Predicted chicken CFI shows 51% amino acid sequence identity with its human counterpart. The chicken events of complement factor I activity have not been verified experimentally but are inferred from the orthologous human events." ], [ "R-GGA-2132260", "Complement factor I inactivates surface-bound C3b", "extracellular region, plasma membrane", "6214588", "R-GGA-2132281", "", "Complement factor I (CFI) is a serine protease that inhibits all complement pathways by degrading surface-bound C3b and C4b into inactive fragments. Factor I binds to CFH:C3b complex and cleaves C3b, producing iC3b which remains bound to the membrane. iC3b is proteolytically inactive and cannot contribute to the complement cascade process, though it does contribute to opsonization [Ross JD et al 1982; Masaki T et al 1992; Fukui A et al 2002; Nilsson SC et al 2010].
Predicted chicken CFI shows 51% amino acid sequence identity with its human counterpart. The chicken events of complement factor I activity have not been verified experimentally but are inferred from the orthologous human events." ] ] }, "readme": "Name\n - Chicken Protein Reactions (Reactome)\n\nVersion\n - v-2.10.1\n\nCreated on\n - 2019-11-30T15:08:38.029791\n\nModified on\n - 2024-05-21T13:48:30.931Z\n\nCreated by\n - Jeet Vora [jeetvora@gwu.edu], Robel Kahsay [rykahsay@gwu.edu], Karina Martinez [karinamartinez@gwu.edu], Luke Johnson [luke.johnson@email.gwu.edu], Urnisha Bhuiyan [sbhuiyan28@email.gwu.edu], Cyrus Au-Yeung [cyruschauyeung@gwu.edu], Jingyue Wu [jingyue.wu@email.gwu.edu], Kate Warner [k.warner1@gwu.edu]\n\nAuthors\n - Maria Martin [martin@ebi.ac.uk], Preethi Vasudev [pvasudev@ebi.ac.uk]\n\nChecksum\n - \n\nUsability Domain\n - The Chicken Protein Reactions (Reactome) dataset contains reactions information for pathways for Gallus gallus [taxid:9031] UniProtKB accessions that includes reaction participants, pathway ID, reaction ID, PMID etc from Reactome database. If you use this dataset please provide proper attribution to EMBL-EBI-UniProtKB and GlyGen.\n\nDescription Domain\n Keywords\n - Reactome\n - Pathway\n - Reactions\n - PMID\n\n Pipeline Steps\n - Step-1: The script loads the Reactome reaction data from the triplestore containing triples from nt file to retrieve the information associated with the Reactome IDs and maps it to the UniProtKB canonical accessions and extracts the dataset in the csv format\n\nExecution Domain\n Scripts - https://github.com/glygener/glygen-backend-integration/blob/master/dataset-maker/make-protein-dataset.py\n\n\n Software Prerequisites\n Name: Python\n Version: 2.7.5\n URI: https://www.python.org/download/releases/2.7.5/\n\nI/O Domain\n Input Subdomain\n Name: all_blacklisted_pmids.csv\n URI: https:/data.glygen.org/ln2releases/data/v-2.10.1/compiled/all_blacklisted_pmids.csv\n Name: uniprot-proteome-gallus-gallus.nt\n URI: https:/data.glygen.org/ln2downloads/ebi/2025_10_01/uniprot-proteome-gallus-gallus.nt\n Output Subdomain\n Name: chicken_protein_reactions_reactome.csv\n URI: https:/data.glygen.org/ln2releases/data/v-2.10.1/reviewed/chicken_protein_reactions_reactome.csv\n Name: chicken_protein_reactions_reactome.stat.csv\n URI: https:/data.glygen.org/ln2releases/data/v-2.10.1/reviewed/chicken_protein_reactions_reactome.stat.csv\n\nFields\n Name: \"reaction_id\"\n Description: \"The identifier assigned to a reaction in Reactome database\"\n Unique Values: \"5221\"\n Name: \"reaction_name\"\n Description: \"The name assigned to a reaction in Reactome database\"\n Unique Values: \"5196\"\n Name: \"cellular_location\"\n Description: \"The loaction in the cell where reaction occurs\"\n Unique Values: \"200\"\n Name: \"pmid\"\n Description: \"NCBI PubMed database Identifier\"\n Unique Values: \"366\"\n Name: \"pathway_id\"\n Description: \"Pathway Identifier\"\n Unique Values: \"1223\"\n Name: \"equation\"\n Description: \"\"\n Unique Values: \"1\"\n Name: \"reaction_summary\"\n Description: \"\"\n Unique Values: \"243\"", "downloadurl": "/ln2data/releases/data/v-2.10.1/reviewed/chicken_protein_reactions_reactome.csv" }