{
    "bcoid": "GLY_000249",
    "title": "Rat Protein Function (NCBI RefSeq)",
    "description": "The Rat Protein Function (NCBI RefSeq) dataset contains biological function annotation of rat [taxid:10116] ...",
    "filename": "rat_protein_function_refseq.csv",
    "filetype": "csv",
    "categories": {
        "species": [
            "Rattus norvegicus"
        ],
        "molecule": [
            "Protein"
        ],
        "tags": [
            "Protein Function"
        ],
        "file_type": [
            "csv"
        ],
        "status": [
            "Reviewed"
        ],
        "scope": [
            "internal"
        ]
    },
    "minitable": {
        "content": [
            [
                "A2VCW5-1...",
                "NP_620209..."
            ],
            [
                "A2VCW5-1...",
                "NP_620209..."
            ]
        ],
        "headers": [
            "uniprotkb_ca...",
            "refseq_ac..."
        ],
        "colwidth": [
            "40%",
            "20%"
        ]
    },
    "sampledata": {
        "type": "table",
        "data": [
            [
                {
                    "type": "string",
                    "label": "uniprotkb_canonical_ac"
                },
                {
                    "type": "string",
                    "label": "refseq_ac"
                },
                {
                    "type": "string",
                    "label": "xref_key"
                },
                {
                    "type": "string",
                    "label": "xref_id"
                },
                {
                    "type": "string",
                    "label": "annotation"
                }
            ],
            [
                "A2VCW5-1",
                "NP_620209",
                "protein_xref_refseq",
                "NP_620209",
                "SNAT5/SN2 expression is coordinated with that of other proteins necessary for the operation of glutamatergic synapses"
            ],
            [
                "A2VCW5-1",
                "NP_620209",
                "protein_xref_pubmed",
                "24333324",
                "SNAT5/SN2 expression is coordinated with that of other proteins necessary for the operation of glutamatergic synapses"
            ],
            [
                "A2VCW5-1",
                "NP_620209",
                "protein_xref_refseq",
                "NP_620209",
                "SN2 doubles as a transmitter precursor furnisher and a potential regulator of NMDA receptors."
            ],
            [
                "A2VCW5-1",
                "NP_620209",
                "protein_xref_pubmed",
                "22821889",
                "SN2 doubles as a transmitter precursor furnisher and a potential regulator of NMDA receptors."
            ],
            [
                "A2VCW5-1",
                "NP_620209",
                "protein_xref_refseq",
                "NP_620209",
                "The effect of lipopolysaccharides on system N expression occurs not only at the protein level, but also at the mRNA level"
            ],
            [
                "A2VCW5-1",
                "NP_620209",
                "protein_xref_pubmed",
                "20036385",
                "The effect of lipopolysaccharides on system N expression occurs not only at the protein level, but also at the mRNA level"
            ],
            [
                "A2VCW5-1",
                "NP_620209",
                "protein_xref_refseq",
                "NP_620209",
                "PH-sensitive System A (SNAT2) and System N (SNAT5) amino acid transporter activity allosteric regulation involves a conserved histidine residue"
            ],
            [
                "A2VCW5-1",
                "NP_620209",
                "protein_xref_pubmed",
                "16629640",
                "PH-sensitive System A (SNAT2) and System N (SNAT5) amino acid transporter activity allosteric regulation involves a conserved histidine residue"
            ],
            [
                "A2VCW5-1",
                "NP_620209",
                "protein_xref_refseq",
                "NP_620209",
                "This transporter is likely to be involved in glutamatergic pathways in the brain."
            ],
            [
                "A2VCW5-1",
                "NP_620209",
                "protein_xref_pubmed",
                "15390093",
                "This transporter is likely to be involved in glutamatergic pathways in the brain."
            ],
            [
                "Q76IC6-1",
                "NP_998792",
                "protein_xref_refseq",
                "NP_998792",
                "NIDD mRNA was predominantly expressed in nociceptive neurons and in neurons of the spinal dorsal horn and the number of NIDD-positive neurons in the corresponding dorsal root ganglia or spinal cord increased following induction of chronic hyperalgesia."
            ],
            [
                "Q76IC6-1",
                "NP_998792",
                "protein_xref_pubmed",
                "17899403",
                "NIDD mRNA was predominantly expressed in nociceptive neurons and in neurons of the spinal dorsal horn and the number of NIDD-positive neurons in the corresponding dorsal root ganglia or spinal cord increased following induction of chronic hyperalgesia."
            ],
            [
                "Q76IC6-1",
                "NP_998792",
                "protein_xref_refseq",
                "NP_998792",
                "NIDD gene expression may be involved in the different pathological conditions including nerve regeneration, neuron loss or survival, and even pain processes."
            ],
            [
                "Q76IC6-1",
                "NP_998792",
                "protein_xref_pubmed",
                "17873365",
                "NIDD gene expression may be involved in the different pathological conditions including nerve regeneration, neuron loss or survival, and even pain processes."
            ],
            [
                "Q76IC6-1",
                "NP_998792",
                "protein_xref_refseq",
                "NP_998792",
                "These results suggest that NIDD plays an important role in the regulation of the nitric oxide signaling pathway at postsynaptic sites through targeting of nueronal nitric oxide synthase to the postsynaptic membrane."
            ],
            [
                "Q76IC6-1",
                "NP_998792",
                "protein_xref_pubmed",
                "15105416",
                "These results suggest that NIDD plays an important role in the regulation of the nitric oxide signaling pathway at postsynaptic sites through targeting of nueronal nitric oxide synthase to the postsynaptic membrane."
            ],
            [
                "Q71RP1-1",
                "NP_072127",
                "protein_xref_refseq",
                "NP_072127",
                "We identified Hpse as a previously unexplored candidate, being up-regulated following injury. We confirmed these results and demonstrated inhibition of Hpse led to an acceleration of axonal degeneration, accompanied by an increase in b-catenin Publication Status: Online-Only"
            ],
            [
                "Q71RP1-1",
                "NP_072127",
                "protein_xref_pubmed",
                "29581478",
                "We identified Hpse as a previously unexplored candidate, being up-regulated following injury. We confirmed these results and demonstrated inhibition of Hpse led to an acceleration of axonal degeneration, accompanied by an increase in b-catenin Publication Status: Online-Only"
            ],
            [
                "Q71RP1-1",
                "NP_072127",
                "protein_xref_refseq",
                "NP_072127",
                "Heparanase plays an important role in mediating the neuroinflammatory response after subarachnoid hemorrhage. Publication Status: Online-Only"
            ],
            [
                "Q71RP1-1",
                "NP_072127",
                "protein_xref_pubmed",
                "28720149",
                "Heparanase plays an important role in mediating the neuroinflammatory response after subarachnoid hemorrhage. Publication Status: Online-Only"
            ],
            [
                "Q71RP1-1",
                "NP_072127",
                "protein_xref_refseq",
                "NP_072127",
                "Endothelial cell-to-cardiomyocyte transfer of heparanase to modulates the cardiomyocyte cell death signature. This mechanism was observed in the acutely diabetic heart, and its interruption following chronic diabetes may contribute towards the development of diabetic cardiomyopathy."
            ],
            [
                "Q71RP1-1",
                "NP_072127",
                "protein_xref_pubmed",
                "27979811",
                "Endothelial cell-to-cardiomyocyte transfer of heparanase to modulates the cardiomyocyte cell death signature. This mechanism was observed in the acutely diabetic heart, and its interruption following chronic diabetes may contribute towards the development of diabetic cardiomyopathy."
            ],
            [
                "Q71RP1-1",
                "NP_072127",
                "protein_xref_refseq",
                "NP_072127",
                "The expression of the gene for heparanase was increased in the right and left ventricles after treatment with monocrotaline"
            ],
            [
                "Q71RP1-1",
                "NP_072127",
                "protein_xref_pubmed",
                "26638897",
                "The expression of the gene for heparanase was increased in the right and left ventricles after treatment with monocrotaline"
            ],
            [
                "Q71RP1-1",
                "NP_072127",
                "protein_xref_refseq",
                "NP_072127",
                "Inhibiting heparanase function could offer a new strategy for managing cardiomyopathy observed after diabetes."
            ],
            [
                "Q71RP1-1",
                "NP_072127",
                "protein_xref_pubmed",
                "24608441",
                "Inhibiting heparanase function could offer a new strategy for managing cardiomyopathy observed after diabetes."
            ],
            [
                "Q71RP1-1",
                "NP_072127",
                "protein_xref_refseq",
                "NP_072127",
                "Characterization of rat heparanase activity in a parathyroid cell line"
            ],
            [
                "Q71RP1-1",
                "NP_072127",
                "protein_xref_pubmed",
                "12077130",
                "Characterization of rat heparanase activity in a parathyroid cell line"
            ],
            [
                "Q71RP1-1",
                "NP_072127",
                "protein_xref_refseq",
                "NP_072127",
                "Characterization of a novel intracellular heparanase that has a FERM domain."
            ],
            [
                "Q71RP1-1",
                "NP_072127",
                "protein_xref_pubmed",
                "11988100",
                "Characterization of a novel intracellular heparanase that has a FERM domain."
            ],
            [
                "Q6REY9-1",
                "NP_998794",
                "protein_xref_refseq",
                "NP_998794",
                "RARhoGAP expression was found in differentiating male germ cells and in the testis, suggesting that it may be involved in rearrangements of the cytoskeleton and cell signaling events that occur during spermatogenesis."
            ],
            [
                "Q6REY9-1",
                "NP_998794",
                "protein_xref_pubmed",
                "15234003",
                "RARhoGAP expression was found in differentiating male germ cells and in the testis, suggesting that it may be involved in rearrangements of the cytoskeleton and cell signaling events that occur during spermatogenesis."
            ],
            [
                "Q9QY10-1",
                "NP_072125",
                "protein_xref_refseq",
                "NP_072125",
                "FGF-BP is an early response gene after spinal cord injury and that its upregulation in regenerating spinal cord tissue may provide a molecular mechanism for enhancing the initial FGF2-mediated neurotrophic effects occurring after such tissue damage"
            ],
            [
                "Q9QY10-1",
                "NP_072125",
                "protein_xref_pubmed",
                "17553847",
                "FGF-BP is an early response gene after spinal cord injury and that its upregulation in regenerating spinal cord tissue may provide a molecular mechanism for enhancing the initial FGF2-mediated neurotrophic effects occurring after such tissue damage"
            ],
            [
                "Q9Z1Z6-1",
                "NP_072128",
                "protein_xref_refseq",
                "NP_072128",
                "Distinct functions for mGluR2 and mGluR3 and dynamic regulation of mGluR3 by PP2C"
            ],
            [
                "Q9Z1Z6-1",
                "NP_072128",
                "protein_xref_pubmed",
                "14663150",
                "Distinct functions for mGluR2 and mGluR3 and dynamic regulation of mGluR3 by PP2C"
            ],
            [
                "Q9EPZ7-1",
                "NP_445893",
                "protein_xref_refseq",
                "NP_445893",
                "CRISRP/Cas9-mediated knockout of Mct8 reveals a functional involvement of Mct8 in testis and sperm development in a rat. Erratum:[Sci Rep. 2020 Nov 11;10(1):19967. PMID: 33177632] Publication Status: Online-Only"
            ],
            [
                "Q9EPZ7-1",
                "NP_445893",
                "protein_xref_pubmed",
                "32636400",
                "CRISRP/Cas9-mediated knockout of Mct8 reveals a functional involvement of Mct8 in testis and sperm development in a rat. Erratum:[Sci Rep. 2020 Nov 11;10(1):19967. PMID: 33177632] Publication Status: Online-Only"
            ],
            [
                "Q9EPZ7-1",
                "NP_445893",
                "protein_xref_refseq",
                "NP_445893",
                "Differential expression and immunoreactivity of thyroid hormone transporters MCT8 and OATP1C1 in rat ovary."
            ],
            [
                "Q9EPZ7-1",
                "NP_445893",
                "protein_xref_pubmed",
                "31561916",
                "Differential expression and immunoreactivity of thyroid hormone transporters MCT8 and OATP1C1 in rat ovary."
            ],
            [
                "Q9EPZ7-1",
                "NP_445893",
                "protein_xref_refseq",
                "NP_445893",
                "Prenatal exposure to monoclonal antibody brain-specific anion transporter-1 blocks brain-specific anion transporter-1 and limits T4 influx to the brain. This impairs the cognitive function in exposed progeny in the post-natal life."
            ],
            [
                "Q9EPZ7-1",
                "NP_445893",
                "protein_xref_pubmed",
                "28688524",
                "Prenatal exposure to monoclonal antibody brain-specific anion transporter-1 blocks brain-specific anion transporter-1 and limits T4 influx to the brain. This impairs the cognitive function in exposed progeny in the post-natal life."
            ],
            [
                "Q9EPZ7-1",
                "NP_445893",
                "protein_xref_refseq",
                "NP_445893",
                "This study demonstrated that reduction of the Mct8 mRNA expression in hippocampus of thyroidectomized Wistar rats."
            ],
            [
                "Q9EPZ7-1",
                "NP_445893",
                "protein_xref_pubmed",
                "26861177",
                "This study demonstrated that reduction of the Mct8 mRNA expression in hippocampus of thyroidectomized Wistar rats."
            ],
            [
                "Q9EPZ7-1",
                "NP_445893",
                "protein_xref_refseq",
                "NP_445893",
                "The data demonstrate that OATP1c1 and MCT8 expression are regulated in a parallel manner during inflammation at the blood-brain barrier of rodents."
            ],
            [
                "Q9EPZ7-1",
                "NP_445893",
                "protein_xref_pubmed",
                "25594699",
                "The data demonstrate that OATP1c1 and MCT8 expression are regulated in a parallel manner during inflammation at the blood-brain barrier of rodents."
            ],
            [
                "P20646-1",
                "NP_001128373",
                "protein_xref_refseq",
                "NP_001128373",
                "PAP-immunoreactivity was present in type I and one of type III taste cells of taste buds. Thus, it is suggested that PAP might be a responsible ectoenzyme for metabolism of extracellular nucleotides, being involved in the regulation of taste signaling in taste buds. Publication Status: Online-Only"
            ],
            [
                "P20646-1",
                "NP_001128373",
                "protein_xref_pubmed",
                "27348306",
                "PAP-immunoreactivity was present in type I and one of type III taste cells of taste buds. Thus, it is suggested that PAP might be a responsible ectoenzyme for metabolism of extracellular nucleotides, being involved in the regulation of taste signaling in taste buds. Publication Status: Online-Only"
            ],
            [
                "P20646-1",
                "NP_001128373",
                "protein_xref_refseq",
                "NP_001128373",
                "Acpp plays an important role in growth and development of the penis of rats, and its expression is modulated at epigenomic levels via specific miRs"
            ],
            [
                "P20646-1",
                "NP_001128373",
                "protein_xref_pubmed",
                "25482440",
                "Acpp plays an important role in growth and development of the penis of rats, and its expression is modulated at epigenomic levels via specific miRs"
            ],
            [
                "P20646-1",
                "NP_001128373",
                "protein_xref_refseq",
                "NP_001128373",
                "Our findings suggest that the decrease of PAP in dorsal root ganglion neurons is involved in pathophysiological mechanisms of neuropathic pain Publication Status: Online-Only"
            ],
            [
                "P20646-1",
                "NP_001128373",
                "protein_xref_pubmed",
                "25674224",
                "Our findings suggest that the decrease of PAP in dorsal root ganglion neurons is involved in pathophysiological mechanisms of neuropathic pain Publication Status: Online-Only"
            ],
            [
                "B5DFI9-1",
                "NP_001100051",
                "protein_xref_refseq",
                "NP_001100051",
                "Epigenetic Metabolic Reprogramming of Right Ventricular Fibroblasts in Pulmonary Arterial Hypertension: A Pyruvate Dehydrogenase Kinase-Dependent Shift in Mitochondrial Metabolism Promotes Right Ventricular Fibrosis."
            ],
            [
                "B5DFI9-1",
                "NP_001100051",
                "protein_xref_pubmed",
                "32216531",
                "Epigenetic Metabolic Reprogramming of Right Ventricular Fibroblasts in Pulmonary Arterial Hypertension: A Pyruvate Dehydrogenase Kinase-Dependent Shift in Mitochondrial Metabolism Promotes Right Ventricular Fibrosis."
            ],
            [
                "O88794-1",
                "NP_072123",
                "protein_xref_refseq",
                "NP_072123",
                "PNPO may play a role in activity-dependent regulation of PLP level in the brain, which is involved in LTP induction and paired-pulse facilitation but not in enhancement of GABAergic inhibition."
            ],
            [
                "O88794-1",
                "NP_072123",
                "protein_xref_pubmed",
                "18680158",
                "PNPO may play a role in activity-dependent regulation of PLP level in the brain, which is involved in LTP induction and paired-pulse facilitation but not in enhancement of GABAergic inhibition."
            ],
            [
                "O88794-1",
                "NP_072123",
                "protein_xref_refseq",
                "NP_072123",
                "Pnpo is a candidate gene responsible for hypertension in Dahl-S rats"
            ],
            [
                "O88794-1",
                "NP_072123",
                "protein_xref_pubmed",
                "14697241",
                "Pnpo is a candidate gene responsible for hypertension in Dahl-S rats"
            ],
            [
                "P62634-1",
                "NP_072120",
                "protein_xref_refseq",
                "NP_072120",
                "Findings showed that ZNF9 is ubiquitously expressed in mammalian tissues, and that its signal is not substantially modified in myotonic dystrophy type 2 muscles"
            ],
            [
                "P62634-1",
                "NP_072120",
                "protein_xref_pubmed",
                "20102514",
                "Findings showed that ZNF9 is ubiquitously expressed in mammalian tissues, and that its signal is not substantially modified in myotonic dystrophy type 2 muscles"
            ],
            [
                "P62634-1",
                "NP_072120",
                "protein_xref_refseq",
                "NP_072120",
                "Znf9 haploinsufficiency contributes to the myotonic dystrophy phenotype in Znf9+/- mice."
            ],
            [
                "P62634-1",
                "NP_072120",
                "protein_xref_pubmed",
                "17335846",
                "Znf9 haploinsufficiency contributes to the myotonic dystrophy phenotype in Znf9+/- mice."
            ],
            [
                "P97682-1",
                "NP_072126",
                "protein_xref_refseq",
                "NP_072126",
                "Peripheral blood ESM-1 mRNA and ESM-1 protein expression in kidney grafts can reflect the severity of endothelial cell impairment"
            ],
            [
                "P97682-1",
                "NP_072126",
                "protein_xref_pubmed",
                "23850961",
                "Peripheral blood ESM-1 mRNA and ESM-1 protein expression in kidney grafts can reflect the severity of endothelial cell impairment"
            ],
            [
                "Q78P75-1",
                "NP_542428",
                "protein_xref_refseq",
                "NP_542428",
                "Results suggest that feeding increases excitatory synaptic input on paraventricular nucleus oxytocin neurons via mechanisms involving DYNLL2 upregulation and NMDA receptor-mediated synaptic reorganization."
            ],
            [
                "Q78P75-1",
                "NP_542428",
                "protein_xref_pubmed",
                "26344333",
                "Results suggest that feeding increases excitatory synaptic input on paraventricular nucleus oxytocin neurons via mechanisms involving DYNLL2 upregulation and NMDA receptor-mediated synaptic reorganization."
            ],
            [
                "Q6PCU8-1",
                "NP_072129",
                "protein_xref_refseq",
                "NP_072129",
                "We describe characterization of the complexes I purified from five rat tissues and from a rat hepatoma cell line. We identify a~50kDa isoform of subunit NDUFV3, for which the canonical isoform is only ~10kDa in size."
            ],
            [
                "Q6PCU8-1",
                "NP_072129",
                "protein_xref_pubmed",
                "27940020",
                "We describe characterization of the complexes I purified from five rat tissues and from a rat hepatoma cell line. We identify a~50kDa isoform of subunit NDUFV3, for which the canonical isoform is only ~10kDa in size."
            ],
            [
                "Q6PCU8-1",
                "NP_072129",
                "protein_xref_refseq",
                "NP_072129",
                "OBAP is mainly produced by mitochondria of parietal cells in the upper and lower parts of the gastric epithelium."
            ],
            [
                "Q6PCU8-1",
                "NP_072129",
                "protein_xref_pubmed",
                "26686297",
                "OBAP is mainly produced by mitochondria of parietal cells in the upper and lower parts of the gastric epithelium."
            ],
            [
                "D3ZBS9-1",
                "NP_001102222",
                "protein_xref_refseq",
                "NP_001102222",
                "Demonstrate that Smarcd1 is a critical node integrating the circadian clock and vascular smooth muscle cell physiological homeostasis."
            ],
            [
                "D3ZBS9-1",
                "NP_001102222",
                "protein_xref_pubmed",
                "24615205",
                "Demonstrate that Smarcd1 is a critical node integrating the circadian clock and vascular smooth muscle cell physiological homeostasis."
            ],
            [
                "Q6ZM99-1",
                "NP_998897",
                "protein_xref_refseq",
                "NP_998897",
                "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]."
            ],
            [
                "Q6ZMA0-1",
                "NP_998896",
                "protein_xref_refseq",
                "NP_998896",
                "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]."
            ],
            [
                "P06536-1",
                "NP_036708",
                "protein_xref_refseq",
                "NP_036708",
                "Regulatory Effects of Maternal Immune Activation and Environmental Enrichment on Glucocorticoid Receptor and FKBP5 Expression in Stress-sensitive Regions of the Offspring Brain."
            ],
            [
                "P06536-1",
                "NP_036708",
                "protein_xref_pubmed",
                "36116554",
                "Regulatory Effects of Maternal Immune Activation and Environmental Enrichment on Glucocorticoid Receptor and FKBP5 Expression in Stress-sensitive Regions of the Offspring Brain."
            ],
            [
                "P06536-1",
                "NP_036708",
                "protein_xref_refseq",
                "NP_036708",
                "Glucocorticoid Receptor/HCN4 Channels Interaction in Spinal Dorsal Horn Participates in the Regulation of Neuropathic Pain after Peripheral Nerve Injury in Rats."
            ],
            [
                "P06536-1",
                "NP_036708",
                "protein_xref_pubmed",
                "36214984",
                "Glucocorticoid Receptor/HCN4 Channels Interaction in Spinal Dorsal Horn Participates in the Regulation of Neuropathic Pain after Peripheral Nerve Injury in Rats."
            ],
            [
                "P06536-1",
                "NP_036708",
                "protein_xref_refseq",
                "NP_036708",
                "Hypothalamic NR3C1 DNA methylation in rats exposed to prenatal stress."
            ],
            [
                "P06536-1",
                "NP_036708",
                "protein_xref_pubmed",
                "35661969",
                "Hypothalamic NR3C1 DNA methylation in rats exposed to prenatal stress."
            ],
            [
                "P06536-1",
                "NP_036708",
                "protein_xref_refseq",
                "NP_036708",
                "Norepinephrine and Glucocorticoids Modulate Chronic Unpredictable Stress-Induced Increase in the Type 2 CRF and Glucocorticoid Receptors in Brain Structures Related to the HPA Axis Activation."
            ],
            [
                "P06536-1",
                "NP_036708",
                "protein_xref_pubmed",
                "34213722",
                "Norepinephrine and Glucocorticoids Modulate Chronic Unpredictable Stress-Induced Increase in the Type 2 CRF and Glucocorticoid Receptors in Brain Structures Related to the HPA Axis Activation."
            ],
            [
                "P06536-1",
                "NP_036708",
                "protein_xref_refseq",
                "NP_036708",
                "Amyloid beta has a role in the amyloidogenic pathway and enzymes involved both in Tau hyperphosphorylation and GR activation"
            ],
            [
                "P06536-1",
                "NP_036708",
                "protein_xref_pubmed",
                "31914623",
                "Amyloid beta has a role in the amyloidogenic pathway and enzymes involved both in Tau hyperphosphorylation and GR activation"
            ]
        ]
    },
    "readme": "Name\n   - Rat Protein Function (NCBI RefSeq)\n\nVersion\n   - v-2.1.1\n\nCreated on\n  - 2019-09-06T14:06:38.975527\n\nModified on\n   - 2022-09-26T09:04:47.890686\n\nCreated by\n   - Jeet Vora [jeetvora@gwu.edu], Robel Kahsay [rykahsay@gwu.edu], Karina Martinez [karinamartinez@gwu.edu], Jingyue Wu [jingyue.wu@email.gwu.edu]\n\nAuthors\n   - Not Applicable []\n\nChecksum\n   - \n\nUsability Domain\n   - The Rat Protein Function (NCBI RefSeq) dataset contains biological function annotation of rat [taxid:10116] genes from GeneRIF section in the NCBI RefSeq database. The dataset is derived from NCBI RefSeq Release 96, September 9, 2019. If you use this dataset please provide proper attribution to NCBI RefSeq and GlyGen. \n\nDescription Domain\n   Keywords\n   - protein function\n   - NCBI RefSeq\n   - geneRIF\n   - PMID\n\n   Pipeline Steps\n   - Step-1: The script parses the NCBI RefSeq gpff files to extract the geneRIFs that contain protein function. The script also maps RefSeq accessions to the UniProtKB Canonical accessions. \n\nExecution Domain\n   Scripts   - https://github.com/glygener/glygen-backend-integration/blob/master/dataset-maker/make-protein-dataset.py\n\n\n   Software Prerequisites\n      Name: Python\n      Version: 2.7.5\n      URI: https://www.python.org/download/releases/2.7.5/\n\nI/O Domain\n   Input Subdomain\n      Name: rat_protein_xref_refseq.csv\n      URI: https:/data.glygen.org/ln2releases/data/v-2.1.1/reviewed/rat_protein_xref_refseq.csv\n      Name: refseq_protein_all_10116.gpff\n      URI: /data/shared/glyds/downloads/ncbi/refseq/2023_04/refseq_protein_all_10116.gpff\n   Output Subdomain\n      Name: rat_protein_function_refseq.csv\n      URI: https:/data.glygen.org/ln2releases/data/v-2.1.1/reviewed/rat_protein_function_refseq.csv\n      Name: rat_protein_function_refseq.stat.csv\n      URI: https:/data.glygen.org/ln2releases/data/v-2.1.1/reviewed/rat_protein_function_refseq.stat.csv\n\nFields\n      Name: \"uniprotkb_canonical_ac\"\n     Description: \"\"\n      Unique Values: \"6668\"\n      Name: \"refseq_ac\"\n     Description: \"Accession in the NCBI RefSeq database\"\n      Unique Values: \"6875\"\n      Name: \"xref_key\"\n     Description: \"Source key associated to the  xref_id\"\n      Unique Values: \"2\"\n      Name: \"xref_id\"\n     Description: \"ID of the X-ref\"\n      Unique Values: \"20540\"\n      Name: \"annotation\"\n     Description: \"Function annotation from UniProtKB|RefSeq database\"\n      Unique Values: \"14073\"",
    "downloadurl": "/ln2data/releases/data/v-2.1.1/reviewed/rat_protein_function_refseq.csv"
}
