{ "bcoid": "GLY_000324", "title": "Mouse Protein Enzyme Annotation (UniProtKB)", "description": "The Mouse Protein Enzyme Annotation (UniProtKB) dataset contains mouse [taxid:10090] enzyme annotations ...", "filename": "mouse_protein_enzyme_annotation_uniprotkb.csv", "filetype": "csv", "categories": { "species": [ "Mus musculus" ], "molecule": [ "Protein" ], "tags": [ "enzyme annotation" ], "file_type": [ "csv" ], "status": [ "Reviewed" ], "scope": [ "internal" ] }, "minitable": { "content": [ [ "A2RSX7-1...", "1.14.11.42..." ], [ "A2RSX7-1...", "1.14.11.42..." ] ], "headers": [ "uniprotkb_ca...", "enzyme_ec..." ], "colwidth": [ "40%", "20%" ] }, "sampledata": { "type": "table", "data": [ [ { "type": "string", "label": "uniprotkb_canonical_ac" }, { "type": "string", "label": "enzyme_ec" }, { "type": "string", "label": "enzyme_activity" } ], [ "A2RSX7-1", "1.14.11.42", "2-oxoglutarate + 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + O2 = 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + CO2 + succinate." ], [ "A2RSX7-1", "1.14.11.42", "" ], [ "G5E870-1", "2.3.2.26", "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine." ], [ "G5E870-1", "2.3.2.26", "" ], [ "Q6NSR3-1", "2.7.11.-", "" ], [ "Q6NSR8-1", "3.4.11.-", "" ], [ "P83855-1", "4.6.1.1", "ATP = 3',5'-cyclic AMP + diphosphate." ], [ "P83855-1", "4.6.1.1", "" ], [ "O70250-1", "5.4.2.11", "(2R)-2,3-bisphosphoglycerate + H2O = (2R)-3-phosphoglycerate + phosphate." ], [ "O70250-1", "5.4.2.4", "(2R)-3-phospho-glyceroyl phosphate = (2R)-2,3-bisphosphoglycerate + H(+)." ], [ "O70250-1", "5.4.2.11", "" ], [ "O70250-1", "5.4.2.4", "" ], [ "O70252-1", "1.14.14.18", "heme b + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = biliverdin IXalpha + CO + Fe(2+) + H(+) + 3 H2O + 3 oxidized [NADPH--hemoprotein reductase]." ], [ "O70252-1", "1.14.14.18", "" ], [ "P12791-1", "1.14.14.1", "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]." ], [ "P12791-1", "1.14.14.1", "" ], [ "Q9WUD1-1", "2.3.2.27", "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine." ], [ "Q9WUD1-1", "2.3.2.27", "" ], [ "O54785-1", "2.7.11.1", "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]." ], [ "O54785-1", "2.7.11.1", "" ], [ "Q9JKK8-1", "2.7.11.1", "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]." ], [ "Q9JKK8-1", "2.7.11.1", "" ], [ "O54784-1", "2.7.11.1", "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]." ], [ "O54784-1", "2.7.11.1", "" ], [ "Q811W2-1", "1.14.13.-", "" ], [ "Q9CXG3-1", "5.2.1.8", "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)." ], [ "Q9CXG3-1", "5.2.1.8", "" ], [ "O55047-1", "2.7.11.1", "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]." ], [ "O55047-1", "2.7.11.1", "" ], [ "Q68FL6-1", "6.1.1.10", "ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)." ], [ "Q68FL6-1", "6.1.1.10", "" ], [ "Q6VVW5-1", "4.6.1.2", "GTP = 3',5'-cyclic GMP + diphosphate." ], [ "Q6VVW5-1", "4.6.1.2", "" ], [ "O35400-1", "2.8.2.-", "" ], [ "O35855-1", "2.6.1.42", "2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate." ], [ "O35855-1", "2.6.1.42", "" ], [ "P03899-1", "7.1.1.2", "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+)." ], [ "P03899-1", "7.1.1.2", "" ], [ "P48964-1", "3.1.3.48", "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate." ], [ "P48964-1", "3.1.3.48", "" ], [ "P48967-1", "3.1.3.48", "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate." ], [ "P48967-1", "3.1.3.48", "" ], [ "Q8BY87-1", "3.4.19.12", "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)." ], [ "Q8BY87-1", "3.4.19.12", "" ], [ "Q9Z0S1-1", "3.1.3.7", "adenosine 3',5'-bisphosphate + H2O = AMP + phosphate." ], [ "Q9Z0S1-1", "3.1.3.7", "" ], [ "Q80V72-1", "2.7.-.-", "" ], [ "P52479-1", "3.4.19.12", "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)." ], [ "P52479-1", "3.4.19.12", "" ], [ "P25688-1", "1.7.3.3", "H2O + O2 + urate = 5-hydroxyisourate + H2O2." ], [ "P25688-1", "1.7.3.3", "" ], [ "Q8BLF1-1", "3.1.1.-", "" ], [ "Q8BLF1-1", "3.1.1.71", "a 1-O-alkyl-2-acetyl-sn-glycerol + H2O = 1-O-alkyl-sn-glycerol + acetate + H(+)." ], [ "Q8BLF2-1", "2.7.11.22", "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]." ], [ "Q8BLF2-1", "2.7.11.22", "" ], [ "Q8BTW8-1", "2.8.4.3", "[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine." ], [ "Q8BTW8-1", "2.8.4.3", "" ], [ "Q8BTW9-1", "2.7.11.1", "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]." ], [ "Q8BTW9-1", "2.7.11.1", "" ], [ "Q3UU43-1", "2.4.1.-", "" ], [ "Q9DBC3-1", "2.1.1.57", "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine." ], [ "Q9DBC3-1", "2.1.1.57", "" ], [ "Q61409-1", "3.1.4.17", "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+)." ], [ "Q61409-1", "3.1.4.17", "" ], [ "Q80YU0-1", "3.-.-.-", "" ], [ "Q3TYU2-1", "7.2.2.-", "" ], [ "P21180-1", "3.4.21.43", "Selective cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha-chain to form C5a and C5b." ], [ "P21180-1", "3.4.21.43", "" ], [ "P62908-1", "4.2.99.18", "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)." ], [ "P62908-1", "4.2.99.18", "" ], [ "Q5K2P8-1", "3.4.21.-", "" ], [ "Q3UFF7-1", "3.1.2.22", "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein]." ], [ "Q3UFF7-1", "3.1.2.22", "" ], [ "Q14BT6-1", "2.4.1.-", "" ], [ "Q8BUM9-1", "3.4.19.12", "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)." ], [ "Q8BUM9-1", "3.4.19.12", "" ], [ "Q8K330-1", "3.1.3.16", "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate." ], [ "Q8K330-1", "3.1.3.16", "" ], [ "Q99MQ3-1", "2.7.11.1", "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]." ], [ "Q99MQ3-1", "2.7.11.1", "" ], [ "P70419-1", "2.4.1.41", "L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP." ], [ "P70419-1", "2.4.1.41", "" ], [ "Q8C078-1", "2.7.11.17", "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]." ], [ "Q8C078-1", "2.7.11.17", "" ] ] }, "readme": "Name\n - Mouse Protein Enzyme Annotation (UniProtKB)\n\nVersion\n - v-2.1.1\n\nCreated on\n - 2019-12-01T15:59:48.968222\n\nModified on\n - 2022-09-26T09:05:27.699987\n\nCreated by\n - Jeet Vora [jeetvora@gwu.edu], Robel Kahsay [rykahsay@gwu.edu], Karina Martinez [karinamartinez@gwu.edu], Jingyue Wu [jingyue.wu@email.gwu.edu]\n\nAuthors\n - Maria Martin [martin@ebi.ac.uk], Preethi Vasudev [pvasudev@ebi.ac.uk]\n\nChecksum\n - \n\nUsability Domain\n - The Mouse Protein Enzyme Annotation (UniProtKB) dataset contains mouse [taxid:10090] enzyme annotations for UniProtKB canonical accessions. The dataset contains ec numbers and enzyme activity that describes the enzymatic reactions. The dataset is derived form 2019-09 UniprotKB release. If you use this dataset please give proper attribution to UniProtKB and GlyGen\n\nDescription Domain\n Keywords\n - enzyme annotation\n - enzyme \n - UniProtKB\n - enzyme activity\n - EC number\n\n Pipeline Steps\n - Step-1: The script extracts the enzyme annotation triples from the triplestore for the UniProtKB canonical sequences and extracts as a dataset in a csv format\n\nExecution Domain\n Scripts - https://github.com/glygener/glygen-backend-integration/blob/master/dataset-maker/make-protein-dataset.py\n\n\n Software Prerequisites\n Name: Python\n Version: 2.7.5\n URI: https://www.python.org/download/releases/2.7.5/\n\nI/O Domain\n Input Subdomain\n Name: uniprot-proteome-mus-musculus.nt\n URI: /data/shared/glyds/downloads/ebi/2023_02/uniprot-proteome-mus-musculus.nt\n Output Subdomain\n Name: mouse_protein_enzyme_annotation_uniprotkb.csv\n URI: https:/data.glygen.org/ln2releases/data/v-2.1.1/reviewed/mouse_protein_enzyme_annotation_uniprotkb.csv\n Name: mouse_protein_enzyme_annotation_uniprotkb.stat.csv\n URI: https:/data.glygen.org/ln2releases/data/v-2.1.1/reviewed/mouse_protein_enzyme_annotation_uniprotkb.stat.csv\n\nFields\n Name: \"uniprotkb_canonical_ac\"\n Description: \"\"\n Unique Values: \"4414\"\n Name: \"enzyme_ec\"\n Description: \"Enzyme Commision number assigned to an enzyme by Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB)\"\n Unique Values: \"1590\"\n Name: \"enzyme_activity\"\n Description: \"The catalytic reaction activity of an enzyme in UniProtKB\"\n Unique Values: \"1429\"", "downloadurl": "/ln2data/releases/data/v-2.1.1/reviewed/mouse_protein_enzyme_annotation_uniprotkb.csv" }