{ "uniprot_canonical_ac": "A0A0G2JFS9-1", "uniprot_ac": "A0A0G2JFS9", "uniprot_id": "A0A0G2JFS9_MOUSE", "mass": { "chemical_mass": 45187.0, "monoisotopic_mass": 45187.0 }, "refseq": {}, "gene_names": [ { "name": "Atg4a-ps", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JFS9", "id": "A0A0G2JFS9" } ], "protein_names": [ { "name": "Cysteine protease", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JFS9/entry#names_and_taxonomy", "id": "A0A0G2JFS9" }, { "name": "3.4.22.-", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JFS9/entry#names_and_taxonomy", "id": "A0A0G2JFS9" } ], "function": [ { "annotation": "Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JFS9", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JFS9#function" }, { "database": "UniProtKB", "id": "RU363115", "url": "https://www.uniprot.org/uniprotkb/RU363115#function" } ] } ], "disease": [ { "disease_id": "DOID:162", "recommended_name": { "id": "DOID:162", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:162", "name": "cancer", "description": "A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis." }, "synonyms": [ { "id": "DOID:162", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:162", "name": "malignant neoplasm", "description": "" }, { "id": "DOID:162", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:162", "name": "malignant tumor", "description": "" }, { "id": "DOID:162", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:162", "name": "primary cancer", "description": "" } ], "unlinked_id_list": [ "DOID:184", "DOID:5772", "DOID:175", "DOID:3850", "DOID:660", "DOID:0080364", "DOID:2595", "DOID:201", "DOID:3149", "DOID:3350", "DOID:1294", "DOID:2599", "DOID:2021", "DOID:5604", "DOID:170", "DOID:771", "DOID:0060116", "DOID:4045", "DOID:3001", "DOID:5467", "DOID:3111", "DOID:3675", "DOID:120", "DOID:4706", "DOID:9460", "DOID:2815", "DOID:4203", "DOID:3017", "DOID:0060122", "DOID:368", "DOID:3451", "DOID:0060119", "DOID:5672", "DOID:5093", "DOID:176", "DOID:0050619", "DOID:5032", "DOID:4455", "DOID:0050687", "DOID:4015", "DOID:4230", "DOID:2151", "DOID:4765", "DOID:7757", "DOID:10154", "DOID:3419", "DOID:4907", "DOID:0080638", "DOID:0050938", "DOID:5166", "DOID:3093", "DOID:3973", "DOID:3316", "DOID:1795", "DOID:688", "DOID:3277", "DOID:3095", "DOID:0070003", "DOID:0050615", "DOID:672", "DOID:0080355", "DOID:192", "DOID:2174", "DOID:1542", "DOID:3541", "DOID:3303", "DOID:2621", "DOID:6536", "DOID:0080524", "DOID:0060073", "DOID:1357", "DOID:1039", "DOID:0080639", "DOID:0080879", "DOID:706", "DOID:1659", "DOID:370", "DOID:3112", "DOID:4043", "DOID:8527", "DOID:8858", "DOID:3856", "DOID:5662", "DOID:193", "DOID:4931", "DOID:60004", "DOID:4960", "DOID:4645", "DOID:1036", "DOID:0081452", "DOID:2706", "DOID:4114", "DOID:0080525", "DOID:0060083", "DOID:3479", "DOID:5158", "DOID:1325", "DOID:0060100", "DOID:3953" ], "evidence": [ { "id": "162", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:162" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JFS9", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JFS9" } ], "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "gene": [ { "name": "Atg4a-ps", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JFS9", "locus": { "chromosome": "3", "start_pos": 103551270, "end_pos": 103553384, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000087119", "url": "https://www.ensembl.org/id/ENSMUSG00000087119" } ] } } ], "crossref": [ { "id": "MGI:3615624", "url": "https://alliancegenome.org/gene/MGI:3615624", "database": "AGR", "categories": [ "Protein Classification" ] }, { "id": "A0A0G2JFS9", "url": "https://alphafold.ebi.ac.uk/entry/A0A0G2JFS9", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSMUSG00000087119", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000087119", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "IPR005078", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005078", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038765", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038765", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046792", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046792", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046793", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046793", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "3615624", "url": "http://www.informatics.jax.org/marker/MGI:3615624", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "FPPFVPY", "url": "https://omabrowser.org/oma/group/FPPFVPY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A0G2JFS9", "url": "https://www.orthodb.org/?gene=A0A0G2JFS9", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22624", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22624", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22624:SF35", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22624:SF35", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03416", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF03416", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF20166", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF20166", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "67548", "url": "https://www.rhea-db.org/rhea/67548", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A0G2JFS9", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JFS9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2JFS9-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JFS9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MESVMSKYENQILIFPDYLEEFPDTDELVWILGKQHPFKTEKSKLLSDISARLWFTYRRKFSPIGGTGPSSDAGWGCMLRCGQMMLAQALICRHLGRDWNWERQKEQPKEYQRILQCFLDRKDCCYSIHQMAQMGVGEGKSIGEWFGPNTVAQVIKKLTLFDEWNSLAVYVSMDNTVVIEDIKKMCCVLPVGAADPAGDFLTVSNQSRDTSVPCSAWKPLLLIVPLRLGINQINPVYVEAFKECFKMPQSLGALGGKPNNAYYFIGFLGDELIFLDPHTTQTFVDIEESGLVDDQTFHCLQSPQRMSILNLDPSVALGFFCKEEKDFDNWCSLVQKEILKENLRMFELVQKHPSHWPPFVPPAKPEVTTTGAEFIESTEQLEDFELEEDFEILSVG", "length": 396, "header": "tr|A0A0G2JFS9-1|A0A0G2JFS9_MOUSE Isoform 1 of Cysteine protease OS=Mus musculus OX=10090 GN=Atg4a-ps PE=3 SV=1 CANONICAL=A0A0G2JFS9-1" }, "isoforms": [ { "isoform_ac": "A0A0G2JFS9-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JFS9/entry#A0A0G2JFS9-1", "sequence": { "sequence": "MESVMSKYENQILIFPDYLEEFPDTDELVWILGKQHPFKTEKSKLLSDISARLWFTYRRKFSPIGGTGPSSDAGWGCMLRCGQMMLAQALICRHLGRDWNWERQKEQPKEYQRILQCFLDRKDCCYSIHQMAQMGVGEGKSIGEWFGPNTVAQVIKKLTLFDEWNSLAVYVSMDNTVVIEDIKKMCCVLPVGAADPAGDFLTVSNQSRDTSVPCSAWKPLLLIVPLRLGINQINPVYVEAFKECFKMPQSLGALGGKPNNAYYFIGFLGDELIFLDPHTTQTFVDIEESGLVDDQTFHCLQSPQRMSILNLDPSVALGFFCKEEKDFDNWCSLVQKEILKENLRMFELVQKHPSHWPPFVPPAKPEVTTTGAEFIESTEQLEDFELEEDFEILSVG", "length": 396, "header": "tr|A0A0G2JFS9-1|A0A0G2JFS9_MOUSE Isoform 1 of Cysteine protease OS=Mus musculus OX=10090 GN=Atg4a-ps PE=3 SV=1 CANONICAL=A0A0G2JFS9-1" }, "locus": { "chromosome": "3", "start_pos": 103553339, "end_pos": 103552152, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000117271.3", "url": "https://www.ensembl.org/id/ENSMUST00000117271.3" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000143291.2", "url": "https://www.ensembl.org/id/ENSMUSP00000143291.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Modernizing reference genome assemblies.", "journal": "PLoS Biol.", "date": "2011", "authors": "Church Deanna M, Schneider Valerie A, Graves Tina, Auger Katherine, Cunningham Fiona, Bouk Nathan, Chen Hsiu-Chuan, Agarwala Richa, McLaren William M, Ritchie Graham R S, Albracht Derek, Kremitzki Milinn, Rock Susan, Kotkiewicz Holland, Kremitzki Colin, Wollam Aye, Trani Lee, Fulton Lucinda, Fulton Robert, Matthews Lucy, Whitehead Siobhan, Chow Will, Torrance James, Dunn Matthew, Harden Glenn, Threadgold Glen, Wood Jonathan, Collins Joanna, Heath Paul, Griffiths Guy, Pelan Sarah, Grafham Darren, Eichler Evan E, Weinstock George, Mardis Elaine R, Wilson Richard K, Howe Kerstin, Flicek Paul, Hubbard Tim", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JFS9", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JFS9" } ], "reference": [ { "type": "PubMed", "id": "21750661", "url": "https://glygen.org/publication/PubMed/21750661" } ] } ], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2QC33-1", "protein_name": "Cysteine protease ATG4B", "gene_name": "Atg4b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDAATLTYDTLRFAEFEDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRRNFPAIGGTGPTSDTGWGCMLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFLDRKDSYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIRRLCRASLPCAGAAALSMESERHCNGLPAGAEVTNRPLAWRPLVLLIPLRLGLTDINEAYVETLKHCFMMPQSLGVIGGKPNSAHYFIGYVGEELIYLDPHTTQPAVELTDSCFIPDESFHCQHPPCRMGIGELDPSIAVGFFCKTEEDFNDWCQQVKKLSQLGGALPMFELVEQQPSHLACQDVLNLSLDSSDVERLERFFDSEDEDFEILSL", "length": 393 }, "evidence": [ { "id": "FB:FBgn0031298", "url": "https://alliancegenome.org/gene/FB:FBgn0031298#orthology", "database": "AGR" }, { "id": "SGD:S000005167", "url": "https://alliancegenome.org/gene/SGD:S000005167#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I5ZXZ8-1", "protein_name": "Cysteine protease", "gene_name": "Atg4c", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEASGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFSRNSPVLLLGKCYHFKYEDESKVLPARSGCAIEDHVIAGNVEEFRKDFISRIWLTYREEFPQIEASALTTDCGWGCTLRTGQMLLAQGLILHFLGRAWTWPDALHIESSDSDSWTSNTIHKFTASFEASLSGERELRTPAVSLKETSGKHPDDHAVQSEIYHRQIISWFGDSPVAVFGLHRLIEFGKKSGKKAGDWYGPAVVAHILRKAVEEARHPDLQGLTIYVAQDCTVYNSDVIDKQTDSVTAGDARDKAVIILVPVRLGGERTNIDYLEFVKGVLSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDVSIKDFPLETFHCPSPKKMSFRKMDPSCTIGFYCRNVQDFERASEEITKMLKISSKEKYPLFTFVNGHSRDFDFTSTAASEEDLFLEDEKKNFKRFSTEEFVLL", "length": 458 }, "evidence": [ { "id": "SGD:S000005167", "url": "https://alliancegenome.org/gene/SGD:S000005167#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6AIP9-1", "protein_name": "Cysteine protease", "gene_name": "Atg4a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MFTCLHFLLVMSKYENQIIIFTEYLEEFPDTDELVWILGKPHLLKTEKSKLLSDISARLWFTYRRKFSPIGGTGPSSDAGWGCMLRCGQMMLAQALICRHLGRDWNWERQKEQPKEYQRILQCFLDRKDCCYSIHQMAQMGVGEGKSIGEWFGPNTVAQVIKKLALFDEWNSLAVYVSMDNTVVIEDIKKMCCVLPVGAADTAGESPPDSLIASSQSKGTSAPCLAWKPLLLIVPLRLGINQINPVYIEAFKECFKMPQSLGALGGKPNNAYYFIGSLGDELIFLDPHTTQTFVDTEESGLVDDHTFHCLQSPQRMSILNLDPSVALGFFCKEEKDFDNWCSLVQKEILKENLRMFELVQKHPSHWPPFVPPAKPEVTTTGAEFIDSTEQLEDFDLEEDFEILSV", "length": 405 }, "evidence": [ { "id": "HGNC:16489", "url": "https://alliancegenome.org/gene/HGNC:16489#orthology", "database": "AGR" }, { "id": "RGD:1596915", "url": "https://alliancegenome.org/gene/RGD:1596915#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-050522-430", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-050522-430#orthology", "database": "AGR" }, { "id": "FB:FBgn0031298", "url": "https://alliancegenome.org/gene/FB:FBgn0031298#orthology", "database": "AGR" }, { "id": "MGI:3615624", "url": "https://alliancegenome.org/gene/MGI:3615624#orthology", "database": "AGR" }, { "id": "SGD:S000005167", "url": "https://alliancegenome.org/gene/SGD:S000005167#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8M3B835-1", "protein_name": "Cysteine protease", "gene_name": "atg4db", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDVSDASEEFNGEMESADDLASFEVVNMSNPGLLDFSADVQGSKEKTKLKSKLMSAWHNVRYRGWSLKSKPRLSKSSPVCLLGQSYQLSSTGVRESFRRVFSSLLWMSYRRGFRPLDGSTLSSDAGWGCMLRSAQMLLAQGLLLHIMPNGWTWPATHNQTKDDLEVLDAHGSLRHSGKSRRCSLGSALDGESHEERSHRRIVSWFGDLPSAPFGLHRLVELGRAFGKRAGDWYGPAIAAHILQKAVSASELSDLVVYVAQDCTVYTGDVLNLCRTSRTDASWRSTSGWKSLVLLVPVRLGSDGLNPVYTGCVKRLLELRCCLGIIGGKPKHSLYFLGFQNDQLIYLDPHYCQSAVDVQQDHFPLESFHCKTVRKMAFSRMDPSCTVGFYARSRADFHSLCSDVSKALSSSEQKYPIFTFVEGHSEGQSGSTSDMDITHTKTKDKLRRNQKRSSTEEFVLL", "length": 460 }, "evidence": [ { "id": "SGD:S000005167", "url": "https://alliancegenome.org/gene/SGD:S000005167#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "M0R5T6-1", "protein_name": "Cysteine protease", "gene_name": "Atg4d", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MNSVSPAAAQYRSGSPEDARRPDCRRPRGQTRIPDPSNLGPSGSGVAALGSTGTDPAEPDEVDKFKTKFLTAWNNVKYGWAVKSRTSFSKISSVHLCGRCYHFEGEGDIQRFQRDFVSRLWLTYRRDFPPLAGSLTSDCGWGCMLRSGQMMLAQGLLLHFLPRDWRWVEGTGLASSEMPGPASPSRYRGPGRRGPLRCAQGALEMEPDRWHRRIVSWFADHPQAPFGLHRLVELGQSSGKKAGDWYGPSVVAHILRKAVESCSEVTRLVVYVSQDCTVYKADVARLVSWPDPTAEWKSVVILVPVRLGGETLNPVYVPCVKELLRSELCLGIMGGKPRHSLYFIGYQDDFLLYLDPHYCQPTVDVNQANFPLESFHCTSPRKMAFAKMDPSCTVGFYAGNRKEFETLCSELMRILSSSSVTERYPMFTVAEGHAQDHSLDALCTQLSQPTLRLPCTGRLLKAKRPSSEDFVFL", "length": 473 }, "evidence": [ { "id": "SGD:S000005167", "url": "https://alliancegenome.org/gene/SGD:S000005167#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P53867-1", "protein_name": "Cysteine protease ATG4", "gene_name": "ATG4", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MQRWLQLWKMDLVQKVSHGVFEGSSEEPAALMNHDYIVLGEVYPERDEESGAEQCEQDCRYRGEAVSDGFLSSLFGREISSYTKEFLLDVQSRVNFTYRTRFVPIARAPDGPSPLSLNLLVRTNPISTIEDYIANPDCFNTDIGWGCMIRTGQSLLGNALQILHLGRDFRVNGNESLERESKFVNWFNDTPEAPFSLHNFVSAGTELSDKRPGEWFGPAATARSIQSLIYGFPECGIDDCIVSVSSGDIYENEVEKVFAENPNSRILFLLGVKLGINAVNESYRESICGILSSTQSVGIAGGRPSSSLYFFGYQGNEFLHFDPHIPQPAVEDSFVESCHTSKFGKLQLSEMDPSMLIGILIKGEKDWQQWKLEVAESAIINVLAKRMDDFDVSCSMDDVESVSSNSMKKDASNNENLGVLEGDYVDIGAIFPHTTNTEDVDEYDCFQDIHCKKQKIVVMGNTHTVNANLTDYEVEGVLVEKETVGIHSPIDEKC", "length": 494 }, "evidence": [ { "id": "HGNC:16489", "url": "https://alliancegenome.org/gene/HGNC:16489#orthology", "database": "AGR" }, { "id": "RGD:1596915", "url": "https://alliancegenome.org/gene/RGD:1596915#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-050522-430", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-050522-430#orthology", "database": "AGR" }, { "id": "FB:FBgn0031298", "url": "https://alliancegenome.org/gene/FB:FBgn0031298#orthology", "database": "AGR" }, { "id": "MGI:3615624", "url": "https://alliancegenome.org/gene/MGI:3615624#orthology", "database": "AGR" }, { "id": "SGD:S000005167", "url": "https://alliancegenome.org/gene/SGD:S000005167#orthology", "database": "AGR" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q4VBK1-1", "protein_name": "Cysteine protease", "gene_name": "atg4a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MEAVLAKYENQINVFLEDLPDTDEPVWILGACYNVKTKKSELLSDVRSRLWFTYRKKFSPIGGTGPSSDAGWGCMLRCGQMILAQALICSHLGRDWRWDPEKHQPKEYQRILDCFLDKKDSCYSIHQMAQMGVGEGKSVGEWYGPNTVAQVLKKLALFDDWNSLSVYVSMDNTVVIEDIKKLCVRADLQLQSQQPLDWRPLLLVIPLRMGINSINPVYIQALKECFKMPQSCGVLGGKPNLAYYFIGFIDDELIYLDPHTTQQAVDTESGSAVDDQSFHCQRTPHRMKITSLDPSVALGFFCKSEEDFDSWCDLVQQELLKKRNLRMFELVEKHPSHWPPFVPPTKPEVQTTGAEFIESPDKLSESEEEFEILNA", "length": 375 }, "evidence": [ { "id": "HGNC:16489", "url": "https://alliancegenome.org/gene/HGNC:16489#orthology", "database": "AGR" }, { "id": "RGD:1596915", "url": "https://alliancegenome.org/gene/RGD:1596915#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-050522-430", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-050522-430#orthology", "database": "AGR" }, { "id": "FB:FBgn0031298", "url": "https://alliancegenome.org/gene/FB:FBgn0031298#orthology", "database": "AGR" }, { "id": "MGI:3615624", "url": "https://alliancegenome.org/gene/MGI:3615624#orthology", "database": "AGR" }, { "id": "SGD:S000005167", "url": "https://alliancegenome.org/gene/SGD:S000005167#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q6DG88-1", "protein_name": "Cysteine protease ATG4B", "gene_name": "atg4b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDAATLTYDSLRFGEIEDFPETSDPVWILGKQFSALTEKDDILADVTSRLWFTYRKNFQPIGGTGPTSDTGWGCMLRCGQMILGEALICRHLGRDWKWSPGQRQRPEYVSILNAFIDKKDSYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDSWSRLAVHVAMDNTVVIEEIKRLCMPWLDFDRGACAVSEEPREMNGDLEGACALAEEETALWKPLVLLIPLRLGLSDINEAYIEPLKQCFMMPQSLGVIGGKPNSAHYFIGFVGDELIYLDPHTTQPAVDPSEDGHFPDDSYHCQHPPCRMHICELDPSIAAGFFCQTEDDFDDWCAQIRKVSNCRGLPMFELVDSQPSHLITADVLNLTPDFSDSDRLERFFDSEDEEFEILSL", "length": 394 }, "evidence": [ { "id": "FB:FBgn0031298", "url": "https://alliancegenome.org/gene/FB:FBgn0031298#orthology", "database": "AGR" }, { "id": "SGD:S000005167", "url": "https://alliancegenome.org/gene/SGD:S000005167#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q6IQ96-1", "protein_name": "Cysteine protease", "gene_name": "atg4c", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "METKGTDEVETLKSKFMSAWHSVKYSWALKSKTAFSRNSPVFLLGKCYHFKVVDDENPTESTAEALDDDVVTGNVDEFRKDFTSRVWLTYREEFPALPGSSFTSDCGWGCTLRAGQMILAQALLLHILGRDWKWSEALSLEPLDTETWTSSAARRLVATLEASIQGERAQASQPLCPVQGEAEEADSYLKETYHRTIVSWFGDGPSAQLGIYKLVELGMTSGKQAGDWYGPAVVAHILRKAVDEAVDAMLKGIRVYVAQDCTVYSADVIDSHSTRTESHSDPQGLDSGASPDSRAVVILIPVRLGGEKINPEYLNFVKSILSLEYCIGIIGGKPKQAYYFVGFQDDSLIYMDPHYCQSFVDVSTSDFPLQSFHCPSPKKMSFSKMDPSCTIGFYSKSVEHFEKIANELSKILQPSSKEKYPAFTIMKGHGKDYELSIAVEKREWPFIRDARKAGTTSGDFVLL", "length": 463 }, "evidence": [ { "id": "SGD:S000005167", "url": "https://alliancegenome.org/gene/SGD:S000005167#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q811C2-1", "protein_name": "Cysteine protease ATG4C", "gene_name": "Atg4c", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEASGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFSRNSPVLLLGKCYHFKYEDESKMLPARSGCAIEDHVIAGNVEEFRKDFISRIWLTYREEFPQIEASALTTDCGWGCTLRTGQMLLAQGLILHFLGRAWTWPDALHIENADSDSWTSNTVKKFTASFEASLSGDRELRTPAVSLKETSGKCPDDHAVRNEAYHRKIISWFGDSPVAVFGLHRLIEFGKKSGKKAGDWYGPAVVAHILRKAVEEARHPDLQGLTIYVAQDCTVYNSDVIDKQTDSVTAGDARDKAVIILVPVRLGGERTNTDYLEFVKGVLSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDVSIKDFPLETFHCPSPKKMSFRKMDPSCTIGFYCRNVQDFERASEEITKMLKISSKEKYPLFTFVNGHSKDFDFTSTAASEEDLFSEDERKNFKRFSTEEFVLL", "length": 458 }, "evidence": [ { "id": "SGD:S000005167", "url": "https://alliancegenome.org/gene/SGD:S000005167#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q86TL0-1", "protein_name": "Cysteine protease ATG4D", "gene_name": "ATG4D", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MNSVSPAAAQYRSSSPEDARRRPEARRPRGPRGPDPNGLGPSGASGPALGSPGAGPSEPDEVDKFKAKFLTAWNNVKYGWVVKSRTSFSKISSIHLCGRRYRFEGEGDIQRFQRDFVSRLWLTYRRDFPPLPGGCLTSDCGWGCMLRSGQMMLAQGLLLHFLPRDWTWAEGMGLGPPELSGSASPSRYHGPARWMPPRWAQGAPELEQERRHRQIVSWFADHPRAPFGLHRLVELGQSSGKKAGDWYGPSLVAHILRKAVESCSDVTRLVVYVSQDCTVYKADVARLVARPDPTAEWKSVVILVPVRLGGETLNPVYVPCVKELLRCELCLGIMGGKPRHSLYFIGYQDDFLLYLDPHYCQPTVDVSQADFPLESFHCTSPRKMAFAKMDPSCTVGFYAGDRKEFETLCSELTRVLSSSSATERYPMFTLAEGHAQDHSLDDLCSQLAQPTLRLPRTGRLLRAKRPSSEDFVFL", "length": 474 }, "evidence": [ { "id": "SGD:S000005167", "url": "https://alliancegenome.org/gene/SGD:S000005167#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BGE6-1", "protein_name": "Cysteine protease ATG4B", "gene_name": "Atg4b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDAATLTYDTLRFAEFEDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRRNFPAIGGTGPTSDTGWGCMLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFNVLNAFLDRKDSYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIRRLCRANLPCAGAAALPTDSERHCNGFPAGAEVTNRPSAWRPLVLLIPLRLGLTDINEAYVETLKHCFMMPQSLGVIGGKPNSAHYFIGYVGEELIYLDPHTTQPAVELTDSCFIPDESFHCQHPPSRMGIGELDPSIAVGFFCKTEEDFNDWCQQVKKLSQLGGALPMFELVEQQPSHLACQDVLNLSLDSSDVERLERFFDSEDEDFEILSL", "length": 393 }, "evidence": [ { "id": "FB:FBgn0031298", "url": "https://alliancegenome.org/gene/FB:FBgn0031298#orthology", "database": "AGR" }, { "id": "SGD:S000005167", "url": "https://alliancegenome.org/gene/SGD:S000005167#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8BGV9-1", "protein_name": "Cysteine protease ATG4D", "gene_name": "Atg4d", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNSVSPAAAQYRSGSSEDARRADCRRPRGQTRIPDPSNLGPSGSGVAALGSSGTDPAEPDEVDKFKAKFLTAWNNVKYGWAVKSRTSFSKISTVHLCGRCYHFEGEGDIQRFQRDFVSRLWLTYRRDFPPLAGGSLTSDCGWGCMLRSGQMMLAQGLLLHFLPRDWRWVEGTGLASSEMPGPASPSRCRGPGRRGPPRWTQGALEMEQDRWHRRIVSWFADHPRAPFGLHRLVELGRSSGKKAGDWYGPSVVAHILRKAVESCSEVSRLVVYVSQDCTVYKADVARLLSWPDPTAEWKSVVILVPVRLGGETLNPVYVPCVKELLRSELCLGIMGGKPRHSLYFIGYQDDFLLYLDPHYCQPTVDVSQPSFPLESFHCTSPRKMAFAKMDPSCTVGFYAGNRKEFETLCSELMRILSSSSVTERYPMFTVAEGHAQDHSLDALCTQLSQPTLRLPCTGRLLKAKRPSSEDFVFL", "length": 474 }, "evidence": [ { "id": "SGD:S000005167", "url": "https://alliancegenome.org/gene/SGD:S000005167#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8C9S8-1", "protein_name": "Cysteine protease ATG4A", "gene_name": "Atg4a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MESVMSKYENQILIFPDYLEEFPDTDELVWILGKQHPLKTEKSKLLSDISARLWFTYRRKFSPIGGTGPSSDAGWGCMLRCGQMMLAQALICRHLGRDWNWERQKEQPKEYQRILQCFLDRKDCCYSIHQMAQMGVGEGKSIGEWFGPNTVAQVIKKLALFDEWNSLAVYVSMDNTVVIEDIKKMCCVLPVGAADPAGDFLTASNQSRDTSVPCSAWKPLLLIVPLRLGINQINPVYVEAFKECFKMPQSLGALGGKPNNAYYFIGFLGDELIFLDPHTTQTFVDIEESGLVDDQTFHCLQSPQRMSILNLDPSVALGFFCKEEKDFDNWCSLVQKEILKENLRMFELVQKHPSHWPPFVPPAKPEVTTTGAEFIESTEQLEDFELEEDFEILSVG", "length": 396 }, "evidence": [ { "id": "HGNC:16489", "url": "https://alliancegenome.org/gene/HGNC:16489#orthology", "database": "AGR" }, { "id": "RGD:1596915", "url": "https://alliancegenome.org/gene/RGD:1596915#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-050522-430", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-050522-430#orthology", "database": "AGR" }, { "id": "FB:FBgn0031298", "url": "https://alliancegenome.org/gene/FB:FBgn0031298#orthology", "database": "AGR" }, { "id": "SGD:S000005167", "url": "https://alliancegenome.org/gene/SGD:S000005167#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8WYN0-1", "protein_name": "Cysteine protease ATG4A", "gene_name": "ATG4A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MESVLSKYEDQITIFTDYLEEYPDTDELVWILGKQHLLKTEKSKLLSDISARLWFTYRRKFSPIGGTGPSSDAGWGCMLRCGQMMLAQALICRHLGRDWSWEKQKEQPKEYQRILQCFLDRKDCCYSIHQMAQMGVGEGKSIGEWFGPNTVAQVLKKLALFDEWNSLAVYVSMDNTVVIEDIKKMCRVLPLSADTAGDRPPDSLTASNQSKGTSAYCSAWKPLLLIVPLRLGINQINPVYVDAFKECFKMPQSLGALGGKPNNAYYFIGFLGDELIFLDPHTTQTFVDTEENGTVNDQTFHCLQSPQRMNILNLDPSVALGFFCKEEKDFDNWCSLVQKEILKENLRMFELVQKHPSHWPPFVPPAKPEVTTTGAEFIDSTEQLEEFDLEEDFEILSV", "length": 398 }, "evidence": [ { "id": "HGNC:16489", "url": "https://alliancegenome.org/gene/HGNC:16489#orthology", "database": "AGR" }, { "id": "RGD:1596915", "url": "https://alliancegenome.org/gene/RGD:1596915#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-050522-430", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-050522-430#orthology", "database": "AGR" }, { "id": "FB:FBgn0031298", "url": "https://alliancegenome.org/gene/FB:FBgn0031298#orthology", "database": "AGR" }, { "id": "MGI:3615624", "url": "https://alliancegenome.org/gene/MGI:3615624#orthology", "database": "AGR" }, { "id": "SGD:S000005167", "url": "https://alliancegenome.org/gene/SGD:S000005167#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q96DT6-1", "protein_name": "Cysteine protease ATG4C", "gene_name": "ATG4C", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEATGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFSRNSPVLLLGKCYHFKYEDEDKTLPAESGCTIEDHVIAGNVEEFRKDFISRIWLTYREEFPQIEGSALTTDCGWGCTLRTGQMLLAQGLILHFLGRAWTWPDALNIENSDSESWTSHTVKKFTASFEASLSGEREFKTPTISLKETIGKYSDDHEMRNEVYHRKIISWFGDSPLALFGLHQLIEYGKKSGKKAGDWYGPAVVAHILRKAVEEARHPDLQGITIYVAQDCTVYNSDVIDKQSASMTSDNADDKAVIILVPVRLGGERTNTDYLEFVKGILSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDVSIKDFPLETFHCPSPKKMSFRKMDPSCTIGFYCRNVQDFKRASEEITKMLKFSSKEKYPLFTFVNGHSRDYDFTSTTTNEEDLFSEDEKKQLKRFSTEEFVLL", "length": 458 }, "evidence": [ { "id": "SGD:S000005167", "url": "https://alliancegenome.org/gene/SGD:S000005167#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VF80-1", "protein_name": "Cysteine protease", "gene_name": "Atg4b", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MNYDGLLSKLTDEKLMLFEAAGEGTIVEGSRICGQDADPLSLPLVEDGAIEEEQAAPIQTIHRTVFAVPRVPSPSPVSTSGANLNLKTENAATATPQRKISTSSRFMNAFSQLYGGGNSGPSCGHVEQHNEEPGDLSANRTPTKGMESKLVAMWHNVKYGWSGKMRQTSFSKEQPVWLLGRCYHRRFTPPVSMESSITELPSGADTTPDNATSAFDSIQATSTSTSLYPALNPQQIDEIVVPQELGMDAVENQVGEQPWEEGIEGFRRDFYSRIWMTYRREFPIMNGSNYTSDCGWGCMLRSGQMLFAQGLICHFLGRSWRYDSESQLHSTYEDNMHKKIVKWFGDSSSKSSPFSIHALVRLGEHLGKKPGDWYGPASVSYLLKHALEHAAQENADFDNISVYVAKDCTIYLQDIEDQCSIPEPAPKPHVPWQQAKRPQAETTKTEQQQHWKSLIVLIPLRLGSDKLNPVYAHCLKLLLSTEHCLGILGGKPKHSLYFVGFQEDRLIHLDPHYCQEMVDVNQENFSLHSFHCKSPRKLKASKMDPSCCIGFYCATKSDFDNFMESVQLYLHPMRCASGATVDKAAGSHHTTPQSSHQTEQTEMNYPLFSFSRGRCMDHERDEMSDSLYKPLIKQVASLAQELGAQLAPPQHGDEHDQDDSESEEFVLL", "length": 668 }, "evidence": [ { "id": "SGD:S000005167", "url": "https://alliancegenome.org/gene/SGD:S000005167#orthology", "database": "AGR" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9VPW2-1", "protein_name": "Cysteine protease", "gene_name": "Atg4a", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MLVGLSDQLARIMESVFEAYLGPDSVLASAVGQAVGSGEPEDIPRRNTDVWVLGKKYNAIQELELIRRDIQSRLWCTYRHGFSPLGEVQLTTDKGWGCMLRCGQMVLAQALIDLHLGRDWFWTPDCRDATYLKIVNRFEDVRNSFYSIHQIAQMGESQNKAVGEWLGPNTVAQILKKLVRFDDWSSLAIHVAMDSTVVLDDVYASCREGGSWKPLLLIIPLRLGITDINPLYVPALKRCLELDSSCGMIGGRPNQALYFLGYVDDEVLYLDPHTTQRTGAVAQKTAAAEQDYDETYHQKHAARLNFSAMDPSLAVCFLCKTSDSFESLLTKLKEEVLSLCSPALFEISQTRAVDWDTTEDIDWPTMPDIDWPAGTSDSDSFAIVEESGRDSDAGCSGAIGSGKKPSERAVI", "length": 411 }, "evidence": [ { "id": "HGNC:16489", "url": "https://alliancegenome.org/gene/HGNC:16489#orthology", "database": "AGR" }, { "id": "RGD:1596915", "url": "https://alliancegenome.org/gene/RGD:1596915#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-050522-430", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-050522-430#orthology", "database": "AGR" }, { "id": "FB:FBgn0031298", "url": "https://alliancegenome.org/gene/FB:FBgn0031298#orthology", "database": "AGR" }, { "id": "MGI:3615624", "url": "https://alliancegenome.org/gene/MGI:3615624#orthology", "database": "AGR" }, { "id": "SGD:S000005167", "url": "https://alliancegenome.org/gene/SGD:S000005167#orthology", "database": "AGR" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9Y4P1-1", "protein_name": "Cysteine protease ATG4B", "gene_name": "ATG4B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MDAATLTYDTLRFAEFEDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRKNFPAIGGTGPTSDTGWGCMLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFIDRKDSYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIRRLCRTSVPCAGATAFPADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGLTDINEAYVETLKHCFMMPQSLGVIGGKPNSAHYFIGYVGEELIYLDPHTTQPAVEPTDGCFIPDESFHCQHPPCRMSIAELDPSIAVGFFCKTEDDFNDWCQQVKKLSLLGGALPMFELVELQPSHLACPDVLNLSLDSSDVERLERFFDSEDEDFEILSL", "length": 393 }, "evidence": [ { "id": "FB:FBgn0031298", "url": "https://alliancegenome.org/gene/FB:FBgn0031298#orthology", "database": "AGR" }, { "id": "SGD:S000005167", "url": "https://alliancegenome.org/gene/SGD:S000005167#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "R4GER2-1", "protein_name": "Cysteine protease atg4da", "gene_name": "atg4da", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MNSVSPSAVQYIVGGGAHEDKASASSKRHLGHGAVPDGIREGSGEPDEVDRLKAKFMSAWNNVKYGWTVKSKTSFNKSSPLILLGQSFLFNNEDEVERFRQTFVSCVWLTYRREFPQLDGSSLTTDCGWGCMLRSGQMMLAQGLLLHLMPTDWRWSDCHALTDVDFEVLKPRSPSRPAGMSMPSFSSSWSSSIPQINPSPGITEAHRRAPARCPSASPDPQVDALHRKVVSCFGDHPSAPFGVHQLVELGKESGKRAGDWYGPSVVAHMLRKAVARAAEFEDLAVYVAQDCTVYKEDVMSLCESSGVGWKSVVILVPVRLGGESLNPSYIECVKNILKLKCCIGIIGGKPKHSLFFVGFQDEQLLYLDPHYCQPVVDVTQANFSLESFHCNSPRKMNFSRMDPSCTIGLYARSKTDFESLCTAVSEALSSSKEKYPIFTFVEGRGQIYGMEGPSGGSVDAPAHIFTCSRLSRNNKRGSTDEFVLL", "length": 485 }, "evidence": [ { "id": "SGD:S000005167", "url": "https://alliancegenome.org/gene/SGD:S000005167#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JFS9", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JFS9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JFS9", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JFS9" } ], "pmid": "" }, { "name": "lipid metabolic process", "id": "GO:0006629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006629", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JFS9", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JFS9" } ], "pmid": "" }, { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JFS9", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JFS9" } ], "pmid": "" }, { "name": "autophagy", "id": "GO:0006914", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006914", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JFS9", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JFS9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "cysteine-type peptidase activity", "id": "GO:0008234", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008234", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JFS9", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JFS9" } ], "pmid": "" }, { "name": "protein-phosphatidylethanolamide deconjugating activity", "id": "GO:0019786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019786", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JFS9", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JFS9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 205, "end_pos": 207, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "67548", "name": "", "equation": "[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8C9S8-1", "Q8BGE6-1", "A0A0G2JFS9-1", "Q811C2-1", "Q8BGV9-1" ], "evidence": [ { "id": "67548", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/67548" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A0G2JFS9", "gene_name": "Atg4a-ps", "activity": [ { "ec_number": "3.4.22.-", "activity": "", "evidence": [ { "id": "A0A0G2JFS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JFS9" } ] } ] }, { "uniprot_ac": "Q811C2", "gene_name": "Atg4c", "activity": [ { "ec_number": "3.4.22.-", "activity": "", "evidence": [ { "id": "Q811C2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q811C2" } ] } ] }, { "uniprot_ac": "Q8BGE6", "gene_name": "Atg4b", "activity": [ { "ec_number": "3.4.22.-", "activity": "", "evidence": [ { "id": "Q8BGE6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8BGE6" } ] } ] }, { "uniprot_ac": "Q8BGV9", "gene_name": "Atg4d", "activity": [ { "ec_number": "3.4.22.-", "activity": "", "evidence": [ { "id": "Q8BGV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8BGV9" } ] } ] }, { "uniprot_ac": "Q8C9S8", "gene_name": "Atg4a", "activity": [ { "ec_number": "3.4.22.-", "activity": "", "evidence": [ { "id": "Q8C9S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q8C9S8" } ] } ] } ], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A0G2JFS9-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 396, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A0G2JFS9-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A0G2JFS9" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.agr", "label": "AGR Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 205, "end_pos": 207 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }