{ "uniprot_canonical_ac": "A0A0F7C9F3-1", "uniprot_ac": "A0A0F7C9F3", "uniprot_id": "A0A0F7C9F3_DANRE", "mass": { "chemical_mass": 188531.0, "monoisotopic_mass": 188531.0 }, "refseq": { "ac": "NP_001295895", "name": "ras GTPase-activating-like protein IQGAP1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001295895" }, "gene_names": [ { "name": "iqgap1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0F7C9F3", "id": "A0A0F7C9F3" }, { "name": "IQGAP1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0F7C9F3", "id": "A0A0F7C9F3" }, { "name": "im:7152854; im:7156663", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001295895", "id": "NP_001295895" }, { "name": "im:7152854", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0F7C9F3", "id": "A0A0F7C9F3" }, { "name": "im:7156663", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0F7C9F3", "id": "A0A0F7C9F3" }, { "name": "iqgap1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001295895", "id": "NP_001295895" } ], "protein_names": [ { "name": "IQGAP1 protein", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0F7C9F3/entry#names_and_taxonomy", "id": "A0A0F7C9F3" }, { "name": "Ras GTPase-activating-like protein IQGAP1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A0F7C9F3/entry#names_and_taxonomy", "id": "A0A0F7C9F3" }, { "name": "ras GTPase-activating-like protein IQGAP1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001295895", "id": "NP_001295895" } ], "function": [ { "annotation": "##Evidence-Data-START## Transcript exon combination :: KP862587.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from KP862587.1. 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J.", "date": "2009", "authors": "Shi Xianke, Foo Yong Hwee, Sudhaharan Thankiah, Chong Shang-Wei, Korzh Vladimir, Ahmed Sohail, Wohland Thorsten", "evidence": [ { "database": "UniProtKB", "id": "A0A0F7C9F3", "url": "https://www.uniprot.org/uniprotkb/A0A0F7C9F3" } ], "reference": [ { "type": "PubMed", "id": "19619483", "url": "https://glygen.org/publication/PubMed/19619483" } ] }, { "title": "The zebrafish reference genome sequence and its relationship to the human genome.", "journal": "Nature", "date": "2013", "authors": "Howe Kerstin, Clark Matthew D, Torroja Carlos F, Torrance James, Berthelot Camille, Muffato Matthieu, Collins John E, Humphray Sean, McLaren Karen, Matthews Lucy, McLaren Stuart, Sealy Ian, Caccamo Mario, Churcher Carol, Scott Carol, Barrett Jeffrey C, Koch Romke, Rauch Gerd-J\u00f6rg, White Simon, Chow William, Kilian Britt, Quintais Leonor T, Guerra-Assun\u00e7\u00e3o Jos\u00e9 A, Zhou Yi, Gu Yong, Yen Jennifer, Vogel Jan-Hinnerk, Eyre Tina, Redmond Seth, Banerjee Ruby, Chi Jianxiang, Fu Beiyuan, Langley Elizabeth, Maguire Sean F, Laird Gavin K, Lloyd David, Kenyon Emma, Donaldson Sarah, Sehra Harminder, Almeida-King Jeff, Loveland Jane, Trevanion Stephen, Jones Matt, Quail Mike, Willey Dave, Hunt Adrienne, Burton John, Sims Sarah, McLay Kirsten, Plumb Bob, Davis Joy, Clee Chris, Oliver Karen, Clark Richard, Riddle Clare, Elliot David, Eliott David, Threadgold Glen, Harden Glenn, Ware Darren, Begum Sharmin, Mortimore Beverley, Mortimer Beverly, Kerry Giselle, Heath Paul, Phillimore Benjamin, Tracey Alan, Corby Nicole, Dunn Matthew, Johnson Christopher, Wood Jonathan, Clark Susan, Pelan Sarah, Griffiths Guy, Smith Michelle, Glithero Rebecca, Howden Philip, Barker Nicholas, Lloyd Christine, Stevens Christopher, Harley Joanna, Holt Karen, Panagiotidis Georgios, Lovell Jamieson, Beasley Helen, Henderson Carl, Gordon Daria, Auger Katherine, Wright Deborah, Collins Joanna, Raisen Claire, Dyer Lauren, Leung Kenric, Robertson Lauren, Ambridge Kirsty, Leongamornlert Daniel, McGuire Sarah, Gilderthorp Ruth, Griffiths Coline, Manthravadi Deepa, Nichol Sarah, Barker Gary, Whitehead Siobhan, Kay Michael, Brown Jacqueline, Murnane Clare, Gray Emma, Humphries Matthew, Sycamore Neil, Barker Darren, Saunders David, Wallis Justene, Babbage Anne, Hammond Sian, Mashreghi-Mohammadi Maryam, Barr Lucy, Martin Sancha, Wray Paul, Ellington Andrew, Matthews Nicholas, Ellwood Matthew, Woodmansey Rebecca, Clark Graham, Cooper James D, Cooper James, Tromans Anthony, Grafham Darren, Skuce Carl, Pandian Richard, Andrews Robert, Harrison Elliot, Kimberley Andrew, Garnett Jane, Fosker Nigel, Hall Rebekah, Garner Patrick, Kelly Daniel, Bird Christine, Palmer Sophie, Gehring Ines, Berger Andrea, Dooley Christopher M, Ersan-\u00dcr\u00fcn Z\u00fcbeyde, Eser Cigdem, Geiger Horst, Geisler Maria, Karotki Lena, Kirn Anette, Konantz Judith, Konantz Martina, Oberl\u00e4nder Martina, Rudolph-Geiger Silke, Teucke Mathias, Lanz Christa, Raddatz G\u00fcnter, Osoegawa Kazutoyo, Zhu Baoli, Rapp Amanda, Widaa Sara, Langford Cordelia, Yang Fengtang, Schuster Stephan C, Carter Nigel P, Harrow Jennifer, Ning Zemin, Herrero Javier, Searle Steve M J, Enright Anton, Geisler Robert, Plasterk Ronald H A, Lee Charles, Westerfield Monte, de Jong Pieter J, Zon Leonard I, Postlethwait John H, N\u00fcsslein-Volhard Christiane, Hubbard Tim J P, Roest Crollius Hugues, Rogers Jane, Stemple Derek L", "evidence": [ { "database": "UniProtKB", "id": "A0A0F7C9F3", "url": "https://www.uniprot.org/uniprotkb/A0A0F7C9F3" } ], "reference": [ { "type": "PubMed", "id": "23594743", "url": "https://glygen.org/publication/PubMed/23594743" } ] }, { "title": "Dynamics of zebrafish fin regeneration using a pulsed SILAC approach.", "journal": "Proteomics", "date": "2015", "authors": "Nolte Hendrik, H\u00f6lper Soraya, Housley Michael P, Islam Shariful, Piller Tanja, Konzer Anne, Stainier Didier Y R, Braun Thomas, Kr\u00fcger Marcus", "evidence": [ { "database": "UniProtKB", "id": "A0A0F7C9F3", "url": "https://www.uniprot.org/uniprotkb/A0A0F7C9F3" } ], "reference": [ { "type": "PubMed", "id": "25504979", "url": "https://glygen.org/publication/PubMed/25504979" } ] }, { "title": "IQGAP3 is essential for cell proliferation and motility during zebrafish embryonic development.", "journal": "Cytoskeleton", "date": "2015", "authors": "Fang Xiaolan, Zhang Bianhong, Thisse Bernard, Bloom George S, Thisse Christine", "evidence": [ { "database": "UniProtKB", "id": "A0A0F7C9F3", "url": "https://www.uniprot.org/uniprotkb/A0A0F7C9F3" } ], "reference": [ { "type": "PubMed", "id": "26286209", "url": "https://glygen.org/publication/PubMed/26286209" } ] }, { "title": "RFX transcription factors are essential for hearing in mice.", "journal": "Nat. Commun.", "date": "2015", "authors": "Elkon Ran, Milon Beatrice, Morrison Laura, Shah Manan, Vijayakumar Sarath, Racherla Manoj, Leitch Carmen C, Silipino Lorna, Hadi Shadan, Weiss-Gayet Mich\u00e8le, Barras Emmanu\u00e8le, Schmid Christoph D, Ait-Lounis Aouatef, Barnes Ashley, Song Yang, Eisenman David J, Eliyahu Efrat, Frolenkov Gregory I, Strome Scott E, Durand B\u00e9n\u00e9dicte, Zaghloul Norann A, Jones Sherri M, Reith Walter, Hertzano Ronna", "evidence": [ { "database": "UniProtKB", "id": "A0A0F7C9F3", "url": "https://www.uniprot.org/uniprotkb/A0A0F7C9F3" } ], "reference": [ { "type": "PubMed", "id": "26469318", "url": "https://glygen.org/publication/PubMed/26469318" } ] }, { "title": "A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK- and PI3K-induced malignant growth.", "journal": "Dis. Model. Mech.", "date": "2017", "authors": "Mayrhofer Marie, Gourain Victor, Reischl Markus, Affaticati Pierre, Jenett Arnim, Joly Jean-Stephane, Benelli Matteo, Demichelis Francesca, Poliani Pietro Luigi, Sieger Dirk, Mione Marina", "evidence": [ { "database": "UniProtKB", "id": "A0A0F7C9F3", "url": "https://www.uniprot.org/uniprotkb/A0A0F7C9F3" } ], "reference": [ { "type": "PubMed", "id": "27935819", "url": "https://glygen.org/publication/PubMed/27935819" } ] } ], "pathway": [ { "id": "dre:100002928", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?dre:100002928", "resource": "KEGG Pathway" }, { "id": "R-DRE-373753", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-DRE-373753", "resource": "Reactome", "description": "Nephrin family interactions" }, { "id": "R-DRE-5626467", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-DRE-5626467", "resource": "Reactome", "description": "RHO GTPases activate IQGAPs" }, { "id": "R-DRE-6798695", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-DRE-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" }, { "id": "R-DRE-8980692", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-DRE-8980692", "resource": "Reactome", "description": "RHOA GTPase cycle" }, { "id": "R-DRE-9013404", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-DRE-9013404", "resource": "Reactome", "description": "RAC2 GTPase cycle" }, { "id": "R-DRE-9013406", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-DRE-9013406", "resource": "Reactome", "description": "RHOQ GTPase cycle" }, { "id": "R-DRE-9013420", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-DRE-9013420", "resource": "Reactome", "description": "RHOU GTPase cycle" }, { "id": "R-DRE-9013424", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-DRE-9013424", "resource": "Reactome", "description": "RHOV GTPase cycle" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0F7EVQ6-1", "protein_name": "Ras GTPase-activating-like protein IQGAP3", "gene_name": "iqgap3", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MGDGVQQRSVYERLTAEEMDEQRIQNVAYQYLCRLEEAKRWMEECLKEDLPAPTELEEALRNGVYLAKLGHCFAPRVVPLKKIYDLDQQRYKVSGLQFRHTDNINHWRNAMMEVGLPTIFHPETTDVYDKKNMPRAVYCIHALSLYLFRLGLAPQIHDLRGKVKFTEEEINNMKLELDKYGIQMPAFSKIGGILANELSVDEAAVRAAVIAINEAVDRGCVQTTAQTLRNPNAMLSALQDPLMPVYQQMLQQARVQKAARARTNTSEEKDIYEEYLTQREIQDSINTVNMRAAVERVDEALDCSDAQALLCALQNSSLALRGLIRDHASWYLEQLSADREQKALDLGCVDPLEREELQEGINMANEDAKRDQTMQQAVCKINEAVRRGEARQTVRALMNPDAHLPDVYPFAAELYQRELAPLQRQCPQAELQQEELYVAVEMLSAVALVNQALEVRDFGAFSSTVISPAAGLTDIDDSLIQRYFEELCELKRSAGKSLLSWNDLQTGLNAVNTSAHEEHEQIVTIGLINQALSRSDPQKTLSALMLPSSGLEDVQPLNARRYHDLLIRARRHKAELSRDPGAELWLADIQEGVRLANQDTQKALKMCLGLAAVNQAVKECKASQTLRVLRLPEVALRSVVSECADGYQTELTALLRAKTLEGDNRSPWMMTKLADSSSYFFHLQKLEGSWERPQGFVQNSTFLTHEEIQAVCSGVTAAHSRDVQWRASEPLVLQLQARMRGFLLRLKLQERLHFLNTQLPAVITIQSHWRRFTQQREYKRRLQYLYRNWRAIVKIQATVKMWIARRRYLARLAYFRRHVGAIIRIQAFFRASRTREEYRLLVHSSTPPLSVVRKFAHLLEFGDSDIRQEGELLRLREDVVRTIRANRQLEADLDLMDLKIGLLVRNRVTLQEVVSHCKKLTKKNKEQLSDMMALDKHKGLKALSKEKREKLEAYQHLFYLLQTQPLYLAQLIFLMPQNKSTRFMETVIFTLFNYGSDCREAFLLLQLFTAALRHEITVKVDRPQEVITGSPTVIKMLVSFYRHARGQNALKDILGPAIRDVLQDRTLNIRTDPVEIYKSWVNQSESQTGQKSCLPYEVSVDQALSHSEVQHRLNVSITNLKNLTERVLNAIISNTHRLPYGLRYTAKVLRDTLQEKFPQATEDELYKIVGNLIYYRYMNPAIVAPDGFDVVEFSAGSALLPGQRRTLGSIARILQHSAALKHFQGDSAHLHALNQYITQTHSRFRKFLRAVCDVPEPEERFSIDEYSETLILNRPVIYISISELLNTHRLLLEHQDSLCSDQSDPLLQLLNDLGSVPSVQELVGEGHLNSADPNTEQTLDKMEVSLTLTSKFDVFKSSDDQPDARGILLSTKQLIIDVIRTQPGDTLHEVLQVSASRDQEVQHGWLMHQRAQRDARTPEKMKRNQSLIADGRLTLEEKKRKIQRNIRRLEAIGTLRPHDAHTHILQLIAKDIRHQRVYRQRRQAELVKLKHTLNSLNSKSCFHSEQVDYYSQYINTCLHNLTNSKVSKKKVSDNKGKKKQATLTYTAARLHEKGVLLEIEDLPVTQFKNVIFDIVPGEEDGVFLVKARFMGVDMEKFPLKYQDLLQLQYEEVAVMKMFDKAKVNVNLLIFLLNKKFFKK", "length": 1639 }, "evidence": [ { "id": "SGD:S000006163", "url": "https://alliancegenome.org/gene/SGD:S000006163#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A0A8I6AM38-1", "protein_name": "IQ motif containing GTPase activating protein 2", "gene_name": "Iqgap2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPHEELPSLQRPRYGSIVDDERLSAEEMDERRRQNIAYEYLCHLEEAKRWMEVCLVEELPPTTELEEGLRNGVYLAKLAKFFAPKVVSEKKIYDVEQSRYKKSGLHFRHTDNTVQWLRAMEAIGLPKIFYPETTDVYDRKNIPRMIYCIHALSLYLFKLGIAPQIQDLLGKVDFTEEEISNMRKELEKYGIQMPAFSKIGGILASELSVDEAALHAAVIAINEAIEKGVAKQTIITLRNPNAVLTCVDDSLSQEYQKELWEAKKKKEETAKLKNSCISEEERDAYEELLTQAEIQSNIHAVNRMAAVDHINAVLREGDPENTLLALKKPEAQLPAVYPFAAAMYQNELFNLQKQNTSNYLAHEELLIAVEMLSAVALLNQALESNDLVAVQNQLRSPTIGFNNLDEAHVDRYADALLSVKQEALSQGQDTLSWNEIQNCIDMINNQIQEENERMVVLGYINEAIDEGNPLKTLDTLLLPTANIRGVDPDCAHHYQDVLFHTKSQKLRDPKNVSKVLWLDEIQQAINEANVDKNRAKQWVTLVVGVNECLDRKQSDDILTVLKSSSSNVHNILPECANKYFDTLMKAKESKTDGEPTEGPWVKLDVQQKYNYYYNTDSKEGSWIPPESCLCKESWLTGEEIEDIVEKVTSDYIRENLWSASEDLLLRFEATNSGPILREEFEARKAFLYKQVGNVVKIQAFWKGYKQRQEYLHRQQVFARNVDSVVKIQSWFRMVTARKSYLSRLQYFEDHENEIVKIQSLLRASKARDDYKALVGSENPPLTVIRKFVYLLDQSDLDFQEELEVARLREEVVTKIRANQQLEKDLNLMDIKIGLLVKNRITLEDVISHSKKLNKKKGGEIEILTNTDNQGIKSLSKERRKTLETYQQLFYLLQTKPSYLAKLIFQMPQNKSTKFMDTVIFTLYNYASNQREEYLLLKLFKTALEEEIKSKVDQVQDIVTGNPTVIKMVVSFNRGARGQNSLRQLLAPVVKEIIEDKALIINTNPVEVYKAWVNQLETQTGEASKLPYDVTTEQALTYPEVKNKLEASIENLRKVTDKVLSSIISSLDLLPYGLRYIAKVLKNSIREKFPDATEEELLKIVGNLLYYRYMNPAIVAPDGFDIIDMTAGGQINSNQRRNLGSVAKVLQHAASNKLFEGENEHLSSMNNYLSETYQEFRKYFQEACDVHEPEEKFNMDKYTDLVTVSKPVIYISIEEIINTHLLLLEHQDAIATEESDLLNELLESLGEVPTVESFLGEGAVDPNDPNKENTLNQLSKTEISLSLTSKYDVKDGEAIDGRSLMIKTKKLIIDVVRNQPGSTLMEILETPATEQQELEHTKDMESRAVADSRALEEGKQSQAVIEDASLPLEQKKRKIQRNLRTLEQTGHVSSKNKYQDILNEIAKDIRNQRIHRKLRKAELSKLQQTLNALNKKAAFYEDQINYYDTYIKTCVDNLKRKNSRRSIKLDGKAEPKGTKRVKPVRYTAAKLHDKGVLLGIDDLQTNQFKNVMFDIIATEDMGIFDVRSKFLGVEMEKVQLNIQDLLQMQYEGVAVMKMFDKVKVNVNLLIYLLNKKFYGK", "length": 1575 }, "evidence": [ { "id": "SGD:S000006163", "url": "https://alliancegenome.org/gene/SGD:S000006163#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "D3ZCS4-1", "protein_name": "IQ motif containing GTPase activating protein 3", "gene_name": "Iqgap3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MESCTAGQARTAYDRLTAEEMDEQRRQNVAYQYLCRLEEAKRWMEVCLKEELPSPVELEESLRNGVLLAKLGHCFAPSVVPLKKIYDMEQLRYQATGLHFRHTDNINFWLSAVAHIGLPSTFLPETTDIYDKKNMPRVIYCIHALSLFLFRLGLAPQIHDLYGKVKFTAEELSNIASELAKYGLQLPAFSKIGGILANEFSADEAAVHAAILAINDAVERGVVEDTLVALQNPNALLGNLREPLAAVYQELLALAKMEKAANARNHDDGQDQDIYESCLTQAEIQGHINLANVQGALEVVDDALERQSPEALLEALRDPVLALQGVRQAFADWYLEQLTSDREQKSQELGLVRLLEKEEIQAGVAAANEKGDQEQAMLRAVWKINKAIQRGVAADTVKELMCPEAQLPQVYPFASAVYQQELALLQKQQQGELDQEELFVAVEMLSAVVLINRALEAGDACTFWDNLVNPATGLAQVEEENAQRYFDALVKVQQLRGTHRGFLSWNDLQAAVSQVNAQVQEETDQVLAISLINEALDQGCPEKTLSALLLPAAGLEDVSLPVAPRYHHLLVAAKRQKAQKTGDPGAVLWLEEIRQGVARANEDTNTAQRIALGVAAINQAIKEGKAAQTERVLRNPNVALRGIVPDCAKSYQQALEGAAAKKHRPGDTAFWVPRDMKDGTAYYFHLQTFQGTWERPPSRHLNASHLTWEEIQSVITKVTAAHDRQLLWKANVGFVIKLQARLRGFLVRQKFAESSHFLRTLLPAVIKIQAHWRGYRQRKTYQERLQYFKANLNAIITIQAWARMWAARRQYLRRLRYFQKNVDSVVKIQAFFRARKARDDYRMLVHARHPPLSVVRKFAHLLNQSQEDFSAEAELLRLQEEVVRKIRSNQQLEQDLNLMDIKIGLLVKNRITLQEVVSHCKKLTKKNKEQLSDMMILDKQKGLKSLSREKRQKLEAYQHLFYLLQTQPIYLAKLIFQMPQNKTTKFMEGVIFSLYNYASNRREAYLLLQLFRTALQEEIKSKVEQPQDVVTGNPTVVRLVVRFYRNGRGQSALQEILGKVIQDVLEDRSVSIHTDPVHIYKSWINQVEAQTGQRSHLPYDVTPEQALSHSEVQRRLDISLRNLLAMTEKFFVAISSSVDHIPYGIRYMAKVLKTTLETKFPNATERDIYKVVGNLLYYRFLNPAVVAPDAFDIVAMAAGSSLAAPQRHALGAVAQLLQHAAAGKVFSGESRHLRILNGYLEDLHHKFRKFICRACRVPEPEERFAIDEYSDMVAVAKPMVYITVGELIGTHRLLLEHQDQLAPGHQDPLHQLLEDLGEPPTITDLIGDHVATDGHEDLSRLEVSLTLTNKFEGLETDADHNSTQSLLLSTKQMLADLIQFHPGDSLEEILTSSAPREHEEAHHRLMCWRQACDTQKPEPLQRRHSLMAHSLLPLAEKQQRVLRNLRRLQGLGLVRANDCYQGLVDELAKDICNQRRHRQRRKAEMLRLRATLQGLDAKTIFYEEQGDYYNQYTQACLDHLAPNPRSSGKGKKQPSLHYTAAQLLEKGVLVEIEDLPVSHFRNVIFDITPGDEAGRFAVNAKFLGVDMEKFQLHYQDLLQLQYEGVAVMKLFNKAKVNVNLLIFLLNKKFLRK", "length": 1632 }, "evidence": [ { "id": "SGD:S000006163", "url": "https://alliancegenome.org/gene/SGD:S000006163#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "F8VQ29-1", "protein_name": "IQ motif containing GTPase activating protein 3", "gene_name": "Iqgap3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEPCAAGRARTAYERLTAEEMDEQRRQNVAYQYLCRLEEAKRWMEVCLKEELPSPVELEESLRNGVLLAKLGHCFAPSVVPLKKIYDVEQLRYQATGLHFRHTDNINFWLSAVAHIGLPSIFLPETTDIYDKKNMPRVIYCIHALSLFLFRLGLAPQIHDLYGKVKFTAEELGNIASELAKYGLQLPAFSKIGGILANEFSADEAAVHAAILAINDAVERGVVEDTLVTLQNPNALLGNLREPLAAVYQELLALAKMEKAANARNHDDGQEQDIYESCLTQAEIQGHINLANVQGALEVVDDALERQNPGALLEALHDPVLALQGVRGTFADWYLEQLTSDREQKSQELGLVRLLEKEEIQAGVAVANEKGDEEQTMLQAVWRINKAIRRGVAADTVKELMCPEAQLPRVYPFASAFYQQELALLQKQQQGELGQEELFVAVEMLSAVVLINRALEAGDVCAFWDNLVNPATGLAQVEEENAQRYFDALVKVQQFQGTHRGILSWNDLQAAVSQVNEQVQEETDQVLAISLINEALDQGCPEKTLSALLLPAAGLEDVSLHVAPRYHLLLVAAKRQKARVTGDPGAVLWLEEIRQGVARANEDTSTAQRIALGVAAINQAIKEGKAAQTERVLRNPNVALRGIVPDCAKSYQQALEGAAAKKQCPGDTAFWVQHDMKDGTAYYLHLQTFQGTWEHPSGCHLNTSHLTWEEIQSVITKVTAAHDRQLLWKANVGFVIKLQARLRGFLVRQKFAESSHVFRTLLPAVIKIQAHWRGYRQRKAYQERLQHFKANLDAIIKIQAWARMWAARRRYLRRLRYFQKNVDSVVKIQAFFRARKARDDYRMLVHARHPPLCVVRKFAHLLNQSQEDFSAESELLKLQEEVVRKIRSNQQLEQDLNLMDIKIGLLVKNRITLQEVVSHCKKLTKKNKEQLSDMMILDKQKGLKSLSREKRQKLEAYQHLFYLLQTQPIYLAKLIFQMPQNKTTKFMEGVIFSLYNYASNRREAYLLLQLFRTALQEEIKSKVEQPQDVVTGNPTVVRLVVRFYRNGRGQSALQEILGKVIQDVLEDRSVSIHTDPVHIYKSWINQEEAQTGQRSHLPYDVTPEQALSHSEVQRRLDISLRSLLTLTEKFFVAISSSVDHIPYGMRYMAKVLKTTLEKKFPNATERDIYKVVGNLLYYRFLNPAVVAPDAFDIVAMAAGSTLAAPQRHALGAVAQLLQHAAAGQIFSGESRHLRVLNDYLEDLHLKFRKFICRACRVPEPEERFAIDEYSDMVAVAKPMVYITVGELIGTHRLLLEHQDQLAPGHQDPLHQLLEDLGEPPTISDLIGDNIATDGHVDLSRLEVSLTLTNKFEGLETDADHNSNQSLLLSTKQMLADLIQFHPGESLEEILTSSAPREHEEAHRRLMCWRQACDTQKPEPLRRHHSLMAHSLLSLSEKQQRVLRNLRRLQGLGLVRASDCYQGLVDELAKDICNQRRHRQRRKAEMLRLRTTLQGLDAKTIFYEEQGDYYNQYIQACLDHLAPKPKSSGKGKKQPSLHYTAAQLLEKGVLVEIEDLPVSHFRNVIFDITPGDEAGRFFVNAKFLGVDMEKFQLHYQDLLQLQYEGVAVMKLFNKAKVNVNLLIFLLNKKFLRK", "length": 1632 }, "evidence": [ { "id": "SGD:S000006163", "url": "https://alliancegenome.org/gene/SGD:S000006163#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "G3V7Q7-1", "protein_name": "Ras GTPase-activating-like protein IQGAP1", "gene_name": "Iqgap1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSAAEEVDGLGVVRPHYGSVLDNERLTAEEMDERRRQNVAYEYLCHLEEAKRWMEACLGEDLPPTTELEEGLRNGVYLAKLGNFFSPKVVSLKKIYDREQTRYKATGLHFRHTDNVIQWLNAMDEIGLPKIFYPETTDIYDRKNMPRCIYCIHALSLYLFKLGLAPQIQDLYGKVDFTEEEINNMKIELEKYGIQMPAFSKIGGILANELSVDEAALHAAVIAINEAIDHRVAADTFTALKNPNAMLVNLEEALAPTYQDVLYQAKQDKMTNAKNRTENSDRERDVYEELLTQAEIQGNVNKVNTSSALANINLALEQGCALTLLKALQSVALGLRGLQTQNSDWYLKQLQSDLQQKRQSGQTDPLQKEEVQAGVDAANGAAQQYQRRLAAVAAINAAIQKGIAEKTVLELMNPEAQLPQVYPFAADLYQKELATLQQQSPEHSLTHPELTVAVEMLSSVALINRALESGDMNTVWKQLSSSVTGLTNIEEENCQRYLDELMKLKAQAHAENNEFVTWNDIQACVDHVNLVVHEEHERILAIGLINEALDEGDAQKTLQALQIPAAKLEGVLPEVAQHYQDTLIRAKREKAQETQDESAVLWLDEIQGGIWQSNKDTQEAQRFALGIFAINEAVESGDVGRTLSALRSPDVGLYGVIPECGETYQSDLAEAKKKRLAAGDNNSKWVKHWVKGGYHYYHNLETQAGGWAEPPDFVQNSVQLSREEIQSSISGVTAAYNREQLWLANEGLITKLQACCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAYQDRLAYLHSHKDEVVKIQSLARMHQARKRYRDRLQYFRDHINDIIKIQAFIRANKARDDYKTLINAEDPPMIVVRKFVHLLDQSDQDFQEELDLMKMREEVITLIRSNQQLENDLNLMDIKIGLLVKNKITLQDVVSHSKKLTKKNKEQLSDMMMINKQKGGLKALSKEKREKLEAYQHLFYLLQTNPTYLAKLIFQMPQNKSTKFMDSVIFTLYNYASNQREEYLLLRLFQTALQEEIKSKVDQIQEIVTGNPTVIKMVVSFNRGARGQNALRQILAPVVKEIMDDKSLNIKTDPVDIYKSWVNQMESQTGEASKLPYDVTPEQALSHEEVKTRLDNSIRNMRAVTDKFLSAIVSSVDKIPYGMRFIAKVLKDSLHEKFPDAAEDELLKIIGNLLYYRYMNPAIVAPDAFDIIDLSAGGQLTTDQRRNLGSIAKMLQHAASNKMFLGDNAHLSIINEYLSQSYQKFRRFFQAACDVPELQDKFNVDEYSDLVTLTKPVIYISIGEIINTHTLLLDHQDAIAPEHNDPIHELLDDLGEVPTIESLIGESCGNSNDPSKEALAKTEVSLTLTNKFDVPGDENAEMDARTILLNTKRLIVDVIRFQPGETLTEILETPATNEQEAEHQRAMQRRAIRDAKTPDKMKKSKPMKEDNNLSLQEKKEKIQTGLKKLTELGTVDPKNRYQELINDIAKDIRNQRRYRQRRKAELVKLQQTYSALNSKATFYGEQVDYYKSYIKTCLDNLASKGKVSKKPREMKGKKSKKISLKYTAARLHEKGVLLEIEDLQANQFKNVIFEIGPTEEVGDFEVKAKFMGVQMETFMLHYQDLLQLQYEGVAVMKLFDRAKVNVNLLIFLLNKKFYGK", "length": 1657 }, "evidence": [ { "id": "MGI:1352757", "url": "https://alliancegenome.org/gene/MGI:1352757#orthology", "database": "AGR" }, { "id": "RGD:1311884", "url": "https://alliancegenome.org/gene/RGD:1311884#orthology", "database": "AGR" }, { "id": "SGD:S000006163", "url": "https://alliancegenome.org/gene/SGD:S000006163#orthology", "database": "AGR" }, { "id": "HGNC:6110", "url": "https://alliancegenome.org/gene/HGNC:6110#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-050809-24", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-050809-24#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P46940-1", "protein_name": "Ras GTPase-activating-like protein IQGAP1", "gene_name": "IQGAP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSAADEVDGLGVARPHYGSVLDNERLTAEEMDERRRQNVAYEYLCHLEEAKRWMEACLGEDLPPTTELEEGLRNGVYLAKLGNFFSPKVVSLKKIYDREQTRYKATGLHFRHTDNVIQWLNAMDEIGLPKIFYPETTDIYDRKNMPRCIYCIHALSLYLFKLGLAPQIQDLYGKVDFTEEEINNMKTELEKYGIQMPAFSKIGGILANELSVDEAALHAAVIAINEAIDRRIPADTFAALKNPNAMLVNLEEPLASTYQDILYQAKQDKMTNAKNRTENSERERDVYEELLTQAEIQGNINKVNTFSALANIDLALEQGDALALFRALQSPALGLRGLQQQNSDWYLKQLLSDKQQKRQSGQTDPLQKEELQSGVDAANSAAQQYQRRLAAVALINAAIQKGVAEKTVLELMNPEAQLPQVYPFAADLYQKELATLQRQSPEHNLTHPELSVAVEMLSSVALINRALESGDVNTVWKQLSSSVTGLTNIEEENCQRYLDELMKLKAQAHAENNEFITWNDIQACVDHVNLVVQEEHERILAIGLINEALDEGDAQKTLQALQIPAAKLEGVLAEVAQHYQDTLIRAKREKAQEIQDESAVLWLDEIQGGIWQSNKDTQEAQKFALGIFAINEAVESGDVGKTLSALRSPDVGLYGVIPECGETYHSDLAEAKKKKLAVGDNNSKWVKHWVKGGYYYYHNLETQEGGWDEPPNFVQNSMQLSREEIQSSISGVTAAYNREQLWLANEGLITRLQARCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAYQDRLAYLRSHKDEVVKIQSLARMHQARKRYRDRLQYFRDHINDIIKIQAFIRANKARDDYKTLINAEDPPMVVVRKFVHLLDQSDQDFQEELDLMKMREEVITLIRSNQQLENDLNLMDIKIGLLVKNKITLQDVVSHSKKLTKKNKEQLSDMMMINKQKGGLKALSKEKREKLEAYQHLFYLLQTNPTYLAKLIFQMPQNKSTKFMDSVIFTLYNYASNQREEYLLLRLFKTALQEEIKSKVDQIQEIVTGNPTVIKMVVSFNRGARGQNALRQILAPVVKEIMDDKSLNIKTDPVDIYKSWVNQMESQTGEASKLPYDVTPEQALAHEEVKTRLDSSIRNMRAVTDKFLSAIVSSVDKIPYGMRFIAKVLKDSLHEKFPDAGEDELLKIIGNLLYYRYMNPAIVAPDAFDIIDLSAGGQLTTDQRRNLGSIAKMLQHAASNKMFLGDNAHLSIINEYLSQSYQKFRRFFQTACDVPELQDKFNVDEYSDLVTLTKPVIYISIGEIINTHTLLLDHQDAIAPEHNDPIHELLDDLGEVPTIESLIGESSGNLNDPNKEALAKTEVSLTLTNKFDVPGDENAEMDARTILLNTKRLIVDVIRFQPGETLTEILETPATSEQEAEHQRAMQRRAIRDAKTPDKMKKSKSVKEDSNLTLQEKKEKIQTGLKKLTELGTVDPKNKYQELINDIARDIRNQRRYRQRRKAELVKLQQTYAALNSKATFYGEQVDYYKSYIKTCLDNLASKGKVSKKPREMKGKKSKKISLKYTAARLHEKGVLLEIEDLQVNQFKNVIFEISPTEEVGDFEVKAKFMGVQMETFMLHYQDLLQLQYEGVAVMKLFDRAKVNVNLLIFLLNKKFYGK", "length": 1657 }, "evidence": [ { "id": "MGI:1352757", "url": "https://alliancegenome.org/gene/MGI:1352757#orthology", "database": "AGR" }, { "id": "RGD:1311884", "url": "https://alliancegenome.org/gene/RGD:1311884#orthology", "database": "AGR" }, { "id": "SGD:S000006163", "url": "https://alliancegenome.org/gene/SGD:S000006163#orthology", "database": "AGR" }, { "id": "HGNC:6110", "url": "https://alliancegenome.org/gene/HGNC:6110#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-050809-24", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-050809-24#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q12280-1", "protein_name": "Ras GTPase-activating-like protein IQG1", "gene_name": "IQG1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MTAYSGSPSKPGNNNSYLNRYVENLGTNVTPPLRPQSSSKINSSLNIASPSHLKTKTSASNSSATILSKKVESSVSKLKPSLPNKLVGKYTVDLSNYSKIELRYYEFLCRVSEVKIWIEAVIEEALPSEIELCVGDSLRNGVFLAKLTQRINPDLTTVIFPAGDKLQFKHTQNINAFFGLVEHVGVPDSFRFELQDLYNKKNIPQVFETLHILISMINKKWPGKTPALTNVSGQISFTKEEIAACKKAWPRIRDFKSLGTNINTAPASPEEPKEKRSGLIKDFNKFERPNIPVEEILITPRKNITDANCSDFSNTPSPYNEAPKMSNLDVVVEKRKFTPIEPSLLGPTPSLEYSPIKNKSLSYYSPTISKYLTYDTEFYTRRSRAREEDLNYYQTFKYSPSHYSPMRRERMTEEQFLEKVVQLQNICRGVNTRFNLYIQKRLLNLFEQDILRFQACLRGNKFRVLSSMYLPIRRAKIDVPHVEAIQSRIKGSRIRYKYDKLKFTLSRFSCTVELLQAYCRSKLLKTTVNTKLNDIEISHYPLTKLQSYMRASYVRKKVMSLNTKLNDERESIMKFSAIIRGNVVRCSEDAILSAVHDVHKENISKLQSLIRGIFTRSCLASIIYSLGKENCNIIQLSACIRGNAVRHKVQSLFAPENNLSETVHDLQGLVRGILVRYTLDLVDDIVEYNNLALFQAFSRGALVRESLDQKSSFYKRNVRSVIMIQSWIRKSLQRSAYLELLDCPNPSLWAVKKFVHLLNGTATIEEVQNQLESCQASLDSENMKKERLLKSIRQQLNINGVLDKFGLLKDKDHELGISDSTIPKSKYQKYEKLFYMLQVDPSYWKLLYLKEPEFVAKNVYMTFGTVNQRMNDRERSYFTRFVCEMLQNAINEAPSIESFLDNRSQFWQTILQDFLRRESPEFFSIIVPVLDYLSDPVVDFESDPYKIYQEIHGFSSPQHCSPVDDASTKNKFIDNLRCLWHAIEMVAEIYTRKVHTIPVEIRYLCTKIFCYAADKNIEEIDSLRAISSILVNVFVSEYLVNREYYGYKDSNVQKNNQKIDILMKSLATVFEIKNFDGFLDPLNQYANEIKPHIKDVLYNVLVDPEYEQEGDRLIYLDMVSPSPKLELLTEKVLEISGKFEEYLNEFPEADILHDILEKNLDNSSFPRSGRVTLELDASAYRFLVSDDKMRKIYDQVKRAFVYMMQIEDVDTNLYDLSISTILPQDEPNFANFLEQNPKIRDDPMIQKLKPLKYFTLKNVTLKKIHELESTGTFCSSDNKLQNFLNDIANTIKNPNYAIDYVTQEIYITKETLTKISEMNHSLDIELSRLKKHVDHTIKDFQKAKDFSPVHKSKFGNFKNAVKKVQGRERSELQGMKFKWNTKQLYERGVLKTIRGEKLAELTVKVFGSSGPKFPDIIFKISTSDGSRFGIQMIDKRKGPDKRYSDDVDSFSFKDLIKTQVEPKIETWKLFHSNVVVNNSQLLHLIVSFFYKRNAL", "length": 1495 }, "evidence": [ { "id": "MGI:1352757", "url": "https://alliancegenome.org/gene/MGI:1352757#orthology", "database": "AGR" }, { "id": "RGD:1311884", "url": "https://alliancegenome.org/gene/RGD:1311884#orthology", "database": "AGR" }, { "id": "SGD:S000006163", "url": "https://alliancegenome.org/gene/SGD:S000006163#orthology", "database": "AGR" }, { "id": "HGNC:6110", "url": "https://alliancegenome.org/gene/HGNC:6110#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-050809-24", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-050809-24#orthology", "database": "AGR" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q13576-1", "protein_name": "Ras GTPase-activating-like protein IQGAP2", "gene_name": "IQGAP2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPHEELPSLQRPRYGSIVDDERLSAEEMDERRRQNIAYEYLCHLEEAKRWMEVCLVEELPPTTELEEGLRNGVYLAKLAKFFAPKMVSEKKIYDVEQTRYKKSGLHFRHTDNTVQWLRAMESIGLPKIFYPETTDVYDRKNIPRMIYCIHALSLYLFKLGIAPQIQDLLGKVDFTEEEISNMRKELEKYGIQMPSFSKIGGILANELSVDEAALHAAVIAINEAVEKGIAEQTVVTLRNPNAVLTLVDDNLAPEYQKELWDAKKKKEENARLKNSCISEEERDAYEELLTQAEIQGNINKVNRQAAVDHINAVIPEGDPENTLLALKKPEAQLPAVYPFAAAMYQNELFNLQKQNTMNYLAHEELLIAVEMLSAVALLNQALESNDLVSVQNQLRSPAIGLNNLDKAYVERYANTLLSVKLEVLSQGQDNLSWNEIQNCIDMVNAQIQEENDRVVAVGYINEAIDEGNPLRTLETLLLPTANISDVDPAHAQHYQDVLYHAKSQKLGDSESVSKVLWLDEIQQAVDDANVDKDRAKQWVTLVVDVNQCLEGKKSSDILSVLKSSTSNANDIIPECADKYYDALVKAKELKSERVSSDGSWLKLNLHKKYDYYYNTDSKESSWVTPESCLYKESWLTGKEIEDIIEEVTVGYIRENIWSASEELLLRFQATSSGPILREEFEARKSFLHEQEENVVKIQAFWKGYKQRKEYMHRRQTFIDNTDSIVKIQSWFRMATARKSYLSRLQYFRDHNNEIVKIQSLLRANKARDDYKTLVGSENPPLTVIRKFVYLLDQSDLDFQEELEVARLREEVVTKIRANQQLEKDLNLMDIKIGLLVKNRITLEDVISHSKKLNKKKGGEMEILNNTDNQGIKSLSKERRKTLETYQQLFYLLQTNPLYLAKLIFQMPQNKSTKFMDTVIFTLYNYASNQREEYLLLKLFKTALEEEIKSKVDQVQDIVTGNPTVIKMVVSFNRGARGQNTLRQLLAPVVKEIIDDKSLIINTNPVEVYKAWVNQLETQTGEASKLPYDVTTEQALTYPEVKNKLEASIENLRRVTDKVLNSIISSLDLLPYGLRYIAKVLKNSIHEKFPDATEDELLKIVGNLLYYRYMNPAIVAPDGFDIIDMTAGGQINSDQRRNLGSVAKVLQHAASNKLFEGENEHLSSMNNYLSETYQEFRKYFKEACNVPEPEEKFNMDKYTDLVTVSKPVIYISIEEIISTHSLLLEHQDAIAPEKNDLLSELLGSLGEVPTVESFLGEGAVDPNDPNKANTLSQLSKTEISLVLTSKYDIEDGEAIDSRSLMIKTKKLIIDVIRNQPGNTLTEILETPATAQQEVDHATDMVSRAMIDSRTPEEMKHSQSMIEDAQLPLEQKKRKIQRNLRTLEQTGHVSSENKYQDILNEIAKDIRNQRIYRKLRKAELAKLQQTLNALNKKAAFYEEQINYYDTYIKTCLDNLKRKNTRRSIKLDGKGEPKGAKRAKPVKYTAAKLHEKGVLLDIDDLQTNQFKNVTFDIIATEDVGIFDVRSKFLGVEMEKVQLNIQDLLQMQYEGVAVMKMFDKVKVNVNLLIYLLNKKFYGK", "length": 1575 }, "evidence": [ { "id": "SGD:S000006163", "url": "https://alliancegenome.org/gene/SGD:S000006163#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q3UQ44-1", "protein_name": "Ras GTPase-activating-like protein IQGAP2", "gene_name": "Iqgap2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPHEELPSLQRPRYGSIVDDERLSAEEMDERRRQNIAYEYLCHLEEAKRWMEVCLVEELPPTTELEEGLRNGVYLAKLAKFFAPKMVSEKKIYDVEQTRYKKSGLHFRHTDNTVQWLRAMEAIGLPKIFYPETTDVYDRKNIPRMIYCIHALSLYLFKLGIAPQIQDLLGKVDFTEEEISNMRKELEKYGIQMPAFSKIGGILANELSVDEAALHAAVIAINEAIEKGVAKQTIITLRNPNAVLTCVDDSLSQEYQKELWEAKKKKEESAKLKNSCISEEERDAYEELLTQAEIQSNISTVNRMAAVDHINAVLQEGDPENTLLALKKPEAQLPAVYPFAAVMYQNELFNLQKQNTSNYLAHEELLIAVEMLSAVALLNQALESSDLVAVQNQLRSPTIGFNNLDEAHVDRYADALLSVKQEALSQGQDTLSWNEIQNCIDMINNQIQEENDRMVVLGYINEAIDAGNPLKTLDTLLLPTANIRDVDPDCAQHYQDVLFYTKSQKLGDPKNVSKVLWLDEIQQAINEANVDENRAKQWVTLVVDVNECLDRKQSDHILTALKSSPSNIHNILPECANKYYDTLVKAKESKTDNESSEGSWVTLNVQEKYNYYYNTDSKEGSWVPPELCLSKESWLTGEEIEDIVEEVTSDYIREKLWSASEDLLVRFEATTLGPALREEFEARKAFLYEQTESVVKIQAFWKGFKQRQEYLHRQQVFAGNVDSVVKIQSWFRMVTARKSYLSRLRYFEDHKNEIVKIQSLLRASKARDDYKALVGSENPPLTVIRKFVYLLDQSDLDFQEELEVARLREEVVTKIRANQQLEKDLNLMDIKIGLLVKNRITLEDVISHRKKLNKKKGGEIEILNNTDNKGIKSLSKERRKTLETYQQLFYLLQTKPSYLAKLIFQMPQNKSTKFMDTVIFTLYNYASNQREEYLLLKLFKTALEEEIKSKVDQVQDIVTGNPTVIKMVVSFNRGARGQNTLRQLLAPVVKEIIEDKALVINTNPVEVYKAWVNQLETQTGEASKLPYDVTTEQALTYPEVKNKLEASIENLRKVTDKVLGSIISSLDLLPYGLRYIAKVLKNSIREKFPDATEEELLKIVGNLLYYRYMNPAIVAPDGFDIIDMTAGGQINSNQRRNLGSVAKVLQHAASNKLFEGENEHLSSMNNYLSETYQEFRKYFQEACDVPEPEEKFNMDKYTDLVTVSKPVIYISIEEIINTHLLLLEHQDAIATEKSDLLNELLESLGEVPTVESFLGEGAVDPNDPNKENTLNQLSKTEISLSLTSKYDVKDGEAVDGRSLMIKTKKLIIDVTRNQPGSTLTEILETPATGQQELEHAKDMESRAVVDSRTPEEGKQSQAVIEDARLPLEQKKRKIQRNLRTLEQTGHVSSKNKYQDILNEIAKDIRNQRIHRKLRKAELSKLQQTLNALNKKAAFYEDQINYYDTYIKTCVDNLKRKNSRRSIKLDGKAEPKGTKRVKPVRYTAAKLHDKGVLLGIDDLQTNQFKNVMFDIIATEDMGIFDVRSKFLGVEMEKVQLNIQDLLQMQYEGVAVMKMFDKVKVNVNLLIYLLNKKFYGK", "length": 1575 }, "evidence": [ { "id": "SGD:S000006163", "url": "https://alliancegenome.org/gene/SGD:S000006163#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q86VI3-1", "protein_name": "Ras GTPase-activating-like protein IQGAP3", "gene_name": "IQGAP3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MERRAAGPGWAAYERLTAEEMDEQRRQNVAYQYLCRLEEAKRWMEACLKEELPSPVELEESLRNGVLLAKLGHCFAPSVVPLKKIYDVEQLRYQATGLHFRHTDNINFWLSAIAHIGLPSTFFPETTDIYDKKNMPRVVYCIHALSLFLFRLGLAPQIHDLYGKVKFTAEELSNMASELAKYGLQLPAFSKIGGILANELSVDEAAVHAAVLAINEAVERGVVEDTLAALQNPSALLENLREPLAAVYQEMLAQAKMEKAANARNHDDRESQDIYDHYLTQAEIQGNINHVNVHGALEVVDDALERQSPEALLKALQDPALALRGVRRDFADWYLEQLNSDREQKAQELGLVELLEKEEVQAGVAAANTKGDQEQAMLHAVQRINKAIRRRVAADTVKELMCPEAQLPPVYPVASSMYQLELAVLQQQQGELGQEELFVAVEMLSAVVLINRALEARDASGFWSSLVNPATGLAEVEGENAQRYFDALLKLRQERGMGEDFLSWNDLQATVSQVNAQTQEETDRVLAVSLINEALDKGSPEKTLSALLLPAAGLDDVSLPVAPRYHLLLVAAKRQKAQVTGDPGAVLWLEEIRQGVVRANQDTNTAQRMALGVAAINQAIKEGKAAQTERVLRNPAVALRGVVPDCANGYQRALESAMAKKQRPADTAFWVQHDMKDGTAYYFHLQTFQGIWEQPPGCPLNTSHLTREEIQSAVTKVTAAYDRQQLWKANVGFVIQLQARLRGFLVRQKFAEHSHFLRTWLPAVIKIQAHWRGYRQRKIYLEWLQYFKANLDAIIKIQAWARMWAARRQYLRRLHYFQKNVNSIVKIQAFFRARKAQDDYRILVHAPHPPLSVVRRFAHLLNQSQQDFLAEAELLKLQEEVVRKIRSNQQLEQDLNIMDIKIGLLVKNRITLQEVVSHCKKLTKRNKEQLSDMMVLDKQKGLKSLSKEKRQKLEAYQHLFYLLQTQPIYLAKLIFQMPQNKTTKFMEAVIFSLYNYASSRREAYLLLQLFKTALQEEIKSKVEQPQDVVTGNPTVVRLVVRFYRNGRGQSALQEILGKVIQDVLEDKVLSVHTDPVHLYKNWINQTEAQTGQRSHLPYDVTPEQALSHPEVQRRLDIALRNLLAMTDKFLLAITSSVDQIPYGMRYVAKVLKATLAEKFPDATDSEVYKVVGNLLYYRFLNPAVVAPDAFDIVAMAAGGALAAPQRHALGAVAQLLQHAAAGKAFSGQSQHLRVLNDYLEETHLKFRKFIHRACQVPEPEERFAVDEYSDMVAVAKPMVYITVGELVNTHRLLLEHQDCIAPDHQDPLHELLEDLGELPTIPDLIGESIAADGHTDLSKLEVSLTLTNKFEGLEADADDSNTRSLLLSTKQLLADIIQFHPGDTLKEILSLSASREQEAAHKQLMSRRQACTAQTPEPLRRHRSLTAHSLLPLAEKQRRVLRNLRRLEALGLVSARNGYQGLVDELAKDIRNQHRHRHRRKAELVKLQATLQGLSTKTTFYEEQGDYYSQYIRACLDHLAPDSKSSGKGKKQPSLHYTAAQLLEKGVLVEIEDLPASHFRNVIFDITPGDEAGKFEVNAKFLGVDMERFQLHYQDLLQLQYEGVAVMKLFNKAKVNVNLLIFLLNKKFLRK", "length": 1631 }, "evidence": [ { "id": "SGD:S000006163", "url": "https://alliancegenome.org/gene/SGD:S000006163#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q9JKF1-1", "protein_name": "Ras GTPase-activating-like protein IQGAP1", "gene_name": "Iqgap1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSAAEEVDGLGVVRPHYGSVLDNERLTAEEMDERRRQNVAYEYLCHLEEAKRWMEACLGEDLPPTTELEEGLRNGVYLAKLGNFFSPKVVSLKKIYDREQTRYKATGLHFRHTDNVIQWLNAMDEIGLPKIFYPETTDIYDRKNMPRCIYCIHALSLYLFKLGLAPQIQDLYGKVDFTEEEINNMKIELEKYGIQMPAFSKIGGILANELSVDEAALHAAVIAINEAIDRRVAADTFTALKNPNAMLVNLEEGLAPTYQDVLYQAKQDKMTNAKNRTENSDRERDVYEELLTQAEIQGNVNKVNTSSALANISLALEQGCAVTLLKALQSLALGLRGLQTQNSDWYMKQLQSDLQQKRQSGQTDPLQKEEVQAGVDAANSAAQQYQRRLAAVAAINAAIQKGIAEKTVLELMNPEAQLPQVYPFAADLYQKELATLQQQSPEHSLTHPELTVAVEMLSSVALINRALESGDMTTVWKQLSSSVTGLTNIEEENCQRYLDELMKLKAQAHAENNAFITWNDIQACVDHVNLVVHEEHERILAIGLINEALDEGDAQKTLQALQIPAAKLEGVLAEVAQHYQDTLIRAKREKAQETQDESAVLWLDEIQGGIWQSNKDTQEAQRFALGISAINEAVDSGDVGRTLSALRSPDVGLYGVIPECGETYQSDLAEAKKKRLAAGDNNSKWVKHWVKGGYHYYHNLETQAGGWAEPPDFVQNSVQLSREEIQSSISGVTAAYNREQLWLANEGLITKLQACCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAYQDRLAYLHSHKDEVVKIQSLARMHQARKRYRDRLQYFRDHINDIIKIQAFIRANKARDDYKTLINAEDPPMIVVRKFVHLLDQSDQDFQEELDLMKMREEVITLIRSNQQLENDLNLMDIKIGLLVKNKITLQDVVSHSKKLTKKNKEQLSDMMMINKQKGGLKALSKEKREKLEAYQHLFYLLQTNPTYLAKLIFQMPQNKSTKFMDSVIFTLYNYASNQREEYLLLRLFQTALQEEIKSKVDQIQEIVTGNPTVIKMVVSFNRGARGQNALRQILAPVVKEIMDDKSLNIKTDPVDIYKSWVNQMESQTGEASKLPYDVTPEQALSHEEVKTRLDNSIRNMRAVTDKFLSAIVSSVDKIPYGMRFIAKVLKDSLHEKFPDAGEDELLKIIGNLLYYRYMNPAIVAPDAFDIIDLSAGGQLTTDQRRNLGSIAKMLQHAASNKMFLGDNAHLSIINEYLSQSYQKFRRFFQVACDVPELQDKFNVDEYSDLVTLTKPVIYISIGEIINTHTLLLDHQDAIAPEHNDPIHELLDDLGEVPTIESLIGESCGNSNDPNKEALAKTEVSLTLTNKFDVPGDENAEMDARTILLNTKRLIVDVIRFQPGETLTEILETPATNEQEAEHQRAMQRRAIRDAKTPDKMKKSKPMKEDNNLSLQEKKEKIQTGLKKLTELGTVDPKNRYQELINDIAKDIRNQRRYRQRRKAELVKLQQTYSALNSKATFYGEQVDYYKSYIKTCLDNLASKGKVSKKPREMKGKKSKKISLKYTAARLHEKGVLLEIEDLQANQFKNVIFEIGPTEEVGDFEVKAKFMGVQMETFMLHYQDLLQLQYEGVAVMKLFDRAKVNVNLLIFLLNKKFYGK", "length": 1657 }, "evidence": [ { "id": "MGI:1352757", "url": "https://alliancegenome.org/gene/MGI:1352757#orthology", "database": "AGR" }, { "id": "RGD:1311884", "url": "https://alliancegenome.org/gene/RGD:1311884#orthology", "database": "AGR" }, { "id": "SGD:S000006163", "url": "https://alliancegenome.org/gene/SGD:S000006163#orthology", "database": "AGR" }, { "id": "HGNC:6110", "url": "https://alliancegenome.org/gene/HGNC:6110#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-050809-24", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-050809-24#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "A0A0F7C9F3", "url": "https://www.uniprot.org/uniprotkb/A0A0F7C9F3" } ], "pmid": "" }, { "name": "calmodulin binding", "id": "GO:0005516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005516", "evidence": [ { "database": "UniProtKB", "id": "A0A0F7C9F3", "url": "https://www.uniprot.org/uniprotkb/A0A0F7C9F3" } ], "pmid": "" }, { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "A0A0F7C9F3", "url": "https://www.uniprot.org/uniprotkb/A0A0F7C9F3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A0F7C9F3", "url": "https://www.uniprot.org/uniprotkb/A0A0F7C9F3" } ], "pmid": "" }, { "name": "cell cortex", "id": "GO:0005938", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005938", "evidence": [ { "database": "UniProtKB", "id": "A0A0F7C9F3", "url": "https://www.uniprot.org/uniprotkb/A0A0F7C9F3" } ], "pmid": "" }, { "name": "plasma membrane bounded cell projection", "id": "GO:0120025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120025", "evidence": [ { "database": "UniProtKB", "id": "A0A0F7C9F3", "url": "https://www.uniprot.org/uniprotkb/A0A0F7C9F3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "epidermal growth factor receptor signaling pathway", "id": "GO:0007173", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007173", "evidence": [ { "database": "UniProtKB", "id": "A0A0F7C9F3", "url": "https://www.uniprot.org/uniprotkb/A0A0F7C9F3" } ], "pmid": "" }, { "name": "fibroblast migration", "id": "GO:0010761", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010761", "evidence": [ { "database": "UniProtKB", "id": "A0A0F7C9F3", "url": "https://www.uniprot.org/uniprotkb/A0A0F7C9F3" } ], "pmid": "" }, { "name": "mitotic actomyosin contractile ring assembly actin filament organization", "id": "GO:1903479", "url": 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