{ "uniprot_canonical_ac": "A0A087WPC3-1", "uniprot_ac": "A0A087WPC3", "uniprot_id": "A0A087WPC3_MOUSE", "mass": { "chemical_mass": 58594.0, "monoisotopic_mass": 58594.0 }, "refseq": { "ac": "NP_001093653", "name": "cytochrome P450, family 4, subfamily a, polypeptide 29", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093653" }, "gene_names": [ { "name": "Cyp4a29", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A087WPC3", "id": "A0A087WPC3" }, { "name": "Cyp4a29-ps", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093653", "id": "NP_001093653" }, { "name": "Cyp4a29", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093653", "id": "NP_001093653" } ], "protein_names": [ { "name": "Cytochrome P450, family 4, subfamily a, polypeptide 29", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A087WPC3/entry#names_and_taxonomy", "id": "A0A087WPC3" }, { "name": "cytochrome P450, family 4, subfamily a, polypeptide 29, pseudogene", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093653", "id": "NP_001093653" }, { "name": "cytochrome P450, family 4, subfamily a, polypeptide 29", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093653", "id": "NP_001093653" } ], "function": [], "disease": [ { "disease_id": "DOID:10763", "recommended_name": { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "hypertension", "description": "An artery disease characterized by chronic elevated blood pressure in the arteries." }, "synonyms": [ { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "HTN", "description": "" }, { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "hyperpiesia", "description": "" }, { "id": "DOID:10763", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10763", "name": "vascular hypertensive disorder", "description": "" } ], "unlinked_id_list": [ "DOID:11130" ], "evidence": [ { "id": "10763", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:10763" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A0A087WPC3", "url": "https://www.uniprot.org/uniprotkb/A0A087WPC3" } ], "common_name": "Mouse", "glygen_name": "Mouse", "reference_species": "Mus musculus [10090]" } ], "gene": [ { "name": "Cyp4a29", "url": "https://www.uniprot.org/uniprotkb/A0A087WPC3", "locus": { "chromosome": "4", "start_pos": 115111754, "end_pos": 115099281, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000083138", "url": "https://www.ensembl.org/id/ENSMUSG00000083138" } ] } } ], "crossref": [ { "id": "MGI:3717143", "url": "https://alliancegenome.org/gene/MGI:3717143", "database": "AGR", "categories": [ "Protein Classification" ] }, { "id": "A0A087WPC3", "url": "https://alphafold.ebi.ac.uk/entry/A0A087WPC3", "database": "AlphaFoldDB", "categories": [] }, { "id": "ENSMUSG00000083138", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000083138", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd20678", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20678", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "230639", "url": "https://www.ncbi.nlm.nih.gov/gene/230639", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001128", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001128", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002401", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002401", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017972", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017972", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036396", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036396", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR050196", "url": "https://www.ebi.ac.uk/interpro/entry/IPR050196", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:230639", "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:230639", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "3717143", "url": "http://www.informatics.jax.org/marker/MGI:3717143", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "RNPFHHN", "url": "https://omabrowser.org/oma/group/RNPFHHN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "A0A087WPC3", "url": "https://www.orthodb.org/?gene=A0A087WPC3", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24291", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24291", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24291:SF165", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24291:SF165", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00067", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF00067", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-211935", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-211935", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-211958", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-211958", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-211979", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-211979", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-2142691", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2142691", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001093653", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093653", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A087WPC3", "url": "https://www.uniprot.org/uniprotkb/A0A087WPC3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A087WPC3-1", "url": "https://www.uniprot.org/uniprotkb/A0A087WPC3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSISALSPIRFLECVSGFLQVIFLIGLLLLLFKAAQHYLRRQWLLRALYQFPSPPSHWLFGHCLQFKVDEELRWILRYLEKFPGAFLHWIWGSHVFIKVCDPDYMKVILGRADPKASLYRFLTPWLGHGLFFLNGDEWFQHRRLLTPAFHYDILKPYVGIMADSVQVMLEKWEQIACQDITLEIFHPISLMMLDTIMKYAFSYQGSVQLDRSSQAYLQAVSDLNNLVTSRMKNVFLHNDIIYNLTSHSRRTNSACQIAHEHTDRVVKLRKAQLQDNKSMKKLRGKRCLDFLDILLLSRMDDGSSLSDKALRAEVDSLMFGGHDTPASGISWVFYALATHPDHQQRCREEVQSLLGDGSPITWDHLHQMPYTTMCIKEALRLYPPIPSVGRKLSTPVTFPDGRSLPKGITVLLHFYALHHNPKVWPNPEVFDPSRFAMNSVQHSHAFLPFSGGSRNCIGKHLAMNVLKVAVALTLLRFELLPDPSRVPIPTQQLVLKSKNGIYLHLRKLQ", "length": 509, "header": "tr|A0A087WPC3-1|A0A087WPC3_MOUSE Isoform 1 of Cytochrome P450, family 4, subfamily a, polypeptide 29 OS=Mus musculus OX=10090 GN=Cyp4a29 PE=3 SV=1 CANONICAL=A0A087WPC3-1" }, "isoforms": [ { "isoform_ac": "A0A087WPC3-1", "url": "https://www.uniprot.org/uniprotkb/A0A087WPC3/entry#A0A087WPC3-1", "sequence": { "sequence": "MSISALSPIRFLECVSGFLQVIFLIGLLLLLFKAAQHYLRRQWLLRALYQFPSPPSHWLFGHCLQFKVDEELRWILRYLEKFPGAFLHWIWGSHVFIKVCDPDYMKVILGRADPKASLYRFLTPWLGHGLFFLNGDEWFQHRRLLTPAFHYDILKPYVGIMADSVQVMLEKWEQIACQDITLEIFHPISLMMLDTIMKYAFSYQGSVQLDRSSQAYLQAVSDLNNLVTSRMKNVFLHNDIIYNLTSHSRRTNSACQIAHEHTDRVVKLRKAQLQDNKSMKKLRGKRCLDFLDILLLSRMDDGSSLSDKALRAEVDSLMFGGHDTPASGISWVFYALATHPDHQQRCREEVQSLLGDGSPITWDHLHQMPYTTMCIKEALRLYPPIPSVGRKLSTPVTFPDGRSLPKGITVLLHFYALHHNPKVWPNPEVFDPSRFAMNSVQHSHAFLPFSGGSRNCIGKHLAMNVLKVAVALTLLRFELLPDPSRVPIPTQQLVLKSKNGIYLHLRKLQ", "length": 509, "header": "tr|A0A087WPC3-1|A0A087WPC3_MOUSE Isoform 1 of Cytochrome P450, family 4, subfamily a, polypeptide 29 OS=Mus musculus OX=10090 GN=Cyp4a29 PE=3 SV=1 CANONICAL=A0A087WPC3-1" }, "locus": { "chromosome": "4", "start_pos": 115111751, "end_pos": 115099281, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000118278.2", "url": "https://www.ensembl.org/id/ENSMUST00000118278.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000139717.2", "url": "https://www.ensembl.org/id/ENSMUSP00000139717.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Modernizing reference genome assemblies.", "journal": "PLoS Biol.", "date": "2011", "authors": "Church Deanna M, Schneider Valerie A, Graves Tina, Auger Katherine, Cunningham Fiona, Bouk Nathan, Chen Hsiu-Chuan, Agarwala Richa, McLaren William M, Ritchie Graham R S, Albracht Derek, Kremitzki Milinn, Rock Susan, Kotkiewicz Holland, Kremitzki Colin, Wollam Aye, Trani Lee, Fulton Lucinda, Fulton Robert, Matthews Lucy, Whitehead Siobhan, Chow Will, Torrance James, Dunn Matthew, Harden Glenn, Threadgold Glen, Wood Jonathan, Collins Joanna, Heath Paul, Griffiths Guy, Pelan Sarah, Grafham Darren, Eichler Evan E, Weinstock George, Mardis Elaine R, Wilson Richard K, Howe Kerstin, Flicek Paul, Hubbard Tim", "evidence": [ { "database": "UniProtKB", "id": "A0A087WPC3", "url": "https://www.uniprot.org/uniprotkb/A0A087WPC3" } ], "reference": [ { "type": "PubMed", "id": "21750661", "url": "https://glygen.org/publication/PubMed/21750661" } ] } ], "pathway": [ { "id": "mmu:230639", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?mmu:230639", "resource": "KEGG Pathway" }, { "id": "R-MMU-211935", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-211935", "resource": "Reactome", "description": "Fatty acids" }, { "id": "R-MMU-211958", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-211958", "resource": "Reactome", "description": "Miscellaneous substrates" }, { "id": "R-MMU-211979", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-211979", "resource": "Reactome", "description": "Eicosanoids" }, { "id": "R-MMU-2142691", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2142691", "resource": "Reactome", "description": "Synthesis of Leukotrienes (LT) and Eoxins (EX)" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A087WS15-1", "protein_name": "Cytochrome P450, family 4, subfamily a, polypeptide 30b", "gene_name": "Cyp4a30b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSIFELSHITNVFGIFGLLQVVSLLGLLLLLLKSAQYYLHRQWLIKSLQQFPPAPPPQWLFGNTLKDQDLQQILLCVEKFPSTYVRWLWGNHARVVIYDPDYMKVILGRSDPKVVRSYSFFAPWIGYGLLLLNGKKWFQHRRMLTPAFHYDILKPYVGIMVDSVHVMLDKWEQLVDQDCPLEIYQDISLMTMETMMKCAFSYQGSVQLEENSKSYIKAVEDLTHLIYLRVRNGFHQNNTIYSLSSNGRSFYHACQIAHKHTERVIRMRKAQLQNEAELEKFRKKKRLDFLDILLFAQTEDGKSLSDEDVRAEMDTFMFEGHNTTASGISWIFYALATHPEHQQRCREEVKSILGNGTSVTLNHLDQMPYTTMCIKEALRLYPPIPGASRELSSPVTFPDGCSLPKGFLVTLSFYGLHHNPRLRPNAEVFDPSRFAPGAPRQTHAFLPFSAGTRNCIGKQFTMNELKVAVALTLLRFELLPDPTRVPILVSKIVLKSKNGIYLHTKKLK", "length": 508 }, "evidence": [ { "id": "HGNC:20575", "url": "https://alliancegenome.org/gene/HGNC:20575#orthology", "database": "AGR" }, { "id": "HGNC:2642", "url": "https://alliancegenome.org/gene/HGNC:2642#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2A8T1-1", "protein_name": "Cytochrome P450, family 4, subfamily a, polypeptide 32", "gene_name": "Cyp4a32", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSVSALSPTRFADSLSGFLQVASVLGLLLLLVKAVQFYLHRKWLLKALQQFPSPPFHWFFGHEQFKGEQELKEVVSCIEHFPSAFPCWFWGSNAYLTVYDPDYMKVILGRSDPKANGIYRLLAPWIGYGLLLLNGQPWFQHRRMLTPAFHYDILKPYVKNMADSIRLMLDKWERLAGQDSSIEIFQHISLMTLDTVMKCAFSHKGSVQVDGNYKTYLQAIGDLNNLFHSRVRNIFHQNDTIYRLSSNGRLAKQACQLAHDHTDGVIKMRKDQLQDEGELENIKKKRRLDFLDILLFARMENGDSMSDKDLRAEVDTFMFEGHDTTASGVSWIFYALATHPEHQQRCREEVQSLLGDGSSITWDHLDQIPYTTMCIKEALRLYPPVPGIVRELSTSVTFPDGRSLPKGVQVTLSIYGLHHNPKVWPNPEVFDPSRFAPDSPRHSHSFLPFSGGARNCIGKQFAMSELKVIVALTLLHFELLPDPTRVPEPLARIVLKSKNGIYLHLKKLH", "length": 509 }, "evidence": [ { "id": "HGNC:20575", "url": "https://alliancegenome.org/gene/HGNC:20575#orthology", "database": "AGR" }, { "id": "HGNC:2642", "url": "https://alliancegenome.org/gene/HGNC:2642#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "A2A974-1", "protein_name": "Cytochrome P450 4A12B", "gene_name": "Cyp4a12b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSASALSSIRFPGSISEYLQVASVLSLLLLLFKTAQLYLHRQWLLSSTQQFPSPPSHWLFGHKILKDQDLQDILTRIKNFPSACPQWLWGSKVRIQVYDPDYMKLILGRSDPKAHGSYRFLAPWIGRGLLLLDGQTWFQHRRMLTPAFHYDILKPYTEIMADSVHVMLDKWEQIVGQDSTLEIFQHITLMTLDTIMKCAFSHEGSVQLDRKYKSYIQAVEDLNNLFFLRVRNIFHQNDIIYRVSSNGCLANSACQLAHDHTDQVIKSRRSQLQDEEELEKLKKKRRLDFLDILLFARMENGKSLSDKDLRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQRCRKEIQSLLGDGASITWNDLDKMPYTTMCIKEALRIYPPVPSVSRELSSPVTFPDGRSLPKGIHVMLSFYGLHHNPTVWPNPEVFDPSRFAPGSSRHSHSFLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRVPIPIPRIVLKSKNGIHLHLKKLQ", "length": 508 }, "evidence": [ { "id": "HGNC:20575", "url": "https://alliancegenome.org/gene/HGNC:20575#orthology", "database": "AGR" }, { "id": "HGNC:2642", "url": "https://alliancegenome.org/gene/HGNC:2642#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "F8WGU9-1", "protein_name": "Cytochrome P450, family 4, subfamily a, polypeptide 31", "gene_name": "Cyp4a31", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSVSALSLTRFAGSLSGFLQVASVFCLLLLLVKAVQVYLHRKWLLKALQQFPSPPFHWFFGHEQFKGDQELQEIVSCIENFPSAFPRWFWGSKAYLTVYDPDYMKVILGRSDPKANGAYRLLAPWIGYGLLLLNGQSWFQHRKMLTPAFHYDILKTYVKNMADSIRLMLDKWERLAGQDSSIEIFQHISLMTLDTVMKCAFSHKGSVQVDGNYKTYLQAIGDLNNLVHSRVRNMFHQNDTIYKLSSNGRLSNQACQLAHDHTDGVIKMRKDQLQDEGELENIKKKRRLDFLDILLFARMENEDSMSDKDLRAEVDTFMIEGHDTTASGVSWIFYALATHPEHQQRCREEVQSLLGDGSSITWDHLDQIPYTTMCIKEALRLYPPVPSIGRELSTSVTFPDGCSLPKGVQVTLSIYGLHHNPKVWPNPEVFDPSRFAPDSPRHSHSFLPFSGGARNCIGKQFAMSELKVIVALTLLRFELLPDPTRVPMSLARFVLKSKNGIYLHLKKVH", "length": 509 }, "evidence": [ { "id": "HGNC:20575", "url": "https://alliancegenome.org/gene/HGNC:20575#orthology", "database": "AGR" }, { "id": "HGNC:2642", "url": "https://alliancegenome.org/gene/HGNC:2642#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "O35728-1", "protein_name": "Cytochrome P450 4A14", "gene_name": "Cyp4a14", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGFFLFSPTRYLDGISGFFQWAFLLSLFLVLFKAVQFYLRRQWLLKTLQHFPCMPSHWLWGHHLKDKELQQILIWVEKFPSACLQCLSGSNIRVLLYDPDYVKVVLGRSDPKASGIYQFFAPWIGYGLLLLNGKKWFQHRRMLTPAFHYDILKPYVKIMADSVNIMLDKWEKLDGQDHPLEIFHCVSLMTLDTVMKCAFSYQGSVQLDENSKLYTKAVEDLNNLTFFRLRNAFYKYNIIYNMSSDGRLSHHACQIAHEHTDGVIKMRKSQLQNEEELQKARKKRHLDFLDILLFARMEDRNSLSDEDLRAEVDTFMFEGHDTTASGISWIFYALATHPEHQQRCREEVQSILGDGTSVTWDHLGQMPYTTMCIKEALRLYPPVISVSRELSSPVTFPDGRSIPKGITATISIYGLHHNPRFWPNPKVFDPSRFAPDSSHHSHAYLPFSGGSRNCIGKQFAMNELKVAVALTLLRFELLPDPTRIPVPIARLVLKSKNGIHLCLKKLR", "length": 507 }, "evidence": [ { "id": "HGNC:20575", "url": "https://alliancegenome.org/gene/HGNC:20575#orthology", "database": "AGR" }, { "id": "HGNC:2642", "url": "https://alliancegenome.org/gene/HGNC:2642#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "O88833-1", "protein_name": "Cytochrome P450 4A10", "gene_name": "Cyp4a10", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSVSALSPTRFADSLSGFLQVASVLGLLLLLVKAVQFYLHRQWLLKAFQQFPSPPFHWFFGHEKFKGDQELQEIVSCIENFPSAFPRWFWGSKAYLTVYDPDYMKVILGRSDPKANGAYRLLAPWIGYGLLLLNGQPWFQHRRMLTPAFHYDILKPYVKNMADSIRLMLDKWERLADQDSSIEIFQHISLMTLDTVMKCAFSHKGSVQVDGNYRTYLQAIGDLNNLFHSRVRNIFHQNDTIYKLSSNGRLAKQACQLAHDHTDGVIKLRKDQLQDEGELEKIKKKRRLDFLDILLFARMENGDSMSDKDLRAEVDTFMFEGHDTTASGVSWIFYALATHPDHQQRCREEVQSLLGDGSSITWDHLDQIPYTTMCIKEALRLYPPVPGIVRELSTSVTFPDGRSLPKGVQVTLSIYGLHHNPKVWPNPEVFDPSRFAPDSPRHSHSFLPFSGGARNCIGKQFAMSELKVIVALTLLRFELLPDPTRVPMPLARLVLKSKNGIYLHLKKLH", "length": 509 }, "evidence": [ { "id": "HGNC:20575", "url": "https://alliancegenome.org/gene/HGNC:20575#orthology", "database": "AGR" }, { "id": "HGNC:2642", "url": "https://alliancegenome.org/gene/HGNC:2642#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "P08516-1", "protein_name": "Cytochrome P450 4A10", "gene_name": "Cyp4a10", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSVSALSSTRFTGSISGFLQVASVLGLLLLLVKAVQFYLQRQWLLKAFQQFPSPPFHWFFGHKQFQGDKELQQIMTCVENFPSAFPRWFWGSKAYLIVYDPDYMKVILGRSDPKANGVYRLLAPWIGYGLLLLNGQPWFQHRRMLTPAFHYDILKPYVKNMADSIRLMLDKWEQLAGQDSSIEIFQHISLMTLDTVMKCAFSHNGSVQVDGNYKSYIQAIGNLNDLFHSRVRNIFHQNDTIYNFSSNGHLFNRACQLAHDHTDGVIKLRKDQLQNAGELEKVKKKRRLDFLDILLLARMENGDSLSDKDLRAEVDTFMFEGHDTTASGVSWIFYALATHPEHQQRCREEVQSVLGDGSSITWDHLDQIPYTTMCIKEALRLYPPVPGIVRELSTSVTFPDGRSLPKGIQVTLSIYGLHHNPKVWPNPEVFDPSRFAPDSPRHSHSFLPFSGGARNCIGKQFAMSEMKVIVALTLLRFELLPDPTKVPIPLPRLVLKSKNGIYLYLKKLH", "length": 509 }, "evidence": [ { "id": "HGNC:20575", "url": "https://alliancegenome.org/gene/HGNC:20575#orthology", "database": "AGR" }, { "id": "HGNC:2642", "url": "https://alliancegenome.org/gene/HGNC:2642#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P20816-1", "protein_name": "Cytochrome P450 4A2", "gene_name": "Cyp4a2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGFSVFSPTRSLDGVSGFFQGAFLLSLFLVLFKAVQFYLRRQWLLKALEKFPSTPSHWLWGHNLKDREFQQVLTWVEKFPGACLQWLSGSTARVLLYDPDYVKVVLGRSDPKPYQSLAPWIGYGLLLLNGKKWFQHRRMLTPAFHYDILKPYVKIMADSVSIMLDKWEKLDDQDHPLEIFHYVSLMTLDTVMKCAFSHQGSVQLDVNSRSYTKAVEDLNNLIFFRVRSAFYGNSIIYNMSSDGRLSRRACQIAHEHTDGVIKTRKAQLQNEEELQKARKKRHLDFLDILLFAKMEDGKSLSDEDLRAEVDTFMFEGHDTTASGISWVFYALATHPEHQERCREEVQSILGDGTSVTWDHLDQMPYTTMCIKEALRLYSPVPSVSRELSSPVTFPDGRSIPKGIRVTILIYGLHHNPSYWPNPKVFDPSRFSPDSPRHSHAYLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRIPVPMPRLVLKSKNGIHLRLKKLR", "length": 504 }, "evidence": [ { "id": "HGNC:20575", "url": "https://alliancegenome.org/gene/HGNC:20575#orthology", "database": "AGR" }, { "id": "HGNC:2642", "url": "https://alliancegenome.org/gene/HGNC:2642#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P20817-1", "protein_name": "Cytochrome P450 4A14", "gene_name": "Cyp4a14", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGFSVFTPTRSLDGVSGFFQGAFLLSLFLVLFKAVQFYLRRQWLLKALEKFPSTPSHWLWGHDLKDREFQQVLTWVEKFPGACLQWLSGSKTRVLLYDPDYVKVVLGRSDPKASGIYQFLAPWIGYGLLLLNGKKWFQHRRMLTPAFHYGILKPYVKIMADSVNIMLDKWEKLDDQDHPLEIFHYVSLMTLDTVMKCAFSHQGSVQLDVNSRSYTKAVEDLNNLTFFRVRSAFYGNSIIYNMSSDGRLSRRACQIAHEHTDGVIKMRKAQLQNEEELQKARKKRHLDFLDILLFAKMEDGKSLSDEDLRAEVDTFMFEGHDTTASGISWVFYALATHPEHQERCREEVQSILGDGTSVTWDHLDQIPYTTMCIKEALRLYPPVPSVSRELSSPVTFPDGRSIPKGITTTILIYGLHHNPSYWPNPKVFDPSRFSPDSPRHSHAYLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRIPVPMARLVLKSKNGIHLRLKKLR", "length": 507 }, "evidence": [ { "id": "HGNC:20575", "url": "https://alliancegenome.org/gene/HGNC:20575#orthology", "database": "AGR" }, { "id": "HGNC:2642", "url": "https://alliancegenome.org/gene/HGNC:2642#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P24464-1", "protein_name": "Cytochrome P450 4A12", "gene_name": "Cyp4a12", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSGSALSFTIFPGSILGFLQIATVLTVLLLLFKTAQFYLHRRWLLRATQQFPSPPSHWFFGHKIPKDQEFQDILTRVKNFPSACPQWLWGSNVRIQVYDPDYMKLILGRSDPKSHHSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDTLKPYVGIMADSVRIMLDKWEQIVGQDSTLEIFQHITLMTLDTIMKCAFSQEGSVQLDRKYKSYIKAVEDLNNLSFFRIRNIFHQNDIIYSLSSNGRKARSAWQLAHEHTDQVIKSRKAQLQDEEELQKVKQKRRLDFLDILLFARIENGSSLSDKDLRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQGCRKEIQSLLGDGASITWDDLDKMPYTTMCIKEALRIYPPVTAVSRMLSTPVTFPDGRSLPKGITVMLSFYGLHHNPTVWPNPEVFDPYRFAPESSRHSHSFLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRIPIPIPRLVLKSKNGIYLRLKKLQ", "length": 508 }, "evidence": [ { "id": "HGNC:20575", "url": "https://alliancegenome.org/gene/HGNC:20575#orthology", "database": "AGR" }, { "id": "HGNC:2642", "url": "https://alliancegenome.org/gene/HGNC:2642#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "Q02928-1", "protein_name": "Cytochrome P450 4A11", "gene_name": "CYP4A11", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSVSVLSPSRLLGDVSGILQAASLLILLLLLIKAVQLYLHRQWLLKALQQFPCPPSHWLFGHIQELQQDQELQRIQKWVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLPDPTRIPIPIARLVLKSKNGIHLRLRRLPNPCEDKDQL", "length": 519 }, "evidence": [ { "id": "MGI:3717143", "url": "https://alliancegenome.org/gene/MGI:3717143#orthology", "database": "AGR" }, { "id": "HGNC:2642", "url": "https://alliancegenome.org/gene/HGNC:2642#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5TCH4-1", "protein_name": "Cytochrome P450 4A22", "gene_name": "CYP4A22", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSVSVLSPSRRLGGVSGILQVTSLLILLLLLIKAAQLYLHRQWLLKALQQFPCPPSHWLFGHIQEFQHDQELQRIQERVKTFPSACPYWIWGGKVRVQLYDPDYMKVILGRSDPKSHGSYKFLAPRIGYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKSAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLPDPTRIPIPMARLVLKSKNGIHLRLRRLPNPCEDKDQL", "length": 519 }, "evidence": [ { "id": "MGI:3717143", "url": "https://alliancegenome.org/gene/MGI:3717143#orthology", "database": "AGR" }, { "id": "HGNC:20575", "url": "https://alliancegenome.org/gene/HGNC:20575#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q91WL5-1", "protein_name": "Cytochrome P450 4A12A", "gene_name": "Cyp4a12a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSASALSSIRFPGSISEYLQVASVLSLLLLLFKTAQLYLHRQWLLSSTQQFPSPPSHWLFGHKILKDQDLQDILTRIKNFPSACPQWLWGSKVRIQVYDPDYMKLILGRSDPKANGSYRFLAPWIGRGLLMLDGQTWFQHRRMLTPAFHYDILKPYTEIMADSVRVMLDKWEQIVGQDSTLEIFRHITLMTLDTIMKCAFSHEGSVQLDRKYKSYIQAVEDLNDLVFSRVRNIFHQNDIIYRVSSNGCKANSACKLAHDHTDQVIKSRRIQLQDEEELEKLKKKRRLDFLDILLFARMENGKSLSDKDLRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQRCRKEIQSLLGDGTSITWNDLDKMPYTTMCIKEALRIYPPVPSVSRELSSPVTFPDGRSLPKGIHVMLSFYGLHHNPTVWPNPEVFDPSRFAPGSSRHSHSFLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRVPIPIPRIVLKSKNGIHLHLKKLQ", "length": 508 }, "evidence": [ { "id": "HGNC:20575", "url": "https://alliancegenome.org/gene/HGNC:20575#orthology", "database": "AGR" }, { "id": "HGNC:2642", "url": "https://alliancegenome.org/gene/HGNC:2642#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "iron ion binding", "id": "GO:0005506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", "evidence": [ { "database": "UniProtKB", "id": "A0A087WPC3", "url": "https://www.uniprot.org/uniprotkb/A0A087WPC3" } ], "pmid": "" }, { "name": "heme binding", "id": "GO:0020037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020037", "evidence": [ { "database": "UniProtKB", "id": "A0A087WPC3", "url": "https://www.uniprot.org/uniprotkb/A0A087WPC3" } ], "pmid": "" }, { "name": "monooxygenase activity", "id": "GO:0004497", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004497", "evidence": [ { "database": "UniProtKB", "id": "A0A087WPC3", "url": "https://www.uniprot.org/uniprotkb/A0A087WPC3" } ], "pmid": "" }, { "name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "id": "GO:0016705", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016705", "evidence": [ { "database": "UniProtKB", "id": "A0A087WPC3", "url": "https://www.uniprot.org/uniprotkb/A0A087WPC3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0A087WPC3", "url": "https://www.uniprot.org/uniprotkb/A0A087WPC3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 243, "end_pos": 245, "annotation": "n_glycosylation_sequon" }, { "start_pos": 276, "end_pos": 278, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "structures": [ { "pdb_id": "AF-A0A087WPC3-F1", "pdb_chain": "global", "start_pos": 1, "end_pos": 509, "overlap": "1.0", "method": "AlphaFold", "type": "alphafold", "resolution": -1.0, "url": "https://data.glygen.org/ln2downloads/pdb/current/AF-A0A087WPC3-F1.pdb", "url_external": "https://alphafold.ebi.ac.uk/entry/A0A087WPC3" } ], "synthesized_glycans": [], "enzyme_annotation": [], "cluster_types": [ { "name": "homologset.agr", "label": "AGR Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 243, "end_pos": 245 }, { "start_pos": 276, "end_pos": 278 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }