{
    "bcoid": "GLY_000133",
    "title": "Human Protein Function (NCBI Refseq)",
    "description": "The Human Protein Function (NCBI RefSeq) dataset contains biological function annotation of human [taxid:9606] ...",
    "filename": "human_protein_function_refseq.csv",
    "filetype": "csv",
    "categories": {
        "species": [
            "Homo sapiens"
        ],
        "molecule": [
            "Protein"
        ],
        "tags": [
            "Protein Function"
        ],
        "file_type": [
            "csv"
        ],
        "status": [
            "Reviewed"
        ],
        "scope": [
            "internal"
        ]
    },
    "minitable": {
        "content": [
            [
                "O76074-1...",
                "NP_246273..."
            ],
            [
                "O76074-1...",
                "NP_246273..."
            ]
        ],
        "headers": [
            "uniprotkb_ca...",
            "refseq_ac..."
        ],
        "colwidth": [
            "40%",
            "20%"
        ]
    },
    "sampledata": {
        "type": "table",
        "data": [
            [
                {
                    "type": "string",
                    "label": "uniprotkb_canonical_ac"
                },
                {
                    "type": "string",
                    "label": "refseq_ac"
                },
                {
                    "type": "string",
                    "label": "xref_key"
                },
                {
                    "type": "string",
                    "label": "xref_id"
                },
                {
                    "type": "string",
                    "label": "annotation"
                }
            ],
            [
                "O76074-1",
                "NP_246273",
                "protein_xref_refseq",
                "NP_246273",
                "This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]."
            ],
            [
                "O76074-1",
                "NP_246273",
                "protein_xref_refseq",
                "NP_246273",
                "Cellular Redox Metabolism Is Modulated by the Distinct Localization of Cyclic Nucleotide Phosphodiesterase 5A Isoforms. Publication Status: Online-Only"
            ],
            [
                "O76074-1",
                "NP_246273",
                "protein_xref_pubmed",
                "35955722",
                "Cellular Redox Metabolism Is Modulated by the Distinct Localization of Cyclic Nucleotide Phosphodiesterase 5A Isoforms. Publication Status: Online-Only"
            ],
            [
                "O76074-1",
                "NP_246273",
                "protein_xref_refseq",
                "NP_246273",
                "Identification of a Functional PDE5A Variant at the Chromosome 4q27 Coronary Artery Disease Locus in an Extended Myocardial Infarction Family."
            ],
            [
                "O76074-1",
                "NP_246273",
                "protein_xref_pubmed",
                "34424768",
                "Identification of a Functional PDE5A Variant at the Chromosome 4q27 Coronary Artery Disease Locus in an Extended Myocardial Infarction Family."
            ],
            [
                "O76074-1",
                "NP_246273",
                "protein_xref_refseq",
                "NP_246273",
                "Influencing Factors for Erectile Dysfunction of Young Adults with No Response to PDE5i."
            ],
            [
                "O76074-1",
                "NP_246273",
                "protein_xref_pubmed",
                "34169423",
                "Influencing Factors for Erectile Dysfunction of Young Adults with No Response to PDE5i."
            ],
            [
                "O60232-1",
                "NP_001289953",
                "protein_xref_refseq",
                "NP_001289953",
                "This antigen is recognized by a subset of anti-centromere antibodies from patients with scleroderma and/or Sjogren's syndrome. Subcellular localization has not yet been established. [provided by RefSeq, Jul 2008]."
            ],
            [
                "O60232-1",
                "NP_001289953",
                "protein_xref_refseq",
                "NP_001289953",
                "Our method identified a strong relationship between p27 expression and prostate cancer recurrence."
            ],
            [
                "O60232-1",
                "NP_001289953",
                "protein_xref_pubmed",
                "21292307",
                "Our method identified a strong relationship between p27 expression and prostate cancer recurrence."
            ],
            [
                "O60232-1",
                "NP_001289953",
                "protein_xref_refseq",
                "NP_001289953",
                "The current results showed that p27 expression were associated with glioma grade."
            ],
            [
                "O60232-1",
                "NP_001289953",
                "protein_xref_pubmed",
                "19574837",
                "The current results showed that p27 expression were associated with glioma grade."
            ],
            [
                "Q9NX04-1",
                "NP_001289959",
                "protein_xref_refseq",
                "NP_001289959",
                "C1orf109 promotes malignant phenotype of liver cancer via wnt signaling pathway in a CK2-dependent manner."
            ],
            [
                "Q9NX04-1",
                "NP_001289959",
                "protein_xref_pubmed",
                "36988773",
                "C1orf109 promotes malignant phenotype of liver cancer via wnt signaling pathway in a CK2-dependent manner."
            ],
            [
                "Q9NX04-1",
                "NP_001289959",
                "protein_xref_refseq",
                "NP_001289959",
                "Labeling of heterochronic ribosomes reveals C1ORF109 and SPATA5 control a late step in human ribosome assembly."
            ],
            [
                "Q9NX04-1",
                "NP_001289959",
                "protein_xref_pubmed",
                "35354024",
                "Labeling of heterochronic ribosomes reveals C1ORF109 and SPATA5 control a late step in human ribosome assembly."
            ],
            [
                "Q9NX04-1",
                "NP_001289959",
                "protein_xref_refseq",
                "NP_001289959",
                "Our findings suggest that C1ORF109 may be the downstream target of protein kinase CK2 and involved in the regulation of cancer cell proliferation. Publication Status: Online-Only"
            ],
            [
                "Q9NX04-1",
                "NP_001289959",
                "protein_xref_pubmed",
                "22548824",
                "Our findings suggest that C1ORF109 may be the downstream target of protein kinase CK2 and involved in the regulation of cancer cell proliferation. Publication Status: Online-Only"
            ],
            [
                "Q9Y446-1",
                "NP_001289958",
                "protein_xref_refseq",
                "NP_001289958",
                "This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]."
            ],
            [
                "Q9Y446-1",
                "NP_001289958",
                "protein_xref_refseq",
                "NP_001289958",
                "Disease-related blood-based differential methylation in cystic fibrosis and its representation in lung cancer revealed a regulatory locus in PKP3 in lung epithelial cells."
            ],
            [
                "Q9Y446-1",
                "NP_001289958",
                "protein_xref_pubmed",
                "34415821",
                "Disease-related blood-based differential methylation in cystic fibrosis and its representation in lung cancer revealed a regulatory locus in PKP3 in lung epithelial cells."
            ],
            [
                "Q9Y446-1",
                "NP_001289958",
                "protein_xref_refseq",
                "NP_001289958",
                "Analysis of Multiple Human Tumor Cases Reveals the Carcinogenic Effects of PKP3. Publication Status: Online-Only"
            ],
            [
                "Q9Y446-1",
                "NP_001289958",
                "protein_xref_pubmed",
                "34733461",
                "Analysis of Multiple Human Tumor Cases Reveals the Carcinogenic Effects of PKP3. Publication Status: Online-Only"
            ],
            [
                "Q9Y446-1",
                "NP_001289958",
                "protein_xref_refseq",
                "NP_001289958",
                "Plakophilin 3 and Par3 facilitate desmosomes' association with the apical junctional complex."
            ],
            [
                "Q9Y446-1",
                "NP_001289958",
                "protein_xref_pubmed",
                "34260281",
                "Plakophilin 3 and Par3 facilitate desmosomes' association with the apical junctional complex."
            ],
            [
                "Q9Y446-1",
                "NP_001289958",
                "protein_xref_refseq",
                "NP_001289958",
                "A catenin of the plakophilin-subfamily, Pkp3, responds to canonical-Wnt pathway components and signals."
            ],
            [
                "Q9Y446-1",
                "NP_001289958",
                "protein_xref_pubmed",
                "34058472",
                "A catenin of the plakophilin-subfamily, Pkp3, responds to canonical-Wnt pathway components and signals."
            ],
            [
                "Q9Y446-1",
                "NP_001289958",
                "protein_xref_refseq",
                "NP_001289958",
                "PKP3, whose desmosomal expression and protein interactions are broader than those of PKP1 and -2, is a unique multiprotein binding element in many epithelial desmosomes."
            ],
            [
                "Q9Y446-1",
                "NP_001289958",
                "protein_xref_pubmed",
                "12707304",
                "PKP3, whose desmosomal expression and protein interactions are broader than those of PKP1 and -2, is a unique multiprotein binding element in many epithelial desmosomes."
            ],
            [
                "Q8TBB5-1",
                "NP_001171783",
                "protein_xref_refseq",
                "NP_001171783",
                "KLHDC4 promotes NPC oncogenesis by suppressing cellular apoptosis. Publication Status: Online-Only"
            ],
            [
                "Q8TBB5-1",
                "NP_001171783",
                "protein_xref_pubmed",
                "27030985",
                "KLHDC4 promotes NPC oncogenesis by suppressing cellular apoptosis. Publication Status: Online-Only"
            ],
            [
                "Q9HAT2-1",
                "NP_001186851",
                "protein_xref_refseq",
                "NP_001186851",
                "This gene encodes an enzyme which removes 9-O-acetylation modifications from sialic acids. Mutations in this gene are associated with susceptibility to autoimmune disease 6. Multiple transcript variants encoding different isoforms, found either in the cytosol or in the lysosome, have been found for this gene.[provided by RefSeq, Feb 2011]."
            ],
            [
                "Q9HAT2-1",
                "NP_001186851",
                "protein_xref_refseq",
                "NP_001186851",
                "Analysis of whether SIAE rare variants associated with phenotype of juvenile idiopathic arthritis (JIA) and autoimmunity risk in families with primary antibody deficiencies(PADS); 3 novel variants were found in patients with JIA and in their healthy relatives without autoimmunity; none of PAD patients or their relatives had SIAE defects; results show SIAE rare variants are not causative of autoimmunity as single defects"
            ],
            [
                "Q9HAT2-1",
                "NP_001186851",
                "protein_xref_pubmed",
                "28900629",
                "Analysis of whether SIAE rare variants associated with phenotype of juvenile idiopathic arthritis (JIA) and autoimmunity risk in families with primary antibody deficiencies(PADS); 3 novel variants were found in patients with JIA and in their healthy relatives without autoimmunity; none of PAD patients or their relatives had SIAE defects; results show SIAE rare variants are not causative of autoimmunity as single defects"
            ],
            [
                "Q9HAT2-1",
                "NP_001186851",
                "protein_xref_refseq",
                "NP_001186851",
                "Authors determined whether mutations in the SIAE gene are responsible for RA in a Han Chinese population Publication Status: Online-Only"
            ],
            [
                "Q9HAT2-1",
                "NP_001186851",
                "protein_xref_pubmed",
                "26535733",
                "Authors determined whether mutations in the SIAE gene are responsible for RA in a Han Chinese population Publication Status: Online-Only"
            ],
            [
                "Q9HAT2-1",
                "NP_001186851",
                "protein_xref_refseq",
                "NP_001186851",
                "We found A467V SIAE variants (c.1400C>T, rs7941523) in a heterozygous state in all the patients with anti-PIT-1 antibody syndrome."
            ],
            [
                "Q9HAT2-1",
                "NP_001186851",
                "protein_xref_pubmed",
                "24748456",
                "We found A467V SIAE variants (c.1400C>T, rs7941523) in a heterozygous state in all the patients with anti-PIT-1 antibody syndrome."
            ],
            [
                "Q9HAT2-1",
                "NP_001186851",
                "protein_xref_refseq",
                "NP_001186851",
                "SIAE may be associated with autoimmunity."
            ],
            [
                "Q9HAT2-1",
                "NP_001186851",
                "protein_xref_pubmed",
                "23308225",
                "SIAE may be associated with autoimmunity."
            ],
            [
                "Q15744-1",
                "NP_001796",
                "protein_xref_refseq",
                "NP_001796",
                "The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-delta. The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells. Mutations in this gene have been associated with Specific Granule Deficiency, a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]."
            ],
            [
                "Q15744-1",
                "NP_001796",
                "protein_xref_refseq",
                "NP_001796",
                "Significance of CEBPE Gene Promoter Polymorphism (Rs2239630 G > A) Assessment in Childhood B-cell Acute Lymphoblastic Leukemia."
            ],
            [
                "Q15744-1",
                "NP_001796",
                "protein_xref_pubmed",
                "36897378",
                "Significance of CEBPE Gene Promoter Polymorphism (Rs2239630 G > A) Assessment in Childhood B-cell Acute Lymphoblastic Leukemia."
            ],
            [
                "Q15744-1",
                "NP_001796",
                "protein_xref_refseq",
                "NP_001796",
                "The CEBPE rs2239633 genetic polymorphism on susceptibility to childhood acute lymphoblastic leukemia: an updated meta-analysis. Publication Status: Online-Only"
            ],
            [
                "Q15744-1",
                "NP_001796",
                "protein_xref_pubmed",
                "33397280",
                "The CEBPE rs2239633 genetic polymorphism on susceptibility to childhood acute lymphoblastic leukemia: an updated meta-analysis. Publication Status: Online-Only"
            ],
            [
                "Q15744-1",
                "NP_001796",
                "protein_xref_refseq",
                "NP_001796",
                "Identification and genomic analysis of pedigrees with exceptional longevity identifies candidate rare variants."
            ],
            [
                "Q15744-1",
                "NP_001796",
                "protein_xref_pubmed",
                "32574725",
                "Identification and genomic analysis of pedigrees with exceptional longevity identifies candidate rare variants."
            ],
            [
                "Q15744-1",
                "NP_001796",
                "protein_xref_refseq",
                "NP_001796",
                "Loss of myeloid-specific lamin A/C drives lung metastasis through Gfi-1 and C/EBPepsilon-mediated granulocytic differentiation."
            ],
            [
                "Q15744-1",
                "NP_001796",
                "protein_xref_pubmed",
                "31912614",
                "Loss of myeloid-specific lamin A/C drives lung metastasis through Gfi-1 and C/EBPepsilon-mediated granulocytic differentiation."
            ],
            [
                "Q15744-1",
                "NP_001796",
                "protein_xref_refseq",
                "NP_001796",
                "A single amino acid deletion of either R247 (DeltaR) or S248 (DeltaS) was sufficient for the loss of C/EBP-epsilon transcriptional activity, while an amino acid substitution at S248 to alanine in C/EBP-epsilon (SA) had comparable transcriptional activity with the wild-type C/EBP-epsilon (WT).  An acetylation mimic form of C/EBP-epsilon DeltaRS does not have transcriptional activity. C/EBP-epsilon DeltaRS interacts with..."
            ],
            [
                "Q15744-1",
                "NP_001796",
                "protein_xref_pubmed",
                "31256937",
                "A single amino acid deletion of either R247 (DeltaR) or S248 (DeltaS) was sufficient for the loss of C/EBP-epsilon transcriptional activity, while an amino acid substitution at S248 to alanine in C/EBP-epsilon (SA) had comparable transcriptional activity with the wild-type C/EBP-epsilon (WT).  An acetylation mimic form of C/EBP-epsilon DeltaRS does not have transcriptional activity. C/EBP-epsilon DeltaRS interacts with..."
            ],
            [
                "P47902-1",
                "NP_001795",
                "protein_xref_refseq",
                "NP_001795",
                "This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded DNA-binding protein regulates intestine-specific gene expression and enterocyte differentiation. It has been shown to induce expression of the intestinal alkaline phosphatase gene, and inhibit beta-catenin/T-cell factor transcriptional activity. [provided by RefSeq, Jul 2008]."
            ],
            [
                "P47902-1",
                "NP_001795",
                "protein_xref_refseq",
                "NP_001795",
                "LncRNA FOXD2-AS1 accelerates the progression of cervical cancer via downregulating CDX1."
            ],
            [
                "P47902-1",
                "NP_001795",
                "protein_xref_pubmed",
                "31841177",
                "LncRNA FOXD2-AS1 accelerates the progression of cervical cancer via downregulating CDX1."
            ],
            [
                "P47902-1",
                "NP_001795",
                "protein_xref_refseq",
                "NP_001795",
                "This study shows that CDX1 contributes to the tumorigenesis and progression of gastric cancer and suggests the potential of targeting CDX1 to treat this malignancy."
            ],
            [
                "P47902-1",
                "NP_001795",
                "protein_xref_pubmed",
                "31416838",
                "This study shows that CDX1 contributes to the tumorigenesis and progression of gastric cancer and suggests the potential of targeting CDX1 to treat this malignancy."
            ],
            [
                "P47902-1",
                "NP_001795",
                "protein_xref_refseq",
                "NP_001795",
                "Low CDX1 expression is correlated with Gastric Adenocarcinoma."
            ],
            [
                "P47902-1",
                "NP_001795",
                "protein_xref_pubmed",
                "30685841",
                "Low CDX1 expression is correlated with Gastric Adenocarcinoma."
            ],
            [
                "P47902-1",
                "NP_001795",
                "protein_xref_refseq",
                "NP_001795",
                "These data highlight a possible role of CDX1 in altering the N-glycosylation of colorectal cancer cells, which is a hallmark of tumor development. Publication Status: Online-Only"
            ],
            [
                "P47902-1",
                "NP_001795",
                "protein_xref_pubmed",
                "30909444",
                "These data highlight a possible role of CDX1 in altering the N-glycosylation of colorectal cancer cells, which is a hallmark of tumor development. Publication Status: Online-Only"
            ],
            [
                "P47902-1",
                "NP_001795",
                "protein_xref_refseq",
                "NP_001795",
                "High CDX1 expression is associated with esophageal adenocarcinoma. Publication Status: Online-Only"
            ],
            [
                "P47902-1",
                "NP_001795",
                "protein_xref_pubmed",
                "30486614",
                "High CDX1 expression is associated with esophageal adenocarcinoma. Publication Status: Online-Only"
            ],
            [
                "P47902-1",
                "NP_001795",
                "protein_xref_refseq",
                "NP_001795",
                "These data show that Cdx1 exhibits a complex pattern during colorectal cancer progression, a high level of expression in polyps, and in one-third of the specimens, suggest that this gene may be a factor in the process toward malignant transformation"
            ],
            [
                "P47902-1",
                "NP_001795",
                "protein_xref_pubmed",
                "12970739",
                "These data show that Cdx1 exhibits a complex pattern during colorectal cancer progression, a high level of expression in polyps, and in one-third of the specimens, suggest that this gene may be a factor in the process toward malignant transformation"
            ],
            [
                "P47902-1",
                "NP_001795",
                "protein_xref_refseq",
                "NP_001795",
                "CDX1 is downregulated after promoter methylation in colorectal tumor cell lines"
            ],
            [
                "P47902-1",
                "NP_001795",
                "protein_xref_pubmed",
                "12124393",
                "CDX1 is downregulated after promoter methylation in colorectal tumor cell lines"
            ],
            [
                "P47902-1",
                "NP_001795",
                "protein_xref_refseq",
                "NP_001795",
                "Increased CDX1 mRNA expression is associated with chronic atrophic gastritis"
            ],
            [
                "P47902-1",
                "NP_001795",
                "protein_xref_pubmed",
                "11846061",
                "Increased CDX1 mRNA expression is associated with chronic atrophic gastritis"
            ],
            [
                "P31358-1",
                "NP_001794",
                "protein_xref_refseq",
                "NP_001794",
                "High expression of CD52 in adipocytes: a potential therapeutic target for obesity with type 2 diabetes."
            ],
            [
                "P31358-1",
                "NP_001794",
                "protein_xref_pubmed",
                "33705353",
                "High expression of CD52 in adipocytes: a potential therapeutic target for obesity with type 2 diabetes."
            ],
            [
                "P31358-1",
                "NP_001794",
                "protein_xref_refseq",
                "NP_001794",
                "CD52 Is Elevated on B cells of SLE Patients and Regulates B Cell Function. Publication Status: Online-Only"
            ],
            [
                "P31358-1",
                "NP_001794",
                "protein_xref_pubmed",
                "33658999",
                "CD52 Is Elevated on B cells of SLE Patients and Regulates B Cell Function. Publication Status: Online-Only"
            ],
            [
                "P31358-1",
                "NP_001794",
                "protein_xref_refseq",
                "NP_001794",
                "Mutations in PIGA cause a CD52-/GPI-anchor-deficient phenotype complicating alemtuzumab treatment in T-cell prolymphocytic leukemia."
            ],
            [
                "P31358-1",
                "NP_001794",
                "protein_xref_pubmed",
                "32875608",
                "Mutations in PIGA cause a CD52-/GPI-anchor-deficient phenotype complicating alemtuzumab treatment in T-cell prolymphocytic leukemia."
            ],
            [
                "P31358-1",
                "NP_001794",
                "protein_xref_refseq",
                "NP_001794",
                "Soluble CD52 exerts a concerted immunosuppressive effect by first sequestering HMGB1 to nullify its proinflammatory Box B, followed by binding to the inhibitory Siglec-10 receptor, triggering recruitment of SHP1 to the intracellular immunoreceptor tyrosine-based inhibitory motif of Siglec-10 and its interaction with the TCR. Erratum:[Proc Natl Acad Sci U S A. 2019 Apr 9;116(15):7592-7593. PMID: 30936310]"
            ],
            [
                "P31358-1",
                "NP_001794",
                "protein_xref_pubmed",
                "29997173",
                "Soluble CD52 exerts a concerted immunosuppressive effect by first sequestering HMGB1 to nullify its proinflammatory Box B, followed by binding to the inhibitory Siglec-10 receptor, triggering recruitment of SHP1 to the intracellular immunoreceptor tyrosine-based inhibitory motif of Siglec-10 and its interaction with the TCR. Erratum:[Proc Natl Acad Sci U S A. 2019 Apr 9;116(15):7592-7593. PMID: 30936310]"
            ],
            [
                "P31358-1",
                "NP_001794",
                "protein_xref_refseq",
                "NP_001794",
                "This polyclonal mutational landscape in the PIGA gene was also found in CD52(-) T cells present."
            ],
            [
                "P31358-1",
                "NP_001794",
                "protein_xref_pubmed",
                "29427418",
                "This polyclonal mutational landscape in the PIGA gene was also found in CD52(-) T cells present."
            ],
            [
                "Q01850-1",
                "NP_001793",
                "protein_xref_refseq",
                "NP_001793",
                "MicroRNA 452 regulates ASB8, NOL8, and CDR2 expression in colorectal cancer cells."
            ],
            [
                "Q01850-1",
                "NP_001793",
                "protein_xref_pubmed",
                "33398662",
                "MicroRNA 452 regulates ASB8, NOL8, and CDR2 expression in colorectal cancer cells."
            ],
            [
                "Q01850-1",
                "NP_001793",
                "protein_xref_refseq",
                "NP_001793",
                "Our data pinpointed the enrichment of acquired immune response, particularly high density of CD8+ lymphocytes, and high-level expression of CDR-related antigens in anti-Yo paraneoplastic cerebellar degeneration ovarian tumours."
            ],
            [
                "Q01850-1",
                "NP_001793",
                "protein_xref_pubmed",
                "29899393",
                "Our data pinpointed the enrichment of acquired immune response, particularly high density of CD8+ lymphocytes, and high-level expression of CDR-related antigens in anti-Yo paraneoplastic cerebellar degeneration ovarian tumours."
            ],
            [
                "P55273-1",
                "NP_001791",
                "protein_xref_refseq",
                "NP_001791",
                "The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]."
            ],
            [
                "P55273-1",
                "NP_001791",
                "protein_xref_refseq",
                "NP_001791",
                "Identification of <i>Cdk8</i> and <i>Cdkn2d</i> as New Prame-Target Genes in 2C-like Embryonic Stem Cells. Publication Status: Online-Only"
            ]
        ]
    },
    "readme": "Name\n   - Human Protein Function (NCBI Refseq)\n\nVersion\n   - v-2.1.1\n\nCreated on\n  - 2019-03-16T15:35:15.248632\n\nModified on\n   - 2022-09-26T08:56:48.489276\n\nCreated by\n   - Jeet Vora [jeetvora@gwu.edu], Robel Kahsay [rykahsay@gwu.edu], Karina Martinez [karinamartinez@gwu.edu], Jingyue Wu [jingyue.wu@email.gwu.edu]\n\nAuthors\n   - Maria Martin [martin@ebi.ac.uk], Preethi Vasudev [pvasudev@ebi.ac.uk]\n\nChecksum\n   - \n\nUsability Domain\n   - The Human Protein Function (NCBI RefSeq) dataset contains biological function annotation of human [taxid:9606] genes from GeneRIF section in the NCBI RefSeq database. The dataset is downloaded from NCBI RefSeq Release 96, September 9, 2019. If you use this dataset please provide proper attribution to NCBI RefSeq and GlyGen. \n\nDescription Domain\n   Keywords\n   - protein function\n   - NCBI RefSeq\n   - geneRIF\n   - PMID\n\n   Pipeline Steps\n   - Step-1: The script parses the NCBI RefSeq gpff files to extract the geneRIFs that contain protein function. The script also maps RefSeq accession to the UniProtKB Canonical accessions. \n\nExecution Domain\n   Scripts   - https://github.com/glygener/glygen-backend-integration/blob/master/dataset-maker/make-protein-dataset.py\n\n\n   Software Prerequisites\n      Name: Python\n      Version: 2.7.5\n      URI: https://www.python.org/download/releases/2.7.5/\n\nI/O Domain\n   Input Subdomain\n      Name: human_protein_xref_refseq.csv\n      URI: https:/data.glygen.org/ln2releases/data/v-2.1.1/reviewed/human_protein_xref_refseq.csv\n      Name: refseq_protein_all_9606.gpff\n      URI: /data/shared/glyds/downloads/ncbi/refseq/2023_04/refseq_protein_all_9606.gpff\n   Output Subdomain\n      Name: human_protein_function_refseq.csv\n      URI: https:/data.glygen.org/ln2releases/data/v-2.1.1/reviewed/human_protein_function_refseq.csv\n      Name: human_protein_function_refseq.stat.csv\n      URI: https:/data.glygen.org/ln2releases/data/v-2.1.1/reviewed/human_protein_function_refseq.stat.csv\n\nFields\n      Name: \"uniprotkb_canonical_ac\"\n     Description: \"\"\n      Unique Values: \"16901\"\n      Name: \"refseq_ac\"\n     Description: \"Accession in the NCBI RefSeq database\"\n      Unique Values: \"18992\"\n      Name: \"xref_key\"\n     Description: \"Source key associated to the  xref_id\"\n      Unique Values: \"2\"\n      Name: \"xref_id\"\n     Description: \"ID of the X-ref\"\n      Unique Values: \"77434\"\n      Name: \"annotation\"\n     Description: \"Function annotation from UniProtKB|RefSeq database\"\n      Unique Values: \"70219\"",
    "downloadurl": "/ln2data/releases/data/v-2.1.1/reviewed/human_protein_function_refseq.csv"
}
