RNO-6785607", "name": "FANCM binds FAAP24", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0G2K7F0-1" ], "evidence": [ { "id": "R-RNO-6785607", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6785607" } ] }, { "id": "R-RNO-6785732", "name": "DNA nucleases bind monoubiquitinated ID2 complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q569C3-1", "Q5PQP5-1", "A0A0G2K7F0-1", "D3ZAU3-1", "D3Z924-1", "Q4KLY6-1", "Q4KM32-1", "D3ZVU2-1" ], "evidence": [ { "id": "R-RNO-6785732", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6785732" } ] }, { "id": "R-RNO-6785986", "name": "DNA nucleases unhook the interstrand crosslink (ICL)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5PQP5-1", "A0A0G2K7F0-1", "D3ZAU3-1", "D3Z924-1", "Q4KLY6-1", "Q4KM32-1", "D3ZVU2-1" ], "evidence": [ { "id": "R-RNO-6785986", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6785986" } ] }, { "id": "R-RNO-6786155", "name": "POLN binds ICL-DNA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0G2K7F0-1", "D3ZAU3-1", "F1LWX6-1" ], "evidence": [ { "id": "R-RNO-6786155", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6786155" } ] }, { "id": "R-RNO-6786166", "name": "Translesion synthesis across unhooked ICL by POLN", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [ "R-ALL-5688114", "R-ALL-75165", "R-RNO-6786153" ], "enzyme_list": [ "A0A0G2K7F0-1", "D3ZAU3-1", "F1LWX6-1" ], "evidence": [ { "id": "R-RNO-6786166", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6786166" } ] }, { "id": "R-RNO-6786171", "name": "FANCD2 deubiquitination by USP1:WDR48", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q569C3-1", "A0A0G2K7F0-1", "D3ZAU3-1" ], "evidence": [ { "id": "R-RNO-6786171", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6786171" } ] }, { "id": "R-RNO-6788385", "name": "The complex of ATR and ATRIP is recruited to ICL-DNA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0G2K7F0-1", "D3Z822-1", "D3ZAU3-1", "G3V6M7-1" ], "evidence": [ { "id": "R-RNO-6788385", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6788385" } ] }, { "id": "R-RNO-6788392", "name": "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0G2K7F0-1", "D3Z822-1", "D3ZAU3-1", "G3V6M7-1" ], "evidence": [ { "id": "R-RNO-6788392", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6788392" } ] }, { "id": "R-RNO-9835411", "name": "FA core complex:HSP70s binds PKR", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P63018-1", "A0A0G2K7F0-1", "D3ZAU3-1", "Q63184-1" ], "evidence": [ { "id": "R-RNO-9835411", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9835411" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-5688114", "participant_name": "Distorted dsDNA [nucleoplasm]", "crossref": [ { "id": "61120", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-75165", "participant_name": "DNA double-strand break ends [nucleoplasm]", "crossref": [ { "id": "61120", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-RNO-6786153", "participant_name": "Haus3 [nucleoplasm]", "crossref": [ { "id": "1591723", "database": "RGD", "url": "" }, { "id": "F1LWX6", "database": "UniProt", "url": "" }, { "id": "ENSRNOP00000034638", "database": "ENSEMBL", "url": "" }, { "id": "7675413", "database": "RGD", "url": "" }, { "id": "ENSRNOT00000029784", "database": "ENSEMBL", "url": "" }, { "id": "ENSRNOG00000069005", "database": "ENSEMBL", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A096MJV7", "gene_name": "Chd9", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A096MJV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A096MJV7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A096MJV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A096MJV7" } ] } ] }, { "uniprot_ac": "A0A096MJY0", "gene_name": "Chd2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A096MJY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A096MJY0" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A096MJY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A096MJY0" } ] } ] }, { "uniprot_ac": "A0A0G2JTM6", "gene_name": "Dhx35", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A0G2JTM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JTM6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A0G2JTM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JTM6" } ] } ] }, { "uniprot_ac": "A0A0G2JZH9", "gene_name": "Dhx57", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A0G2JZH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JZH9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A0G2JZH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JZH9" } ] } ] }, { "uniprot_ac": "A0A0G2K0E0", "gene_name": "Ddx56", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A0G2K0E0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K0E0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A0G2K0E0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K0E0" } ] } ] }, { "uniprot_ac": "A0A0G2K0H9", "gene_name": "Ruvbl1-ps1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A0G2K0H9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K0H9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A0G2K0H9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K0H9" } ] } ] }, { "uniprot_ac": "A0A0G2K283", "gene_name": "Dhx8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A0G2K283", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K283" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A0G2K283", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K283" } ] } ] }, { "uniprot_ac": "A0A0G2K475", "gene_name": "Brip1", "activity": [ { "ec_number": "5.6.2.3", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A0G2K475", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K475" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "A0A0G2K475", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K475" } ] } ] }, { "uniprot_ac": "A0A0G2K4S4", "gene_name": "Ddx51", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "A0A0G2K4S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K4S4" } ] }, { "ec_number": "3.6.4.13", 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"3.5.2.6", "activity": "a beta-lactam + H2O = a substituted beta-amino acid.", "evidence": [ { "id": "D3Z924", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3Z924" } ] }, { "ec_number": "3.5.2.6", "activity": "", "evidence": [ { "id": "D3Z924", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3Z924" } ] } ] }, { "uniprot_ac": "D3Z9Z9", "gene_name": "Smarcad1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D3Z9Z9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3Z9Z9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3Z9Z9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3Z9Z9" } ] } ] }, { "uniprot_ac": "D3ZA12", "gene_name": "Chd6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D3ZA12", "database": "UniProtKB", "url": 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"https://www.uniprot.org/uniprotkb/D3ZAP7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZAP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZAP7" } ] } ] }, { "uniprot_ac": "D3ZAU3", "gene_name": "Fancl", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "D3ZAU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZAU3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "D3ZAU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZAU3" } ] } ] }, { "uniprot_ac": "D3ZBY5", "gene_name": "Ddx10", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D3ZBY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZBY5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZBY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZBY5" } ] } ] }, { "uniprot_ac": "D3ZD32", "gene_name": "Chd5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D3ZD32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZD32" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZD32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZD32" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "D3ZD32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZD32" } ] } ] }, { "uniprot_ac": "D3ZD46", "gene_name": "Dhx58", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D3ZD46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZD46" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZD46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZD46" } ] } ] }, { "uniprot_ac": "D3ZD73", "gene_name": "Ddx6", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D3ZD73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZD73" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZD73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZD73" } ] } ] }, { "uniprot_ac": "D3ZD97", "gene_name": "Dhx15", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D3ZD97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZD97" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZD97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZD97" } ] } ] }, { "uniprot_ac": "D3ZEG9", "gene_name": "Ercc2", "activity": [ { "ec_number": "5.6.2.3", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D3ZEG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZEG9" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "D3ZEG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZEG9" } ] } ] }, { "uniprot_ac": "D3ZFP4", "gene_name": "Mcm3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D3ZFP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZFP4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZFP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZFP4" } ] } ] }, { "uniprot_ac": "D3ZG52", "gene_name": "Dna2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "D3ZG52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZG52" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D3ZG52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZG52" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZG52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZG52" } ] } ] }, { "uniprot_ac": "D3ZGJ0", "gene_name": "Dhx32", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D3ZGJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZGJ0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZGJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZGJ0" } ] } ] }, { "uniprot_ac": "D3ZH42", "gene_name": "Mov10l1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D3ZH42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZH42" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZH42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZH42" } ] } ] }, { "uniprot_ac": "D3ZHW0", "gene_name": "Dhx29", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D3ZHW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZHW0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZHW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZHW0" } ] } ] }, { "uniprot_ac": "D3ZP96", "gene_name": "Mcm2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D3ZP96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZP96" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZP96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZP96" } ] } ] }, { "uniprot_ac": "D3ZSV6", "gene_name": "Dhx33", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D3ZSV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZSV6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZSV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZSV6" } ] } ] }, { "uniprot_ac": "D3ZUC2", "gene_name": "Mov10", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D3ZUC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZUC2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZUC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZUC2" } ] } ] }, { "uniprot_ac": "D3ZV87", "gene_name": "Rad54l2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D3ZV87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZV87" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZV87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZV87" } ] } ] }, { "uniprot_ac": "D3ZVK1", "gene_name": "Mcm8", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D3ZVK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZVK1" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZVK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZVK1" } ] } ] }, { "uniprot_ac": "D3ZVU2", "gene_name": "Fan1", "activity": [ { "ec_number": "3.1.4.1", "activity": "Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.", "evidence": [ { "id": "D3ZVU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZVU2" } ] }, { "ec_number": "3.1.4.1", "activity": "", "evidence": [ { "id": "D3ZVU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZVU2" } ] } ] }, { "uniprot_ac": "D3ZX56", "gene_name": "Ddx55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D3ZX56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZX56" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZX56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZX56" } ] } ] }, { "uniprot_ac": "D3ZYS7", "gene_name": "G3bp1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D3ZYS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZYS7" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D3ZYS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZYS7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZYS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZYS7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZYS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZYS7" } ] } ] }, { "uniprot_ac": "D3ZZK7", "gene_name": "Myo3a", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "D3ZZK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZZK7" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "D3ZZK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZZK7" } ] } ] }, { "uniprot_ac": "D4A031", "gene_name": "Ddx42", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D4A031", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A031" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D4A031", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A031" } ] } ] }, { "uniprot_ac": "D4A2B7", "gene_name": "Afg2b", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D4A2B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A2B7" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "D4A2B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A2B7" } ] } ] }, { "uniprot_ac": "D4A2Z8", "gene_name": "Dhx36", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D4A2Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A2Z8" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D4A2Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A2Z8" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D4A2Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A2Z8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D4A2Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A2Z8" } ] } ] }, { "uniprot_ac": "D4A321", "gene_name": "Dhx38", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D4A321", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A321" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D4A321", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A321" } ] } ] }, { "uniprot_ac": "D4A474", "gene_name": "Dqx1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D4A474", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A474" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D4A474", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A474" } ] } ] }, { "uniprot_ac": "D4A523", "gene_name": "Nlrp3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "D4A523", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A523" } ] } ] }, { "uniprot_ac": "D4A5W5", "gene_name": "Recql4", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D4A5W5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A5W5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "D4A5W5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A5W5" } ] } ] }, { "uniprot_ac": "D4A628", "gene_name": "Polq", "activity": [ { "ec_number": "2.7.7.7", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "D4A628", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A628" } ] }, { "ec_number": "2.7.7.49", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "D4A628", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A628" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D4A628", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A628" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D4A628", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A628" } ] }, { "ec_number": "2.7.7.49", "activity": "", "evidence": [ { "id": "D4A628", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A628" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "D4A628", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A628" } ] } ] }, { "uniprot_ac": "D4A6Q6", "gene_name": "Ino80", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "D4A6Q6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A6Q6" } ] } ] }, { "uniprot_ac": "D4A7Q5", "gene_name": "Ddx28", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D4A7Q5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A7Q5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D4A7Q5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4A7Q5" } ] } ] }, { "uniprot_ac": "D4AAG9", "gene_name": "Chd1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D4AAG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4AAG9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D4AAG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4AAG9" } ] } ] }, { "uniprot_ac": "D4AAN8", "gene_name": "Helb", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D4AAN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4AAN8" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D4AAN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4AAN8" } ] } ] }, { "uniprot_ac": "D4ACP5", "gene_name": "Recql5", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D4ACP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4ACP5" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "D4ACP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4ACP5" } ] } ] }, { "uniprot_ac": "D4ADC2", "gene_name": "Helz2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D4ADC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4ADC2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D4ADC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4ADC2" } ] }, { "ec_number": "3.1.13.1", "activity": "Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.", "evidence": [ { "id": "D4ADC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4ADC2" } ] }, { "ec_number": "3.1.13.1", "activity": "", "evidence": [ { "id": "D4ADC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4ADC2" } ] } ] }, { "uniprot_ac": "D4ADE8", "gene_name": "Ddx3x", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D4ADE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4ADE8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D4ADE8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4ADE8" } ] } ] }, { "uniprot_ac": "D4ADT5", "gene_name": "Rig1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "D4ADT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4ADT5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D4ADT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4ADT5" } ] } ] }, { "uniprot_ac": "E9PT19", "gene_name": "Helq", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E9PT19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E9PT19" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E9PT19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E9PT19" } ] } ] }, { "uniprot_ac": "E9PT29", "gene_name": "Ddx17", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E9PT29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E9PT29" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E9PT29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E9PT29" } ] } ] }, { "uniprot_ac": "E9PTF0", "gene_name": "Ddx49", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E9PTF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E9PTF0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "E9PTF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E9PTF0" } ] } ] }, { "uniprot_ac": "E9PU01", "gene_name": "Chd4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "E9PU01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E9PU01" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E9PU01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E9PU01" } ] } ] }, { "uniprot_ac": "F1LNJ2", "gene_name": "Snrnp200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1LNJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1LNJ2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1LNJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1LNJ2" } ] } ] }, { "uniprot_ac": "F1LPQ2", "gene_name": "Ascc3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1LPQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1LPQ2" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1LPQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1LPQ2" } ] }, { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1LPQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1LPQ2" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1LPQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1LPQ2" } ] } ] }, { "uniprot_ac": "F1LTR3", "gene_name": "Tdrd12", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1LTR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1LTR3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1LTR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1LTR3" } ] } ] }, { "uniprot_ac": "F1LWX6", "gene_name": "Haus3", "activity": [ { "ec_number": "2.7.7.7", "activity": "DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate.", "evidence": [ { "id": "F1LWX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1LWX6" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "F1LWX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1LWX6" } ] } ] }, { "uniprot_ac": "F1LWY1", "gene_name": "Hfm1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1LWY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1LWY1" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1LWY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1LWY1" } ] } ] }, { "uniprot_ac": "F1M298", "gene_name": "Fbh1", "activity": [ { "ec_number": "5.6.2.4", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1M298", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1M298" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1M298", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1M298" } ] } ] }, { "uniprot_ac": "F1M3J4", "gene_name": "Abcc4", "activity": [ { "ec_number": "7.6.2.2", "activity": "daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "F1M3J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1M3J4" } ] }, { "ec_number": "7.6.2.3", "activity": "an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+).", "evidence": [ { "id": "F1M3J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1M3J4" } ] }, { "ec_number": "7.6.2.2", "activity": "", "evidence": [ { "id": "F1M3J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1M3J4" } ] }, { "ec_number": "7.6.2.3", "activity": "", "evidence": [ { "id": "F1M3J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1M3J4" } ] }, { "ec_number": "7.6.2.-", "activity": "", "evidence": [ { "id": "F1M3J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1M3J4" } ] }, { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "F1M3J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1M3J4" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "F1M3J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1M3J4" } ] } ] }, { "uniprot_ac": "F1M5F3", "gene_name": "Mcm9", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1M5F3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1M5F3" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1M5F3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1M5F3" } ] } ] }, { "uniprot_ac": "F1M9L4", "gene_name": "Atp13a4", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "F1M9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1M9L4" } ] } ] }, { "uniprot_ac": "F1MA70", "gene_name": "Atp13a5", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "F1MA70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MA70" } ] } ] }, { "uniprot_ac": "F1MAM8", "gene_name": "Ddx20", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+).", "evidence": [ { "id": "F1MAM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAM8" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "F1MAM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAM8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1MAM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAM8" } ] }, { "ec_number": "3.6.1.15", "activity": "", "evidence": [ { "id": "F1MAM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/F1MAM8" } ] } ] }, { "uniprot_ac": "G3V681", "gene_name": "Mcm4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3V681", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3V681" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "G3V681", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3V681" } ] } ] }, { "uniprot_ac": "G3V6M7", "gene_name": "Ube2t", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "G3V6M7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3V6M7" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "G3V6M7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3V6M7" } ] } ] }, { "uniprot_ac": "G3V6W5", "gene_name": "Ifih1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3V6W5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3V6W5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3V6W5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3V6W5" } ] } ] }, { "uniprot_ac": "G3V8T5", "gene_name": "Ruvbl2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3V8T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3V8T5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "G3V8T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3V8T5" } ] } ] }, { "uniprot_ac": "G3V9M1", "gene_name": "Ddx23", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "G3V9M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3V9M1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3V9M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3V9M1" } ] } ] }, { "uniprot_ac": "G3V9T7", "gene_name": "Get3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "G3V9T7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/G3V9T7" } ] } ] }, { "uniprot_ac": "M0R9C6", "gene_name": "Ddx43", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "M0R9C6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/M0R9C6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "M0R9C6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/M0R9C6" } ] } ] }, { "uniprot_ac": "M0R9X1", "gene_name": "Dhx34", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "M0R9X1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/M0R9X1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "M0R9X1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/M0R9X1" } ] } ] }, { "uniprot_ac": "M0RCB1", "gene_name": "Hsc70-ps1", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "M0RCB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/M0RCB1" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "M0RCB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/M0RCB1" } ] } ] }, { "uniprot_ac": "P06761", "gene_name": "Hspa5", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "P06761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P06761" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P06761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P06761" } ] } ] }, { "uniprot_ac": "P08289", "gene_name": "Alpl", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P08289", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P08289" } ] }, { "ec_number": "3.9.1.1", "activity": "N-phosphocreatine + H2O = creatine + phosphate.", "evidence": [ { "id": "P08289", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P08289" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P08289", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P08289" } ] } ] }, { "uniprot_ac": "P28480", "gene_name": "Tcp1", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "P28480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P28480" } ] } ] }, { "uniprot_ac": "P34158", "gene_name": "Cftr", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "P34158", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P34158" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "P34158", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P34158" } ] } ] }, { "uniprot_ac": "P46462", "gene_name": "Vcp", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "P46462", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46462" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "P46462", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P46462" } ] } ] }, { "uniprot_ac": "P48721", "gene_name": "Hspa9", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + phosphate + H(+).", "evidence": [ { "id": "P48721", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48721" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P48721", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P48721" } ] } ] }, { "uniprot_ac": "P54777", "gene_name": "Pex6", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P54777", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P54777" } ] } ] }, { "uniprot_ac": 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