{
    "bcoid": "GLY_000422",
    "title": "SARS-CoV2 Protein Function (UniProtKB)",
    "description": "The SARS coronavirus (SARS-CoV-2 or 2019-nCov) Protein Function (UniProtKB) dataset contains biological ...",
    "filename_list": "sarscov2_protein_function_uniprotkb.csv",
    "filename": "sarscov2_protein_function_uniprotkb.csv",
    "filetype": "csv",
    "categories": {
        "species": [
            "Severe acute respiratory syndrome coronavirus 2"
        ],
        "molecule": [
            "Protein"
        ],
        "tag": [
            "Protein Function"
        ],
        "file_type": [
            "csv"
        ],
        "status": [
            "Reviewed"
        ],
        "scope": [
            "internal"
        ]
    },
    "minitable": {
        "content": [
            [
                "P0DTC7-1...",
                "protein_xref..."
            ],
            [
                "P0DTC7-1...",
                "protein_xref..."
            ]
        ],
        "headers": [
            "uniprotkb_ca...",
            "xref_key..."
        ],
        "colwidth": [
            "40%",
            "20%"
        ]
    },
    "sampledata": {
        "type": "table",
        "data": [
            [
                {
                    "type": "string",
                    "label": "uniprotkb_canonical_ac"
                },
                {
                    "type": "string",
                    "label": "xref_key"
                },
                {
                    "type": "string",
                    "label": "xref_id"
                },
                {
                    "type": "string",
                    "label": "annotation"
                }
            ],
            [
                "P0DTC7-1",
                "protein_xref_uniprotkb_fun",
                "P0DTC7",
                "Plays a role as antagonist of host tetherin (BST2), disrupting its antiviral effect (PubMed:33930332). Acts by binding to BST2 and sequestering it to perinuclear region, thereby preventing its antiviral function at cell membrane (PubMed:33930332). May specifically downregulate MHC-I allele HLA-A*02:01 (HLA-A2) (PubMed:36574644)."
            ],
            [
                "P0DTC7-1",
                "protein_xref_pubmed",
                "36574644",
                "Plays a role as antagonist of host tetherin (BST2), disrupting its antiviral effect (PubMed:33930332). Acts by binding to BST2 and sequestering it to perinuclear region, thereby preventing its antiviral function at cell membrane (PubMed:33930332). May specifically downregulate MHC-I allele HLA-A*02:01 (HLA-A2) (PubMed:36574644)."
            ]
        ]
    },
    "readme": "Name\n   - SARS-CoV2 Protein Function (UniProtKB)\n\nVersion\n   - v-2.10.1\n\nCreated on\n  - 2020-04-03T11:46:41.584409\n\nModified on\n   - 2024-06-03T21:12:10.065Z\n\nCreated by\n   - Jeet Vora [jeetvora@gwu.edu], Robel Kahsay [rykahsay@gwu.edu], Karina Martinez [karinamartinez@gwu.edu], Luke Johnson [luke.johnson@email.gwu.edu], Urnisha Bhuiyan [sbhuiyan28@email.gwu.edu], Cyrus Au-Yeung [cyruschauyeung@gwu.edu], Kate Warner [k.warner1@gwu.edu]\n\nAuthors\n   - Maria Martin [martin@ebi.ac.uk], Preethi Vasudev [pvasudev@ebi.ac.uk]\n\nChecksum\n   - \n\nUsability Domain\n   - The SARS coronavirus (SARS-CoV-2 or 2019-nCov) Protein Function (UniProtKB) dataset contains biological function annotation for Severe acute respiratory syndrome coronavirus 2 [taxid:2697049] protein accesions from the UniProtKB database. If you use this dataset please provide proper attribution to EMBL-EBI-UniProtKB and GlyGen.\n\nDescription Domain\n   Keywords\n   - protein function\n   - UniProtKB\n\n   Pipeline Steps\n   - Step-1: The script loads the UniProtKB function annotations triplestore containing triples from nt file and extracts the data as a csv dataset\n\nExecution Domain\n   Scripts   - https://github.com/glygener/glygen-backend-integration/blob/master/dataset-maker/make-protein-dataset.py\n\n\n   Software Prerequisites\n      Name: Python\n      Version: 2.7.5\n      URI: https://www.python.org/download/releases/2.7.5/\n\nI/O Domain\n   Input Subdomain\n      Name: all_blacklisted_pmids.csv\n      URI: https:/data.glygen.org/ln2releases/data/v-2.10.1/compiled/all_blacklisted_pmids.csv\n      Name: uniprot-proteome-sars-cov-2.nt\n      URI: https:/data.glygen.org/ln2downloads/ebi/2025_10_01/uniprot-proteome-sars-cov-2.nt\n   Output Subdomain\n      Name: sarscov2_protein_function_uniprotkb.csv\n      URI: https:/data.glygen.org/ln2releases/data/v-2.10.1/reviewed/sarscov2_protein_function_uniprotkb.csv\n      Name: sarscov2_protein_function_uniprotkb.stat.csv\n      URI: https:/data.glygen.org/ln2releases/data/v-2.10.1/reviewed/sarscov2_protein_function_uniprotkb.stat.csv\n\nFields\n      Name: \"uniprotkb_canonical_ac\"\n     Description: \"\"\n      Unique Values: \"14\"\n      Name: \"xref_key\"\n     Description: \"Source key associated to the  xref_id\"\n      Unique Values: \"3\"\n      Name: \"xref_id\"\n     Description: \"ID of the X-ref\"\n      Unique Values: \"93\"\n      Name: \"annotation\"\n     Description: \"Function annotation from UniProtKB|RefSeq database\"\n      Unique Values: \"35\"",
    "downloadurl": "/ln2data/releases/data/v-2.10.1/reviewed/sarscov2_protein_function_uniprotkb.csv"
}