{ "uniprot_canonical_ac": "A0A096MJS9-1", "uniprot_ac": "A0A096MJS9", "uniprot_id": "A0A096MJS9_RAT", "mass": { "chemical_mass": 67698.0, "monoisotopic_mass": 67698.0 }, "refseq": { "ac": "XP_003751543", "name": "N-acetyltransferase ESCO2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003751543" }, "gene_names": [ { "name": "Esco2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprotkb/A0A096MJS9", "id": "A0A096MJS9" }, { "name": "Esco2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003751543", "id": "XP_003751543" } ], "protein_names": [ { "name": "Establishment of sister chromatid cohesion N-acetyltransferase 2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprotkb/A0A096MJS9/entry#names_and_taxonomy", "id": "A0A096MJS9" }, { "name": "N-acetyltransferase ESCO2", "resource": "RefSeq", "type": "synonym", "url": 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"description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of 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}, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung 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"description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ], "unlinked_id_list": [ "DOID:4765" ], "evidence": [ { "id": "1324", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:1324" } ] }, { "disease_id": "DOID:3910", "recommended_name": { "id": "DOID:3910", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3910", "name": "lung adenocarcinoma", "description": "A lung non-small cell carcinoma that derives_from epithelial cells of glandular origin." }, "synonyms": [ { "id": "DOID:3910", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3910", "name": "bronchogenic lung adenocarcinoma", "description": "" }, { "id": "DOID:3910", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3910", "name": "nonsmall cell adenocarcinoma", "description": "" } ], "unlinked_id_list": [], "evidence": [ { "id": "3910", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:3910" } ] }, { "disease_id": "DOID:5325", "recommended_name": { "id": "DOID:5325", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5325", "name": "Roberts syndrome", "description": "A syndrome characterized by tetraphocomelia, craniofacial anomalies, growth retardation, intellectual disability, and cardiac and renal abnormalities that has_material_basis_in homozygous or compound heterozygous mutation in the ESCO2 gene on chromosome 8p21.1." }, "synonyms": [ { "id": "DOID:5325", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5325", "name": "RBS", "description": "" }, { "id": "DOID:5325", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5325", "name": "LONG BONE DEFICIENCIES ASSOCIATED WITH CLEFT LIP-PALATE", "description": "" }, { "id": "DOID:5325", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5325", "name": "Roberts-Sc Phocomelia Syndrome", "description": "" }, { "id": "DOID:5325", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5325", "name": "SC phocomelia syndrome", "description": "" }, { "id": "MONDO:0100253", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100253", "name": "Roberts-SC phocomelia syndrome", "description": "A rare genetic syndrome with an autosomal recessive pattern of inheritance. It is caused by a mutation in the ESCO2 gene. Clinical signs at birth include multiple limb and facial abnormalities." }, { "id": "MONDO:0100253", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100253", "name": "Appelt-Gerken-Lenz syndrome", "description": "" }, { "id": "MONDO:0100253", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100253", "name": "ESCO2 spectrum disorder", "description": "" }, { "id": "MONDO:0100253", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100253", "name": "RBS", "description": "" }, { "id": "MONDO:0100253", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100253", "name": "Roberts syndrome", "description": "" }, { "id": "MONDO:0100253", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100253", "name": "Roberts syndrome/SC phocomelia", "description": "" }, { "id": "MONDO:0100253", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100253", "name": "Roberts tetraphocomelia syndrome", "description": "" }, { "id": "MONDO:0100253", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100253", "name": "Roberts-SC phocomelia syndrome", "description": "" }, { "id": "MONDO:0100253", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100253", "name": "SC phocomelia syndrome", "description": "" }, { "id": "MONDO:0100253", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100253", "name": "hypomelia hypotrichosis facial hemangioma syndrome", "description": "" }, { "id": "MONDO:0100253", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100253", "name": "long bone deficiencies associated with cleft lip-palate", "description": "" }, { "id": "MONDO:0100253", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100253", "name": "phocomelia-pseudothalidomide syndrome", "description": "" }, { "id": "MONDO:0100253", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100253", "name": "pseudothalidomide syndrome", "description": "" }, { "id": "MONDO:0100253", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100253", "name": "tetraphocomelia-cleft palate syndrome", "description": "" }, { "id": "MONDO:0100253", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100253", "name": "SC phocomelia", "description": "" }, { "id": "MONDO:0100253", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100253", "name": "SC phocomelia syndrome (mild variant of Roberts syndrome)", "description": "" }, { "id": "MONDO:0100253", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100253", "name": "SC pseudothalidomide syndrome", "description": "" }, { "id": "MONDO:0100253", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100253", "name": "Roberts-SC phocomelia syndrome", "description": "A rare genetic syndrome with an autosomal recessive pattern of inheritance. It is caused by a mutation in the ESCO2 gene. Clinical signs at birth include multiple limb and facial abnormalities." }, { "id": "MONDO:0100253", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100253", "name": "Appelt-Gerken-Lenz syndrome", "description": "" }, { "id": "MONDO:0100253", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100253", "name": "ESCO2 spectrum disorder", "description": "" }, { "id": "MONDO:0100253", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100253", "name": "RBS", "description": "" }, { "id": "MONDO:0100253", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100253", "name": "Roberts syndrome", "description": "" }, { "id": "MONDO:0100253", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100253", "name": "Roberts syndrome/SC phocomelia", "description": "" }, { "id": "MONDO:0100253", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100253", "name": "Roberts tetraphocomelia syndrome", "description": "" }, { "id": "MONDO:0100253", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100253", "name": "Roberts-SC phocomelia syndrome", "description": "" }, { "id": "MONDO:0100253", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100253", "name": "SC phocomelia syndrome", "description": "" }, { "id": "MONDO:0100253", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100253", "name": "hypomelia hypotrichosis facial hemangioma syndrome", "description": "" }, { "id": "MONDO:0100253", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100253", "name": "long bone deficiencies associated with cleft lip-palate", "description": "" }, { "id": "MONDO:0100253", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100253", "name": "phocomelia-pseudothalidomide syndrome", "description": "" }, { "id": "MONDO:0100253", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100253", "name": "pseudothalidomide syndrome", "description": "" }, { "id": "MONDO:0100253", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100253", "name": "tetraphocomelia-cleft palate syndrome", "description": "" }, { "id": "MONDO:0100253", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100253", "name": "SC phocomelia", "description": "" }, { "id": "MONDO:0100253", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100253", "name": "SC phocomelia syndrome (mild variant of Roberts syndrome)", "description": "" }, { "id": "MONDO:0100253", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100253", "name": "SC pseudothalidomide syndrome", "description": "" }, { "id": "MIM:268300", "resource": "MIM", "url": "https://www.omim.org/entry/268300", "name": "Roberts-SC phocomelia syndrome", "description": "Roberts-SC phocomelia syndrome" } ], "unlinked_id_list": [], "evidence": [ { "id": "5325", "database": "AGR", "url": "https://www.alliancegenome.org/disease/DOID:5325" } ] }, { "disease_id": "DOID:7148", "recommended_name": { "id": "DOID:7148", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:7148", "name": "rheumatoid arthritis", "description": "An arthritis that is an autoimmune disease which attacks healthy cells and tissue located_in joint." }, "synonyms": [ { "id": "DOID:7148", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:7148", "name": "Arthritis or polyarthritis, rheumatic", "description": "" }, { "id": "DOID:7148", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:7148", "name": "atrophic Arthritis", "description": "" }, { "id": "MONDO:0008383", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008383", "name": "rheumatoid arthritis", "description": "A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. 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"OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45884", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45884", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45884:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45884:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13878", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13878", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13880", "url": "https://www.ebi.ac.uk/interpro/entry/pfam/PF13880", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-2468052", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2468052", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_003751543", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003751543", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1593313", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1593313", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "45948", "url": "https://www.rhea-db.org/rhea/45948", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A096MJS9", "url": "https://www.uniprot.org/uniprotkb/A0A096MJS9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A096MJS9-1", "url": "https://www.uniprot.org/uniprotkb/A0A096MJS9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6ADX3", "url": "https://www.uniprot.org/uniprotkb/A0A8I6ADX3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6ADX3-1", "url": "https://www.uniprot.org/uniprotkb/A0A8I6ADX3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMMATFTPRKRKRHTLKADNDDSLLTDISSSKLRFAENLYSSPNKKHNCQSSVQKEEKPCSHQRHFSSSPLKTTENNMLSFANHSSLFKPVVSTVSFYNKNKHYLNPLERKLIRECKSICLATKNEDKPFPSVTEKIQRKPVCTKNKKRQKSLTANHQPNYKHVKSISRNLKNSKPSQVTYKPVVDKENSCFPPENPPNSPPRVLSQKIRPRVTLQGGAAFFVRKRNFLKKSPLEDKPLPILLQKNEPEVTEDALEAKQVPKSLLVGEKSNVELLDARSESEEKLGKNSSGAVVSSKECKLGKHNFPSEKSLENKTISSESVYSIFSVSSTNTKRSPSEEQSSVGSTACTNFLKQTNVQKNINFRDTNKGGKDQLVIDAGQKHFGTTMCKSCGMIYTASNPEDEIQHLQHHHRFLEGIKYVGWKRERIVAEFWDGKIVLVLPRDPSYAIKKVEDVQELVDLELGFQQVVPMCPNKTKTFLFIDEKRVVGCLIAEPIKQAFRVLSEPSTTKECSRAWRCSDVPEPAICGISRIWVFKLKRRKRIARRLVDTVRNCFMFGCFLSINEIAFSDPTPDGKLFATKYCNTPNFLVYNFHS", "length": 595, "header": "tr|A0A096MJS9-1|A0A096MJS9_RAT Isoform 1 of Establishment of sister chromatid cohesion N-acetyltransferase 2 OS=Rattus norvegicus OX=10116 GN=Esco2 PE=3 SV=1 CANONICAL=A0A096MJS9-1" }, "isoforms": [ { "isoform_ac": "A0A096MJS9-1", "url": "https://www.uniprot.org/uniprotkb/A0A096MJS9/entry#A0A096MJS9-1", "sequence": { "sequence": "MMMATFTPRKRKRHTLKADNDDSLLTDISSSKLRFAENLYSSPNKKHNCQSSVQKEEKPCSHQRHFSSSPLKTTENNMLSFANHSSLFKPVVSTVSFYNKNKHYLNPLERKLIRECKSICLATKNEDKPFPSVTEKIQRKPVCTKNKKRQKSLTANHQPNYKHVKSISRNLKNSKPSQVTYKPVVDKENSCFPPENPPNSPPRVLSQKIRPRVTLQGGAAFFVRKRNFLKKSPLEDKPLPILLQKNEPEVTEDALEAKQVPKSLLVGEKSNVELLDARSESEEKLGKNSSGAVVSSKECKLGKHNFPSEKSLENKTISSESVYSIFSVSSTNTKRSPSEEQSSVGSTACTNFLKQTNVQKNINFRDTNKGGKDQLVIDAGQKHFGTTMCKSCGMIYTASNPEDEIQHLQHHHRFLEGIKYVGWKRERIVAEFWDGKIVLVLPRDPSYAIKKVEDVQELVDLELGFQQVVPMCPNKTKTFLFIDEKRVVGCLIAEPIKQAFRVLSEPSTTKECSRAWRCSDVPEPAICGISRIWVFKLKRRKRIARRLVDTVRNCFMFGCFLSINEIAFSDPTPDGKLFATKYCNTPNFLVYNFHS", "length": 595, "header": "tr|A0A096MJS9-1|A0A096MJS9_RAT Isoform 1 of Establishment of sister chromatid cohesion N-acetyltransferase 2 OS=Rattus norvegicus OX=10116 GN=Esco2 PE=3 SV=1 CANONICAL=A0A096MJS9-1" }, "locus": { "chromosome": "15", "start_pos": 40050819, "end_pos": 40036087, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000076451.3", "url": "https://www.ensembl.org/id/ENSRNOT00000076451.3" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000068247.1", "url": "https://www.ensembl.org/id/ENSRNOP00000068247.1" } ] } }, { "isoform_ac": "A0A8I6ADX3-1", "url": "https://www.uniprot.org/uniprotkb/A0A096MJS9/entry#A0A8I6ADX3-1", "sequence": { "sequence": "MMMATFTPRKRKRHTLKADNDDSLLTDISSSKLRFAENLYSSPNKKHNCQSSVQKEEKPCSHQRHFSSSPLKTTENNMLSFANHSSLFKPVVSTVSFYNKNKHYLNPLERKLIRECKSICLATKNEDRPFPSVTEKIQRKPVCTKNKKRQKSLTANHQPNYKHVKSISRNLKNSKPSQVTYKPVVDKENSCFPTENPPNSPPRVLSQKIRPRVTLQGGAAFFVRKRNFLKKSPLEDKPLPILLQKNEPEVTEDALEAKQVPKSLLVGEKSNVELLDARSESEEKLGKNSSGAVVSSKECKLDKHNFPSEKSLENKTISSESVYSIFSVSSTNTKRSPSEEQSSVGSPACTNFLKQTNVQKNINFRDTNKGGKDQLVIDASQKHFGTTMCKSCGMIYTASNPEDEIQHLQHHHRFLEGIKYVGWKRERIVAEFWDGKIVLVLPRDPSYAIKKVEDVQELVDLELGFQQVVPMCPNKTKTFLFIDEKRVVGCLIAEPIKQAFRVLSEPSTTKECSRAWRCSDVPEPAICGISRIWVFKLKRRKRIARRLVDTVRNCFMFGCFLSINEIAFSDPTPDGKLFATKYCNTPNFLVYNFHS", "length": 595, "header": "tr|A0A8I6ADX3-1|A0A096MJS9_RAT Computationally mapped isoform of Establishment of sister chromatid cohesion N-acetyltransferase 2 OS=Rattus norvegicus OX=10116 GN=Esco2 PE=3 SV=1 CANONICAL=A0A096MJS9-1" }, "locus": { "chromosome": "15", "start_pos": 50455622, "end_pos": 50453838, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000045917.5", "url": "https://www.ensembl.org/id/ENSRNOT00000045917.5" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000090628.1", "url": "https://www.ensembl.org/id/ENSRNOP00000090628.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "rno:691979", "name": "", "url": "https://www.genome.jp/dbget-bin/www_bget?rno:691979", "resource": "KEGG Pathway" }, { "id": "R-RNO-2468052", "name": "", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2468052", "resource": "Reactome", "description": "Establishment of Sister Chromatid Cohesion" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8M2BLF3-1", "protein_name": "N-acetyltransferase ESCO1 isoform X1", "gene_name": "esco1", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MPGQKRKMSSSEPEVKKTKLDRNLVESDKSQKPKRGRPPKSKVLEAQPSRQKHQIDSREENGKPIRRSSRLKTPLKKGARARRRKDGEKPKVSEEKSSQKMPVLKKGNKKYVSRVKREKPIISETIKTVAAMFPVQIEHNYGRLFDMQAEEITLPKPDKIHVANKSEMQALHETQASKAEEQKELHAEPVEKITVSVDAKVDVMSKSPPPLEALFKVIQESSLTKHSFSGKDISDMDELEVVNTCSLQDSVQSTDVAKVFLQDSDAFLDDDVEIENCVVEIETYEDLDGDQGEVSKKQTSECVTCKEVNSSPSLPQESATDSSQELPKKQAMNPQARTKARLAALAEERAAAAKKPPPRHFNLLALCEEIADDIASDAPGASDKTTNEQQQEDHESEDVSECTEVSESKDASESKEVNESKDLSESKDASESKDVSENKEVSETETCEPEEVVSENTAPPGTPNEETADPRPEDGTPKKRFFLSQMSVPLKTQEKKKLSRFQRLRQVELQRDKLTWTRVKKLKSDQVNQAGSQKDSEASSVSPSPATTPAQVPTTESVPKVGSVEPKRVLPAQAPPMPNGITSPKPKPVVEYKPYTPRRKYSPDDFELDGFEEDTAKPAAPKNVGKAEQSPSSAKVQPNPAVERKLCVPTTADSKSKSSPQQETAQQTQLENSNSSSVEPEQKKEDKNSPKPESPAAQSSNEAGQKAFGAVTCNVCGMLYSPTSAEDESQHLLFHNQFISAVRYVGWKKERILGEYPDGKIILVLPDDPKYALKKVEEIREMVDNDLGFQQVESKVPSQTKTFLFISNDKKVAGCLIAEHIQEGYRVIEESVLEGSEGEKVMYERQRAWCCSTVPEPALCGISRIWVFSMMRRRGIASRMIECLRNNFIYGSHLSKDEIAFSDPTPDGKLFATHYCGTSQFLVYNFVSGKRST", "length": 933 }, "evidence": [ { "id": "SGD:S000001923", "url": "https://alliancegenome.org/gene/SGD:S000001923#orthology", "database": "AGR" }, { "id": "FB:FBgn0035766", "url": "https://alliancegenome.org/gene/FB:FBgn0035766#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "A6QNP8-1", "protein_name": "ESCO2 protein", "gene_name": "ESCO2", "tax_id": 9913, "organism": "Bos taurus", "sequence": { "sequence": "MSTLTPTKRKQCSLSQDIPLSDIPSKKLILDFTENVFPLPNKKHICQTSDKNEGKIHCSQQGHLISSPLRTTKNGLPSANKGSPFKSAVSVVSFYNKDKWYLNPLERKLIKESRSIGLKTNNEDKSYSYMTEKMQGKPVCSKKMNKKPQKSLTAKCQVGYKCIKPVSKNSKNSKQYRVTYKPTVENNCYSAENNLNAPRVLSQKVKPQVTFQGGAAFFVSRKKPSLRKSSLEDKLLLGLTQKNKSEVIEESDGETVNERRFETRQAPKCVLVEKELNVELLSERSKSEEKLIKDASDGVISSRECKTDENKSCPSEESFSENKAVSPESIVYPIFTMSSVNTKRSLVEEQSSVGSTTSTNFLKQVNIQKSTNTRDSNKETKDQLIIDAGQKHFGATMCKSCGMIYAASNPEDELQHVQHHHRFVEGIKYTGWKKERVVAEFWDGKIVLVLPRDPSYAIRKVEDVQELVDNELGFQQVVPKYPNKTKTLLFISDEKKVVGCLIAEPIKQAFRVLSEPTGPETPSSKECQRAWQCSDVPEPAVCGISRIWVFRLKRRKRIARRLVDTLRNCFMFGCFLSTNEIAFSDPTPDGKLFATKYCNTPNFLVYNFNN", "length": 610 }, "evidence": [ { "id": "A0A096MJS9", "url": "https://omabrowser.org/oma/group/A0A096MJS9/", "database": "OMA" } ], "glygen_name": "Bovine", "common_name": "Bovine" }, { "uniprot_canonical_ac": "B2GUX2-1", "protein_name": "Esco1 protein", "gene_name": "Esco1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSIQEKSKENSSKVIKESEGENLEQEIEGSQNSLAKKSGSKEAGKSAVRFSNKSKVNQSEIGTRMSTRSASCSADKNATNSINKNMVSVKGQSQESLKKKKLCQEKLSFGTFKGSEQLNRRSQRLQQLTESLTRSLRSREIQGQIQTVKQNLQPARREQCNSTQSKCNKVNQKHVKRKVLEIKSDCKEDRHSVTNEVINSPKGKKRKVQHQTTSTCSSQCIQGSEKCLQKTIRKEETKPVPVTAEIRKLKTATSVVSKRNELRKSAHTQVSASTKFPQIPLPLVPEHSVDHELEQPGKSKRGSILQLCEEIAGEIESDTVEVKKESCVESVKEEKPAEVKLEETDAERQTLHQKETNQDVQCNRFFPSRKTKPVKCVLNGINSSTKKNSNWTKIKLSKFNSVHQHKLDSQVSPKLSLLQTFLSPPVLEMPHPVSQSTFLEMKPHGTVTCQQDKMKGIKSEDVKINNIAIEINKATKRAPGNCNLDNHIKPSSDSSLDNQMKHSCESAPDQNFSICSASEVETNPLENTAAVSTLLSQARIDGDRKFPGSAPNQQHSILSNEASINRKNRDTPPNHSQLKCNSNLEITIPKSLKLKDSEKVDEKQLVIDAGHKRFGAVSCNICGMLYTASNPEDETQHLLFHNQFISAVKYVGWKKERILAEYPDGRIIMVLPEDPKYALKKVDEIREMVDNDLGFQQAPLMCYSRTKTLLFISNDKKVVGCLIAEHIQWGYRVIEEKLPVIRSEEEKVRFERQKAWCCSTLPEPAICGISRIWVFSMMRRKKIASRMIECLRSNFIYGSYLSKEEIAFSDPTPDGKLFATQYCGTGQFLVYNFINGQNTT", "length": 840 }, "evidence": [ { "id": "SGD:S000001923", "url": "https://alliancegenome.org/gene/SGD:S000001923#orthology", "database": "AGR" }, { "id": "FB:FBgn0035766", "url": "https://alliancegenome.org/gene/FB:FBgn0035766#orthology", "database": "AGR" } ], "glygen_name": "Rat", "common_name": "Rat" }, { "uniprot_canonical_ac": "P43605-1", "protein_name": "N-acetyltransferase ECO1", "gene_name": "ECO1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MKARKSQRKAGSKPNLIQSKLQVNNGSKSNKIVKCDKCEMSYSSTSIEDRAIHEKYHTLQLHGRKWSPNWGSIVYTERNHSRTVHLSRSTGTITPLNSSPLKKSSPSITHQEEKIVYVRPDKSNGEVRAMTEIMTLVNNELNAPHDENVIWNSTTEEKGKAFVYIRNDRAVGIIIIENLYGGNGKTSSRGRWMVYDSRRLVQNVYPDFKIGISRIWVCRTARKLGIATKLIDVARENIVYGEVIPRYQVAWSQPTDSGGKLASKYNGIMHKSGKLLLPVYI", "length": 281 }, "evidence": [ { "id": "RGD:1593313", "url": "https://alliancegenome.org/gene/RGD:1593313#orthology", "database": "AGR" }, { "id": "HGNC:27230", "url": "https://alliancegenome.org/gene/HGNC:27230#orthology", "database": "AGR" }, { "id": "MGI:1919238", "url": "https://alliancegenome.org/gene/MGI:1919238#orthology", "database": "AGR" }, { "id": "SGD:S000001923", "url": "https://alliancegenome.org/gene/SGD:S000001923#orthology", "database": "AGR" }, { "id": "FB:FBgn0035766", "url": "https://alliancegenome.org/gene/FB:FBgn0035766#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-050913-156", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-050913-156#orthology", "database": "AGR" } ], "glygen_name": "Yeast", "common_name": "Baker's yeast" }, { "uniprot_canonical_ac": "Q56NI9-1", "protein_name": "N-acetyltransferase ESCO2", "gene_name": "ESCO2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAALTPRKRKQDSLKCDSLLHFTENLFPSPNKKHCFYQNSDKNEENLHCSQQEHFVLSALKTTEINRLPSANQGSPFKSALSTVSFYNQNKWYLNPLERKLIKESRSTCLKTNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKYRHIKPVSRNSRNSKQNRVIYKPIVEKENNCHSAENNSNAPRVLSQKIKPQVTLQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEVIEDSDVETVSEKKTFATRQVPKCLVLEEKLKIGLLSASSKNKEKLIKDSSDDRVSSKEHKVDKNEAFSSEDSLGENKTISPKSTVYPIFSASSVNSKRSLGEEQFSVGSVNFMKQTNIQKNTNTRDTSKKTKDQLIIDAGQKHFGATVCKSCGMIYTASNPEDEMQHVQHHHRFLEGIKYVGWKKERVVAEFWDGKIVLVLPHDPSFAIKKVEDVQELVDNELGFQQVVPKCPNKIKTFLFISDEKRVVGCLIAEPIKQAFRVLSEPIGPESPSSTECPRAWQCSDVPEPAVCGISRIWVFRLKRRKRIARRLVDTLRNCFMFGCFLSTDEIAFSDPTPDGKLFATKYCNTPNFLVYNFNS", "length": 601 }, "evidence": [ { "id": "RGD:1593313", "url": "https://alliancegenome.org/gene/RGD:1593313#orthology", "database": "AGR" }, { "id": "HGNC:27230", "url": "https://alliancegenome.org/gene/HGNC:27230#orthology", "database": "AGR" }, { "id": "MGI:1919238", "url": "https://alliancegenome.org/gene/MGI:1919238#orthology", "database": "AGR" }, { "id": "SGD:S000001923", "url": "https://alliancegenome.org/gene/SGD:S000001923#orthology", "database": "AGR" }, { "id": "FB:FBgn0035766", "url": "https://alliancegenome.org/gene/FB:FBgn0035766#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-050913-156", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-050913-156#orthology", "database": "AGR" }, { "id": "A0A096MJS9", "url": "https://omabrowser.org/oma/group/A0A096MJS9/", "database": "OMA" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5FWF5-1", "protein_name": "N-acetyltransferase ESCO1", "gene_name": "ESCO1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MMSIQEKSKENSSKVTKKSDDKNSETEIQDSQKNLAKKSGPKETIKSQAKSSSESKINQPELETRMSTRSSKAASNDKATKSINKNTVTVRGYSQESTKKKLSQKKLVHENPKANEQLNRRSQRLQQLTEVSRRSLRSREIQGQVQAVKQSLPPTKKEQCSSTQSKSNKTSQKHVKRKVLEVKSDSKEDENLVINEVINSPKGKKRKVEHQTACACSSQCTQGSEKCPQKTTRRDETKPVPVTSEVKRSKMATSVVPKKNEMKKSVHTQVNTNTTLPKSPQPSVPEQSDNELEQAGKSKRGSILQLCEEIAGEIESDNVEVKKESSQMESVKEEKPTEIKLEETSVERQILHQKETNQDVQCNRFFPSRKTKPVKCILNGINSSAKKNSNWTKIKLSKFNSVQHNKLDSQVSPKLGLLRTSFSPPALEMHHPVTQSTFLGTKLHDRNITCQQEKMKEINSEEVKINDITVEINKTTERAPENCHLANEIKPSDPPLDNQMKHSFDSASNKNFSQCLESKLENSPVENVTAASTLLSQAKIDTGENKFPGSAPQQHSILSNQTSKSSDNRETPRNHSLPKCNSHLEITIPKDLKLKEAEKTDEKQLIIDAGQKRFGAVSCNVCGMLYTASNPEDETQHLLFHNQFISAVKYVGWKKERILAEYPDGRIIMVLPEDPKYALKKVDEIREMVDNDLGFQQAPLMCYSRTKTLLFISNDKKVVGCLIAEHIQWGYRVIEEKLPVIRSEEEKVRFERQKAWCCSTLPEPAICGISRIWVFSMMRRKKIASRMIECLRSNFIYGSYLSKEEIAFSDPTPDGKLFATQYCGTGQFLVYNFINGQNST", "length": 840 }, "evidence": [ { "id": "SGD:S000001923", "url": "https://alliancegenome.org/gene/SGD:S000001923#orthology", "database": "AGR" }, { "id": "FB:FBgn0035766", "url": "https://alliancegenome.org/gene/FB:FBgn0035766#orthology", "database": "AGR" } ], "glygen_name": "Human", "common_name": "Human" }, { "uniprot_canonical_ac": "Q5SPR8-1", "protein_name": "N-acetyltransferase ESCO2", "gene_name": "esco2", "tax_id": 7955, "organism": "Danio rerio", "sequence": { "sequence": "MLSRKRKHGSPDAESNPSKKQITSLRSSPRRTTRQKENIPISLNSPQKIPSTPKKTQRAFLLESPPKRVSPRKAVLGAGTFYSKQKPLYLTPLERKVLKEAKSPPSVTNKEPSRPPLTAANQVVKPAKKVQKKPRASAPQSNLKGYFTAKPKATKSSSDKQTDQVLKSTMAPISFSSMKSKGKPKLVVGAAFFNTGKKPTSMYKKSAQNTKPKPTYEKPSIRKPVREKELVTAPGQRSPVRRAVFLKKQPEVEVSHDKRESTQAPMSPQVLADVHGITKELRVVLRRSVSPETGSQDAPSEADSVFDVSDLLLPDHDSSHDEEESSVYPIFGTKRPQKKGKLSPPLNSSTPSALTATPALKAKERSMLRREMKKQTDNQLIIDAGQKQFGATTCASCGMLYSTDSPEDNFQHTQFHQRFLDTIKFVGWKKERVVAEFWDGKIILVLPDDPKYATRKAEDVRRIADSELGFQQITLSSPSSAKTYLFINTDRMVVGCLVAENIRQAYRVLEQQEKQKDMSKEDFMEHHRTWCCSTVPEKALCGVSRIWVFSLMRRKSVATRLLDTARNTFMYGSHLTKEEIAFSDPTPQGKLFATKYCQTPTFLVYNFIS", "length": 609 }, "evidence": [ { "id": "RGD:1593313", "url": "https://alliancegenome.org/gene/RGD:1593313#orthology", "database": "AGR" }, { "id": "HGNC:27230", "url": "https://alliancegenome.org/gene/HGNC:27230#orthology", "database": "AGR" }, { "id": "MGI:1919238", "url": "https://alliancegenome.org/gene/MGI:1919238#orthology", "database": "AGR" }, { "id": "SGD:S000001923", "url": "https://alliancegenome.org/gene/SGD:S000001923#orthology", "database": "AGR" }, { "id": "FB:FBgn0035766", "url": "https://alliancegenome.org/gene/FB:FBgn0035766#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-050913-156", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-050913-156#orthology", "database": "AGR" } ], "glygen_name": "Zebrafish", "common_name": "Zebrafish" }, { "uniprot_canonical_ac": "Q69Z69-1", "protein_name": "N-acetyltransferase ESCO1", "gene_name": "Esco1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSIQEKSKENSSIVTKESEDENLEEEVESSQNSPTKKSGSKEAVKTPVRFSNKSKTNESEFGMRMSTRSASCSADKTATNSFNKNTVTLKGQSQESSKTKKLCQEKLSLGILKGNEQLHRRSQRLQQLTECTTRSLRSREIHGQIQTVKQNQQSARREQCNSTQSKCNKVKVNQKHVKRKVLEIKSDCKEDRHSVTNEVINSPKGKKRKVQHQTTSTCSSQCNQGSEKCLQKTSRKEEIKPVPVTADIRKLKAATSVVSKKNELRKSAHTQVSTSTKRPQIPLPLVPEHSDDQELEQAGKSKRGSILQLCEEIAGEIESDTVEVKKESSCVESVKEEKPAEVKLQGTDAERQILHHKEANQDVRSNRFFPSRKTKPVKCVLNGINSSTKKNSNWTKIKLSKFNSVQQHKLDSQVSPKLNLLQTGLSTSVLEMPHPVSQSTFLEMKAHGNVTCQRDKMKGIKSEEVKINNIAIEINKATKRDPGNCNLDNHIKPSPDSSLDNQMKLSCESAPDQNFSICSASEVETNPLENTAAASTLLSQAKIDEDRTFPGSAPNQQHSVLSDEASINRKNRDVPPNHSQLKHDSHLEITIPKSLKLKDSEKVDEKQLVIDAGHKRFGAVSCNICGMLYTASNPEDETQHLLFHNQFISAVKYVGWKKERILAEYPDGRIIMVLPEDPKYALKKVDEIREMVDNDLGFQQAPLMCYSRTKTLLFISNDKKVVGCLIAEHIQWGYRVIEEKLPVIRSEEEKVRFERQKAWCCSTLPEPAICGISRIWVFSMMRRKKIASRMIECLRSNFIYGSYLSKEEIAFSDPTPDGKLFATQYCGTGQFLVYNFINGQNTT", "length": 843 }, "evidence": [ { "id": "SGD:S000001923", "url": "https://alliancegenome.org/gene/SGD:S000001923#orthology", "database": "AGR" }, { "id": "FB:FBgn0035766", "url": "https://alliancegenome.org/gene/FB:FBgn0035766#orthology", "database": "AGR" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8CIB9-1", "protein_name": "N-acetyltransferase ESCO2", "gene_name": "Esco2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MMATCTPRKRKRYTLNADNDDSLLTDISSSKLRCAENLFPSPNKKHNYQSSVQKEDKSCSHQLHFPSSPLKTTENSRFSFANHSSLFKPAMSTVSFYSKEKYYLNPLERKLIRECRSICLATESGDKPIPSVTENIQRKPVCTKKNKKKQKSLTAKYQPNYKHIKSKSRNLKNSKPNQVTYKPVVDQENSCFPAKNYPNSPPRVLSQKIKPQVTLQGGAAFFVRKRNSLKKLPLEDKPLLLQKNLPEVPEGAPEAKQIPKSLLVDEKSSVKVQNARSKNEEKLRKNPSGAVVSSKECNLDKHDFPSENSLDENKTISPESVYPIFNVSSVNTKRPEEQSSVGSTACTNFLKQTNVPKNINSRDTNKGGKDQLVIDAGQKHFGTTVCKSCGMIYTASNPEDEIQHLQHHHRFLEGIKFVGWKRERVVAEFWDGKIVLVLPRDPSYAIKKVEDVQELVDLELGFQQTVPVCPDKTKTFLFIDEKRVVGCLIAEPIKQAFRVLSEPSASKECSRAWRCSDVPEPAICGISRIWVFRLKRRKRIARRLVDTVRNCFMFGCFLSTNEIAFSDPTPDGKLFATKYCNTPNFLVYNFHN", "length": 592 }, "evidence": [ { "id": "RGD:1593313", "url": "https://alliancegenome.org/gene/RGD:1593313#orthology", "database": "AGR" }, { "id": "HGNC:27230", "url": "https://alliancegenome.org/gene/HGNC:27230#orthology", "database": "AGR" }, { "id": "MGI:1919238", "url": "https://alliancegenome.org/gene/MGI:1919238#orthology", "database": "AGR" }, { "id": "SGD:S000001923", "url": "https://alliancegenome.org/gene/SGD:S000001923#orthology", "database": "AGR" }, { "id": "FB:FBgn0035766", "url": "https://alliancegenome.org/gene/FB:FBgn0035766#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-050913-156", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-050913-156#orthology", "database": "AGR" }, { "id": "A0A096MJS9", "url": "https://omabrowser.org/oma/group/A0A096MJS9/", "database": "OMA" } ], "glygen_name": "Mouse", "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VS50-1", "protein_name": "N-acetyltransferase eco", "gene_name": "eco", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "METPTGSGRPSRMATPRLSERKRQLFGSPRSRLRQINDDEDDADVDSLGVLPLKTHVAANRKGRSLFAAVPGKSSSSANSSPETNKENKKTRGGVMTATAEQLPQLFTATMRLNSNSSSNSRNSSPRQTRVQRKRADSSMSSPTSSSEGTPSSRARNSIRRSPRTFSAQKDPDAFSSPESFQTRLSKVAAMLMKGQDSRSMLEKSKKKHNHSLKTTAQVHTTKPKKTSPAEESQSDDEKPSSSKNSRKNTEVRETRSSQIISPKTRNRRRPFTSADINCKTLKAAAHLHENMRSYDEEKTAAVKLENSRSRSKSPVEVFKSNDDAVKRNTGNTNNKTAKSSEVATAKRPESPGSSMKIDVEVPESDEEASNHKPQKRQHPETSTPVAPSADADSGSPQSKMRKVTLSSSIPTMAFYSHSGEAVTKSRRRPSISKNSLKQPTKISPTSRPLLGINKGVHHKIRKRHGFANRLPATDMDNILNSLSNERLKNLITTKREERAKVEEVHQILRNAKDPIKMAKPLSVIEADDANNNNNLPATAWQETSADFSDLSDVEDIDPIIEVEPIIPIIRHEPVQKSPTAEPADLSKRKFFKSGRRSSTCMEVRITDNIRASVSQGKIELVQTIRRKPRQVRVKSATIFSAEQATVDAILKNLDDTVVDEIVEANPVVQATPIDAEETTMETESLPDIIEYAPEANDVEIDPFAEFRQRLPYQTDDPNVVEQQQILLEFLISNNICTEKNFEIFIANPDDYKDEANQIVDNLYMVVNSEEAAQLAQMETVENTAVAIAPKQDAPAVEEVQPKLFPIFTQRLQPVVQKSLRRRPDTSMRLLTAAGGSNQYQIDAGQKAFGARQCQQCGLVYTVHEPEEELLHREYHNSIHVLRFKGWIDEDIVSVYPEWASDGRIIRINERAPTARLDRLRDLIGVVDKELGYSSYIVPKIFVAFIAVRKQQIVGFCLVQPLSQAHRFIQVDGTDYFSEESYPASCGVSRIWVSPLQRRSGIASKLLRVVQCHTVLGQEIARECIAFSTPTDDGRALARQFTGLDNFLTYDQ", "length": 1052 }, "evidence": [ { "id": "RGD:1593313", "url": "https://alliancegenome.org/gene/RGD:1593313#orthology", "database": "AGR" }, { "id": "HGNC:27230", "url": "https://alliancegenome.org/gene/HGNC:27230#orthology", "database": "AGR" }, { "id": "MGI:1919238", "url": "https://alliancegenome.org/gene/MGI:1919238#orthology", "database": "AGR" }, { "id": "SGD:S000001923", "url": "https://alliancegenome.org/gene/SGD:S000001923#orthology", "database": "AGR" }, { "id": "FB:FBgn0035766", "url": "https://alliancegenome.org/gene/FB:FBgn0035766#orthology", "database": "AGR" }, { "id": "ZFIN:ZDB-GENE-050913-156", "url": "https://alliancegenome.org/gene/ZFIN:ZDB-GENE-050913-156#orthology", "database": "AGR" } ], "glygen_name": "Fruit fly", "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "protein-lysine-acetyltransferase activity", "id": "GO:0061733", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061733", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJS9", "url": "https://www.uniprot.org/uniprotkb/A0A096MJS9" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJS9", "url": "https://www.uniprot.org/uniprotkb/A0A096MJS9" } ], "pmid": "" }, { "name": "acetyltransferase activity", "id": "GO:0016407", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016407", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJS9", "url": "https://www.uniprot.org/uniprotkb/A0A096MJS9" } ], "pmid": "" }, { "name": "L-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor", "id": "GO:0004468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004468", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJS9", "url": "https://www.uniprot.org/uniprotkb/A0A096MJS9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJS9", "url": "https://www.uniprot.org/uniprotkb/A0A096MJS9" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJS9", "url": "https://www.uniprot.org/uniprotkb/A0A096MJS9" } ], "pmid": "" }, { "name": "site of double-strand break", "id": "GO:0035861", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035861", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJS9", "url": "https://www.uniprot.org/uniprotkb/A0A096MJS9" } ], "pmid": "" }, { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJS9", "url": "https://www.uniprot.org/uniprotkb/A0A096MJS9" } ], "pmid": "" }, { "name": "pericentric heterochromatin", "id": "GO:0005721", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005721", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJS9", "url": "https://www.uniprot.org/uniprotkb/A0A096MJS9" } ], "pmid": "" }, { "name": "chromocenter", "id": "GO:0010369", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010369", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJS9", "url": "https://www.uniprot.org/uniprotkb/A0A096MJS9" } ], "pmid": "" }, { "name": "XY body", "id": "GO:0001741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001741", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJS9", "url": "https://www.uniprot.org/uniprotkb/A0A096MJS9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "chromosome segregation", "id": "GO:0007059", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007059", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJS9", "url": "https://www.uniprot.org/uniprotkb/A0A096MJS9" } ], "pmid": "" }, { "name": "double-strand break repair", "id": "GO:0006302", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006302", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJS9", "url": "https://www.uniprot.org/uniprotkb/A0A096MJS9" } ], "pmid": "" }, { "name": "regulation of DNA replication", "id": "GO:0006275", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006275", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJS9", "url": "https://www.uniprot.org/uniprotkb/A0A096MJS9" } ], "pmid": "" }, { "name": "hematopoietic progenitor cell differentiation", "id": "GO:0002244", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002244", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJS9", "url": "https://www.uniprot.org/uniprotkb/A0A096MJS9" } ], "pmid": "" }, { "name": "mitotic sister chromatid cohesion", "id": "GO:0007064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007064", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJS9", "url": "https://www.uniprot.org/uniprotkb/A0A096MJS9" } ], "pmid": "" }, { "name": "protein localization to chromatin", "id": "GO:0071168", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071168", "evidence": [ { "database": "UniProtKB", "id": "A0A096MJS9", "url": "https://www.uniprot.org/uniprotkb/A0A096MJS9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 288, "end_pos": 290, "annotation": "n_glycosylation_sequon" }, { "start_pos": 314, "end_pos": 316, "annotation": "n_glycosylation_sequon" }, { "start_pos": 474, "end_pos": 476, "annotation": "n_glycosylation_sequon" }, { "start_pos": 83, "end_pos": 85, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "45948", "name": "", "equation": "L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6JHU9-1", "Q9WVS9-1", "Q9EPU2-1", "Q9QXS4-1", "Q3MHC1-1", "Q5M939-1", "Q5TKR9-1", "P62916-1", "D4ACX5-1", "A0A8I6GLZ3-1", "Q810T5-1", "Q00972-1", "A0A8I5Y222-1", "Q6DGG1-1", "Q99MK2-1", "Q5XI06-1", "Q9JIY6-1", "Q9QXT3-1", "D3ZKU7-1" ], "evidence": [ { "id": "45948", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/45948" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A8I5Y222", "gene_name": "Kat2b", "activity": [ { "ec_number": "2.3.1.48", "activity": "L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+).", "evidence": [ { "id": "A0A8I5Y222", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8I5Y222" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "A0A8I5Y222", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8I5Y222" } ] } ] }, { "uniprot_ac": "A0A8I6GLZ3", "gene_name": "Kat6b", "activity": [ { "ec_number": "2.3.1.48", "activity": "L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+).", "evidence": [ { "id": "A0A8I6GLZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLZ3" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "A0A8I6GLZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/A0A8I6GLZ3" } ] } ] }, { "uniprot_ac": "D3ZKU7", "gene_name": "Bloc1s1", "activity": [ { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "D3ZKU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D3ZKU7" } ] } ] }, { "uniprot_ac": "D4ACX5", "gene_name": "Kat2a", "activity": [ { "ec_number": "2.3.1.48", "activity": "L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+).", "evidence": [ { "id": "D4ACX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4ACX5" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "D4ACX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/D4ACX5" } ] } ] }, { "uniprot_ac": "P62916", "gene_name": "Gtf2b", "activity": [ { "ec_number": "2.3.1.48", "activity": "L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+).", "evidence": [ { "id": "P62916", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62916" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "P62916", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/P62916" } ] } ] }, { "uniprot_ac": "Q00972", "gene_name": "Bckdk", "activity": [ { "ec_number": "2.7.11.1", "activity": "L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).", "evidence": [ { "id": "Q00972", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q00972" } ] }, { "ec_number": "2.7.11.4", "activity": "L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ATP = O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ADP + H(+).", "evidence": [ { "id": "Q00972", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q00972" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q00972", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q00972" } ] }, { "ec_number": "2.3.1.48", "activity": "L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+).", "evidence": [ { "id": "Q00972", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q00972" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q00972", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q00972" } ] } ] }, { "uniprot_ac": "Q3MHC1", "gene_name": "Naa60", "activity": [ { "ec_number": "2.3.1.48", "activity": "L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+).", "evidence": [ { "id": "Q3MHC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHC1" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q3MHC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHC1" } ] }, { "ec_number": "2.3.1.259", "activity": "N-terminal L-methionyl-[transmembrane protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein] + CoA + H(+).", "evidence": [ { "id": "Q3MHC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHC1" } ] }, { "ec_number": "2.3.1.259", "activity": "", "evidence": [ { "id": "Q3MHC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q3MHC1" } ] } ] }, { "uniprot_ac": "Q5M939", "gene_name": "Hat1", "activity": [ { "ec_number": "2.3.1.48", "activity": "L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+).", "evidence": [ { "id": "Q5M939", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5M939" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q5M939", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q5M939" } ] } 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