{ "uniprot_canonical_ac": "A0A0G2K047-1", "uniprot_ac": "A0A0G2K047", "uniprot_id": "ACSS3_RAT", "mass": { "chemical_mass": 74675.0, "monoisotopic_mass": 74675.0 }, "refseq": { "ac": "NP_001401870", "name": "acyl-CoA synthetase short-chain family member 3, mitochondrial isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001401870" }, "gene_names": [ { "name": "Acss3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K047", "id": "A0A0G2K047" }, { "name": "Acss3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001401870", "id": "NP_001401870" }, { "name": "RGD1307051", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001401870", "id": "NP_001401870" } ], "protein_names": [ { "name": "Acyl-CoA synthetase short-chain family member 3, mitochondrial", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K047/entry#names_and_taxonomy", "id": "A0A0G2K047" }, { "name": "6.2.1.17", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K047/entry#names_and_taxonomy", "id": "A0A0G2K047" }, { "name": "6.2.1.1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K047/entry#names_and_taxonomy", "id": "A0A0G2K047" }, { "name": "Acetate--CoA ligase 3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K047/entry#names_and_taxonomy", "id": "A0A0G2K047" }, { "name": "Acyl-CoA synthetase short-chain family member 3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K047/entry#names_and_taxonomy", "id": "A0A0G2K047" }, { "name": "Propionate--CoA ligase", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K047/entry#names_and_taxonomy", "id": "A0A0G2K047" }, { "name": "acyl-CoA synthetase short-chain family member 3, mitochondrial isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001401870", "id": "NP_001401870" }, { "name": "acyl-CoA synthetase short-chain family member 3, mitochondrial; acetate--CoA ligase 3; propionate--CoA ligase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001401870", "id": "NP_001401870" } ], "function": [ { "annotation": "Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:28003429). Propionate is the preferred substrate but can also utilize acetate and butyrate with a much lower affinity (PubMed:28003429).", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K047", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K047#function" }, { "database": "PubMed", "id": "28003429", "url": "https://glygen.org/publication/PubMed/28003429" } ] }, { "annotation": "The results suggested that ACSS3 is a liver mitochondrial matrix enzyme with high affinity to propionic acid, and its expression level is upregulated under ketogenic conditions.", "evidence": [ { "database": "RefSeq", "id": "NP_001401870", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001401870" }, { "database": "PubMed", "id": "28003429", "url": "https://glygen.org/publication/PubMed/28003429" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K047", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K047" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "gene": [ { "name": "Acss3", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K047", "locus": { "chromosome": "7", "start_pos": 42242652, "end_pos": 42450230, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000004448", "url": "https://www.ensembl.org/id/ENSRNOG00000004448" } ] } } ], "crossref": [ { "id": "RGD:1307051", "url": "https://alliancegenome.org/gene/RGD:1307051", "database": "AGR", "categories": [ "Protein Classification" ] }, { "id": "A0A0G2K047", "url": "https://alphafold.ebi.ac.uk/entry/A0A0G2K047", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSRNOG00000004448", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000004448", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "6.2.1.17", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=6.2.1.17&UniProtAcc=A0A0G2K047", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "cd05967", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05967", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "314800", "url": "https://www.ncbi.nlm.nih.gov/gene/314800", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "A0A0G2K047", "url": "https://www.ebi.ac.uk/intact/interactors/id:A0A0G2K047*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000873", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000873", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020845", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020845", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032387", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032387", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042099", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042099", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045851", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045851", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:314800", "url": "https://www.genome.jp/dbget-bin/www_bget?rno:314800", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FIMGRTD", "url": "https://omabrowser.org/oma/group/FIMGRTD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A0G2K047", "url": "https://www.orthodb.org/?gene=A0A0G2K047", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "D3ZGU2", "url": "https://www.orthodb.org/?gene=D3ZGU2", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43347", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43347", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43347:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43347:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00501", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00501", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13193", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13193", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF16177", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF16177", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_A0A0G2K047", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:PR_A0A0G2K047", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-77111", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-77111", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001401870", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001401870", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1307051", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1307051", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "20373", "url": "https://www.rhea-db.org/rhea/20373", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "23176", "url": "https://www.rhea-db.org/rhea/23176", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "46172", "url": "https://www.rhea-db.org/rhea/46172", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A0G2K047", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K047", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2K047-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K047-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3ZGU2", "url": "https://www.uniprot.org/uniprotkb/D3ZGU2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3ZGU2-1", "url": "https://www.uniprot.org/uniprotkb/D3ZGU2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKPSWLQCRKVTGAGTLGAPLPGSPSVRGAGVARRALVAGFGGRGCRALTTSSGGGEYKTHFAASVADPERFWGKAAEQISWYKPWTKTLENRYPPSTSWFVEGMLNICYNAIDRHIENGQGDKIAIIYDSPVTDTKATISYKEVLEQVSKLAGVLVKQGVKKGDTVVIYMPMIPQAIYAMLACARIGAIHSLIFGGFASKELSTRIDHVKPKVVVTASFGIEPGRKVEYMPLLEEALRIGQHKPDRLLIYNRPNMEKVPLMSGRDLDWEEEMAKAQSHDCVPVLSEHPLYILYTSGTTGLPKGVVRPTGGYAVMLNWTMSSIYGLKPGEVWWAASDLGWVVGHSYICYGPLLHGNTTVLYEGKPVGTPDAGAYFRVLAEHGVAALFTAPTAIRAIRQQDPGAALGKQYSLTRFKTLFVAGERCDVETLEWSKKVFRVPVLDHWWQTETGSPITASCIGLGNSKTPPPGQAGKCVPGYNVMILDDNMQKLKARSLGNIVVKLPLPPGAFSGLWKNQEAFKHLYFEKFPGYYDTMDAGYMDEEGYLYVMSRVDDVINVAGHRISAGAIEESVLSHGTVTDCAVVGKEDPLKGHVPLALCVLKKDVNATEEQVLEEIVKHVRQSIGPVAAFRNAVFVKQLPKTRSGKIPRSTLSALVNGKPYKVTPTIEDPSIFGHIEEVLKQAL", "length": 683, "header": "sp|A0A0G2K047-1|ACSS3_RAT Isoform 1 of Acyl-CoA synthetase short-chain family member 3, mitochondrial OS=Rattus norvegicus OX=10116 GN=Acss3 PE=1 SV=1 CANONICAL=A0A0G2K047-1" }, "isoforms": [ { "isoform_ac": "A0A0G2K047-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K047/entry#A0A0G2K047-1", "sequence": { "sequence": "MKPSWLQCRKVTGAGTLGAPLPGSPSVRGAGVARRALVAGFGGRGCRALTTSSGGGEYKTHFAASVADPERFWGKAAEQISWYKPWTKTLENRYPPSTSWFVEGMLNICYNAIDRHIENGQGDKIAIIYDSPVTDTKATISYKEVLEQVSKLAGVLVKQGVKKGDTVVIYMPMIPQAIYAMLACARIGAIHSLIFGGFASKELSTRIDHVKPKVVVTASFGIEPGRKVEYMPLLEEALRIGQHKPDRLLIYNRPNMEKVPLMSGRDLDWEEEMAKAQSHDCVPVLSEHPLYILYTSGTTGLPKGVVRPTGGYAVMLNWTMSSIYGLKPGEVWWAASDLGWVVGHSYICYGPLLHGNTTVLYEGKPVGTPDAGAYFRVLAEHGVAALFTAPTAIRAIRQQDPGAALGKQYSLTRFKTLFVAGERCDVETLEWSKKVFRVPVLDHWWQTETGSPITASCIGLGNSKTPPPGQAGKCVPGYNVMILDDNMQKLKARSLGNIVVKLPLPPGAFSGLWKNQEAFKHLYFEKFPGYYDTMDAGYMDEEGYLYVMSRVDDVINVAGHRISAGAIEESVLSHGTVTDCAVVGKEDPLKGHVPLALCVLKKDVNATEEQVLEEIVKHVRQSIGPVAAFRNAVFVKQLPKTRSGKIPRSTLSALVNGKPYKVTPTIEDPSIFGHIEEVLKQAL", "length": 683, "header": "sp|A0A0G2K047-1|ACSS3_RAT Isoform 1 of Acyl-CoA synthetase short-chain family member 3, mitochondrial OS=Rattus norvegicus OX=10116 GN=Acss3 PE=1 SV=1 CANONICAL=A0A0G2K047-1" }, "locus": { "chromosome": "7", "start_pos": 42450143, "end_pos": 42243920, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000082141.2", "url": "https://www.ensembl.org/id/ENSRNOT00000082141.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000071300.1", "url": "https://www.ensembl.org/id/ENSRNOP00000071300.1" } ] } }, { "isoform_ac": "D3ZGU2-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K047/entry#D3ZGU2-1", "sequence": { "sequence": "MKPSWLQCRKVTGAGTLGAPLPGSPSVRGAGVARRALVAGFGGRGCRALTTSSGGGEYKTHFAASVADPERFWGKAAEQISWYKPWTKTLENRYPPSTSWFVEGMLNICYNAIDRHIENGQGDKIAIIYDSPVTDTKATISYKEVLEQVSKLAGVLVKQGVKKGDTVVIYMPMIPQAIYAMLACARIGAIHSLIFGGFASKELSTRIDHVKPKVVVTASFGIEPGRKVEYMPLLEEALRIGQHKPDRLLIYNRPNMEKVPLMSGRDLDWEEEMAKAQSHDCVPVLSEHPLYILYTSGTTGLPKGVVRPTGGYAVMLNWTMSSIYGLKPGEVWWAASDLGWVVGHSYICYGPLLHGNTTVLYEGKPVGTPDAGAYFRVLAEHGVAALFTAPTAIRAIRQQDPGAALGKQYSLTRFKTLFVAGERCDVETLEWSKKVFRVPVLDHWWQTETGSPITASCIGLGNSKTPPPGQAGKCVPGYNGSYLSYNSVMSLTSPAMKK", "length": 498, "header": "tr|D3ZGU2-1|D3ZGU2_RAT Computationally mapped isoform of Acyl-CoA synthetase short-chain family member 3, mitochondrial OS=Rattus norvegicus OX=10116 GN=Acss3 PE=3 SV=1 CANONICAL=A0A0G2K047-1" }, "locus": { "chromosome": "7", "start_pos": 42450143, "end_pos": 42269693, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000066975.2", "url": "https://www.ensembl.org/id/ENSRNOT00000066975.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000062459.1", "url": "https://www.ensembl.org/id/ENSRNOP00000062459.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Molecular cloning of rat acss3 and characterization of mammalian propionyl-CoA synthetase in the liver mitochondrial matrix.", "journal": "Journal of biochemistry", "date": "2017", "authors": "Yoshimura Y, Araki A, Maruta H, Takahashi Y, Yamashita H", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K047", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K047" }, { "database": "RefSeq", "id": "NP_001401870", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001401870" } ], "reference": [ { "type": "PubMed", "id": "28003429", "url": "https://glygen.org/publication/PubMed/28003429" } ] } ], "pathway": [ { "id": "rno:314800", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?rno:314800", "resource": "KEGG Pathway" }, { "id": "R-RNO-77111", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-77111", "resource": "Reactome", "description": "Synthesis of Ketone Bodies" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8N7TBI0-1", "protein_name": "Acyl-CoA synthetase short-chain family member 3, mitochondrial", "gene_name": "acss3", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MRLFQTTRLKHMCTAYGVKESSKTMSAVGSRCLLGLKFSCTGVYGQCYLPKVKTTFLRACEQQIHNCSTHRTHFVRGFSSKHTYEDAFGLARDKPDTFWSEAALGITWFERWTKTLDNTDLVFPKWFVGGKLNVCYNAVDRHVENGRGDQAAVIYDSPVTGTKQVITYREVQEQVSRLAGVLVKHGVKMGDLVVIYMPMVPQAMFTMLACARIGATHSLIFGGFASKELSSRIDHAKPKLLVTASFGIEPGRLVEYIPLVEKALELSTHKPHKVLIYNRPSMEKVSTRPDLTLDWEEEMSTARPHDCVSVSAHHPLYVLYTSGTTGSPKGVVRDSGGYAVMLNWTMSNVYGLAPGEVWWAASDLGWVVGHSYICYGPLLHGNTTVLYEGKPVGTPDPGAFFRVMSEHGTACMFTAPTAIRAIRQQDPQAEHGKLYPLNRLRNLFVAGERCDIETLEWAKKSFGVPVLDHWWQTESGSSITASCVGLGCSLAPPPGTAGKPVPGYNVTVIDDDMQQVKPRTLGNIVVKLPLPPGAALSLWQNHMLFKELYFTKFTGYYDTMDAGFVDEEGFLYIMARSDDVINVAGHRLSTGALEESVLLHPAVVDCAVVGLEDSLKGHVPLALCVLRNDCKESEDDLVKGLVKLVRDTIGPVAAFRKVFFVKALPKTRSGKIPRSSLANLVNQKPYKISPTIEDPEVFKDIEKMLRESVKGAGK", "length": 714 }, "evidence": [ { "id": "RGD:1307051", "url": "https://alliancegenome.org/gene/RGD:1307051#orthology", "database": "AGR" }, { "id": "FB:FBgn0039184", "url": "https://alliancegenome.org/gene/FB:FBgn0039184#orthology", "database": "AGR" }, { "id": "MGI:2685720", "url": "https://alliancegenome.org/gene/MGI:2685720#orthology", "database": "AGR" }, { "id": "HGNC:24723", "url": "https://alliancegenome.org/gene/HGNC:24723#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-060503-816", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-060503-816#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A7MB45-1", "protein_name": "Acyl-CoA synthetase short-chain family member 3, mitochondrial", "gene_name": "ACSS3", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MKPSWLQCRKVTGAGGLGGSLPASSPARGAGPARRAYVAPGPRGALGGRGCRALSSGGGEYKTHFAASVTDPERFWGKAAEQISWYKPWTKTLENRHSPSTSWFVEGMLNICYNAIDRHIENGKGDKIAIIYDSPVTNTKATITYKEVLEQVSKLAGVLVKHGVKKGDTVVIYMPMIPQAMYAMLACARIGAIHSLIFGGFASKELSTRIDHAKPKLVITASFGIEPGRKVEYVPLVEEALRIGQHKPDKVLIYNRPHTDMVPLAPGYYLDWDEELSKAQSHDCVPVLSEHPLYILYTSGTTGLPKGVVRPTGGYAVMLNWSMSSIYGLKPGEVWWAASDLGWVVGHSYICYGPLLHGNTTVLYEGKPVGTPDAGAYFRVLAEHGVAALFTAPTAIRAIRQQDPGAALGKQYSLTRFKTLFVAGERCDVETLEWSKKVFRVPVLDHWWQTETGSPITASCIGLGNSKTPPPGQAGKSVPGYNVMILDDNMQKLKARCLGNIVVKLPLPPGAFSGLWKNQEAFKHLYFEKFPGYYDTMDAGYMDEEGYVYVMSRVDDVINVAGHRISAGALEESILSLGIVADCAVVGKEDSLKGHIPLALCVLKKDINTTEEHVLEEIVKHVRQTIGPVAAFRKAVFVKQLPKTRSGKIPRSTLSALVNGKPYKVSPTIEDPGIFEHIEAMLKQAS", "length": 686 }, "evidence": [ { "id": "A0A0G2K047", "url": "https://omabrowser.org/oma/group/A0A0G2K047/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "Q14DH7-1", "protein_name": "Acyl-CoA synthetase short-chain family member 3, mitochondrial", "gene_name": "Acss3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKPSWLQCRKVTGAGTLGAPLPGSPSVRGAAVTRRALVAGFGGRGCRALTTGSGGEYKTHFAASVADPERFWGKAAEQISWYKPWTKTLESRYPPSTSWFVEGMLNICYNAIDRHIENGQGDKIAIIYDSPVTDTKATISYKEVLEQVSKLAGVLVKQGVKKGDTVVIYMPMIPQAIYTMLACARIGAIHSLIFGGFASKELSTRIDHAKPKVVVTASFGIEPGRKVEYIPLLEEALRIGQHRPDRVLIYSRPNMEKVPLMSGRDLDWEEEMAKAQSHDCVPVLSEHPLYILYTSGTTGLPKGVVRPTGGYAVMLNWTMSSIYGLKPGEVWWAASDLGWVVGHSYICYGPLLHGNTTVLYEGKPVGTPDAGAYFRVLAEHGVAALFTAPTAIRAIRQQDPGAALGKQYSLTRFKTLFVAGERCDVETLEWSKKVFRVPVLDHWWQTETGSPITASCIGLGNSKTPPPGQAGKCVPGYNVMILDDNMQKLKARSLGNIVVKLPLPPGAFSGLWKNQEAFKHLYFEKFPGYYDTMDAGYMDEEGYLYVMSRVDDVINVAGHRISAGAIEESVLSHGTVADCAVVGKEDPLKGHVPLALCVLKKDVNASEEQVLEEIVKHVRQSIGPVAAFRNAVFVKQLPKTRSGKIPRSTLSALVNGKPYKVTPTIEDPSIFGHIEEVLKQAV", "length": 682 }, "evidence": [ { "id": "RGD:1307051", "url": "https://alliancegenome.org/gene/RGD:1307051#orthology", "database": "AGR" }, { "id": "FB:FBgn0039184", "url": "https://alliancegenome.org/gene/FB:FBgn0039184#orthology", "database": "AGR" }, { "id": "MGI:2685720", "url": "https://alliancegenome.org/gene/MGI:2685720#orthology", "database": "AGR" }, { "id": "HGNC:24723", "url": "https://alliancegenome.org/gene/HGNC:24723#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-060503-816", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-060503-816#orthology", "database": "AGR" }, { "id": "A0A0G2K047", "url": "https://omabrowser.org/oma/group/A0A0G2K047/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q554Z5-1", "protein_name": "Acyl-CoA synthetase short-chain family member B, mitochondrial", "gene_name": "aslB", "tax_id": 44689, "organism": "Dictyostelium discoideum", "sequence": { "sequence": "MFSNGLSKLIKSKIASTSIITTKNNYSISKLSFSSTSILLNKKYKLSEPFNYEQDCEYALKEPIQFWDEVASKYVHWNKRYEKVYSGDEYNPEWFKGGVLNACYNALDVHAKDPITKNRIAIIHETPSKNNTNKLTYGELWDEVCIFARGLHNLGVEKGDRVVIYMPMINQALIAMLACARLGATHSVVFGGFASPQLAQRIEHFKPKVVISANFGVEGHKINCYTPLLSKALELSSHKPNHTIVYNRLDVKLDAGEVLPPRVEGSLDWSELIKNIAPYRDYALVDSTHPLYILYTSGTTGMPKGVVRDTGGYSVALNYSIRNCYGMKSGDTFFAGSDVGWVVGHTLSVYGPLMVGLTSIIFEGKPTVPDASTYWKLIEKHRVNALFSAPTAIRAIHRDDADGKLASKCDLSSLRSIWLGGERLDSSTFNFLRNITNNKPILDNYWNTESGSPLITNPSCQVPIKANATGKPMPGYQFHVLSPTSERLGADKIGEVCIKLPVAPGFTNTLYLNPEGYKNAYLNEYPGYLRTADSGYYDENGYYHIISRVDDIINVSGHRLSTGSIEEILVKHPKIVECAVIGVHDELKGEIPFGLVVLKPQYKDCAEEVENELIKEVRENIGPVATFKKVLSVNRLPKTRSGKILRNILRKMYNKEEYTVPPTIEDMEVLKEIDIEFEKYKLSHPPKK", "length": 688 }, "evidence": [ { "id": "A0A0G2K047", "url": "https://omabrowser.org/oma/group/A0A0G2K047/", "database": "OMA" } ], "glygen_name": "Cellular slime mold", "common_name": "Social amoeba" }, { "uniprot_canonical_ac": "Q9H6R3-1", "protein_name": "Acyl-CoA synthetase short-chain family member 3, mitochondrial", "gene_name": "ACSS3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKPSWLQCRKVTSAGGLGGPLPGSSPARGAGAALRALVVPGPRGGLGGRGCRALSSGSGSEYKTHFAASVTDPERFWGKAAEQISWYKPWTKTLENKHSPSTRWFVEGMLNICYNAVDRHIENGKGDKIAIIYDSPVTNTKATFTYKEVLEQVSKLAGVLVKHGIKKGDTVVIYMPMIPQAMYTMLACARIGAIHSLIFGGFASKELSSRIDHVKPKVVVTASFGIEPGRRVEYVPLVEEALKIGQHKPDKILIYNRPNMEAVPLAPGRDLDWDEEMAKAQSHDCVPVLSEHPLYILYTSGTTGLPKGVIRPTGGYAVMLHWSMSSIYGLQPGEVWWAASDLGWVVGHSYICYGPLLHGNTTVLYEGKPVGTPDAGAYFRVLAEHGVAALFTAPTAIRAIRQQDPGAALGKQYSLTRFKTLFVAGERCDVETLEWSKNVFRVPVLDHWWQTETGSPITASCVGLGNSKTPPPGQAGKSVPGYNVMILDDNMQKLKARCLGNIVVKLPLPPGAFSGLWKNQEAFKHLYFEKFPGYYDTMDAGYMDEEGYLYVMSRVDDVINVAGHRISAGAIEESILSHGTVADCAVVGKEDPLKGHVPLALCVLRKDINATEEQVLEEIVKHVRQNIGPVAAFRNAVFVKQLPKTRSGKIPRSALSAIVNGKPYKITSTIEDPSIFGHVEEMLKQA", "length": 686 }, "evidence": [ { "id": "RGD:1307051", "url": "https://alliancegenome.org/gene/RGD:1307051#orthology", "database": "AGR" }, { "id": "FB:FBgn0039184", "url": "https://alliancegenome.org/gene/FB:FBgn0039184#orthology", "database": "AGR" }, { "id": "MGI:2685720", "url": "https://alliancegenome.org/gene/MGI:2685720#orthology", "database": "AGR" }, { "id": "HGNC:24723", "url": "https://alliancegenome.org/gene/HGNC:24723#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-060503-816", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-060503-816#orthology", "database": "AGR" }, { "id": "A0A0G2K047", "url": "https://omabrowser.org/oma/group/A0A0G2K047/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VC92-1", "protein_name": "Acyl-CoA synthetase short-chain family member 3, mitochondrial", "gene_name": "Dmel\\CG6432", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MEPGPSAVNYEGSESVCGMPVEAHDPLYLKAYRQSVQNPAAFWEEQGNLLDWDRPWEKVLDNSNPPFTKWYVGGYLNACYNSIDRHILAGRGSNVALIHDSPLTGTLRRVTYQELYDQIVLLAGGLAKLGVVKGDRVVIYMPLIPETIIAMLAIVRLGAIHSVVFGGFAARELCSRIEHVEPKLVIASNVGVEPGKVVPYLDILHSAISMSRWRPPQRNIIFRRDNVSPDTTKLDPLTDVLWSDILKMAEGERPIACVPIEANDPLYILYTSGTTDKPKGVLRTIGGHLVALVYTLRTLYGINPGHTWWAASDMGWVVGHSYICYGPLCLGATSVMYEGKPDRTPDPGQYFRIIDQYQVRSIFSVPTSFRVIRRADPDISYGRQYSMKSLRAIFIAGEHCDYETKSWIEKTFKVPVLNHWWQTETGSAVTATCLGFQQNLSPPTYSTGLPLMGYDVKILKADGSEAQTSELGRIALKLPLPPGNMATLYKNEELFRTLYFQKFPGYYDTMDAGYKDERGYIFVTARDDDVINVAGHRLSTSSLEDAVLRHPDVVDVAVFGVPEATKGQVPLCLYIPVENCKKTDAKLSTEIIKLIRDVVGPIAAFRLVTSVNNLPRTRSGKTMRKAMADFARNERVVLPATIDDASVFIEIRRALNQLGYAMTAPDPIVAKLLD", "length": 674 }, "evidence": [ { "id": "RGD:1307051", "url": "https://alliancegenome.org/gene/RGD:1307051#orthology", "database": "AGR" }, { "id": "FB:FBgn0039184", "url": "https://alliancegenome.org/gene/FB:FBgn0039184#orthology", "database": "AGR" }, { "id": "MGI:2685720", "url": "https://alliancegenome.org/gene/MGI:2685720#orthology", "database": "AGR" }, { "id": "HGNC:24723", "url": "https://alliancegenome.org/gene/HGNC:24723#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-060503-816", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-060503-816#orthology", "database": "AGR" }, { "id": "A0A0G2K047", "url": "https://omabrowser.org/oma/group/A0A0G2K047/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K047", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K047" } ], "pmid": "" }, { "name": "acetate-CoA ligase activity", "id": "GO:0003987", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003987", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K047", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K047" } ], "pmid": "" }, { "name": "propionate-CoA ligase activity", "id": "GO:0050218", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050218", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K047", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K047" } ], "pmid": "" }, { "name": "medium-chain fatty acid-CoA ligase activity", "id": "GO:0031956", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031956", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K047", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K047" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrial matrix", "id": "GO:0005759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005759", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K047", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K047" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "lipid metabolic process", "id": "GO:0006629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006629", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K047", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K047" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 317, "end_pos": 319, "annotation": "n_glycosylation_sequon" }, { "start_pos": 356, "end_pos": 358, "annotation": "n_glycosylation_sequon" }, { "start_pos": 605, "end_pos": 607, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "20373", "name": "", "equation": "propanoate + ATP + CoA = propanoyl-CoA + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6SKG1-1", "A0A0G2K047-1", "A0A8I6GJ11-1", "D3ZZN3-1" ], "evidence": [ { "id": "20373", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/20373" } ] }, { "id": "23176", "name": "", "equation": "acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3ZZN3-1", "A0A0G2K047-1", "A0A8I6GJ11-1" ], "evidence": [ { "id": "23176", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/23176" } ] }, { "id": "46172", "name": "", "equation": "butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O70490-1", "Q6SKG1-1", "A0A0G2K047-1" ], "evidence": [ { "id": "46172", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46172" } ] }, { "id": "R-RNO-8875071", "name": "ACSS3 ligates CoA to CH3COO-", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [ "R-ALL-113539" ], "output_participant_list": [], "enzyme_list": [ "A0A0G2K047-1" ], "evidence": [ { "id": "R-RNO-8875071", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8875071" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-113539", "participant_name": "CH3COO- [mitochondrial matrix]", "crossref": [ { "id": "30089", "database": "ChEBI", "url": "" }, { "id": "C00033", "database": "COMPOUND", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A0G2K047", "gene_name": "Acss3", "activity": [ { "ec_number": "6.2.1.1", "activity": "acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "A0A0G2K047", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K047" } ] }, { "ec_number": "6.2.1.17", "activity": "propanoate + ATP + CoA = propanoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "A0A0G2K047", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K047" } ] }, { "ec_number": "6.2.1.1", "activity": "", "evidence": [ { "id": "A0A0G2K047", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K047" } ] }, { "ec_number": "6.2.1.17", "activity": "", "evidence": [ { "id": "A0A0G2K047", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2K047" } ] } ] }, { "uniprot_ac": "A0A8I6GJ11", "gene_name": "Acss2", "activity": [ { "ec_number": "6.2.1.1", "activity": "acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "A0A8I6GJ11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GJ11" } ] }, { "ec_number": "6.2.1.17", "activity": "propanoate + ATP + CoA = propanoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "A0A8I6GJ11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GJ11" } ] }, { "ec_number": "6.2.1.17", "activity": "", "evidence": [ { "id": "A0A8I6GJ11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GJ11" } ] }, { "ec_number": "6.2.1.1", "activity": "", "evidence": [ { "id": "A0A8I6GJ11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GJ11" } ] } ] }, { "uniprot_ac": "D3ZZN3", "gene_name": "Acss1", "activity": [ { "ec_number": "6.2.1.1", "activity": "acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "D3ZZN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZZN3" } ] }, { "ec_number": "6.2.1.1", "activity": "", "evidence": [ { "id": "D3ZZN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZZN3" } ] } ] }, { "uniprot_ac": "O70490", "gene_name": "Acsm2", "activity": [ { "ec_number": "6.2.1.2", "activity": "a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O70490", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O70490" } ] }, { "ec_number": "6.2.1.2", "activity": "", "evidence": [ { "id": "O70490", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O70490" } ] }, { "ec_number": "6.2.1.25", "activity": "benzoate + ATP + CoA = benzoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O70490", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O70490" } ] } ] }, { "uniprot_ac": "Q6SKG1", "gene_name": "Acsm3", "activity": [ { "ec_number": "6.2.1.2", "activity": "a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q6SKG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6SKG1" } ] }, { "ec_number": "6.2.1.2", "activity": "", "evidence": [ { "id": "Q6SKG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6SKG1" } ] }, { "ec_number": "6.2.1.17", "activity": "propanoate + ATP + CoA = propanoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q6SKG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q6SKG1" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A0G2K047-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 683, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A0G2K047-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A0G2K047" } ], "synthesized_glycans": [], "enzyme_annotation": [ { "ec_number": "6.2.1.1", "ec_name": "acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "6.2.1.1", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.1" }, { "id": "6.2.1.1", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=6.2.1.1" } ] }, { "ec_number": "6.2.1.17", "ec_name": "propanoate + ATP + CoA = propanoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "6.2.1.17", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.17" }, { "id": "6.2.1.17", "database": "BRENDA Enzymes", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=6.2.1.17" } ] } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.agr", "label": "AGR Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 317, "end_pos": 319 }, { "start_pos": 356, "end_pos": 358 }, { "start_pos": 605, "end_pos": 607 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }