{ "uniprot_canonical_ac": "A0A0G2JDV3-1", "uniprot_ac": "A0A0G2JDV3", "uniprot_id": "GBP6_MOUSE", "mass": { "chemical_mass": 70443.0, "monoisotopic_mass": 70443.0 }, "refseq": {}, "gene_names": [ { "name": "Gbp6", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JDV3", "id": "A0A0G2JDV3" }, { "name": "Mpa2l", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JDV3", "id": "A0A0G2JDV3" } ], "protein_names": [ { "name": "Guanylate-binding protein 6", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JDV3/entry#names_and_taxonomy", "id": "A0A0G2JDV3" }, { "name": "3.6.5.-", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JDV3/entry#names_and_taxonomy", "id": "A0A0G2JDV3" }, { "name": "GBP-6", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JDV3/entry#names_and_taxonomy", "id": "A0A0G2JDV3" }, { "name": "GTP-binding protein 6", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JDV3/entry#names_and_taxonomy", "id": "A0A0G2JDV3" }, { "name": "Guanine nucleotide-binding protein 6", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JDV3/entry#names_and_taxonomy", "id": "A0A0G2JDV3" }, { "name": "Macrophage activation 2 like protein", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JDV3/entry#names_and_taxonomy", "id": "A0A0G2JDV3" } ], "function": [ { "annotation": "Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens, such as bacterial pathogens Listeria monocytogenes and Mycobacterium bovis BCG as well as the protozoan pathogen Toxoplasma gondii (PubMed:18025219, PubMed:21551061). Confers protection to several pathogens, including the bacterial pathogens Listeria monocytogenes and Mycobacterium bovis BCG as well as the protozoan pathogen Toxoplasma gondii (PubMed:18025219, PubMed:21551061).", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JDV3", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JDV3#function" }, { "database": "PubMed", "id": "18025219", "url": "https://glygen.org/publication/PubMed/18025219" }, { "database": "PubMed", "id": "21551061", "url": "https://glygen.org/publication/PubMed/21551061" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JDV3", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JDV3" } ], "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "gene": [ { "name": "Gbp6", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JDV3", "locus": { "chromosome": "5", "start_pos": 105418568, "end_pos": 105441564, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000104713", "url": "https://www.ensembl.org/id/ENSMUSG00000104713" } ] } } ], "crossref": [ { "id": "MGI:2140937", "url": "https://alliancegenome.org/gene/MGI:2140937", "database": "AGR", "categories": [ "Protein Classification" ] }, { "id": "A0A0G2JDV3", "url": "https://alphafold.ebi.ac.uk/entry/A0A0G2JDV3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSMUSG00000104713", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000104713", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01851", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01851", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd16269", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16269", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "100702", "url": "https://www.ncbi.nlm.nih.gov/gene/100702", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "116243", "url": "https://www.iedb.org/epitope/116243", "database": "IEDB", "categories": [ "Other" ] }, { "id": "148272", "url": "https://www.iedb.org/epitope/148272", "database": "IEDB", "categories": [ "Other" ] }, { "id": "1556573", "url": "https://www.iedb.org/epitope/1556573", "database": "IEDB", "categories": [ "Other" ] }, { "id": "61982", "url": "https://www.iedb.org/epitope/61982", "database": "IEDB", "categories": [ "Other" ] }, { "id": "918105", "url": "https://www.iedb.org/epitope/918105", "database": "IEDB", "categories": [ "Other" ] }, { "id": "985051", "url": "https://www.iedb.org/epitope/985051", "database": "IEDB", "categories": [ "Other" ] }, { "id": "IPR003191", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003191", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015894", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015894", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030386", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030386", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036543", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036543", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037684", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037684", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:100702", "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:100702", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "2140937", "url": "http://www.informatics.jax.org/marker/MGI:2140937", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "KCEEMNE", "url": "https://omabrowser.org/oma/group/KCEEMNE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "LCDMDDQ", "url": "https://omabrowser.org/oma/group/LCDMDDQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A8Q0QEH4", "url": "https://www.orthodb.org/?gene=A0A8Q0QEH4", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10751", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10751", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02263", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02263", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02841", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF02841", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_A0A0G2JDV3", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=PR:PR_A0A0G2JDV3", "database": "PRO", "categories": [ "Protein" ] }, { "id": "19669", "url": "https://www.rhea-db.org/rhea/19669", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A0G2JDV3", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JDV3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2JDV3-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JDV3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2JF24", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JF24", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2JF24-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JF24-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8Q0QEH4", "url": "https://www.uniprot.org/uniprotkb/A0A8Q0QEH4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8Q0QEH4-1", "url": "https://www.uniprot.org/uniprotkb/A0A8Q0QEH4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTQPQMAPICLVENHNEQLSVNQEAIEILDKISQPVVVVAIVGLYRTGKSYLMNCLAGQNHGFPLGSTVQSQTKGIWMWCMPHPTKPEHTLVLLDTEGLGDVEKGDPKNDLWIFALSVLLSSTFIYNSMITINHQALEQLQYVTELTELIRAKSSPNPAGIKNSTEFVSFFPDFVWTVRDFMLELKLNGEDITSDDYLENALKLIPGDKPRMQASNSCRECIRLFFPNRKCFVFDRPTHDKELLQKLDSITEDQLDPKFQEVTKAFVSYIFTYAKIKTLKEGIKVTGNRLGILVTTYVNAINSGAVPCLDDAVTTLAQRENSVAVQKAADHYSEQMAQRLRLPTETLQELLDVHAACEKEAMAVFMEHSFKDENQQFLKKLVELIGENKELFLSKNEEASNKYCQEELDRLSKDFMENISTFFVPCGHKLYMDKREKIEHDYWQVPRKGVKASEVFQSFLQSQAFIESSILQADTALTAGEKAIAEERAQKVAAEKEQELLRQKQKEQQEYMEAQEKSHKENLEQLRRKLEQEREQDIKDHDMMLKKLMKDQKAFLEEGFKKKAEEMNKEIQQLRDVIKDKKRNTDRIKEALLNGFSTVLFHYLVRYLKHL", "length": 611, "header": "sp|A0A0G2JDV3-1|GBP6_MOUSE Isoform 1 of Guanylate-binding protein 6 OS=Mus musculus OX=10090 GN=Gbp6 PE=2 SV=2 CANONICAL=A0A0G2JDV3-1" }, "isoforms": [ { "isoform_ac": "A0A0G2JDV3-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JDV3/entry#A0A0G2JDV3-1", "sequence": { "sequence": "MTQPQMAPICLVENHNEQLSVNQEAIEILDKISQPVVVVAIVGLYRTGKSYLMNCLAGQNHGFPLGSTVQSQTKGIWMWCMPHPTKPEHTLVLLDTEGLGDVEKGDPKNDLWIFALSVLLSSTFIYNSMITINHQALEQLQYVTELTELIRAKSSPNPAGIKNSTEFVSFFPDFVWTVRDFMLELKLNGEDITSDDYLENALKLIPGDKPRMQASNSCRECIRLFFPNRKCFVFDRPTHDKELLQKLDSITEDQLDPKFQEVTKAFVSYIFTYAKIKTLKEGIKVTGNRLGILVTTYVNAINSGAVPCLDDAVTTLAQRENSVAVQKAADHYSEQMAQRLRLPTETLQELLDVHAACEKEAMAVFMEHSFKDENQQFLKKLVELIGENKELFLSKNEEASNKYCQEELDRLSKDFMENISTFFVPCGHKLYMDKREKIEHDYWQVPRKGVKASEVFQSFLQSQAFIESSILQADTALTAGEKAIAEERAQKVAAEKEQELLRQKQKEQQEYMEAQEKSHKENLEQLRRKLEQEREQDIKDHDMMLKKLMKDQKAFLEEGFKKKAEEMNKEIQQLRDVIKDKKRNTDRIKEALLNGFSTVLFHYLVRYLKHL", "length": 611, "header": "sp|A0A0G2JDV3-1|GBP6_MOUSE Isoform 1 of Guanylate-binding protein 6 OS=Mus musculus OX=10090 GN=Gbp6 PE=2 SV=2 CANONICAL=A0A0G2JDV3-1" }, "locus": {} }, { "isoform_ac": "A0A0G2JF24-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JDV3/entry#A0A0G2JF24-1", "sequence": { "sequence": "MTQPQMAPICLVENHNEQLSVNQEAIEILDKISQPVVVVAIVGLYRTGKSYLMNCLAGQNHG", "length": 62, "header": "tr|A0A0G2JF24-1|A0A0G2JF24_MOUSE Computationally mapped isoform of Guanylate binding protein 6 OS=Mus musculus OX=10090 GN=Gbp6 PE=3 SV=1 CANONICAL=A0A0G2JDV3-1" }, "locus": { "chromosome": "5", "start_pos": 105438886, "end_pos": 105428429, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000200045.5", "url": "https://www.ensembl.org/id/ENSMUST00000200045.5" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000142994.2", "url": "https://www.ensembl.org/id/ENSMUSP00000142994.2" } ] } }, { "isoform_ac": "A0A8Q0QEH4-1", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JDV3/entry#A0A8Q0QEH4-1", "sequence": { "sequence": "MTQPQMAPICLVENHNEQLSVNQEAIEILDKISQPVVVVAIVGLYRTGKSYLMNCLAGQNHGFPLGSTVQSQTKGIWMWCMPHPTKPEHTLVLLDTEGLGDVEKGDPKNDLWIFALSVLLSSTFIYNSMITINHQALEQLHYVTELTELIRAKSSPNPAGIKNSTEFVSFFPDFVWTVRDFMLELKLNGEDITSDDYLENALKLIPGDKPRMQASNSCRECIRLFFPNRKCFVFDRPTHDKELLQKLDSITEDQLDPKFQEVTKAFVSYIFTYAKIKTLKEGIKVTGNRLGILVTTYVNAINSGAVPCLDDAVTTLAQRENSVAVQKAADHYSEQMAQRLRLPTETLQELLDVHAACEKEAMAVFMEHSFKDENQQFLKKLVELIGENKELFLSKNEEASNKYCQEELDRLSKDFMENISTFFVPCGHKLYMDKREKIEHDYWQVPRKGVKASEVFQSFLQSQAFIESSILQADTALTAGEKAIAEERAQKVAAEKEQELLRQKQKEQQEYMEAQEKSHKENLEQLRRKLEQEREQDIKDHDMMLKKLMKDQKAFLEEGFKKKAEEMNKEIQQLRDVIKDKKRNTDRIKEALLNGFSTVLFHYLVRYLKHL", "length": 611, "header": "tr|A0A8Q0QEH4-1|A0A8Q0QEH4_MOUSE Computationally mapped isoform of Guanylate binding protein 6 OS=Mus musculus OX=10090 GN=Gbp6 PE=3 SV=1 CANONICAL=A0A0G2JDV3-1" }, "locus": { "chromosome": "5", "start_pos": 105438886, "end_pos": 105420971, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000196520.2", "url": "https://www.ensembl.org/id/ENSMUST00000196520.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000142518.2", "url": "https://www.ensembl.org/id/ENSMUSP00000142518.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "prediction_tool_list": [], "site_category": "reported_with_glycan", "site_category_dict": { "reported_with_glycan": true }, "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "37507081", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37507081" }, { "id": "A0A0G2JDV3", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A0A0G2JDV3" } ], "filter_code": "00000000000000000000.xxxxxxx.00000001000000.xxxxxxx.xxxxxxxxxx.xxxxxxxxxxxxxx.xxxxx.xxxxx" } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2007", "authors": "Degrandi D, Konermann C, Beuter-Gunia C, Kresse A, Wurthner J, Kurig S, Beer S, Pfeffer K", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JDV3", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JDV3" } ], "reference": [ { "type": "PubMed", "id": "18025219", "url": "https://glygen.org/publication/PubMed/18025219" } ] }, { "title": "Immunoproteomic discovery of novel T cell antigens from the obligate intracellular pathogen Chlamydia.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2008-02-15", "authors": "Karunakaran Karuna P, Rey-Ladino Jose, Stoynov Nikolay, Berg Kyra, Shen Caixia, Jiang Xiaozhou, Gabel Brent R, Yu Hong, Foster Leonard J, Brunham Robert C", "evidence": [ { "database": "IEDB", "id": "61982", "url": "https://www.iedb.org/epitope/61982" } ], "reference": [ { "type": "PubMed", "id": "18250455", "url": "https://glygen.org/publication/PubMed/18250455" } ] }, { "title": "A family of IFN-gamma-inducible 65-kD GTPases protects against bacterial infection.", "journal": "Science (New York, N.Y.)", "date": "2011", "authors": "Kim BH, Shenoy AR, Kumar P, Das R, Tiwari S, MacMicking JD", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JDV3", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JDV3" } ], "reference": [ { "type": "PubMed", "id": "21551061", "url": "https://glygen.org/publication/PubMed/21551061" } ] }, { "title": "Modernizing reference genome assemblies.", "journal": "PLoS Biol.", "date": "2011", "authors": "Church Deanna M, Schneider Valerie A, Graves Tina, Auger Katherine, Cunningham Fiona, Bouk Nathan, Chen Hsiu-Chuan, Agarwala Richa, McLaren William M, Ritchie Graham R S, Albracht Derek, Kremitzki Milinn, Rock Susan, Kotkiewicz Holland, Kremitzki Colin, Wollam Aye, Trani Lee, Fulton Lucinda, Fulton Robert, Matthews Lucy, Whitehead Siobhan, Chow Will, Torrance James, Dunn Matthew, Harden Glenn, Threadgold Glen, Wood Jonathan, Collins Joanna, Heath Paul, Griffiths Guy, Pelan Sarah, Grafham Darren, Eichler Evan E, Weinstock George, Mardis Elaine R, Wilson Richard K, Howe Kerstin, Flicek Paul, Hubbard Tim", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JF24", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JF24" } ], "reference": [ { "type": "PubMed", "id": "21750661", "url": "https://glygen.org/publication/PubMed/21750661" } ] }, { "title": "Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing.", "journal": "Nature", "date": "2014-11-27", "authors": "Yadav Mahesh, Jhunjhunwala Suchit, Phung Qui T, Lupardus Patrick, Tanguay Joshua, Bumbaca Stephanie, Franci Christian, Cheung Tommy K, Fritsche Jens, Weinschenk Toni, Modrusan Zora, Mellman Ira, Lill Jennie R, Delamarre L\u00e9lia", "evidence": [ { "database": "IEDB", "id": "1556573", "url": "https://www.iedb.org/epitope/1556573" }, { "database": "IEDB", "id": "116243", "url": "https://www.iedb.org/epitope/116243" }, { "database": "IEDB", "id": "148272", "url": "https://www.iedb.org/epitope/148272" }, { "database": "IEDB", "id": "61982", "url": "https://www.iedb.org/epitope/61982" }, { "database": "IEDB", "id": "918105", "url": "https://www.iedb.org/epitope/918105" } ], "reference": [ { "type": "PubMed", "id": "25428506", "url": "https://glygen.org/publication/PubMed/25428506" } ] }, { "title": "Multiplexed Relative Quantitation with Isobaric Tagging Mass Spectrometry Reveals Class I Major Histocompatibility Complex Ligand Dynamics in Response to Doxorubicin.", "journal": "Analytical chemistry", "date": "2019-04-16", "authors": "Murphy J Patrick, Yu Qijia, Konda Prathyusha, Paulo Joao A, Jedrychowski Mark P, Kowalewski Daniel J, Schuster Heiko, Kim Youra, Clements Derek, Jain Aditya, Stevanovic Stefan, Gygi Steven P, Mancias Joseph D, Gujar Shashi", "evidence": [ { "database": "IEDB", "id": "116243", "url": "https://www.iedb.org/epitope/116243" }, { "database": "IEDB", "id": "918105", "url": "https://www.iedb.org/epitope/918105" }, { "database": "IEDB", "id": "148272", "url": "https://www.iedb.org/epitope/148272" } ], "reference": [ { "type": "PubMed", "id": "30779550", "url": "https://glygen.org/publication/PubMed/30779550" } ] }, { "title": "Discordance in the Epithelial Cell-Dendritic Cell Major Histocompatibility Complex Class II Immunoproteome: Implications for Chlamydia Vaccine Development.", "journal": "The Journal of infectious diseases", "date": "2020-02-18", "authors": "Karunakaran Karuna P, Yu Hong, Jiang Xiaozhou, Chan Queenie W T, Foster Leonard J, Johnson Raymond M, Brunham Robert C", "evidence": [ { "database": "IEDB", "id": "985051", "url": "https://www.iedb.org/epitope/985051" }, { "database": "IEDB", "id": "61982", "url": "https://www.iedb.org/epitope/61982" } ], "reference": [ { "type": "PubMed", "id": "31599954", "url": "https://glygen.org/publication/PubMed/31599954" } ] }, { "title": "Differential Detection of O-GlcNAcylated proteins in the heart using antibodies.", "journal": "Analytical biochemistry", "date": "2023-10-01", "authors": "Narayanan Bhargavi, Zahra Fiddia, Reeves Russell A, Aggarwal Akanksha, O'Meally Robert N, Henry Roger K, Craven Megan, Jacobson Avital, Cole Robert N, Kohr Mark J, Umapathi Priya, Zachara Natasha E", "evidence": [ { "database": "O-GlcNAc Database", "id": "A0A0G2JDV3", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A0A0G2JDV3" } ], "reference": [ { "type": "PubMed", "id": "37507081", "url": "https://glygen.org/publication/PubMed/37507081" } ] } ], "pathway": [ { "id": "mmu:100702", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:100702", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5ZQL6-1", "protein_name": "Guanylate binding protein 6, pseudogene 2", "gene_name": "Gbp6-ps2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAPGTMKSPMCLVENKNKQLLVNPEAIHILNNISQPVVVVATVGMYRTGKSYLMNCLAGQNQGFPLGCTVQSETKGIWMWCVPHPTKPSHTLILLDTEGLGDVEKGDPRNDDWIFALAVLLSSTFVYNSMSTINHQALEKLQYPSKNQCPGYVTKLTELIRAKSSPRSDGLEDAREFLKLDGHCITEDQYLENALKLVSGIRDPQTLVSNRPRECIRQFFPRRKCFVFVWPVSDPQLLSKIESIPKSQMNPKFQEQLKNFCSYIFTHATGKRLGEGILVTGSRLGNLVQTYVDAINTGTVPCLENAVKTLAEHENSTAVQKAADHYSEQMAQRVRLPTDTLQELLDVHSACEKEAIAVFMEHSFKDDQWKFQKKLTVIVEERKGAFMEQNESASLSQCQAELDKLSASLRESITHGAFYVPGGHSLYLEAIKKVEQDYEQVPCKGVKASEVFQNFLKSQITVEESILQSDKALSDGQRAMAVELAKNEAAEKELELKRQQQKKQEQETETQMRSFSEIMTQLQKKMEMERENILRDKERVLDHKLKALRDLLLEGIEEKYEDLRREIKLRDEEIKAMKQSSIQKILDVARDILIEILPLLSDVGMKILSSYIAK", "length": 614 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-040718-32", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-040718-32#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6A3C3-1", "protein_name": "Guanylate binding protein family member 6", "gene_name": "Gbp6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAPICLVENHNERLSVNQKAIEILDKISQPVVVVAIVGLYRTGKSYLMNCLAGQNHGFPLGSTVQSQTKGIWMWCVPHPTKPKHTLVLLDTEGLGDVEKGDPKNDSWIFALAVLLSSTFVYNSLSTINHQALEQLYYVTELTKLIRARSSPNPDGIKNSTEFVSFFPDFVWTVRDFMLELTLNGKNITSDEYLENALKLIPGNSPRIQASNLPRECIRQFFPNRKCFVFDRPTHDKELLQKLETISEDQLDPNFREGTKAFVSYIFTYAKMKTLREGIKVTGNRLGTLVTTYVDAINSGAVPCLDDAVTTLAQRENSVAVQKAVDHYSEQMAQRLRLPTDTLQELLDEHTACEKEAISVFMEHSFKDENQLFLKKLVKLIGEKKGLFVLKNEEASDKYCQEELDRLSKDFMENISTFSVPGGHRLYVDMREKIERDYWQVPRKGVKASEVFQSFLQSQVIIESSILQADTALTAGEKAIAEERTQREAAEKEQELLRQKQREQQQLMEAQEKSNKENLEQLREKLVQERKQLIEEHNMMLEKQLKVGLLIPLVVLVPQVVGEGWRPGHGETP", "length": 572 }, "evidence": [ { "id": "RGD:1561523", "url": "https://alliancegenome.org/gene/RGD:1561523#orthology", "database": "AGR" }, { "id": "MGI:2140937", "url": "https://alliancegenome.org/gene/MGI:2140937#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-070912-174", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-070912-174#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-040718-32", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-040718-32#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-060531-46", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-060531-46#orthology", "database": "AGR" }, { "id": "HGNC:25395", "url": "https://alliancegenome.org/gene/HGNC:25395#orthology", "database": "AGR" }, { "id": "A0A0G2JDV3", "url": "https://omabrowser.org/oma/group/A0A0G2JDV3/", "database": "OMA" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A0A8I6GE08-1", "protein_name": "Guanylate binding protein 1", "gene_name": "Gbp1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDMTLQIHMPGPVCLIENVKGQLRANQKALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKKTGFSLGSTVQAHTKGIWMWCVPHPNKANHMLVLLDTEGLGDVEKGDNQNDCWIFSLAILLSSTFVYNSMGAINQQAMDQLHYVTELTDRIRARSSPDQDDGVEDSAEFVSFFPDFVWTLRDMTLKMEVDGLQVTADEYLEISLKLKEGSSKEVEKYNLPRLCIRKFFPKKKCFVFYPPTEWKRLSQLETLQENEIDSEFLQQVAEFCLYVFKECKAKTLPGGIIVNGPRLETLVLTYLSAISSGDLPCMENAVLTLAQIENSAAVEKAITHYDQQMSQRVQLPTETLQELLDLHRTCEREAIEIFLRVSFKDEDHSFQMKLGSRLEERWNDFCKRNMEVSSNRCWALLQDIFRPLEESVKQGTYSKPGGYYLFVQETQRLKEKYQGQPKKGLQADEVLQKYLQSKEAITTAILQTDQSLTEKEKEIEVERKKAESAQAAAKLLEETQKKNEKLMEQKERSYQEHMKQLTEKMENDRIQLKAEQERILSLKLQEQKQLLQEGFREESRKLQEEMKNVEKRYKETMDHMKAESSKTKEEMQRKYEQMLEKDRNHQEHTLHMIEKMERDRAQLVAEQEKTMTLILQERELQLRNELAEERRKHEKEIQDIVAENRQIILKLESERAESAENTIKMLTELNELNLKTLGQKQKTLEDHLIQLTEQRDKDTASLMAEQGKIFDSKLQEQEENFNKKIRAQSQQHREEIWKIKKEGFSCSLM", "length": 780 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-070912-174", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-070912-174#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-040718-32", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-040718-32#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "A4UUI3-1", "protein_name": "Guanylate-binding protein 4", "gene_name": "Gbp4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTQPQMAPICLVENHNEQLSVNQEAIEILDKISQPVVVVAIVGWSHTGKSYLMNCLAGQNHVSGTLPTSQRFPSGLHRAVSDQGHLDVVHAPPHQARALVLLDTEGLGDVEKGDPKNDLWIFALSVLLSSTFVYNSMNTINHQALEQLHYVTELTELIRAKSSPNPHGIKNSTEFVSFFPDFVWTVRDFMLELKLNGEDITSDEYLENALKLIPGNNPRIQASNSARECIRRFFPNRKCFVFEWPTHDIELIKQLETISEDQLDPTFKESAMAFASYIFTYAKIKTLREGIKVTGNGLGTLVTTYVDAINSGAVPCLDDAVTTLAQRENSVAVQKAASHYSEQMAQRLSLPTDTIQELLDVHAACEKEAMAVFMEHSFKDENQQFLKKLVELLREKNGLFLLKNEEASDKYCQEELDRLSKDLMDNISTFSVPGGHRLYMDMREKIEHDYWQVPRKGVKASEVFQNFLQSQAIIESSILQADTALTAGQKAIAEKHTKKEAAEKEQDLLRQKQKEHQEYMEAQEKRNKENLEQLRRKLEQEREQLIKDHNMMLEKLTKEQKTFREEGYKTQAEELRREIHQLGHNIKEMKQNGDSLVESILRSWFSFISPPSESEKAISSVLSLLRKKDRL", "length": 631 }, "evidence": [ { "id": "RGD:1561523", "url": "https://alliancegenome.org/gene/RGD:1561523#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-040718-32", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-040718-32#orthology", "database": "AGR" }, { "id": "HGNC:25395", "url": "https://alliancegenome.org/gene/HGNC:25395#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "B0V1H3-1", "protein_name": "Si:ch211-195h23.3", "gene_name": "si:ch211-195h23.3", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MESSQSDECMSDSEDEGECTSDSDDERGMRISLSDSDDESTSKRRFRHPRSLSMGTRSRTVKRHRFHRLQASKKTETVLEHVDGAESSSGQTPSDDAEIFTPELIQEDDKYKDKNTYRFVCPHAGQFQCSLTSLVFVMDGEGELLYRVVSWDPRLLDGLGQMQPAGPLYDVKCFNGSISKLHLPHCEIFSEGDNMDGLAVAHFTGGNMEIVQPITVTETHVMIDIRDLSLFGLLWMKIFSHPISGQVLLFLRTLPVEEEEEEEKILNVHLLPGNVPVSEVVHSHQDKKYIETTSKCHLFLEREYSLRCQPENCEVQPKSEIFEHNNFGPNFHPSFQVFLSVDVKKVGLTILDKAEDCKEVWSRPRVSLKAPSQGVEPPEHRMISGSEFVDALRGKLIQRVSSVMAIADSLRSKHMITDELYSELHNADTNQRKMRCLFMALDSGGASVKAEFYRLLKKNEPHLVEELESGHSKSFRRQ", "length": 478 }, "evidence": [ { "id": "RGD:1561523", "url": "https://alliancegenome.org/gene/RGD:1561523#orthology", "database": "AGR" }, { "id": "MGI:2140937", "url": "https://alliancegenome.org/gene/MGI:2140937#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-070912-174", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-070912-174#orthology", "database": "AGR" }, { "id": "HGNC:25395", "url": "https://alliancegenome.org/gene/HGNC:25395#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "D3ZJ56-1", "protein_name": "Guanylate binding protein 3", "gene_name": "Gbp3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MALETCMPEPMCLIENVKGQLRANQKALEILSAITQPVVVIATVGLYRTGKSYLMNKLAGRKTGFSLGSTVQSHTTGIWMWCVPHPRKADHTLVLLDTEGLGDVEKGDNQNDCWIFALAILLSSTFVYNSMGAINQQAMDQLQYVTELTDRIRTTSSPHSNGVEASAEFVSFFPDFVWTLRDVTVKLEKDGKMLTADEYLDNSLKPKQGTSEEDRNYNLPRLCIRKFFPKKKCFVFYSPTEWKKLSELESLRDDELDSEFLQQAANFCSFIFSSSKAKRLPGGIQVNGARLEKLVLTYISAISSGHLPCMENAVLALAKVENSAAIQKAITHYDQQMCQKVQLPTDTLQELLDLHRTCEREAKDIFLRTSFKDEDHSFKKDLLAQLEKKWNGINNENMNKSSTRCSELLRDIFGPLEEAVINGAYSQPGGYLLYVEKREELKKKYLQEPKKGIQAEEILQEYLQSNAAVAEALLQRDQALTVKQKEIEVERAKAESAQATVRILEEVEKKHAQMMKEKERCHQERVRQLTENMERERAQVVEEQERILNLKLQVLSCVSQLHHLLYSAESTV", "length": 572 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-070912-174", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-070912-174#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-040718-32", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-040718-32#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZQL3-1", "protein_name": "Guanylate binding protein 4", "gene_name": "Gbp4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEAPICLVQNWKEQLTVNLEAIGILEQIAQPLVVVAIVGLYRTGKSYLMNRLAGRNHGFSLGSTVQSETKGIWMWCVPHPTKPTHTLVLLDTEGLGDVEKGDPKNDSWIFALAVLLSSTFVYNSMSTINHQALEQLHYVTELTQLIRAKSDPREDKVEDSSEFVGFFPDFIWAVRDFVLELKLDGRPITEDEYLENALKLIPENNPKGQKSNMTRECIRYFFPVRKCFVFDRPTNDKSLLFQIENVPENQLEWNFQVESENFCSYIFANGKTKTLRGGVIVTGNRLGTLVQTYVDAINSGTVPCLENAVTALAQRENSAAVQKAAEHYAEQMAQRLRLPTDTLQELLEVHSACEKEAIAVFMEHSFKDDEQEFQKRLVATIEKWKEEFMLRNEAASIRHCQAELEKLSESLKESISCGAFSVPGGHSLYLEARKKVELSYEQVPRKGVKAKEVLKSFLQSQATVENSILQSDKALTDGERAVAAERTKKEVAEKERELLKQRQKEQEQVMEAQERSFQENIAKLQEKMERERVMLLREQEKMMEHKLKVQKELLVEGFRKKSDMLKNEISQLREEIERTRKKPSLFAHILDTVGNAFIMILPGAGKICGAGMKVLSSLMK", "length": 620 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-070912-174", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-070912-174#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-040718-32", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-040718-32#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-060531-46", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-060531-46#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZV82-1", "protein_name": "Guanylate binding protein 7", "gene_name": "Gbp7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASASSMEAPICLVENENEELRVNPKAINILERITQPVVVVAIVGLYRTGKSYLMNRLAGQNHGFNLGTTVRSETKGIWMWCVPHPCKPKFTLVLLDTEGLGDVEKCDPKNDSWIFALAVLLSSTFVYNSMSTINHQALEQLHYVTELTELIRTKSTPRSEEIDDSDEFVGFFPDFIWVVRDFVLELKLDGRVITADEYLENALKLIPGRSLKAQNSNLPRECIRHFFPRRKCFVFDRPIKEKELLVHVEEMPEDELDHNFREQSNVFCSYIFSNAKAKTLKEGIMVNGNRLATLVTTYVDAINSGAVPCLENAVTTLAQRENSAAVQKAAEHYSEQMAQRLRLPTDTLQELLDVHSACEKEAIAVFMEHSFKDENQEFQKNLVVTIVEKREDFSRQNEAASLSHCQAELDKLSESLRESISCGAFSVPGGHSLYLEARKKVEQDYEQVPRKGVKANHVLQSFLQSQIVIENSILQSDKALTVNQKAMEVERAQKEAAEKEQELLRQKQKELQQVMESQERSYKENIVQLHEKMETERKNILEKQEEMLAHKLKVQEEMLNEGFKRKYEAMDSEISQLQKQIQQNKEQNSSLAAQIFDGFGNVLMSVLPGTGKLFGLGLKILSRKMK", "length": 627 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-070912-174", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-070912-174#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-040718-32", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-040718-32#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "E1BAL7-1", "protein_name": "Uncharacterized protein", "gene_name": "LOC783604", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MASGSTIMDPICLVRNQNNQLTVSPRALKILEQISQPVVVVAIAGLYRTGKSYLMNRLAGRNHGFRLGSTVRSETKGIWMWCVPHPSKEKHTLVLLDTEGLGDVEKGDSSNDSWIFALAVLLSSTFVYNSMSTINHQALEQLHYVTELTELIRTKSSPSSDEEEGSAEFVSFFPDFIWTVRDFTLELELDGYPITEDEYLENALTLIPGKDPKVQNSNMPRECIRKFFPKRKCFVFDRPTNDRKLLLHVMELSDNQLDVNFQKQSEDFCSYISTHAKPKTLREGITVTGGGFGTLVEAYVDAINSGGVPCLENAVITLAERENSAAVQKAADHYSEQMTQRLNLPTDTLQELLEVHAACEKEAIDIFMERSFKDDKRMFQKKLVDIMEKTKDSFIIQNEEASVKYYEAELKQLSESLMKSISGGTFFVPGGHSLYLEAKNKFEQDYKLVPRKGVKANQVLQSFLQSQARVEEAILQADQALTDADKAMAAECAKKDAAEREQELLREKQNEEKQKMEAQERSFKENLAQLQEKMDRERENLLREQQTMLEHKLKMQKELLTEGFKKEAETLNKEIDKLKEDIQTTEKSFNISDVLDVASMILIAVLPGSYKILGMGLKYFTDRK", "length": 624 }, "evidence": [ { "id": "A0A0G2JDV3", "url": "https://omabrowser.org/oma/group/A0A0G2JDV3/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "F1M9F6-1", "protein_name": "Guanylate binding protein 5", "gene_name": "Gbp5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAPEIHMPEPICLIANTDEHLVTNQEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKEKGFSVGSTVQSHTKGIWMWCVPHPQKPDHTLVLLDTEGLGDVEKVDEKNDIQIFALAILLSSTFVYNTMSKIDQGAIDLLHSVTELTDLLRTRNTSDPSETKEPDDMSFFPDLVWTLRDFFLGLEVNGQAITSDEYLEKSLMLKQGSDERTQTFNLPRLCIQKFFPVKKCFVFDSPALGSKLSQLQTLNSDELNPDFVQNLSEFCSHIFTHSKTKTLPGGIQVNGPRLESMVQTYVDAINSGALPSMENMVVTLTRRENTAAVQKAIAHYDQQMSQKVQLPTETLQLLLDLHKTCEKEAIEIFRKRSFKDDDQCFQKELESLLSAKRDEICRKNEDASAALCSTLLQSTFQPLEQEVARGVYAKPGGHSLFLQRMEQLKAQYRQQPGKGTQAEEVLQKYLKAKEPVSATILQTDQDLTAKEKQKKEEQARAEAARAEAQRLEALRVQEEQRRVEQERRHQEHLRQIEFERANFQREQQRKQKQRVQEEMERIKAEQEAQLRALQQQLQNMRVISHHEHDQCIII", "length": 586 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-070912-174", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-070912-174#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-040718-32", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-040718-32#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P32455-1", "protein_name": "Guanylate-binding protein 1", "gene_name": "GBP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASEIHMTGPMCLIENTNGRLMANPEALKILSAITQPMVVVAIVGLYRTGKSYLMNKLAGKKKGFSLGSTVQSHTKGIWMWCVPHPKKPGHILVLLDTEGLGDVEKGDNQNDSWIFALAVLLSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSKSSPDENENEVEDSADFVSFFPDFVWTLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKFFPKKKCFVFDRPVHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIQVNGPRLESLVLTYVNAISSGDLPCMENAVLALAQIENSAAVQKAIAHYEQQMGQKVQLPTETLQELLDLHRDSEREAIEVFIRSSFKDVDHLFQKELAAQLEKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEVKAGIYSKPGGYRLFVQKLQDLKKKYYEEPRKGIQAEEILQTYLKSKESMTDAILQTDQTLTEKEKEIEVERVKAESAQASAKMLQEMQRKNEQMMEQKERSYQEHLKQLTEKMENDRVQLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEIQDLQTKMRRRKACTIS", "length": 592 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-070912-174", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-070912-174#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-040718-32", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-040718-32#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P32456-1", "protein_name": "Guanylate-binding protein 2", "gene_name": "GBP2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAPEINLPGPMSLIDNTKGQLVVNPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKKNGFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDIEKGDNENDSWIFALAILLSSTFVYNSMGTINQQAMDQLHYVTELTDRIKANSSPGNNSVDDSADFVSFFPAFVWTLRDFTLELEVDGEPITADDYLELSLKLRKGTDKKSKSFNDPRLCIRKFFPKRKCFVFDWPAPKKYLAHLEQLKEEELNPDFIEQVAEFCSYILSHSNVKTLSGGIPVNGPRLESLVLTYVNAISSGDLPCMENAVLALAQIENSAAVEKAIAHYEQQMGQKVQLPTETLQELLDLHRDSEREAIEVFMKNSFKDVDQMFQRKLGAQLEARRDDFCKQNSKASSDCCMALLQDIFGPLEEDVKQGTFSKPGGYRLFTQKLQELKNKYYQVPRKGIQAKEVLKKYLESKEDVADALLQTDQSLSEKEKAIEVERIKAESAEAAKKMLEEIQKKNEEMMEQKEKSYQEHVKQLTEKMERDRAQLMAEQEKTLALKLQEQERLLKEGFENESKRLQKDIWDIQMRSKSLEPICNIL", "length": 591 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-070912-174", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-070912-174#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-040718-32", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-040718-32#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q000W5-1", "protein_name": "Guanylate-binding protein 10", "gene_name": "Gbp10", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTQPQMAPICLVENHNEQLSVNQEAIEILDKISQPVVVVAIVGWSRTGKSYLMNCLAGQNHGFPLGSTVQSQTKGIWMWCMPHPTKPEHTLVLLDTEGLGDVEKGDPKNDLWIFALSVLLSSTFIYNSMITINHQALEQLHYVTELTELIRAKSSPNPAGIKNSTEFVSFFPDFVWIVRDFMLELKLNGEDITSDDYLENALKLIPGDKPRMQASNSCRECIRLFFPNRKCFVFDRPTHDKELLQKLDSITEDQLDPKFQEVTKAFVSYIFTYAKIKTLKEGIKVTGNKLGILVTTYVDAINSGAVPCLDDAVTTLAQRENSVAVQKAADHYSEQMAQRLRLPTETLQELLDVHAACEKEAMAVFMEHSFKDENQQFLKKLVELIGENKELFLSKNEEASNKYCQEELDRLSKDFMENISTFFVPCGHKLYMDKREKIEHDYWQVPRKGVKASEVFQSFLQSQAFIESSILQADTALTAGKKAIAEERAQKVAAEKEQDLLRQKQKEQQEYMEAQEKSHKENIEQLRRKLMQEREQLIKDHNMMLKKQLKDQKAFLEEGFKKKAEEMNKEIQQLRDVIKDKKRNTDRIKDALLNGFSTVLFHYLVRYLKHL", "length": 611 }, "evidence": [ { "id": "RGD:1561523", "url": "https://alliancegenome.org/gene/RGD:1561523#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-070912-174", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-070912-174#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-040718-32", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-040718-32#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-060531-46", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-060531-46#orthology", "database": "AGR" }, { "id": "HGNC:25395", "url": "https://alliancegenome.org/gene/HGNC:25395#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q01514-1", "protein_name": "Guanylate-binding protein 1", "gene_name": "Gbp1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASEIHMSEPMCLIENTEAQLVINQEALRILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKRTGFSLGSTVQSHTKGIWMWCVPHPKKAGQTLVLLDTEGLEDVEKGDNQNDCWIFALAVLLSSTFIYNSIGTINQQAMDQLHYVTELTDLIKSKSSPDQSDVDNSANFVGFFPIFVWTLRDFSLDLEFDGESITPDEYLETSLALRKGTDENTKKFNMPRLCIRKFFPKRKCFIFDRPGDRKQLSKLEWIQEDQLNKEFVEQVAEFTSYIFSYSGVKTLSGGITVNGPRLKSLVQTYVSAICSGELPCMENAVLTLAQIENSAAVQKAITYYEEQMNQKIHMPTETLQELLDLHRTCEREAIEVFMKNSFKDVDQKFQEELGAQLEAKRDAFVKKNMDMSSAHCSDLLEGLFAHLEEEVKQGTFYKPGGYYLFLQRKQELEKKYIQTPGKGLQAEVMLRKYFESKEDLADTLLKMDQSLTEKEKQIEMERIKAEAAEAANRALAEMQKKHEMLMEQKEQSYQEHMKQLTEKMEQERKELMAEQQRIISLKLQEQERLLKQGFQNESLQLRQEIEKIKNMPPPRSCTIL", "length": 589 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-070912-174", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-070912-174#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-040718-32", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-040718-32#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q1MT80-1", "protein_name": "Guanylate-binding protein 4", "gene_name": "gbp4", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MDKPVCLIDTGSDGKLCVQQAALQVLQQIQQPVVVVAVVGLYRTGKSFLMNRLAGKRTGFALSSNIKPKTEGIWMWCMPHPTKAGTTLVLLDTEGLEDVEKGDSKRDTYIFSLAVLLSSTLVYNSRGVIDNKAMEELQYVTELIEHIKVTPDEDADDCTAFAKFFPHFIWCLRDFTLELKLDGKDLTEDEYLEFALKLRPGTSKKVMMYNLPRECIRKFFPCRTCFTFPSPTTPEKRSILESLSPAELDPEFLEVTKRFCKFVFDRSEVKQLKGGHTVTGRVLGNLTKMYVDTISSGAVFCLENAVIAMAQIENEAATQEGLEVYQRGMEKLKSSFPLELEQVSSEHQRLSSMATQAFMARSFKDTDGKHLKALEGEMGKLFDAYRSQNKQVGLETHCDLLLYMRCKDPLILHVYFFPVNDARSKEKVEQNERSSLPISHPRPDRPFQVKTPHVLEVPGASVYPEEGISFRTDVEPNFFKVRKLQVDDVQMNLVRQKDKMSVWTTTIWKEEFVHLQQVRDERKLNSEIEKNDFFNAHRVAFIERVTNVKSIADKLHGQRIIHKELYSEITQTNVTRQQIMRKICDSVDSSGRIAKCKFIDILQEEERCLLEDLKQSES", "length": 618 }, "evidence": [ { "id": "RGD:1561523", "url": "https://alliancegenome.org/gene/RGD:1561523#orthology", "database": "AGR" }, { "id": "MGI:2140937", "url": "https://alliancegenome.org/gene/MGI:2140937#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-060531-46", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-060531-46#orthology", "database": "AGR" }, { "id": "HGNC:25395", "url": "https://alliancegenome.org/gene/HGNC:25395#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q2V6D6-1", "protein_name": "Guanylate-binding protein 8", "gene_name": "Gbp8", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTQPQMAPICLVENHNEHLSVNHEAIEILEKISQPVVVVAIVGLYRTGKSYLMNRLAGQNHGFPLGSTVQSQTKGIWMWCMPHPTKPEHTLVLLDTEGLGDVEKGDPKNDLWIFALSVLLSSTFIYNSMNTISHDSLEKLHYVTELTELIRAKSSPNPDGIKNSTEFVSFFPDFVWTVRDFMLELKLNGEDITSDEYLENALKLIPGLGILVTTYVDAINSGAVPCVDDAVTTLAQRENSVAVQRAADHYSEQMVQRLSLPTDTLQELLDVHAACEKEAMAVFMEHSFKDENQQFLKKLVELIGEAKVLFLLKNEEASDKYCQEELDRLSKDLMDNISTFSVPGGHRLYMDMREKIEHDYWQVPRKGVKAREVFQSFLQSQAIIESSILQADTALTAGQKAIAEERTKKEAAEKEQDLLRQKQKEQQEYMEAQEKRNKENIEQLRRKLEQEREQLIKDHNMMVEKKLKEQKALLEEGFKKKAEEMDGEIQQLKHNIEDMKKKQWFHFRYYYKRSCFIYFFSHFND", "length": 525 }, "evidence": [ { "id": "RGD:1561523", "url": "https://alliancegenome.org/gene/RGD:1561523#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-040718-32", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-040718-32#orthology", "database": "AGR" }, { "id": "HGNC:25395", "url": "https://alliancegenome.org/gene/HGNC:25395#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q61107-1", "protein_name": "Guanylate-binding protein 3", "gene_name": "Gbp3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEAPICLVENWKNQLTVNLEAIRILEQIAQPLVVVAIVGLYRTGKSYLMNRLAGRNHGFSLGSTVQSETKGIWMWCVPHPTKPTHTLVLLDTEGLGDVEKGDPKNDSWIFALAVLLSSTFVYNSMSTINQQALEQLHFVTELTQLIRAKSSPREDKVKDSSEFVGFFPDFIWAVRDFALELKLNGRPITEDEYLENALKLIQGDNLKVQQSNMTRECIRYFFPVRKCFVFDRPTSDKRLLLQIENVPENQLERNFQVESEKFCSYIFTNGKTKTLRGGVIVTGNRLGTLVQTYVNAINSGTVPCLENAVTTLAQRENSIAVQKAADHYSEQMAQRMRLPTDTLQELLTVHAACEKEAIAVFMEHSFKDDEQEFQKKLVVTIEERKEEFIRQNEAASIRHCQAELERLSESLRKSISCGAFSVPGGHSLYLEARKKIELGYQQVLRKGVKAKEVLKSFLQSQAIMEDSILQSDKALTDGERAIAAERTKKEVAEKELELLRQRQKEQEQVMEAQERSFRENIAKLQEKMESEKEMLLREQEKMLEHKLKVQEELLIEGFREKSDMLKNEISHLREEMERTRRKPSLFGQILDTIGNAFIMILPGAGKLFGVGLKFLGSLSS", "length": 620 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-070912-174", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-070912-174#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-040718-32", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-040718-32#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q63663-1", "protein_name": "Guanylate-binding protein 2", "gene_name": "Gbp2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASEIHMLQPMCLIENTEAHLVINQEALRILSAINQPVVVVAIVGLYRTGKSYLMNKLAGKRTGFSLGSTVQSHTKGIWMWCVPHPKKAGQTLVLLDTEGLEDVEKGDNQNDCWIFALAVLLSSTFVYNSMGTINQQAMDQLHYVTELTDLIKSKSSPDQSGIDDSANFVGFFPTFVWALRDFSLELEVNGKLVTPDEYLEHSLTLKKGADKKTKSFNEPRLCIRKFFPKRKCFIFDRPALRKQLCKLETLGEEELCSEFVEQVAEFTSYIFSYSAVKTLSGGIIVNGPRLKSLVQTYVGAISSGSLPCMESAVLTLAQIENSAAVQKAITHYEEQMNQKIQMPTETLQELLDLHRLIEREAIEIFLKNSFKDVDQKFQTELGNLLISKRDAFIKKNSDVSSAHCSDLIEDIFGPLEEEVKQGTFSKPGGYFLFLQMRQELEKKYNQAPGKGLEAEAVLKKYFESKEDIVETLLKTDQSLTEAAKEIEVERIKAETAEAANRELAEKQEKFELMMQQKEESYQEHVRQLTEKMKEEQKKLIEEQDNIIALKLREQEKFLREGYENESKKLLREIENMKRRQSPGKCTIL", "length": 589 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-070912-174", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-070912-174#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-040718-32", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-040718-32#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6DHP7-1", "protein_name": "Zgc:92185", "gene_name": "gbp1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSKPTMMPSPICLVENVNGSLSICKDAIDFLSNINEPVVVVSVVGLYRTGKSYLMNRLAGQQTGFALGNTIESKTKGIWMWCVPHPKKQGHTLVLLDTEGLGDVDKGDSKNDGWIFCLAVLLSSTLVYNSRGTIDNSALEKLHYITELTEQIKIRTAEAADEEDEEDSKFVLFFPSFTWVVRDFTLDLVIDGKNVNEDQYLDFALQLRKGNNKKALEYNLPRQCIRNYFPSRKCFVFPSPASPEKMKQLESLQEKDLVPDFLEVTGRFCEHIFRNSVVKTLKGGHKVTGKLLGHLAKIYVDTISSGKVPCLDNAVVALANLENKCAVEEAFKVYERGMEEVKKTFPVNVDEISSEHQRFSSLANAEFMKRSFKDEKQEYINQLKEKIDVYYGCLLEDNGLASKKKCEDLLKDLFSEMNKKLQDGVYSQPGGYELYCKDRDVIVEKYRREPNKGVLAEAVLHEFLNERGAEANSILYTDTKLTENDKKIQEEKERNALMQQKCEEEQEKRIESERMMAAEKVRQDDQIKQMQEKFEKEREQMQQETEKAIDSKLKEQEEMLNKGFKERADLLSEEINDLKKEKKGFMEEYIMPIVGAAAQILPTILDYRVMMKGMKYGKVKI", "length": 621 }, "evidence": [ { "id": "RGD:1561523", "url": "https://alliancegenome.org/gene/RGD:1561523#orthology", "database": "AGR" }, { "id": "MGI:2140937", "url": "https://alliancegenome.org/gene/MGI:2140937#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-040718-32", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-040718-32#orthology", "database": "AGR" }, { "id": "HGNC:25395", "url": "https://alliancegenome.org/gene/HGNC:25395#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q6ZN66-1", "protein_name": "Guanylate-binding protein 6", "gene_name": "GBP6", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MESGPKMLAPVCLVENNNEQLLVNQQAIQILEKISQPVVVVAIVGLYRTGKSYLMNHLAGQNHGFPLGSTVQSETKGIWMWCVPHPSKPNHTLVLLDTEGLGDVEKGDPKNDSWIFALAVLLCSTFVYNSMSTINHQALEQLHYVTELTELIKAKSSPRPDGVEDSTEFVSFFPDFLWTVRDFTLELKLNGHPITEDEYLENALKLIQGNNPRVQTSNFPRECIRRFFPKRKCFVFDRPTNDKDLLANIEKVSEKQLDPKFQEQTNIFCSYIFTHARTKTLREGITVTGNRLGTLAVTYVEAINSGAVPCLENAVITLAQRENSAAVQRAADYYSQQMAQRVKLPTDTLQELLDMHAACEREAIAIFMEHSFKDENQEFQKKFMETTMNKKGDFLLQNEESSVQYCQAKLNELSKGLMESISAGSFSVPGGHKLYMETKERIEQDYWQVPRKGVKAKEVFQRFLESQMVIEESILQSDKALTDREKAVAVDRAKKEAAEKEQELLKQKLQEQQQQMEAQDKSRKENIAQLKEKLQMEREHLLREQIMMLEHTQKVQNDWLHEGFKKKYEEMNAEISQFKRMIDTTKNDDTPWIARTLDNLADELTAILSAPAKLIGHGVKGVSSLFKKHKLPF", "length": 633 }, "evidence": [ { "id": "RGD:1561523", "url": "https://alliancegenome.org/gene/RGD:1561523#orthology", "database": "AGR" }, { "id": "MGI:2140937", "url": "https://alliancegenome.org/gene/MGI:2140937#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-070912-174", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-070912-174#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-040718-32", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-040718-32#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-060531-46", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-060531-46#orthology", "database": "AGR" }, { "id": "HGNC:25395", "url": "https://alliancegenome.org/gene/HGNC:25395#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BTS3-1", "protein_name": "Guanylate-binding protein 9", "gene_name": "Gbp9", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTQPQMAPICLVENHNEQLLVNQEAIEILEKISQPVVVVAIVGLYRTGKSYLMNCLAGQNHGFPLGSTVQSQTKGIWMWCMPHPTKPEHTLVLLDTEGLGDVEKSNPKNDSWIFALSVLLSSTFVYNSMSTINHQALEQLHYVTELTELIRSKSSRNPHGIKNSTEFVSFFPDFVWTVRDFMLELKLNGEDITSDEYLENALKLIPGYNPRVQASNSARECIRCFFPNRKCFVFDRPTHDRELLQKLETISEDQLDLKFREGTKAFVSYVFTYAKIKTLREGIKVTGNRLGTLVTTYVDAINSGAVPCLDDAMTSVARRENSVAVQKAADHYSEQMAQRLRLPTDTLQELLDVHAACEKEAMAVFMEHSFKDENQQFLKKLVEIISEKIAFFWLKNEEASNKYCQEELDRLSKDFMDNISTFSVPGGHRIYTDMRKKIERDYWQVPRKGVKACEVFQNFLQSQYIIESSILQADRALTAGEKAIAEERAQKEVAEKEQELLRQKQKEQQEYMEAQEKRNKENLEQLRRKLMQEREQDIKDHDMMLEKQLKDQKAFLEEGFTNKAEEINAEIERLEHNIKDKKENIGPILELIEKAFCAGVFSSLIMVALLTHNPSLLRK", "length": 619 }, "evidence": [ { "id": "RGD:1561523", "url": "https://alliancegenome.org/gene/RGD:1561523#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-070912-174", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-070912-174#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-040718-32", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-040718-32#orthology", "database": "AGR" }, { "id": "HGNC:25395", "url": "https://alliancegenome.org/gene/HGNC:25395#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8CFB4-1", "protein_name": "Guanylate-binding protein 5", "gene_name": "Gbp5", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAPEIHMPEPLCLIGSTEGHLVTNQEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKEKGFSVGSTVQSHTKGIWMWCVPHPQKPDHTLVLLDTEGLGDVEKDDKKNDTQIFALAILLSSTFVYNTMNKIDQGAIDLLHNVTELTDLLRTRNSSDSNQTEGEGPADMSFFPDLVWTLRDFFLDLQANGHAITSDEYLENSLKLKQGSDERTQTFNLPRLCIQKFFPVKKCFVFDAPALGSKLSQLPTLSNEELNSDFVQDLSEFCSHIFTQSKTKTLPGGIQVNGPRLESLVLTYVDAINSGALPSIENTVVTLARRENSAAVQKAIGHYDQLMSEKVQLPTETLQELLDLHRTCEREAIEIFRKHSFKDEGEFFQKELESLLSAKQDEICKKNADASAALCSTLLGSIFKPLEQEVAQEFYHKPGGHKLFLQRMEQLKANYRQQPGKGTQAEEVLQTYLNAKETVSRTILQTDQVLTDKEIQSKAEQERAEAARLEAQRLEAIRIQEEQRKAEMERQHQEQLRQIALEKARVAQEQQWILKQRAQEEADRIKAEQEAQLRALQQQLQHMREMNHHRRHHHDCVIS", "length": 590 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-040718-32", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-040718-32#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8N8V2-1", "protein_name": "Guanylate-binding protein 7", "gene_name": "GBP7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASEIHMPGPVCLTENTKGHLVVNSEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKNKGFPLGCTVKSETKGIWMWCVPHPSKPNHTLILLDTEGLGDMEKSDPKSDSWIFALAVLLSSSFVYNSMGTINHQALEQLHYVTELTELIRAKSCPRPDEVEDSSEFVSFFPDFIWTVRDFTLELKLDGHPITEDEYLENALKLISGKNPQIQNSNKPREWIRHFFPKQKCFVFDRPINDKKLLLHVEEVREDQLDSNFQMQSENFCSYIFTHAKTKTLREGILVTGNRLGMLVETYLDAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTESISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERENYMRELRKMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQILDVAGSIFIAALPGAAKLVDLGMKILSSLCNRLRNPGKKIIS", "length": 638 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-070912-174", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-070912-174#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-040718-32", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-040718-32#orthology", "database": "AGR" }, { "id": "A0A0G2JDV3", "url": "https://omabrowser.org/oma/group/A0A0G2JDV3/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q91Z40-1", "protein_name": "Guanylate-binding protein 7", "gene_name": "Gbp7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASGPNMEAPVCLVENENEELRVNSKAINILERITQPVVVVAIVGLYRTGKSYLMNRLAGQNHGFNLGTTVRSETKGIWMWCVPHPSKPKFTLVLLDTEGLGDVEKGDPKNDSWIFALAVLLSSTFVYNSMSTINHQALEQLHYVTELTERIRAKSTSRSEEVDDSDEFVSFFPDFIWTVRDFVLELKLEGRVITADEYLENALKLIPGMSIKAQKANLPRECIRHFFPRRKCFVFDRPTKDKELLVHVEEMPEDQLDHSFQVQSKEFCSYIFSNSKAKTLKEGIVVNGNRLATLVTTYVDAINSGDVPCLENAVTTLAQRENSIAVQKAADHYSEQMAQRMRLPTDTLQELLTVHTACEKEAIAVFMEHSFKDENQQFQKNLVVTIEEKKEDFLRQNEAASLSHCQAELDKLSESLRESISRGVFSVPGGHRLYLEARKKVEQDYERVPRKGVKANHVLQSFLQSQISIEDSIMQSDKALTDGQKAMEAERAQKEAAEKEQELLRQKQKELQQVMEAQERSYKENVAQLHEKMETERKNILREQEVKLEHKLKIQKDMLNEGFKRKCEAMDLEISQLQKEIQLNKEKNSSLGAKILDGFGDVLISVVPGSGKYFGLGLKILSSQMNQTQNSDKVRKL", "length": 638 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-070912-174", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-070912-174#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-040718-32", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-040718-32#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96PP8-1", "protein_name": "Guanylate-binding protein 5", "gene_name": "GBP5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MALEIHMSDPMCLIENFNEQLKVNQEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKNKGFSVASTVQSHTKGIWIWCVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALALLLSSTFVYNTVNKIDQGAIDLLHNVTELTDLLKARNSPDLDRVEDPADSASFFPDLVWTLRDFCLGLEIDGQLVTPDEYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDLPAHQKKLAQLETLPDDELEPEFVQQVTEFCSYIFSHSMTKTLPGGIMVNGSRLKNLVLTYVNAISSGDLPCIENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQMEIAKQNWLAEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTVNNDDPCVLL", "length": 586 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-070912-174", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-070912-174#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-040718-32", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-040718-32#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q96PP9-1", "protein_name": "Guanylate-binding protein 4", "gene_name": "GBP4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGERTLHAAVPTPGYPESESIMMAPICLVENQEEQLTVNSKALEILDKISQPVVVVAIVGLYRTGKSYLMNRLAGKRNGFPLGSTVQSETKGIWMWCVPHLSKPNHTLVLLDTEGLGDVEKSNPKNDSWIFALAVLLSSSFVYNSVSTINHQALEQLHYVTELAELIRAKSCPRPDEAEDSSEFASFFPDFIWTVRDFTLELKLDGNPITEDEYLENALKLIPGKNPKIQNSNMPRECIRHFFRKRKCFVFDRPTNDKQYLNHMDEVPEENLERHFLMQSDNFCSYIFTHAKTKTLREGIIVTGKRLGTLVVTYVDAINSGAVPCLENAVTALAQLENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACEREAIAVFMEHSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAKYCQAELKRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIAAERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEERENLLREHERLLKHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIESTKNEQLRLLKILDMASNIMIVTLPGASKLLGVGTKYLGSRI", "length": 640 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-070912-174", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-070912-174#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-040718-32", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-040718-32#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9H0R5-1", "protein_name": "Guanylate-binding protein 3", "gene_name": "GBP3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAPEIHMTGPMCLIENTNGELVANPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKNKGFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDVKKGDNQNDSWIFTLAVLLSSTLVYNSMGTINQQAMDQLYYVTELTHRIRSKSSPDENENEDSADFVSFFPDFVWTLRDFSLDLEADGQPLTPDEYLEYSLKLTQGTSQKDKNFNLPRLCIRKFFPKKKCFVFDLPIHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIKVNGPRLESLVLTYINAISRGDLPCMENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSEREATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEVKAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQEQARVLKERCQGESTQLQNEIQKLQKTLKKKTKRYMSHKLKI", "length": 595 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-070912-174", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-070912-174#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-040718-32", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-040718-32#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9Z0E6-1", "protein_name": "Guanylate-binding protein 2", "gene_name": "Gbp2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASEIHMSEPMCLIENTEAQLVINQEALRILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKRTGFSLGSTVQSHTKGIWMWCVPHPKKAGQTLVLLDTEGLEDVEKGDNQNDCWIFALAVLLSSTFIYNSIGTINQQAMDQLHYVTELTDLIKSKSSPDQSGVDDSANFVGFFPTFVWTLRDFSLELEVNGKPVTSDEYLEHSLTLKKGADKKTKSFNEPRLCIRKFFPKRKCFIFDRPAQRKQLSKLETLREEELCGEFVEQVAEFTSYILSYSSVKTLCGGIIVNGPRLKSLVQTYVGAISNGSLPCMESAVLTLAQIENSAAVQKAITHYEEQMNQKIQMPTETLQELLDLHRPIESEAIEVFLKNSFKDVDQKFQTELGNLLVAKRDAFIKKNMDVSSARCSDLLEDIFGPLEEEVKLGTFSKPGGYYLFLQMRQELEKKYNQAPGKGLQAEAMLKNYFDSKADVVETLLQTDQSLTEAAKEVEEERTKAEAAEAANRELEKKQKEFELMMQQKEKSYQEHVKKLTEKMKDEQKQLLAEQENIIAAKLREQEKFLKEGFENESKKLIREIDTLKQNKSSGKCTIL", "length": 589 }, "evidence": [ { "id": "ZFIN:ZDB-GENE-070912-174", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-070912-174#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-040718-32", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-040718-32#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JDV3", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JDV3" } ], "pmid": "" }, { "name": "GTP binding", "id": "GO:0005525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JDV3", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JDV3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "cellular response to type II interferon", "id": "GO:0071346", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071346", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JDV3", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JDV3" } ], "pmid": "" }, { "name": "adhesion of symbiont to host", "id": "GO:0044406", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044406", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JDV3", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JDV3" } ], "pmid": "" }, { "name": "defense response to Gram-positive bacterium", "id": "GO:0050830", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050830", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JDV3", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JDV3" } ], "pmid": "" }, { "name": "response to bacterium", "id": "GO:0009617", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009617", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JDV3", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JDV3" } ], "pmid": "" }, { "name": "cellular response to lipopolysaccharide", "id": "GO:0071222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071222", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JDV3", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JDV3" } ], "pmid": "" }, { "name": "cellular response to interferon-beta", "id": "GO:0035458", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035458", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JDV3", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JDV3" } ], "pmid": "" }, { "name": "defense response to protozoan", "id": "GO:0042832", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042832", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JDV3", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JDV3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JDV3", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JDV3" } ], "pmid": "" }, { "name": "symbiont-containing vacuole membrane", "id": "GO:0020005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020005", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2JDV3", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JDV3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 163, "end_pos": 165, "annotation": "n_glycosylation_sequon" }, { "start_pos": 418, "end_pos": 420, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "19669", "name": "", "equation": "GTP + H2O = GDP + phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61021-1", "Q62293-1", "Q61107-1", "P60766-2", "Q8BZ98-1", "Q8CFB4-1", "Q8C3X4-1", "P32233-1", "Q9Z0E6-1", "Q9QXB9-1", "Q01514-1", "Q8K1M6-12", "P39053-1", "P39054-1", "Q8C262-1", "Q8C7H1-1", "Q5S006-1", "Q80U63-1", "Q811U4-1", "Q05D44-1", "Q9QZ85-1", "P58281-1", "Q99P58-1", "Q9QUI0-1", "Q9ERI2-1", "P63001-1", "Q9CQD1-1", "Q3T9E4-1", "Q7TQD2-1", "P56371-1", "P62821-1", "Q91ZR1-1", "P35278-1", "P46638-1", "Q3TCT4-1", "Q9CQW2-1", "Q9D1G1-1", "P51150-1", "P62492-1", "Q7TT45-1", "P61226-1", "P61027-1", "Q99JI6-1", "Q8R367-1", "Q922H7-1", "Q8BU31-1", "Q80ZJ1-1", "Q80X95-1", "P70426-1", "Q8K5A4-1", "P70425-1", "Q61411-1", "Q5SSG5-1", "Q6NTA4-1", "Q99K70-1", "Q9JIW9-1", "Q08AT1-1", "O08989-1", "P60764-1", "P62835-1", "P63321-1", "Q6IMB1-1", "P32883-1", "Q9Z0N2-1", "Q9Z0N1-1", "P08556-1", "Q7TN89-1", "A4UUI3-1", "Q8VEH6-1", "A0A0G2JDV3-1", "Q91Z40-1", "P68368-1", "P62331-1", "Q60766-1", "A0A140LIF8-1", "Q9DCE9-1", "Q3UX10-1", "Q9JJZ2-1", "Q0GUM3-1", "E9PXC0-1", "P53994-1", "P59279-1", "P62827-1", "P55258-1", "P61294-1", "Q61820-1", "P84078-1", "Q9CQA9-1", "P68369-1", "Q69ZS7-1", "P05214-1", "P05213-1", "P68373-1", "Q64008-1", "Q9R0M6-1", "Q8BHH2-1", "Q9WTL2-1", "Q149F3-1", "Q8R050-1", "Q05144-1", "Q9JKM7-1", "Q8BFR5-1", "Q8C0D5-1", "Q8K0D5-1", "P18872-1", "Q8K386-1", "Q923K4-1", "P35294-1", "P35279-1", "P62631-1", "P62823-1", "P61028-1", "Q504M8-1", "Q8CAM5-1", "Q921E2-1", "P35276-1", "P35292-1", "P63011-1", "P35283-1", "P35288-1", "P35293-1", "Q8QZZ8-1", "Q6PHN9-1", "Q9CZE3-1", "Q9DD03-1", "Q9CZT8-1", "Q921J2-1", "P14576-1", "P55772-1", "Q8R2Q4-1", "P10126-1", "P61222-1", "P58252-1", "B2RVE2-1", "Q9JHW4-1", "Q5PR73-1", "Q91V41-1", "P36536-1", "Q9CQC9-1", "P10833-1", "P35282-1", "P35290-1", "Q8CGK7-1", "P21279-1", "Q6R0H7-1", "B2RSH2-1", "Q6PA06-1", "Q9D8T3-1", "Q3UP38-2", "Q91YH5-1", "P35295-1", "P97950-1", "P62071-1", "Q8BH66-1", "Q8BG51-1", "Q8BHC1-1", "Q8BHD0-1", "Q923S9-1", "Q99KL7-1", "Q3UM18-1", "Q8VHP8-1", "Q8VHQ4-1", "O35963-1", "Q8JZN7-1", "Q9ER88-1", "Q0PD08-1" ], "evidence": [ { "id": "19669", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19669" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A0G2JDV3", "gene_name": "Gbp6", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A0A0G2JDV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A0G2JDV3" } ] } ] }, { "uniprot_ac": "A0A140LIF8", "gene_name": "Irgm2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A0A140LIF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A140LIF8" } ] } ] }, { "uniprot_ac": "A4UUI3", "gene_name": "Gbp4", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A4UUI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A4UUI3" } ] } ] }, { "uniprot_ac": "B2RSH2", "gene_name": "Gnai1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "B2RSH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/B2RSH2" } ] } ] }, { "uniprot_ac": "B2RVE2", "gene_name": "Rergl", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "B2RVE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/B2RVE2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "B2RVE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/B2RVE2" } ] } ] }, { "uniprot_ac": "E9PXC0", "gene_name": "Srp54c", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "E9PXC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/E9PXC0" } ] } ] }, { "uniprot_ac": "O08989", "gene_name": "Mras", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "O08989", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O08989" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "O08989", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O08989" } ] } ] }, { "uniprot_ac": "O35963", "gene_name": "Rab33b", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "O35963", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O35963" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "O35963", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/O35963" } ] } ] }, { "uniprot_ac": "P05213", "gene_name": "Tuba1b", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P05213", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05213" } ] } ] }, { "uniprot_ac": "P05214", "gene_name": "Tuba3a", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P05214", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P05214" } ] } ] }, { "uniprot_ac": "P08556", "gene_name": "Nras", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P08556", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P08556" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P08556", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P08556" } ] } ] }, { "uniprot_ac": "P10126", "gene_name": "Eef1a1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P10126", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10126" } ] } ] }, { "uniprot_ac": "P10833", "gene_name": "Rras", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P10833", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10833" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P10833", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P10833" } ] } ] }, { "uniprot_ac": "P14576", "gene_name": "Srp54", "activity": [ { "ec_number": "3.6.5.4", "activity": "GTP + H2O = GDP + phosphate + H(+).", "evidence": [ { "id": "P14576", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P14576" } ] }, { "ec_number": "3.6.5.4", "activity": "", "evidence": [ { "id": "P14576", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P14576" } ] } ] }, { "uniprot_ac": "P18872", "gene_name": "Gnao1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { 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