{ "uniprot_canonical_ac": "A0A0A0MPL5-1", "uniprot_ac": "A0A0A0MPL5", "uniprot_id": "A0A0A0MPL5_DANRE", "mass": { "chemical_mass": 54598.0, "monoisotopic_mass": 54598.0 }, "refseq": {}, "gene_names": [ { "name": "fscn1b", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0A0MPL5", "id": "A0A0A0MPL5" } ], "protein_names": [ { "name": "Fascin", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A0A0MPL5/entry#names_and_taxonomy", "id": "A0A0A0MPL5" } ], "function": [], "disease": [ { "disease_id": "DOID:1793", "recommended_name": { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic cancer", "description": "An endocrine gland cancer located_in the pancreas." }, "synonyms": [ { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreas neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic tumor", "description": "" } ], "unlinked_id_list": [ "DOID:1795" ], "evidence": [ { "id": "1793", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1793" } ] }, { "disease_id": "DOID:3587", "recommended_name": { "id": "DOID:3587", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3587", "name": "pancreatic ductal carcinoma", "description": "A pancreatic carcinoma located_in the pancreatic duct." }, "synonyms": [ { "id": "DOID:3587", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3587", "name": "malignant neoplasm of duct of Wirsung", "description": "" }, { "id": "DOID:3587", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3587", "name": "pancreatic duct cancer", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "3587", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3587" } ] }, { "disease_id": "DOID:4608", "recommended_name": { "id": "DOID:4608", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4608", "name": "common bile duct neoplasm", "description": "" }, "synonyms": [ { "id": "DOID:4608", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4608", "name": "neoplasm of common bile duct", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "4608", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4608" } ] }, { "disease_id": "DOID:4947", "recommended_name": { "id": "DOID:4947", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4947", "name": "cholangiocarcinoma", "description": "A bile duct adenocarcinoma that has_material_basis_in bile duct epithelial cells." }, "synonyms": [ { "id": "DOID:4947", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4947", "name": "adult primary Cholangiocarcinoma", "description": "" }, { "id": "DOID:4947", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4947", "name": "adult primary cholangiocellular carcinoma", "description": "" }, { "id": "DOID:4947", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4947", "name": "cholangiosarcoma", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "4947", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:4947" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Danio rerio", "taxid": 7955, "evidence": [ { "database": "UniProtKB", "id": "A0A0A0MPL5", "url": "https://www.uniprot.org/uniprotkb/A0A0A0MPL5" } ], "common_name": "Zebrafish", "glygen_name": "Zebrafish", "reference_species": "Danio rerio [7955]" } ], "gene": [ { "name": "fscn1b", "url": "https://www.uniprot.org/uniprotkb/A0A0A0MPL5", "locus": {} } ], "crossref": [ { "id": "ZFIN:ZDB-GENE-120507-1", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-120507-1", "database": "AGR", "categories": [ "Protein Classification" ] }, { "id": "ENSDARG00000037747", "url": "https://bgee.org/?page=gene&gene_id=ENSDARG00000037747", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd23344", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23344", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd23348", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd23348", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "570314", "url": "https://www.ncbi.nlm.nih.gov/gene/570314", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR008999", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008999", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010431", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010431", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022768", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022768", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024703", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024703", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dre:570314", "url": "https://www.genome.jp/dbget-bin/www_bget?dre:570314", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ECNKAIY", "url": "https://omabrowser.org/oma/group/ECNKAIY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A0A0MPL5", "url": "https://www.orthodb.org/?gene=A0A0A0MPL5", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10551", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10551", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10551:SF39", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10551:SF39", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF06268", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF06268", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "XP_005170934", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005170934", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A0A0MPL5", "url": "https://www.uniprot.org/uniprotkb/A0A0A0MPL5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0A0MPL5-1", "url": "https://www.uniprot.org/uniprotkb/A0A0A0MPL5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "ZDB-GENE-120507-1", "url": "https://zfin.org/ZDB-GENE-120507-1", "database": "ZFIN", "categories": [ "Protein", "Organism-specific" ] } ], "sequence": { "sequence": "MSSEGIGETLVIRFGLINADNKYLTAEMFGFKINASASSMKKKQVWTLEQSGDHGDSNAVFIKSHLGRYLASDKDGKVTADSEQPGPDCRFLVIAHDDGRWSLQSEPHARYLGGTEDRIACFAQSISPAEKWNVHLAVHPQVNVYSIARKRYAHLCADRNELAVDRDVPWGVDSLLTLVYLDHRYHLQTADNRFLSCGGTLTAKPDRDTGFTLEFRAGKVAFRDATGKYIAPTGPTGTMKSGRSARVGKDELFVLEQSHGQVVLTASNDRNISMRQGVDLSANQDEESDQEVFQMEMDRESKRCAFRSFNGRYWSLTSSGAIQCSALTKSPSCFFDLEWKGSKVALKASNGKYLAAKKNGQLAAAVDSAGEQEEFVLKLINRPLIVLRGEHGFIGCRKQGTGTLDSNRSSYDVFQLEYNNNAYSLRDSVGKYWTVESDGSVISSGAAPVYFHFEFCDFNKVAIKTKEGKYLKGDHAGVLKASAQGIADATLWEY", "length": 494, "header": "tr|A0A0A0MPL5-1|A0A0A0MPL5_DANRE Isoform 1 of Fascin OS=Danio rerio OX=7955 GN=fscn1b PE=1 SV=1 CANONICAL=A0A0A0MPL5-1" }, "isoforms": [ { "isoform_ac": "A0A0A0MPL5-1", "url": "https://www.uniprot.org/uniprotkb/A0A0A0MPL5/entry#A0A0A0MPL5-1", "sequence": { "sequence": "MSSEGIGETLVIRFGLINADNKYLTAEMFGFKINASASSMKKKQVWTLEQSGDHGDSNAVFIKSHLGRYLASDKDGKVTADSEQPGPDCRFLVIAHDDGRWSLQSEPHARYLGGTEDRIACFAQSISPAEKWNVHLAVHPQVNVYSIARKRYAHLCADRNELAVDRDVPWGVDSLLTLVYLDHRYHLQTADNRFLSCGGTLTAKPDRDTGFTLEFRAGKVAFRDATGKYIAPTGPTGTMKSGRSARVGKDELFVLEQSHGQVVLTASNDRNISMRQGVDLSANQDEESDQEVFQMEMDRESKRCAFRSFNGRYWSLTSSGAIQCSALTKSPSCFFDLEWKGSKVALKASNGKYLAAKKNGQLAAAVDSAGEQEEFVLKLINRPLIVLRGEHGFIGCRKQGTGTLDSNRSSYDVFQLEYNNNAYSLRDSVGKYWTVESDGSVISSGAAPVYFHFEFCDFNKVAIKTKEGKYLKGDHAGVLKASAQGIADATLWEY", "length": 494, "header": "tr|A0A0A0MPL5-1|A0A0A0MPL5_DANRE Isoform 1 of Fascin OS=Danio rerio OX=7955 GN=fscn1b PE=1 SV=1 CANONICAL=A0A0A0MPL5-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "start_pos": 233, "start_aa": "Thr", "end_pos": 233, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr233", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "00000000000000001000.00000000001000.0.xxxxx" }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "other", "prediction_tool_list": [ { "label": "isoglyp", "url": "https://github.com/jonmohl/ISOGlyP" } ], "site_category": "predicted", "site_category_dict": { "predicted": true }, "site_seq": "", "relation": "attached", "comment": "", "start_pos": 236, "start_aa": "Thr", "end_pos": 236, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr236", "evidence": [ { "id": "", "database": "GlyGen", "url": "https://data.glygen.org/" } ], "filter_code": "00000000000000001000.00000000001000.0.xxxxx" } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "The zebrafish reference genome sequence and its relationship to the human genome.", "journal": "Nature", "date": "2013", "authors": "Howe Kerstin, Clark Matthew D, Torroja Carlos F, Torrance James, Berthelot Camille, Muffato Matthieu, Collins John E, Humphray Sean, McLaren Karen, Matthews Lucy, McLaren Stuart, Sealy Ian, Caccamo Mario, Churcher Carol, Scott Carol, Barrett Jeffrey C, Koch Romke, Rauch Gerd-J\u00f6rg, White Simon, Chow William, Kilian Britt, Quintais Leonor T, Guerra-Assun\u00e7\u00e3o Jos\u00e9 A, Zhou Yi, Gu Yong, Yen Jennifer, Vogel Jan-Hinnerk, Eyre Tina, Redmond Seth, Banerjee Ruby, Chi Jianxiang, Fu Beiyuan, Langley Elizabeth, Maguire Sean F, Laird Gavin K, Lloyd David, Kenyon Emma, Donaldson Sarah, Sehra Harminder, Almeida-King Jeff, Loveland Jane, Trevanion Stephen, Jones Matt, Quail Mike, Willey Dave, Hunt Adrienne, Burton John, Sims Sarah, McLay Kirsten, Plumb Bob, Davis Joy, Clee Chris, Oliver Karen, Clark Richard, Riddle Clare, Elliot David, Eliott David, Threadgold Glen, Harden Glenn, Ware Darren, Begum Sharmin, Mortimore Beverley, Mortimer Beverly, Kerry Giselle, Heath Paul, Phillimore Benjamin, Tracey Alan, Corby Nicole, Dunn Matthew, Johnson Christopher, Wood Jonathan, Clark Susan, Pelan Sarah, Griffiths Guy, Smith Michelle, Glithero Rebecca, Howden Philip, Barker Nicholas, Lloyd Christine, Stevens Christopher, Harley Joanna, Holt Karen, Panagiotidis Georgios, Lovell Jamieson, Beasley Helen, Henderson Carl, Gordon Daria, Auger Katherine, Wright Deborah, Collins Joanna, Raisen Claire, Dyer Lauren, Leung Kenric, Robertson Lauren, Ambridge Kirsty, Leongamornlert Daniel, McGuire Sarah, Gilderthorp Ruth, Griffiths Coline, Manthravadi Deepa, Nichol Sarah, Barker Gary, Whitehead Siobhan, Kay Michael, Brown Jacqueline, Murnane Clare, Gray Emma, Humphries Matthew, Sycamore Neil, Barker Darren, Saunders David, Wallis Justene, Babbage Anne, Hammond Sian, Mashreghi-Mohammadi Maryam, Barr Lucy, Martin Sancha, Wray Paul, Ellington Andrew, Matthews Nicholas, Ellwood Matthew, Woodmansey Rebecca, Clark Graham, Cooper James D, Cooper James, Tromans Anthony, Grafham Darren, Skuce Carl, Pandian Richard, Andrews Robert, Harrison Elliot, Kimberley Andrew, Garnett Jane, Fosker Nigel, Hall Rebekah, Garner Patrick, Kelly Daniel, Bird Christine, Palmer Sophie, Gehring Ines, Berger Andrea, Dooley Christopher M, Ersan-\u00dcr\u00fcn Z\u00fcbeyde, Eser Cigdem, Geiger Horst, Geisler Maria, Karotki Lena, Kirn Anette, Konantz Judith, Konantz Martina, Oberl\u00e4nder Martina, Rudolph-Geiger Silke, Teucke Mathias, Lanz Christa, Raddatz G\u00fcnter, Osoegawa Kazutoyo, Zhu Baoli, Rapp Amanda, Widaa Sara, Langford Cordelia, Yang Fengtang, Schuster Stephan C, Carter Nigel P, Harrow Jennifer, Ning Zemin, Herrero Javier, Searle Steve M J, Enright Anton, Geisler Robert, Plasterk Ronald H A, Lee Charles, Westerfield Monte, de Jong Pieter J, Zon Leonard I, Postlethwait John H, N\u00fcsslein-Volhard Christiane, Hubbard Tim J P, Roest Crollius Hugues, Rogers Jane, Stemple Derek L", "evidence": [ { "database": "UniProtKB", "id": "A0A0A0MPL5", "url": "https://www.uniprot.org/uniprotkb/A0A0A0MPL5" } ], "reference": [ { "type": "PubMed", "id": "23594743", "url": "https://glygen.org/publication/PubMed/23594743" } ] } ], "pathway": [ { "id": "dre:570314", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?dre:570314", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "B2LT49-1", "protein_name": "Fascin", "gene_name": "fscn2a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MSTNGISAALKLQFGLINHENRYLTAEAFGFKINASGNSMKKKQIWTLEQDPDSQVVFLRSHLGRYLSSDKDGKVRCEEEVPNTDCRFLIVMQSDGRWALQSEPYLRYFGGSEEYLSCFAQTIGESELWALHLALHPQANLLSVARKRYAHLSTQEDEISMDSNIPWGVDSLITLVYLEGKYSLKTCDNRFLKNDGKLVMEHGPNTSFTLELKSGKLAFKDCEGKYLSPNGPTGTLKSGRCTRPGKDELFDLEESHPQVVFQAANKRYVSIRVCISANQDDETDMETFQMEIDKETKKCMFRTNGGNYWTLVTHGGILSSATEIEENTMFDIEWLGRRIALKASNGKYVCTKKNGQLAAVSDSLGEDEQFVLKLINRPILVLRGENGFVCHHKNSNTLHGSRSFYDIFTLLFSDGGYQIKSGNQKFWYVSSSGLVCTDGDKPEDFFFEFVEYGRVGIKAQNGKYLRGDQGGTLMGDGLSVNASSLWEH", "length": 488 }, "evidence": [ { "id": "FB:FBgn0003447", "url": "https://alliancegenome.org/gene/FB:FBgn0003447#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "B2LT50-1", "protein_name": "Fascin", "gene_name": "fscn2b", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MPSNGTKALKLQFGLINHENRYLTAEAFGFKVNASAPSLKKKQIWTLEQDDQDGQVVYLRSHLGRYLASDKDGKVSCEAETKENDCRFLIVAQSDGRWALQSETYLRFFGGSEDYLSCFAQTIGEAELWAMHLALHPQANLLSVARKRYAHLASPEGEIAVDCNIPWGVDALLTLVYMDGKYCLKTSDSRFLSNDGKLSSENGRGTGYTLELKSGKLAFKDCEGKYLTPMGPTGTLRSGRCSKPGKDELFDLEESHPQVVFQAANNRFVSIRQGVSVSANQDDETDMETFQMEIDKDTRKCKFRTNEGNYWTLVAHGGIQSTATEAGANTMFDIVWLGRRVALRASNGKYVCTKKNGQLSAVSDSVGEDEQLILKLINRPILILRGENGYVCHHKNSNTLDASRSVYDIFTLQFSDGAYHIKGAGGKFWYVSSSGXVCSDGDTPEDFSFEFLEHGRIAIRGKNGKYLRGDQGGNLKGDGETADSSSLWEY", "length": 490 }, "evidence": [ { "id": "FB:FBgn0003447", "url": "https://alliancegenome.org/gene/FB:FBgn0003447#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "D3ZX02-1", "protein_name": "Fascin", "gene_name": "Fscn2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPTNGLHQVLKIQFGLVNDADRYLTAESFGFKVNASAASLKRKQIWVLEPDPGQGTAVLFRSSHLGRYLSAEEDGRVACEMDHPGRDCRFLVLPQPDGRWVLQSEPHGRFFGGVEDRLSCFATAISPAELWTVHLAIHPQAHLLSVSRRRYVHLCLQEDEMAADGDMPWGVDALLTLIFQSRRYCLKSYDSRYLRSDGRLVWEPEAHACYTLEFKAGKLAFKDCDGRYLAPVGPAGTLKAGRNTRPGKDELFDLEQSHPQVVLVAANHRYVSVRQGINVSANQDEELDHETFLMQIDQETKKCTFYSSTGGYWTLVTHGGIQATATQVSANTMFEIEWHGRRVALKASNGRYVCMKKNGQLAAISDFVGEDELFILKLINRPILVLRGLDGFVCHRRGSNQLDTNRSTYDVFHLSFRDGAYQIRGRGGGFWYTGSHGSVCSDGDLAEDFLFEFRERGRLAIRALSGKYLRGGASGLLRADADLPTGEALWEY", "length": 492 }, "evidence": [ { "id": "FB:FBgn0003447", "url": "https://alliancegenome.org/gene/FB:FBgn0003447#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "O14926-1", "protein_name": "Fascin-2", "gene_name": "FSCN2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MPTNGLHQVLKIQFGLVNDTDRYLTAESFGFKVNASAPSLKRKQTWVLEPDPGQGTAVLLRSSHLGRYLSAEEDGRVACEAEQPGRDCRFLVLPQPDGRWVLRSEPHGRFFGGTEDQLSCFATAVSPAELWTVHLAIHPQAHLLSVSRRRYVHLCPREDEMAADGDKPWGVDALLTLIFRSRRYCLKSCDSRYLRSDGRLVWEPEPRACYTLEFKAGKLAFKDCDGHYLAPVGPAGTLKAGRNTRPGKDELFDLEESHPQVVLVAANHRYVSVRQGVNVSANQDDELDHETFLMQIDQETKKCTFYSSTGGYWTLVTHGGIHATATQVSANTMFEMEWRGRRVALKASNGRYVCMKKNGQLAAISDFVGKDEEFTLKLINRPILVLRGLDGFVCHHRGSNQLDTNRSVYDVFHLSFSDGAYRIRGRDGGFWYTGSHGSVCSDGERAEDFVFEFRERGRLAIRARSGKYLRGGASGLLRADADAPAGTALWEY", "length": 492 }, "evidence": [ { "id": "FB:FBgn0003447", "url": "https://alliancegenome.org/gene/FB:FBgn0003447#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "P85845-1", "protein_name": "Fascin", "gene_name": "Fscn1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTANGTAEAVQIQFGLISCGNKYLTAEAFGFKVNASASSLKKKQIWTLEQPPDEAGSAAVCLRSHLGPYLAADKDGNVTCEREVPDGDCRFLVVAHDDGRWSLQSEAHRRYFGGTEDRLSCFAQSVSPAEKWSVHIAMHPQVNIYSVTRKRYAHLSARPADEIAVDRDVPWGVDSLITLAFQDQRYSVQTSDHRFLRHDGRLVARPEPATGFTLEFRSGKVAFRDCEGRYLAPSGPSGTLKAGKATKVGKDELFALEQSCAQVVLQAANERNVSTRQGMDLSANQDEETDQETFQLEIDRDTRKCAFRTHTGKYWTLTATGGVQSTASTKNASCYFDIEWCERRITLRASNGKFVTAKKNGQLAATVETAGDSELFLMKLINRPIIVFRGEHGFIGCRKVTGTLDANRSSYDVFQLEFNDGAYNIKDSTGKYWTVGSDSSVTSSSDTPVDFFLEFCDYNKVALKVGGRYLKGDHAGVLKACAETIDPATLWEY", "length": 493 }, "evidence": [ { "id": "HGNC:11148", "url": "https://alliancegenome.org/gene/HGNC:11148#orthology", "database": "AGR" }, { "id": "FB:FBgn0003447", "url": "https://alliancegenome.org/gene/FB:FBgn0003447#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-120507-1", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-120507-1#orthology", "database": "AGR" }, { "id": "RGD:1583309", "url": "https://alliancegenome.org/gene/RGD:1583309#orthology", "database": "AGR" }, { "id": "MGI:1352745", "url": "https://alliancegenome.org/gene/MGI:1352745#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q08C47-1", "protein_name": "Fascin", "gene_name": "fscn1a", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MTANGTSDMLKIQFGLINCGNKYLTAETFGFKINASATSMKKKQIWTLEQDGDDSNMFFLKSHLGRYIAADKDGNVTGDSETPGEDCRFIITAHDDGRWSLQSEPHKRYLGGTEDRITCFAQTISIAEKWSVHIAMHPQVNIFSVTRKRYAHLSSEQNEIAIDRDVPWGVDSLITLVFQDQRYHLQTSDNRFLKNDGSLSQTADKTTGYTLEFRSGKVAFRDCTGKYLAPSGPSGTMKSGKSMKVGKDELFVLEQSLPQVVLTAGNDRNVSTRQGMDLSANQDEEGDQETFQMEISKDTKKCAFRTCTGKYWTLTANGGLQCTASTKSANCYFDIEWRGKKITLRATNGKYVAAKKNGQLAATIDSAGETEEFLMKLINRPLIVLRGEHGFIGCRRVTGTLDSNRSSYDVFGLDFNDGAYSLRDCTGKYWMVGSESNVLSSSDTPVDFFLEFCNYNKVAIKTTEGKYLKGDHAGVLKANADDLDSSTMWEY", "length": 491 }, "evidence": [ { "id": "HGNC:11148", "url": "https://alliancegenome.org/gene/HGNC:11148#orthology", "database": "AGR" }, { "id": "FB:FBgn0003447", "url": "https://alliancegenome.org/gene/FB:FBgn0003447#orthology", "database": "AGR" }, { "id": "RGD:1583309", "url": "https://alliancegenome.org/gene/RGD:1583309#orthology", "database": "AGR" }, { "id": "MGI:1352745", "url": "https://alliancegenome.org/gene/MGI:1352745#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q16658-1", "protein_name": "Fascin", "gene_name": "FSCN1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTANGTAEAVQIQFGLINCGNKYLTAEAFGFKVNASASSLKKKQIWTLEQPPDEAGSAAVCLRSHLGRYLAADKDGNVTCEREVPGPDCRFLIVAHDDGRWSLQSEAHRRYFGGTEDRLSCFAQTVSPAEKWSVHIAMHPQVNIYSVTRKRYAHLSARPADEIAVDRDVPWGVDSLITLAFQDQRYSVQTADHRFLRHDGRLVARPEPATGYTLEFRSGKVAFRDCEGRYLAPSGPSGTLKAGKATKVGKDELFALEQSCAQVVLQAANERNVSTRQGMDLSANQDEETDQETFQLEIDRDTKKCAFRTHTGKYWTLTATGGVQSTASSKNASCYFDIEWRDRRITLRASNGKFVTSKKNGQLAASVETAGDSELFLMKLINRPIIVFRGEHGFIGCRKVTGTLDANRSSYDVFQLEFNDGAYNIKDSTGKYWTVGSDSAVTSSGDTPVDFFFEFCDYNKVAIKVGGRYLKGDHAGVLKASAETVDPASLWEY", "length": 493 }, "evidence": [ { "id": "HGNC:11148", "url": "https://alliancegenome.org/gene/HGNC:11148#orthology", "database": "AGR" }, { "id": "FB:FBgn0003447", "url": "https://alliancegenome.org/gene/FB:FBgn0003447#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-120507-1", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-120507-1#orthology", "database": "AGR" }, { "id": "RGD:1583309", "url": "https://alliancegenome.org/gene/RGD:1583309#orthology", "database": "AGR" }, { "id": "MGI:1352745", "url": "https://alliancegenome.org/gene/MGI:1352745#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q24524-1", "protein_name": "Protein singed", "gene_name": "sn", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MNGQGCELGHSNGDIISQNQQKGWWTIGLINGQHKYMTAETFGFKLNANGASLKKKQLWTLEPSNTGESIIYLRSHLNKYLSVDQFGNVLCESDERDAGSRFQISISEDGSGRWALKNESRGYFLGGTPDKLVCTAKTPGASEFWTVHLAARPQVNLRSIGRKRFAHLSESQDEIHVDANIPWGEDTLFTLEFRAEEGGRYALHTCNNKYLNANGKLQVVCNEDCLFSAEYHGGHLALRDRQGQYLSPIGSKAVLKSRSSSVTRDELFSLEDSLPQASFIAGLNLRYVSVKQGVDVTANQDEVGENETFQLEYDWSAHRWALRTTQDRYWCLSAGGGIQATGNRRCADALFELIWHGDGSLSFRANNGKFLATKRSGHLFATSESIEEIAKFYFYLINRPILVLKCEQGFVGYRTPGNLKLECNKATYETILVERAQKGLVHLKAHSGKYWRIEGESISVDADAPSDGFFLELREPTRICIRSQQGKYLGATKNGAFKLLDDGTDSATQWEF", "length": 512 }, "evidence": [ { "id": "HGNC:11148", "url": "https://alliancegenome.org/gene/HGNC:11148#orthology", "database": "AGR" }, { "id": "FB:FBgn0003447", "url": "https://alliancegenome.org/gene/FB:FBgn0003447#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-120507-1", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-120507-1#orthology", "database": "AGR" }, { "id": "RGD:1583309", "url": "https://alliancegenome.org/gene/RGD:1583309#orthology", "database": "AGR" }, { "id": "MGI:1352745", "url": "https://alliancegenome.org/gene/MGI:1352745#orthology", "database": "AGR" }, { "id": "A0A0A0MPL5", "url": "https://omabrowser.org/oma/group/A0A0A0MPL5/", "database": "OMA" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q32M02-1", "protein_name": "Fascin-2", "gene_name": "Fscn2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPTNGLHQVLKIQFGLVNDADRYLTAESFGFKVNASAASLKRKQIWVLEPDPGQGTAVLFRSSHLGRYLSAEEDGRVACEMDQPGRDCRFLVLPQPDGRWVLQSEPHGRFFGGIEDRLSCFATAISPAELWTVHLAIHPQAHLLSVSRRRYVHLCLQEDEMAADGDMPWGVDALVTLIFQSRRYCLKSYDSRYLRSDGRLVWEPEAHACYTLEFKAGKLAFKDCDGRYLAPVGPAGTLKAGRNTRPSKDELFDLEQSHPQVVLVAANRRYISVRQGINVSANQDEELGHETFLMQIDQETKKCTFYSSTGGYWTLVTHGGIQATATQVSANTMFEIEWHGRRVALKASNGRFVCMKKNGQLAAISDFVGEDELFTLKLINRPLLVLRGLDGFVCHRRGSNQLDTNRSTYDVFHLSFRDGAYQIRGRGGGFWYTGSHGSVCSDGDLAEDFLFEFRERGRLAIRALSGKYLRGGASGLLRADADLPVGEALWEY", "length": 492 }, "evidence": [ { "id": "FB:FBgn0003447", "url": "https://alliancegenome.org/gene/FB:FBgn0003447#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q61553-1", "protein_name": "Fascin", "gene_name": "Fscn1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTANGTAEAVQIQFGLISCGNKYLTAEAFGFKVNASASSLKKKQIWTLEQPPDEAGSAAVCLRSHLGRYLAADKDGNVTCEREVPDGDCRFLVVAHDDGRWSLQSEAHRRYFGGTEDRLSCFAQSVSPAEKWSVHIAMHPQVNIYSVTRKRYAHLSARPADEIAVDRDVPWGVDSLITLAFQDQRYSVQTSDHRFLRHDGRLVARPEPATGFTLEFRSGKVAFRDCEGRYLAPSGPSGTLKAGKATKVGKDELFALEQSCAQVVLQAANERNVSTRQGMDLSANQDEETDQETFQLEIDRDTRKCAFRTHTGKYWTLTATGGVQSTASTKNASCYFDIEWCDRRITLRASNGKFVTAKKNGQLAASVETAGDSELFLMKLINRPIIVFRGEHGFIGCRKVTGTLDANRSSYDVFQLEFNDGAYNIKDSTGKYWTVGSDSSVTSSSDTPVDFFLEFCDYNKVALKVGGRYLKGDHAGVLKACAETIDPASLWEY", "length": 493 }, "evidence": [ { "id": "HGNC:11148", "url": "https://alliancegenome.org/gene/HGNC:11148#orthology", "database": "AGR" }, { "id": "FB:FBgn0003447", "url": "https://alliancegenome.org/gene/FB:FBgn0003447#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-120507-1", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-120507-1#orthology", "database": "AGR" }, { "id": "RGD:1583309", "url": "https://alliancegenome.org/gene/RGD:1583309#orthology", "database": "AGR" }, { "id": "MGI:1352745", "url": "https://alliancegenome.org/gene/MGI:1352745#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A0A0MPL5", "url": "https://www.uniprot.org/uniprotkb/A0A0A0MPL5" } ], "pmid": "" }, { "name": "actin cytoskeleton", "id": "GO:0015629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015629", "evidence": [ { "database": "UniProtKB", "id": "A0A0A0MPL5", "url": "https://www.uniprot.org/uniprotkb/A0A0A0MPL5" } ], "pmid": "" }, { "name": "lamellipodium", "id": "GO:0030027", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030027", "evidence": [ { "database": "UniProtKB", "id": "A0A0A0MPL5", "url": "https://www.uniprot.org/uniprotkb/A0A0A0MPL5" } ], "pmid": "" }, { "name": "growth cone", "id": "GO:0030426", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030426", "evidence": [ { "database": "UniProtKB", "id": "A0A0A0MPL5", "url": "https://www.uniprot.org/uniprotkb/A0A0A0MPL5" } ], "pmid": "" }, { "name": "filopodium", "id": "GO:0030175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030175", "evidence": [ { "database": "UniProtKB", "id": "A0A0A0MPL5", "url": "https://www.uniprot.org/uniprotkb/A0A0A0MPL5" } ], "pmid": "" }, { "name": "ruffle", "id": "GO:0001726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001726", "evidence": [ { "database": "UniProtKB", "id": "A0A0A0MPL5", "url": "https://www.uniprot.org/uniprotkb/A0A0A0MPL5" } ], "pmid": "" }, { "name": "microvillus", "id": "GO:0005902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005902", "evidence": [ { "database": "UniProtKB", "id": "A0A0A0MPL5", "url": "https://www.uniprot.org/uniprotkb/A0A0A0MPL5" } ], "pmid": "" }, { "name": "cell projection membrane", "id": "GO:0031253", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031253", "evidence": [ { "database": "UniProtKB", "id": "A0A0A0MPL5", "url": "https://www.uniprot.org/uniprotkb/A0A0A0MPL5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "cell migration", "id": "GO:0016477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016477", "evidence": [ { "database": "UniProtKB", "id": "A0A0A0MPL5", "url": "https://www.uniprot.org/uniprotkb/A0A0A0MPL5" } ], "pmid": "" }, { "name": "actin filament bundle assembly", "id": "GO:0051017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051017", "evidence": [ { "database": "UniProtKB", "id": "A0A0A0MPL5", "url": "https://www.uniprot.org/uniprotkb/A0A0A0MPL5" } ], "pmid": "" }, { "name": "establishment or maintenance of cell polarity", "id": "GO:0007163", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007163", "evidence": [ { "database": "UniProtKB", "id": "A0A0A0MPL5", "url": "https://www.uniprot.org/uniprotkb/A0A0A0MPL5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein-macromolecule adaptor activity", "id": "GO:0030674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030674", "evidence": [ { "database": "UniProtKB", "id": "A0A0A0MPL5", "url": "https://www.uniprot.org/uniprotkb/A0A0A0MPL5" } ], "pmid": "" }, { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "A0A0A0MPL5", "url": "https://www.uniprot.org/uniprotkb/A0A0A0MPL5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 271, "end_pos": 273, "annotation": "n_glycosylation_sequon" }, { "start_pos": 34, "end_pos": 36, "annotation": "n_glycosylation_sequon" }, { "start_pos": 407, "end_pos": 409, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.agr", "label": "AGR Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 233, 236 ], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 271, "end_pos": 273 }, { "start_pos": 34, "end_pos": 36 }, { "start_pos": 407, "end_pos": 409 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_o_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }