{ "uniprot_canonical_ac": "A0A0G2JWS1-1", "uniprot_ac": "A0A0G2JWS1", "uniprot_id": "A0A0G2JWS1_RAT", "mass": { "chemical_mass": 93166.0, "monoisotopic_mass": 93166.0 }, "refseq": { "ac": "XP_063141814", "name": "leucine-rich repeat and guanylate kinase domain-containing protein isoform X5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_063141814" }, "gene_names": [ { "name": "Lrguk", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JWS1", "id": "A0A0G2JWS1" }, { "name": "Lrguk", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_063141814", "id": "XP_063141814" }, { "name": "RGD1308226", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_063141814", "id": "XP_063141814" } ], "protein_names": [ { "name": "Leucine-rich repeat and guanylate kinase domain-containing protein", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JWS1/entry#names_and_taxonomy", "id": "A0A0G2JWS1" }, { "name": "leucine-rich repeat and guanylate kinase domain-containing protein isoform X5", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_063141814", "id": "XP_063141814" } ], "function": [ { "annotation": "Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis.", "evidence": [ { "database": "UniProtKB", "id": "D4A3R3", "url": "https://www.uniprot.org/uniprotkb/D4A3R3#function" }, { "database": "UniProtKB", "id": "ARBA00054148", "url": "https://www.uniprot.org/uniprotkb/ARBA00054148#function" }, { "database": "UniProtKB", "id": "A0A8I6GHE9", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GHE9#function" }, { "database": "UniProtKB", "id": "A0A0G2JWS1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JWS1#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JWS1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JWS1" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "gene": [ { "name": "Lrguk", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JWS1", "locus": { "chromosome": "4", "start_pos": 62770319, "end_pos": 62647264, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000008775", "url": "https://www.ensembl.org/id/ENSRNOG00000008775" } ] } } ], "crossref": [ { "id": "RGD:1308226", "url": "https://alliancegenome.org/gene/RGD:1308226", "database": "AGR", "categories": [ "Protein Classification" ] }, { "id": "A0A0G2JWS1", "url": "https://alphafold.ebi.ac.uk/entry/A0A0G2JWS1", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSRNOG00000008775", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000008775", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00071", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00071", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "296968", "url": "https://www.ncbi.nlm.nih.gov/gene/296968", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008144", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008144", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008145", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008145", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "CNQISEM", "url": "https://omabrowser.org/oma/group/CNQISEM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A8I6GHE9", "url": "https://www.orthodb.org/?gene=A0A8I6GHE9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23117", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23117", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23117:SF18", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23117:SF18", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00560", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00560", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00625", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00625", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13516", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13516", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF14580", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF14580", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "XP_063141814", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_063141814", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1308226", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1308226", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A0G2JWS1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JWS1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2JWS1-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JWS1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6GHE9", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GHE9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6GHE9-1", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GHE9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D4A3R3", "url": "https://www.uniprot.org/uniprotkb/D4A3R3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D4A3R3-1", "url": "https://www.uniprot.org/uniprotkb/D4A3R3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MATFEGSPSRWKGTRFQRSLGASRAVAQAILSLTDKEPQKRWPTFPMGLRSKGTFRSASSYLLHQLIHRSHEAEVEQEEQQEEGESEESEESEMQNLEDEYDGVLREENVADALDGLGWSGRGTEQVYRNLNLSHCELIDVSILSGYVHLQKLNLSGNRIEDLSCVSCMPYLLELNASQNRLTTFFNFKPPQNLKKVDFSSNQISEMYDLSAYHTLTQLILDNNEIEEITGLEKCISLTHLSLAGNRITTIKGLGTLPIKVLSVSNNQIETITGLEELKALQNLDLSHNQISSLHGLENHDLLEVINLEDNKIKELSEIEYIENLPILRVLNLLRNPIQTKPEYWFFVIFMLLRLTELDQQKIKVEEKVYAVNKYDPPPEVVAAQDHMTHVVNSMSQPQRIFDSTLPSLDAPYPMLILTGPEACGKRELAHRLCRQFSTYFRYGACHTTRPPYFGEGDRVDYHFVSQEVFDEMLSMGKFILTFNYGNHNYGLNRDTVEGIARDGLASCIHMELEGIRSLKYSYFEPRYILVVPMDKEKYEGYLRRKGLFSRAEIEIAVSRVDLYVKVNRKFPGYFDAVINADDLDIAYQKLSELIREYLGLTETAKKGLAPTADTKTSYVKSEDYSRKSSTVELSDSTDRNYFTKLWAKLSSKKSPVERESLQRQHETARQALMGKTPRDHTLLFQRGPVPIPTVSGHQYFATIDELQKTFELCEDHVKAPFGPYPETSKDSNISQRYSTLFQTCPWFKELPFQLPEGGVSSRPGSAGSDLEVDGALKGGKHGGSQSCYSQRHTGTLKGCSAQSCHSRRNNGPRVSQRTQ", "length": 820, "header": "tr|A0A0G2JWS1-1|A0A0G2JWS1_RAT Isoform 1 of Leucine-rich repeat and guanylate kinase domain-containing protein OS=Rattus norvegicus OX=10116 GN=Lrguk PE=4 SV=1 CANONICAL=A0A0G2JWS1-1" }, "isoforms": [ { "isoform_ac": "A0A0G2JWS1-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JWS1/entry#A0A0G2JWS1-1", "sequence": { "sequence": "MATFEGSPSRWKGTRFQRSLGASRAVAQAILSLTDKEPQKRWPTFPMGLRSKGTFRSASSYLLHQLIHRSHEAEVEQEEQQEEGESEESEESEMQNLEDEYDGVLREENVADALDGLGWSGRGTEQVYRNLNLSHCELIDVSILSGYVHLQKLNLSGNRIEDLSCVSCMPYLLELNASQNRLTTFFNFKPPQNLKKVDFSSNQISEMYDLSAYHTLTQLILDNNEIEEITGLEKCISLTHLSLAGNRITTIKGLGTLPIKVLSVSNNQIETITGLEELKALQNLDLSHNQISSLHGLENHDLLEVINLEDNKIKELSEIEYIENLPILRVLNLLRNPIQTKPEYWFFVIFMLLRLTELDQQKIKVEEKVYAVNKYDPPPEVVAAQDHMTHVVNSMSQPQRIFDSTLPSLDAPYPMLILTGPEACGKRELAHRLCRQFSTYFRYGACHTTRPPYFGEGDRVDYHFVSQEVFDEMLSMGKFILTFNYGNHNYGLNRDTVEGIARDGLASCIHMELEGIRSLKYSYFEPRYILVVPMDKEKYEGYLRRKGLFSRAEIEIAVSRVDLYVKVNRKFPGYFDAVINADDLDIAYQKLSELIREYLGLTETAKKGLAPTADTKTSYVKSEDYSRKSSTVELSDSTDRNYFTKLWAKLSSKKSPVERESLQRQHETARQALMGKTPRDHTLLFQRGPVPIPTVSGHQYFATIDELQKTFELCEDHVKAPFGPYPETSKDSNISQRYSTLFQTCPWFKELPFQLPEGGVSSRPGSAGSDLEVDGALKGGKHGGSQSCYSQRHTGTLKGCSAQSCHSRRNNGPRVSQRTQ", "length": 820, "header": "tr|A0A0G2JWS1-1|A0A0G2JWS1_RAT Isoform 1 of Leucine-rich repeat and guanylate kinase domain-containing protein OS=Rattus norvegicus OX=10116 GN=Lrguk PE=4 SV=1 CANONICAL=A0A0G2JWS1-1" }, "locus": { "chromosome": "4", "start_pos": 62770243, "end_pos": 62647279, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000082175.2", "url": "https://www.ensembl.org/id/ENSRNOT00000082175.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000069992.1", "url": "https://www.ensembl.org/id/ENSRNOP00000069992.1" } ] } }, { "isoform_ac": "A0A8I6GHE9-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JWS1/entry#A0A8I6GHE9-1", "sequence": { "sequence": "MATFEGSPSRWKGTRFQRSLGASRAVAQAILSLTDKEPQKRWPTFPMGLRSKGTFRSASSYLLHQLIHRSHEAEVEQEEQQEEGESEESEESEMQNLEDEYDGVLREENVADALDGLGWSGRGTEQVYRNLNLSHCELIDVSILSGYVHLQKLNLSGNRIEDLSCVSCMPYLLELNASQNRLTTFFNFKPPQNLKKVDFSSNQISEMYDLSAYHTLTQLILDNNEIEEITGLEKCISLTHLSLAGNRITTIKGLGTLPIKVLSVSNNQIETITGLEELKALQNLDLSHNQISSLHGLENHDLLEVINLEDNKIKELSEIEYIENLPILRVLNLLRNPIQTKPEYWFFVIFMLLRLTELDQQKIKVEEKVYAVNKYDPPPEVVAAQDHMTHVVNSMSQPQRIFDSTLPSLDAPYPMLILTGPEACGKRELAHRLCRQFSTYFRYGACHTTRPPYFGEGDRVDYHFVSQEVFDEMLSMGKFILTFNYGNHNYGLNRDTVEGIARDGLASCIHMELEGIRSLKYSYFEPRYILVVPMDKEKYEGYLRRKGLFSRAEIEIAVSRVDLYVKVNRKFPGYFDAVINADDLDIAYQKLSELIREYLGLTETAKKGLAPTAGASSSKKTVSGVPAHLVPSPRRLARLQADGQKTEAFLEVQPHAMIPENQNPTLPQSQDLTEEGEAPKKEASPSHLDLPQQTQDISPKVKEEDGQPANLPPKITTETEGPEDEPVPPVLEAGQSSTMASQEPPQHPAPAPPLSPQLDQDKESGETKVTPNNPALSEPAQGPDPASVSPQRVQDEGAESANLASSSSTHNLPEDPSHAEIEKPTVGSQPSLKEETPKAEVMRASTPYPEIPPPQDSSTKVREQPVALLPRSRLAPTRLPQPQTLAPLQSRRPTPKLLSPSREEALGTSSEQTPNPSPRSLPTQDGDPSKLPPISPPQSKPPQNPSPHAVHSPQQAQVEKGSEVKLPLISPPVQEQALQHTPKPPQEEEAPTVRLPNIPAPSTEPHLPQNTEPRPASKPARERKTPKVGRASSKKVLDLQATPHSQELTKQKGARKKTLTQRETAKELPHPKKMPIGNSQTAQQPESHSRPTPRNESDALDFRSSPGHTEPVSADPQNREKNRKAHNPRKKAQTNPTPKDASQSTRTSPNGEMSEGLTQGNETALSEDQPTREGQPPQATDQSAQDIAVPSQLRAKESQAQRNTRETRQSYAQRHSILVSKQQSKEKRTRKNGGVPQDRSPAAPQNEVSQEDPGSQTGRLRARGSQSIKV", "length": 1270, "header": "tr|A0A8I6GHE9-1|A0A8I6GHE9_RAT Computationally mapped isoform of Leucine-rich repeat and guanylate kinase domain-containing protein OS=Rattus norvegicus OX=10116 GN=Lrguk PE=4 SV=1 CANONICAL=A0A0G2JWS1-1" }, "locus": { "chromosome": "4", "start_pos": 62720373, "end_pos": 62647279, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000108064.1", "url": "https://www.ensembl.org/id/ENSRNOT00000108064.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000088777.1", "url": "https://www.ensembl.org/id/ENSRNOP00000088777.1" } ] } }, { "isoform_ac": "D4A3R3-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JWS1/entry#D4A3R3-1", "sequence": { "sequence": "MGLRSKGTFRSASSYLLHQLIHRSHEAEVEQEEQQEEGESEESEESEMQNLEDEYDGVLREENVADALDGLGWSGRGTEQVYRNLNLSHCELIDVSILSGYVHLQKLNLSGNRIEDLSCVSCMPYLLELNASQNRLTTFFNFKPPQNLKQKVDFSSNQISEMYDLSAYHTLTQLILDNNEIEEITGLEKCISLTHLSLAGNRITTIKGLGTLPIKVLSVSNNQIETITGLEELKALQNLDLSHNQISSLHGLENHDLLEVINLEDNKIKELSEIEYIENLPILRVLNLLRNPIQTKPEYWFFVIFMLLRLTELDQQKIKVEEKVYAVNKYDPPPEVVAAQDHMTHVVNSMSQPQRIFDSTLPSLDAPYPMLILTGPEACGKRELAHRLCRQFSTYFRYGACHTTRPPYFGEGDRVDYHFVSQEVFDEMLSMGKFILTFNYGNHNYGLNRDTVEGIARDGLASCIHMELEGIRSLKYSYFEPRYILVVPMDKEKYEGYLRRKGLFSRAEIEIAVSRVDLYVKVNRKFPGYFDAVINADDLDIAYQKLSELIREYLGLTETAKKGLAPTADTKTSYVKSEDYSRKSSTVELSDSTDRNYFTKLWAKLSSKKSPVERESLQRQHETARQALMGKTPRDHTLLFQRGPVPIPTVSGHQYFATIDELQKTFELCEDHVKAPFGPYPETSKDSNISQRYSTLFQTCPWFKELPFQLPEGGVSSRPGSAGSDLEVDGALKALRVTSSMQDKVAQHKRMSALAITYPGSNTKPTLPPIPHGRR", "length": 775, "header": "tr|D4A3R3-1|D4A3R3_RAT Computationally mapped isoform of Leucine-rich repeat and guanylate kinase domain-containing protein OS=Rattus norvegicus OX=10116 GN=Lrguk PE=4 SV=3 CANONICAL=A0A0G2JWS1-1" }, "locus": { "chromosome": "4", "start_pos": 62753924, "end_pos": 62647417, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000011692.7", "url": "https://www.ensembl.org/id/ENSRNOT00000011692.7" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000011692.7", "url": "https://www.ensembl.org/id/ENSRNOP00000011692.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0AB32TU23-1", "protein_name": "Leucine-rich repeat and guanylate kinase domain-containing protein", "gene_name": "lrguk", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSVRSGSVSDRTPAHLPVSLCAISGFYRMTFYWHLNRISDCVWPQGRDLKNVSILCNYIYLQKLELPYNKIKDLSCVSHMPYLITLDASHNQLTDFFGFQPPKNLKEVNFSHNQMTAMKDLSAYSSLTKLILDHNSFSVIRGLEKCKRLSHLSLAHNNISRIRGLDHLPLRELCLAGNMINKIENLQTLHNLQVLDLSCNRIQSLTGLQNLRFLGTVNLESNLITEIKEAAHLHDLILLREINLLKNPVQDHDDYRIAVIFLLQHLILLDKQTVTAEEKVAAVNKYDPPLEVVAARDHMTHLVYQLMQPQVIFDSTLPSLDAPYPMLVLTGPQACGKRELAHKLCQEFSDYFAYGACHTTRGPYFGEEDGLDYHFVTEEEFHNMIQMGQFIQTMQYGGHWYGLSRESIERVAREGLACCVHMELEGVFSLKNSYFEPRYVLLIPSVVDNYVLFLKARGFYSNAQMETAVSRIDLYARINRERPGFFDSIIPCDDRAEAYRSLKQLVKEYLGLEEHSGGGDSSSITPDNTSTNTTGELPAASATESTDLMDSYSRNYQKKIQANMTPQRTEMASNHRRLQQIREALSGKSPGAYAELFQRSVPAAPSSLASQSHPPAGPSSSPVRPAGLSAPNLSEDSSSEESRASSGLSMRSSAGVFSAESPARGSDAGSGPNIEPLDISMLGQDRDSLRGLTPDAPRPASDRVSPTHPSSPGRPGANVKPVLPPIPSGRKTNDSGSKQ", "length": 739 }, "evidence": [ { "id": "MGI:1921604", "url": "https://alliancegenome.org/gene/MGI:1921604#orthology", "database": "AGR" }, { "id": "HGNC:21964", "url": "https://alliancegenome.org/gene/HGNC:21964#orthology", "database": "AGR" }, { "id": "RGD:1308226", "url": "https://alliancegenome.org/gene/RGD:1308226#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-050419-232", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-050419-232#orthology", "database": "AGR" }, { "id": "A0A0G2JWS1", "url": "https://omabrowser.org/oma/group/A0A0G2JWS1/", "database": "OMA" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "E1BAV1-1", "protein_name": "Leucine-rich repeat and guanylate kinase domain-containing protein", "gene_name": "LRGUK", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MATSGREPKFPKPSSLQGGKSISRTGAQSKVLHSEKDRHSCWSPFPMGQRPKNTLCKASSYLLQHLIHRYQESDVDRDYYDLEEGEGEGEVESEESSESEMLNFEGGFDGVLREEVVAEKLYQLGRSGSGTEQVYLSLTLSDLDLTDVSILCGYVHLQKLDLSVNKIEDLSCVSCMPYLLELNASQNHLKTFFNFKPPKKLKKVDFSYNQISEMCSLSAYESLTKLILDSNEITEISGLELCSSLTYLSLANNKITTINGLGMLPIKILCLSNNQIEKMTGLDDLRVLQILDLSQNQISSLQGLEGHDFLEVINLEDNKVAELGEIEYIENLPLLRVLNLLRNPVREKPDYWSFVIFMLLRLTELDQKKIKVDEKISAVNKYNPPPEVVAAQDHMTHVVNSVMQPQRIFDSTLPSLDAPYPMLVLAGPQACGKRELAHRLCRQFSTYFRYGACHTTRLPYFGEGDRVDYHFTSQEVFDEMQNMGKFILTYNYGNHKYGLSRDTIEGIARDGLASCVHMEIEGVRSLKHCYFEPRYILVVPMDKQKYEGYLRRKGLFSRVEIEFAVSRVDLYIKINQKYPGYFDAVINADDLDVAYQKLSQLIREYLGFSEVTAKSLAPTTDTKKPQLKPEKISRKLRVSNEFESLDFADRNYFVKLWARLSGKKTPVERESLARQYETARQTLMGNTPPQHTFLFQRGLVPAPIINSLRYFTALELKKSFELYGDYFKAPFGPSEKSVMDSSDSMQYPELLHSCPWPKDLPFQPLEDRIYSQPGSIIGDTEDHALKALYKQAFPHGKGSLQHRRHMVSAISRPGSNIKPTLPPIPQGRK", "length": 829 }, "evidence": [ { "id": "A0A0G2JWS1", "url": "https://omabrowser.org/oma/group/A0A0G2JWS1/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "Q96M69-1", "protein_name": "Leucine-rich repeat and guanylate kinase domain-containing protein", "gene_name": "LRGUK", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MATSERALLRTRAASLLRGLGRSRTGARSLQFRAEKERQPCWSFPMGQKTKGSSNIASSYLLQQLMHRYQELDSDGDEDQGEGEAGSEESSESEMLNLEEEFDGVLREEAVAKALHHLGRSGSGTEQVYLNLTLSGCNLIDVSILCGYVHLQKLDLSANKIEDLSCVSCMPYLLELNASQNNLTTFFNFKPPKNLKKADFSHNQISEICDLSAYHALTKLILDGNEIEEISGLEMCNNLIHLSLANNKITTINGLNKLPIKILCLSNNQIEMITGLEDLKALQNLDLSHNQISSLQGLENHDLLEVINLEDNKIAELREIEYIKNLPILRVLNLLENPIQEKSEYWFFVIFMLLRLTELDQKKIKVEEKVSAVNKYDPPPEVVAAQDHLTHVVNSVMQPQRIFDSTLPSLDAPYPMLILAGPEACGKRELAHRLCRQFSTYFRYGACHTTRPPYFGEGDRVDYHFISQDVFDEMVNMGKFILTFSYGNHKYGLNRDTVEGIARDGLASCIHMEIEGVRSLKYSYFEPRYILVVPMNKEKYEGYLRRKGLFSRAEIEFAVSRVDLYIKINQNFPGYFDEVINADDLDVAYQKLSQLIREYLGLTEEPAKSLATTADVKTSHLKPEAHPTKYISSNMGDFLHSTDRNYLIKFWAKLSAKKTPAERDSIHRQHEAARQALMGRIRPDHTLLFQRGPVPAPLTSGLHYYTTLEELWKSFDLCEDYFKPPFGPYPEKSGKDSLVSMKCSLFRFCPWSKELPFQPPEGSISSHLGSGASDSETEETRKALPIQSFSHEKESHQHRQHSVPVISRPGSNVKPTLPPIPQGRR", "length": 825 }, "evidence": [ { "id": "MGI:1921604", "url": "https://alliancegenome.org/gene/MGI:1921604#orthology", "database": "AGR" }, { "id": "HGNC:21964", "url": "https://alliancegenome.org/gene/HGNC:21964#orthology", "database": "AGR" }, { "id": "RGD:1308226", "url": "https://alliancegenome.org/gene/RGD:1308226#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-050419-232", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-050419-232#orthology", "database": "AGR" }, { "id": "A0A0G2JWS1", "url": "https://omabrowser.org/oma/group/A0A0G2JWS1/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9D5S7-1", "protein_name": "Leucine-rich repeat and guanylate kinase domain-containing protein", "gene_name": "Lrguk", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAFERNPSRWKGTRFRRGLGASRIAAQAILSLTEKQSQGRWPSFPLGLKSKGTFRSASSYLLHQLIHRSHEAEAEQEEKQQEDGESEESEESEMQNLEDKYDGILREETVAEAITGLGWSGRGTEQVYLNLNLSHCELVDISILCGYVHLQKLNLSGNRIEDLSCVSCMPYLLELNASQNKLTTFFNFKPPQNLKKVDFSSNLISEMYDLSAYHTLTQLILDNNEIEEITGLENCISLTHLSLAGNKITTIKGLGTLPIKVLSLSNNMIETITGLEELKALQNLDLSHNQISSLQGLENHDLLEVINLEDNKIKELSEIEYIENLPILRVLNLLRNPIQTKPEYWFFVIYMLLRLTELDQQKIKVEEKVFAVNKYDPPPEVVAVQDHMTHVVNSMSQPQRIWDSTLPSLDAPYPMLILTGPAACGKRELAHRLCRQFSTYFRYGACHTTRPPYFGEGDRVDYHFISQEVFDEMLNMGKFILTFNYGNHNYGLNRDTIEGIARDGLASCIHMELEGVRSLKYSYFEPRYILVVPMDKEKYEGYLRRKGLFSRAEIEIAVSRVDLYVKVNQKYPGYFDAVINADDMDIAYQKLSELIREYLGLTETAAKTLAPTADTKTSYLKCEDYSRKSSTVEFLDSTDRNYFTKLWAKLSSKKSPVERESLHRQHEAARQALMGKTPRDHTLLFQRGPVPIPTVSGQQYFATIDELQKTFELSDDLFKTPSGTYPETSKDSNISKRYSTYFHTCPWSKELPFQLPEGGISSRPGSAGSDEVDGALKALRVASSMQEKVAQHKRLSAITIMDPGSNTKPTLPPIPHGRR", "length": 820 }, "evidence": [ { "id": "MGI:1921604", "url": "https://alliancegenome.org/gene/MGI:1921604#orthology", "database": "AGR" }, { "id": "HGNC:21964", "url": "https://alliancegenome.org/gene/HGNC:21964#orthology", "database": "AGR" }, { "id": "RGD:1308226", "url": "https://alliancegenome.org/gene/RGD:1308226#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-050419-232", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-050419-232#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "guanylate kinase activity", "id": "GO:0004385", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004385", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JWS1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JWS1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JWS1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JWS1" } ], "pmid": "" }, { "name": "acrosomal vesicle", "id": "GO:0001669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001669", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JWS1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JWS1" } ], "pmid": "" }, { "name": "manchette", "id": "GO:0002177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002177", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JWS1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JWS1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JWS1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JWS1" } ], "pmid": "" }, { "name": "regulation of signal transduction", "id": "GO:0009966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009966", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JWS1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JWS1" } ], "pmid": "" }, { "name": "axoneme assembly", "id": "GO:0035082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035082", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JWS1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JWS1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 132, "end_pos": 134, "annotation": "n_glycosylation_sequon" }, { "start_pos": 154, "end_pos": 156, "annotation": "n_glycosylation_sequon" }, { "start_pos": 176, "end_pos": 178, "annotation": "n_glycosylation_sequon" }, { "start_pos": 733, "end_pos": 735, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A0G2JWS1-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 820, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A0G2JWS1-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A0G2JWS1" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.agr", "label": "AGR Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 132, "end_pos": 134 }, { "start_pos": 154, "end_pos": 156 }, { "start_pos": 176, "end_pos": 178 }, { "start_pos": 733, "end_pos": 735 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": 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