{ "bcoid": "GLY_000638", "title": "Fruitfly Protein Enzyme Annotation (UniProtKB)", "description": "The Fruitfly Protein Enzyme Annotation (UniProtKB) dataset contains fruitfly [taxid:7227] enzyme annotations ...", "filename": "fruitfly_protein_enzyme_annotation_uniprotkb.csv", "filetype": "csv", "categories": { "species": [ "Drosophila melanogaster" ], "molecule": [ "Protein" ], "tags": [ "enzyme annotation" ], "file_type": [ "csv" ], "status": [ "Reviewed" ], "scope": [ "internal" ] }, "minitable": { "content": [ [ "Q8T4G5-1...", "3.4.24.-..." ], [ "Q9V6L0-1...", "1.14.11.27..." ] ], "headers": [ "uniprotkb_ca...", "enzyme_ec..." ], "colwidth": [ "40%", "20%" ] }, "sampledata": { "type": "table", "data": [ [ { "type": "string", "label": "uniprotkb_canonical_ac" }, { "type": "string", "label": "enzyme_ec" }, { "type": "string", "label": "enzyme_activity" } ], [ "Q8T4G5-1", "3.4.24.-", "" ], [ "Q9V6L0-1", "1.14.11.27", "2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + L-lysyl(36)-[histone H3] + 2 succinate." ], [ "Q9VYQ5-1", "1.14.-.-", "" ], [ "Q9VFJ0-1", "1.14.-.-", "" ], [ "Q9VYQ7-1", "1.14.-.-", "" ], [ "A8JNU6-1", "1.2.4.2", "(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H(+) = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2." ], [ "A8JNU6-1", "1.2.4.2", "" ], [ "Q8MT18-1", "1.1.1.41", "D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH." ], [ "Q7JZB1-1", "1.4.3.3", "a D-alpha-amino acid + H2O + O2 = a 2-oxocarboxylate + H2O2 + NH4(+)." ], [ "Q9W459-1", "1.2.1.84", "2 H(+) + hexadecanoyl-CoA + 2 NADPH = CoA + hexadecan-1-ol + 2 NADP(+)." ], [ "Q9W459-1", "1.2.1.84", "" ], [ "Q9VG40-1", "1.14.-.-", "" ], [ "Q9VIZ3-1", "3.6.4.13", "ATP + H2O = ADP + H(+) + phosphate." ], [ "Q9VG42-1", "2.1.1.20", "glycine + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + sarcosine." ], [ "Q9VG42-1", "2.1.1.20", "" ], [ "Q05825-1", "7.1.2.2", "ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate." ], [ "Q05825-1", "7.1.2.2", "" ], [ "P27619-1", "3.6.5.5", "GTP + H2O = GDP + H(+) + phosphate." ], [ "P27619-1", "3.6.5.5", "" ], [ "P45843-1", "7.6.2.-", "" ], [ "Q9VYQ3-1", "3.4.19.12", "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)." ], [ "Q9VYQ3-1", "3.4.19.12", "" ], [ "Q9VKZ8-1", "3.4.19.12", "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)." ], [ "Q9VKZ8-1", "3.4.19.12", "" ], [ "A0A0B4K692-1", "3.4.24.11", "Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'." ], [ "A0A0B4K692-1", "3.4.24.11", "" ], [ "P30189-1", "5.6.2.1", "ATP-independent breakage of single-stranded DNA, followed by passage and rejoining." ], [ "P30189-1", "5.6.2.1", "" ], [ "Q9VFJ3-1", "3.4.21.108", "Cleavage of non-polar aliphatic amino-acids at the P1 position, with a preference for Val, Ile and Met. At the P2 and P3 positions, Arg is selected most strongly with a secondary preference for other hydrophilic residues." ], [ "Q9VFJ3-1", "3.4.21.108", "" ], [ "Q7K3B7-1", "4.1.-.-", "" ], [ "Q8IA42-1", "2.4.1.-", "" ], [ "B7Z001-1", "1.-.-.-", "" ], [ "B7Z001-1", "2.3.1.41", "a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]." ], [ "B7Z001-1", "2.3.1.85", "acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+)." ], [ "P40793-1", "3.6.5.2", "GTP + H2O = GDP + H(+) + phosphate." ], [ "P40793-1", "3.6.5.2", "" ], [ "Q8SWX4-1", "3.4.11.-", "" ], [ "P41043-1", "5.3.99.2", "prostaglandin H2 = prostaglandin D2." ], [ "P41043-1", "1.11.1.9", "2 glutathione + H2O2 = glutathione disulfide + 2 H2O." ], [ "P41043-1", "2.5.1.18", "glutathione + RX = a halide anion + an S-substituted glutathione + H(+)." ], [ "Q9VTD4-1", "1.14.19.1", "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O." ], [ "Q7K3B9-1", "2.1.1.346", "adenosine in U6 snRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine in U6 snRNA + S-adenosyl-L-homocysteine." ], [ "Q7K3B9-1", "2.1.1.346", "" ], [ "Q9VYQ8-1", "3.4.19.12", "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)." ], [ "Q9VYQ8-1", "3.4.19.12", "" ], [ "Q9VRP3-1", "1.8.1.9", "[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH." ], [ "E2QD98-1", "2.7.4.8", "ATP + dGMP = ADP + dGDP." ], [ "P07140-1", "3.1.1.-", "" ], [ "Q03042-1", "2.7.11.12", "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]." ], [ "Q03042-1", "2.7.11.12", "" ], [ "Q9VL68-1", "4.2.1.17", "a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O." ], [ "Q9VL68-1", "5.3.3.8", "a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA." ], [ "Q9VSZ5-1", "2.7.7.78", "GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate + GDP + H(+)." ], [ "Q9VSZ5-1", "2.7.7.78", "" ], [ "Q07152-1", "1.1.1.205", "H2O + IMP + NAD(+) = H(+) + NADH + XMP." ], [ "Q07152-1", "1.1.1.205", "" ], [ "Q9VA02-1", "1.2.4.2", "(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H(+) = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2." ], [ "Q9VA02-1", "1.2.4.2", "" ], [ "Q9V7Y2-1", "4.1.2.27", "sphinganine 1-phosphate = hexadecanal + phosphoethanolamine." ], [ "Q9V7Y2-1", "4.1.2.27", "" ], [ "P55824-1", "3.4.19.12", "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)." ], [ "P55824-1", "3.4.19.12", "" ], [ "Q9VA09-1", "4.6.1.2", "GTP = 3',5'-cyclic GMP + diphosphate." ], [ "Q9VA09-1", "4.6.1.2", "" ], [ "Q7KVJ6-1", "6.2.1.3", "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate." ], [ "H8F4T3-1", "3.1.1.17", "D-glucono-1,5-lactone + H2O = D-gluconate + H(+)." ], [ "Q9VUV4-1", "2.7.11.26", "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein]." ], [ "Q6NN40-1", "2.1.1.-", "" ], [ "Q6NN40-1", "2.1.1.354", "L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine." ], [ "Q7KRY6-1", "2.7.11.1", "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]." ], [ "Q7KRY6-1", "2.7.11.1", "" ], [ "Q6WV20-1", "2.4.1.41", "L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP." ], [ "Q6WV20-1", "2.4.1.41", "" ], [ "B7YZF8-1", "7.6.2.1", "ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2." ], [ "B7YZF8-1", "7.6.2.1", "" ], [ "P40421-1", "3.1.3.16", "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate." ], [ "P40421-1", "3.1.3.16", "" ], [ "A1ZBC4-1", "2.7.11.1", "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]." ], [ "A1ZBC4-1", "2.7.11.1", "" ], [ "Q9VBR6-1", "3.2.1.-", "" ], [ "Q9VX10-1", "1.8.98.2", "[protein]-dithiol + ATP + S-hydroxy-S-oxy-L-cysteinyl-[peroxiredoxin] = [protein]-disulfide + ADP + phosphate + S-hydroxy-L-cysteinyl-[peroxiredoxin]." ], [ "Q9VX10-1", "1.8.98.2", "" ], [ "Q8MZG9-1", "1.1.1.300", "all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH." ] ] }, "readme": "Name\n - Fruitfly Protein Enzyme Annotation (UniProtKB)\n\nVersion\n - v-2.1.1\n\nCreated on\n - 2022-08-30T14:44:26.008676\n\nModified on\n - 2022-09-26T09:08:12.523790\n\nCreated by\n - Jeet Vora [jeetvora@gwu.edu], Robel Kahsay [rykahsay@gwu.edu], Karina Martinez [karinamartinez@gwu.edu], Jingyue Wu [jingyue.wu@email.gwu.edu]\n\nAuthors\n - Maria Martin [martin@ebi.ac.uk], Preethi Vasudev [pvasudev@ebi.ac.uk]\n\nChecksum\n - \n\nUsability Domain\n - The Fruitfly Protein Enzyme Annotation (UniProtKB) dataset contains fruitfly [taxid:7227] enzyme annotations for UniProtKB canonical accessions. The dataset contains ec numbers and enzyme activity that describes the enzymatic reactions. The dataset is derived form 2019-09 UniprotKB release. If you use this dataset please give proper attribution to UniProtKB and GlyGen\n\nDescription Domain\n Keywords\n - enzyme annotation\n - enzyme \n - UniProtKB\n - enzyme activity\n - EC number\n\n Pipeline Steps\n - Step-1: The script extracts the enzyme annotation triples from the triplestore for the UniProtKB canonical sequnces asnd extracts as a dataset in a csv format\n\nExecution Domain\n Scripts - https://github.com/glygener/glygen-backend-integration/blob/master/dataset-maker/make-protein-dataset.py\n\n\n Software Prerequisites\n Name: Python\n Version: 2.7.5\n URI: https://www.python.org/download/releases/2.7.5/\n\nI/O Domain\n Input Subdomain\n Name: uniprot-proteome-drosophila-melanogaster.nt\n URI: /data/shared/glyds/downloads/ebi/2023_02/uniprot-proteome-drosophila-melanogaster.nt\n Output Subdomain\n Name: fruitfly_protein_enzyme_annotation_uniprotkb.csv\n URI: https:/data.glygen.org/ln2releases/data/v-2.1.1/reviewed/fruitfly_protein_enzyme_annotation_uniprotkb.csv\n Name: fruitfly_protein_enzyme_annotation_uniprotkb.stat.csv\n URI: https:/data.glygen.org/ln2releases/data/v-2.1.1/reviewed/fruitfly_protein_enzyme_annotation_uniprotkb.stat.csv\n\nFields\n Name: \"uniprotkb_canonical_ac\"\n Description: \"\"\n Unique Values: \"2695\"\n Name: \"enzyme_ec\"\n Description: \"Enzyme Commision number assigned to an enzyme by Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB)\"\n Unique Values: \"939\"\n Name: \"enzyme_activity\"\n Description: \"The catalytic reaction activity of an enzyme in UniProtKB\"\n Unique Values: \"811\"", "downloadurl": "/ln2data/releases/data/v-2.1.1/reviewed/fruitfly_protein_enzyme_annotation_uniprotkb.csv" }