{
    "uniprot_canonical_ac": "A0A097-1",
    "uniprot_ac": "A0A097",
    "uniprot_id": "A0A097_DANRE",
    "mass": {
        "chemical_mass": 5192.0,
        "monoisotopic_mass": 5192.0
    },
    "refseq": {
        "ac": "NP_001159390",
        "name": "thymosin beta 1",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159390"
    },
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        {
            "name": "tmsb1",
            "resource": "UniProtKB",
            "type": "recommended",
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            "id": "A0A097"
        },
        {
            "name": "Tbeta-a",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprotkb/A0A097",
            "id": "A0A097"
        },
        {
            "name": "fb15g10; si:dkey-152p16.6; tbeta-a; wu:fb15g10",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159390",
            "id": "NP_001159390"
        },
        {
            "name": "fb15g10",
            "resource": "UniProtKB",
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            "id": "A0A097"
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        {
            "name": "si:dkey-152p16.6",
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            "type": "synonym",
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            "id": "A0A097"
        },
        {
            "name": "tbeta-a",
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            "type": "synonym",
            "url": "https://www.uniprot.org/uniprotkb/A0A097",
            "id": "A0A097"
        },
        {
            "name": "tmsb1",
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            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159390",
            "id": "NP_001159390"
        },
        {
            "name": "wu:fb15g10",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprotkb/A0A097",
            "id": "A0A097"
        }
    ],
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        {
            "name": "Thymosin beta",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprotkb/A0A097/entry#names_and_taxonomy",
            "id": "A0A097"
        },
        {
            "name": "thymosin beta 1",
            "resource": "RefSeq",
            "type": "synonym",
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            "id": "NP_001159390"
        },
        {
            "name": "thymosin beta-a; beta thymosin-like protein 2; zTB1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159390",
            "id": "NP_001159390"
        }
    ],
    "function": [
        {
            "annotation": "##Evidence-Data-START## Transcript exon combination :: EH506469.1, EH503104.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH532625.1, EH506469.1 and BC142834.1.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001159390",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159390"
                }
            ]
        },
        {
            "annotation": "Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.",
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                    "id": "ARBA00025497",
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    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
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        },
        {
            "id": "ENSDARG00000104181",
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        },
        {
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        },
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            "id": "IPR001152",
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            "id": "IPR038386",
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        },
        {
            "id": "PTHR12021",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12021",
            "database": "PANTHER",
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                "Protein Classification"
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        },
        {
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            "database": "PANTHER",
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        },
        {
            "id": "PF01290",
            "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF01290",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_001159390",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159390",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A097",
            "url": "https://www.uniprot.org/uniprotkb/A0A097",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A097-1",
            "url": "https://www.uniprot.org/uniprotkb/A0A097-1",
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            "categories": [
                "Protein"
            ]
        },
        {
            "id": "ZDB-GENE-030131-8575",
            "url": "https://zfin.org/ZDB-GENE-030131-8575",
            "database": "ZFIN",
            "categories": [
                "Protein",
                "Organism-specific"
            ]
        }
    ],
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        "sequence": "MSDNPVKAEVQNFDKKCLKKTNTEEKNVLPTKEDIEQEKKAGEGAK",
        "length": 46,
        "header": "tr|A0A097-1|A0A097_DANRE Isoform 1 of Thymosin beta  OS=Danio rerio OX=7955 GN=tmsb1 PE=1 SV=1 CANONICAL=A0A097-1"
    },
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            "isoform_ac": "A0A097-1",
            "url": "https://www.uniprot.org/uniprotkb/A0A097/entry#A0A097-1",
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                "sequence": "MSDNPVKAEVQNFDKKCLKKTNTEEKNVLPTKEDIEQEKKAGEGAK",
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                "header": "tr|A0A097-1|A0A097_DANRE Isoform 1 of Thymosin beta  OS=Danio rerio OX=7955 GN=tmsb1 PE=1 SV=1 CANONICAL=A0A097-1"
            },
            "locus": {}
        }
    ],
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        {
            "glytoucan_ac": "G49108TO",
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            "prediction_tool_list": [],
            "site_category": "reported_with_glycan",
            "site_category_dict": {
                "reported_with_glycan": true
            },
            "site_seq": "",
            "relation": "attached",
            "comment": "O-GlcNAcylation",
            "evidence": [
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                    "id": "40044042",
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                    "url": "https://glygen.org/publication/PubMed/40044042"
                },
                {
                    "id": "A0A097",
                    "database": "O-GlcNAc Database",
                    "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A0A097"
                }
            ],
            "filter_code": "00000000000000000000.xxxxxxx.00000001000000.xxxxxxx.xxxxxxxxxx.xxxxxxxxxxxxxx.xxxxx.xxxxx"
        }
    ],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [
        "glycoprotein",
        "glycoprotein_reported_with_glycan"
    ],
    "publication": [
        {
            "title": "Vertebrate beta-thymosins: conserved synteny reveals the relationship between those of bony fish and of land vertebrates.",
            "journal": "FEBS Lett.",
            "date": "2010",
            "authors": "Edwards John",
            "evidence": [
                {
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                    "url": "https://www.uniprot.org/uniprotkb/A0A097"
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                {
                    "type": "PubMed",
                    "id": "20138884",
                    "url": "https://glygen.org/publication/PubMed/20138884"
                }
            ]
        },
        {
            "title": "The zebrafish reference genome sequence and its relationship to the human genome.",
            "journal": "Nature",
            "date": "2013",
            "authors": "Howe Kerstin, Clark Matthew D, Torroja Carlos F, Torrance James, Berthelot Camille, Muffato Matthieu, Collins John E, Humphray Sean, McLaren Karen, Matthews Lucy, McLaren Stuart, Sealy Ian, Caccamo Mario, Churcher Carol, Scott Carol, Barrett Jeffrey C, Koch Romke, Rauch Gerd-J\u00f6rg, White Simon, Chow William, Kilian Britt, Quintais Leonor T, Guerra-Assun\u00e7\u00e3o Jos\u00e9 A, Zhou Yi, Gu Yong, Yen Jennifer, Vogel Jan-Hinnerk, Eyre Tina, Redmond Seth, Banerjee Ruby, Chi Jianxiang, Fu Beiyuan, Langley Elizabeth, Maguire Sean F, Laird Gavin K, Lloyd David, Kenyon Emma, Donaldson Sarah, Sehra Harminder, Almeida-King Jeff, Loveland Jane, Trevanion Stephen, Jones Matt, Quail Mike, Willey Dave, Hunt Adrienne, Burton John, Sims Sarah, McLay Kirsten, Plumb Bob, Davis Joy, Clee Chris, Oliver Karen, Clark Richard, Riddle Clare, Elliot David, Eliott David, Threadgold Glen, Harden Glenn, Ware Darren, Begum Sharmin, Mortimore Beverley, Mortimer Beverly, Kerry Giselle, Heath Paul, Phillimore Benjamin, Tracey Alan, Corby Nicole, Dunn Matthew, Johnson Christopher, Wood Jonathan, Clark Susan, Pelan Sarah, Griffiths Guy, Smith Michelle, Glithero Rebecca, Howden Philip, Barker Nicholas, Lloyd Christine, Stevens Christopher, Harley Joanna, Holt Karen, Panagiotidis Georgios, Lovell Jamieson, Beasley Helen, Henderson Carl, Gordon Daria, Auger Katherine, Wright Deborah, Collins Joanna, Raisen Claire, Dyer Lauren, Leung Kenric, Robertson Lauren, Ambridge Kirsty, Leongamornlert Daniel, McGuire Sarah, Gilderthorp Ruth, Griffiths Coline, Manthravadi Deepa, Nichol Sarah, Barker Gary, Whitehead Siobhan, Kay Michael, Brown Jacqueline, Murnane Clare, Gray Emma, Humphries Matthew, Sycamore Neil, Barker Darren, Saunders David, Wallis Justene, Babbage Anne, Hammond Sian, Mashreghi-Mohammadi Maryam, Barr Lucy, Martin Sancha, Wray Paul, Ellington Andrew, Matthews Nicholas, Ellwood Matthew, Woodmansey Rebecca, Clark Graham, Cooper James  D, Cooper James, Tromans Anthony, Grafham Darren, Skuce Carl, Pandian Richard, Andrews Robert, Harrison Elliot, Kimberley Andrew, Garnett Jane, Fosker Nigel, Hall Rebekah, Garner Patrick, Kelly Daniel, Bird Christine, Palmer Sophie, Gehring Ines, Berger Andrea, Dooley Christopher M, Ersan-\u00dcr\u00fcn Z\u00fcbeyde, Eser Cigdem, Geiger Horst, Geisler Maria, Karotki Lena, Kirn Anette, Konantz Judith, Konantz Martina, Oberl\u00e4nder Martina, Rudolph-Geiger Silke, Teucke Mathias, Lanz Christa, Raddatz G\u00fcnter, Osoegawa Kazutoyo, Zhu Baoli, Rapp Amanda, Widaa Sara, Langford Cordelia, Yang Fengtang, Schuster Stephan C, Carter Nigel P, Harrow Jennifer, Ning Zemin, Herrero Javier, Searle Steve M J, Enright Anton, Geisler Robert, Plasterk Ronald H A, Lee Charles, Westerfield Monte, de Jong Pieter J, Zon Leonard I, Postlethwait John H, N\u00fcsslein-Volhard Christiane, Hubbard Tim J P, Roest Crollius Hugues, Rogers Jane, Stemple Derek L",
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            ]
        },
        {
            "title": "Thymosin beta4 regulates cardiac valve formation via endothelial-mesenchymal transformation in zebrafish embryos.",
            "journal": "Mol. Cells",
            "date": "2014",
            "authors": "Shin Sun-Hye, Lee Sangkyu, Bae Jong-Sup, Jee Jun-Goo, Cha Hee-Jae, Lee You Mie",
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                    "type": "PubMed",
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            ]
        },
        {
            "title": "Characterization of two thymosins as immune-related genes in common carp (Cyprinus carpio L.).",
            "journal": "Dev. Comp. Immunol.",
            "date": "2015",
            "authors": "Xiao Zhangang, Shen Jing, Feng Hong, Liu Hong, Wang Yaping, Huang Rong, Guo Qionglin",
            "evidence": [
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            ]
        },
        {
            "title": "Protein Arginine Methyltransferase 6 (Prmt6) Is Essential for Early Zebrafish Development through the Direct Suppression of gadd45alphaa Stress Sensor Gene.",
            "journal": "J. Biol. Chem.",
            "date": "2016",
            "authors": "Zhao Xin-Xi, Zhang Yun-Bin, Ni Pei-Li, Wu Zhi-Li, Yan Yuan-Chang, Li Yi-Ping",
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        {
            "title": "Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.",
            "journal": "BMC Genomics",
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            "authors": "Pasquier Jeremy, Cabau C\u00e9dric, Nguyen Thaovi, Jouanno Elodie, Severac Dany, Braasch Ingo, Journot Laurent, Pontarotti Pierre, Klopp Christophe, Postlethwait John H, Guiguen Yann, Bobe Julien",
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        {
            "title": "scRNA Transcription Profile of Adult Zebrafish Podocytes Using a Novel Reporter Strain.",
            "journal": "Cell. Physiol. Biochem.",
            "date": "2021",
            "authors": "Brown Cara, Mullins Linda J, Wesencraft Katrina, McConnell Gail, Beltran Mariana, Henderson Neil C, Conway Bryan, Hoffmann Scott, Rider Sebastian, Mullins John J",
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        {
            "title": "Unraveling Differential Transcriptomes and Cell Types in Zebrafish Larvae Intestine and Liver.",
            "journal": "Cells",
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            "authors": "Gao Yuqi, Jin Qingxia, Gao Ce, Chen Yayue, Sun Zhaoxiang, Guo Guoji, Peng Jinrong",
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        },
        {
            "title": "Upregulation of Protein O-GlcNAcylation Levels Promotes Zebrafish Fin Regeneration.",
            "journal": "Molecular & cellular proteomics : MCP",
            "date": "2025-04",
            "authors": "Jia Liyuan, Zheng Hanxue, Feng Juantao, Ding Yi, Sun Xiaotian, Yu Yuan, Hao Xue, Wang Junxiang, Zhang Xinyu, Tian Yuanfeng, Chen Fulin, Cui Jihong",
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        {
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        {
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            ],
            "glygen_name": "Mouse",
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "A2AF33-1",
            "protein_name": "Thymosin beta",
            "gene_name": "Tmsb15b1",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MSDKPDLSEVETFDKSKLKKTNTEVKNTLPSNETIQQEKEHNERT",
                "length": 45
            },
            "evidence": [
                {
                    "id": "ZFIN:ZDB-GENE-030131-8575",
                    "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-030131-8575#orthology",
                    "database": "AGR"
                },
                {
                    "id": "RGD:708373",
                    "url": "https://alliancegenome.org/gene/RGD:708373#orthology",
                    "database": "AGR"
                },
                {
                    "id": "MGI:3843059",
                    "url": "https://alliancegenome.org/gene/MGI:3843059#orthology",
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                }
            ],
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            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "O97428-1",
            "protein_name": "Ciboulot, isoform E",
            "gene_name": "cib",
            "tax_id": 7227,
            "organism": "Drosophila melanogaster",
            "sequence": {
                "sequence": "MAAPAPALKDLPKVAENLKSQLEGFNQDKLKNASTQEKIILPTAEDVAAEKTQQSIFEGITAFNQNNLKHTETNEKNPLPDKEAIEQEKEKNQFIAGIENFDAKKLKHTETNEKNVLPTKEVIEAEKQA",
                "length": 129
            },
            "evidence": [
                {
                    "id": "MGI:3843061",
                    "url": "https://alliancegenome.org/gene/MGI:3843061#orthology",
                    "database": "AGR"
                }
            ],
            "glygen_name": "Fruit fly",
            "common_name": "Fruit fly"
        },
        {
            "uniprot_canonical_ac": "P0CG34-1",
            "protein_name": "Thymosin beta-15A",
            "gene_name": "TMSB15A",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MSDKPDLSEVEKFDRSKLKKTNTEEKNTLPSKETIQQEKECVQTS",
                "length": 45
            },
            "evidence": [
                {
                    "id": "MGI:3843061",
                    "url": "https://alliancegenome.org/gene/MGI:3843061#orthology",
                    "database": "AGR"
                },
                {
                    "id": "RGD:708373",
                    "url": "https://alliancegenome.org/gene/RGD:708373#orthology",
                    "database": "AGR"
                },
                {
                    "id": "RGD:2324583",
                    "url": "https://alliancegenome.org/gene/RGD:2324583#orthology",
                    "database": "AGR"
                },
                {
                    "id": "MGI:3843059",
                    "url": "https://alliancegenome.org/gene/MGI:3843059#orthology",
                    "database": "AGR"
                }
            ],
            "glygen_name": "Human",
            "common_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P0CG35-1",
            "protein_name": "Thymosin beta-15B",
            "gene_name": "TMSB15B",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MSDKPDLSEVEKFDRSKLKKTNTEEKNTLPSKETIQQEKECVQTS",
                "length": 45
            },
            "evidence": [
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                    "id": "MGI:3843061",
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                },
                {
                    "id": "RGD:2324583",
                    "url": "https://alliancegenome.org/gene/RGD:2324583#orthology",
                    "database": "AGR"
                },
                {
                    "id": "MGI:3843059",
                    "url": "https://alliancegenome.org/gene/MGI:3843059#orthology",
                    "database": "AGR"
                }
            ],
            "glygen_name": "Human",
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 1,
                "go_terms": [
                    {
                        "name": "actin monomer binding",
                        "id": "GO:0003785",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003785",
                        "evidence": [
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                                "database": "UniProtKB",
                                "id": "A0A097",
                                "url": "https://www.uniprot.org/uniprotkb/A0A097"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 2,
                "go_terms": [
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A097",
                                "url": "https://www.uniprot.org/uniprotkb/A0A097"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytoskeleton",
                        "id": "GO:0005856",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856",
                        "evidence": [
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                                "database": "UniProtKB",
                                "id": "A0A097",
                                "url": "https://www.uniprot.org/uniprotkb/A0A097"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 2,
                "go_terms": [
                    {
                        "name": "actin filament organization",
                        "id": "GO:0007015",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007015",
                        "evidence": [
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                                "database": "UniProtKB",
                                "id": "A0A097",
                                "url": "https://www.uniprot.org/uniprotkb/A0A097"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of cell migration",
                        "id": "GO:0030334",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030334",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A097",
                                "url": "https://www.uniprot.org/uniprotkb/A0A097"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "structures": [],
    "synthesized_glycans": [],
    "enzyme_annotation": [],
    "cluster_types": [
        {
            "name": "homologset.agr",
            "label": "AGR Homologs"
        }
    ],
    "sequence_features": {
        "n_linked_sites": [],
        "o_linked_sites": [],
        "snv_sites": [],
        "glycation_sites": [],
        "phosphorylation_sites": [],
        "sequon_annotation_sites": []
    },
    "section_stats": [
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                },
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                    "field": "n_linked_glycan_sites",
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}
