{ "uniprot_canonical_ac": "A0A0G2K2Z2-1", "uniprot_ac": "A0A0G2K2Z2", "uniprot_id": "A0A0G2K2Z2_RAT", "mass": { "chemical_mass": 52378.0, "monoisotopic_mass": 52378.0 }, "refseq": {}, "gene_names": [ { "name": "Inpp5k", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2", "id": "A0A0G2K2Z2" } ], "protein_names": [ { "name": "Inositol polyphosphate 5-phosphatase K", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2/entry#names_and_taxonomy", "id": "A0A0G2K2Z2" }, { "name": "3.1.3.36", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2/entry#names_and_taxonomy", "id": "A0A0G2K2Z2" }, { "name": "3.1.3.56", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2/entry#names_and_taxonomy", "id": "A0A0G2K2Z2" }, { "name": "3.1.3.86", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2/entry#names_and_taxonomy", "id": "A0A0G2K2Z2" }, { "name": "Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2/entry#names_and_taxonomy", "id": "A0A0G2K2Z2" }, { "name": "Phosphatidylinositol-4,5-bisphosphate 5-phosphatase", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2/entry#names_and_taxonomy", "id": "A0A0G2K2Z2" }, { "name": "Skeletal muscle and kidney-enriched inositol phosphatase", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2/entry#names_and_taxonomy", "id": "A0A0G2K2Z2" } ], "function": [ { "annotation": "Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate. Negatively regulates assembly of the actin cytoskeleton. Controls insulin-dependent glucose uptake among inositol 3,4,5-trisphosphate phosphatases; therefore, is the specific regulator for insulin signaling in skeletal muscle.", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K5K7", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K5K7#function" }, { "database": "UniProtKB", "id": "ARBA00057102", "url": "https://www.uniprot.org/uniprotkb/ARBA00057102#function" }, { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2#function" } ] } ], "disease": [ { "disease_id": "DOID:0050588", "recommended_name": { "id": "DOID:0050588", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050588", "name": "muscular dystrophy-dystroglycanopathy type B1", "description": "A congenital muscular dystrophy characterized by muscle weakness, cognitive impairment and brain abnormalities and has_material_basis_in mutation to the POMT1 gene that encodes O-mannosyltransferase." }, "synonyms": [ { "id": "DOID:0050588", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050588", "name": "CMD due to dystroglycanopathy", "description": "" }, { "id": "DOID:0050588", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050588", "name": "Muscular dystrophy-dystroglycanopathy congenital with impaired intellectual development B1", "description": "" }, { "id": "MONDO:0013159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013159", "name": "muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B1", "description": "" }, { "id": "MONDO:0013159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013159", "name": "congenital muscular dystrophy-POMT1 related", "description": "" }, { "id": "MONDO:0013159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013159", "name": "MDDGB1", "description": "" }, { "id": "MONDO:0013159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013159", "name": "muscular dystrophy, congenital, Pomt1-related", "description": "" }, { "id": "MONDO:0013159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013159", "name": "muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B, 1", "description": "" }, { "id": "MONDO:0013159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013159", "name": "muscular dystrophy-dystroglycanopathy (congenital with mental retardation), type B, 1", "description": "" }, { "id": "MIM:613155", "resource": "MIM", "url": "https://www.omim.org/entry/613155", "name": "Muscular dystrophy-dystroglycanopathy congenital with impaired intellectual development B1", "description": "Muscular dystrophy-dystroglycanopathy congenital with impaired intellectual development B1" } ], "unlinked_id_list": [], "evidence": [ { "id": "0050588", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0050588" } ] }, { "disease_id": "DOID:0080197", "recommended_name": { "id": "DOID:0080197", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080197", "name": "congenital muscular dystrophy with cataracts and intellectual disability", "description": "A congenital muscular dystrophy characterized by onset of progressive muscle weakness in early childhood with autosomal recessive inheritance that has_material_basis_in homozygous or compound heterozygous mutation in the INPP5K gene (607875) on chromosome 17p13." }, "synonyms": [ { "id": "MONDO:0024607", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024607", "name": "congenital muscular dystrophy with cataracts and intellectual disability", "description": "A congenital muscular dystrophy characterized by onset of progressive muscle weakness in early childhood with autosomal recessive inheritance that has material basis in homozygous or compound heterozygous mutation in the INPP5K gene (607875) on chromosome 17p13." }, { "id": "MONDO:0024607", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024607", "name": "MDCCAID", "description": "" }, { "id": "MONDO:0024607", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024607", "name": "muscular dystrophy, congenital, with cataracts and intellectual disability", "description": "" }, { "id": "MIM:617404", "resource": "MIM", "url": "https://www.omim.org/entry/617404", "name": "Muscular dystrophy, congenital, with cataracts and impaired intellectual development", "description": "Muscular dystrophy, congenital, with cataracts and impaired intellectual development" } ], "unlinked_id_list": [], "evidence": [ { "id": "0080197", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:0080197" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "gene": [ { "name": "Inpp5k", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2", "locus": { "chromosome": "10", "start_pos": 60496773, "end_pos": 60475897, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000056954", "url": "https://www.ensembl.org/id/ENSRNOG00000056954" } ] } } ], "crossref": [ { "id": "RGD:1359130", "url": "https://alliancegenome.org/gene/RGD:1359130", "database": "AGR", "categories": [ "Protein Classification" ] }, { "id": "A0A0G2K2Z2", "url": "https://alphafold.ebi.ac.uk/entry/A0A0G2K2Z2", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSRNOG00000056954", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000056954", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR000300", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000300", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036691", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036691", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046985", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046985", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "NSECQHI", "url": "https://omabrowser.org/oma/group/NSECQHI/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR11200", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11200", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11200:SF117", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11200:SF117", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF17751", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF17751", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF22669", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF22669", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-1660499", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1660499", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "1359130", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1359130", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2K2Z2-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2K5K7", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K5K7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2K5K7-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K5K7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTTASLRKPSAPKELMLSIHVVTWNVASAAPTVDLSDLLQLNNEDLNLDIYIIGLQEMNYGIISLLSDAAFEDPWSSFFMDMLSPLNLVKISQVRMQGLLLLVFAKYQHLPYIQIISTKSIPTGLYGYWGNKGGINICLKLYGYYVSIVNCHLPPHMYNNDQRLEHFDRILESLTFEGYDVPNILDHDLILWFGDMNFRIEDFGLLFVQECITKKRYKELWEKDQLFIAKKQDQLLREFQEGPLLFPPTYKFDRHSNNYDTSEKKRKPAWTDRILWRLKRQPAKANPSGFLLTQKDYVSHMTYSISDHKPVTGTFDLELNPLMSVPLITMMPEYLWTKENDMLINYTSTPEFLSSPWDWIGLYKVIWQVGMRHINDYVSYVWVGDNQVSRGNNPNQVYINISAIPDTEEQFLLCYYSNNLHSIVGISQPFKIPSGFFLREDTLSELEPQL", "length": 450, "header": "tr|A0A0G2K2Z2-1|A0A0G2K2Z2_RAT Isoform 1 of Inositol polyphosphate 5-phosphatase K OS=Rattus norvegicus OX=10116 GN=Inpp5k PE=1 SV=2 CANONICAL=A0A0G2K2Z2-1" }, "isoforms": [ { "isoform_ac": "A0A0G2K2Z2-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2/entry#A0A0G2K2Z2-1", "sequence": { "sequence": "MTTASLRKPSAPKELMLSIHVVTWNVASAAPTVDLSDLLQLNNEDLNLDIYIIGLQEMNYGIISLLSDAAFEDPWSSFFMDMLSPLNLVKISQVRMQGLLLLVFAKYQHLPYIQIISTKSIPTGLYGYWGNKGGINICLKLYGYYVSIVNCHLPPHMYNNDQRLEHFDRILESLTFEGYDVPNILDHDLILWFGDMNFRIEDFGLLFVQECITKKRYKELWEKDQLFIAKKQDQLLREFQEGPLLFPPTYKFDRHSNNYDTSEKKRKPAWTDRILWRLKRQPAKANPSGFLLTQKDYVSHMTYSISDHKPVTGTFDLELNPLMSVPLITMMPEYLWTKENDMLINYTSTPEFLSSPWDWIGLYKVIWQVGMRHINDYVSYVWVGDNQVSRGNNPNQVYINISAIPDTEEQFLLCYYSNNLHSIVGISQPFKIPSGFFLREDTLSELEPQL", "length": 450, "header": "tr|A0A0G2K2Z2-1|A0A0G2K2Z2_RAT Isoform 1 of Inositol polyphosphate 5-phosphatase K OS=Rattus norvegicus OX=10116 GN=Inpp5k PE=1 SV=2 CANONICAL=A0A0G2K2Z2-1" }, "locus": { "chromosome": "10", "start_pos": 60495585, "end_pos": 60476021, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000090481.2", "url": "https://www.ensembl.org/id/ENSRNOT00000090481.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000072437.2", "url": "https://www.ensembl.org/id/ENSRNOP00000072437.2" } ] } }, { "isoform_ac": "A0A0G2K5K7-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2/entry#A0A0G2K5K7-1", "sequence": { "sequence": "QKTKNKKKPKSMKQTCRHISNDHSPTVDLSDLLQLNNEDLNLDIYIIGLQEMNYGIISLLSDAAFEDPWSSFFMDMLSPLNLVKISQVRMQGLLLLVFAKYQHLPYIQIISTKSIPTGLYGYWGNKGGINICLKLYGYYVSIVNCHLPPHMYNNDQRLEHFDRILESLTFEGYDVPNILDHDLILWFGDMNFRIEDFGLLFVQECITKKRYKELWEKDQLFIAKKQDQLLREFQEGPLLFPPTYKFDRHSNNYDTSEKKRKPAWTDRILWRLKRQPAKANPSGFLLTQKDYVSHMTYSISDHKPVTGTFDLELNPLMSVPLITMMPEYLWTKENDMLINYTSTPEFLSSPWDWIGLYKVGMRHINDYVSYVWVGDNQVSRGNNPNQVYINISAIPDTEEQFLLCYYSNNLHSIVGISQPFKIPSGFFLREDTLSELEPQL", "length": 440, "header": "tr|A0A0G2K5K7-1|A0A0G2K5K7_RAT Computationally mapped isoform of Inositol polyphosphate 5-phosphatase K OS=Rattus norvegicus OX=10116 GN=Inpp5k PE=1 SV=2 CANONICAL=A0A0G2K2Z2-1" }, "locus": { "chromosome": "10", "start_pos": 60495585, "end_pos": 60477822, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000084496.2", "url": "https://www.ensembl.org/id/ENSRNOT00000084496.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000073462.2", "url": "https://www.ensembl.org/id/ENSRNOP00000073462.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-RNO-1660499", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1660499", "resource": "Reactome", "description": "Synthesis of PIPs at the plasma membrane" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A2R8QKI3-1", "protein_name": "Inositol polyphosphate 5-phosphatase K isoform X1", "gene_name": "inpp5kb", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSDTFDVPRMRSDSMSTMTSQSTSARFILRQRLAQLLTCLEDLSSDDEANEEVSRTLDEAFNLCGRYSNRESFRLHMVTWNVGTAEPPADVRSLLQLDSQPTTDLYVIGLQEVNATPVRYISDLIAEDTWSHLLMETLAPEGYIKVTSVRMQGLLLILFAKQVHLPFIRDIQSTYTRTGLFGYWGNKGGISVRFSFYGEMLCFLNCHLAAHMNYALQRMDEFEYILDTQEFDMFNTPQVLDHKVVFWFGDLNFRIADHGMHFLRSSINNSRFNLLWDRDQLSMLKKKEPILQEFEEGPLRFKPTYKFDRFSETYNTRAPRTWFGLTGKKRKPAWTDRILWRIKPKATEIEDEKSSTASSADDDEFSVKVTQDMYTCDVSYGVSDHKPVIGTFNLEMRKKVETPLVALTVEGIWSADEDAIFTYTILENFESSTFDWIGLYKIGFKSASDYSTFAWVKDDEVAANGEVVMVQMNKNELPLLAGDYVLGYFSTNMQTLIAFSPNFQILESKRAVMEGLVQENINGLEK", "length": 526 }, "evidence": [ { "id": "FB:FBgn0034179", "url": "https://alliancegenome.org/gene/FB:FBgn0034179#orthology", "database": "AGR" }, { "id": "HGNC:33882", "url": "https://alliancegenome.org/gene/HGNC:33882#orthology", "database": "AGR" }, { "id": "MGI:1194899", "url": "https://alliancegenome.org/gene/MGI:1194899#orthology", "database": "AGR" }, { "id": "FB:FBgn0030761", "url": "https://alliancegenome.org/gene/FB:FBgn0030761#orthology", "database": "AGR" }, { "id": "RGD:1359130", "url": "https://alliancegenome.org/gene/RGD:1359130#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-100408-3", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-100408-3#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8M1RLT2-1", "protein_name": "Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A", "gene_name": "inpp5jb", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MEAEQQIQSESKSNDLASSTPPKAPSEASPPAVPSAPARPRRPQRSPRVEGSIDVSEPKPPESPKPSSHDEPNAEAQAQLRVHAPPAALKLSGHASVARSHISMRAASLPQAPSYKPPSTESVVHPQRALSVAGTADTQPQVAEDFRIHIVTWNVGSAMPPEDITNLLGLNVGDGNTDMYIIGLQEVNSMINKRLKDVLFTDQWSEVCMDALSPFGYVLATSQRMQGMLLLVFAKYFHLPFLRGIQTQTTRTGLGGIWGNKGGVSARMTVFGHSICFLNCHLPAHMENTEQRMEDFESILQQQQFDGQAATGVLDHDVVFWFGDLNFRIEDLEMQVVKGAIDNNKLSVLWEKDQLNIAKDSETVLEGFHEGPLKFPPTYKFDVGTDTYDTSGKKRMPAWTDRILWRLRPMAQVSNSTSKRSSLSGLTSGTRVSQHFYRSHMEYTVSDHKPVSSVFTLQFPYKVDMPLVTIFVEDEWREISDAVAKFKVAPNFARSSWDWIGIYKVGFKHHKDYVAYTWAKQEESDFLRQEHQVNFTEEELPKESGDFILGYYSNNTSSIVGITEPFQIQLPASAAAGLSPSDSSDFTSDDEVKKPDSGDSSPETEDPVSSRLTEEQMAKPSRPHARPRHGKHHAGSAVQPSDEPENSGKAAAEPEEP", "length": 657 }, "evidence": [ { "id": "FB:FBgn0034179", "url": "https://alliancegenome.org/gene/FB:FBgn0034179#orthology", "database": "AGR" }, { "id": "FB:FBgn0030761", "url": "https://alliancegenome.org/gene/FB:FBgn0030761#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8M3AHJ9-1", "protein_name": "Inositol polyphosphate 5-phosphatase Ka isoform X1", "gene_name": "inpp5ka", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSSSMEEISEYFSEKLQRQRSDSAASSSTQSTSSRQHVRQRLAMLLTCVDDLDTDHKLQTQVAKTLDEAFLVCRQIAGRPKKNPFRLYVVTWNVATAEPPDDVNALLQLNSPKKPDLYVIGLQEVRAAPLKFVSDLAFEDSWSHLFMDTLSPLHYIKVSSIRMQGLLLLFFSKLEHVPFIRDIQVTYTRTGLYGYWGNKGGVTIRLSFYGHMLCFLNCHLTAHMNYASQRVDEFEHILDAQNFNTKNTPHVLDHKVVFWFGDLNFRIEDHGMLFVRNCITSQRFNLLWPKDQLTMMKQKEVILQKFEEGPLDFQPTYKFDLNSDNYDTRVQTTWFGFNGKKRKPAWCDRILWRVKPKASLTENTNEEEPEKQQEEEREDEFPLKMTQEYYTSKMEYGISDHKPVIGIFRLELRKMYETPLVQVFAEGEWSADFDAVITYRLLQAFASSAWDWIGLYKVGFKSVSDYITYAWVKDDQVSFNEELFQVYMNKDEIPVLGGECVLCYYSSNLQCIVGISQPFKVQESRAAIEEGLVPENINGLNQALAS", "length": 546 }, "evidence": [ { "id": "FB:FBgn0034179", "url": "https://alliancegenome.org/gene/FB:FBgn0034179#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-070410-101", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-070410-101#orthology", "database": "AGR" }, { "id": "HGNC:33882", "url": "https://alliancegenome.org/gene/HGNC:33882#orthology", "database": "AGR" }, { "id": "MGI:1194899", "url": "https://alliancegenome.org/gene/MGI:1194899#orthology", "database": "AGR" }, { "id": "FB:FBgn0030761", "url": "https://alliancegenome.org/gene/FB:FBgn0030761#orthology", "database": "AGR" }, { "id": "RGD:1359130", "url": "https://alliancegenome.org/gene/RGD:1359130#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8V1AJM9-1", "protein_name": "Inositol polyphosphate-5-phosphatase K", "gene_name": "INPP5K", "tax_id": 9031, "organism": "Gallus gallus", "sequence": { "sequence": "MDSEQHSSAQRDAVRELRLHLVTWNVGTASPPPDVTSLLQLDSPSPAIDMYVIGLQEVNSRITNFLSDLVFDDPWSIFFMTVLSPLGYIKLSSIRMQGLLLLIFVKHDHLPFIRDVRTNYTRTGLYGYWGNKGGVTVRMSLYGHTICFINCHLPAHMENTEQRLDDFEKILEMQFEEENVPSTLDHDVLFWFGDLNFRIADYGIHFVRESINNKRYNLLWEKDQLNMAKKKEAFLQEFIEGPLQFKPTYKFDLHSDVYDTREQKSLFWFNEKKRKPAWTDRILWRVKSLCQHASKEDDFSEEEQTISVTLNNYISHMSYGISDHKPVTGTFGIELKPLLSDPLVTLSPEGEWSSERDVFISYSAVPGFPSSAWDWIGLFKVTFRHANDYVTYAWVEDDEISSNEDSKQVYMSAAEIPDMGGKFLLCYYSNNLQSIVGISQPFQIQPNRTSIGKDLAQEENAWMQKPDNLESHNEF", "length": 475 }, "evidence": [ { "id": "A0A0G2K2Z2", "url": "https://omabrowser.org/oma/group/A0A0G2K2Z2/", "database": "OMA" } ], "glygen_name": "Chicken", "common_name": "Chicken" }, { "uniprot_canonical_ac": "G3HTF6-1", "protein_name": "Inositol polyphosphate 5-phosphatase K", "gene_name": "Inpp5k", "tax_id": 10029, "organism": "Cricetulus griseus", "sequence": { "sequence": "MKSAACLRRPSTPKVSVLSIHVVTWNVASAAPTVDLSDLLQLNSQDLNLDIYIIGLQEMNSGIISLLSDAAFEDPWSTLFMDVLSRLHFVKVSQVRMQGLLLLVFAKYQHLPFIQIISTKSIPTGFYGYWGNKGGVNICLKLYGYYVSIINCHLPPHMSNNDQRLEHFDRILESQTFEGSDVPNILDHDLILWFGDMNFRIEDFGLLFVQECITKQYYQELWEKDQLRIAKRRDPLLREFQEGPLLFPPTYKFDRHSNNYDTSEKKRKPAWTDRILWRLKRQPQTSPLVSRLPSSYFSLTLKSYVSHMTYSISDHKPVTGTFNLELNPRMSVPLITMMPECLWTMENDMLISYTSTPEFLSSPWDWIGLYKVGMRHINDYVSYAWVGDNQVSYGNHPHQVYINISNVPETEDQFLLCYYSNNLHSVVGISQPFKIPLRFFLRDDTLSDPQI", "length": 451 }, "evidence": [ { "id": "A0A0G2K2Z2", "url": "https://omabrowser.org/oma/group/A0A0G2K2Z2/", "database": "OMA" } ], "glygen_name": "Hamster", "common_name": "Chinese hamster" }, { "uniprot_canonical_ac": "I3LIY2-1", "protein_name": "Inositol polyphosphate 5-phosphatase K", "gene_name": "INPP5K", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAATNPQTEPRSRTLSIHVVTWNVASAAPPPDLSDLLQLHTPNLNLDVYVIGLQEMNCGIMSLLSDTAFEDPWSSFFMDVLSPLSFVKVSSVRMQGLLLLVFAKYQHLPFIQILSAKSTPTGLFGYWGNKGGVNIFLKLYGYYVSIINCHLPPHMANNDQRLEHFDRILEMQNFEAQDIPNILDHDLILWFGDMNFRIEDFGLHFVRESIKHQCYSDLWEKDQLSIAKRHDPLLREFQEGPLLFPPTYKFDKNSNNYDTSEKKRKPAWTDRILWRLKRQPQADCHPPTLPGPHFSLVLRSYVSHMMYSISDHKPVTGTFDLELKPLVSAPLITLLPEGPCTTESDLLISYSLASDFLSSPWDWIGLYKVGLRHINDYVSYVWVGDNQVSFGDQLNQVYISLSDIPETEDGFLLFYYSNSLRSVVGISRPFKIQPRSFLEQDSLDEAQPQI", "length": 450 }, "evidence": [ { "id": "A0A0G2K2Z2", "url": "https://omabrowser.org/oma/group/A0A0G2K2Z2/", "database": "OMA" } ], "glygen_name": "Pig", "common_name": "Pig" }, { "uniprot_canonical_ac": "M9PHS8-1", "protein_name": "3.1.3.36", "gene_name": "Dmel\\CG9784", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSQTEASKTPKIPDSEPDGSKGKGKQQLETYRVYVVTWNVGSRFPDNISLRHLLGLQDVTVDKDTKETNAHLPDIYALGLQEVNAQPQQQVLGLFKEDPWTHKAKELLRNYDYVAVKTEQMQGLLLSMFVRRQHVEHLQDIEAEFTRTGFGGIWGNKGAVSVRFTLYGCGLAFVVAHLTAHDHMMDERIEDYKQILENHHYHVKRYREIYDHDYVFWFGDLNFRLQGSDSSTEVRELVRDESQHEALIQRDQLYQVREKSQLAFQVLQERLPAFPPTFKFREGTSEYDLKRRPAWTDRIMYAVQPLNRQPGMQLSIEQCSYKSHPLYTISDHKPVTSDFTIKLYPNVRAPGVVFSPLSLWKIGDENTVEYHKQAEFDEGSNDWIGIFPSEYASLADYVAYEYVNQAESPSSSDSNHQPDPFETPSHHRRGRHHHRNRQRQRRHQEANAQELVRLDFADDVELRHGEQYLLIYFRSTGVRGVTSLAGVSGVFVAEKRHGSPHRTEYHVDXLAEALDIFIL", "length": 519 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-070410-101", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-070410-101#orthology", "database": "AGR" }, { "id": "HGNC:33882", "url": "https://alliancegenome.org/gene/HGNC:33882#orthology", "database": "AGR" }, { "id": "MGI:1194899", "url": "https://alliancegenome.org/gene/MGI:1194899#orthology", "database": "AGR" }, { "id": "FB:FBgn0030761", "url": "https://alliancegenome.org/gene/FB:FBgn0030761#orthology", "database": "AGR" }, { "id": "RGD:1359130", "url": "https://alliancegenome.org/gene/RGD:1359130#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-100408-3", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-100408-3#orthology", "database": "AGR" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "P59644-1", "protein_name": "Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A", "gene_name": "Inpp5j", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEGQTRSGSARPGTRTGLGPLPGTHGVLQAEIPSKKVNSSFQLPAKNSGPASSEPRLTLAPVGPRAAVSPPSERPRLVLSSPRPVLAPLSIAGEQKRPPPPHSSNRAAKSVGQLVVSAAAASKPPPVASVSILAPKSLGQLVISASAMPRPSPAPLGSVLTPTSRDQKQLSPTSVGPKPALATSGLSLALASQEQPPQSPSSPSPVPSPVLSPSQEGHLAAASVTSTPASERQLPARQKDTAVPRPTPPADKCLYTPERAAGPATSPPRAQAFSDPRLSPSFRARPEAPRHSPEDPVLPPPPQTLPLDVSPGLPESGTRSPGLLSPTFRPGIPSSQTVPPPLPKPPRSPSRSPSRSPNRSPCLPPAPEVALPKPVTQAAGSGRCPSPNLQAQESPAAATTTTSPTSSWSAQPTCKSDPGFRITVVTWNVGTAMPPDDVTSLLHLGSGHDNDGADMIAIGLQEVNSMINKRLKDALFTDQWSELFMDALGPFNFVLVSTVRMQGVILLLFAKYYHLPFLRDVQTDCTRTGLGGYWGNKGGVSVRLAAFGHMLCFLNCHLPAHMDKAEQRKDNFQTILSLQQFQGPGAHGILDHDLVFWFGDLNFRIESYDLHFVKFAIDSNQLHQLWEKDQLNMAKNTWPILKGFQEGPLNFAPTFKFDVGTNKYDTSAKKRKPAWTDRILWKVKAPSGGPSPSGRESHRLQVTQHSYRSHMEYTVSDHKPVAAQFILQFAFRDDVPLVRLEVADEWARPEQAVVRYRVETVFARSSWDWIGLYRVGFRHCKDYVAYVWAKHEEVDGNIYQVTFSEESLPKGHGDFILGYYSHHHSILIGVTEPFQISLPTSESASSSTDSSGTSSEGEDDSTLELLAPKSRSPSPGKSKRHRSRSPGLARFPSLALHPSSRERRGGSRSPSPQSRQLPRVAPDRGHSSSSRGSSEEGPSGLPGPWAFPPSVPRSLGLLPALRLETVDPGGGGSWGADQEAPDPNSLSPSPQGRLGLEEGGLGP", "length": 1003 }, "evidence": [ { "id": "FB:FBgn0034179", "url": "https://alliancegenome.org/gene/FB:FBgn0034179#orthology", "database": "AGR" }, { "id": "FB:FBgn0030761", "url": "https://alliancegenome.org/gene/FB:FBgn0030761#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q08227-1", "protein_name": "Phosphatidylinositol 4,5-bisphosphate 5-phosphatase INP54", "gene_name": "INP54", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MNKTNWKVSVTTFNCGKEFPVENSKAIVKQLLFPYDDGISQLELQDLYVLGFQEVVPIWQGSFPAVNRDLIDRITTTAVNCLNEKVSATQGDEQYSCLGVNSLGAITIIVLYNNNALKVKDDILKRNGKCGWFGTHLKGGTLISFQMTRNGEENWERFSYICAHLNANEGVNNRNQRIDDYKRIMSEVCDSEVAKSDHFFFLGDLNFRVTSTYDPTTNYSSTTTLRRLLENHEELNLLRKGEDEPLCKGFQELKITFPPTYKFKLFEKETYNTKRIPSWCDRILYKSYAVPTFAQEGTYHSVPRSNALLFSDHQPVNLTVRLPRSTGTPVPLSLHIEKYPLSWSSGLIGQIGDAVIGYCGWLVTKNVHYWILGSLLLYLLLKIL", "length": 384 }, "evidence": [ { "id": "FB:FBgn0034179", "url": "https://alliancegenome.org/gene/FB:FBgn0034179#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-070410-101", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-070410-101#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-100408-3", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-100408-3#orthology", "database": "AGR" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q15735-1", "protein_name": "Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A", "gene_name": "INPP5J", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEGQSSRGSRRPGTRAGLGSLPMPQGVAQTGAPSKVDSSFQLPAKKNAALGPSEPRLALAPVGPRAAMSASSEGPRLALASPRPILAPLCTPEGQKTATAHRSSSLAPTSVGQLVMSASAGPKPPPATTGSVLAPTSLGLVMPASAGPRSPPVTLGPNLAPTSRDQKQEPPASVGPKPTLAASGLSLALASEEQPPELPSTPSPVPSPVLSPTQEQALAPASTASGAASVGQTSARKRDAPAPRPLPASEGHLQPPAQTSGPTGSPPCIQTSPDPRLSPSFRARPEALHSSPEDPVLPRPPQTLPLDVGQGPSEPGTHSPGLLSPTFRPGAPSGQTVPPPLPKPPRSPSRSPSHSPNRSPCVPPAPDMALPRLGTQSTGPGRCLSPNLQAQEAPAPVTTSSSTSTLSSSPWSAQPTWKSDPGFRITVVTWNVGTAMPPDDVTSLLHLGGGDDSDGADMIAIGLQEVNSMLNKRLKDALFTDQWSELFMDALGPFNFVLVSSVRMQGVILLLFAKYYHLPFLRDVQTDCTRTGLGGYWGNKGGVSVRLAAFGHMLCFLNCHLPAHMDKAEQRKDNFQTILSLQQFQGPGAQGILDHDLVFWFGDLNFRIESYDLHFVKFAIDSDQLHQLWEKDQLNMAKNTWPILKGFQEGPLNFAPTFKFDVGTNKYDTSAKKRKPAWTDRILWKVKAPGGGPSPSGRKSHRLQVTQHSYRSHMEYTVSDHKPVAAQFLLQFAFRDDMPLVRLEVADEWVRPEQAVVRYRMETVFARSSWDWIGLYRVGFRHCKDYVAYVWAKHEDVDGNTYQVTFSEESLPKGHGDFILGYYSHNHSILIGITEPFQISLPSSELASSSTDSSGTSSEGEDDSTLELLAPKSRSPSPGKSKRHRSRSPGLARFPGLALRPSSRERRGASRSPSPQSRRLSRVAPDRSSNGSSRGSSEEGPSGLPGPWAFPPAVPRSLGLLPALRLETVDPGGGGSWGPDREALAPNSLSPSPQGHRGLEEGGLGP", "length": 1006 }, "evidence": [ { "id": "FB:FBgn0034179", "url": "https://alliancegenome.org/gene/FB:FBgn0034179#orthology", "database": "AGR" }, { "id": "FB:FBgn0030761", "url": "https://alliancegenome.org/gene/FB:FBgn0030761#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5EAF2-1", "protein_name": "Type IV inositol polyphosphate 5-phosphatase 11", "gene_name": "IP5P11", "tax_id": 3702, "organism": "Arabidopsis thaliana", "sequence": { "sequence": "MPTMGNKNSMCGLKRFPNYKKSPIGSFAKNSSSHDGIKTIEAVNSCSFSRKADLCIRIITWNMNGNVSYEDLVELVGKERKFDLLVVGLQEAPKANVDQLLQTASSPTHELLGKAKLQSVQLYLFGPKNSHTLVKELKAERYSVGGCGGLIGRKKGAVAIRINYDDIKMVFISCHLSAHAKKVDQRNTELRHIANSLLPRDKRKRDLTVWLGDLNYRIQDVSNHPVRSLIQNHLQSVLVSKDQLLQEAERGEIFKGYSEGTLGFKPTYKYNVGSSDYDTSHKIRVPAWTDRILFKIQDTDNIQATLHSYDSIDQVYGSDHKPVKADLCLKWVNS", "length": 334 }, "evidence": [ { "id": "A0A0G2K2Z2", "url": "https://omabrowser.org/oma/group/A0A0G2K2Z2/", "database": "OMA" } ], "glygen_name": "Arabidopsis", "common_name": "Mouse-ear cress" }, { "uniprot_canonical_ac": "Q7K161-1", "protein_name": "LD06095p", "gene_name": "IPP", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MVTATAIADLCIFLLTWNVGTHTPRNQDLSSLLSLNGTTTCPDNQLPDIYVIGFQEVSTTPQVLKIFNDDPWVLKIADSLSDHQFVKVDSKQLQGILITMFAQHKHIPHMKEIETEATRTGLGGLWGNKGAVSIRLSLYGTGVAFVCSHLAAHDEKLKERIEDYHQIVDNHKYNAQGYRRIFDHDFVFWFGDLNFRLSGDMSAWDVRTDVENQRYADLLKLDQLNLLREKGNAFSLLEEQQPNFAPTFKFVEGTNDYNLKRRPAWCDRILHRVQSNIYPGITLSANQLSYQSHMDYTLSDHKPVSATFNYKVEAANQTYTDEELHEMTHGSASSPATPNVSLSFAFVVFVAVSYTQL", "length": 357 }, "evidence": [ { "id": "FB:FBgn0034179", "url": "https://alliancegenome.org/gene/FB:FBgn0034179#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-070410-101", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-070410-101#orthology", "database": "AGR" }, { "id": "HGNC:33882", "url": "https://alliancegenome.org/gene/HGNC:33882#orthology", "database": "AGR" }, { "id": "MGI:1194899", "url": "https://alliancegenome.org/gene/MGI:1194899#orthology", "database": "AGR" }, { "id": "RGD:1359130", "url": "https://alliancegenome.org/gene/RGD:1359130#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-100408-3", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-100408-3#orthology", "database": "AGR" }, { "id": "A0A0G2K2Z2", "url": "https://omabrowser.org/oma/group/A0A0G2K2Z2/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q8C5L6-1", "protein_name": "Inositol polyphosphate 5-phosphatase K", "gene_name": "Inpp5k", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MQHGDRNTPGYREGIMSAVSLRRPSAPKGFALSVHVVTWNVASAAPTVDLSDLLQLNNQDLNLDIYIIGLQEMNFGIISLLSDAAFEDPWSSLFMDMLSPLNFVKISQVRMQGLLLLVFAKYQHLPYIQIISTKSTPTGLYGYWGNKGGVNVCLKLYGYYVSIINCHLPPHMYNNDQRLEHFDRILESLTFEGYDVPNILDHDLILWFGDMNFRIEDFGLLFVQESITRKYYKELWEKDQLFIAKKNDQLLREFQEGPLLFPPTYKFDRHSNNYDTSEKKRKPAWTDRILWRLKRQPSQASPLASSVPTSYFLLTLKNYVSHMAYSISDHKPVTGTFDLELNPLMSVPLITMMPEHLWTMENDMLISYTSTPEFLSSSWDWIGLYKVGMRHINDYVAYVWVGDNQVSYGNNPNQVYINISAIPDTEDQFLLCYYSNNLHSVVGISQPFKIPIRSFLREDTLYEPEPQI", "length": 468 }, "evidence": [ { "id": "FB:FBgn0034179", "url": "https://alliancegenome.org/gene/FB:FBgn0034179#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-070410-101", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-070410-101#orthology", "database": "AGR" }, { "id": "HGNC:33882", "url": "https://alliancegenome.org/gene/HGNC:33882#orthology", "database": "AGR" }, { "id": "MGI:1194899", "url": "https://alliancegenome.org/gene/MGI:1194899#orthology", "database": "AGR" }, { "id": "FB:FBgn0030761", "url": "https://alliancegenome.org/gene/FB:FBgn0030761#orthology", "database": "AGR" }, { "id": "RGD:1359130", "url": "https://alliancegenome.org/gene/RGD:1359130#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-100408-3", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-100408-3#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9BT40-1", "protein_name": "Inositol polyphosphate 5-phosphatase K", "gene_name": "INPP5K", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSSRKLSGPKGRRLSIHVVTWNVASAAPPLDLSDLLQLNNRNLNLDIYVIGLQELNSGIISLLSDAAFNDSWSSFLMDVLSPLSFIKVSHVRMQGILLLVFAKYQHLPYIQILSTKSTPTGLFGYWGNKGGVNICLKLYGYYVSIINCHLPPHISNNYQRLEHFDRILEMQNCEGRDIPNILDHDLIIWFGDMNFRIEDFGLHFVRESIKNRCYGGLWEKDQLSIAKKHDPLLREFQEGRLLFPPTYKFDRNSNDYDTSEKKRKPAWTDRILWRLKRQPCAGPDTPIPPASHFSLSLRGYSSHMTYGISDHKPVSGTFDLELKPLVSAPLIVLMPEDLWTVENDMMVSYSSTSDFPSSPWDWIGLYKVGLRDVNDYVSYAWVGDSKVSCSDNLNQVYIDISNIPTTEDEFLLCYYSNSLRSVVGISRPFQIPPGSLREDPLGEAQPQI", "length": 448 }, "evidence": [ { "id": "FB:FBgn0034179", "url": "https://alliancegenome.org/gene/FB:FBgn0034179#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-070410-101", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-070410-101#orthology", "database": "AGR" }, { "id": "HGNC:33882", "url": "https://alliancegenome.org/gene/HGNC:33882#orthology", "database": "AGR" }, { "id": "MGI:1194899", "url": "https://alliancegenome.org/gene/MGI:1194899#orthology", "database": "AGR" }, { "id": "FB:FBgn0030761", "url": "https://alliancegenome.org/gene/FB:FBgn0030761#orthology", "database": "AGR" }, { "id": "RGD:1359130", "url": "https://alliancegenome.org/gene/RGD:1359130#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-100408-3", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-100408-3#orthology", "database": "AGR" }, { "id": "A0A0G2K2Z2", "url": "https://omabrowser.org/oma/group/A0A0G2K2Z2/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9JMC1-1", "protein_name": "Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A", "gene_name": "Inpp5j", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEGQSRSGSAKSGTRTGLGPLPGTHGALQTGTPSKKVNSSFQLPAKNTGPTPSEPRLALAPVGPRAAVSPPSERPRLALSSPRPILAPLSTAGEQKRPPPHRSSKPAPTSVGQLVVSAAAGPKPPPVASVSILAPKSLGQLVISASAMPRPTPAPLGPILSPTSRDQKQLSPTSVGPKPALATSGLSLALASQEQPPQSPSSPSPVPSPVLSPSQESHLAPATVTSTPASERQLPARQKDTAVRRPIPPADGCLHTPVQAAGLATSPPRAQTSSDPRLSPSFRARPEAPRHSPEDPVLPPPPQTLPLDVSSGLPESGTRSPGLLSPTFRPGIPSNQTVPPPLPKPPRSPSRSPSRSPNRSPCVPPAPEVALPRPVTQGAGPGKCPSPNLQTQESPVATATSPTSSWSAQPTCKSDPGFRITVVTWNVGTAMPPDDVTSLLHLGGGHDSDGADMIAIGLQEVNSMINKRLKDALFTDQWSELFMDALGPFNFVLVSTVRMQGVILLLFAKYYHLPFLRDVQTDCTRTGLGGYWGNKGGVSVRLAAFGHMLCFLNCHLPAHMDKAEQRKDNFQTILSLQQFQGPGAHGILDHDLVFWFGDLNFRIESYDLHFVKFAIDSNQLHQLWEKDQLNMAKNTWPILKGFQEGPLNFAPTFKFDVGTNKYDTSAKKRKPAWTDRILWKVKAPSGGPSPSGRESHRLQVTQHSYRSHMEYTVSDHKPVAARFLLQFAFRDDVPLVRLEVADEWARPEQAVVRYRVETVFARSSWDWIGLYRVGFRHCKDYVAYVWAKHEEVDGNIYQVTFSEESLPKGHGDFILGYYSHHHSILIGVTEPFQISLPTSESASSSTDSSGTSSEGEDDSTLELLAPKSRSPSPGKSKRHRSRSPGLARFPSLALRPSSRERRGGSRSPSPQSRQLPRVAPDRGHSSGSRGSSEEGPSGPPGPWAFPPAVPRSLGLLPALRLETVDPGGGGSWGPDQEAPDPNSLSPSPQGRLGLEDGGLGP", "length": 1001 }, "evidence": [ { "id": "FB:FBgn0034179", "url": "https://alliancegenome.org/gene/FB:FBgn0034179#orthology", "database": "AGR" }, { "id": "FB:FBgn0030761", "url": "https://alliancegenome.org/gene/FB:FBgn0030761#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 27, "go_terms": [ { "name": "negative regulation of D-glucose transmembrane transport", "id": "GO:0010829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010829", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "negative regulation of insulin receptor signaling pathway", "id": "GO:0046627", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046627", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "in utero embryonic development", "id": "GO:0001701", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001701", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "G protein-coupled receptor signaling pathway", "id": "GO:0007186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007186", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "cellular response to insulin stimulus", "id": "GO:0032869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032869", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "cellular response to cAMP", "id": "GO:0071320", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071320", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "protein localization to plasma membrane", "id": "GO:0072659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072659", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "positive regulation of urine volume", "id": "GO:0035810", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035810", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "cellular response to hormone stimulus", "id": "GO:0032870", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032870", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "glucose homeostasis", "id": "GO:0042593", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042593", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "negative regulation of calcium ion transport", "id": "GO:0051926", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051926", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "response to insulin", "id": "GO:0032868", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032868", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "negative regulation of single stranded viral RNA replication via double stranded DNA intermediate", "id": "GO:0045869", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045869", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "ruffle assembly", "id": "GO:0097178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097178", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "regulation of glycogen biosynthetic process", "id": "GO:0005979", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005979", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "cellular response to tumor necrosis factor", "id": "GO:0071356", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071356", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "cellular response to epidermal growth factor stimulus", "id": "GO:0071364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071364", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "id": "GO:0051898", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051898", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "negative regulation of stress fiber assembly", "id": "GO:0051497", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051497", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "phosphatidylinositol dephosphorylation", "id": "GO:0046856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046856", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "negative regulation of dephosphorylation", "id": "GO:0035305", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035305", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "negative regulation by host of viral transcription", "id": "GO:0043922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043922", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "negative regulation of protein targeting to membrane", "id": "GO:0090315", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090315", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "negative regulation of glycogen biosynthetic process", "id": "GO:0045719", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045719", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "positive regulation of renal water transport", "id": "GO:2001153", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001153", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 11, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "neuron projection", "id": "GO:0043005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043005", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "ruffle membrane", "id": "GO:0032587", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032587", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "ruffle", "id": "GO:0001726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001726", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "trans-Golgi network", "id": "GO:0005802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005802", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 8, "go_terms": [ { "name": "phosphatidylinositol phosphate 5-phosphatase activity", "id": "GO:0034595", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034595", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "vasopressin receptor activity", "id": "GO:0005000", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005000", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity", "id": "GO:0004439", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004439", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "inositol bisphosphate phosphatase activity", "id": "GO:0016312", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016312", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity", "id": "GO:0034485", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034485", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "phosphatidylinositol trisphosphate phosphatase activity", "id": "GO:0034594", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034594", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "inositol trisphosphate phosphatase activity", "id": "GO:0046030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046030", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" }, { "name": "inositol-polyphosphate 5-phosphatase activity", "id": "GO:0004445", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004445", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2Z2", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 345, "end_pos": 347, "annotation": "n_glycosylation_sequon" }, { "start_pos": 400, "end_pos": 402, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-RNO-1675949", "name": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P97573-1", "Q9JMC1-1", "Q9WVR3-1", "A0A0G2K2Z2-1" ], "evidence": [ { "id": "R-RNO-1675949", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1675949" } ] }, { "id": "R-RNO-1676177", "name": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9JMC1-1", "Q62910-1", "O55207-1", "A0A0G2K2Z2-1" ], "evidence": [ { "id": "R-RNO-1676177", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1676177" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A0G2K2Z2", "gene_name": "Inpp5k", "activity": [ { "ec_number": "3.1.3.86", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.", "evidence": [ { "id": "A0A0G2K2Z2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ] }, { "ec_number": "3.1.3.56", "activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.", "evidence": [ { "id": "A0A0G2K2Z2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ] }, { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "A0A0G2K2Z2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "A0A0G2K2Z2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ] }, { "ec_number": "3.1.3.86", "activity": "", "evidence": [ { "id": "A0A0G2K2Z2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ] }, { "ec_number": "3.1.3.56", "activity": "", "evidence": [ { "id": "A0A0G2K2Z2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K2Z2" } ] } ] }, { "uniprot_ac": "O55207", "gene_name": "Synj2", "activity": [ { "ec_number": "3.1.3.36", 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