{ "batchid": 1, "recordid": "P04637-1", "recordtype": "protein", "sections": { "snv": [ { "evidence": [ { "id": "P04637", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04637" } ], "glycoeffect": [], "start_pos": 109, "end_pos": 109, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "F", "sequence_mut": "C", "comment": "Somatic mutation passed 2 out of 6 filters: num. of cancers (6); DB annot. (1).", "chr_id": "17", "chr_pos": "7676043", "ref_nt": "T", "alt_nt": "G", "minor_allelic_frequency": "", "disease": [ { "disease_id": "DOID:2394", "recommended_name": { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovarian cancer", "description": "A female reproductive organ cancer that is located_in the ovary." }, "synonyms": [ { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "malignant Ovarian tumor", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "malignant tumour of ovary", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovarian neoplasm", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovary neoplasm", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "primary ovarian cancer", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "tumor of the Ovary", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to, 1", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to, 1", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "OVCAS1", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer", "description": "A primary or metastatic malignant neoplasm involving the ovary. Most primary malignant ovarian neoplasms are either carcinomas (serous, mucinous, or endometrioid adenocarcinomas) or malignant germ cell tumors. Metastatic malignant neoplasms to the ovary include carcinomas, lymphomas, and melanomas." }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant neoplasm of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovary neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "primary ovarian cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian malignant tumor", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumour of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumor of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "cancer of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer, epithelial", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumor of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "cancer of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer, somatic", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovary cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian tumor", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "tumor of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant neoplasm of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovary neoplasm", "description": "" }, { "id": "MIM:167000", "resource": "MIM", "url": "https://www.omim.org/entry/167000", "name": "Ovarian cancer", "description": "Ovarian cancer" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectal adenocarcinoma", "description": "The most common type of colorectal carcinoma. It is characterized by the presence of malignant glandular epithelial cells invading through the muscularis mucosa into the submucosa. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma." }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of the large intestine", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "large bowel adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of large intestine", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectal adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectum adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of the large bowel", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "large intestine adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectal (colon or rectal) adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectal neoplasm", "description": "A benign or malignant neoplasm that affects the colon or rectum. Representative examples of benign neoplasms include lipoma and leiomyoma. Representative examples of malignant neoplasms include carcinoma, lymphoma, and sarcoma. Colorectal adenomas always exhibit epithelial dysplasia and are considered premalignant neoplasms." }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectal tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large bowel neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectum tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large intestinal neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectum neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large bowel tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectal neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "tumor of the large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "tumor of colorectum", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectum neoplasm (disease)", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "tumor of large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large intestine tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large intestine neoplasm", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] }, { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostate cancer", "description": "A primary or metastatic malignant tumor involving the prostate gland. The vast majority are carcinomas." }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant tumor of prostate", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant neoplasm of prostate", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant neoplasm of prostate gland", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant prostate tumor", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant neoplasm of the prostate", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostate neoplasm", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostate gland cancer", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant prostate neoplasm", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostatic cancer", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant tumor of the prostate", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostatic neoplasm", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant prostate gland neoplasm", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "cancer of prostate gland", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "NGP - new growth of prostate", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] }, { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "alveolar cell carcinoma", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "Nonsmall cell lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] }, { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease 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"Breast cancer", "description": "Breast cancer" } ] }, { "disease_id": "DOID:1793", "recommended_name": { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic cancer", "description": "An endocrine gland cancer located_in the pancreas." }, "synonyms": [ { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreas neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic tumor", "description": "" } ] }, { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] }, { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "Thyroid gland neoplasm", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant tumour of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid neoplasm", "description": "" } ] }, { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. 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"description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "alveolar cell carcinoma", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "Nonsmall cell lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] }, { "disease_id": "DOID:4362", "recommended_name": { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "cervical cancer", "description": "A female reproductive organ cancer that is located_in the cervix." }, "synonyms": [ { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "cervical neoplasm", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "cervix cancer", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "cervix uteri cancer", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "neoplasm of uterine cervix", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "tumor of the Cervix Uteri", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "uterine cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervical cancer", "description": "A primary or metastatic malignant neoplasm involving the cervix." }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervix uteri cancer", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix uteri tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant uterine cervix tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of the uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervix cancer", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "tumor of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of the cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervical tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "uterine cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant uterine cervix neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervical cancer, somatic", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of the uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of the cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": 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"http://disease-ontology.org/term/DOID:8618", "name": "oral cavity cancer", "description": "A gastrointestinal system cancer that is located_in the oral cavity." }, "synonyms": [ { "id": "DOID:8618", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8618", "name": "malignant neoplasm of floor of mouth", "description": "" } ] }, { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostate cancer", "description": "A primary or metastatic malignant tumor involving the prostate gland. The vast majority are carcinomas." }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant tumor of prostate", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant neoplasm of prostate", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant neoplasm of prostate gland", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant prostate tumor", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant neoplasm of the prostate", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostate neoplasm", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostate gland cancer", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant prostate neoplasm", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostatic cancer", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant tumor of the prostate", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostatic neoplasm", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant prostate gland neoplasm", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "cancer of prostate gland", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "NGP - new growth of prostate", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectal adenocarcinoma", "description": "The most common type of colorectal carcinoma. It is characterized by the presence of malignant glandular epithelial cells invading through the muscularis mucosa into the submucosa. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma." }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of the large intestine", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "large bowel adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of large intestine", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectal adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectum adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of the large bowel", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "large intestine adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectal (colon or rectal) adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectal neoplasm", "description": "A benign or malignant neoplasm that affects the colon or rectum. Representative examples of benign neoplasms include lipoma and leiomyoma. Representative examples of malignant neoplasms include carcinoma, lymphoma, and sarcoma. Colorectal adenomas always exhibit epithelial dysplasia and are considered premalignant neoplasms." }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectal tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large bowel neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectum tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large intestinal neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectum neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large bowel tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectal neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "tumor of the large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "tumor of colorectum", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectum neoplasm (disease)", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "tumor of large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large intestine tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large intestine neoplasm", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] }, { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ] }, { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] }, { "disease_id": "DOID:2394", "recommended_name": { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovarian cancer", "description": "A female reproductive organ cancer that is located_in the ovary." }, "synonyms": [ { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "malignant Ovarian tumor", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "malignant tumour of ovary", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovarian neoplasm", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovary neoplasm", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "primary ovarian cancer", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "tumor of the Ovary", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to, 1", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to, 1", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "OVCAS1", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer", "description": "A primary or metastatic malignant neoplasm involving the ovary. Most primary malignant ovarian neoplasms are either carcinomas (serous, mucinous, or endometrioid adenocarcinomas) or malignant germ cell tumors. Metastatic malignant neoplasms to the ovary include carcinomas, lymphomas, and melanomas." }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant neoplasm of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovary neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "primary ovarian cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian malignant tumor", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumour of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumor of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "cancer of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer, epithelial", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumor of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "cancer of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer, somatic", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovary cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian tumor", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "tumor of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant neoplasm of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovary neoplasm", "description": "" }, { "id": "MIM:167000", "resource": "MIM", "url": "https://www.omim.org/entry/167000", "name": "Ovarian cancer", "description": "Ovarian cancer" } ] }, { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Escc, susceptibility to", "description": "" }, { 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"http://disease-ontology.org/term/DOID:2531", "name": "hematopoietic and lymphoid system tumor", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematopoietic cancer", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematopoietic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematopoietic tumors", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "malignant hematopoietic neoplasm", "description": "" } ] }, { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer 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"DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] }, { "disease_id": "DOID:4606", "recommended_name": { "id": "DOID:4606", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4606", "name": "bile duct cancer", "description": "A biliary tract cancer that is located_in the bile duct." }, "synonyms": [ { "id": "DOID:4606", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4606", "name": "Ca extrahepatic bile ducts", "description": "" }, { "id": "DOID:4606", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4606", "name": "bile duct tumor", "description": "" }, { "id": "DOID:4606", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4606", "name": "malignant neoplasm of the extrahepatic bile duct", "description": "" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { 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"0", "frequency": "0.0", "sequence_org": "M", "sequence_mut": "T", "comment": "Somatic mutation passed 2 out of 6 filters: num. of cancers (6); n-glyco-sequon-gain (NKM->NKT).", "chr_id": "17", "chr_pos": "7675214", "ref_nt": "T", "alt_nt": "C", "minor_allelic_frequency": "", "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": 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"Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary liver cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "resectable malignant neoplasm of the liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, not specified as primary or secondary", "description": "" } ] }, { "disease_id": "DOID:8618", "recommended_name": { "id": "DOID:8618", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8618", "name": "oral cavity cancer", "description": "A gastrointestinal system cancer that is located_in the oral cavity." }, "synonyms": [ { "id": "DOID:8618", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8618", "name": "malignant neoplasm of floor of mouth", "description": "" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectal adenocarcinoma", "description": "The most common type of colorectal carcinoma. It is characterized by the presence of malignant glandular epithelial cells invading through the muscularis mucosa into the submucosa. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma." }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of the large intestine", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "large bowel adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of large intestine", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectal adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectum adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of the large bowel", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "large intestine adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectal (colon or rectal) adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectal neoplasm", "description": "A benign or malignant neoplasm that affects the colon or rectum. Representative examples of benign neoplasms include lipoma and leiomyoma. Representative examples of malignant neoplasms include carcinoma, lymphoma, and sarcoma. Colorectal adenomas always exhibit epithelial dysplasia and are considered premalignant neoplasms." }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectal tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large bowel neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectum tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large intestinal neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectum neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large bowel tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectal neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "tumor of the large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "tumor of colorectum", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectum neoplasm (disease)", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "tumor of large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large intestine tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large intestine neoplasm", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] }, { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "Thyroid gland neoplasm", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant tumour of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid neoplasm", "description": "" } ] }, { "disease_id": "DOID:2531", "recommended_name": { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematologic cancer", "description": "An organ system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes." }, "synonyms": [ { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "Hematologic malignancy", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "Hematologic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "Hematological tumors", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "blood cancer", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematopoietic and lymphoid system tumor", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematopoietic cancer", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematopoietic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematopoietic tumors", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "malignant hematopoietic neoplasm", "description": "" } ] }, { "disease_id": "DOID:3012", "recommended_name": { "id": "DOID:3012", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3012", "name": "Li-Fraumeni syndrome", "description": "A syndrome characterized by autosomal dominant inheritance of increased risk of developing several types of cancer, including breast cancer, osteosarcomata and soft tissue sarcomata." }, "synonyms": [ { "id": "DOID:3012", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3012", "name": "SBLA syndrome", "description": "" }, { "id": "DOID:3012", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3012", "name": "sarcoma, breast, leukaemia and adrenal gland syndrome", "description": "" }, { "id": "DOID:3012", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3012", "name": "Li-Fraumeni Familiar cancer Susceptibility syndrome", "description": "" }, { "id": "MONDO:0007903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007903", "name": "Li-Fraumeni syndrome 1", "description": "Any Li-Fraumeni syndrome in which the cause of the disease is a mutation in the TP53 gene." }, { "id": "MONDO:0007903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007903", "name": "Li-Fraumeni syndrome 3", "description": "" }, { "id": "MONDO:0007903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007903", "name": "Li-Fraumeni-like syndrome", "description": "" }, { "id": "MONDO:0007903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007903", "name": "LFS1", "description": "" }, { "id": "MONDO:0007903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007903", "name": "Li-Fraumeni syndrome 1", "description": "" }, { "id": "MONDO:0007903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007903", "name": "Li-Fraumeni syndrome", "description": "" }, { "id": "MONDO:0007903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007903", "name": "Sbla syndrome", "description": "" }, { "id": "MONDO:0007903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007903", "name": "Li-Fraumeni syndrome caused by mutation in TP53", "description": "" }, { "id": "MONDO:0007903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007903", "name": "sarcoma family syndrome of 51 and Fraumeni", "description": "" }, { "id": "MONDO:0007903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007903", "name": "LFS", "description": "" }, { "id": "MONDO:0007903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007903", "name": "Li-Fraumeni syndrome type 1", "description": "" }, { "id": "MONDO:0007903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007903", "name": "LFS3", "description": "" }, { "id": "MONDO:0007903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007903", "name": "TP53 Li-Fraumeni syndrome", "description": "" }, { "id": "MIM:151623", "resource": "MIM", "url": "https://www.omim.org/entry/151623", "name": "Li-Fraumeni syndrome", "description": "Li-Fraumeni syndrome" } ] }, { "disease_id": "DOID:0111503", "recommended_name": { "id": "DOID:0111503", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111503", "name": "Li-Fraumeni syndrome 1", "description": "A Li-Fraumeni syndrome that has_material_basis_in heterozygous mutation in TP53 on chromosome 17p13.1." }, "synonyms": [ { "id": "DOID:0111503", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111503", "name": "LFS1", "description": "" }, { "id": "MONDO:0007903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007903", "name": "Li-Fraumeni syndrome 1", "description": "Any Li-Fraumeni syndrome in which the cause of the disease is a mutation in the TP53 gene." }, { "id": "MONDO:0007903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007903", "name": "Li-Fraumeni syndrome 3", "description": "" }, { "id": "MONDO:0007903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007903", "name": "Li-Fraumeni-like syndrome", "description": "" }, { "id": "MONDO:0007903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007903", "name": "LFS1", "description": "" }, { "id": "MONDO:0007903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007903", "name": "Li-Fraumeni syndrome 1", "description": "" }, { "id": "MONDO:0007903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007903", "name": "Li-Fraumeni syndrome", "description": "" }, { "id": "MONDO:0007903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007903", "name": "Sbla syndrome", "description": "" }, { "id": "MONDO:0007903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007903", "name": "Li-Fraumeni syndrome caused by mutation in TP53", "description": "" }, { "id": "MONDO:0007903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007903", "name": "sarcoma family syndrome of 51 and Fraumeni", "description": "" }, { "id": "MONDO:0007903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007903", "name": "LFS", "description": "" }, { "id": "MONDO:0007903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007903", "name": "Li-Fraumeni syndrome type 1", "description": "" }, { "id": "MONDO:0007903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007903", "name": "LFS3", "description": "" }, { "id": "MONDO:0007903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007903", "name": "TP53 Li-Fraumeni syndrome", "description": "" }, { "id": "MONDO:0007903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007903", "name": "Li-Fraumeni syndrome 1", "description": "Any Li-Fraumeni syndrome in which the cause of the disease is a mutation in the TP53 gene." }, { "id": "MONDO:0007903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007903", "name": "Li-Fraumeni syndrome 3", "description": "" }, { "id": "MONDO:0007903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007903", "name": "Li-Fraumeni-like syndrome", "description": "" }, { "id": "MONDO:0007903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007903", "name": "LFS1", "description": "" }, { "id": "MONDO:0007903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007903", "name": "Li-Fraumeni syndrome 1", "description": "" }, { "id": "MONDO:0007903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007903", "name": "Li-Fraumeni syndrome", "description": "" }, { "id": "MONDO:0007903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007903", "name": "Sbla syndrome", "description": "" }, { "id": "MONDO:0007903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007903", "name": "Li-Fraumeni syndrome caused by mutation in TP53", "description": "" }, { "id": "MONDO:0007903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007903", "name": "sarcoma family syndrome of 51 and Fraumeni", "description": "" }, { "id": "MONDO:0007903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007903", "name": "LFS", "description": "" }, { "id": "MONDO:0007903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007903", "name": "Li-Fraumeni syndrome type 1", "description": "" }, { "id": "MONDO:0007903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007903", "name": "LFS3", "description": "" }, { "id": "MONDO:0007903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007903", "name": "TP53 Li-Fraumeni syndrome", "description": "" }, { "id": "MIM:151623", "resource": "MIM", "url": "https://www.omim.org/entry/151623", "name": "Li-Fraumeni syndrome", "description": "Li-Fraumeni syndrome" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease", "ebi" ] }, { "evidence": [ { "id": "P04637", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04637" } ], "glycoeffect": [], "start_pos": 134, "end_pos": 134, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "F", "sequence_mut": "V", "comment": "Somatic mutation passed 2 out of 6 filters: num. of cancers (11); DB annot. 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The vast majority of cases are carcinomas arising from the breast parenchyma or the nipple. Malignant breast neoplasms occur more frequently in females than in males." }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant tumor of the breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant tumor of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant neoplasm of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "cancer of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant breast tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant neoplasm of the breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant breast neoplasm", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary neoplasm", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast cancer", "description": "A primary or metastatic malignant neoplasm involving the breast. The vast majority of cases are carcinomas arising from the breast parenchyma or the nipple. Malignant breast neoplasms occur more frequently in females than in males." }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant tumor of the breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant tumor of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant neoplasm of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "cancer of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant breast tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant neoplasm of the breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant breast neoplasm", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary neoplasm", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary cancer", "description": "" }, { "id": "MONDO:0010804", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010804", "name": "obsolete BRCATA", "description": "" }, { "id": "MONDO:0010804", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010804", "name": "moved to 114480", "description": "" }, { "id": "MONDO:0010804", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010804", "name": "BRCATA", "description": "" }, { "id": "MONDO:0010804", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010804", "name": "breast cancer, 11-22 translocation-associated", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] }, { "disease_id": "DOID:8618", "recommended_name": { "id": "DOID:8618", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8618", "name": "oral cavity cancer", "description": "A gastrointestinal system cancer that is located_in the oral cavity." }, "synonyms": [ { "id": "DOID:8618", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8618", "name": "malignant neoplasm of floor of mouth", "description": "" } ] }, { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] }, { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ] }, { "disease_id": "DOID:1793", "recommended_name": { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic cancer", "description": "An endocrine gland cancer located_in the pancreas." }, "synonyms": [ { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreas neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic tumor", "description": "" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectal adenocarcinoma", "description": "The most common type of colorectal carcinoma. It is characterized by the presence of malignant glandular epithelial cells invading through the muscularis mucosa into the submucosa. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma." }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of the large intestine", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "large bowel adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of large intestine", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectal adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectum adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of the large bowel", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "large intestine adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectal (colon or rectal) adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectal neoplasm", "description": "A benign or malignant neoplasm that affects the colon or rectum. Representative examples of benign neoplasms include lipoma and leiomyoma. Representative examples of malignant neoplasms include carcinoma, lymphoma, and sarcoma. Colorectal adenomas always exhibit epithelial dysplasia and are considered premalignant neoplasms." }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectal tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large bowel neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectum tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large intestinal neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectum neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large bowel tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectal neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "tumor of the large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "tumor of colorectum", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectum neoplasm (disease)", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "tumor of large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large intestine tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large intestine neoplasm", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] }, { "disease_id": "DOID:2394", "recommended_name": { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovarian cancer", "description": "A female reproductive organ cancer that is located_in the ovary." }, "synonyms": [ { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "malignant Ovarian tumor", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "malignant tumour of ovary", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovarian neoplasm", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovary neoplasm", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "primary ovarian cancer", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "tumor of the Ovary", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to, 1", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to, 1", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "OVCAS1", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer", "description": "A primary or metastatic malignant neoplasm involving the ovary. Most primary malignant ovarian neoplasms are either carcinomas (serous, mucinous, or endometrioid adenocarcinomas) or malignant germ cell tumors. Metastatic malignant neoplasms to the ovary include carcinomas, lymphomas, and melanomas." }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant neoplasm of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovary neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "primary ovarian cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian malignant tumor", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumour of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumor of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "cancer of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer, epithelial", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumor of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "cancer of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer, somatic", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovary cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian tumor", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "tumor of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant neoplasm of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovary neoplasm", "description": "" }, { "id": "MIM:167000", "resource": "MIM", "url": "https://www.omim.org/entry/167000", "name": "Ovarian cancer", "description": "Ovarian cancer" } ] }, { "disease_id": "DOID:1319", "recommended_name": { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "brain cancer", "description": "A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain." }, "synonyms": [ { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "BT - Brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "adult brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "adult malignant brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm, adult", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of Brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of adult brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "primary malignant neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "tumor of the Brain", "description": "" } ] }, { "disease_id": "DOID:2531", "recommended_name": { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematologic cancer", "description": "An organ system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes." }, "synonyms": [ { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "Hematologic malignancy", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "Hematologic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "Hematological tumors", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "blood cancer", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematopoietic and lymphoid system tumor", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematopoietic cancer", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematopoietic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematopoietic tumors", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "malignant hematopoietic neoplasm", "description": "" } ] }, { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "alveolar cell carcinoma", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "Nonsmall cell lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] }, { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostate cancer", "description": "A primary or metastatic malignant tumor involving the prostate gland. The vast majority are carcinomas." }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant tumor of prostate", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant neoplasm of prostate", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant neoplasm of prostate gland", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant prostate tumor", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant neoplasm of the prostate", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostate neoplasm", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostate gland cancer", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant prostate neoplasm", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostatic cancer", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant tumor of the prostate", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostatic neoplasm", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant prostate gland neoplasm", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "cancer of prostate gland", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "NGP - new growth of prostate", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, 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"prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "P04637", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04637" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 148, "end_pos": 148, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "D", "sequence_mut": "N", "comment": "Somatic mutation passed 2 out of 6 filters: num. of cancers (7); n-glyco-sequon-gain (DST->NST).", "chr_id": "17", "chr_pos": "7675170", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "Thyroid gland neoplasm", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant tumour of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid neoplasm", "description": "" } ] }, { "disease_id": "DOID:2531", "recommended_name": { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematologic cancer", "description": "An organ system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes." }, "synonyms": [ { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "Hematologic malignancy", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "Hematologic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "Hematological tumors", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "blood cancer", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematopoietic and lymphoid system tumor", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematopoietic cancer", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematopoietic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematopoietic tumors", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "malignant hematopoietic neoplasm", "description": "" } ] }, { "disease_id": "DOID:8618", "recommended_name": { "id": "DOID:8618", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8618", "name": "oral cavity cancer", "description": "A gastrointestinal system cancer that is located_in the oral cavity." }, "synonyms": [ { "id": "DOID:8618", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8618", "name": "malignant neoplasm of floor of mouth", "description": "" } ] }, { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] }, { "disease_id": "DOID:1245", "recommended_name": { "id": "DOID:1245", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1245", "name": "vulva cancer", "description": "A female reproductive organ cancer that is located_in the vulva." }, "synonyms": [ { "id": "DOID:1245", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1245", "name": "Ca vulva", "description": "" }, { "id": "DOID:1245", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1245", "name": "Vulvar tumor", "description": "" }, { "id": "DOID:1245", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1245", "name": "malignant Vulvar tumor", "description": "" }, { "id": "DOID:1245", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1245", "name": "malignant neoplasm of vulva", "description": "" }, { "id": "DOID:1245", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1245", "name": "malignant tumor of vulva", "description": "" }, { "id": "DOID:1245", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1245", "name": "neoplasm of vulva", "description": "" }, { "id": "DOID:1245", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1245", "name": "vulval cancer", "description": "" }, { "id": "DOID:1245", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1245", "name": "vulval neoplasm", "description": "" }, { "id": "DOID:1245", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1245", "name": "vulvar neoplasm", "description": "" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectal adenocarcinoma", "description": "The most common type of colorectal carcinoma. It is characterized by the presence of malignant glandular epithelial cells invading through the muscularis mucosa into the submucosa. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma." }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of the large intestine", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "large bowel adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of large intestine", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectal adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectum adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of the large bowel", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "large intestine adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectal (colon or rectal) adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectal neoplasm", "description": "A benign or malignant neoplasm that affects the colon or rectum. Representative examples of benign neoplasms include lipoma and leiomyoma. Representative examples of malignant neoplasms include carcinoma, lymphoma, and sarcoma. Colorectal adenomas always exhibit epithelial dysplasia and are considered premalignant neoplasms." }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectal tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large bowel neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectum tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large intestinal neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectum neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large bowel tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectal neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "tumor of the large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "tumor of colorectum", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectum neoplasm (disease)", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "tumor of large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large intestine tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large intestine neoplasm", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "P04637", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04637" }, { "id": "rs1555526214", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1555526214" }, { "id": "rs1555526214", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1555526214" }, { "id": "14962108", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/14962108" }, { "id": "15611505", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/15611505" }, { "id": "20668451", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/20668451" }, { "id": "8630516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8630516" }, { "id": "9622088", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9622088" }, { "id": "rs1064793929", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1064793929" }, { "id": "rs1064793929", "database": "NCI-TCGA", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1064793929" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 149, "end_pos": 149, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "S", "sequence_mut": "F", "comment": "Somatic mutation passed 2 out of 6 filters: num. of cancers (4); o-glyco-site-loss (S->F).", "chr_id": "17", "chr_pos": "7675166", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "disease": [ { "disease_id": "DOID:2394", "recommended_name": { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovarian cancer", "description": "A female reproductive organ cancer that is located_in the ovary." }, "synonyms": [ { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "malignant Ovarian tumor", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "malignant tumour of ovary", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovarian neoplasm", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovary neoplasm", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "primary ovarian cancer", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "tumor of the Ovary", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to, 1", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to, 1", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "OVCAS1", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer", "description": "A primary or metastatic malignant neoplasm involving the ovary. Most primary malignant ovarian neoplasms are either carcinomas (serous, mucinous, or endometrioid adenocarcinomas) or malignant germ cell tumors. Metastatic malignant neoplasms to the ovary include carcinomas, lymphomas, and melanomas." }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant neoplasm of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovary neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "primary ovarian cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian malignant tumor", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumour of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumor of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "cancer of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer, epithelial", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumor of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "cancer of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer, somatic", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovary cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian tumor", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "tumor of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant neoplasm of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovary neoplasm", "description": "" }, { "id": "MIM:167000", "resource": "MIM", "url": "https://www.omim.org/entry/167000", "name": "Ovarian cancer", "description": "Ovarian cancer" } ] }, { "disease_id": "DOID:8618", "recommended_name": { "id": "DOID:8618", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8618", "name": "oral cavity cancer", "description": "A gastrointestinal system cancer that is located_in the oral cavity." }, "synonyms": [ { "id": "DOID:8618", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8618", "name": "malignant neoplasm of floor of mouth", "description": "" } ] }, { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ] }, { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "Thyroid gland neoplasm", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant tumour of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid neoplasm", "description": "" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease", "ebi", "germline" ] }, { "evidence": [ { "id": "P04637", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04637" }, { "id": "rs1131691034", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1131691034" }, { "id": "rs1131691034", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1131691034#frequency_tab" }, { "id": "10709097", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/10709097" }, { "id": "16696020", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/16696020" }, { "id": "17917588", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/17917588" }, { "id": "23033341", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23033341" }, { "id": "9796697", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9796697" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 164, "end_pos": 164, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "K", "sequence_mut": "N", "comment": "Somatic mutation passed 2 out of 6 filters: num. of cancers (5); n-glyco-sequon-gain (KQS->NQS).", "chr_id": "17", "chr_pos": "7675120", "ref_nt": "G", "alt_nt": "T", "minor_allelic_frequency": "", "disease": [ { "disease_id": "DOID:8618", "recommended_name": { "id": "DOID:8618", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8618", "name": "oral cavity cancer", "description": "A gastrointestinal system cancer that is located_in the oral cavity." }, "synonyms": [ { "id": "DOID:8618", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8618", "name": "malignant neoplasm of floor of mouth", "description": "" } ] }, { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Escc, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "gastric cardia adenocarcinoma, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Aerodigestive tract cancer, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ] }, { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast cancer", "description": "A primary or metastatic malignant neoplasm involving the breast. The vast majority of cases are carcinomas arising from the breast parenchyma or the nipple. 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neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant hepato-biliary neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant tumor of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "non-resectable primary hepatic malignant neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary liver cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "resectable malignant neoplasm of the liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, not specified as primary or secondary", "description": "" } ] }, { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "alveolar cell carcinoma", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "Nonsmall cell lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectal adenocarcinoma", "description": "The most common type of colorectal carcinoma. It is characterized by the presence of malignant glandular epithelial cells invading through the muscularis mucosa into the submucosa. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma." }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of the large intestine", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "large bowel adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of large intestine", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectal adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectum adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of the large bowel", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "large intestine adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectal (colon or rectal) adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectal neoplasm", "description": "A benign or malignant neoplasm that affects the colon or rectum. Representative examples of benign neoplasms include lipoma and leiomyoma. Representative examples of malignant neoplasms include carcinoma, lymphoma, and sarcoma. Colorectal adenomas always exhibit epithelial dysplasia and are considered premalignant neoplasms." }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectal tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large bowel neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectum tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large intestinal neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectum neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large bowel tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectal neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "tumor of the large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "tumor of colorectum", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectum neoplasm (disease)", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "tumor of large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large intestine tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large intestine neoplasm", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] }, { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostate cancer", "description": "A primary or metastatic malignant tumor involving the prostate gland. The vast majority are carcinomas." }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant tumor of prostate", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant neoplasm of prostate", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant neoplasm of prostate gland", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant prostate tumor", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant neoplasm of the prostate", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostate neoplasm", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostate gland cancer", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant prostate neoplasm", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostatic cancer", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant tumor of the prostate", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostatic neoplasm", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant prostate gland neoplasm", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "cancer of prostate gland", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "NGP - new growth of prostate", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] }, { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast cancer", "description": "A primary or metastatic malignant neoplasm involving the breast. The vast majority of cases are carcinomas arising from the breast parenchyma or the nipple. 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"http://disease-ontology.org/term/DOID:8618", "name": "malignant neoplasm of floor of mouth", "description": "" } ] }, { "disease_id": "DOID:1319", "recommended_name": { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "brain cancer", "description": "A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain." }, "synonyms": [ { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "BT - Brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "adult brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "adult malignant brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm, adult", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of Brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of adult brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "primary malignant neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "tumor of the Brain", "description": "" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "P04637", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04637" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 202, "end_pos": 202, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "R", "sequence_mut": "S", "comment": "Somatic mutation passed 2 out of 6 filters: num. of cancers (4); n-glyco-sequon-gain (NLR->NLS).", "chr_id": "17", "chr_pos": "7674927", "ref_nt": "C", "alt_nt": "A", "minor_allelic_frequency": "", "disease": [ { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", 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Malignant breast neoplasms occur more frequently in females than in males." }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant tumor of the breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant tumor of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant neoplasm of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "cancer of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant breast tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant neoplasm of the breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant breast neoplasm", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary neoplasm", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast cancer", "description": "A primary or metastatic malignant neoplasm involving the breast. The vast majority of cases are carcinomas arising from the breast parenchyma or the nipple. Malignant breast neoplasms occur more frequently in females than in males." }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant tumor of the breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant tumor of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant neoplasm of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "cancer of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant breast tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant neoplasm of the breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant breast neoplasm", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary neoplasm", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary cancer", "description": "" }, { "id": "MONDO:0010804", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010804", "name": "obsolete BRCATA", "description": "" }, { "id": "MONDO:0010804", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010804", "name": "moved to 114480", "description": "" }, { "id": "MONDO:0010804", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010804", "name": "BRCATA", "description": "" }, { "id": "MONDO:0010804", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010804", "name": "breast cancer, 11-22 translocation-associated", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectal adenocarcinoma", "description": "The most common type of colorectal carcinoma. It is characterized by the presence of malignant glandular epithelial cells invading through the muscularis mucosa into the submucosa. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma." }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of the large intestine", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "large bowel adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of large intestine", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectal adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectum adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of the large bowel", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "large intestine adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectal (colon or rectal) adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectal neoplasm", "description": "A benign or malignant neoplasm that affects the colon or rectum. Representative examples of benign neoplasms include lipoma and leiomyoma. Representative examples of malignant neoplasms include carcinoma, lymphoma, and sarcoma. Colorectal adenomas always exhibit epithelial dysplasia and are considered premalignant neoplasms." }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectal tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large bowel neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectum tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large intestinal neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectum neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large bowel tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectal neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "tumor of the large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "tumor of colorectum", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectum neoplasm (disease)", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "tumor of large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large intestine tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large intestine neoplasm", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] }, { "disease_id": "DOID:8618", "recommended_name": { "id": "DOID:8618", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8618", "name": "oral cavity cancer", "description": "A gastrointestinal system cancer that is located_in the oral cavity." }, "synonyms": [ { "id": "DOID:8618", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8618", "name": "malignant neoplasm of floor of mouth", "description": "" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "P04637", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04637" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 228, "end_pos": 228, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "D", "sequence_mut": "N", "comment": "Somatic mutation passed 2 out of 6 filters: num. of cancers (8); n-glyco-sequon-gain (DCT->NCT).", "chr_id": "17", "chr_pos": "7674281", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast cancer", "description": "A primary or metastatic malignant neoplasm involving the breast. The vast majority of cases are carcinomas arising from the breast parenchyma or the nipple. 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Malignant breast neoplasms occur more frequently in females than in males." }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant tumor of the breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant tumor of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant neoplasm of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "cancer of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant breast tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant neoplasm of the breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant breast neoplasm", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary neoplasm", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary cancer", "description": "" }, { "id": "MONDO:0010804", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010804", "name": "obsolete BRCATA", "description": "" }, { "id": "MONDO:0010804", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010804", "name": "moved to 114480", "description": "" }, { "id": "MONDO:0010804", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010804", "name": "BRCATA", "description": "" }, { "id": "MONDO:0010804", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010804", "name": "breast cancer, 11-22 translocation-associated", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] }, { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": 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"description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer 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"https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] }, { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ] }, { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": 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"description": "" }, { "id": "MIM:603956", "resource": "MIM", "url": "https://www.omim.org/entry/603956", "name": "Cervical cancer", "description": "Cervical cancer" } ] }, { "disease_id": "DOID:2531", "recommended_name": { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematologic cancer", "description": "An organ system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes." }, "synonyms": [ { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "Hematologic malignancy", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "Hematologic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "Hematological 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"DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "primary malignant neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "tumor of the Brain", "description": "" } ] }, { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", 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"https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostate cancer", "description": "A primary or metastatic malignant tumor involving the prostate gland. The vast majority are carcinomas." }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant tumor of prostate", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant neoplasm of prostate", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant neoplasm of prostate gland", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant prostate tumor", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant neoplasm of the prostate", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostate neoplasm", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostate gland cancer", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant prostate neoplasm", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostatic cancer", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant tumor of the prostate", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostatic neoplasm", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant prostate gland neoplasm", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "cancer of prostate gland", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "NGP - new growth of prostate", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] }, { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectal adenocarcinoma", "description": "The most common type of colorectal carcinoma. It is characterized by the presence of malignant glandular epithelial cells invading through the muscularis mucosa into the submucosa. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma." }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of the large intestine", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "large bowel adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of large intestine", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectal adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectum adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of the large bowel", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "large intestine adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectal (colon or rectal) adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectal neoplasm", "description": "A benign or malignant neoplasm that affects the colon or rectum. Representative examples of benign neoplasms include lipoma and leiomyoma. Representative examples of malignant neoplasms include carcinoma, lymphoma, and sarcoma. Colorectal adenomas always exhibit epithelial dysplasia and are considered premalignant neoplasms." }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectal tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large bowel neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectum tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large intestinal neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectum neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large bowel tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectal neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "tumor of the large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "tumor of colorectum", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectum neoplasm (disease)", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "tumor of large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large intestine tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large intestine neoplasm", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] }, { "disease_id": "DOID:8618", "recommended_name": { "id": "DOID:8618", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8618", "name": "oral cavity cancer", "description": "A gastrointestinal system cancer that is located_in the oral cavity." }, "synonyms": [ { "id": "DOID:8618", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8618", "name": "malignant neoplasm of floor of mouth", "description": "" } ] }, { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" 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"https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast cancer", "description": "A primary or metastatic malignant neoplasm involving the breast. The vast majority of cases are carcinomas arising from the breast parenchyma or the nipple. Malignant breast neoplasms occur more frequently in females than in males." }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant tumor of the breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant tumor of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant neoplasm of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "cancer of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant breast tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant neoplasm of the breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant breast neoplasm", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary neoplasm", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast cancer", "description": "A primary or metastatic malignant neoplasm involving the breast. The vast majority of cases are carcinomas arising from the breast parenchyma or the nipple. Malignant breast neoplasms occur more frequently in females than in males." }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant tumor of the breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant tumor of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant neoplasm of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "cancer of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant breast tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant neoplasm of the breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant breast neoplasm", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary neoplasm", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary cancer", "description": "" }, { "id": "MONDO:0010804", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010804", "name": "obsolete BRCATA", "description": "" }, { "id": "MONDO:0010804", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010804", "name": "moved to 114480", "description": "" }, { "id": "MONDO:0010804", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010804", "name": "BRCATA", "description": "" }, { "id": "MONDO:0010804", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010804", "name": "breast cancer, 11-22 translocation-associated", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] }, { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012955", 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the pancreas." }, "synonyms": [ { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of 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"http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] }, { "disease_id": "DOID:1319", "recommended_name": { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "brain cancer", "description": "A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain." }, "synonyms": [ { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", 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"id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "primary malignant neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "tumor of the Brain", "description": "" } ] }, { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": 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The vast majority of cases are carcinomas arising from the breast parenchyma or the nipple. Malignant breast neoplasms occur more frequently in females than in males." }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant tumor of the breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant tumor of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant neoplasm of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "cancer of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant breast tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant neoplasm of the breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant breast neoplasm", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary neoplasm", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast cancer", "description": "A primary or metastatic malignant neoplasm involving the breast. The vast majority of cases are carcinomas arising from the breast parenchyma or the nipple. Malignant breast neoplasms occur more frequently in females than in males." }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant tumor of the breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant tumor of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant neoplasm of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "cancer of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant breast tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant neoplasm of the breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant breast neoplasm", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary neoplasm", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary cancer", "description": "" }, { "id": "MONDO:0010804", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010804", "name": "obsolete BRCATA", "description": "" }, { "id": "MONDO:0010804", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010804", "name": "moved to 114480", "description": "" }, { "id": "MONDO:0010804", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010804", "name": "BRCATA", "description": "" }, { "id": "MONDO:0010804", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010804", "name": "breast cancer, 11-22 translocation-associated", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] }, { "disease_id": "DOID:2394", "recommended_name": { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovarian cancer", "description": "A female reproductive organ cancer that is located_in the ovary." }, "synonyms": [ { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "malignant Ovarian tumor", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "malignant tumour of ovary", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovarian neoplasm", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovary neoplasm", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "primary ovarian cancer", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "tumor of the Ovary", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to, 1", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to, 1", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "OVCAS1", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer", "description": "A primary or metastatic malignant neoplasm involving the ovary. Most primary malignant ovarian neoplasms are either carcinomas (serous, mucinous, or endometrioid adenocarcinomas) or malignant germ cell tumors. Metastatic malignant neoplasms to the ovary include carcinomas, lymphomas, and melanomas." }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant neoplasm of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovary neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "primary ovarian cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian malignant tumor", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumour of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumor of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "cancer of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer, epithelial", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumor of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "cancer of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer, somatic", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovary cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian tumor", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "tumor of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant neoplasm of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovary neoplasm", "description": "" }, { "id": "MIM:167000", "resource": "MIM", "url": "https://www.omim.org/entry/167000", "name": "Ovarian cancer", "description": "Ovarian cancer" } ] }, { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] }, { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant hepato-biliary neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant tumor of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "non-resectable primary hepatic malignant neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary liver cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "resectable malignant neoplasm of the liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, not specified as primary or secondary", "description": "" } ] }, { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostate cancer", "description": "A primary or metastatic malignant tumor involving the prostate gland. The vast majority are carcinomas." }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant tumor of prostate", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant neoplasm of prostate", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant neoplasm of prostate gland", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant prostate tumor", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant neoplasm of the prostate", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostate neoplasm", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostate gland cancer", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant prostate neoplasm", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostatic cancer", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant tumor of the prostate", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostatic neoplasm", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant prostate gland neoplasm", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "cancer of prostate gland", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "NGP - new growth of prostate", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] }, { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "Thyroid gland neoplasm", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant tumour of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid neoplasm", "description": "" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectal adenocarcinoma", "description": "The most common type of colorectal carcinoma. It is characterized by the presence of malignant glandular epithelial cells invading through the muscularis mucosa into the submucosa. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma." }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of the large intestine", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "large bowel adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of large intestine", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectal adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectum adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of the large bowel", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "large intestine adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectal (colon or rectal) adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectal neoplasm", "description": "A benign or malignant neoplasm that affects the colon or rectum. Representative examples of benign neoplasms include lipoma and leiomyoma. Representative examples of malignant neoplasms include carcinoma, lymphoma, and sarcoma. 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"https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectum tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large intestinal neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectum neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large bowel tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectal neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "tumor of the large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "tumor of colorectum", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectum neoplasm (disease)", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "tumor of large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large intestine tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large intestine neoplasm", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] }, { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ] }, { "disease_id": "DOID:8618", "recommended_name": { "id": "DOID:8618", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8618", "name": "oral cavity cancer", "description": "A gastrointestinal system cancer that is located_in the oral cavity." }, "synonyms": [ { "id": "DOID:8618", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8618", "name": "malignant neoplasm of floor of mouth", "description": "" } ] }, { "disease_id": "DOID:1793", "recommended_name": { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic cancer", "description": "An endocrine gland cancer located_in the pancreas." }, "synonyms": [ { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreas 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"recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "alveolar cell carcinoma", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "Nonsmall cell lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectal adenocarcinoma", "description": "The most common type of colorectal carcinoma. It is characterized by the presence of malignant glandular epithelial cells invading through the muscularis mucosa into the submucosa. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma." }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of the large intestine", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "large bowel adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of large intestine", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectal adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectum adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of the large bowel", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "large intestine adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectal (colon or rectal) adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectal neoplasm", "description": "A benign or malignant neoplasm that affects the colon or rectum. Representative examples of benign neoplasms include lipoma and leiomyoma. Representative examples of malignant neoplasms include carcinoma, lymphoma, and sarcoma. Colorectal adenomas always exhibit epithelial dysplasia and are considered premalignant neoplasms." }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectal tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large bowel neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectum tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large intestinal neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectum neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large bowel tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectal neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "tumor of the large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "tumor of colorectum", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectum neoplasm (disease)", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "tumor of large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large intestine tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large intestine neoplasm", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] }, { "disease_id": "DOID:2531", "recommended_name": { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematologic cancer", "description": "An organ system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes." }, "synonyms": [ { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "Hematologic malignancy", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "Hematologic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "Hematological tumors", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "blood cancer", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematopoietic and lymphoid system tumor", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematopoietic cancer", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematopoietic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematopoietic tumors", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "malignant hematopoietic neoplasm", "description": "" } ] }, { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ] }, { "disease_id": "DOID:8618", "recommended_name": { "id": "DOID:8618", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8618", "name": "oral cavity cancer", "description": "A gastrointestinal system cancer that is located_in the oral cavity." }, "synonyms": [ { "id": "DOID:8618", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8618", "name": "malignant neoplasm of floor of mouth", "description": "" } ] }, { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca middle third 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"http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Escc, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell 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"https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Aerodigestive tract cancer, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": 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"description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostate cancer", "description": "A primary or metastatic malignant tumor involving the prostate gland. The vast majority are carcinomas." }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant tumor of prostate", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant neoplasm of prostate", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant neoplasm of prostate gland", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant prostate tumor", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant neoplasm of the prostate", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostate neoplasm", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostate gland cancer", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant prostate neoplasm", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostatic cancer", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant tumor of the prostate", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostatic neoplasm", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant prostate gland neoplasm", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "cancer of prostate gland", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "NGP - new growth of prostate", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] }, { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast cancer", "description": "A primary or metastatic malignant neoplasm involving the breast. The vast majority of cases are carcinomas arising from the breast parenchyma or the nipple. Malignant breast neoplasms occur more frequently in females than in males." }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant tumor of the breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant tumor of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant neoplasm of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "cancer of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant breast tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant neoplasm of the breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant breast neoplasm", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary neoplasm", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast cancer", "description": "A primary or metastatic malignant neoplasm involving the breast. The vast majority of cases are carcinomas arising from the breast parenchyma or the nipple. Malignant breast neoplasms occur more frequently in females than in males." }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant tumor of the breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant tumor of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant neoplasm of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "cancer of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant breast tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant neoplasm of the breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant breast neoplasm", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary neoplasm", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary cancer", "description": "" }, { "id": "MONDO:0010804", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010804", "name": "obsolete BRCATA", "description": "" }, { "id": "MONDO:0010804", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010804", "name": "moved to 114480", "description": "" }, { "id": "MONDO:0010804", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010804", "name": "BRCATA", "description": "" }, { "id": "MONDO:0010804", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010804", "name": "breast cancer, 11-22 translocation-associated", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] }, { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "P04637", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04637" }, { "id": "rs1330865474", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1330865474" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 254, "end_pos": 254, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "I", "sequence_mut": "N", "comment": "Somatic mutation passed 2 out of 6 filters: num. of cancers (7); n-glyco-sequon-gain (IIT->NIT).", "chr_id": "17", "chr_pos": "7674202", "ref_nt": "T", "alt_nt": "A", "minor_allelic_frequency": "", "disease": [ { "disease_id": "DOID:8618", "recommended_name": { "id": "DOID:8618", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8618", "name": "oral cavity cancer", "description": "A gastrointestinal system cancer that is located_in the oral cavity." }, "synonyms": [ { "id": "DOID:8618", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8618", "name": "malignant neoplasm of floor of mouth", "description": "" } ] }, { "disease_id": "DOID:2531", "recommended_name": { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematologic cancer", "description": "An organ system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes." }, "synonyms": [ { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "Hematologic malignancy", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "Hematologic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "Hematological tumors", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "blood cancer", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematopoietic and lymphoid system tumor", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematopoietic cancer", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematopoietic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematopoietic tumors", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "malignant hematopoietic neoplasm", "description": "" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectal adenocarcinoma", "description": "The most common type of colorectal carcinoma. It is characterized by the presence of malignant glandular epithelial cells invading through the muscularis mucosa into the submucosa. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma." }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of the large intestine", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "large bowel adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of large intestine", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectal adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectum adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of the large bowel", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "large intestine adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectal (colon or rectal) adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectal neoplasm", "description": "A benign or malignant neoplasm that affects the colon or rectum. Representative examples of benign neoplasms include lipoma and leiomyoma. Representative examples of malignant neoplasms include carcinoma, lymphoma, and sarcoma. Colorectal adenomas always exhibit epithelial dysplasia and are considered premalignant neoplasms." }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectal tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large bowel neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectum tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large intestinal neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectum neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large bowel tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectal neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "tumor of the large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "tumor of colorectum", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectum neoplasm (disease)", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "tumor of large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large intestine tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large intestine neoplasm", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] }, { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast cancer", "description": "A primary or metastatic malignant neoplasm involving the breast. The vast majority of cases are carcinomas arising from the breast parenchyma or the nipple. Malignant breast neoplasms occur more frequently in females than in males." }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant tumor of the breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant tumor of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant neoplasm of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "cancer of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant breast tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant neoplasm of the breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant breast neoplasm", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary neoplasm", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast cancer", "description": "A primary or metastatic malignant neoplasm involving the breast. The vast majority of cases are carcinomas arising from the breast parenchyma or the nipple. Malignant breast neoplasms occur more frequently in females than in males." }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant tumor of the breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant tumor of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant neoplasm of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "cancer of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant breast tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant neoplasm of the breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant breast neoplasm", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary neoplasm", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary cancer", "description": "" }, { "id": "MONDO:0010804", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010804", "name": "obsolete BRCATA", "description": "" }, { "id": "MONDO:0010804", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010804", "name": "moved to 114480", "description": "" }, { "id": "MONDO:0010804", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010804", "name": "BRCATA", "description": "" }, { "id": "MONDO:0010804", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010804", "name": "breast cancer, 11-22 translocation-associated", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] }, { "disease_id": "DOID:2394", "recommended_name": { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovarian cancer", "description": "A female reproductive organ cancer that is located_in the ovary." }, "synonyms": [ { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "malignant Ovarian tumor", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "malignant tumour of ovary", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovarian neoplasm", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovary neoplasm", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "primary ovarian cancer", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "tumor of the Ovary", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to, 1", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to, 1", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "OVCAS1", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer", "description": "A primary or metastatic malignant neoplasm involving the ovary. Most primary malignant ovarian neoplasms are either carcinomas (serous, mucinous, or endometrioid adenocarcinomas) or malignant germ cell tumors. Metastatic malignant neoplasms to the ovary include carcinomas, lymphomas, and melanomas." }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant neoplasm of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovary neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "primary ovarian cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian malignant tumor", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumour of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumor of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "cancer of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer, epithelial", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumor of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "cancer of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer, somatic", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovary cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian tumor", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "tumor of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant neoplasm of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovary neoplasm", "description": "" }, { "id": "MIM:167000", "resource": "MIM", "url": "https://www.omim.org/entry/167000", "name": "Ovarian cancer", "description": "Ovarian cancer" } ] }, { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant hepato-biliary neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant tumor of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "non-resectable primary hepatic malignant neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary liver cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "resectable malignant neoplasm of the liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": 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"resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": 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"resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm 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"MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Aerodigestive tract cancer, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease", "ebi", "germline" ] }, { "evidence": [ { "id": "P04637", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04637" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 259, "end_pos": 259, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "D", "sequence_mut": "N", "comment": "Somatic mutation passed 2 out of 6 filters: num. of cancers (8); n-glyco-sequon-gain (DSS->NSS).", "chr_id": "17", "chr_pos": "7674188", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "disease": [ { "disease_id": "DOID:4606", "recommended_name": { "id": "DOID:4606", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4606", "name": "bile duct cancer", "description": "A biliary tract cancer that is located_in the bile duct." }, "synonyms": [ { "id": "DOID:4606", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4606", "name": "Ca extrahepatic bile ducts", "description": "" }, { "id": "DOID:4606", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4606", "name": "bile duct tumor", "description": "" }, { "id": "DOID:4606", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4606", "name": "malignant neoplasm of the extrahepatic bile duct", "description": "" } ] }, { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectal adenocarcinoma", "description": "The most common type of colorectal carcinoma. It is characterized by the presence of malignant glandular epithelial cells invading through the muscularis mucosa into the submucosa. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma." }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of the large intestine", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "large bowel adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of large intestine", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectal adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectum adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of the large bowel", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "large intestine adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectal (colon or rectal) adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectal neoplasm", "description": "A benign or malignant neoplasm that affects the colon or rectum. Representative examples of benign neoplasms include lipoma and leiomyoma. Representative examples of malignant neoplasms include carcinoma, lymphoma, and sarcoma. Colorectal adenomas always exhibit epithelial dysplasia and are considered premalignant neoplasms." }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectal tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large bowel neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectum tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large intestinal neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectum neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large bowel tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectal neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "tumor of the large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "tumor of colorectum", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectum neoplasm (disease)", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "tumor of large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large intestine tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large intestine neoplasm", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] }, { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast cancer", "description": "A primary or metastatic malignant neoplasm involving the breast. The vast majority of cases are carcinomas arising from the breast parenchyma or the nipple. Malignant breast neoplasms occur more frequently in females than in males." }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant tumor of the breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant tumor of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant neoplasm of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "cancer of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant breast tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant neoplasm of the breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant breast neoplasm", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary neoplasm", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast cancer", "description": "A primary or metastatic malignant neoplasm involving the breast. The vast majority of cases are carcinomas arising from the breast parenchyma or the nipple. Malignant breast neoplasms occur more frequently in females than in males." }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant tumor of the breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant tumor of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant neoplasm of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "cancer of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant breast tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant neoplasm of the breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant breast neoplasm", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary neoplasm", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary cancer", "description": "" }, { "id": "MONDO:0010804", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010804", "name": "obsolete BRCATA", "description": "" }, { "id": "MONDO:0010804", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010804", "name": "moved to 114480", "description": "" }, { "id": "MONDO:0010804", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010804", "name": "BRCATA", "description": "" }, { "id": "MONDO:0010804", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010804", "name": "breast cancer, 11-22 translocation-associated", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] }, { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ] }, { "disease_id": "DOID:2531", "recommended_name": { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematologic cancer", "description": "An organ system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes." }, "synonyms": [ { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "Hematologic malignancy", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "Hematologic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "Hematological tumors", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "blood cancer", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematopoietic and lymphoid system tumor", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematopoietic cancer", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematopoietic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematopoietic tumors", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "malignant hematopoietic neoplasm", "description": "" } ] }, { "disease_id": "DOID:2394", "recommended_name": { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovarian cancer", "description": "A female reproductive organ cancer that is located_in the ovary." }, "synonyms": [ { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "malignant Ovarian tumor", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "malignant tumour of ovary", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovarian neoplasm", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovary neoplasm", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "primary ovarian cancer", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "tumor of the Ovary", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to, 1", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to, 1", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "OVCAS1", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer", "description": "A primary or metastatic malignant neoplasm involving the ovary. Most primary malignant ovarian neoplasms are either carcinomas (serous, mucinous, or endometrioid adenocarcinomas) or malignant germ cell tumors. Metastatic malignant neoplasms to the ovary include carcinomas, lymphomas, and melanomas." }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant neoplasm of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovary neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "primary ovarian cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian malignant tumor", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumour of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumor of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "cancer of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer, epithelial", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumor of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "cancer of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer, somatic", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovary cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian tumor", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "tumor of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant neoplasm of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovary neoplasm", "description": "" }, { "id": "MIM:167000", "resource": "MIM", "url": "https://www.omim.org/entry/167000", "name": "Ovarian cancer", "description": "Ovarian cancer" } ] }, { "disease_id": "DOID:8618", "recommended_name": { "id": "DOID:8618", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8618", "name": "oral cavity cancer", "description": "A gastrointestinal system cancer that is located_in the oral cavity." }, "synonyms": [ { "id": "DOID:8618", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8618", "name": "malignant neoplasm of floor of mouth", "description": "" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "P04637", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04637" }, { "id": "rs1057519986", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1057519986" }, { "id": "rs1057519986", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1057519986" }, { "id": "rs1057519986", "database": "NCI-TCGA", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1057519986" }, { "id": "10070948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/10070948" }, { "id": "11004672", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/11004672" }, { "id": "11588905", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/11588905" }, { "id": "12771990", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/12771990" }, { "id": "1483940", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/1483940" }, { "id": "18772890", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/18772890" }, { "id": "21665242", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/21665242" }, { "id": "23407552", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23407552" }, { "id": "8569192", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/8569192" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 270, "end_pos": 270, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "F", "sequence_mut": "S", "comment": "Somatic mutation passed 2 out of 6 filters: num. of cancers (13); n-glyco-sequon-gain (NSF->NSS).", "chr_id": "17", "chr_pos": "7673811", "ref_nt": "T", "alt_nt": "C", "minor_allelic_frequency": "", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] }, { "disease_id": "DOID:2394", "recommended_name": { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovarian cancer", "description": "A female reproductive organ cancer that is located_in the ovary." }, "synonyms": [ { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "malignant Ovarian tumor", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "malignant tumour of ovary", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovarian neoplasm", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovary neoplasm", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "primary ovarian cancer", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "tumor of the Ovary", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to, 1", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to, 1", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "OVCAS1", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer", "description": "A primary or metastatic malignant neoplasm involving the ovary. Most primary malignant ovarian neoplasms are either carcinomas (serous, mucinous, or endometrioid adenocarcinomas) or malignant germ cell tumors. Metastatic malignant neoplasms to the ovary include carcinomas, lymphomas, and melanomas." }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant neoplasm of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovary neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "primary ovarian cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian malignant tumor", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumour of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumor of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "cancer of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer, epithelial", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumor of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "cancer of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer, somatic", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovary cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian tumor", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "tumor of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant neoplasm of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovary neoplasm", "description": "" }, { "id": "MIM:167000", "resource": "MIM", "url": "https://www.omim.org/entry/167000", "name": "Ovarian cancer", "description": "Ovarian cancer" } ] }, { "disease_id": "DOID:8618", "recommended_name": { "id": "DOID:8618", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8618", "name": "oral cavity cancer", "description": "A gastrointestinal system cancer that is located_in the oral cavity." }, "synonyms": [ { "id": "DOID:8618", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8618", "name": "malignant neoplasm of floor of mouth", "description": "" } ] }, { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant hepato-biliary neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant tumor of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "non-resectable primary hepatic malignant neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary liver cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "resectable malignant neoplasm of the liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, not specified as primary or secondary", "description": "" } ] }, { "disease_id": "DOID:2531", "recommended_name": { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematologic cancer", "description": "An organ system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes." }, "synonyms": [ { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "Hematologic malignancy", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "Hematologic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "Hematological tumors", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "blood cancer", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematopoietic and lymphoid system tumor", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematopoietic cancer", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematopoietic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematopoietic tumors", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "malignant hematopoietic neoplasm", "description": "" } ] }, { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] }, { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Escc, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "gastric cardia adenocarcinoma, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Aerodigestive tract cancer, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ] }, { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast cancer", "description": "A primary or metastatic malignant neoplasm involving the breast. The vast majority of cases are carcinomas arising from the breast parenchyma or the nipple. Malignant breast neoplasms occur more frequently in females than in males." }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant tumor of the breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant tumor of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant neoplasm of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "cancer of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant breast tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant neoplasm of the breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant breast neoplasm", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary neoplasm", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast cancer", "description": "A primary or metastatic malignant neoplasm involving the breast. The vast majority of cases are carcinomas arising from the breast parenchyma or the nipple. Malignant breast neoplasms occur more frequently in females than in males." }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant tumor of the breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant tumor of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant neoplasm of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "cancer of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant breast tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant neoplasm of the breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant breast neoplasm", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary neoplasm", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary cancer", "description": "" }, { "id": "MONDO:0010804", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010804", "name": "obsolete BRCATA", "description": "" }, { "id": "MONDO:0010804", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010804", "name": "moved to 114480", "description": "" }, { "id": "MONDO:0010804", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010804", "name": "BRCATA", "description": "" }, { "id": "MONDO:0010804", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010804", "name": "breast cancer, 11-22 translocation-associated", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] }, { "disease_id": "DOID:1793", "recommended_name": { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic cancer", "description": "An endocrine gland cancer located_in the pancreas." }, "synonyms": [ { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreas neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic tumor", "description": "" } ] }, { "disease_id": "DOID:1319", "recommended_name": { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "brain cancer", "description": "A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain." }, "synonyms": [ { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "BT - Brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "adult brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "adult malignant brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm, adult", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of Brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of adult brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "primary malignant neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "tumor of the Brain", "description": "" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectal adenocarcinoma", "description": "The most common type of colorectal carcinoma. It is characterized by the presence of malignant glandular epithelial cells invading through the muscularis mucosa into the submucosa. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma." }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of the large intestine", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "large bowel adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of large intestine", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectal adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectum adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of the large bowel", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "large intestine adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectal (colon or rectal) adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectal neoplasm", "description": "A benign or malignant neoplasm that affects the colon or rectum. 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"https://monarchinitiative.org/disease/MONDO:0005335", "name": "tumor of colorectum", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectum neoplasm (disease)", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "tumor of large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large intestine tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large intestine neoplasm", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] }, { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": 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"description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor 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"url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04637" }, { "id": "rs1597349147", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1597349147" }, { "id": "rs1597349147", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1597349147" }, { "id": "15138567", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/15138567" }, { "id": "18772890", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/18772890" }, { "id": "23104868", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23104868" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 347, "end_pos": 347, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "A", "sequence_mut": "T", "comment": "Somatic mutation passed 2 out of 6 filters: num. of cancers (4); n-glyco-sequon-gain (NEA->NET).", "chr_id": "17", "chr_pos": "7670670", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "disease": [ { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectal adenocarcinoma", "description": "The most common type of colorectal carcinoma. 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"url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "alveolar cell carcinoma", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "Nonsmall cell lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] }, { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] }, { "disease_id": "DOID:2531", "recommended_name": { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematologic cancer", "description": "An organ system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes." }, "synonyms": [ { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "Hematologic malignancy", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "Hematologic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "Hematological tumors", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "blood cancer", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematopoietic and lymphoid system tumor", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematopoietic cancer", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematopoietic neoplasm", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematopoietic tumors", "description": "" }, { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "malignant hematopoietic neoplasm", "description": "" } ] }, { "disease_id": "DOID:2394", "recommended_name": { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovarian cancer", "description": "A female reproductive organ cancer that is located_in the ovary." }, "synonyms": [ { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "malignant Ovarian tumor", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "malignant tumour of ovary", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovarian neoplasm", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovary neoplasm", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "primary ovarian cancer", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "tumor of the Ovary", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to, 1", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to, 1", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "OVCAS1", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer", "description": "A primary or metastatic malignant neoplasm involving the ovary. Most primary malignant ovarian neoplasms are either carcinomas (serous, mucinous, or endometrioid adenocarcinomas) or malignant germ cell tumors. Metastatic malignant neoplasms to the ovary include carcinomas, lymphomas, and melanomas." }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant neoplasm of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovary neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "primary ovarian cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian malignant tumor", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumour of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumor of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "cancer of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer, epithelial", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumor of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "cancer of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer, somatic", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovary cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian tumor", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "tumor of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant neoplasm of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovary neoplasm", "description": "" }, { "id": "MIM:167000", "resource": "MIM", "url": "https://www.omim.org/entry/167000", "name": "Ovarian cancer", "description": "Ovarian cancer" } ] }, { "disease_id": "DOID:1245", "recommended_name": { "id": "DOID:1245", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1245", "name": "vulva cancer", "description": "A female reproductive organ cancer that is located_in the vulva." }, "synonyms": [ { "id": "DOID:1245", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1245", "name": "Ca vulva", "description": "" }, { "id": "DOID:1245", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1245", "name": "Vulvar tumor", "description": "" }, { "id": "DOID:1245", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1245", "name": "malignant Vulvar tumor", "description": "" }, { "id": "DOID:1245", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1245", "name": "malignant neoplasm of vulva", "description": "" }, { "id": "DOID:1245", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1245", "name": "malignant tumor of vulva", "description": "" }, { "id": "DOID:1245", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1245", "name": "neoplasm of vulva", "description": "" }, { "id": "DOID:1245", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1245", "name": "vulval cancer", "description": "" }, { "id": "DOID:1245", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1245", "name": "vulval neoplasm", "description": "" }, { "id": "DOID:1245", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1245", "name": "vulvar neoplasm", "description": "" } ] }, { "disease_id": "DOID:8618", "recommended_name": { "id": "DOID:8618", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8618", "name": "oral cavity cancer", "description": "A gastrointestinal system cancer that is located_in the oral cavity." }, "synonyms": [ { "id": "DOID:8618", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:8618", "name": "malignant neoplasm of floor of mouth", "description": "" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectal adenocarcinoma", "description": "The most common type of colorectal carcinoma. It is characterized by the presence of malignant glandular epithelial cells invading through the muscularis mucosa into the submucosa. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma." }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of the large intestine", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "large bowel adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of large intestine", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectal adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectum adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of the large bowel", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "large intestine adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectal (colon or rectal) adenocarcinoma", "description": "" }, { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "adenocarcinoma of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectal neoplasm", "description": "A benign or malignant neoplasm that affects the colon or rectum. Representative examples of benign neoplasms include lipoma and leiomyoma. Representative examples of malignant neoplasms include carcinoma, lymphoma, and sarcoma. Colorectal adenomas always exhibit epithelial dysplasia and are considered premalignant neoplasms." }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectal tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large bowel neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectum tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large intestinal neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectum neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large bowel tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectal neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "tumor of the large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "tumor of colorectum", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectum neoplasm (disease)", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "tumor of large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large intestine tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large intestine neoplasm", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] }, { "disease_id": "DOID:1793", "recommended_name": { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic cancer", "description": "An endocrine gland cancer located_in the pancreas." }, "synonyms": [ { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreas neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic tumor", "description": "" } ] }, { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast cancer", "description": "A primary or metastatic malignant neoplasm involving the breast. The vast majority of cases are carcinomas arising from the breast parenchyma or the nipple. Malignant breast neoplasms occur more frequently in females than in males." }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant tumor of the breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant tumor of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant neoplasm of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "cancer of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant breast tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant neoplasm of the breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant breast neoplasm", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary neoplasm", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast cancer", "description": "A primary or metastatic malignant neoplasm involving the breast. The vast majority of cases are carcinomas arising from the breast parenchyma or the nipple. Malignant breast neoplasms occur more frequently in females than in males." }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant tumor of the breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant tumor of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant neoplasm of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "cancer of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant breast tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant neoplasm of the breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant breast neoplasm", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary neoplasm", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary cancer", "description": "" }, { "id": "MONDO:0010804", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010804", "name": "obsolete BRCATA", "description": "" }, { "id": "MONDO:0010804", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010804", "name": "moved to 114480", "description": "" }, { "id": "MONDO:0010804", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010804", "name": "BRCATA", "description": "" }, { "id": "MONDO:0010804", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010804", "name": "breast cancer, 11-22 translocation-associated", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] }, { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", 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"https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Escc, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "gastric cardia adenocarcinoma, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Aerodigestive tract cancer, susceptibility to", "description": "" }, { 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"frequency": "0.0", "sequence_org": "Y", "sequence_mut": "*", "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (11).", "chr_id": "17", "chr_pos": "7676060", "ref_nt": "C", "alt_nt": "G", "minor_allelic_frequency": "", "disease": [ { "disease_id": "DOID:1793", "recommended_name": { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic cancer", "description": "An endocrine gland cancer located_in the pancreas." }, "synonyms": [ { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreas neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic tumor", "description": "" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005008", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005008", "name": "colorectal adenocarcinoma", "description": "The most common type of colorectal carcinoma. 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Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectal neoplasm", "description": "A benign or malignant neoplasm that affects the colon or rectum. Representative examples of benign neoplasms include lipoma and leiomyoma. Representative examples of malignant neoplasms include carcinoma, lymphoma, and sarcoma. Colorectal adenomas always exhibit epithelial dysplasia and are considered premalignant neoplasms." }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectal tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large bowel neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectum tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large intestinal neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectum neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large bowel tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectal neoplasm", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "tumor of the large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "tumor of colorectum", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "colorectum neoplasm (disease)", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "tumor of large bowel", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large intestine tumor", "description": "" }, { "id": "MONDO:0005335", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005335", "name": "large intestine neoplasm", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] }, { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophagus 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tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] }, { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ] }, { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast cancer", "description": "A primary or metastatic malignant neoplasm involving the breast. The vast majority of cases are carcinomas arising from the breast parenchyma or the nipple. Malignant breast neoplasms occur more frequently in females than in males." }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant tumor of the breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant tumor of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant neoplasm of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "cancer of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant breast tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant neoplasm of the breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant breast neoplasm", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary neoplasm", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast cancer", "description": "A primary or metastatic malignant neoplasm involving the breast. The vast majority of cases are carcinomas arising from the breast parenchyma or the nipple. Malignant breast neoplasms occur more frequently in females than in males." }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant tumor of the breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant tumor of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant neoplasm of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "cancer of breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant breast tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant neoplasm of the breast", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "malignant breast neoplasm", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast cancer", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast tumor", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary neoplasm", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "mammary cancer", "description": "" }, { "id": "MONDO:0010804", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010804", "name": "obsolete BRCATA", "description": "" }, { "id": "MONDO:0010804", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010804", "name": "moved to 114480", "description": "" }, { "id": "MONDO:0010804", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010804", "name": "BRCATA", "description": "" }, { "id": "MONDO:0010804", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010804", "name": "breast cancer, 11-22 translocation-associated", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] }, { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostate cancer", "description": "A primary or metastatic malignant tumor involving the prostate gland. The vast majority are carcinomas." }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant tumor of prostate", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant neoplasm of prostate", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant neoplasm of prostate gland", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant prostate tumor", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", 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"database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "10023775", "url": "https://glygen.org/publication/PubMed/10023775" } ] }, { "title": "p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2.", "journal": "Science (New York, N.Y.)", "date": "1999", "authors": "Karlseder J, Broccoli D, Dai Y, Hardy S, de Lange T", "evidence": [ { "database": "Reactome", "id": "R-HSA-2559586", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2559586" } ], "reference": [ { "type": "PubMed", "id": "10037601", "url": "https://glygen.org/publication/PubMed/10037601" } ] }, { "title": "p53 mutants without a functional tetramerisation domain are not oncogenic.", "journal": "Journal of molecular biology", "date": "1999", "authors": "Chene P, Bechter E", "evidence": [ { "database": "Reactome", "id": "R-HSA-9723905", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9723905" } ], "reference": [ { "type": "PubMed", "id": "10064694", "url": "https://glygen.org/publication/PubMed/10064694" } ] }, { "title": "Frequency of p53 mutations in breast carcinomas from Ashkenazi Jewish carriers of BRCA1 mutations.", "journal": "Journal of the National Cancer Institute", "date": "1999", "authors": "Phillips KA, Nichol K, Ozcelik H, Knight J, Done SJ, Goodwin PJ, Andrulis IL", "evidence": [ { "database": "dbSNP", "id": "rs1057519986", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1057519986" } ], "reference": [ { "type": "PubMed", "id": "10070948", "url": "https://glygen.org/publication/PubMed/10070948" } ] }, { "title": "Requirement of ATM in phosphorylation of the human p53 protein at serine 15 following DNA double-strand breaks.", "journal": "Molecular and cellular biology", "date": "1999", "authors": "Nakagawa K, Taya Y, Tamai K, Yamaizumi M", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": 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Koole R, Hordijk GJ, Slootweg PJ, Tilanus MG", "evidence": [ { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ { "type": "PubMed", "id": "10092071", "url": "https://glygen.org/publication/PubMed/10092071" } ] }, { "title": "Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2.", "journal": "The Biochemical journal", "date": "1999", "authors": "Kobayashi T, Cohen P", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804757", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804757" } ], "reference": [ { "type": "PubMed", "id": "10191262", "url": "https://glygen.org/publication/PubMed/10191262" } ] }, { "title": "Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells.", "journal": "Nature", "date": "1999", "authors": "Tetsu O, McCormick F", "evidence": [ { "database": "Reactome", "id": "R-HSA-8853884", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8853884" } ], "reference": [ { "type": "PubMed", "id": "10201372", "url": "https://glygen.org/publication/PubMed/10201372" } ] }, { "title": "DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization.", "journal": "The EMBO journal", "date": "1999", "authors": "Shieh SY, Taya Y, Prives C", "evidence": [ { "database": "iPTMnet", "id": "P04637-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637-1" } ], "reference": [ { "type": "PubMed", "id": "10202145", "url": "https://glygen.org/publication/PubMed/10202145" } ] }, { "title": "DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation.", "journal": "Oncogene", "date": "1999", "authors": "Blattner C, Tobiasch E, Litfen M, Rahmsdorf HJ, Herrlich P", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "10208433", "url": "https://glygen.org/publication/PubMed/10208433" } ] }, { "title": "Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface.", "journal": "Cell", "date": "1999", "authors": "Hage T, Sebald W, Reinemer P", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "10219247", "url": "https://glygen.org/publication/PubMed/10219247" } ] }, { "title": "The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1999", "authors": "Shtutman M, Zhurinsky J, Simcha I, Albanese C, D'Amico M, Pestell R, Ben-Ze'ev A", "evidence": [ { "database": "Reactome", "id": "R-HSA-8853884", "url": 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"R-HSA-6804759", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804759" } ], "reference": [ { "type": "PubMed", "id": "10329733", "url": "https://glygen.org/publication/PubMed/10329733" } ] }, { "title": "Importance of glucose-6-phosphate dehydrogenase activity in cell death.", "journal": "The American journal of physiology", "date": "1999", "authors": "Tian WN, Braunstein LD, Apse K, Pang J, Rose M, Tian X, Stanton RC", "evidence": [ { "database": "Reactome", "id": "R-HSA-5628897", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5628897" } ], "reference": [ { "type": "PubMed", "id": "10329961", "url": "https://glygen.org/publication/PubMed/10329961" } ] }, { "title": "Oligomerization is required for p53 to be efficiently ubiquitinated by MDM2.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Maki CG", "evidence": [ { "database": "Reactome", "id": "R-HSA-2559580", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2559580" } ], "reference": [ { "type": "PubMed", "id": "10347217", "url": "https://glygen.org/publication/PubMed/10347217" } ] }, { "title": "The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro.", "journal": "Oncogene", "date": "1999", "authors": "Cuddihy AR, Wong AH, Tam NW, Li S, Koromilas AE", "evidence": [ { "database": "iPTMnet", "id": "P04637-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637-1" } ], "reference": [ { "type": "PubMed", "id": "10348343", "url": "https://glygen.org/publication/PubMed/10348343" } ] }, { "title": "p300/cAMP-responsive element-binding protein interactions with ets-1 and ets-2 in the transcriptional activation of the human stromelysin promoter.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Jayaraman G, Srinivas R, Duggan C, Ferreira E, Swaminathan S, Somasundaram K, Williams J, Hauser C, Kurkinen M, Dhar R, Weitzman S, Buttice G, Thimmapaya B", "evidence": [ { "database": "Reactome", "id": "R-HSA-2559585", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2559585" } ], "reference": [ { "type": "PubMed", "id": "10358095", "url": "https://glygen.org/publication/PubMed/10358095" } ] }, { "title": "The need for microdissectional tumor cell preparation during the molecular genetic analysis of prostate cancer.", "journal": "World journal of urology", "date": "1999", "authors": "Kuczyk M, Serth J, Bokemeyer C, Machtens S, Schwede J, Herrmann R, Paeslack U, Truss MC, Knuchel R, Jonas U", "evidence": [ { "database": "dbSNP", "id": "rs587782329", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs587782329" } ], "reference": [ { "type": "PubMed", "id": "10367371", "url": "https://glygen.org/publication/PubMed/10367371" } ] }, { "title": "Regulation of the germline immunoglobulin Cgamma1 promoter by CD40 ligand and IL-4: dual role for tandem NF-kappaB binding sites.", "journal": "Molecular immunology", "date": "1999", "authors": "Warren WD, Roberts KL, Linehan LA, Berton MT", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "10369418", "url": "https://glygen.org/publication/PubMed/10369418" } ] }, { "title": "The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN.", "journal": "The Journal of cell biology", "date": "1999", "authors": "Heyninck K, De Valck D, Vanden Berghe W, Van Criekinge W, Contreras R, Fiers W, Haegeman G, Beyaert R", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689896", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689896" } ], "reference": [ { "type": "PubMed", "id": "10385526", "url": "https://glygen.org/publication/PubMed/10385526" } ] }, { "title": "Different frequencies of p53 codon-249 hot-spot mutations in hepatocellular carcinomas in Jiang-su province of China.", "journal": "International journal of cancer", "date": "1999", "authors": "Shimizu Y, Zhu JJ, Han F, Ishikawa T, Oda H", "evidence": [ { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ { "type": "PubMed", "id": "10389750", "url": "https://glygen.org/publication/PubMed/10389750" } ] }, { "title": "Genetic alterations in hepatocellular carcinomas: association between loss of chromosome 4q and p53 gene mutations.", "journal": "British journal of cancer", "date": "1999", "authors": "Rashid A, Wang JS, Qian GS, Lu BX, Hamilton SR, Groopman JD", "evidence": [ { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ { "type": "PubMed", "id": "10389978", "url": "https://glygen.org/publication/PubMed/10389978" } ] }, { "title": "Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis.", "journal": "The EMBO journal", "date": "1999", "authors": "Hu Y, Benedict MA, Ding L, Nunez G", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803207" } ], "reference": [ { "type": "PubMed", "id": "10393175", "url": "https://glygen.org/publication/PubMed/10393175" } ] }, { "title": "The p38MAPK inhibitor SB203580 alleviates ultraviolet-induced phosphorylation at serine 389 but not serine 15 and activation of p53.", "journal": "Biochemical and biophysical research communications", "date": "1999", "authors": "Keller D, Zeng X, Li X, Kapoor M, Iordanov MS, Taya Y, Lozano G, Magun B, Lu H", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ 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research", "date": "1999", "authors": "Araki R, Fukumura R, Fujimori A, Taya Y, Shiloh Y, Kurimasa A, Burma S, Li GC, Chen DJ, Sato K, Hoki Y, Tatsumi K, Abe M", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "10446957", "url": "https://glygen.org/publication/PubMed/10446957" } ] }, { "title": "Hereditary TP53 codon 292 and somatic P16INK4A codon 94 mutations in a Li-Fraumeni syndrome family.", "journal": "Cancer Genet. 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Chem.", "date": "1999", "authors": "Clarke M.F., Liang S.H.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "10551826", "url": "https://glygen.org/publication/PubMed/10551826" } ] }, { "title": "One mechanism for cell type-specific regulation of the bax promoter by the tumor suppressor p53 is dictated by the p53 response element.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Thornborrow EC, Manfredi JJ", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "10559267", "url": "https://glygen.org/publication/PubMed/10559267" } ] }, { "title": "Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage.", "journal": "Proc. Natl. Acad. Sci. 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Mol. Biol.", "date": "2000", "authors": "Thibault P., Kelly J., Benchimol S., Abraham J.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "10656795", "url": "https://glygen.org/publication/PubMed/10656795" } ] }, { "title": "Control of human telomere length by TRF1 and TRF2.", "journal": "Molecular and cellular biology", "date": "2000", "authors": "Smogorzewska A, van Steensel B, Bianchi A, Oelmann S, Schaefer MR, Schnapp G, de Lange T", "evidence": [ { "database": "Reactome", "id": "R-HSA-2559586", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2559586" } ], "reference": [ { "type": "PubMed", "id": "10669743", "url": "https://glygen.org/publication/PubMed/10669743" } ] }, { "title": "Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53.", 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"id": "10673501", "url": "https://glygen.org/publication/PubMed/10673501" } ] }, { "title": "Prognostic significance of mutations to different structural and functional regions of the p53 gene in breast cancer.", "journal": "Clinical cancer research : an official journal of the American Association for Cancer Research", "date": "2000", "authors": "Powell B, Soong R, Iacopetta B, Seshadri R, Smith DR", "evidence": [ { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ { "type": "PubMed", "id": "10690522", "url": "https://glygen.org/publication/PubMed/10690522" } ] }, { "title": "p53 gene mutation, tumor p53 protein overexpression, and serum p53 autoantibody generation in patients with breast cancer.", "journal": "Clinical biochemistry", "date": "2000", "authors": "Angelopoulou K, Yu H, Bharaj B, Giai M, Diamandis EP", "evidence": [ { "database": "dbSNP", "id": "rs587782329", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs587782329" } ], "reference": [ { "type": "PubMed", "id": "10693987", "url": "https://glygen.org/publication/PubMed/10693987" } ] }, { "title": "Nuclear targeting of the beta isoform of type II phosphatidylinositol phosphate kinase (phosphatidylinositol 5-phosphate 4-kinase) by its alpha-helix 7.", "journal": "The Biochemical journal", "date": "2000", "authors": "Ciruela A, Hinchliffe KA, Divecha N, Irvine RF", "evidence": [ { "database": "Reactome", "id": "R-HSA-6811555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811555" } ], "reference": [ { "type": "PubMed", "id": "10698683", "url": "https://glygen.org/publication/PubMed/10698683" } ] }, { "title": "Relating genotype and phenotype in breast cancer: an analysis of the prognostic significance of amplification at eight different genes or loci and of p53 mutations.", "journal": "Cancer research", "date": "2000", "authors": "Cuny M, Kramar A, Courjal F, Johannsdottir V, Iacopetta B, Fontaine H, Grenier J, Culine S, Theillet C", "evidence": [ { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ { "type": "PubMed", "id": "10706127", "url": "https://glygen.org/publication/PubMed/10706127" } ] }, { "title": "Circulating p53 antibodies, p53 gene mutational profile and product accumulation in esophageal squamous-cell carcinoma in India.", "journal": "International journal of cancer", "date": "2000", "authors": "Ralhan R, Arora S, Chattopadhyay TK, Shukla NK, Mathur M", "evidence": [ { "database": "dbSNP", "id": "rs1131691034", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1131691034" } ], "reference": [ { "type": "PubMed", "id": "10709097", "url": "https://glygen.org/publication/PubMed/10709097" } ] }, { "title": "DNA damage-induced activation of p53 by the checkpoint kinase Chk2.", "journal": "Science (New York, N.Y.)", "date": "2000", "authors": "Hirao A, Kong YY, Matsuoka S, Wakeham A, Ruland J, Yoshida H, Liu D, Elledge SJ, Mak TW", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804756", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804756" }, { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "10710310", "url": "https://glygen.org/publication/PubMed/10710310" } ] }, { "title": "Purification and characterization of ATM from human placenta. A manganese-dependent, wortmannin-sensitive serine/threonine protein kinase.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Chan DW, Son SC, Block W, Ye R, Khanna KK, Wold MS, Douglas P, Goodarzi AA, Pelley J, Taya Y, Lavin MF, Lees-Miller SP", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "10713094", "url": "https://glygen.org/publication/PubMed/10713094" } ] }, { "title": "A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage.", "journal": "Nature", "date": "2000", "authors": "Tanaka H, Arakawa H, Yamaguchi T, Shiraishi K, Fukuda S, Matsui K, Takei Y, Nakamura Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-5628897", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5628897" } ], "reference": [ { "type": "PubMed", "id": "10716435", "url": "https://glygen.org/publication/PubMed/10716435" } ] }, { "title": "Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53.", "journal": "J. Biol. Chem.", "date": "2000", "authors": "Vousden K.H., Fang S., Jensen J.P., Weissman A.M., Ludwig R.L.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "Reactome", "id": "R-HSA-2559580", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2559580" } ], "reference": [ { "type": "PubMed", "id": "10722742", "url": "https://glygen.org/publication/PubMed/10722742" } ] }, { "title": "Ionizing radiation activates the ATM kinase throughout the cell cycle.", "journal": "Oncogene", "date": "2000", "authors": "Pandita TK, Lieberman HB, Lim DS, Dhar S, Zheng W, Taya Y, Kastan MB", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "10723129", "url": "https://glygen.org/publication/PubMed/10723129" } ] }, { "title": "hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response.", "journal": "Nature", "date": "2000", "authors": "Lee JS, Collins KM, Brown AL, Lee CH, Chung JH", "evidence": [ { "database": "Reactome", "id": "R-HSA-5693565", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5693565" } ], "reference": [ { "type": "PubMed", "id": "10724175", "url": "https://glygen.org/publication/PubMed/10724175" } ] }, { "title": "PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family.", "journal": "Genes & development", "date": "2000", "authors": "Attardi LD, Reczek EE, Cosmas C, Demicco EG, McCurrach ME, Lowe SW, Jacks T", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803205", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803205" } ], "reference": [ { "type": "PubMed", "id": "10733530", "url": "https://glygen.org/publication/PubMed/10733530" } ] }, { "title": "Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Sakaguchi K, Saito S, Higashimoto Y, Roy S, Anderson CW, Appella E", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "10734067", "url": "https://glygen.org/publication/PubMed/10734067" } ] }, { "title": "HTLV-1 tax oncoprotein represses the p53-mediated trans-activation function through coactivator CBP sequestration.", "journal": "Oncogene", "date": "2000", "authors": "Ariumi Y, Kaida A, Lin JY, Hirota M, Masui O, Yamaoka S, Taya Y, Shimotohno K", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "10734308", "url": "https://glygen.org/publication/PubMed/10734308" } ] }, { "title": "[Sequence alterations in p53 gene of hepatocellular carcinoma from high aflatoxin risk area in Guangxi].", "journal": "Zhonghua zhong liu za zhi [Chinese journal of oncology]", "date": "1997", "authors": "Deng Z, Pan L, Ma Y", "evidence": [ { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ { "type": "PubMed", "id": "10743047", "url": "https://glygen.org/publication/PubMed/10743047" } ] }, { "title": "Human glucose-6-phosphate dehydrogenase: the crystal structure reveals a structural NADP(+) molecule and provides insights into enzyme deficiency.", "journal": "Structure (London, England : 1993)", "date": "2000", "authors": "Au SW, Gover S, Lam VM, Adams MJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-5628897", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5628897" } ], "reference": [ { "type": "PubMed", "id": "10745013", "url": "https://glygen.org/publication/PubMed/10745013" } ] }, { "title": "Stress-induced activation of protein kinase CK2 by direct interaction with p38 mitogen-activated protein kinase.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Sayed M, Kim SO, Salh BS, Issinger OG, Pelech SL", "evidence": [ { "database": "iPTMnet", "id": "P04637-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637-1" } ], "reference": [ { "type": "PubMed", "id": "10747897", "url": "https://glygen.org/publication/PubMed/10747897" } ] }, { "title": "A DNA damage signal is required for p53 to activate gadd45.", "journal": "Cancer research", "date": "2000", "authors": "Xiao G, Chicas A, Olivier M, Taya Y, Tyagi S, Kramer FR, Bargonetti J", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "10749144", "url": "https://glygen.org/publication/PubMed/10749144" } ] }, { "title": "ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway.", "journal": "Nature", "date": "2000", "authors": "Lim DS, Kim ST, Xu B, Maser RS, Lin J, Petrini JH, Kastan MB", "evidence": [ { "database": "Reactome", "id": "R-HSA-5693565", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5693565" } ], "reference": [ { "type": "PubMed", "id": "10766245", "url": "https://glygen.org/publication/PubMed/10766245" } ] }, { "title": "Immunolocalization of human p14(ARF) to the granular component of the interphase nucleolus.", "journal": "Experimental cell research", "date": "2000", "authors": "Lindstrom MS, Klangby U, Inoue R, Pisa P, Wiman KG, Asker CE", "evidence": [ { "database": "Reactome", "id": "R-HSA-2559580", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2559580" } ], "reference": [ { "type": "PubMed", "id": "10772813", "url": "https://glygen.org/publication/PubMed/10772813" } ] }, { "title": "Wild-type p53 transactivates the KILLER/DR5 gene through an intronic sequence-specific DNA-binding site.", "journal": "Oncogene", "date": "2000", "authors": "Takimoto R, El-Deiry WS", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803211", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803211" } ], "reference": [ { "type": "PubMed", "id": "10777207", "url": "https://glygen.org/publication/PubMed/10777207" } ] }, { "title": "Inactivation of p53 by human T-cell lymphotropic virus type 1 Tax requires activation of the NF-kappaB pathway and is dependent on p53 phosphorylation.", "journal": "Molecular and cellular biology", "date": "2000", "authors": "Pise-Masison CA, Mahieux R, Jiang H, Ashcroft M, Radonovich M, Duvall J, Guillerm C, Brady JN", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "10779327", "url": "https://glygen.org/publication/PubMed/10779327" } ] }, { "title": "ERKs and p38 kinase phosphorylate p53 protein at serine 15 in response to UV radiation.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "She QB, Chen N, Dong Z", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "10781582", "url": "https://glygen.org/publication/PubMed/10781582" } ] }, { "title": "How to activate p53.", "journal": "Current biology : CB", "date": "2000", "authors": "Caspari T", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "10801407", "url": "https://glygen.org/publication/PubMed/10801407" } ] }, { "title": "ATM-dependent phosphorylation of nibrin in response to radiation exposure.", "journal": "Nature genetics", "date": "2000", "authors": "Gatei M, Young D, Cerosaletti KM, Desai-Mehta A, Spring K, Kozlov S, Lavin MF, Gatti RA, Concannon P, Khanna K", "evidence": [ { "database": "Reactome", "id": "R-HSA-5693565", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5693565" } ], "reference": [ { "type": "PubMed", "id": "10802669", "url": "https://glygen.org/publication/PubMed/10802669" } ] }, { "title": "Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis.", "journal": "Science (New York, N.Y.)", "date": "2000", "authors": "Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803204", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803204" } ], "reference": [ { "type": "PubMed", "id": "10807576", "url": "https://glygen.org/publication/PubMed/10807576" } ] }, { "title": "A role for the p38 mitogen-acitvated protein kinase pathway in the transcriptional activation of p53 on genotoxic stress by chemotherapeutic agents.", "journal": "Cancer research", "date": "2000", "authors": "Sanchez-Prieto R, Rojas JM, Taya Y, Gutkind JS", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "10811125", "url": "https://glygen.org/publication/PubMed/10811125" } ] }, { "title": "The relationship between the gene mutation of p53 and the protein expression of p53 and Ki-67 in non-Hodgkin's lymphomas.", "journal": "Pathology international", "date": "1996", "authors": "Kuze T, Nakamura N, Hashimoto Y, Hojo H, Abe M, Wakasa H", "evidence": [ { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ { "type": "PubMed", "id": "10846560", "url": "https://glygen.org/publication/PubMed/10846560" } ] }, { "title": "A small synthetic peptide, which inhibits the p53-hdm2 interaction, stimulates the p53 pathway in tumour cell lines.", "journal": "Journal of molecular biology", "date": "2000", "authors": "Chene P, Fuchs J, Bohn J, Garcia-Echeverria C, Furet P, Fabbro D", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "10860736", "url": "https://glygen.org/publication/PubMed/10860736" } ] }, { "title": "ATM protein and p53-serine 15 phosphorylation in ataxia-telangiectasia (AT) patients and at heterozygotes.", "journal": "British journal of cancer", "date": "2000", "authors": "Delia D, Mizutani S, Panigone S, Tagliabue E, Fontanella E, Asada M, Yamada T, Taya Y, Prudente S, Saviozzi S, Frati L, Pierotti MA, Chessa L", "evidence": [ { "database": "iPTMnet", "id": "P04637-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637-1" } ], "reference": [ { "type": "PubMed", "id": "10864201", "url": "https://glygen.org/publication/PubMed/10864201" } ] }, { "title": "Role for ATM in DNA damage-induced phosphorylation of BRCA1.", "journal": "Cancer research", "date": "2000", "authors": "Gatei M, Scott SP, Filippovitch I, Soronika N, Lavin MF, Weber B, Khanna KK", "evidence": [ { "database": "Reactome", "id": "R-HSA-5693565", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5693565" } ], "reference": [ { "type": "PubMed", "id": "10866324", "url": "https://glygen.org/publication/PubMed/10866324" } ] }, { "title": "Signal transducer and activator of transcription 3 activates CCAAT enhancer-binding protein delta gene transcription in G0 growth-arrested mouse mammary epithelial cells and in involuting mouse mammary gland.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Hutt JA, O'Rourke JP, DeWille J", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "10867011", "url": "https://glygen.org/publication/PubMed/10867011" } ] }, { "title": "c-Jun inhibits transforming growth factor beta-mediated transcription by repressing Smad3 transcriptional activity.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Dennler S, Prunier C, Ferrand N, Gauthier JM, Atfi A", "evidence": [ { "database": "Reactome", "id": "R-HSA-2559580", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2559580" } ], "reference": [ { "type": "PubMed", "id": "10871633", "url": "https://glygen.org/publication/PubMed/10871633" } ] }, { "title": "The C-terminal regulatory domain of p53 contains a functional docking site for cyclin A.", "journal": "J. Mol. Biol.", "date": "2000", "authors": "Hupp T.R., Hutchins J.R.A., Luciani M.G., Zheleva D.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "Reactome", "id": "R-HSA-6804756", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804756" }, { "database": "iPTMnet", "id": "P04637-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637-1" } ], "reference": [ { "type": "PubMed", "id": "10884347", "url": "https://glygen.org/publication/PubMed/10884347" } ] }, { "title": "MCG10, a novel p53 target gene that encodes a KH domain RNA-binding protein, is capable of inducing apoptosis and cell cycle arrest in G(2)-M.", "journal": "Molecular and cellular biology", "date": "2000", "authors": "Zhu J, Chen X", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804116", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804116" } ], "reference": [ { "type": "PubMed", "id": "10891498", "url": "https://glygen.org/publication/PubMed/10891498" } ] }, { "title": "Human p53 is phosphorylated on serines 6 and 9 in response to DNA damage-inducing agents.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Higashimoto Y, Saito S, Tong XH, Hong A, Sakaguchi K, Appella E, Anderson CW", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "10930428", "url": "https://glygen.org/publication/PubMed/10930428" } ] }, { "title": "Phosphorylation of human p53 on Thr-55.", "journal": "Biochemistry", "date": "2000", "authors": "Gatti A, Li HH, Traugh JA, Liu X", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "10933801", "url": "https://glygen.org/publication/PubMed/10933801" } ] }, { "title": "The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein.", "journal": "Oncogene", "date": "2000", "authors": "Lazo P.A., Lopez-Borges S.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "iPTMnet", "id": "P04637-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637-1" } ], "reference": [ { "type": "PubMed", "id": "10951572", "url": "https://glygen.org/publication/PubMed/10951572" } ] }, { "title": "A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage.", "journal": "Current biology : CB", "date": "2000", "authors": "Paull TT, Rogakou EP, Yamazaki V, Kirchgessner CU, Gellert M, Bonner WM", "evidence": [ { "database": "Reactome", "id": "R-HSA-5693565", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5693565" } ], "reference": [ { "type": "PubMed", "id": "10959836", "url": "https://glygen.org/publication/PubMed/10959836" } ] }, { "title": "Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis.", "journal": "Nature genetics", "date": "2000", "authors": "Lin Y, Ma W, Benchimol S", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803207" } ], "reference": [ { "type": "PubMed", "id": "10973264", "url": "https://glygen.org/publication/PubMed/10973264" } ] }, { "title": "Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2000", "authors": "Matsuoka S, Rotman G, Ogawa A, Shiloh Y, Tamai K, Elledge SJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-5693565", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5693565" } ], "reference": [ { "type": "PubMed", "id": "10973490", "url": "https://glygen.org/publication/PubMed/10973490" } ] }, { "title": "A ribonucleotide reductase gene is a transcriptional target of p53 and p73.", "journal": "Oncogene", "date": "2000", "authors": "Nakano K, Balint E, Ashcroft M, Vousden KH", "evidence": [ { "database": "Reactome", "id": "R-HSA-5628897", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5628897" } ], "reference": [ { "type": "PubMed", "id": "10980602", "url": "https://glygen.org/publication/PubMed/10980602" } ] }, { "title": "An intact HDM2 RING-finger domain is required for nuclear exclusion of p53.", "journal": "Nature cell biology", "date": "2000", "authors": "Boyd SD, Tsai KY, Jacks T", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804757", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804757" } ], "reference": [ { "type": "PubMed", "id": "10980695", "url": "https://glygen.org/publication/PubMed/10980695" } ] }, { "title": "The MDM2 RING-finger domain is required to promote p53 nuclear export.", "journal": "Nature cell biology", "date": "2000", "authors": "Geyer RK, Yu ZK, Maki CG", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804757", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804757" } ], "reference": [ { "type": "PubMed", "id": "10980696", "url": "https://glygen.org/publication/PubMed/10980696" } ] }, { "title": "A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Kato M, Miyazawa K, Kitamura N", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "10982817", "url": "https://glygen.org/publication/PubMed/10982817" } ] }, { "title": "p53 and c-Jun functionally synergize in the regulation of the DNA repair gene hMSH2 in response to UV.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Scherer SJ, Maier SM, Seifert M, Hanselmann RG, Zang KD, Muller-Hermelink HK, Angel P, Welter C, Schartl M", "evidence": [ { "database": "Reactome", "id": "R-HSA-6796648", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6796648" } ], "reference": [ { "type": "PubMed", "id": "10984493", "url": "https://glygen.org/publication/PubMed/10984493" } ] }, { "title": "TP53 mutations and MDM2 gene amplification in squamous-cell carcinomas of the esophagus in south Thailand.", "journal": "International journal of cancer", "date": "2000", "authors": "Taniere P, Martel-Planche G, Puttawibul P, Casson A, Montesano R, Chanvitan A, Hainaut P", "evidence": [ { "database": "dbSNP", "id": "rs1057519986", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1057519986" } ], "reference": [ { "type": "PubMed", "id": "11004672", "url": "https://glygen.org/publication/PubMed/11004672" } ] }, { "title": "Aberrant regulation and function of wild-type p53 in radioresistant melanoma cells.", "journal": "Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research", "date": "2000", "authors": "Satyamoorthy K, Chehab NH, Waterman MJ, Lien MC, El-Deiry WS, Herlyn M, Halazonetis TD", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "11007451", "url": "https://glygen.org/publication/PubMed/11007451" } ] }, { "title": "p53 amino acids 339-346 represent the minimal p53 repression domain.", "journal": "J. Biol. Chem.", "date": "2001", "authors": "Yang P.C., Chen J.J., Hong T.M., Peck K., Wu C.W.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "11007800", "url": "https://glygen.org/publication/PubMed/11007800" } ] }, { "title": "Human TP53 from the malignant glioma-derived cell lines M059J and M059K has a cancer-associated mutation in exon 8.", "journal": "Radiat. Res.", "date": "2000", "authors": "Anderson C.W., Allalunis-Turner M.J.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "11023613", "url": "https://glygen.org/publication/PubMed/11023613" } ] }, { "title": "The function of PML in p53-dependent apoptosis.", "journal": "Nat. Cell Biol.", "date": "2000", "authors": "Gu W., Luo J., Guo A., Zhong S., Pandolfi P.P., Salomoni P., Shih A.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "11025664", "url": "https://glygen.org/publication/PubMed/11025664" } ] }, { "title": "Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1.", "journal": "Nature cell biology", "date": "2000", "authors": "Melchionna R, Chen XB, Blasina A, McGowan CH", "evidence": [ { "database": "Reactome", "id": "R-HSA-5693565", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5693565" } ], "reference": [ { "type": "PubMed", "id": "11025670", "url": "https://glygen.org/publication/PubMed/11025670" } ] }, { "title": "Overexpression of fructose 2,6-bisphosphatase decreases glycolysis and delays cell cycle progression.", "journal": "American journal of physiology. Cell physiology", "date": "2000", "authors": "Perez JX, Roig T, Manzano A, Dalmau M, Boada J, Ventura F, Rosa JL, Bermudez J, Bartrons R", "evidence": [ { "database": "Reactome", "id": "R-HSA-5628897", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5628897" } ], "reference": [ { "type": "PubMed", "id": "11029283", "url": "https://glygen.org/publication/PubMed/11029283" } ] }, { "title": "p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53.", "journal": "Cell", "date": "2000", "authors": "Oda K, Arakawa H, Tanaka T, Matsuda K, Tanikawa C, Mori T, Nishimori H, Tamai K, Tokino T, Nakamura Y, Taya Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803204", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803204" }, { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "11030628", "url": "https://glygen.org/publication/PubMed/11030628" } ] }, { "title": "Thermodynamics of p53 binding to hdm2(1-126): effects of phosphorylation and p53 peptide length.", "journal": "Archives of biochemistry and biophysics", "date": "2000", "authors": "Lai Z, Auger KR, Manubay CM, Copeland RA", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "11032416", "url": "https://glygen.org/publication/PubMed/11032416" } ] }, { "title": "Cells overexpressing fructose-2,6-bisphosphatase showed enhanced pentose phosphate pathway flux and resistance to oxidative stress.", "journal": "FEBS letters", "date": "2000", "authors": "Boada J, Roig T, Perez X, Gamez A, Bartrons R, Cascante M, Bermudez J", "evidence": [ { "database": "Reactome", "id": "R-HSA-5628897", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5628897" } ], "reference": [ { "type": "PubMed", "id": "11034341", "url": "https://glygen.org/publication/PubMed/11034341" } ] }, { "title": "Multitasking in signal transduction by a promiscuous human Ins(3,4,5,6)P(4) 1-kinase/Ins(1,3,4)P(3) 5/6-kinase.", "journal": "The Biochemical journal", "date": "2000", "authors": "Yang X, Shears SB", "evidence": [ { "database": "Reactome", "id": "R-HSA-983231", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983231" } ], "reference": [ { "type": "PubMed", "id": "11042108", "url": "https://glygen.org/publication/PubMed/11042108" } ] }, { "title": "A serine 37 mutation associated with two missense mutations at highly conserved regions of p53 affect pro-apoptotic genes expression in a T-lymphoblastoid drug resistant cell line.", "journal": "Oncogene", "date": "2000", "authors": "Cinti C, Claudio PP, Luca AD, Cuccurese M, Howard CM, D'Esposito M, Paggi MG, Sala DL, Azzoni L, Halazonetis TD, Giordano A, Maraldi NM", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "11042698", "url": "https://glygen.org/publication/PubMed/11042698" } ] }, { "title": "Prognostic significance of TP53 gene mutation in 995 cases of colorectal carcinoma. Influence of tumour site, stage, adjuvant chemotherapy and type of mutation.", "journal": "European journal of cancer (Oxford, England : 1990)", "date": "2000", "authors": "Soong R, Powell B, Elsaleh H, Gnanasampanthan G, Smith DR, Goh HS, Joseph D, Iacopetta B", "evidence": [ { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ { "type": "PubMed", "id": "11044641", "url": "https://glygen.org/publication/PubMed/11044641" } ] }, { "title": "Genomic aberrations in human hepatocellular carcinomas of differing etiologies.", "journal": "Clinical cancer research : an official journal of the American Association for Cancer Research", "date": "2000", "authors": "Wong N, Lai P, Pang E, Fung LF, Sheng Z, Wong V, Wang W, Hayashi Y, Perlman E, Yuna S, Lau JW, Johnson PJ", "evidence": [ { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ { "type": "PubMed", "id": "11051249", "url": "https://glygen.org/publication/PubMed/11051249" } ] }, { "title": "Bcl-G, a novel pro-apoptotic member of the Bcl-2 family.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Guo B, Godzik A, Reed JC", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803205", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803205" } ], "reference": [ { "type": "PubMed", "id": "11054413", "url": "https://glygen.org/publication/PubMed/11054413" } ] }, { "title": "Characterization of IL-4 and IL-13 signals dependent on the human IL-13 receptor alpha chain 1: redundancy of requirement of tyrosine residue for STAT3 activation.", "journal": "International immunology", "date": "2000", "authors": "Umeshita-Suyama R, Sugimoto R, Akaiwa M, Arima K, Yu B, Wada M, Kuwano M, Nakajima K, Hamasaki N, Izuhara K", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "11058569", "url": "https://glygen.org/publication/PubMed/11058569" } ] }, { "title": "Hyaluronidase induction of a WW domain-containing oxidoreductase that enhances tumor necrosis factor cytotoxicity.", "journal": "J. Biol. Chem.", "date": "2001", "authors": "Chang N.-S., Schultz L., Pratt N., Carey G.B., Heath J., Sleve D., Zevotek N.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "11058590", "url": "https://glygen.org/publication/PubMed/11058590" } ] }, { "title": "Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain.", "journal": "The Journal of cell biology", "date": "2000", "authors": "Nielsen E, Christoforidis S, Uttenweiler-Joseph S, Miaczynska M, Dewitte F, Wilm M, Hoflack B, Zerial M", "evidence": [ { "database": "Reactome", "id": "R-HSA-983231", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983231" } ], "reference": [ { "type": "PubMed", "id": "11062261", "url": "https://glygen.org/publication/PubMed/11062261" } ] }, { "title": "Stoichiometric phosphorylation of human p53 at Ser315 stimulates p53-dependent transcription.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Blaydes JP, Luciani MG, Pospisilova S, Ball HM, Vojtesek B, Hupp TR", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "11078726", "url": "https://glygen.org/publication/PubMed/11078726" } ] }, { "title": "Insights into the molecular mechanism of p53 inhibition by HTLV type 1 Tax.", "journal": "AIDS research and human retroviruses", "date": "2000", "authors": "Pise-Masison CA, Mahieux R, Radonovich M, Jiang H, Duvall J, Guillerm C, Brady JN", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "11080808", "url": "https://glygen.org/publication/PubMed/11080808" } ] }, { "title": "A stat-responsive element in the promoter of the episialin/MUC1 gene is involved in its overexpression in carcinoma cells.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Gaemers IC, Vos HL, Volders HH, van der Valk SW, Hilkens J", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "11084045", "url": "https://glygen.org/publication/PubMed/11084045" } ] }, { "title": "The plant isoflavenoid genistein activates p53 and Chk2 in an ATM-dependent manner.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Ye R, Bodero A, Zhou BB, Khanna KK, Lavin MF, Lees-Miller SP", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "11096068", "url": "https://glygen.org/publication/PubMed/11096068" } ] }, { "title": "Deacetylation of p53 modulates its effect on cell growth and apoptosis.", "journal": "Nature", "date": "2000", "authors": "Luo J, Su F, Chen D, Shiloh A, Gu W", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804758", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804758" } ], "reference": [ { "type": "PubMed", "id": "11099047", "url": "https://glygen.org/publication/PubMed/11099047" } ] }, { "title": "HIV induces lymphocyte apoptosis by a p53-initiated, mitochondrial-mediated mechanism.", "journal": "FASEB journal : official publication of the Federation of American Societies for Experimental Biology", "date": "2001", "authors": "Genini D, Sheeter D, Rought S, Zaunders JJ, Susin SA, Kroemer G, Richman DD, Carson DA, Corbeil J, Leoni LM", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "11099484", "url": "https://glygen.org/publication/PubMed/11099484" } ] }, { "title": "Arsenite induces p53 accumulation through an ATM-dependent pathway in human fibroblasts.", "journal": "Cancer research", "date": "2000", "authors": "Yih LH, Lee TC", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "11103796", "url": "https://glygen.org/publication/PubMed/11103796" } ] }, { "title": "Direct regulation of pituitary proopiomelanocortin by STAT3 provides a novel mechanism for immuno-neuroendocrine interfacing.", "journal": "The Journal of clinical investigation", "date": "2000", "authors": "Bousquet C, Zatelli MC, Melmed S", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "11104795", "url": "https://glygen.org/publication/PubMed/11104795" } ] }, { "title": "Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress.", "journal": "Genes & development", "date": "2000", "authors": "Tibbetts RS, Cortez D, Brumbaugh KM, Scully R, Livingston D, Elledge SJ, Abraham RT", "evidence": [ { "database": "Reactome", "id": "R-HSA-5693565", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5693565" } ], "reference": [ { "type": "PubMed", "id": "11114888", "url": "https://glygen.org/publication/PubMed/11114888" } ] }, { "title": "Suppression of signal transducer and activator of transcription 3-dependent B lymphocyte terminal differentiation by BCL-6.", "journal": "The Journal of experimental medicine", "date": "2000", "authors": "Reljic R, Wagner SD, Peakman LJ, Fearon DT", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "11120780", "url": "https://glygen.org/publication/PubMed/11120780" } ] }, { "title": "Radiation-induced senescence-like growth arrest requires TP53 function but not telomere shortening.", "journal": "Radiation research", "date": "2001", "authors": "Suzuki K, Mori I, Nakayama Y, Miyakoda M, Kodama S, Watanabe M", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "11121242", "url": "https://glygen.org/publication/PubMed/11121242" } ] }, { "title": "SUMO-1 conjugation in vivo requires both a consensus modification motif and nuclear targeting.", "journal": "J. Biol. Chem.", "date": "2001", "authors": "Hay R.T., Rodriguez M.S., Dargemont C.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "11124955", "url": "https://glygen.org/publication/PubMed/11124955" } ] }, { "title": "Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from alpha -particle irradiated to nonirradiated cells.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2001", "authors": "Azzam EI, de Toledo SM, Little JB", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "11149936", "url": "https://glygen.org/publication/PubMed/11149936" } ] }, { "title": "Enhancement of the antiproliferative function of p53 by phosphorylation at serine 20: an inference from site-directed mutagenesis studies.", "journal": "International journal of molecular medicine", "date": "2001", "authors": "Jabbur JR, Huang P, Zhang W", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "11172619", "url": "https://glygen.org/publication/PubMed/11172619" } ] }, { "title": "DNA damage-induced phosphorylation of p53 at serine 20 correlates with p21 and Mdm-2 induction in vivo.", "journal": "Oncogene", "date": "2000", "authors": "Jabbur JR, Huang P, Zhang W", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "11175334", "url": "https://glygen.org/publication/PubMed/11175334" } ] }, { "title": "Significance of p53 mutations in patients with chronic lymphocytic leukemia: a sequential study of 30 patients.", "journal": "Cancer", "date": "2001", "authors": "Barnabas N, Shurafa M, Van Dyke DL, Wolman SR, Clark D, Worsham MJ", "evidence": [ { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ { "type": "PubMed", "id": "11180073", "url": "https://glygen.org/publication/PubMed/11180073" } ] }, { "title": "Genetic aberration in primary hepatocellular carcinoma: correlation between p53 gene mutation and loss-of-heterozygosity on chromosome 16q21-q23 and 9p21-p23.", "journal": "Cell research", "date": "2000", "authors": "Wang G, Huang CH, Zhao Y, Cai L, Wang Y, Xiu SJ, Jiang ZW, Yang S, Zhao T, Huang W, Gu JR", "evidence": [ { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ { "type": "PubMed", "id": "11191353", "url": "https://glygen.org/publication/PubMed/11191353" } ] }, { "title": "Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence.", "journal": "Nature", "date": "2001", "authors": "Ohtani N, Zebedee Z, Huot TJ, Stinson JA, Sugimoto M, Ohashi Y, Sharrocks AD, Peters G, Hara E", "evidence": [ { "database": "Reactome", "id": "R-HSA-2559585", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2559585" } ], "reference": [ { "type": "PubMed", "id": "11234019", "url": "https://glygen.org/publication/PubMed/11234019" } ] }, { "title": "A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1.", "journal": "Mol. Cell", "date": "2001", "authors": "Shu H., Wang Y., Zhao Y., Lu H., Zhang Q.H., Zeng X., Goodman R., Kapoor M., Keller D.M., Lozano G.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "Reactome", "id": "R-HSA-6804756", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804756" }, { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "11239457", "url": "https://glygen.org/publication/PubMed/11239457" } ] }, { "title": "Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.", "journal": "Nature", "date": "2001", "authors": "Lachner M, O'Carroll D, Rea S, Mechtler K, Jenuwein T", "evidence": [ { "database": "Reactome", "id": "R-HSA-983231", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983231" } ], "reference": [ { "type": "PubMed", "id": "11242053", "url": 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activation of human caspase-1 by tumor suppressor p53.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Gupta S, Radha V, Furukawa Y, Swarup G", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803207" } ], "reference": [ { "type": "PubMed", "id": "11278253", "url": "https://glygen.org/publication/PubMed/11278253" } ] }, { "title": "Thrombin regulates vascular smooth muscle cell growth and heat shock proteins via the JAK-STAT pathway.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Madamanchi NR, Li S, Patterson C, Runge MS", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "11278437", "url": "https://glygen.org/publication/PubMed/11278437" } ] }, { "title": "Co-operative effect of c-Src tyrosine kinase and Stat3 in activation of hepatocyte growth factor expression in mammary carcinoma cells.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Hung W, Elliott B", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "11278729", "url": "https://glygen.org/publication/PubMed/11278729" } ] }, { "title": "p53-dependent transcriptional regulation of the APC promoter in colon cancer cells treated with DNA alkylating agents.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Jaiswal AS, Narayan S", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "11279192", "url": "https://glygen.org/publication/PubMed/11279192" } ] }, { "title": "Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress.", "journal": "Molecular and cellular biology", "date": "2001", "authors": "Buschmann T, Potapova O, Bar-Shira A, Ivanov VN, Fuchs SY, Henderson S, Fried VA, Minamoto T, Alarcon-Vargas D, Pincus MR, Gaarde WA, Holbrook NJ, Shiloh Y, Ronai Z", "evidence": [ { "database": "iPTMnet", "id": "P04637-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637-1" } ], "reference": [ { "type": "PubMed", "id": "11283254", "url": "https://glygen.org/publication/PubMed/11283254" } ] }, { "title": "COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system.", "journal": "The EMBO journal", "date": "2001", "authors": "Bech-Otschir D, Kraft R, Huang X, Henklein P, Kapelari B, Pollmann C, Dubiel W", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "11285227", "url": 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"evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "11300786", "url": "https://glygen.org/publication/PubMed/11300786" } ] }, { "title": "Cadmium induces phosphorylation of p53 at serine 15 in MCF-7 cells.", "journal": "Biochemical and biophysical research communications", "date": "2001", "authors": "Matsuoka M, Igisu H", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "11302731", "url": "https://glygen.org/publication/PubMed/11302731" } ] }, { "title": "Ataxia-telangiectasia: chronic activation of damage-responsive functions is reduced by alpha-lipoic acid.", "journal": "Oncogene", "date": "2001", "authors": "Gatei M, Shkedy D, Khanna KK, Uziel T, Shiloh Y, Pandita TK, Lavin MF, Rotman G", "evidence": [ { "database": "iPTMnet", "id": "P04637", 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"url": "https://glygen.org/publication/PubMed/11390408" } ] }, { "title": "A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylation.", "journal": "Science (New York, N.Y.)", "date": "2001", "authors": "Zhang Y, Xiong Y", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "11397945", "url": "https://glygen.org/publication/PubMed/11397945" } ] }, { "title": "Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2001", "authors": "Bowman T, Broome MA, Sinibaldi D, Wharton W, Pledger WJ, Sedivy JM, Irby R, Yeatman T, Courtneidge SA, Jove R", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": 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Biol. Chem.", "date": "2001", "authors": "Wang Q., Wu H., Lu L., Dai W., Xie S., Jhanwar-Uniyal M., Cogswell J.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "Reactome", "id": "R-HSA-6804756", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804756" }, { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "11447225", "url": "https://glygen.org/publication/PubMed/11447225" } ] }, { "title": "Nuclear retention of ATM at sites of DNA double strand breaks.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Andegeko Y, Moyal L, Mittelman L, Tsarfaty I, Shiloh Y, Rotman G", "evidence": [ { "database": "Reactome", "id": "R-HSA-2559586", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2559586" } ], "reference": [ { "type": "PubMed", "id": "11454856", "url": "https://glygen.org/publication/PubMed/11454856" } ] }, { "title": "Isolation and characterization of two novel A20-like proteins.", "journal": "The Biochemical journal", "date": "2001", "authors": "Evans PC, Taylor ER, Coadwell J, Heyninck K, Beyaert R, Kilshaw PJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689896", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689896" } ], "reference": [ { "type": "PubMed", "id": "11463333", "url": "https://glygen.org/publication/PubMed/11463333" } ] }, { "title": "Cooperation between STAT3 and c-jun suppresses Fas transcription.", "journal": "Molecular cell", "date": "2001", "authors": "Ivanov VN, Bhoumik A, Krasilnikov M, Raz R, Owen-Schaub LB, Levy D, Horvath CM, Ronai Z", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "11463377", "url": "https://glygen.org/publication/PubMed/11463377" } ] }, { "title": "PUMA, a novel proapoptotic gene, is induced by p53.", "journal": "Molecular cell", "date": "2001", "authors": "Nakano K, Vousden KH", "evidence": [ { "database": "Reactome", "id": "R-HSA-139915", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-139915" } ], "reference": [ { "type": "PubMed", "id": "11463392", "url": "https://glygen.org/publication/PubMed/11463392" } ] }, { "title": "An inherited p53 mutation that contributes in a tissue-specific manner to pediatric adrenal cortical carcinoma.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2001", "authors": "Sandrini R., Stratakis C.A., Zambetti G.P., Cadwell C., Cat I., DeLacerda L., Figueiredo B., Lafferty A.R., Michalkiewicz E., Rabin M., Ribeiro R.C., Sampaio G., Sandrini F.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "11481490", "url": "https://glygen.org/publication/PubMed/11481490" } ] }, { "title": "Glycogen synthase kinase3 beta phosphorylates serine 33 of p53 and activates p53's transcriptional activity.", "journal": "BMC cell biology", "date": "2001", "authors": "Turenne GA, Price BD", "evidence": [ { "database": "iPTMnet", "id": "P04637-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637-1" } ], "reference": [ { "type": "PubMed", "id": "11483158", "url": "https://glygen.org/publication/PubMed/11483158" } ] }, { "title": "Growth factors can influence cell growth and survival through effects on glucose metabolism.", "journal": "Molecular and cellular biology", "date": "2001", "authors": "Vander Heiden MG, Plas DR, Rathmell JC, Fox CJ, Harris MH, Thompson CB", "evidence": [ { "database": "Reactome", "id": "R-HSA-5628897", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5628897" } ], "reference": [ { "type": "PubMed", "id": "11486029", "url": "https://glygen.org/publication/PubMed/11486029" } ] }, { "title": "DNA alkylation-induced phosphorylation of p53 and activation of kinases in colon cancer cells.", "journal": "International journal of oncology", "date": "2001", "authors": "Jaiswal AS, Narayan S", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "11494044", "url": "https://glygen.org/publication/PubMed/11494044" } ] }, { "title": "Osmotic shock induces G1 arrest through p53 phosphorylation at Ser33 by activated p38MAPK without phosphorylation at Ser15 and Ser20.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Kishi H, Nakagawa K, Matsumoto M, Suga M, Ando M, Taya Y, Yamaizumi M", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "11495913", "url": "https://glygen.org/publication/PubMed/11495913" } ] }, { "title": "A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2001", "authors": "Mayo LD, Donner DB", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804757", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804757" } ], "reference": [ { "type": "PubMed", "id": "11504915", "url": "https://glygen.org/publication/PubMed/11504915" } ] }, { "title": "New monoclonal antibodies recognizing p53 protein phosphorylated by casein kinase II at serine 392.", "journal": "Folia biologica", "date": "2001", "authors": "Pospisilova S, Kankova K, Svitakova M, Nenutil R, Vojtesek B", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "11508859", "url": "https://glygen.org/publication/PubMed/11508859" } ] }, { "title": "A TPR motif cofactor contributes to p300 activity in the p53 response.", "journal": "Molecular cell", "date": "2001", "authors": "Demonacos C, Krstic-Demonacos M, La Thangue NB", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804760", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804760" } ], "reference": [ { "type": "PubMed", "id": "11511361", "url": "https://glygen.org/publication/PubMed/11511361" } ] }, { "title": "p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis.", "journal": "Molecular cell", "date": "2001", "authors": "Okamura S, Arakawa H, Tanaka 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"2001", "authors": "Stambolic V, MacPherson D, Sas D, Lin Y, Snow B, Jang Y, Benchimol S, Mak TW", "evidence": [ { "database": "Reactome", "id": "R-HSA-5628897", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5628897" } ], "reference": [ { "type": "PubMed", "id": "11545734", "url": "https://glygen.org/publication/PubMed/11545734" } ] }, { "title": "Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, and the testes.", "journal": "J. Biol. Chem.", "date": "2001", "authors": "Wei S., Matsumoto S., Nikawa J., Abe Y., Ueda N., Nezu K., Kito K., Shigemoto K., Enomoto Y., Hitsumoto Y., Miyoshi A.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "Reactome", "id": "R-HSA-6804756", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804756" } ], "reference": [ { "type": "PubMed", "id": "11546806", "url": "https://glygen.org/publication/PubMed/11546806" } ] }, { "title": "Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway.", "journal": "J. Biol. Chem.", "date": "2001", "authors": "Wang Q., Wu H., Dai W., Xie S., Husain I., Jhanwar-Uniyal M., Cogswell J.P., Conn C., Stambrook P.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "Reactome", "id": "R-HSA-6804756", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804756" }, { "database": "iPTMnet", "id": "P04637-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637-1" } ], "reference": [ { "type": "PubMed", "id": "11551930", "url": "https://glygen.org/publication/PubMed/11551930" } ] }, { "title": "Zinc binding and redox control of p53 structure and function.", "journal": "Antioxid. 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Cell Biol.", "date": "2002", "authors": "Zentgraf H., Taya Y., Moeller A., Hofmann T.G., Will H., Schmitz M.L., Droege W., Sirma H.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "Reactome", "id": "R-HSA-6804756", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804756" }, { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "11740489", "url": "https://glygen.org/publication/PubMed/11740489" } ] }, { "title": "Camptothecin and Zeocin can increase p53 levels during all cell cycle stages.", "journal": "Biochemical and biophysical research communications", "date": "2001", "authors": "Houser S, Koshlatyi S, Lu T, Gopen T, Bargonetti J", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "11741290", "url": "https://glygen.org/publication/PubMed/11741290" } ] }, { "title": "RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Miller KA, Yoshikawa DM, McConnell IR, Clark R, Schild D, Albala JS", "evidence": [ { "database": "Reactome", "id": "R-HSA-983231", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983231" } ], "reference": [ { "type": "PubMed", "id": "11744692", "url": "https://glygen.org/publication/PubMed/11744692" } ] }, { "title": "Interaction of p53 and DNA-PK in response to nucleoside analogues: potential role as a sensor complex for DNA damage.", "journal": "Cancer research", "date": "2001", "authors": "Achanta G, Pelicano H, Feng L, Plunkett W, Huang P", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "11751391", "url": "https://glygen.org/publication/PubMed/11751391" } ] }, { "title": "Mediator function of the human Rad51B-Rad51C complex in Rad51/RPA-catalyzed DNA strand exchange.", "journal": "Genes & development", "date": "2001", "authors": "Sigurdsson S, Van Komen S, Bussen W, Schild D, Albala JS, Sung P", "evidence": [ { "database": "Reactome", "id": "R-HSA-983231", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983231" } ], "reference": [ { "type": "PubMed", "id": "11751636", "url": "https://glygen.org/publication/PubMed/11751636" } ] }, { "title": "A novel mechanism of tumorigenesis involving pH-dependent destabilization of a mutant p53 tetramer.", "journal": "Nature structural biology", "date": "2002", "authors": "DiGiammarino EL, Lee AS, Cadwell C, Zhang W, Bothner B, Ribeiro RC, Zambetti G, Kriwacki RW", "evidence": [ { "database": "Reactome", "id": "R-HSA-9723905", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9723905" }, { "database": "Entrez", "id": "7157", "url": "https://www.ncbi.nlm.nih.gov/gene/7157" } ], "reference": [ { "type": "PubMed", "id": "11753428", "url": "https://glygen.org/publication/PubMed/11753428" } ] }, { "title": "p53 mutation, EGFR gene amplification and loss of heterozygosity on chromosome 10, 17 p in human gliomas.", "journal": "Chinese medical journal", "date": "2000", "authors": "Jin W, Xu X, Yang T, Hua Z", "evidence": [ { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ { "type": "PubMed", "id": "11776043", "url": "https://glygen.org/publication/PubMed/11776043" } ] }, { "title": "Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.", "journal": "Nat. Cell Biol.", "date": "2002", "authors": "Appella E., Saito S., Bruno T., Fanciulli M., Soddu S., Del Sal G., Higashimoto Y., Manni I., Piaggio G., Gostissa M., Marchetti A., D'Orazi G., Cecchinelli B., Coen S.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "Reactome", "id": "R-HSA-6804756", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804756" }, { "database": "iPTMnet", "id": "P04637-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637-1" } ], "reference": [ { "type": "PubMed", "id": "11780126", "url": "https://glygen.org/publication/PubMed/11780126" } ] }, { "title": "The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling.", "journal": "Nature cell biology", "date": "2001", "authors": "Virolle T, Adamson ED, Baron V, Birle D, Mercola D, Mustelin T, de Belle I", "evidence": [ { "database": "Reactome", "id": "R-HSA-8943724", "url": 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and the coactivator Zac-1.", "journal": "Oncogene", "date": "2002", "authors": "Rozenfeld-Granot G, Krishnamurthy J, Kannan K, Toren A, Amariglio N, Givol D, Rechavi G", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804115", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804115" } ], "reference": [ { "type": "PubMed", "id": "11896574", "url": "https://glygen.org/publication/PubMed/11896574" } ] }, { "title": "Role of MAP kinases in UVB-induced phosphorylation of p53 at serine 20.", "journal": "Oncogene", "date": "2002", "authors": "She QB, Ma WY, Dong Z", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "11896587", "url": "https://glygen.org/publication/PubMed/11896587" } ] }, { "title": "A polymorphic microsatellite that mediates induction of PIG3 by p53.", "journal": "Nature genetics", "date": "2002", "authors": "Contente A, Dittmer A, Koch MC, Roth J, Dobbelstein M", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803205", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803205" } ], "reference": [ { "type": "PubMed", "id": "11919562", "url": "https://glygen.org/publication/PubMed/11919562" } ] }, { "title": "TP53 genotype but not p53 immunohistochemical result predicts response to preoperative short-term radiotherapy in rectal cancer.", "journal": "Annals of surgery", "date": "2002", "authors": "Kandioler D, Zwrtek R, Ludwig C, Janschek E, Ploner M, Hofbauer F, Kuhrer I, Kappel S, Wrba F, Horvath M, Karner J, Renner K, Bergmann M, Karner-Hanusch J, Potter R, Jakesz R, Teleky B, Herbst F", "evidence": [ { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ { "type": "PubMed", "id": "11923604", "url": "https://glygen.org/publication/PubMed/11923604" } ] }, { "title": "Deubiquitination of p53 by HAUSP is an important pathway for 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Biol. Chem.", "date": "2002", "authors": "Kim E.-J., Um S.-J., Park J.-S.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "11925430", "url": "https://glygen.org/publication/PubMed/11925430" } ] }, { "title": "Cellular responses to the DNA strand-scission enediyne C-1027 can be independent of ATM, ATR, and DNA-PK kinases.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Dziegielewski J, Beerman TA", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "11927575", "url": "https://glygen.org/publication/PubMed/11927575" } ] }, { "title": "Autoubiquitination of the BRCA1*BARD1 RING ubiquitin ligase.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Chen A, Kleiman FE, Manley JL, Ouchi T, Pan ZQ", "evidence": [ { 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mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo.", "journal": "Journal of cell science", "date": "2002", "authors": "Rojo M, Legros F, Chateau D, Lombes A", "evidence": [ { "database": "Reactome", "id": "R-HSA-983231", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983231" } ], "reference": [ { "type": "PubMed", "id": "11950885", "url": "https://glygen.org/publication/PubMed/11950885" } ] }, { "title": "p53 regulates cell survival by inhibiting PIK3CA in squamous cell carcinomas.", "journal": "Genes & development", "date": "2002", "authors": "Singh B, Reddy PG, Goberdhan A, Walsh C, Dao S, Ngai I, Chou TC, O-Charoenrat P, Levine AJ, Rao PH, Stoffel A", "evidence": [ { "database": "Reactome", "id": "R-HSA-5628897", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5628897" } ], "reference": [ { "type": "PubMed", "id": "11959846", "url": "https://glygen.org/publication/PubMed/11959846" } ] }, { "title": "Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis.", "journal": "Oncogene", "date": "2002", "authors": "Niu G, Wright KL, Huang M, Song L, Haura E, Turkson J, Zhang S, Wang T, Sinibaldi D, Coppola D, Heller R, Ellis LM, Karras J, Bromberg J, Pardoll D, Jove R, Yu H", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "11960372", "url": "https://glygen.org/publication/PubMed/11960372" } ] }, { "title": "Glycerol restores heat-induced p53-dependent apoptosis of human glioblastoma cells bearing mutant p53.", "journal": "BMC biotechnology", "date": "2002", "authors": "Ohnishi T, Ohnishi K, Takahashi A", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "11965244", "url": "https://glygen.org/publication/PubMed/11965244" } ] }, { "title": "p53 Binds and activates the xeroderma pigmentosum DDB2 gene in humans but not mice.", "journal": "Molecular and cellular biology", "date": "2002", "authors": "Tan T, Chu G", "evidence": [ { "database": "Reactome", "id": "R-HSA-6796648", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6796648" } ], "reference": [ { "type": "PubMed", "id": "11971958", "url": "https://glygen.org/publication/PubMed/11971958" } ] }, { "title": "Accumulation of an inactive form of p53 protein in cells treated with TNF alpha.", "journal": "Cell death and differentiation", "date": "2002", "authors": "Drane P, Leblanc V, Miro-Mur F, Saffroy R, Debuire B, May E", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "11973611", "url": "https://glygen.org/publication/PubMed/11973611" } ] }, { "title": "Carcinogen-specific mutation pattern in the p53 tumour suppressor gene in UV radiation-induced basal cell carcinoma.", "journal": "International archives of occupational and environmental health", "date": "2002", "authors": "Weihrauch M, Bader M, Lehnert G, Wittekind C, Tannapfel A, Wrbitzky R", "evidence": [ { "database": "dbSNP", "id": "rs587782329", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs587782329" } ], "reference": [ { "type": "PubMed", "id": "11981662", "url": "https://glygen.org/publication/PubMed/11981662" } ] }, { "title": "Cyclin G recruits PP2A to dephosphorylate Mdm2.", "journal": "Molecular cell", "date": "2002", "authors": "Okamoto K, Li H, Jensen MR, Zhang T, Taya Y, Thorgeirsson SS, Prives C", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804757", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804757" } ], "reference": [ { "type": "PubMed", "id": "11983168", "url": "https://glygen.org/publication/PubMed/11983168" } ] }, { "title": "Cyclin K as a direct transcriptional target of the p53 tumor suppressor.", "journal": "Neoplasia (New York, N.Y.)", "date": "2002", "authors": "Mori T, Anazawa Y, Matsui K, Fukuda S, Nakamura Y, Arakawa H", "evidence": [ { "database": "Reactome", "id": "R-HSA-6796648", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6796648" } ], "reference": [ { "type": "PubMed", "id": "11988847", "url": "https://glygen.org/publication/PubMed/11988847" } ] }, { "title": "Topoisomerase IIalpha gene expression is regulated by the p53 tumor suppressor gene in nonsmall cell lung carcinoma patients.", "journal": "Cancer", "date": "2002", "authors": "Liu D, Huang CL, Kameyama K, Hayashi E, Yamauchi A, Sumitomo S, Yokomise H", "evidence": [ { "database": "dbSNP", "id": "rs765848205", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs765848205" } ], "reference": [ { "type": "PubMed", "id": "12001123", "url": "https://glygen.org/publication/PubMed/12001123" } ] }, { "title": "Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity.", "journal": "Nature genetics", "date": "2002", "authors": "Bulavin DV, Demidov ON, Saito S, Kauraniemi P, Phillips C, Amundson SA, Ambrosino C, Sauter G, Nebreda AR, Anderson CW, Kallioniemi A, Fornace AJ Jr, Appella E", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "12021785", "url": "https://glygen.org/publication/PubMed/12021785" } ] }, { "title": "A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2002", "authors": "Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R", "evidence": [ { "database": "Reactome", "id": "R-HSA-983231", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983231" } ], "reference": [ { "type": "PubMed", "id": "12032298", "url": "https://glygen.org/publication/PubMed/12032298" } ] }, { "title": "Cdk5 phosphorylates p53 and regulates its activity.", "journal": "Journal of neurochemistry", "date": "2002", "authors": "Zhang J, Krishnamurthy PK, Johnson GV", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804756", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804756" }, { "database": "iPTMnet", "id": "P04637-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637-1" } ], "reference": [ { "type": "PubMed", "id": "12064478", "url": "https://glygen.org/publication/PubMed/12064478" } ] }, { "title": "Low dose of wortmannin reduces radiosensitivity of human glioblastoma cells through the p53 pathway.", "journal": "Oncology reports", "date": "2002", "authors": "Okaichi K, Suzuki K, Morita N, Ikeda M, Takahashi H, Matsuda N, Watanabe M, Okumura Y", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "12066222", "url": "https://glygen.org/publication/PubMed/12066222" } ] }, { "title": "UVB-mediated activation of p38 mitogen-activated protein kinase enhances resistance of normal human keratinocytes to apoptosis by stabilizing cytoplasmic p53.", "journal": "The Biochemical journal", "date": "2002", "authors": "Chouinard N, Valerie K, Rouabhia M, Huot J", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "12071847", "url": "https://glygen.org/publication/PubMed/12071847" } ] }, { "title": "Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Eloranta JJ, Hurst HC", "evidence": [ { "database": "Reactome", "id": "R-HSA-3232118", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3232118" } ], "reference": [ { "type": "PubMed", "id": "12072434", "url": "https://glygen.org/publication/PubMed/12072434" } ] }, { "title": "The processing of Holliday junctions by BLM and WRN helicases is regulated by p53.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Yang Q, Zhang R, Wang XW, Spillare EA, Linke SP, Subramanian D, Griffith JD, Li JL, Hickson ID, Shen JC, Loeb LA, Mazur SJ, Appella E, Brosh RM Jr, Karmakar P, Bohr VA, Harris CC", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "12080066", "url": "https://glygen.org/publication/PubMed/12080066" } ] }, { "title": "Frequent phosphorylation at serine 392 in overexpressed p53 protein due to missense mutation in carcinoma of the urinary tract.", "journal": "The Journal of pathology", "date": "2002", "authors": "Furihata M, Kurabayashl A, Matsumoto M, Sonobe H, Ohtsuki Y, Terao N, Kuwahara M, Shuin T", "evidence": [ { "database": "iPTMnet", 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J. Cancer", "date": "2002", "authors": "Lu X., Taylor G.R., Barnes D.M., Charlton R.S., Camplejohn R.S., Chu C.E., Chumas P., Duddy P.M., Rutherford J.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "12085209", "url": "https://glygen.org/publication/PubMed/12085209" } ] }, { "title": "Apoptotic threshold is lowered by p53 transactivation of caspase-6.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2002", "authors": "MacLachlan TK, El-Deiry WS", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803207" } ], "reference": [ { "type": "PubMed", "id": "12089322", "url": "https://glygen.org/publication/PubMed/12089322" } ] }, { "title": "p38 kinase regulates nitric oxide-induced apoptosis of articular chondrocytes by accumulating p53 via NFkappa B-dependent 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"https://glygen.org/publication/PubMed/12145207" } ] }, { "title": "ATM is activated in response to N-methyl-N'-nitro-N-nitrosoguanidine-induced DNA alkylation.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Adamson AW, Kim WJ, Shangary S, Baskaran R, Brown KD", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "12151394", "url": "https://glygen.org/publication/PubMed/12151394" } ] }, { "title": "Inactivation of human peroxiredoxin I during catalysis as the result of the oxidation of the catalytic site cysteine to cysteine-sulfinic acid.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Yang KS, Kang SW, Woo HA, Hwang SC, Chae HZ, Kim K, Rhee SG", "evidence": [ { "database": "Reactome", "id": "R-HSA-5628897", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5628897" } ], "reference": [ { "type": 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B, Bhattacharjee A, Xu B, Ford D, Maizel AL, Cathcart MK", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "12223527", "url": "https://glygen.org/publication/PubMed/12223527" } ] }, { "title": "Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2002", "authors": "Seki Y, Hayashi K, Matsumoto A, Seki N, Tsukada J, Ransom J, Naka T, Kishimoto T, Yoshimura A, Kubo M", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "12242343", "url": "https://glygen.org/publication/PubMed/12242343" } ] }, { "title": "Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways.", "journal": "Oncogene", "date": "2002", "authors": "Bahassi el M, Conn CW, Myer DL, Hennigan RF, McGowan CH, Sanchez Y, Stambrook PJ", "evidence": [ { "database": "iPTMnet", "id": "P04637-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637-1" } ], "reference": [ { "type": "PubMed", "id": "12242661", "url": "https://glygen.org/publication/PubMed/12242661" } ] }, { "title": "Transcription factor Sp3 is silenced through SUMO modification by PIAS1.", "journal": "The EMBO journal", "date": "2002", "authors": "Sapetschnig A, Rischitor G, Braun H, Doll A, Schergaut M, Melchior F, Suske G", "evidence": [ { "database": "Reactome", "id": "R-HSA-3232118", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3232118" } ], "reference": [ { "type": "PubMed", "id": "12356736", "url": "https://glygen.org/publication/PubMed/12356736" } ] }, { "title": "53BP1, a mediator of the DNA damage checkpoint.", "journal": 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"https://glygen.org/publication/PubMed/12393879" } ] }, { "title": "The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response.", "journal": "Nature", "date": "2002", "authors": "Zheng H, You H, Zhou XZ, Murray SA, Uchida T, Wulf G, Gu L, Tang X, Lu KP, Xiao ZX", "evidence": [ { "database": "iPTMnet", "id": "P04637-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637-1" } ], "reference": [ { "type": "PubMed", "id": "12397361", "url": "https://glygen.org/publication/PubMed/12397361" } ] }, { "title": "The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults.", "journal": "Nature", "date": "2002", "authors": "Zacchi P, Gostissa M, Uchida T, Salvagno C, Avolio F, Volinia S, Ronai Z, Blandino G, Schneider C, Del Sal G", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "12397362", "url": "https://glygen.org/publication/PubMed/12397362" } ] }, { "title": "BID regulation by p53 contributes to chemosensitivity.", "journal": "Nature cell biology", "date": "2002", "authors": "Sax JK, Fei P, Murphy ME, Bernhard E, Korsmeyer SJ, El-Deiry WS", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803204", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803204" } ], "reference": [ { "type": "PubMed", "id": "12402042", "url": "https://glygen.org/publication/PubMed/12402042" } ] }, { "title": "p53 and p21 form an inducible barrier that protects cells against cyclin E-cdk2 deregulation.", "journal": "Current biology : CB", "date": "2002", "authors": "Minella AC, Swanger J, Bryant E, Welcker M, Hwang H, Clurman BE", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "12419181", "url": "https://glygen.org/publication/PubMed/12419181" } ] }, { "title": 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"The Journal of biological chemistry", "date": "2003", "authors": "Lio YC, Mazin AV, Kowalczykowski SC, Chen DJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-983231", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983231" } ], "reference": [ { "type": "PubMed", "id": "12427746", "url": "https://glygen.org/publication/PubMed/12427746" } ] }, { "title": "Phosphorylation and hsp90 binding mediate heat shock stabilization of p53.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Wang C, Chen J", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "12427754", "url": "https://glygen.org/publication/PubMed/12427754" } ] }, { "title": "p53 Antiproliferative function is enhanced by aspartate substitution at threonine 18 and serine 20.", "journal": "Cancer biology & therapy", "date": "2002", "authors": "Jabbur JR, Zhang W", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "12432277", "url": "https://glygen.org/publication/PubMed/12432277" } ] }, { "title": "Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein.", "journal": "Genes & development", "date": "2002", "authors": "Kuzmichev A, Nishioka K, Erdjument-Bromage H, Tempst P, Reinberg D", "evidence": [ { "database": "Reactome", "id": "R-HSA-2559580", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2559580" } ], "reference": [ { "type": "PubMed", "id": "12435631", "url": "https://glygen.org/publication/PubMed/12435631" } ] }, { "title": "14-3-3 interacts with the tumor suppressor tuberin at Akt phosphorylation site(s).", "journal": "Cancer research", "date": "2002", "authors": "Liu MY, Cai S, Espejo A, Bedford MT, Walker CL", "evidence": [ { "database": 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response.", "journal": "Cell death and differentiation", "date": "2002", "authors": "Gatti L, Supino R, Perego P, Pavesi R, Caserini C, Carenini N, Righetti SC, Zuco V, Zunino F", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "12478472", "url": "https://glygen.org/publication/PubMed/12478472" } ] }, { "title": "Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chains.", "journal": "The EMBO journal", "date": "2002", "authors": "Mallery DL, Vandenberg CJ, Hiom K", "evidence": [ { "database": "Reactome", "id": "R-HSA-5693565", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5693565" } ], "reference": [ { "type": "PubMed", "id": "12485996", "url": "https://glygen.org/publication/PubMed/12485996" } ] }, { "title": "Direct interaction with and activation of p53 by SMAR1 retards cell-cycle progression at G2/M phase and delays tumor growth in mice.", "journal": "International journal of cancer", "date": "2003", "authors": "Kaul R, Mukherjee S, Ahmed F, Bhat MK, Chhipa R, Galande S, Chattopadhyay S", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804759", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804759" } ], "reference": [ { "type": "PubMed", "id": "12494467", "url": "https://glygen.org/publication/PubMed/12494467" } ] }, { "title": "DNA-dependent acetylation of p53 by the transcription coactivator p300.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Dornan D, Shimizu H, Perkins ND, Hupp TR", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "12499368", "url": "https://glygen.org/publication/PubMed/12499368" } ] }, { "title": "Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex.", "journal": "Genes & development", "date": "2002", "authors": "Guenther MG, Yu J, Kao GD, Yen TJ, Lazar MA", "evidence": [ { "database": "Reactome", "id": "R-HSA-390471", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-390471" } ], "reference": [ { "type": "PubMed", "id": "12502735", "url": "https://glygen.org/publication/PubMed/12502735" } ] }, { "title": "Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde.", "journal": "Cell", "date": "2002", "authors": "Cohen R.E., Gu W., Li M., Li P., Shi Y., Yao T., Li W., Hu M., Wu J.-W.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "12507430", "url": "https://glygen.org/publication/PubMed/12507430" } ] }, { "title": "Nitric oxide-induced cellular stress and p53 activation in chronic inflammation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2003", "authors": "Hofseth LJ, Saito S, Hussain SP, Espey MG, Miranda KM, Araki Y, Jhappan C, Higashimoto Y, He P, Linke SP, Quezado MM, Zurer I, Rotter V, Wink DA, Appella E, Harris CC", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "12518062", "url": "https://glygen.org/publication/PubMed/12518062" } ] }, { "title": "ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Hammond EM, Dorie MJ, Giaccia AJ", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "12519769", "url": "https://glygen.org/publication/PubMed/12519769" } ] }, { "title": "Identification of a functional link for the p53 tumor suppressor protein in dexamethasone-induced growth suppression.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Urban G, Golden T, Aragon IV, Cowsert L, Cooper SR, Dean NM, Honkanen RE", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "12519780", "url": "https://glygen.org/publication/PubMed/12519780" } ] }, { "title": "iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human.", "journal": "Nat. Genet.", "date": "2003", "authors": "Lu X., Samuels Y., Bergamaschi D., Campargue I., Crook T., Hsieh J.-K., O'Connor D.J., Trigiante G., Zhong S., Kuwabara P.E., O'Neil N.J., Tomlinson M.L.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "Reactome", "id": "R-HSA-6804759", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804759" } ], "reference": [ { "type": "PubMed", "id": "12524540", "url": "https://glygen.org/publication/PubMed/12524540" } ] }, { "title": "The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun N-terminal kinase.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Pluquet O, North S, Bhoumik A, Dimas K, Ronai Z, Hainaut P", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "12531896", 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Natl. Acad. Sci. U.S.A.", "date": "2003", "authors": "Elliott G., Lu Y., Ma W., Mak T.W., Wakeham A., Kondo S., Benchimol S., Lowe S.W., Debbas M., Itie A., Lin A.W., Saris C., Sarosi I., Thukral S.K., Tuan J.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "Reactome", "id": "R-HSA-6804756", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804756" } ], "reference": [ { "type": "PubMed", "id": "12702766", "url": "https://glygen.org/publication/PubMed/12702766" } ] }, { "title": "Peroxiredoxin evolution and the regulation of hydrogen peroxide signaling.", "journal": "Science (New York, N.Y.)", "date": "2003", "authors": "Wood ZA, Poole LB, Karplus PA", "evidence": [ { "database": "Reactome", "id": "R-HSA-5628897", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5628897" } ], "reference": [ { "type": "PubMed", "id": "12714747", "url": "https://glygen.org/publication/PubMed/12714747" } ] }, { "title": "Nitric oxide promotes p53 nuclear retention and sensitizes neuroblastoma cells to apoptosis by ionizing radiation.", "journal": "Cell death and differentiation", "date": "2003", "authors": "Wang X, Zalcenstein A, Oren M", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "12719724", "url": "https://glygen.org/publication/PubMed/12719724" } ] }, { "title": "Identification and characterization of a novel p300-mediated p53 acetylation site, lysine 305.", "journal": "J. 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Chem.", "date": "2003", "authors": "Lee S.C., Wang Y.H., Tsay Y.G., Tan B.C., Lo W.Y.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "12724314", "url": "https://glygen.org/publication/PubMed/12724314" } ] }, { "title": "p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity.", "journal": "Cancer Res.", "date": "2003", "authors": "Appella E., Yokota J., Miura K., Nagashima M., Higashimoto Y., Okamura S., Harris C.C., Shiseki M., Onogi H., Kitahama-Shiseki M., Pedeux R.M.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "12750254", "url": "https://glygen.org/publication/PubMed/12750254" } ] }, { "title": "The cell cycle-regulated protein human GTSE-1 controls DNA damage-induced apoptosis by affecting p53 function.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Monte M, Benetti R, Buscemi G, Sandy P, Del Sal G, Schneider C", "evidence": [ { "database": "Reactome", "id": "R-HSA-69481", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-69481" } ], "reference": [ { "type": "PubMed", "id": "12750368", "url": "https://glygen.org/publication/PubMed/12750368" } ] }, { "title": "Regulatory interactions between the checkpoint kinase Chk1 and the proteins of the DNA-dependent protein kinase complex.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Goudelock DM, Jiang K, Pereira E, Russell B, Sanchez Y", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "12756247", "url": "https://glygen.org/publication/PubMed/12756247" } ] }, { "title": "Mutation of p53 in recurrent hepatocellular carcinoma and its association with the expression of ZBP-89.", "journal": "The American 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Biol. Chem.", "date": "2003", "authors": "Pandolfi P.P., Alsheich O., Grossman T., Haupt Y., Louria-Hayon I., Sionov R.V.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "12810724", "url": "https://glygen.org/publication/PubMed/12810724" } ] }, { "title": "Caffeine induces G2/M arrest and apoptosis via a novel p53-dependent pathway in NB4 promyelocytic leukemia cells.", "journal": "Journal of cellular physiology", "date": "2003", "authors": "Ito K, Nakazato T, Miyakawa Y, Yamato K, Ikeda Y, Kizaki M", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "12811820", "url": "https://glygen.org/publication/PubMed/12811820" } ] }, { "title": "STATs dimerize in the absence of phosphorylation.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Braunstein J, Brutsaert S, Olson R, Schindler C", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "12832402", "url": "https://glygen.org/publication/PubMed/12832402" } ] }, { "title": "Loss of Bard1, the heterodimeric partner of the Brca1 tumor suppressor, results in early embryonic lethality and chromosomal instability.", "journal": "Molecular and cellular biology", "date": "2003", "authors": "McCarthy EE, Celebi JT, Baer R, Ludwig T", "evidence": [ { "database": "Reactome", "id": "R-HSA-5693565", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5693565" } ], "reference": [ { "type": "PubMed", "id": "12832489", "url": "https://glygen.org/publication/PubMed/12832489" } ] }, { "title": "TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity.", "journal": "J. Biol. Chem.", "date": "2003", "authors": "Soddu S., Isnardon D., Malissen B., Dagorn J.-C., Dusetti N.J., Iovanna J.L., Carrier A., Cecchinelli B., Samir A.A., Tomasini R.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "Reactome", "id": "R-HSA-6804756", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804756" } ], "reference": [ { "type": "PubMed", "id": "12851404", "url": "https://glygen.org/publication/PubMed/12851404" } ] }, { "title": "NB1011 induces Ser15 phosphorylation of p53 and activates the G2/M checkpoint.", "journal": "Anti-cancer drugs", "date": "2003", "authors": "Dellinger RW, Karjian PL, Neuteboom ST", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "12853888", "url": "https://glygen.org/publication/PubMed/12853888" } ] }, { "title": "Ataxia telangiectasia-mutated protein can regulate p53 and neuronal death independent of Chk2 in response to DNA damage.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Keramaris E, Hirao A, Slack RS, Mak TW, Park DS", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "12857758", "url": "https://glygen.org/publication/PubMed/12857758" } ] }, { "title": "The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor.", "journal": "Cell", "date": "2003", "authors": "Gozani O, Karuman P, Jones DR, Ivanov D, Cha J, Lugovskoy AA, Baird CL, Zhu H, Field SJ, Lessnick SL, Villasenor J, Mehrotra B, Chen J, Rao VR, Brugge JS, Ferguson CG, Payrastre B, Myszka DG, Cantley LC, Wagner G, Divecha N, Prestwich GD, Yuan J", "evidence": [ { "database": "Reactome", "id": "R-HSA-6811555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811555" 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Mosialos G", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "12917689", "url": "https://glygen.org/publication/PubMed/12917689" } ] }, { "title": "The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination.", "journal": "Nature", "date": "2003", "authors": "Kovalenko A, Chable-Bessia C, Cantarella G, Israel A, Wallach D, Courtois G", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "12917691", "url": "https://glygen.org/publication/PubMed/12917691" } ] }, { "title": "Apoptotic cascade initiated by angiotensin II in neonatal cardiomyocytes: role of DNA damage.", "journal": "American journal of physiology. Heart and circulatory physiology", "date": "2003", "authors": "Grishko V, Pastukh V, Solodushko V, Gillespie M, Azuma J, Schaffer S", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "12919932", "url": "https://glygen.org/publication/PubMed/12919932" } ] }, { "title": "Nitric oxide prevents UV-induced phosphorylation of the p53 tumor-suppressor protein at serine 46: a possible role in inhibition of apoptosis.", "journal": "Biochemical and biophysical research communications", "date": "2003", "authors": "Fukunaga-Takenaka R, Fukunaga K, Tatemichi M, Ohshima H", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "12927814", "url": "https://glygen.org/publication/PubMed/12927814" } ] }, { "title": "The spectrum of mutations in TP53 in laryngeal cancer patients from a high-incidence population shows similarities to many of the known mutational hotspots.", "journal": "Cancer genetics and cytogenetics", "date": "2003", "authors": "Barnard D, Lehmann K, Hoal EG, van Helden PD, Victor TC", "evidence": [ { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ { "type": "PubMed", "id": "12935924", "url": "https://glygen.org/publication/PubMed/12935924" } ] }, { "title": "Therapy increases poly-ADP-ribose and p53-Ser392-P levels in recurrent squamous cell lung cancer.", "journal": "Neoplasma", "date": "2003", "authors": "Holownia A, Mroz RM, Kozlowski M, Chyczewska E, Laudanski J, Chyczewski L, Braszko JJ", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "12937839", "url": "https://glygen.org/publication/PubMed/12937839" } ] }, { "title": "Potential role of MLH1 in the induction of p53 and apoptosis by blocking transcription on damaged DNA templates.", "journal": "Molecular cancer research : MCR", "date": "2003", "authors": "Yanamadala S, Ljungman M", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "12939400", "url": "https://glygen.org/publication/PubMed/12939400" } ] }, { "title": "Nucleocytoplasmic shuttling of p53 is essential for MDM2-mediated cytoplasmic degradation but not ubiquitination.", "journal": "Mol. Cell. Biol.", "date": "2003", "authors": "Li H., Zhang Y., O'Keefe K.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "12944468", "url": "https://glygen.org/publication/PubMed/12944468" } ] }, { "title": "Activation of p53 protein in normal and in tumor cells by a novel anticancer agent CHS 828.", "journal": "Drugs under experimental and clinical research", "date": "2003", "authors": "Wojciechowski J, Lovborg H, Wesierska-Gadek J", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "12951835", "url": "https://glygen.org/publication/PubMed/12951835" } ] }, { "title": "Mutant p53 is constitutively phosphorylated at Serine 15 in UV-induced mouse skin tumors: involvement of ERK1/2 MAP kinase.", "journal": "Oncogene", "date": "2003", "authors": "Melnikova VO, Santamaria AB, Bolshakov SV, Ananthaswamy HN", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "12955074", "url": "https://glygen.org/publication/PubMed/12955074" } ] }, { "title": "Hyperoxia activates the ATR-Chk1 pathway and phosphorylates p53 at multiple sites.", "journal": "American journal of physiology. Lung cellular and molecular physiology", "date": "2004", "authors": "Das KC, Dashnamoorthy R", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "12959929", "url": "https://glygen.org/publication/PubMed/12959929" } ] }, { "title": "A novel mutation in the p53 gene in a Burkitt's lymphoma cell line.", "journal": "Hum. Mol. Genet.", "date": "1992", "authors": "Bhatia K., Guiterrez M.I., Magrath I.T.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "1303181", "url": "https://glygen.org/publication/PubMed/1303181" } ] }, { "title": "p53 mutations cluster at codon 249 in hepatitis B virus-positive hepatocellular carcinomas from China.", "journal": "Cancer research", "date": "1992", "authors": "Scorsone KA, Zhou YZ, Butel JS, Slagle BL", "evidence": [ { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ { "type": "PubMed", "id": "1311638", "url": "https://glygen.org/publication/PubMed/1311638" } ] }, { "title": "Expression of the MAPK kinases MKK-4 and MKK-7 in rheumatoid arthritis and their role as key regulators of JNK.", "journal": "Arthritis and rheumatism", "date": "2003", "authors": "Sundarrajan M, Boyle DL, Chabaud-Riou M, Hammaker D, Firestein GS", "evidence": [ { "database": "Reactome", "id": "R-HSA-2559580", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2559580" } ], "reference": [ { "type": "PubMed", "id": "13130464", "url": "https://glygen.org/publication/PubMed/13130464" } ] }, { "title": "Rab geranylgeranyl transferase. A multisubunit enzyme that prenylates GTP-binding proteins terminating in Cys-X-Cys or Cys-Cys.", "journal": "The Journal of biological chemistry", "date": "1992", "authors": "Seabra MC, Goldstein JL, Sudhof TC, Brown MS", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803205", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803205" } ], "reference": [ { "type": "PubMed", "id": "1321151", "url": "https://glygen.org/publication/PubMed/1321151" } ] }, { "title": "Aberrations of the p53 tumor suppressor gene in human non-small cell carcinomas of the lung.", "journal": "Cancer research", "date": "1992", "authors": "Kishimoto Y, Murakami Y, Shiraishi M, Hayashi K, Sekiya T", "evidence": [ { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ { "type": "PubMed", "id": "1324794", "url": "https://glygen.org/publication/PubMed/1324794" } ] }, { "title": "Mutation of p53 gene in hepatocellular carcinoma in Taiwan.", "journal": "Cancer research", "date": "1992", "authors": "Sheu JC, Huang GT, Lee PH, Chung JC, Chou HC, Lai MY, Wang JT, Lee HS, Shih LN, Yang PM, et al.", "evidence": [ { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ { "type": "PubMed", "id": "1327523", "url": "https://glygen.org/publication/PubMed/1327523" } ] }, { "title": "Properties of p53 mutations detected in primary and secondary cervical cancers suggest mechanisms of metastasis and involvement of environmental carcinogens.", "journal": "EMBO J.", "date": "1992", "authors": "Vousden K.H., Crook T.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "1327751", "url": "https://glygen.org/publication/PubMed/1327751" } ] }, { "title": "On the origin of cancer cells.", "journal": "Science (New York, N.Y.)", "date": "1956", "authors": "WARBURG O", "evidence": [ { "database": "Reactome", "id": "R-HSA-5628897", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5628897" } ], "reference": [ { "type": "PubMed", "id": "13298683", "url": "https://glygen.org/publication/PubMed/13298683" } ] }, { "title": "Clonal p53 mutation in primary cervical cancer: association with human-papillomavirus-negative tumours.", "journal": "Lancet (London, England)", "date": "1992", "authors": "Crook T, Wrede D, Tidy JA, Mason WP, Evans DJ, Vousden KH", "evidence": [ { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ { "type": "PubMed", "id": "1349102", "url": "https://glygen.org/publication/PubMed/1349102" } ] }, { "title": "Enzymes of the human erythrocyte. IV. Phosphoglucose isomerase, purification and properties.", "journal": "The Journal of biological chemistry", "date": "1958", "authors": "TSUBOI KK, ESTRADA J, HUDSON PB", "evidence": [ { "database": "Reactome", "id": "R-HSA-5628897", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5628897" } ], "reference": [ { "type": "PubMed", "id": "13538944", "url": "https://glygen.org/publication/PubMed/13538944" } ] }, { "title": "Delayed expression of apoptosis in X-irradiated human leukemic MOLT-4 cells transfected with mutant p53.", "journal": "Journal of radiation research", "date": "2003", "authors": "Nakano H, Yonekawa H, Shinohara K", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "13678348", "url": "https://glygen.org/publication/PubMed/13678348" } ] }, { "title": "Molecular cloning of the interleukin-1 beta converting enzyme.", "journal": "Science (New York, N.Y.)", "date": "1992", "authors": "Cerretti DP, Kozlosky CJ, Mosley B, Nelson N, Van Ness K, Greenstreet TA, March CJ, Kronheim SR, Druck T, Cannizzaro LA, et al.", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803207" } ], "reference": [ { "type": "PubMed", "id": "1373520", "url": "https://glygen.org/publication/PubMed/1373520" } ] }, { "title": "Frequent p53 mutations in head and neck cancer.", "journal": "Cancer Res.", "date": "1992", "authors": "Casey G., Incognito L.S., Lopez M.E., Merrick M.A., Schechter G.L., Somers K.D.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "1394225", "url": "https://glygen.org/publication/PubMed/1394225" } ] }, { "title": "Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53.", "journal": "Molecular and cellular biology", "date": "1992", "authors": "Lees-Miller SP, Sakaguchi K, Ullrich SJ, Appella E, Anderson CW", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "1406679", "url": "https://glygen.org/publication/PubMed/1406679" } ] }, { "title": "p53 mutations in Raji cells: characterization and localization relative to other Burkitt's lymphomas.", "journal": "Oncogene", "date": "1992", "authors": "Appella E., May P., Debuire B., Duthu A., Ehrhart J.C., Fiscella M., May E., Romano J.W.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "1437144", "url": "https://glygen.org/publication/PubMed/1437144" } ] }, { "title": "Clinicopathologic significance of genetic alterations in hepatocellular carcinoma.", "journal": "Cancer genetics and cytogenetics", "date": "2003", "authors": "Pang A, Ng IO, Fan ST, Kwong YL", "evidence": [ { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ { "type": "PubMed", "id": "14499690", "url": "https://glygen.org/publication/PubMed/14499690" } ] }, { "title": "HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2003", "authors": "Linares LK, Hengstermann A, Ciechanover A, Muller S, Scheffner M", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804757", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804757" } ], "reference": [ { "type": "PubMed", "id": "14507994", "url": "https://glygen.org/publication/PubMed/14507994" } ] }, { "title": "Activation of p53 signalling in acetylsalicylic acid-induced apoptosis in OC2 human oral cancer cells.", "journal": "European journal of clinical investigation", "date": "2003", "authors": "Ho CC, Yang XW, Lee TL, Liao PH, Yang SH, Tsai CH, Chou MY", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "14511359", "url": "https://glygen.org/publication/PubMed/14511359" } ] }, { "title": "Status of p53 phosphorylation and function in sensitive and resistant human cancer models exposed to platinum-based DNA damaging agents.", "journal": "Journal of cancer research and clinical oncology", "date": "2003", "authors": "Mujoo K, Watanabe M, Nakamura J, Khokhar AR, Siddik ZH", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "14513366", "url": "https://glygen.org/publication/PubMed/14513366" } ] }, { "title": "p53 N-terminal Ser-15 approximately P and Ser-20 approximately P levels in squamous cell lung cancer after radio/chemotherapy.", "journal": "American journal of respiratory cell and molecular biology", "date": "2004", "authors": "Mroz RM, Holownia A, Chyczewska E, Chyczewski L, Braszko JJ", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "14527925", "url": "https://glygen.org/publication/PubMed/14527925" } ] }, { "title": "EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer.", "journal": "The EMBO journal", "date": "2003", "authors": "Bracken AP, Pasini D, Capra M, Prosperini E, Colli E, Helin K", "evidence": [ { "database": "Reactome", "id": "R-HSA-2559580", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2559580" } ], "reference": [ { "type": "PubMed", "id": "14532106", "url": "https://glygen.org/publication/PubMed/14532106" } ] }, { "title": "Requirement of the MRN complex for ATM activation by DNA damage.", "journal": "The EMBO journal", "date": "2003", "authors": "Uziel T, Lerenthal Y, Moyal L, Andegeko Y, Mittelman L, Shiloh Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-2559586", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2559586" } ], "reference": [ { "type": "PubMed", "id": "14532133", "url": "https://glygen.org/publication/PubMed/14532133" } ] }, { "title": "Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations.", "journal": "J. Biol. Chem.", "date": "2004", "authors": "Allen M.D., Fersht A.R., Joerger A.C.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "14534297", "url": "https://glygen.org/publication/PubMed/14534297" } ] }, { "title": "Characterization of the tumor suppressor protein p53 as a protein kinase C substrate and a S100b-binding protein.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1992", "authors": "Baudier J, Delphin C, Grunwald D, Khochbin S, Lawrence JJ", "evidence": [ { "database": "iPTMnet", "id": "P04637-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637-1" } ], "reference": [ { "type": "PubMed", "id": "1454855", "url": "https://glygen.org/publication/PubMed/1454855" } ] }, { "title": "Effects of oligonucleotide N3'-->P5' thio-phosphoramidate (GRN163) targeting telomerase RNA in human multiple myeloma cells.", "journal": "Cancer research", "date": "2003", "authors": "Akiyama M, Hideshima T, Shammas MA, Hayashi T, Hamasaki M, Tai YT, Richardson P, Gryaznov S, Munshi NC, Anderson KC", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "14559802", "url": "https://glygen.org/publication/PubMed/14559802" } ] }, { "title": "BARD1 participates with BRCA1 in homology-directed repair of chromosome breaks.", "journal": "Molecular and cellular biology", "date": "2003", "authors": "Westermark UK, Reyngold M, Olshen AB, Baer R, Jasin M, Moynahan ME", "evidence": [ { "database": "Reactome", "id": "R-HSA-5693565", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5693565" } ], "reference": [ { "type": "PubMed", "id": "14560035", "url": "https://glygen.org/publication/PubMed/14560035" } ] }, { "title": "p53 functions through stress- and promoter-specific recruitment of transcription initiation components before and after DNA damage.", "journal": "Molecular cell", "date": "2003", "authors": "Espinosa JM, Verdun RE, Emerson BM", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804116", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804116" } ], "reference": [ { "type": "PubMed", "id": "14580351", "url": "https://glygen.org/publication/PubMed/14580351" } ] }, { "title": "The p53 tumor-suppressor gene and ras oncogene mutations in oral squamous-cell carcinoma.", "journal": "Int. J. Cancer", "date": "1992", "authors": "Yamamoto H., Ishii N., Enomoto S., Ueda M., Matsumoto Y., Tsuchida N., Sakai E., Rikimaru K.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "1459726", "url": "https://glygen.org/publication/PubMed/1459726" } ] }, { "title": "The proteasome inhibitor bortezomib stabilizes a novel active form of p53 in human LNCaP-Pro5 prostate cancer cells.", "journal": "Cancer research", "date": "2003", "authors": "Williams SA, McConkey DJ", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "14612532", "url": "https://glygen.org/publication/PubMed/14612532" } ] }, { "title": "Perp is a mediator of p53-dependent apoptosis in diverse cell types.", "journal": "Current biology : CB", "date": "2003", "authors": "Ihrie RA, Reczek E, Horner JS, Khachatrian L, Sage J, Jacks T, Attardi LD", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803205", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803205" } ], "reference": [ { "type": "PubMed", "id": "14614825", "url": "https://glygen.org/publication/PubMed/14614825" } ] }, { "title": "Effects of a melanogenic bicyclic monoterpene diol on cell cycle, p53, TNF-alpha, and PGE2 are distinct from those of UVB.", "journal": "Photodermatology, photoimmunology & photomedicine", "date": "2003", "authors": "Kraus E, Galvin JW, Boumakis S, Boamah EK, Canning MT, Yarosh DB, Brown DA", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "14617104", "url": "https://glygen.org/publication/PubMed/14617104" } ] }, { "title": "Detecting lung cancer in plasma with the use of multiple genetic markers.", "journal": "International journal of cancer", "date": "2004", "authors": "Andriani F, Conte D, Mastrangelo T, Leon M, Ratcliffe C, Roz L, Pelosi G, Goldstraw P, Sozzi G, Pastorino U", "evidence": [ { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ { "type": "PubMed", "id": "14618621", "url": "https://glygen.org/publication/PubMed/14618621" } ] }, { "title": "Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) decoy receptor TRAIL-R3 is up-regulated by p53 in breast tumor cells through a mechanism involving an intronic p53-binding site.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Ruiz de Almodovar C, Ruiz-Ruiz C, Rodriguez A, Ortiz-Ferron G, Redondo JM, Lopez-Rivas A", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803211", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803211" } ], "reference": [ { "type": "PubMed", "id": "14623878", "url": "https://glygen.org/publication/PubMed/14623878" } ] }, 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A549 cells by three functional STAT6-binding motifs located upstream of the transcription initiation site.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2003", "authors": "Hebenstreit D, Luft P, Schmiedlechner A, Regl G, Frischauf AM, Aberger F, Duschl A, Horejs-Hoeck J", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "14634100", "url": "https://glygen.org/publication/PubMed/14634100" } ] }, { "title": "Involvement of tumor suppressor protein p53 and p38 MAPK in caffeic acid phenethyl ester-induced apoptosis of C6 glioma cells.", "journal": "Biochemical pharmacology", "date": "2003", "authors": "Lee YJ, Kuo HC, Chu CY, Wang CJ, Lin WC, Tseng TH", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "14637186", "url": 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Natl. Acad. Sci. U.S.A.", "date": "2003", "authors": "Armatis P., Bernardino A.L., Groot K., Kanashiro C.A., Schally A.V., Varga J.L.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "14660794", "url": "https://glygen.org/publication/PubMed/14660794" } ] }, { "title": "Two isoforms of otubain 1 regulate T cell anergy via GRAIL.", "journal": "Nature immunology", "date": "2004", "authors": "Soares L, Seroogy C, Skrenta H, Anandasabapathy N, Lovelace P, Chung CD, Engleman E, Fathman CG", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "14661020", "url": "https://glygen.org/publication/PubMed/14661020" } ] }, { "title": "Gamma irradiation results in phosphorylation of p53 at serine-392 in human T-lymphocyte leukaemia cell line MOLT-4.", "journal": "Folia biologica", "date": "2003", "authors": "Szkanderova S, Vavrova J, Rezacova M, Vokurkova D, Pavlova S, Smardova J, Stulik J", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "14680293", "url": "https://glygen.org/publication/PubMed/14680293" } ] }, { "title": "Up-regulation of Bcl-2 homology 3 (BH3)-only proteins by E2F1 mediates apoptosis.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Hershko T, Ginsberg D", "evidence": [ { "database": "Reactome", "id": "R-HSA-111448", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-111448" } ], "reference": [ { "type": "PubMed", "id": "14684737", "url": "https://glygen.org/publication/PubMed/14684737" } ] }, { "title": "Caspase 10 levels are increased following DNA damage in a p53-dependent manner.", "journal": "Cancer biology & therapy", "date": "2003", "authors": "Rikhof B, Corn PG, El-Deiry WS", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803207" } ], "reference": [ { "type": "PubMed", "id": "14688482", "url": "https://glygen.org/publication/PubMed/14688482" } ] }, { "title": "Chromosomal comparative genomic hybridization abnormalities in early- and late-onset human breast cancers: correlation with disease progression and TP53 mutations.", "journal": "Cancer genetics and cytogenetics", "date": "2004", "authors": "Jong YJ, Li LH, Tsou MH, Chen YJ, Cheng SH, Wang-Wuu S, Tsai SF, Chen CM, Huang AT, Hsu MT, Lin CH", "evidence": [ { "database": "dbSNP", "id": "rs587782329", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs587782329" } ], "reference": [ { "type": "PubMed", "id": "14697642", "url": "https://glygen.org/publication/PubMed/14697642" } ] }, { "title": "Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53.", "journal": "Nat. Genet.", "date": "2004", "authors": "Yuan Z.M., Fujii S., Arlinghaus R.B., Bondaruk J., Czerniak B.A., Katayama H., Kawai H., Sasai K., Sen S., Suzuki F.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "Reactome", "id": "R-HSA-6804756", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804756" }, { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "14702041", "url": "https://glygen.org/publication/PubMed/14702041" } ] }, { "title": "hGTSE-1 expression stimulates cytoplasmic localization of p53.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Monte M, Benetti R, Collavin L, Marchionni L, Del Sal G, Schneider C", "evidence": [ { "database": "Reactome", "id": "R-HSA-69481", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-69481" } ], "reference": [ { "type": "PubMed", 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translocation of serine 15-phosphorylated p53.", "journal": "DNA and cell biology", "date": "2004", "authors": "Schultz L, Khera S, Sleve D, Heath J, Chang NS", "evidence": [ { "database": "iPTMnet", "id": "P04637-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637-1" } ], "reference": [ { "type": "PubMed", "id": "14965474", "url": "https://glygen.org/publication/PubMed/14965474" } ] }, { "title": "The Barrett's antigen anterior gradient-2 silences the p53 transcriptional response to DNA damage.", "journal": "Molecular & cellular proteomics : MCP", "date": "2004", "authors": "Pohler E, Craig AL, Cotton J, Lawrie L, Dillon JF, Ross P, Kernohan N, Hupp TR", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "14967811", "url": "https://glygen.org/publication/PubMed/14967811" } ] }, { "title": "Modulation of p53 transcription regulatory activity and post-translational modification by hepatitis C virus core protein.", "journal": "Oncogene", "date": "2004", "authors": "Kao CF, Chen SY, Chen JY, Wu Lee YH", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "14968111", "url": "https://glygen.org/publication/PubMed/14968111" } ] }, { "title": "Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation.", "journal": "Oncogene", "date": "2004", "authors": "Bahassi el M, Hennigan RF, Myer DL, Stambrook PJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804115", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804115" } ], "reference": [ { "type": "PubMed", "id": "14968113", "url": "https://glygen.org/publication/PubMed/14968113" } ] }, { "title": "p53 regulates thymic Notch1 activation.", "journal": "European journal of immunology", "date": "2004", "authors": "Laws AM, Osborne BA", 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Cell", "date": "2004", "authors": "Liu X., Li H.-H., Li A.G., Sheppard H.M.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "Reactome", "id": "R-HSA-6804756", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804756" }, { "database": "iPTMnet", "id": "P04637-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637-1" } ], "reference": [ { "type": "PubMed", "id": "15053879", "url": "https://glygen.org/publication/PubMed/15053879" } ] }, { "title": "A dynamic role of HAUSP in the p53-Mdm2 pathway.", "journal": "Mol. 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J.", "date": "2004", "authors": "Hirano T., Hasan M.K., Kaul S.C., Taira K., Wadhwa R., Yaguchi T., Minoda Y.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "15109303", "url": "https://glygen.org/publication/PubMed/15109303" } ] }, { "title": "Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis.", "journal": "Oncogene", "date": "2004", "authors": "Xie TX, Wei D, Liu M, Gao AC, Ali-Osman F, Sawaya R, Huang S", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "15116091", "url": "https://glygen.org/publication/PubMed/15116091" } ] }, { "title": "Phosphorylation of p53 on Thr55 by ERK2 is necessary for doxorubicin-induced p53 activation and cell death.", "journal": "Oncogene", "date": "2004", "authors": "Yeh PY, Chuang SE, Yeh KH, Song YC, Chang LL, Cheng AL", "evidence": [ { "database": "iPTMnet", "id": "P04637-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637-1" } ], "reference": [ { "type": "PubMed", "id": "15116093", "url": "https://glygen.org/publication/PubMed/15116093" } ] }, { "title": "Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53.", "journal": "Cancer research", "date": "2004", "authors": "Li CQ, Robles AI, Hanigan CL, Hofseth LJ, Trudel LJ, Harris CC, Wogan GN", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803204", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803204" } ], "reference": [ { "type": "PubMed", "id": "15126337", "url": "https://glygen.org/publication/PubMed/15126337" } ] }, { "title": "Clustering of minimal deleted regions reveals distinct genetic pathways of human hepatocellular carcinoma.", "journal": "Cancer research", "date": "2004", "authors": "Jou YS, Lee CS, Chang YH, Hsiao CF, Chen CF, Chao CC, Wu LS, Yeh SH, Chen DS, Chen PJ", "evidence": [ { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ { "type": "PubMed", "id": "15126338", "url": "https://glygen.org/publication/PubMed/15126338" } ] }, { "title": "E2F-7: a distinctive E2F family member with an unusual organization of DNA-binding domains.", "journal": "Oncogene", "date": "2004", "authors": "Logan N, Delavaine L, Graham A, Reilly C, Wilson J, Brummelkamp TR, Hijmans EM, Bernards R, La Thangue NB", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804116", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804116" } ], "reference": [ { "type": "PubMed", "id": "15133492", "url": "https://glygen.org/publication/PubMed/15133492" } ] }, { "title": "The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle.", "journal": "J. Mol. Biol.", "date": "2004", "authors": "Valle G., Faulkner G., Zara I., Guccione E., Kojic S., Krmac H., Martinelli V., Medeot E.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "15136035", "url": "https://glygen.org/publication/PubMed/15136035" } ] }, { "title": "Spectrum of p53 mutations in biopsies from breast cancer patients selected for preoperative chemotherapy analysed by the functional yeast assay to predict therapeutic response.", "journal": "Oncology reports", "date": "2004", "authors": "Deissler H, Kafka A, Schuster E, Sauer G, Kreienberg R, Zeillinger R", "evidence": [ { "database": "dbSNP", "id": "rs1597349147", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1597349147" }, { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ { "type": "PubMed", "id": "15138567", "url": "https://glygen.org/publication/PubMed/15138567" } ] }, { "title": "Topoisomerase poisons differentially activate DNA damage checkpoints through ataxia-telangiectasia mutated-dependent and -independent mechanisms.", "journal": "Molecular cancer therapeutics", "date": "2004", "authors": "Siu WY, Lau A, Arooz T, Chow JP, Ho HT, Poon RY", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "15141020", "url": "https://glygen.org/publication/PubMed/15141020" } ] }, { "title": "HTLV-I Tax induces a novel interaction between p65/RelA and p53 that results in inhibition of p53 transcriptional activity.", "journal": "Blood", "date": "2004", "authors": "Jeong SJ, Radonovich M, Brady JN, Pise-Masison CA", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": 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], "reference": [ { "type": "PubMed", "id": "15159417", "url": "https://glygen.org/publication/PubMed/15159417" } ] }, { "title": "Rapid and sensitive p53 alteration analysis in biopsies from lung cancer patients using a functional assay and a universal oligonucleotide array: a prospective study.", "journal": "Clinical cancer research : an official journal of the American Association for Cancer Research", "date": "2004", "authors": "Fouquet C, Antoine M, Tisserand P, Favis R, Wislez M, Commo F, Rabbe N, Carette MF, Milleron B, Barany F, Cadranel J, Zalcman G, Soussi T", "evidence": [ { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ { "type": "PubMed", "id": "15161705", "url": "https://glygen.org/publication/PubMed/15161705" } ] }, { "title": "The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells.", "journal": "Molecular cell", "date": "2004", 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"http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "15199542", "url": "https://glygen.org/publication/PubMed/15199542" } ] }, { "title": "Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention.", "journal": "The EMBO journal", "date": "2004", "authors": "Lukas C, Melander F, Stucki M, Falck J, Bekker-Jensen S, Goldberg M, Lerenthal Y, Jackson SP, Bartek J, Lukas J", "evidence": [ { "database": "Reactome", "id": "R-HSA-5693565", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5693565" } ], "reference": [ { "type": "PubMed", "id": "15201865", "url": "https://glygen.org/publication/PubMed/15201865" } ] }, { "title": "Proton pump coupled to cytochrome c oxidase in mitochondria.", "journal": "Nature", "date": "1977", "authors": "Wikstrom MK", "evidence": [ { "database": "Reactome", "id": "R-HSA-5628897", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5628897" } ], "reference": [ { "type": "PubMed", "id": "15223", "url": "https://glygen.org/publication/PubMed/15223" } ] }, { "title": "Differentiation-induced radioresistance in muscle cells.", "journal": "Molecular and cellular biology", "date": "2004", "authors": "Latella L, Lukas J, Simone C, Puri PL, Bartek J", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "15226436", "url": "https://glygen.org/publication/PubMed/15226436" } ] }, { "title": "Complexity of translationally controlled transcription factor Sp3 isoform expression.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Sapetschnig A, Koch F, Rischitor G, Mennenga T, Suske G", "evidence": [ { "database": "Reactome", "id": "R-HSA-3232118", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3232118" } ], "reference": [ { "type": "PubMed", "id": "15247228", "url": "https://glygen.org/publication/PubMed/15247228" } ] }, { "title": "The novel Cdc42 guanine nucleotide exchange factor, zizimin1, dimerizes via the Cdc42-binding CZH2 domain.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Meller N, Irani-Tehrani M, Ratnikov BI, Paschal BM, Schwartz MA", "evidence": [ { "database": "Reactome", "id": "R-HSA-983231", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983231" } ], "reference": [ { "type": "PubMed", "id": "15247287", "url": "https://glygen.org/publication/PubMed/15247287" } ] }, { "title": "Selenite-induced p53 Ser-15 phosphorylation and caspase-mediated apoptosis in LNCaP human prostate cancer cells.", "journal": "Molecular cancer therapeutics", "date": "2004", "authors": "Jiang C, Hu H, Malewicz B, Wang Z, Lu J", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "15252149", "url": "https://glygen.org/publication/PubMed/15252149" } ] }, { "title": "Herpes simplex virus type 1 infection induces the stabilization of p53 in a USP7- and ATM-independent manner.", "journal": "Journal of virology", "date": "2004", "authors": "Boutell C, Everett RD", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "15254178", "url": "https://glygen.org/publication/PubMed/15254178" } ] }, { "title": "De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling.", "journal": "Nature", "date": "2004", "authors": "Wertz IE, O'Rourke KM, Zhou H, Eby M, Aravind L, Seshagiri S, Wu P, Wiesmann C, Baker R, Boone DL, Ma A, Koonin EV, Dixit VM", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689896", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689896" } ], "reference": [ { "type": "PubMed", "id": "15258597", "url": "https://glygen.org/publication/PubMed/15258597" } ] }, { "title": "STAT-1 is activated by IL-4 and IL-13 in multiple cell types.", "journal": "Molecular immunology", "date": "2004", "authors": "Wang IM, Lin H, Goldman SJ, Kobayashi M", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "15261459", "url": "https://glygen.org/publication/PubMed/15261459" } ] }, { "title": "ATM-dependent CHK2 activation induced by anticancer agent, irofulven.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Wang J, Wiltshire T, Wang Y, Mikell C, Burks J, Cunningham C, Van Laar ES, Waters SJ, Reed E, Wang W", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "15269203", "url": "https://glygen.org/publication/PubMed/15269203" } ] }, { "title": "AMID is a p53-inducible gene downregulated in tumors.", "journal": "Oncogene", "date": "2004", "authors": "Wu M, Xu LG, Su T, Tian Y, Zhai Z, Shu HB", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803204", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803204" } ], "reference": [ { "type": "PubMed", "id": "15273740", "url": "https://glygen.org/publication/PubMed/15273740" } ] }, { "title": "Selenium compounds regulate p53 by common and distinctive mechanisms.", "journal": "Anticancer research", "date": "2004", "authors": "Smith ML, Lancia JK, Mercer TI, Ip C", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "15274301", "url": "https://glygen.org/publication/PubMed/15274301" } ] }, { "title": "H2AX: the histone guardian of the genome.", "journal": "DNA repair", "date": "2004", "authors": "Fernandez-Capetillo O, Lee A, Nussenzweig M, Nussenzweig A", "evidence": [ { "database": "Reactome", "id": "R-HSA-5693565", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5693565" } ], "reference": [ { "type": "PubMed", "id": "15279782", "url": "https://glygen.org/publication/PubMed/15279782" } ] }, { "title": "Catalysis and function of the p38 alpha.MK2a signaling complex.", "journal": "Biochemistry", "date": "2004", "authors": "Lukas SM, Kroe RR, Wildeson J, Peet GW, Frego L, Davidson W, Ingraham RH, Pargellis CA, Labadia ME, Werneburg BG", "evidence": [ { "database": "Reactome", "id": "R-HSA-2559580", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2559580" } ], "reference": [ { "type": "PubMed", "id": "15287722", "url": "https://glygen.org/publication/PubMed/15287722" } ] }, { "title": "p53 upregulates death receptor 4 expression through an intronic p53 binding site.", "journal": "Cancer research", "date": "2004", "authors": "Liu X, Yue P, Khuri FR, Sun SY", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803211", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803211" } ], "reference": [ { "type": "PubMed", "id": "15289308", "url": "https://glygen.org/publication/PubMed/15289308" } ] }, { "title": "Loss of caspase-8 activation pathway is a possible mechanism for CDDP resistance in human laryngeal squamous cell carcinoma, HEp-2 cells.", "journal": "International journal of oncology", "date": "2004", "authors": "Toyozumi Y, Arima N, Izumaru S, Kato S, Morimatsu M, Nakashima T", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "15289875", "url": "https://glygen.org/publication/PubMed/15289875" } ] }, { "title": "Hypoxia-induced nucleophosmin protects cell death through inhibition of p53.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Li J, Zhang X, Sejas DP, Bagby GC, Pang Q", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "15310764", "url": "https://glygen.org/publication/PubMed/15310764" } ] }, { "title": "[Experimental study on p53 gene mutation in keloid fibroblasts].", "journal": "Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns", "date": "2004", "authors": "Liu W, Jiang YH, Li YL, Lin ZH, Jiang H, Tan Q, Zhang JL, Wang ZM", "evidence": [ { "database": "dbSNP", "id": "rs587782329", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs587782329" } ], "reference": [ { "type": "PubMed", "id": "15312469", "url": "https://glygen.org/publication/PubMed/15312469" } ] }, { "title": "DNA damage induced by temozolomide signals to both ATM and ATR: role of the mismatch repair system.", "journal": "Molecular pharmacology", "date": "2004", "authors": "Caporali S, Falcinelli S, Starace G, Russo MT, Bonmassar E, Jiricny J, D'Atri S", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "15322239", "url": "https://glygen.org/publication/PubMed/15322239" } ] }, { "title": "The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses.", "journal": "Nature immunology", "date": "2004", "authors": "Boone DL, Turer EE, Lee EG, Ahmad RC, Wheeler MT, Tsui C, Hurley P, Chien M, Chai S, Hitotsumatsu O, McNally E, Pickart C, Ma A", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689896", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689896" } ], "reference": [ { "type": "PubMed", "id": "15334086", "url": "https://glygen.org/publication/PubMed/15334086" } ] }, { "title": "The N-terminal interferon-binding domain (IBiD) homology domain of p300 binds to peptides with homology to the p53 transactivation domain.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Finlan L, Hupp TR", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "15337767", "url": "https://glygen.org/publication/PubMed/15337767" } ] }, { "title": "Regulation of human p53 activity and cell localization by alternative splicing.", "journal": "Mol. Cell. Biol.", "date": "2004", "authors": "Stewart D., Ghosh A., Matlashewski G.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "RefSeq", "id": "NP_001263627", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263627" }, { "database": "RefSeq", "id": "NP_001263628", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263628" }, { "database": "RefSeq", "id": "NP_000537", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000537" }, { "database": "RefSeq", "id": "NP_001263626", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263626" } ], "reference": [ { "type": "PubMed", "id": "15340061", "url": "https://glygen.org/publication/PubMed/15340061" } ] }, { "title": "Structured DNA promotes phosphorylation of p53 by DNA-dependent protein kinase at serine 9 and threonine 18.", "journal": "European journal of biochemistry", "date": "2004", "authors": "Soubeyrand S, Schild-Poulter C, Hache RJ", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "15355354", "url": "https://glygen.org/publication/PubMed/15355354" } ] }, { "title": "The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation.", "journal": "Cell", "date": "1992", "authors": "Momand J, Zambetti GP, Olson DC, George D, Levine AJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804757", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804757" } ], "reference": [ { "type": "PubMed", "id": "1535557", "url": "https://glygen.org/publication/PubMed/1535557" } ] }, { "title": "Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins.", "journal": "Cell", "date": "2004", "authors": "Lisby M, Barlow JH, Burgess RC, Rothstein R", "evidence": [ { "database": "Reactome", "id": "R-HSA-2559586", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2559586" } ], "reference": [ { "type": "PubMed", "id": "15369670", "url": "https://glygen.org/publication/PubMed/15369670" } ] }, { "title": "NDRG1 is necessary for p53-dependent apoptosis.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Stein S, Thomas EK, Herzog B, Westfall MD, Rocheleau JV, Jackson RS 2nd, Wang M, Liang P", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803205", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803205" } ], "reference": [ { "type": "PubMed", "id": "15377670", "url": "https://glygen.org/publication/PubMed/15377670" } ] }, { "title": "Potentiality of DNA-dependent protein kinase to phosphorylate Ser46 of human p53.", "journal": "Biochemical and biophysical research communications", "date": "2004", "authors": "Komiyama S, Taniguchi S, Matsumoto Y, Tsunoda E, Ohto T, Suzuki Y, Yin HL, Tomita M, Enomoto A, Morita A, Suzuki T, Ohtomo K, Hosoi Y, Suzuki N", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "15381073", "url": "https://glygen.org/publication/PubMed/15381073" } ] }, { "title": "A highly conserved proapoptotic gene, IKIP, located next to the APAF1 gene locus, is regulated by p53.", "journal": "Cell death and differentiation", "date": "2004", "authors": "Hofer-Warbinek R, Schmid JA, Mayer H, Winsauer G, Orel L, Mueller B, Wiesner Ch, Binder BR, de Martin R", "evidence": [ { "database": "Reactome", "id": "R-HSA-9758274", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9758274" } ], "reference": [ { "type": "PubMed", "id": "15389287", "url": "https://glygen.org/publication/PubMed/15389287" } ] }, { "title": "A new effector pathway links ATM kinase with the DNA damage response.", "journal": "Nat. Cell Biol.", "date": "2004", "authors": "Xu D., Smith L., La Thangue N.B., Jansson M., Demonacos C., Krstic-Demonacos M., O'Connor D.P.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "Reactome", "id": "R-HSA-6804760", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804760" } ], "reference": [ { "type": "PubMed", "id": "15448695", "url": "https://glygen.org/publication/PubMed/15448695" } ] }, { "title": "Human PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Jowsey PA, Doherty AJ, Rouse J", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "15456759", "url": "https://glygen.org/publication/PubMed/15456759" } ] }, { "title": "Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break.", "journal": "Current biology : CB", "date": "2004", "authors": "Shroff R, Arbel-Eden A, Pilch D, Ira G, Bonner WM, Petrini JH, Haber JE, Lichten M", "evidence": [ { "database": "Reactome", "id": "R-HSA-2559586", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2559586" } ], "reference": [ { "type": "PubMed", "id": "15458641", "url": "https://glygen.org/publication/PubMed/15458641" } ] }, { "title": "The vaccinia virus B1R kinase induces p53 downregulation by an Mdm2-dependent mechanism.", "journal": "Virology", "date": "2004", "authors": "Santos CR, Vega FM, Blanco S, Barcia R, Lazo PA", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "15464845", "url": "https://glygen.org/publication/PubMed/15464845" } ] }, { "title": "Treatment of chronic myeloid leukemia cells with imatinib (STI571) impairs p53 accumulation in response to DNA damage.", "journal": "Cell cycle (Georgetown, Tex.)", "date": "2004", "authors": "Goldberg Z, Levav Y, Krichevsky S, Fibach E, Haupt Y", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "15467443", "url": "https://glygen.org/publication/PubMed/15467443" } ] }, { "title": "Aurora-A abrogation of p53 DNA binding and transactivation activity by phosphorylation of serine 215.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Liu Q, Kaneko S, Yang L, Feldman RI, Nicosia SV, Chen J, Cheng JQ", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "15469940", "url": "https://glygen.org/publication/PubMed/15469940" } ] }, { "title": "Phosphorylation of p53 on key serines is dispensable for transcriptional activation and apoptosis.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Thompson T, Tovar C, Yang H, Carvajal D, Vu BT, Xu Q, Wahl GM, Heimbrook DC, Vassilev LT", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "15471885", "url": "https://glygen.org/publication/PubMed/15471885" } ] }, { "title": "Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.", "journal": "Science (New York, N.Y.)", "date": "2004", "authors": "Weng AP, Ferrando AA, Lee W, Morris JP 4th, Silverman LB, Sanchez-Irizarry C, Blacklow SC, Look AT, Aster JC", "evidence": [ { "database": "Reactome", "id": "R-HSA-1912408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1912408" } ], "reference": [ { "type": "PubMed", "id": "15472075", "url": "https://glygen.org/publication/PubMed/15472075" } ] }, { "title": "p53 protein activates the transcription of human proliferating cell nuclear antigen in response to 4-nitroquinoline N-oxide treatment.", "journal": "The international journal of biochemistry & cell biology", "date": "2005", "authors": "Li Y, Wang L, Li S, Guo T, Guo X, Yan P, Chen Y, Wang L, Lu C", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "15474986", "url": "https://glygen.org/publication/PubMed/15474986" } ] }, { "title": "Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Kurz EU, Douglas P, Lees-Miller SP", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "15489221", "url": "https://glygen.org/publication/PubMed/15489221" } ] }, { "title": "Inhibition of p53-mediated transcriptional responses by mithramycin A.", "journal": "Oncogene", "date": "2004", "authors": "Koutsodontis G, Kardassis D", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "15489892", "url": "https://glygen.org/publication/PubMed/15489892" } ] }, { "title": "BCR/ABL recruits p53 tumor suppressor protein to induce drug resistance.", "journal": "Cell cycle (Georgetown, Tex.)", "date": "2004", "authors": "Stoklosa T, Slupianek A, Datta M, Nieborowska-Skorska M, Nowicki MO, Koptyra M, Skorski T", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "15492510", "url": "https://glygen.org/publication/PubMed/15492510" } ] }, { "title": "Phosphorylation state of tumor-suppressor gene p53 product overexpressed in skin tumors.", "journal": "Oncology reports", "date": "2004", "authors": "Matsumoto M, Furihata M, Kurabayashi A, Ohtsuki Y", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "15492790", "url": "https://glygen.org/publication/PubMed/15492790" } ] }, { "title": "Sumoylation of internally initiated Sp3 isoforms regulates transcriptional repression via a Trichostatin A-insensitive mechanism.", "journal": "Cellular signalling", "date": "2005", "authors": "Spengler ML, Kennett SB, Moorefield KS, Simmons SO, Brattain MG, Horowitz JM", "evidence": [ { "database": "Reactome", "id": "R-HSA-3232118", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3232118" } ], "reference": [ { "type": "PubMed", "id": "15494207", "url": "https://glygen.org/publication/PubMed/15494207" } ] }, { "title": "Sumoylation of MITF and its related family members TFE3 and TFEB.", "journal": "The Journal of biological chemistry", "date": "2005", "authors": "Miller AJ, Levy C, Davis IJ, Razin E, Fisher DE", "evidence": [ { "database": "Reactome", "id": "R-HSA-3232118", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3232118" } ], "reference": [ { "type": "PubMed", "id": "15507434", "url": "https://glygen.org/publication/PubMed/15507434" } ] }, { "title": "Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A.", "journal": "The EMBO journal", "date": "2004", "authors": "Goodarzi AA, Jonnalagadda JC, Douglas P, Young D, Ye R, Moorhead GB, Lees-Miller SP, Khanna KK", "evidence": [ { "database": "Reactome", "id": "R-HSA-2559586", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2559586" } ], "reference": [ { "type": "PubMed", "id": "15510216", "url": "https://glygen.org/publication/PubMed/15510216" } ] }, { "title": "Regulation of p53 activity through lysine methylation.", "journal": "Nature", "date": "2004", "authors": "Gamblin S.J., Xiao B., Reinberg D., Tempst P., Justin N., Prives C., Chuikov S., Wilson J.R., Barlev N.A., Ivanov G.S., Kurash J.K., McKinney K.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "Reactome", "id": "R-HSA-6804760", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804760" } ], "reference": [ { "type": "PubMed", "id": "15525938", "url": "https://glygen.org/publication/PubMed/15525938" } ] }, { "title": "Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation.", "journal": "The EMBO journal", "date": "2004", "authors": "Rui Y, Xu Z, Lin S, Li Q, Rui H, Luo W, Zhou HM, Cheung PY, Wu Z, Ye Z, Li P, Han J, Lin SC", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "15526030", "url": "https://glygen.org/publication/PubMed/15526030" } ] }, { "title": "Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage.", "journal": "The Journal of biological chemistry", "date": "2005", "authors": "Helt CE, Cliby WA, Keng PC, Bambara RA, O'Reilly MA", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "15533933", "url": "https://glygen.org/publication/PubMed/15533933" } ] }, { "title": "Prognostic significance of serine 392 phosphorylation in overexpressed p53 protein in human esophageal squamous cell carcinoma.", "journal": "Oncology", "date": "2004", "authors": "Matsumoto M, Furihata M, Kurabayashi A, Sasaguri S, Araki K, Hayashi H, Ohtsuki Y", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "15539919", "url": "https://glygen.org/publication/PubMed/15539919" } ] }, { "title": "Inhibitory effect of epidermal growth factor on resveratrol-induced apoptosis in prostate cancer cells is mediated by protein kinase C-alpha.", "journal": "Molecular cancer therapeutics", "date": "2004", "authors": "Shih A, Zhang S, Cao HJ, Boswell S, Wu YH, Tang HY, Lennartz MR, Davis FB, Davis PJ, Lin HY", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "15542774", "url": "https://glygen.org/publication/PubMed/15542774" } ] }, { "title": "p53 Stabilization and accumulation induced by human vaccinia-related kinase 1.", "journal": "Molecular and cellular biology", "date": "2004", "authors": "Vega FM, Sevilla A, Lazo PA", "evidence": [ { "database": "iPTMnet", "id": 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Med.", "date": "1992", "authors": "Look A.T., Andersen T.I., Friend S.H., Garber J., Li F.P., Malkin D., Strong L.C., Jolly K.W., Barbier N., Boerresen A.-L., Gebhardt M.C.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "1565144", "url": "https://glygen.org/publication/PubMed/1565144" } ] }, { "title": "The p400 E1A-associated protein is a novel component of the p53 --> p21 senescence pathway.", "journal": "Genes & development", "date": "2005", "authors": "Chan HM, Narita M, Lowe SW, Livingston DM", "evidence": [ { "database": "Reactome", "id": "R-HSA-2559584", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2559584" } ], "reference": [ { "type": "PubMed", "id": "15655109", "url": "https://glygen.org/publication/PubMed/15655109" } ] }, { "title": "Epigallocatechin-3-gallate induces apoptosis in estrogen receptor-negative human breast carcinoma cells via modulation in protein expression of p53 and Bax and caspase-3 activation.", "journal": "Molecular cancer therapeutics", "date": "2005", "authors": "Roy AM, Baliga MS, Katiyar SK", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "15657356", "url": "https://glygen.org/publication/PubMed/15657356" } ] }, { "title": "Roscovitine-induced up-regulation of p53AIP1 protein precedes the onset of apoptosis in human MCF-7 breast cancer cells.", "journal": "Molecular cancer therapeutics", "date": "2005", "authors": "Wesierska-Gadek J, Gueorguieva M, Horky M", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "15657359", "url": "https://glygen.org/publication/PubMed/15657359" } ] }, { "title": "Pharmacological and small interference RNA-mediated inhibition of breast cancer-associated fatty acid synthase (oncogenic antigen-519) synergistically enhances Taxol (paclitaxel)-induced cytotoxicity.", "journal": "International journal of cancer", "date": "2005", "authors": "Menendez JA, Vellon L, Colomer R, Lupu R", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "15657900", "url": "https://glygen.org/publication/PubMed/15657900" } ] }, { "title": "p53 C-terminal phosphorylation by CHK1 and CHK2 participates in the regulation of DNA-damage-induced C-terminal acetylation.", "journal": "Molecular biology of the cell", "date": "2005", "authors": "Ou YH, Chung PH, Sun TP, Shieh SY", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "15659650", "url": "https://glygen.org/publication/PubMed/15659650" } ] }, { "title": "Regulation of p21(WAF1/CIP1) stability by WISp39, a Hsp90 binding TPR protein.", "journal": "Molecular cell", "date": "2005", "authors": "Jascur T, Brickner H, Salles-Passador I, Barbier V, El Khissiin A, Smith B, Fotedar R, Fotedar A", "evidence": [ { "database": "Reactome", "id": "R-HSA-8852276", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8852276" } ], "reference": [ { "type": "PubMed", "id": "15664193", "url": "https://glygen.org/publication/PubMed/15664193" } ] }, { "title": "Function of polo-like kinase 3 in NF-kappaB-mediated proapoptotic response.", "journal": "The Journal of biological chemistry", "date": "2005", "authors": "Li Z, Niu J, Uwagawa T, Peng B, Chiao PJ", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "15671037", "url": "https://glygen.org/publication/PubMed/15671037" } ] }, { "title": "Molecular determinants of NOTCH4 transcription in vascular endothelium.", "journal": "Molecular and cellular biology", "date": "2005", "authors": "Wu J, Iwata F, Grass JA, Osborne CS, Elnitski L, Fraser P, Ohneda O, Yamamoto M, Bresnick EH", "evidence": [ { "database": "Reactome", "id": "R-HSA-1912408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1912408" } ], "reference": [ { "type": "PubMed", "id": "15684396", "url": "https://glygen.org/publication/PubMed/15684396" } ] }, { "title": "A mechanism of ubiquitin-independent proteasomal degradation of the tumor suppressors p53 and p73.", "journal": "Genes Dev.", "date": "2005", "authors": "Shaul Y., Asher G., Tsvetkov P., Kahana C.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "15687255", "url": "https://glygen.org/publication/PubMed/15687255" } ] }, { "title": "Tumor suppressor SMAR1 activates and stabilizes p53 through its arginine-serine-rich motif.", "journal": "J. 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Chem.", "date": "2005", "authors": "Jameel S., Chattopadhyay S., Pavithra L., Singh K., Jalota-Badhwar A., Kaul-Ghanekar R.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "Reactome", "id": "R-HSA-6804759", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804759" }, { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "15701641", "url": "https://glygen.org/publication/PubMed/15701641" } ] }, { "title": "Mutation analysis of p53, K-ras, and BRAF genes in colorectal cancer progression.", "journal": "Journal of cellular physiology", "date": "2005", "authors": "Calistri D, Rengucci C, Seymour I, Lattuneddu A, Polifemo AM, Monti F, Saragoni L, Amadori D", "evidence": [ { "database": "dbSNP", "id": "rs765848205", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs765848205" } ], "reference": [ 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"date": "2005", "authors": "Grimberg A, Coleman CM, Burns TF, Himelstein BP, Koch CJ, Cohen P, El-Deiry WS", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803211", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803211" } ], "reference": [ { "type": "PubMed", "id": "15769996", "url": "https://glygen.org/publication/PubMed/15769996" } ] }, { "title": "Identification of the mismatch repair genes PMS2 and MLH1 as p53 target genes by using serial analysis of binding elements.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2005", "authors": "Chen J, Sadowski I", "evidence": [ { "database": "Reactome", "id": "R-HSA-6796648", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6796648" } ], "reference": [ { "type": "PubMed", "id": "15781865", "url": "https://glygen.org/publication/PubMed/15781865" } ] }, { "title": "BARD1 induces apoptosis by catalysing phosphorylation of p53 by DNA-damage response kinase.", "journal": "Oncogene", "date": "2005", "authors": "Feki A, Jefford CE, Berardi P, Wu JY, Cartier L, Krause KH, Irminger-Finger I", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "15782130", "url": "https://glygen.org/publication/PubMed/15782130" } ] }, { "title": "Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2005", "authors": "Pereg Y, Shkedy D, de Graaf P, Meulmeester E, Edelson-Averbukh M, Salek M, Biton S, Teunisse AF, Lehmann WD, Jochemsen AG, Shiloh Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804757", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804757" } ], "reference": [ { "type": "PubMed", "id": "15788536", "url": "https://glygen.org/publication/PubMed/15788536" } ] }, { 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JS, Medrano T, Ablordeppey EA, Kitzman JM, Shiverick KT", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "15837074", "url": "https://glygen.org/publication/PubMed/15837074" } ] }, { "title": "Modulation of binding of DNA to the C-terminal domain of p53 by acetylation.", "journal": "Structure (London, England : 1993)", "date": "2005", "authors": "Friedler A, Veprintsev DB, Freund SM, von Glos KI, Fersht AR", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "15837201", "url": "https://glygen.org/publication/PubMed/15837201" } ] }, { "title": "The association of p53 mutations and p53 codon 72, Her 2 codon 655 and MTHFR C677T polymorphisms with breast cancer in Northern Greece.", "journal": "Cancer letters", "date": "2005", "authors": "Kalemi TG, Lambropoulos AF, Gueorguiev M, Chrisafi S, Papazisis KT, Kotsis A", "evidence": [ { "database": "Entrez", "id": "7157", "url": "https://www.ncbi.nlm.nih.gov/gene/7157" } ], "reference": [ { "type": "PubMed", "id": "15837541", "url": "https://glygen.org/publication/PubMed/15837541" } ] }, { "title": "Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors.", "journal": "Cancer cell", "date": "2005", "authors": "Lackner MR, Kindt RM, Carroll PM, Brown K, Cancilla MR, Chen C, de Silva H, Franke Y, Guan B, Heuer T, Hung T, Keegan K, Lee JM, Manne V, O'Brien C, Parry D, Perez-Villar JJ, Reddy RK, Xiao H, Zhan H, Cockett M, Plowman G, Fitzgerald K, Costa M, Ross-Macdonald P", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803205", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803205" } ], "reference": [ { "type": "PubMed", "id": "15837622", "url": "https://glygen.org/publication/PubMed/15837622" } ] }, { "title": 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Biol. Chem.", "date": "2005", "authors": "Cance W.G., Finch R., Golubovskaya V.M.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "15855171", "url": "https://glygen.org/publication/PubMed/15855171" } ] }, { "title": "AMP-activated protein kinase induces a p53-dependent metabolic checkpoint.", "journal": "Mol. 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Involvement of posttranslational phosphorylation in the interaction between wt p53 protein and poly(ADP-ribose) polymerase-1.", "journal": "Acta biochimica Polonica", "date": "2005", "authors": "Schmid G, Wojciechowski J, Wesierska-Gadek J", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16082409", "url": "https://glygen.org/publication/PubMed/16082409" } ] }, { "title": "Global phosphoproteome of HT-29 human colon adenocarcinoma cells.", "journal": "Journal of proteome research", "date": "2005", "authors": "Kim JE, Tannenbaum SR, White FM", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16083285", "url": "https://glygen.org/publication/PubMed/16083285" } ] }, { "title": "Usnic acid: a non-genotoxic compound with anti-cancer properties.", "journal": "Anti-cancer drugs", "date": "2005", "authors": "Mayer M, O'Neill MA, Murray KE, Santos-Magalhaes NS, Carneiro-Leao AM, Thompson AM, Appleyard VC", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16096427", "url": "https://glygen.org/publication/PubMed/16096427" } ] }, { "title": "Germline p53 mutation presenting as synchronous tumors.", "journal": "Journal of pediatric hematology/oncology", "date": "2005", "authors": "Cavalier ME, Davis MM, Croop JM", "evidence": [ { "database": "Entrez", "id": "7157", "url": "https://www.ncbi.nlm.nih.gov/gene/7157" } ], "reference": [ { "type": "PubMed", "id": "16096528", "url": "https://glygen.org/publication/PubMed/16096528" } ] }, { "title": "Human cytomegalovirus IE1-72 activates ataxia telangiectasia mutated kinase and a p53/p21-mediated growth arrest response.", "journal": "Journal of virology", "date": "2005", "authors": "Castillo JP, Frame FM, Rogoff HA, Pickering MT, Yurochko AD, Kowalik TF", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16103197", "url": "https://glygen.org/publication/PubMed/16103197" } ] }, { "title": "Role of Stat3 in regulating p53 expression and function.", "journal": "Molecular and cellular biology", "date": "2005", "authors": "Niu G, Wright KL, Ma Y, Wright GM, Huang M, Irby R, Briggs J, Karras J, Cress WD, Pardoll D, Jove R, Chen J, Yu H", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "16107692", "url": "https://glygen.org/publication/PubMed/16107692" } ] }, { "title": "p53 isoforms can regulate p53 transcriptional activity.", "journal": "Genes Dev.", "date": "2005", "authors": "Liu G., Lane D.P., Bourdon J.C., Saville M.K., Xirodimas D.P., Diot A., Fernandes K., Murray-Zmijewski F.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "RefSeq", "id": "NP_001263628", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263628" }, { "database": "RefSeq", "id": "NP_001263626", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263626" }, { "database": "RefSeq", "id": "NP_001263627", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263627" }, { "database": "RefSeq", "id": "NP_000537", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000537" } ], "reference": [ { "type": "PubMed", "id": "16131611", "url": "https://glygen.org/publication/PubMed/16131611" } ] }, { "title": "Role of p73 in regulating human caspase-1 gene transcription induced by interferon-{gamma} and cisplatin.", "journal": "The Journal of biological chemistry", "date": "2005", "authors": "Jain N, Gupta S, Sudhakar Ch, Radha V, Swarup G", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803207" } ], "reference": [ { "type": "PubMed", "id": "16135520", "url": "https://glygen.org/publication/PubMed/16135520" } ] }, { "title": "RUNX3 suppresses gastric epithelial cell growth by inducing p21(WAF1/Cip1) expression in cooperation with transforming growth factor {beta}-activated SMAD.", "journal": "Molecular and cellular biology", "date": "2005", "authors": "Chi XZ, Yang JO, Lee KY, Ito K, Sakakura C, Li QL, Kim HR, Cha EJ, Lee YH, Kaneda A, Ushijima T, Kim WJ, Ito Y, Bae SC", "evidence": [ { "database": "Reactome", "id": "R-HSA-8941855", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8941855" } ], "reference": [ { "type": "PubMed", "id": "16135801", "url": "https://glygen.org/publication/PubMed/16135801" } ] }, { "title": "Telomerase-immortalized human fibroblasts retain UV-induced mutagenesis and p53-mediated DNA damage responses.", "journal": "DNA repair", "date": "2006", "authors": "Porter PC, Clark DR, McDaniel LD, McGregor WG, States JC", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16140041", "url": "https://glygen.org/publication/PubMed/16140041" } ] }, { "title": "Identification of novel p53 target genes in ionizing radiation response.", "journal": "Cancer research", "date": "2005", "authors": "Jen KY, Cheung VG", "evidence": [ { "database": "Reactome", "id": "R-HSA-5628897", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5628897" } ], "reference": [ { "type": "PubMed", "id": "16140933", "url": "https://glygen.org/publication/PubMed/16140933" } ] }, { "title": "A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2005", "authors": "Sun Y, Jiang X, Chen S, Fernandes N, Price BD", "evidence": [ { "database": "Reactome", "id": "R-HSA-2559586", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2559586" } ], "reference": [ { "type": "PubMed", "id": "16141325", "url": "https://glygen.org/publication/PubMed/16141325" } ] }, { "title": "Amplification of a gene encoding a p53-associated protein in human sarcomas.", "journal": "Nature", "date": "1992", "authors": "Oliner JD, Kinzler KW, Meltzer PS, George DL, Vogelstein B", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804757", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804757" } ], "reference": [ { "type": "PubMed", "id": "1614537", "url": "https://glygen.org/publication/PubMed/1614537" } ] }, { "title": "DNA damage regulates Chk2 association with chromatin.", "journal": "The Journal of biological chemistry", "date": "2005", "authors": "Li J, Stern DF", "evidence": [ { "database": "Reactome", "id": "R-HSA-5693565", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5693565" } ], "reference": [ { "type": "PubMed", "id": "16150728", "url": "https://glygen.org/publication/PubMed/16150728" } ] }, { "title": "Transcriptional silencing of Polo-like kinase 2 (SNK/PLK2) is a frequent event in B-cell malignancies.", "journal": "Blood", "date": "2006", "authors": "Syed N, Smith P, Sullivan A, Spender LC, Dyer M, Karran L, O'Nions J, Allday M, Hoffmann I, Crawford D, Griffin B, Farrell PJ, Crook T", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804115", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804115" } ], "reference": [ { "type": "PubMed", "id": "16160013", "url": "https://glygen.org/publication/PubMed/16160013" } ] }, { "title": "ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage.", "journal": "The EMBO journal", "date": "2005", "authors": "Chen L, Gilkes DM, Pan Y, Lane WS, Chen J", "evidence": [ { "database": "Reactome", "id": 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"http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16180010", "url": "https://glygen.org/publication/PubMed/16180010" } ] }, { "title": "Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2005", "authors": "Berube C, Boucher LM, Ma W, Wakeham A, Salmena L, Hakem R, Yeh WC, Mak TW, Benchimol S", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803207" } ], "reference": [ { "type": "PubMed", "id": "16183742", "url": "https://glygen.org/publication/PubMed/16183742" } ] }, { "title": "Essential function for the kinase TAK1 in innate and adaptive immune responses.", "journal": "Nature immunology", "date": "2005", "authors": "Sato S, Sanjo H, Takeda K, Ninomiya-Tsuji J, Yamamoto M, Kawai T, Matsumoto K, Takeuchi O, Akira S", "evidence": [ { "database": "Reactome", "id": "R-HSA-2559580", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2559580" } ], "reference": [ { "type": "PubMed", "id": "16186825", "url": "https://glygen.org/publication/PubMed/16186825" } ] }, { "title": "Requirement of STAT3 activation for maximal collagenase-1 (MMP-1) induction by epidermal growth factor and malignant characteristics in T24 bladder cancer cells.", "journal": "Oncogene", "date": "2006", "authors": "Itoh M, Murata T, Suzuki T, Shindoh M, Nakajima K, Imai K, Yoshida K", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "16205632", "url": "https://glygen.org/publication/PubMed/16205632" } ] }, { "title": "Distinct E2F-mediated transcriptional program regulates p14ARF gene expression.", "journal": "The EMBO journal", "date": "2005", "authors": "Komori H, Enomoto M, Nakamura M, Iwanaga R, Ohtani K", "evidence": [ { "database": "Reactome", "id": "R-HSA-2559585", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2559585" } ], "reference": [ { "type": "PubMed", "id": "16211008", "url": "https://glygen.org/publication/PubMed/16211008" } ] }, { "title": "HIPK2 inhibits both MDM2 gene and protein by, respectively, p53-dependent and independent regulations.", "journal": "FEBS letters", "date": "2005", "authors": "Di Stefano V, Mattiussi M, Sacchi A, D'Orazi G", "evidence": [ { "database": "iPTMnet", "id": "P04637-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637-1" } ], "reference": [ { "type": "PubMed", "id": "16212962", "url": "https://glygen.org/publication/PubMed/16212962" } ] }, { "title": "Human ubiquitin specific protease 31 is a deubiquitinating enzyme implicated in activation of nuclear factor-kappaB.", "journal": "Cellular signalling", "date": "2006", "authors": "Tzimas C, Michailidou G, Arsenakis M, Kieff E, Mosialos G, Hatzivassiliou EG", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "16214042", "url": "https://glygen.org/publication/PubMed/16214042" } ] }, { "title": "WOX1 is essential for tumor necrosis factor-, UV light-, staurosporine-, and p53-mediated cell death, and its tyrosine 33-phosphorylated form binds and stabilizes serine 46-phosphorylated p53.", "journal": "J. Biol. Chem.", "date": "2005", "authors": "Doherty J., Chang N.-S., Ensign A., Hong Q., Hsu L.-J., Schultz L.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16219768", "url": "https://glygen.org/publication/PubMed/16219768" } ] }, { "title": "WMC-79, a potent agent against colon cancers, induces apoptosis through a p53-dependent pathway.", "journal": "Molecular cancer therapeutics", "date": "2005", "authors": "Kosakowska-Cholody T, Cholody WM, Monks A, Woynarowska BA, Michejda CJ", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16227412", "url": "https://glygen.org/publication/PubMed/16227412" } ] }, { "title": "Endoplasmic reticulum stress accelerates p53 degradation by the cooperative actions of Hdm2 and glycogen synthase kinase 3beta.", "journal": "Molecular and cellular biology", "date": "2005", "authors": "Pluquet O, Qu LK, Baltzis D, Koromilas AE", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16227590", "url": "https://glygen.org/publication/PubMed/16227590" } ] }, { "title": "Gefitinib, a selective EGFR tyrosine kinase inhibitor, induces apoptosis through activation of Bax in human gallbladder adenocarcinoma cells.", "journal": "Journal of cellular biochemistry", "date": "2006", "authors": "Ariyama H, Qin B, Baba E, Tanaka R, Mitsugi K, Harada M, Nakano S", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16229013", "url": "https://glygen.org/publication/PubMed/16229013" } ] }, { "title": "Decoy receptor 2 (DcR2) is a p53 target gene and regulates chemosensitivity.", "journal": "Cancer research", "date": "2005", "authors": "Liu X, Yue P, Khuri FR, Sun SY", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803211", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803211" } ], "reference": [ { "type": "PubMed", "id": "16230375", "url": "https://glygen.org/publication/PubMed/16230375" } ] }, { "title": "Essential role of STAT3 in cytokine-driven NF-kappaB-mediated serum amyloid A gene expression.", "journal": "Genes to cells : devoted to molecular & cellular mechanisms", "date": "2005", "authors": "Hagihara K, Nishikawa T, Sugamata Y, Song J, Isobe T, Taga T, Yoshizaki K", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "16236134", "url": "https://glygen.org/publication/PubMed/16236134" } ] }, { "title": "Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells.", "journal": "Oncogene", "date": "2006", "authors": "Ichwan SJ, Yamada S, Sumrejkanchanakij P, Ibrahim-Auerkari E, Eto K, Ikeda MA", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16247456", "url": "https://glygen.org/publication/PubMed/16247456" } ] }, { "title": "BCL6 is regulated by p53 through a response element frequently disrupted in B-cell non-Hodgkin lymphoma.", "journal": "Blood", "date": "2006", "authors": "Margalit O, Amram H, Amariglio N, Simon AJ, Shaklai S, Granot G, Minsky N, Shimoni A, Harmelin A, Givol D, Shohat M, Oren M, Rechavi G", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803205", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803205" } ], "reference": [ { "type": "PubMed", "id": "16249378", "url": "https://glygen.org/publication/PubMed/16249378" } ] }, { "title": "Disruption of an intermonomer salt bridge in the p53 tetramerization domain results in an increased propensity to form amyloid fibrils.", "journal": "Protein science : a publication of the Protein Society", "date": "2005", "authors": "Galea C, Bowman P, Kriwacki RW", "evidence": [ { "database": "Entrez", "id": "7157", "url": "https://www.ncbi.nlm.nih.gov/gene/7157" } ], "reference": [ { "type": "PubMed", "id": "16260757", "url": "https://glygen.org/publication/PubMed/16260757" } ] }, { "title": "Ubiquitination of p21Cip1/WAF1 by SCFSkp2: substrate requirement and ubiquitination site selection.", "journal": "Biochemistry", "date": "2005", "authors": "Wang W, Nacusi L, Sheaff RJ, Liu X", "evidence": [ { "database": "Reactome", "id": "R-HSA-2559586", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2559586" } ], "reference": [ { "type": "PubMed", "id": "16262255", "url": "https://glygen.org/publication/PubMed/16262255" } ] }, { "title": "DNA replication stress-induced phosphorylation of cyclic AMP response element-binding protein mediated by ATM.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Dodson GE, Tibbetts RS", "evidence": [ { "database": "iPTMnet", "id": "P04637-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637-1" } ], "reference": [ { "type": "PubMed", "id": "16293623", "url": "https://glygen.org/publication/PubMed/16293623" } ] }, { "title": "Age dependent phosphorylation and deregulation of p53 in human vestibular schwannomas.", "journal": "Molecular carcinogenesis", "date": "2006", "authors": "Dayalan AH, Jothi M, Keshava R, Thomas R, Gope ML, Doddaballapur SK, Somanna S, Praharaj SS, Ashwathnarayanarao CB, Gope R", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16299809", "url": "https://glygen.org/publication/PubMed/16299809" } ] }, { "title": "Curcumin induces human HT-29 colon adenocarcinoma cell apoptosis by activating p53 and regulating apoptosis-related protein expression.", "journal": "Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas", "date": "2005", "authors": "Song G, Mao YB, Cai QF, Yao LM, Ouyang GL, Bao SD", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16302093", "url": "https://glygen.org/publication/PubMed/16302093" } ] }, { "title": "Inducible processing of interferon regulatory factor-2.", "journal": "Molecular and cellular biology", "date": "1992", "authors": "Palombella VJ, Maniatis T", "evidence": [ { "database": "Reactome", "id": "R-HSA-983231", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983231" } ], "reference": [ { "type": 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Natl. Acad. Sci. U.S.A.", "date": "1992", "authors": "Sun Y., Cao Y., Chen J.-Y., Colburn N.H., Chen I.-H., Hegamyer G., Heng Y.-J., Hildesheim A., Yao K.-T.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "1631151", "url": "https://glygen.org/publication/PubMed/1631151" } ] }, { "title": "The p53 oncoprotein is a substrate for tissue transglutaminase kinase activity.", "journal": "Biochemical and biophysical research communications", "date": "2006", "authors": "Mishra S, Murphy LJ", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16313886", "url": "https://glygen.org/publication/PubMed/16313886" } ] }, { "title": "Regulation of p53 by activated protein kinase C-delta during nitric oxide-induced dopaminergic cell death.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Lee SJ, Kim DC, Choi BH, Ha H, Kim KT", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16314418", "url": "https://glygen.org/publication/PubMed/16314418" } ] }, { "title": "A peroxisome proliferator-activated receptor-gamma agonist, troglitazone, facilitates caspase-8 and -9 activities by increasing the enzymatic activity of protein-tyrosine phosphatase-1B on human glioma cells.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Akasaki Y, Liu G, Matundan HH, Ng H, Yuan X, Zeng Z, Black KL, Yu JS", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16319070", "url": "https://glygen.org/publication/PubMed/16319070" } ] }, { "title": "ATM is activated by default in mitosis, localizes at centrosomes and monitors mitotic spindle integrity.", "journal": "Cell cycle (Georgetown, Tex.)", "date": "2006", "authors": "Oricchio E, Saladino C, Iacovelli S, Soddu S, Cundari E", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16319535", "url": "https://glygen.org/publication/PubMed/16319535" } ] }, { "title": "Hepatitis C virus core protein inhibits tumor suppressor protein promyelocytic leukemia function in human hepatoma cells.", "journal": "Cancer research", "date": "2005", "authors": "Herzer K, Weyer S, Krammer PH, Galle PR, Hofmann TG", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16322229", "url": "https://glygen.org/publication/PubMed/16322229" } ] }, { "title": "Clinical relevance of dominant-negative p73 isoforms for responsiveness to chemotherapy and survival in ovarian cancer: evidence for a crucial p53-p73 cross-talk in vivo.", "journal": "Clinical cancer research : an official journal of the American Association for Cancer Research", "date": "2005", "authors": "Concin N, Hofstetter G, Berger A, Gehmacher A, Reimer D, Watrowski R, Tong D, Schuster E, Hefler L, Heim K, Mueller-Holzner E, Marth C, Moll UM, Zeimet AG, Zeillinger R", "evidence": [ { "database": "dbSNP", "id": "rs587782329", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs587782329" } ], "reference": [ { "type": "PubMed", "id": "16322298", "url": "https://glygen.org/publication/PubMed/16322298" } ] }, { "title": "NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.", "journal": "Genes Dev.", "date": "2005", "authors": "van Dorsselaer A., Metzger E., Schule R., Miguet L., Kunowska N., Muller J.M., Yin N., Heyne K., Roemer K., Fritzsche C., Hublitz P., Mayer U.P., Poli C., Potiers N., Schupp I.W., van Grunsven L.A.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "Reactome", "id": "R-HSA-6804756", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804756" } ], "reference": [ { "type": "PubMed", "id": "16322561", "url": "https://glygen.org/publication/PubMed/16322561" } ] }, { "title": "The involvement of MAPK signaling pathways in determining the cellular response to p53 activation: cell cycle arrest or apoptosis.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Brown L, Benchimol S", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16330547", "url": "https://glygen.org/publication/PubMed/16330547" } ] }, { "title": "Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells.", "journal": "Molecular cell", "date": "2005", "authors": "Nicke B, Bastien J, Khanna SJ, Warne PH, Cowling V, Cook SJ, Peters G, Delpuech O, Schulze A, Berns K, Mullenders J, Beijersbergen RL, Bernards R, Ganesan TS, Downward J, Hancock DC", "evidence": [ { "database": "Reactome", "id": "R-HSA-2559580", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2559580" } ], "reference": [ { "type": "PubMed", "id": "16337592", "url": "https://glygen.org/publication/PubMed/16337592" } ] }, { "title": "Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon.", "journal": "FEBS Lett.", "date": "2006", "authors": "Baek K.-H., Choi J.-K., Gu Y.-M., Jin Y.-H., Lee K.-Y., Yeo C.-Y.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "16376338", "url": "https://glygen.org/publication/PubMed/16376338" } ] }, { "title": "MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks.", "journal": "Cell", "date": "2005", "authors": "Stucki M, Clapperton JA, Mohammad D, Yaffe MB, Smerdon SJ, Jackson SP", "evidence": [ { "database": "Reactome", "id": "R-HSA-5693565", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5693565" } ], "reference": [ { "type": "PubMed", "id": "16377563", "url": "https://glygen.org/publication/PubMed/16377563" } ] }, { "title": "Protein kinase C delta regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage.", "journal": "J. Biol. Chem.", "date": "2006", "authors": "Liu H., Miki Y., Yoshida K.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16377624", "url": "https://glygen.org/publication/PubMed/16377624" } ] }, { "title": "Hzf, a p53-responsive gene, regulates maintenance of the G2 phase checkpoint induced by DNA damage.", "journal": "Molecular and cellular biology", "date": "2006", "authors": "Sugimoto M, Gromley A, Sherr CJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804759", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804759" } ], "reference": [ { "type": "PubMed", "id": "16382142", "url": "https://glygen.org/publication/PubMed/16382142" } ] }, { "title": "Persistent activation of stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells.", "journal": "Clinical cancer research : an official journal of the American Association for Cancer Research", "date": "2006", "authors": "Gritsko T, Williams A, Turkson J, Kaneko S, Bowman T, Huang M, Nam S, Eweis I, Diaz N, Sullivan D, Yoder S, Enkemann S, Eschrich S, Lee JH, Beam CA, Cheng J, Minton S, Muro-Cacho CA, Jove R", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "16397018", "url": "https://glygen.org/publication/PubMed/16397018" } ] }, { "title": "XRCC1 is phosphorylated by DNA-dependent protein kinase in response to DNA damage.", "journal": "Nucleic acids research", "date": "2006", "authors": "Levy N, Martz A, Bresson A, Spenlehauer C, de Murcia G, Menissier-de Murcia J", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16397295", "url": "https://glygen.org/publication/PubMed/16397295" } ] }, { "title": "Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway.", "journal": "PLoS Biol.", "date": "2006", "authors": "Gu W., Li M., Shi Y., Jeffrey P.D., Gu L., Hu M.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "Reactome", "id": "R-HSA-6804757", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804757" } ], "reference": [ { "type": "PubMed", "id": "16402859", "url": "https://glygen.org/publication/PubMed/16402859" } ] }, { "title": "A global map of p53 transcription-factor binding sites in the human genome.", "journal": "Cell", "date": "2006", "authors": "Wei CL, Wu Q, Vega VB, Chiu KP, Ng P, Zhang T, Shahab A, Yong HC, Fu Y, Weng Z, Liu J, Zhao XD, Chew JL, Lee YL, Kuznetsov VA, Sung WK, Miller LD, Lim B, Liu ET, Yu Q, Ng HH, Ruan Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-5628897", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5628897" } ], "reference": [ { "type": "PubMed", "id": "16413492", "url": "https://glygen.org/publication/PubMed/16413492" } ] }, { "title": "Monochloramine inhibits ultraviolet B-induced p53 activation and DNA repair response in human fibroblasts.", "journal": "Biochimica et biophysica acta", "date": "2006", "authors": "Hiramatsu K, Ogino T, Ozaki M, Okada S", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16414131", "url": "https://glygen.org/publication/PubMed/16414131" } ] }, { "title": "Structural basis for the methylation site specificity of SET7/9.", "journal": "Nat. Struct. Mol. Biol.", "date": "2006", "authors": "Couture J.-F., Hauk G., Trievel R.C., Collazo E.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "Reactome", "id": "R-HSA-6804760", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804760" } ], "reference": [ { "type": "PubMed", "id": "16415881", "url": "https://glygen.org/publication/PubMed/16415881" } ] }, { "title": "Up-regulation of PTEN (phosphatase and tensin homolog deleted on chromosome ten) mediates p38 MAPK stress signal-induced inhibition of insulin signaling. A cross-talk between stress signaling and insulin signaling in resistin-treated human endothelial cells.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Shen YH, Zhang L, Gan Y, Wang X, Wang J, LeMaire SA, Coselli JS, Wang XL", "evidence": [ { "database": "Reactome", "id": "R-HSA-8943724", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8943724" } ], "reference": [ { "type": "PubMed", "id": "16418168", "url": "https://glygen.org/publication/PubMed/16418168" } ] }, { "title": "MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals.", "journal": "Molecular cell", "date": "2006", "authors": "Lou Z, Minter-Dykhouse K, Franco S, Gostissa M, Rivera MA, Celeste A, Manis JP, van Deursen J, Nussenzweig A, Paull TT, Alt FW, Chen J", "evidence": [ { "database": "Reactome", "id": "R-HSA-5693565", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5693565" } ], "reference": [ { "type": "PubMed", "id": "16427009", "url": "https://glygen.org/publication/PubMed/16427009" } ] }, { "title": "Infrared radiation induces the p53 signaling pathway: role in infrared prevention of ultraviolet B toxicity.", "journal": "Experimental dermatology", "date": "2006", "authors": "Frank S, Menezes S, Lebreton-De Coster C, Oster M, Dubertret L, Coulomb B", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16433685", "url": "https://glygen.org/publication/PubMed/16433685" } ] }, { "title": "DNA damage signaling and p53-dependent senescence after prolonged beta-interferon stimulation.", "journal": "Molecular biology of the cell", "date": "2006", "authors": "Moiseeva O, Mallette FA, Mukhopadhyay UK, Moores A, Ferbeyre G", "evidence": [ { "database": "Reactome", "id": "R-HSA-2559580", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2559580" }, { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16436515", "url": "https://glygen.org/publication/PubMed/16436515" } ] }, { "title": "TP53 and p16INK4A, but not H-KI-Ras, are involved in tumorigenesis and progression of pleomorphic adenomas.", "journal": "Journal of cellular physiology", "date": "2006", "authors": "Augello C, Gregorio V, Bazan V, Cammareri P, Agnese V, Cascio S, Corsale S, Calo V, Gullo A, Passantino R, Gargano G, Bruno L, Rinaldi G, Morello V, Gerbino A, Tomasino RM, Macaluso M, Surmacz E, Russo A", "evidence": [ { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ { "type": "PubMed", "id": "16447252", "url": "https://glygen.org/publication/PubMed/16447252" } ] }, { "title": "SOCS1: a potent and multifaceted regulator of cytokines and cell-mediated inflammation.", "journal": "Tissue antigens", "date": "2006", "authors": "Davey GM, Heath WR, Starr R", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "16451196", "url": "https://glygen.org/publication/PubMed/16451196" } ] }, { "title": "Prognostic significance of p53 mutation in suboptimally resected advanced ovarian carcinoma treated with the combination chemotherapy of paclitaxel and carboplatin.", "journal": "Cancer letters", "date": "2006", "authors": "Ueno Y, Enomoto T, Otsuki Y, Sugita N, Nakashima R, Yoshino K, Kuragaki C, Ueda Y, Aki T, Ikegami H, Yamazaki M, Ito K, Nagamatsu M, Nishizaki T, Asada M, Kameda T, Wakimoto A, Mizutani T, Yamada T, Murata Y", "evidence": [ { "database": "dbSNP", "id": "rs587782329", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs587782329" } ], "reference": [ { "type": "PubMed", "id": "16459017", "url": "https://glygen.org/publication/PubMed/16459017" } ] }, { "title": "Inhibition of the ATM/p53 signal transduction pathway by Kaposi's sarcoma-associated herpesvirus interferon regulatory factor 1.", "journal": "Journal of virology", "date": "2006", "authors": "Shin YC, Nakamura H, Liang X, Feng P, Chang H, Kowalik TF, Jung JU", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16474133", "url": "https://glygen.org/publication/PubMed/16474133" } ] }, { "title": "Molecular recognition of p53 and MDM2 by USP7/HAUSP.", "journal": "Nat. Struct. Mol. Biol.", "date": "2006", "authors": "Arrowsmith C.H., Wu T., Duan S., Frappier L., Sheng Y., Saridakis V., Sarkari F.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "Reactome", "id": "R-HSA-6804757", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804757" } ], "reference": [ { "type": "PubMed", "id": "16474402", "url": "https://glygen.org/publication/PubMed/16474402" } ] }, { "title": "Mutations of the P53 gene, including an intronic point mutation, in colorectal tumors.", "journal": "Biochem. Biophys. Res. Commun.", "date": "1991", "authors": "Sato T., Suzuki T., Yamazaki T., Shibata H., Ishioka C., Kanamaru R., Gamoh M., Wakui A.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "1647768", "url": "https://glygen.org/publication/PubMed/1647768" } ] }, { "title": "Expression of p53 enhances selenite-induced superoxide production and apoptosis in human prostate cancer cells.", "journal": "Cancer research", "date": "2006", "authors": "Zhao R, Xiang N, Domann FE, Zhong W", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16489034", "url": "https://glygen.org/publication/PubMed/16489034" } ] }, { "title": "Protein serine/threonine phosphatase-1 dephosphorylates p53 at Ser-15 and Ser-37 to modulate its transcriptional and apoptotic activities.", "journal": "Oncogene", "date": "2006", "authors": "Li DW, Liu JP, Schmid PC, Schlosser R, Feng H, Liu WB, Yan Q, Gong L, Sun SM, Deng M, Liu Y", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16501611", "url": "https://glygen.org/publication/PubMed/16501611" } ] }, { "title": "Cyclin D1 is transcriptionally regulated by and required for transformation by activated signal transducer and activator of transcription 3.", "journal": "Cancer research", "date": "2006", "authors": "Leslie K, Lang C, Devgan G, Azare J, Berishaj M, Gerald W, Kim YB, Paz K, Darnell JE, Albanese C, Sakamaki T, Pestell R, Bromberg J", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "16510571", "url": "https://glygen.org/publication/PubMed/16510571" } ] }, { "title": "Acetylation of p53 at lysine 373/382 by the histone deacetylase inhibitor depsipeptide induces expression of p21(Waf1/Cip1).", "journal": "Molecular and cellular biology", "date": "2006", "authors": "Zhao Y, Lu S, Wu L, Chai G, Wang H, Chen Y, Sun J, Yu Y, Zhou W, Zheng Q, Wu M, Otterson GA, Zhu WG", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16537920", "url": "https://glygen.org/publication/PubMed/16537920" } ] }, { "title": "Lack of prognostic impact of p53 gene mutation and p53 phosphorylation at serine 15 in multimodally treated adenocarcinomas of the gastroesophageal junction.", "journal": "Journal of cancer research and clinical oncology", "date": "2006", "authors": "Puhringer-Oppermann F, Stahl M, Keller G, Sarbia M", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16538517", "url": "https://glygen.org/publication/PubMed/16538517" } ] }, { "title": "Signaling mechanisms, interaction partners, and target genes of STAT6.", "journal": "Cytokine & growth factor reviews", "date": "2006", "authors": "Hebenstreit D, Wirnsberger G, Horejs-Hoeck J, Duschl A", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "16540365", "url": "https://glygen.org/publication/PubMed/16540365" } ] }, { "title": "CDK9 phosphorylates p53 on serine residues 33, 315 and 392.", "journal": "Cell cycle (Georgetown, Tex.)", "date": "2006", "authors": "Radhakrishnan SK, Gartel AL", "evidence": [ { "database": "iPTMnet", "id": "P04637-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637-1" } ], "reference": [ { "type": "PubMed", "id": "16552184", "url": "https://glygen.org/publication/PubMed/16552184" } ] }, { "title": "The p53 gene is very frequently mutated in small-cell lung cancer with a distinct nucleotide substitution pattern.", "journal": "Oncogene", "date": "1991", "authors": "Takahashi T, Takahashi T, Suzuki H, Hida T, Sekido Y, Ariyoshi Y, Ueda R", "evidence": [ { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ { "type": "PubMed", "id": "1656362", "url": "https://glygen.org/publication/PubMed/1656362" } ] }, { "title": "Endogenously produced ganglioside GM3 endows etoposide and doxorubicin resistance by up-regulating Bcl-2 expression in 3LL Lewis lung carcinoma cells.", "journal": "Glycobiology", "date": "2006", "authors": "Noguchi M, Kabayama K, Uemura S, Kang BW, Saito M, Igarashi Y, Inokuchi J", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16571667", "url": "https://glygen.org/publication/PubMed/16571667" } ] }, { "title": "Ranked prediction of p53 targets using hidden variable dynamic modeling.", "journal": "Genome biology", "date": "2006", "authors": "Barenco M, Tomescu D, Brewer D, Callard R, Stark J, Hubank M", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16584535", "url": "https://glygen.org/publication/PubMed/16584535" } ] }, { "title": "Gene mutation analysis of sinonasal lymphomas in Indonesia.", "journal": "Oncology reports", "date": "2006", "authors": "Kurniawan AN, Hongyo T, Hardjolukito ES, Ham MF, Takakuwa T, Kodariah R, Hoshida Y, Nomura T, Aozasa K", "evidence": [ { "database": "dbSNP", "id": "rs28934873", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934873" } ], "reference": [ { "type": "PubMed", "id": "16596195", "url": "https://glygen.org/publication/PubMed/16596195" } ] }, 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T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-beta 1.", "journal": "The Journal of experimental medicine", "date": "2006", "authors": "Kinjyo I, Inoue H, Hamano S, Fukuyama S, Yoshimura T, Koga K, Takaki H, Himeno K, Takaesu G, Kobayashi T, Yoshimura A", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "16606674", "url": "https://glygen.org/publication/PubMed/16606674" } ] }, { "title": "Targeting of p300/CREB binding protein coactivators by simian virus 40 is mediated through p53.", "journal": "Journal of virology", "date": "2006", "authors": "Borger DR, DeCaprio JA", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16611888", "url": "https://glygen.org/publication/PubMed/16611888" } ] }, { "title": "Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia.", "journal": "Nature reviews. Cancer", "date": "2006", "authors": "Grabher C, von Boehmer H, Look AT", "evidence": [ { "database": "Reactome", "id": "R-HSA-1912408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1912408" } ], "reference": [ { "type": "PubMed", "id": "16612405", "url": "https://glygen.org/publication/PubMed/16612405" } ] }, { "title": "Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks.", "journal": "The Journal of cell biology", "date": "2006", "authors": "Bekker-Jensen S, Lukas C, Kitagawa R, Melander F, Kastan MB, Bartek J, Lukas J", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16618811", "url": "https://glygen.org/publication/PubMed/16618811" } ] }, { "title": "Cell cycle arrest and apoptotic induction in LNCaP cells by MCS-C2, novel cyclin-dependent kinase inhibitor, through p53/p21WAF1/CIP1 pathway.", "journal": "Cancer science", "date": "2006", "authors": "Park HY, Kim MK, Moon SI, Cho YH, Lee CH", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16630142", "url": "https://glygen.org/publication/PubMed/16630142" } ] }, { "title": "Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) induces apoptosis and cell cycle arrest in A549 cells through p53 accumulation via c-Jun NH2-terminal kinase-mediated phosphorylation at serine 15 in vitro and in vivo.", "journal": "The Journal of pharmacology and experimental therapeutics", "date": "2006", "authors": "Hsu YL, Cho CY, Kuo PL, Huang YT, Lin CC", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16632641", "url": "https://glygen.org/publication/PubMed/16632641" } ] }, { "title": "Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning.", "journal": "The Journal of cell biology", "date": "2006", "authors": "Cai SL, Tee AR, Short JD, Bergeron JM, Kim J, Shen J, Guo R, Johnson CL, Kiguchi K, Walker CL", "evidence": [ { "database": "Reactome", "id": "R-HSA-5628897", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5628897" } ], "reference": [ { "type": "PubMed", "id": "16636147", "url": "https://glygen.org/publication/PubMed/16636147" } ] }, { "title": "Identification of an ataxia telangiectasia-mutated protein mediated surveillance system to regulate Bcl-2 overexpression.", "journal": "Oncogene", "date": "2006", "authors": "Zhang J, Lahti JM, Bruce A, He L, Parihar K, Fan C, Grenet J, Liu L, Kidd VJ, Cormier S, Tang D", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16636671", "url": "https://glygen.org/publication/PubMed/16636671" } ] }, { "title": "The carcinogenic role of oncogenic HPV and p53 gene mutation in cervical adenocarcinomas.", "journal": "Medical oncology (Northwood, London, England)", "date": "2006", "authors": "Andersson S, Hellstrom AC, Ren ZP, Wilander E", "evidence": [ { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ { "type": "PubMed", "id": "16645236", "url": "https://glygen.org/publication/PubMed/16645236" } ] }, { "title": "DNA damage-induced BARD1 phosphorylation is critical for the inhibition of messenger RNA processing by BRCA1/BARD1 complex.", "journal": "Cancer research", "date": "2006", "authors": "Kim HS, Li H, Cevher M, Parmelee A, Fonseca D, Kleiman FE, Lee SB", "evidence": [ { "database": "Reactome", "id": "R-HSA-5693565", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5693565" } ], "reference": [ { "type": "PubMed", "id": "16651405", 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"https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1131691034" } ], "reference": [ { "type": "PubMed", "id": "16696020", "url": "https://glygen.org/publication/PubMed/16696020" } ] }, { "title": "Differential promoter usage for insulin-like growth factor-II gene in Chinese hepatocellular carcinoma with hepatitis B virus infection.", "journal": "Cancer detection and prevention", "date": "2006", "authors": "Tang SH, Yang DH, Huang W, Zhou M, Zhou HK, Lu XH, Ye G", "evidence": [ { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ { "type": "PubMed", "id": "16697535", "url": "https://glygen.org/publication/PubMed/16697535" } ] }, { "title": "Nuclear receptor TLX prevents retinal dystrophy and recruits the corepressor atrophin1.", "journal": "Genes & development", "date": "2006", "authors": "Zhang CL, Zou Y, Yu RT, Gage FH, Evans RM", "evidence": [ { "database": "Reactome", "id": "R-HSA-8943724", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8943724" } ], "reference": [ { "type": "PubMed", "id": "16702404", "url": "https://glygen.org/publication/PubMed/16702404" } ] }, { "title": "The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines.", "journal": "FEBS J.", "date": "2006", "authors": "Lazo P.A., Vega F.M., Blanco S., Klimcakova L.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16704422", "url": "https://glygen.org/publication/PubMed/16704422" } ] }, { "title": "GAS41 is required for repression of the p53 tumor suppressor pathway during normal cellular proliferation.", "journal": "Molecular and cellular biology", "date": "2006", "authors": "Park JH, Roeder RG", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16705155", "url": "https://glygen.org/publication/PubMed/16705155" } ] }, { "title": "Identification of a novel germ line variant hotspot mutant p53-R175L in pediatric adrenal cortical carcinoma.", "journal": "Cancer research", "date": "2006", "authors": "West AN, Ribeiro RC, Jenkins J, Rodriguez-Galindo C, Figueiredo BC, Kriwacki R, Zambetti GP", "evidence": [ { "database": "Entrez", "id": "7157", "url": "https://www.ncbi.nlm.nih.gov/gene/7157" } ], "reference": [ { "type": "PubMed", "id": "16707427", "url": "https://glygen.org/publication/PubMed/16707427" } ] }, { "title": "Prostaglandin E2 stimulates p53 transactivational activity through specific serine 15 phosphorylation in human synovial fibroblasts. Role in suppression of c/EBP/NF-kappaB-mediated MEKK1-induced MMP-1 expression.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Faour WH, He Q, Mancini A, Jovanovic D, Antoniou J, Di Battista JA", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16714289", "url": "https://glygen.org/publication/PubMed/16714289" } ] }, { "title": "Phosphorylation and gene expression of p53 are not affected in human cells exposed to 2.1425 GHz band CW or W-CDMA modulated radiation allocated to mobile radio base stations.", "journal": "Bioelectromagnetics", "date": "2006", "authors": "Hirose H, Sakuma N, Kaji N, Suhara T, Sekijima M, Nojima T, Miyakoshi J", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16715525", "url": "https://glygen.org/publication/PubMed/16715525" } ] }, { "title": "Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate.", "journal": "The Journal of cell biology", "date": "2006", "authors": "Knights CD, Catania J, Di Giovanni S, Muratoglu S, Perez R, Swartzbeck A, Quong AA, Zhang X, Beerman T, Pestell RG, Avantaggiati ML", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16717128", "url": "https://glygen.org/publication/PubMed/16717128" } ] }, { "title": "Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa.", "journal": "Nature", "date": "1991", "authors": "Ozturk M., Kew M., Bressac B., Wands J.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "dbSNP", "id": "rs28934571", "url": 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Gurtner A, Gasbarri A, Ulivieri A, Del Prete F, Trovato M, Piaggio G, Bartolazzi A, Soddu S, Sciacchitano S", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16738336", "url": "https://glygen.org/publication/PubMed/16738336" } ] }, { "title": "Cdk9 phosphorylates p53 on serine 392 independently of CKII.", "journal": "Journal of cellular physiology", "date": "2006", "authors": "Claudio PP, Cui J, Ghafouri M, Mariano C, White MK, Safak M, Sheffield JB, Giordano A, Khalili K, Amini S, Sawaya BE", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16741955", "url": "https://glygen.org/publication/PubMed/16741955" } ] }, { "title": "p53-dependent inhibition of mammalian cell survival by a genetically selected peptide aptamer that targets the 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Cell physiology", "date": "2006", "authors": "Fontanesi F, Soto IC, Horn D, Barrientos A", "evidence": [ { "database": "Reactome", "id": "R-HSA-5628897", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5628897" } ], "reference": [ { "type": "PubMed", "id": "16760263", "url": "https://glygen.org/publication/PubMed/16760263" } ] }, { "title": "Gadd45a interacts with aurora-A and inhibits its kinase activity.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Shao S, Wang Y, Jin S, Song Y, Wang X, Fan W, Zhao Z, Fu M, Tong T, Dong L, Fan F, Xu N, Zhan Q", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804114", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804114" } ], "reference": [ { "type": "PubMed", "id": "16772293", "url": "https://glygen.org/publication/PubMed/16772293" } ] }, { "title": "Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase 2.", "journal": "Carcinogenesis", "date": "2006", "authors": "Tyagi A, Singh RP, Agarwal C, Agarwal R", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16777994", "url": "https://glygen.org/publication/PubMed/16777994" } ] }, { "title": "Forodesine, an inhibitor of purine nucleoside phosphorylase, induces apoptosis in chronic lymphocytic leukemia cells.", "journal": "Blood", "date": "2006", "authors": "Balakrishnan K, Nimmanapalli R, Ravandi F, Keating MJ, Gandhi V", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16778146", "url": "https://glygen.org/publication/PubMed/16778146" } ] }, { "title": "The modification of Sp3 isoforms by SUMOylation has differential effects on the SRC1A promoter.", "journal": "Gene", "date": "2006", "authors": "Ellis DJ, Dehm SM, Bonham K", "evidence": [ { "database": "Reactome", "id": "R-HSA-3232118", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3232118" } ], "reference": [ { "type": "PubMed", "id": "16781829", "url": "https://glygen.org/publication/PubMed/16781829" } ] }, { "title": "The p53-targeting human phosphatase hCdc14A interacts with the Cdk1/cyclin B complex and is differentially expressed in human cancers.", "journal": "Molecular cancer", "date": "2006", "authors": "Paulsen MT, Starks AM, Derheimer FA, Hanasoge S, Li L, Dixon JE, Ljungman M", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16784539", "url": "https://glygen.org/publication/PubMed/16784539" } ] }, { "title": "Structure of the Tfb1/p53 complex: Insights into the interaction between the p62/Tfb1 subunit of TFIIH and the activation domain of p53.", "journal": "Molecular cell", "date": "2006", "authors": "Di Lello P, Jenkins LMM, Jones TN, Nguyen BD, Hara T, Yamaguchi H, Dikeakos JD, Appella E, Legault P, Omichinski JG", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16793543", "url": "https://glygen.org/publication/PubMed/16793543" } ] }, { "title": "Structural basis of DNA recognition by p53 tetramers.", "journal": "Mol. Cell", "date": "2006", "authors": "Kessler N., Haran T.E., Kitayner M., Rabinovich D., Rozenberg H., Shakked Z., Shaulov L.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "16793544", "url": "https://glygen.org/publication/PubMed/16793544" } ] }, { "title": "Cleavage of Cdc6 by caspase-3 promotes ATM/ATR kinase-mediated apoptosis of HeLa cells.", "journal": "The Journal of cell biology", "date": "2006", "authors": "Yim H, Hwang IS, Choi JS, Chun KH, Jin YH, Ham YM, Lee KY, Lee SK", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16801388", "url": "https://glygen.org/publication/PubMed/16801388" } ] }, { "title": "Potent antiproliferative effects of resveratrol on human osteosarcoma SJSA1 cells: Novel cellular mechanisms involving the ERKs/p53 cascade.", "journal": "Free radical biology & medicine", "date": "2006", "authors": "Alkhalaf M, Jaffal S", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16814113", "url": "https://glygen.org/publication/PubMed/16814113" } ] }, { "title": "p73 and MDM2 confer the resistance of epidermoid carcinoma to cisplatin by blocking p53.", "journal": "Biochemical and biophysical research communications", "date": "2006", "authors": "Hayashi S, Ozaki T, Yoshida K, Hosoda M, Todo S, Akiyama S, Nakagawara A", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16815295", "url": "https://glygen.org/publication/PubMed/16815295" } ] }, { "title": "Time-dependent cytotoxicity induced by SJG-136 (NSC 694501): influence of the rate of interstrand cross-link formation on DNA damage signaling.", "journal": "Molecular cancer therapeutics", "date": "2006", "authors": "Arnould S, Spanswick VJ, Macpherson JS, Hartley JA, Thurston DE, Jodrell DI, Guichard SM", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16818520", "url": "https://glygen.org/publication/PubMed/16818520" } ] }, { "title": "Association of breast cancer outcome with status of p53 and MDM2 SNP309.", "journal": "Journal of the National Cancer Institute", "date": "2006", "authors": "Boersma BJ, Howe TM, Goodman JE, Yfantis HG, Lee DH, Chanock SJ, Ambs S", "evidence": [ { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ { "type": "PubMed", "id": "16818855", "url": "https://glygen.org/publication/PubMed/16818855" } ] }, { "title": "Coupling mitochondrial respiratory chain to cell death: an essential role of mitochondrial complex I in the interferon-beta and retinoic acid-induced cancer cell death.", "journal": "Cell death and differentiation", "date": "2007", "authors": "Huang G, Chen Y, Lu H, Cao X", "evidence": [ { "database": "Reactome", "id": "R-HSA-2559580", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2559580" } ], "reference": [ { "type": "PubMed", "id": "16826196", "url": "https://glygen.org/publication/PubMed/16826196" } ] }, { "title": "Identification of p53-46F as a super p53 with an enhanced ability to induce p53-dependent apoptosis.", "journal": "Cancer science", "date": "2006", "authors": "Nakamura Y, Futamura M, Kamino H, Yoshida K, Nakamura Y, Arakawa H", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16827804", "url": "https://glygen.org/publication/PubMed/16827804" } ] }, { "title": "TIGAR, a p53-inducible regulator of glycolysis and apoptosis.", "journal": "Cell", "date": "2006", "authors": "Bensaad K, Tsuruta A, Selak MA, Vidal MN, Nakano K, Bartrons R, Gottlieb E, Vousden KH", "evidence": [ { "database": "Reactome", "id": "R-HSA-5628897", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5628897" } ], "reference": [ { "type": "PubMed", "id": "16839880", "url": "https://glygen.org/publication/PubMed/16839880" } ] }, { "title": "Critical role for Daxx in regulating Mdm2.", "journal": "Nat. Cell Biol.", "date": "2006", "authors": "Tang J., Wang W., Yang X., Zhang J., Degenhardt Y.Y., El-Deiry W.S., Michaelson J.S., Qu L.K.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "Reactome", "id": "R-HSA-6804757", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804757" } ], "reference": [ { "type": "PubMed", "id": "16845383", "url": "https://glygen.org/publication/PubMed/16845383" } ] }, { "title": "Involvement of novel autophosphorylation sites in ATM activation.", "journal": "The EMBO journal", "date": "2006", "authors": "Kozlov SV, Graham ME, Peng C, Chen P, Robinson PJ, Lavin MF", "evidence": [ { "database": "Reactome", "id": "R-HSA-2559586", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2559586" } ], "reference": [ { "type": "PubMed", "id": "16858402", "url": "https://glygen.org/publication/PubMed/16858402" } ] }, { "title": "Inorganic selenium sensitizes prostate cancer cells to TRAIL-induced apoptosis through superoxide/p53/Bax-mediated activation of mitochondrial pathway.", "journal": "Molecular cancer therapeutics", "date": "2006", "authors": "Hu H, Jiang C, Schuster T, Li GX, Daniel PT, Lu J", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16891474", "url": "https://glygen.org/publication/PubMed/16891474" } ] }, { "title": "The potential role of DFNA5, a hearing impairment gene, in p53-mediated cellular response to DNA damage.", "journal": "Journal of human genetics", "date": "2006", "authors": "Masuda Y, Futamura M, Kamino H, Nakamura Y, Kitamura N, Ohnishi S, Miyamoto Y, Ichikawa H, Ohta T, Ohki M, Kiyono T, Egami H, Baba H, Arakawa H", "evidence": [ { "database": "Reactome", "id": "R-HSA-5620971", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5620971" } ], "reference": [ { "type": "PubMed", "id": "16897187", "url": "https://glygen.org/publication/PubMed/16897187" } ] }, { "title": "A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation.", "journal": "Cell", "date": "2006", "authors": "Narita M, Narita M, Krizhanovsky V, Nunez S, Chicas A, Hearn SA, Myers MP, Lowe SW", "evidence": [ { "database": "Reactome", "id": "R-HSA-2559584", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2559584" } ], "reference": [ { "type": "PubMed", "id": "16901784", "url": "https://glygen.org/publication/PubMed/16901784" } ] }, { "title": "A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response.", "journal": "Cell", "date": "2006", "authors": "Zhang D, Zaugg K, Mak TW, Elledge SJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "16901786", "url": "https://glygen.org/publication/PubMed/16901786" } ] }, { "title": "Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo.", "journal": "Nature", "date": "2006", "authors": "Pellegrini M, Celeste A, Difilippantonio S, Guo R, Wang W, Feigenbaum L, Nussenzweig A", "evidence": [ { "database": "iPTMnet", "id": "P04637-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637-1" } ], "reference": [ { "type": "PubMed", "id": "16906133", "url": "https://glygen.org/publication/PubMed/16906133" } ] }, { "title": "Cross talk between PML and p53 during poliovirus infection: implications for antiviral defense.", "journal": "Journal of virology", "date": "2006", "authors": "Pampin M, Simonin Y, Blondel B, Percherancier Y, Chelbi-Alix MK", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16912307", "url": "https://glygen.org/publication/PubMed/16912307" } ] }, { "title": "Resveratrol-induced cyclooxygenase-2 facilitates p53-dependent apoptosis in human breast cancer cells.", "journal": "Molecular cancer therapeutics", "date": "2006", "authors": "Tang HY, Shih A, Cao HJ, Davis FB, Davis PJ, Lin HY", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16928824", "url": "https://glygen.org/publication/PubMed/16928824" } ] }, { "title": "ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage.", "journal": "Science (New York, N.Y.)", "date": "2006", "authors": "Dornan D, Shimizu H, Mah A, Dudhela T, Eby M, O'rourke K, Seshagiri S, Dixit VM", "evidence": [ { "database": "Reactome", "id": "R-HSA-349425", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-349425" } ], "reference": [ { "type": "PubMed", "id": "16931761", "url": "https://glygen.org/publication/PubMed/16931761" } ] }, { "title": "Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines.", "journal": "Oncogene", "date": "1990", "authors": "Bartek J., Gannon J., Lane D.P., Iggo R.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "1694291", "url": "https://glygen.org/publication/PubMed/1694291" } ] }, { "title": "Nuclear PtdIns5P as a transducer of stress signaling: an in vivo role for PIP4Kbeta.", "journal": "Molecular cell", "date": "2006", "authors": "Jones DR, Bultsma Y, Keune WJ, Halstead JR, Elouarrat D, Mohammed S, Heck AJ, D'Santos CS, Divecha N", "evidence": [ { "database": "Reactome", "id": "R-HSA-6811555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811555" } ], "reference": [ { "type": "PubMed", "id": "16949365", "url": "https://glygen.org/publication/PubMed/16949365" } ] }, { "title": "The consensus coding sequences of human breast and colorectal cancers.", "journal": "Science", "date": "2006", "authors": "Bachman K.E., Barber T.D., Buckhaults P., Dawson D., Farrell C., Gazdar A.F., Hartigan J., Jones S., Kinzler K.W., Leary R.J., Lin J., Liu C., Mandelker D., Markowitz S.D., Meeh P., Papadopoulos N., Park B.H., Parmigiani G., Parsons D.W., Ptak J., Silliman N., Sjoeblom T., Szabo S., Velculescu V.E., Vogelstein B., Willis J., Willson J.K.V., Wood L.D., Wu L.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ { "type": "PubMed", "id": "16959974", "url": "https://glygen.org/publication/PubMed/16959974" } ] }, { "title": "Modification of p53 with O-linked N-acetylglucosamine regulates p53 activity and stability.", "journal": "Nature cell biology", "date": "2006", "authors": "Yang WH, Kim JE, Nam HW, Ju JW, Kim HS, Kim YS, Cho JW", "evidence": [ { "database": "O-GlcNAc Database", "id": "P04637", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P04637" }, { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16964247", "url": "https://glygen.org/publication/PubMed/16964247" } ] }, { "title": "FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP.", "journal": "Nature cell biology", "date": "2006", "authors": "van der Horst A, de Vries-Smits AM, Brenkman AB, van Triest MH, van den Broek N, Colland F, Maurice MM, Burgering BM", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "16964248", "url": "https://glygen.org/publication/PubMed/16964248" } ] }, { "title": "Small molecule inhibition of HDM2 leads to p53-mediated cell death in retinoblastoma cells.", "journal": "Archives of ophthalmology (Chicago, Ill. : 1960)", "date": "2006", "authors": "Elison JR, Cobrinik D, Claros N, Abramson DH, Lee TC", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16966622", "url": "https://glygen.org/publication/PubMed/16966622" } ] }, { "title": "Indole-3-carbinol mediated cell cycle arrest of LNCaP human prostate cancer cells requires the induced production of activated p53 tumor suppressor protein.", "journal": "Biochemical pharmacology", "date": "2006", "authors": "Hsu JC, Dev A, Wing A, Brew CT, Bjeldanes LF, Firestone GL", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16970927", "url": "https://glygen.org/publication/PubMed/16970927" } ] }, { "title": "Proteasome inhibitors potentiate etoposide-induced cell death in human astrocytoma cells bearing a mutated p53 isoform.", "journal": "The Journal of pharmacology and experimental therapeutics", "date": "2006", "authors": "Ceruti S, Mazzola A, Abbracchio MP", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "16971507", "url": "https://glygen.org/publication/PubMed/16971507" } ] }, { "title": "Expression of p53 and p53/47 are controlled by alternative mechanisms of messenger RNA translation initiation.", "journal": "Oncogene", "date": "2006", "authors": "Candeias MM, Powell DJ, Roubalova E, Apcher S, Bourougaa K, Vojtesek B, Bruzzoni-Giovanelli H, Fahraeus R", "evidence": [ { "database": "RefSeq", "id": "NP_001263628", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263628" }, { "database": "RefSeq", "id": "NP_000537", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000537" }, { "database": "RefSeq", "id": "NP_001263627", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263627" }, { "database": "RefSeq", "id": "NP_001263626", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263626" } ], "reference": [ { "type": "PubMed", "id": "16983332", "url": "https://glygen.org/publication/PubMed/16983332" } ] }, { "title": "p53 mutations in colorectal cancer.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1990", "authors": "Bodmer W.F., Rowan A., Lane D.P., Rodrigues N.R., Gannon J.V., Kerr I.B., Smith M.E.F.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "1699228", "url": "https://glygen.org/publication/PubMed/1699228" } ] }, { "title": "Epidermal growth factor receptor mutation in lung cancer are linked to bronchioloalveolar differentiation.", "journal": "The American journal of surgical pathology", "date": "2006", "authors": "Blons H, Cote JF, Le Corre D, Riquet M, Fabre-Guilevin E, Laurent-Puig P, Danel C", "evidence": [ { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ { "type": "PubMed", "id": "17001163", "url": "https://glygen.org/publication/PubMed/17001163" } ] }, { "title": "Structural basis for understanding oncogenic p53 mutations and designing rescue drugs.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2006", "authors": "Fersht A.R., Ang H.C., Joerger A.C.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "17015838", "url": "https://glygen.org/publication/PubMed/17015838" } ] }, { "title": "Dock4 is regulated by RhoG and promotes Rac-dependent cell migration.", "journal": "Experimental cell research", "date": "2006", "authors": "Hiramoto K, Negishi M, Katoh H", "evidence": [ { "database": "Reactome", "id": "R-HSA-983231", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983231" } ], "reference": [ { "type": "PubMed", "id": "17027967", "url": "https://glygen.org/publication/PubMed/17027967" } ] }, { "title": "Overexpression of BLCAP induces S phase arrest and apoptosis independent of p53 and NF-kappaB in human tongue carcinoma : BLCAP overexpression induces S phase arrest and apoptosis.", "journal": "Molecular and cellular biochemistry", "date": "2007", "authors": "Yao J, Duan L, Fan M, Yuan J, Wu X", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "17031575", "url": "https://glygen.org/publication/PubMed/17031575" } ] }, { "title": "The tumor suppressor p53 is bound to RNA by a stable covalent linkage.", "journal": "Mol. Cell. Biol.", "date": "1991", "authors": "Carroll R.B., Samad A.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "1705009", "url": "https://glygen.org/publication/PubMed/1705009" } ] }, { "title": "Avian reovirus activates a novel proapoptotic signal by linking Src to p53.", "journal": "Apoptosis : an international journal on programmed cell death", "date": "2006", "authors": "Ping-Yuan L, Hung-Jen L, Meng-Jiun L, Feng-Ling Y, Hsue-Yin H, Jeng-Woei L, Wen-Ling S", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "17051326", "url": "https://glygen.org/publication/PubMed/17051326" } ] }, { "title": "Interplay between human papilloma virus infection and p53 gene alterations in head and neck squamous cell carcinoma of an Indian patient population.", "journal": "Journal of clinical pathology", "date": "2007", "authors": "Mitra S, Banerjee S, Misra C, Singh RK, Roy A, Sengupta A, Panda CK, Roychoudhury S", "evidence": [ { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ { "type": "PubMed", "id": "17079356", "url": "https://glygen.org/publication/PubMed/17079356" } ] }, { "title": "Germ-line genetic variation of TP53 in osteosarcoma.", "journal": "Pediatric blood & cancer", "date": "2007", "authors": "Savage SA, Burdett L, Troisi R, Douglass C, Hoover RN, Chanock SJ", "evidence": [ { "database": "Entrez", "id": "7157", "url": "https://www.ncbi.nlm.nih.gov/gene/7157" } ], "reference": [ { "type": "PubMed", "id": "17096406", "url": "https://glygen.org/publication/PubMed/17096406" } ] }, { "title": "Flt3 Y591 duplication and Bcl-2 overexpression are detected in acute myeloid leukemia cells with high levels of phosphorylated wild-type p53.", "journal": "Blood", "date": 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Chem.", "date": "2007", "authors": "Wu L., Zhang Y., Zhao Y., Ma H., Gao Q., Band H., Band V., Griffin J.D., Wazer D.E., Bhat I., Dimri G., Gurumurthy C.B., Solomon A., Delmolino L.M., Germaniuk-Kurowska A., Katzman R.B., Kung A., Miele L., Reddi H.V., Stanculescu A., Zeng M.S.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "17317671", "url": "https://glygen.org/publication/PubMed/17317671" } ] }, { "title": "Homeodomain-interacting protein kinase 2 is the ionizing radiation-activated p53 serine 46 kinase and is regulated by ATM.", "journal": "Cancer research", "date": "2007", "authors": "Dauth I, Kruger J, Hofmann TG", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "17332358", "url": "https://glygen.org/publication/PubMed/17332358" } ] }, { "title": "Dynamic regulation of p53 subnuclear localization and senescence by MORC3.", "journal": "Mol. 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Santa F, Totaro MG, Prosperini E, Notarbartolo S, Testa G, Natoli G", "evidence": [ { "database": "Reactome", "id": "R-HSA-2559580", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2559580" } ], "reference": [ { "type": "PubMed", "id": "17825402", "url": "https://glygen.org/publication/PubMed/17825402" } ] }, { "title": "Structural requirements for the BARD1 tumor suppressor in chromosomal stability and homology-directed DNA repair.", "journal": "The Journal of biological chemistry", "date": "2007", "authors": "Laufer M, Nandula SV, Modi AP, Wang S, Jasin M, Murty VV, Ludwig T, Baer R", "evidence": [ { "database": "Reactome", "id": "R-HSA-5693565", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5693565" } ], "reference": [ { "type": "PubMed", "id": "17848578", "url": "https://glygen.org/publication/PubMed/17848578" } ] }, { "title": "Expression of securin promotes colorectal cancer cell death via a p53-independent pathway after radiation.", "journal": "Chemico-biological interactions", "date": "2007", "authors": "Chiu SJ, Hsu TS, Chao JI", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "17854787", "url": "https://glygen.org/publication/PubMed/17854787" } ] }, { "title": "Granzyme B-induced cell death involves induction of p53 tumor suppressor gene and its activation in tumor target cells.", "journal": "The Journal of biological chemistry", "date": "2007", "authors": "Meslin F, Thiery J, Richon C, Jalil A, Chouaib S", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "17855337", "url": "https://glygen.org/publication/PubMed/17855337" } ] }, { "title": "Orphan nuclear receptor TLX recruits histone deacetylases to repress transcription and regulate neural stem cell proliferation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2007", "authors": "Sun G, Yu RT, Evans RM, Shi Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-8943724", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8943724" } ], "reference": [ { "type": "PubMed", "id": "17873065", "url": "https://glygen.org/publication/PubMed/17873065" } ] }, { "title": "Fbw7 and Usp28 regulate myc protein stability in response to DNA damage.", "journal": "Cell cycle (Georgetown, Tex.)", "date": "2007", "authors": "Popov N, Herold S, Llamazares M, Schulein C, Eilers M", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "17873522", "url": "https://glygen.org/publication/PubMed/17873522" } ] }, { "title": "Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death.", "journal": "Molecular and cellular biology", "date": "2007", "authors": "Wang X, Nadarajah B, Robinson AC, McColl BW, Jin JW, Dajas-Bailador F, Boot-Handford RP, Tournier C", "evidence": [ { "database": "Reactome", "id": "R-HSA-2559580", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2559580" } ], "reference": [ { "type": "PubMed", "id": "17875933", "url": "https://glygen.org/publication/PubMed/17875933" } ] }, { "title": "Differential effects of hypoxia on etoposide-induced apoptosis according to the cancer cell lines.", "journal": "Molecular cancer", "date": "2007", "authors": "Cosse JP, Sermeus A, Vannuvel K, Ninane N, Raes M, Michiels C", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "17894897", "url": "https://glygen.org/publication/PubMed/17894897" } ] }, { "title": "Urodele p53 tolerates amino acid changes found in p53 variants linked to human cancer.", "journal": "BMC evolutionary biology", "date": "2007", "authors": "Villiard E, Brinkmann H, Moiseeva O, Mallette FA, Ferbeyre G, Roy S", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "17903248", "url": "https://glygen.org/publication/PubMed/17903248" } ] }, { "title": "SVH-B interacts directly with p53 and suppresses the transcriptional activity of p53.", "journal": "FEBS Lett.", "date": "2007", "authors": "Chen X., Zhou X., Hu G., Yang G., Huang R.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "17904127", "url": "https://glygen.org/publication/PubMed/17904127" } ] }, { "title": "The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP.", "journal": "Nature structural & molecular biology", "date": "2007", "authors": "Mantovani F, Tocco F, Girardini J, Smith P, Gasco M, Lu X, Crook T, Del Sal G", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "17906639", "url": "https://glygen.org/publication/PubMed/17906639" } ] }, { "title": "Molecular genetic analysis of p53 intratumoral heterogeneity in human astrocytic brain tumors.", "journal": "Journal of neuropathology and experimental neurology", "date": "2007", "authors": "Ren ZP, Olofsson T, Qu M, Hesselager G, Soussi T, Kalimo H, Smits A, Nister M", "evidence": [ { "database": "dbSNP", "id": "rs1131691034", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1131691034" } ], "reference": [ { "type": "PubMed", "id": "17917588", "url": "https://glygen.org/publication/PubMed/17917588" } ] }, { "title": "Akt promotes cisplatin resistance in human ovarian cancer cells through inhibition of p53 phosphorylation and nuclear function.", "journal": "International journal of cancer", "date": "2008", "authors": "Fraser M, Bai T, Tsang BK", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "17918180", "url": "https://glygen.org/publication/PubMed/17918180" } ] }, { "title": "Induction of G2/M arrest and apoptosis by sesquiterpene lactones in human melanoma cell lines.", "journal": "Biochemical pharmacology", "date": "2008", "authors": "Rozenblat S, Grossman S, Bergman M, Gottlieb H, Cohen Y, Dovrat S", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "17919456", "url": "https://glygen.org/publication/PubMed/17919456" } ] }, { "title": "DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity.", "journal": "Molecular and cellular biology", "date": "2007", "authors": "Sun Y, Xu Y, Roy K, Price BD", "evidence": [ { "database": "Reactome", "id": "R-HSA-2559586", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2559586" } ], "reference": [ { "type": "PubMed", "id": "17923702", "url": "https://glygen.org/publication/PubMed/17923702" } ] }, { "title": "Medulloblastomas overexpress the p53-inactivating oncogene WIP1/PPM1D.", "journal": "Journal of neuro-oncology", "date": "2008", "authors": "Castellino RC, De Bortoli M, Lu X, Moon SH, Nguyen TA, Shepard MA, Rao PH, Donehower LA, Kim JY", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "17932621", "url": "https://glygen.org/publication/PubMed/17932621" } ] }, { "title": "Anti-diol epoxide of benzo[a]pyrene induces transient Mdm2 and p53 Ser15 phosphorylation, while anti-diol epoxide of dibenzo[a,l]pyrene induces a nontransient p53 Ser15 phosphorylation.", "journal": "Molecular carcinogenesis", "date": "2008", "authors": "Paajarvi G, Jernstrom B, Seidel A, Stenius U", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "17932951", "url": "https://glygen.org/publication/PubMed/17932951" } ] }, { "title": "Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2007", "authors": "Zou J, Marjanovic J, Kisseleva MV, Wilson M, Majerus PW", "evidence": [ { "database": "Reactome", "id": "R-HSA-6811555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811555" } ], "reference": [ { "type": "PubMed", "id": "17940011", "url": "https://glygen.org/publication/PubMed/17940011" } ] }, { "title": "The predictive value of molecular markers (p53, EGFR, ATM, CHK2) in multimodally treated squamous cell carcinoma of the oesophagus.", "journal": "British journal of cancer", "date": "2007", "authors": "Sarbia M, Ott N, Puhringer-Oppermann F, Brucher BL", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "17940507", "url": "https://glygen.org/publication/PubMed/17940507" } ] }, { "title": "Kaposi's sarcoma-associated herpesvirus K-cyclin interacts with Cdk9 and stimulates Cdk9-mediated phosphorylation of p53 tumor suppressor.", "journal": "Journal of virology", "date": "2008", "authors": "Chang PC, Li M", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "17942552", "url": "https://glygen.org/publication/PubMed/17942552" } ] }, { "title": "Hbo1 Links p53-dependent stress signaling to DNA replication licensing.", "journal": "Mol. Cell. Biol.", "date": "2008", "authors": "Allis C.D., Sekiya T., Iizuka M., Smith M.M., Scrable H., Sarmento O.F.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "17954561", "url": "https://glygen.org/publication/PubMed/17954561" } ] }, { "title": "Modulation of the p53-MDM2 interaction by phosphorylation of Thr18: a computational study.", "journal": "Cell cycle (Georgetown, Tex.)", "date": "2007", "authors": "Lee HJ, Srinivasan D, Coomber D, Lane DP, Verma CS", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "17957142", "url": "https://glygen.org/publication/PubMed/17957142" } ] }, { "title": "[Posttranslational p53 phosphorylation in non small cell lung cancer cells after radio/chemotherapy].", "journal": "Pneumonologia i alergologia polska", "date": "2007", "authors": "Holownia A, Mroz RM, Kozlowski M, Chyczewska E, Laudanski J, Chyczewski L, Braszko JJ", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "17966099", "url": "https://glygen.org/publication/PubMed/17966099" } ] }, { "title": "Serine 15 phosphorylation of p53 directs its interaction with B56gamma and the tumor suppressor activity of B56gamma-specific protein phosphatase 2A.", "journal": "Mol. Cell. Biol.", "date": "2008", "authors": "Liu X., Cai X., Shouse G.P.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "17967874", "url": "https://glygen.org/publication/PubMed/17967874" } ] }, { "title": "Suppression of PTEN expression is essential for antiapoptosis and cellular transformation by oncogenic Ras.", "journal": "Cancer research", "date": "2007", "authors": "Vasudevan KM, Burikhanov R, Goswami A, Rangnekar VM", "evidence": [ { "database": "Reactome", "id": "R-HSA-8943724", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8943724" } ], "reference": [ { "type": "PubMed", "id": "17974977", "url": "https://glygen.org/publication/PubMed/17974977" } ] }, { "title": "An ATM- and Rad3-related (ATR) signaling pathway and a phosphorylation-acetylation cascade are involved in activation of p53/p21Waf1/Cip1 in response to 5-aza-2'-deoxycytidine treatment.", "journal": "The Journal of biological chemistry", "date": "2008", "authors": "Wang H, Zhao Y, Li L, McNutt MA, Wu L, Lu S, Yu Y, Zhou W, Feng J, Chai G, Yang Y, Zhu WG", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "17977830", "url": "https://glygen.org/publication/PubMed/17977830" } ] }, { "title": "Human USP3 is a chromatin modifier required for S phase progression and genome stability.", "journal": "Current biology : CB", "date": "2007", "authors": "Nicassio F, Corrado N, Vissers JH, Areces LB, Bergink S, Marteijn JA, Geverts B, Houtsmuller AB, Vermeulen W, Di Fiore PP, Citterio E", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "17980597", 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America", "date": "2007", "authors": "Wang B, Elledge SJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-5693565", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5693565" } ], "reference": [ { "type": "PubMed", "id": "18077395", "url": "https://glygen.org/publication/PubMed/18077395" } ] }, { "title": "Temporally distinct response of irradiated normal human fibroblasts and their bystander cells to energetic heavy ions.", "journal": "Mutation research", "date": "2008", "authors": "Hamada N, Ni M, Funayama T, Sakashita T, Kobayashi Y", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "18082226", "url": "https://glygen.org/publication/PubMed/18082226" } ] }, { "title": "Attenuation of DNA damage-induced p53 expression by arsenic: a possible mechanism for arsenic co-carcinogenesis.", "journal": "Molecular carcinogenesis", "date": "2008", "authors": "Shen S, Lee J, Weinfeld M, Le XC", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "18085531", "url": "https://glygen.org/publication/PubMed/18085531" } ] }, { "title": "Human herpesvirus 6B induces phosphorylation of p53 in its regulatory domain by a CK2- and p38-independent pathway.", "journal": "The Journal of general virology", "date": "2008", "authors": "Oster B, Bundgaard B, Hupp TR, Hollsberg P", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "18089732", "url": "https://glygen.org/publication/PubMed/18089732" } ] }, { "title": "Repression of PTEN phosphatase by Snail1 transcriptional factor during gamma radiation-induced apoptosis.", "journal": "Molecular and cellular biology", "date": "2008", "authors": "Escriva M, Peiro S, Herranz N, Villagrasa P, Dave N, Montserrat-Sentis B, Murray SA, Franci C, Gridley T, Virtanen I, Garcia de Herreros A", "evidence": [ { "database": "Reactome", "id": "R-HSA-8943724", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8943724" } ], "reference": [ { "type": "PubMed", "id": "18172008", "url": "https://glygen.org/publication/PubMed/18172008" } ] }, { "title": "Deubiquitylation of histone H2A activates transcriptional initiation via trans-histone cross-talk with H3K4 di- and trimethylation.", "journal": "Genes & development", "date": "2008", "authors": "Nakagawa T, Kajitani T, Togo S, Masuko N, Ohdan H, Hishikawa Y, Koji T, Matsuyama T, Ikura T, Muramatsu M, Ito T", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "18172164", "url": "https://glygen.org/publication/PubMed/18172164" } ] }, { "title": "A balance between NF-Y and p53 governs the pro- and anti-apoptotic transcriptional response.", "journal": "Nucleic acids research", "date": "2008", "authors": "Benatti P, Basile V, Merico D, Fantoni LI, Tagliafico E, Imbriano C", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "18187512", "url": "https://glygen.org/publication/PubMed/18187512" } ] }, { "title": "Suppression of protein expression of three avian reovirus S-class genome segments by RNA interference.", "journal": "Veterinary microbiology", "date": "2008", "authors": "Ji WT, Chulu JL, Lin FL, Li SK, Lee LH, Liu HJ", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "18191923", "url": "https://glygen.org/publication/PubMed/18191923" } ] }, { "title": "Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development.", "journal": "Developmental cell", "date": "2008", "authors": "Li J, Ran C, Li E, Gordon F, Comstock G, Siddiqui H, Cleghorn W, Chen HZ, Kornacker K, Liu CG, Pandit SK, Khanizadeh M, Weinstein M, Leone G, de Bruin A", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804116", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804116" } ], "reference": [ { "type": "PubMed", "id": "18194653", "url": "https://glygen.org/publication/PubMed/18194653" } ] }, { "title": "Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling.", "journal": "Genes & development", "date": "2008", "authors": "DeYoung MP, Horak P, Sofer A, Sgroi D, Ellisen LW", "evidence": [ { "database": "Reactome", "id": "R-HSA-5628897", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5628897" } ], "reference": [ { "type": "PubMed", "id": "18198340", "url": "https://glygen.org/publication/PubMed/18198340" } ] }, { "title": "DNA-damage response control of E2F7 and E2F8.", "journal": "EMBO reports", "date": "2008", "authors": "Zalmas LP, Zhao X, Graham AL, Fisher R, Reilly C, Coutts AS, La Thangue NB", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804116", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804116" } ], "reference": [ { "type": "PubMed", "id": "18202719", "url": "https://glygen.org/publication/PubMed/18202719" } ] }, { "title": "Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation.", "journal": "Mol. Cell", "date": "2008", "authors": "Chen X.L., Schlaepfer D.D., Lim Y., Vo T.T., Fisher S.J., Lim S.T., Hanson D.A., Howerton K., Ilic D., Larocque N.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "18206965", "url": "https://glygen.org/publication/PubMed/18206965" } ] }, { "title": "UVB-induced senescence in human keratinocytes requires a functional insulin-like growth factor-1 receptor and p53.", "journal": "Molecular biology of the cell", "date": "2008", "authors": "Lewis DA, Yi Q, Travers JB, Spandau DF", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "18216278", "url": "https://glygen.org/publication/PubMed/18216278" } ] }, { "title": "Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system.", "journal": "Cell", "date": "2008", "authors": "LaPorte SL, Juo ZS, Vaclavikova J, Colf LA, Qi X, Heller NM, Keegan AD, Garcia KC", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "18243101", "url": "https://glygen.org/publication/PubMed/18243101" } ] }, { "title": "PML enhances the regulation of p53 by CK1 in response to DNA damage.", "journal": "Oncogene", "date": "2008", "authors": "Alsheich-Bartok O, Haupt S, Alkalay-Snir I, Saito S, Appella E, Haupt Y", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "18246126", "url": "https://glygen.org/publication/PubMed/18246126" } ] }, { "title": "Detection of R337H, a germline TP53 mutation predisposing to multiple cancers, in asymptomatic women participating in a breast cancer screening program in Southern Brazil.", "journal": "Cancer letters", "date": "2008", "authors": "Palmero EI, Schuler-Faccini L, Caleffi M, Achatz MI, Olivier M, Martel-Planche G, Marcel V, Aguiar E, Giacomazzi J, Ewald IP, Giugliani R, Hainaut P, Ashton-Prolla P", "evidence": [ { "database": "Entrez", "id": "7157", "url": "https://www.ncbi.nlm.nih.gov/gene/7157" } ], "reference": [ { "type": "PubMed", "id": "18248785", "url": "https://glygen.org/publication/PubMed/18248785" } ] }, { "title": "Growth of persistent foci of DNA damage checkpoint factors is essential for amplification of G1 checkpoint signaling.", "journal": "DNA repair", "date": "2008", "authors": "Yamauchi M, Oka Y, Yamamoto M, Niimura K, Uchida M, Kodama S, Watanabe M, Sekine I, Yamashita S, Suzuki K", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "18248856", "url": "https://glygen.org/publication/PubMed/18248856" } ] }, { "title": "Sirt2 interacts with 14-3-3 beta/gamma and down-regulates the activity of p53.", "journal": "Biochem. Biophys. Res. Commun.", "date": "2008", "authors": "Baek K.H., Jin Y.H., Kang B.Y., Kim D.W., Kim Y.J., Lee K.Y., Yeo C.Y.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "18249187", "url": "https://glygen.org/publication/PubMed/18249187" } ] }, { "title": "The electrostatic surface of MDM2 modulates the specificity of its interaction with phosphorylated and unphosphorylated p53 peptides.", "journal": "Cell cycle (Georgetown, Tex.)", "date": "2008", "authors": "Brown CJ, Srinivasan D, Jun LH, Coomber D, Verma CS, Lane DP", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "18256546", "url": "https://glygen.org/publication/PubMed/18256546" } ] }, { "title": "Activated neutrophils induce an hMSH2-dependent G2/M checkpoint arrest and replication errors at a (CA)13-repeat in colon epithelial cells.", "journal": "Gut", "date": "2008", "authors": "Campregher C, Luciani MG, Gasche C", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "18272544", "url": "https://glygen.org/publication/PubMed/18272544" } ] }, { "title": "Biochemical and structural studies of ASPP proteins reveal differential binding to p53, p63, and p73.", "journal": "Structure (London, England : 1993)", "date": "2008", "authors": "Robinson RA, Lu X, Jones EY, Siebold C", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804759", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804759" } ], "reference": [ { "type": "PubMed", "id": "18275817", "url": "https://glygen.org/publication/PubMed/18275817" } ] }, { "title": "Apoptotic death induced by the cyclophosphamide analogue mafosfamide in human lymphoblastoid cells: contribution of DNA replication, transcription inhibition 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Lung cellular and molecular physiology", "date": "2008", "authors": "Kulkarni A, Das KC", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "18344416", "url": "https://glygen.org/publication/PubMed/18344416" } ] }, { "title": "Trimidox-induced apoptosis is mediated through induction of p53 in NALM-6 cells.", "journal": "Journal of pharmacological sciences", "date": "2008", "authors": "Kanno S, Ohtake T, Osanai Y, Kurauchi K, Ujibe M, Uwai K, Takeshita M, Satoh S, Ishikawa M", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "18344606", "url": "https://glygen.org/publication/PubMed/18344606" } ] }, { "title": "Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses.", "journal": "Nature neuroscience", "date": "2008", "authors": "Papadia S, Soriano FX, Leveille F, Martel MA, Dakin KA, Hansen HH, Kaindl A, Sifringer M, Fowler J, Stefovska V, McKenzie G, Craigon M, Corriveau R, Ghazal P, Horsburgh K, Yankner BA, Wyllie DJ, Ikonomidou C, Hardingham GE", "evidence": [ { "database": "Reactome", "id": "R-HSA-5628897", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5628897" } ], "reference": [ { "type": "PubMed", "id": "18344994", "url": "https://glygen.org/publication/PubMed/18344994" } ] }, { "title": "Drug 9AA reactivates p21/Waf1 and Inhibits HIV-1 progeny formation.", "journal": "Virology journal", "date": "2008", "authors": "Wu W, Kehn-Hall K, Pedati C, Zweier L, Castro I, Klase Z, Dowd CS, Dubrovsky L, Bukrinsky M, Kashanchi F", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "18348731", "url": "https://glygen.org/publication/PubMed/18348731" } ] }, { "title": "Twist is transcriptionally induced by activation of STAT3 and mediates STAT3 oncogenic function.", "journal": "The Journal of biological chemistry", "date": "2008", "authors": "Cheng GZ, Zhang WZ, Sun M, Wang Q, Coppola D, Mansour M, Xu LM, Costanzo C, Cheng JQ, Wang LH", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "18353781", "url": "https://glygen.org/publication/PubMed/18353781" } ] }, { "title": "Cyclobutane pyrimidine dimer formation and p53 production in human skin after repeated UV irradiation.", "journal": "Experimental dermatology", "date": "2008", "authors": "Yamaguchi Y, Coelho SG, Zmudzka BZ, Takahashi K, Beer JZ, Hearing VJ, Miller SA", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "18363705", "url": "https://glygen.org/publication/PubMed/18363705" } ] }, { "title": "p16(INK4a) translation suppressed by miR-24.", "journal": "PloS one", "date": "2008", "authors": "Lal A, Kim HH, Abdelmohsen K, Kuwano Y, Pullmann R Jr, Srikantan S, Subrahmanyam R, Martindale JL, Yang X, Ahmed F, Navarro F, Dykxhoorn D, Lieberman J, Gorospe M", "evidence": [ { "database": "Reactome", "id": "R-HSA-2559580", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2559580" } ], "reference": [ { "type": "PubMed", "id": "18365017", "url": "https://glygen.org/publication/PubMed/18365017" } ] }, { "title": "Hypoxia induces protection against etoposide-induced apoptosis: molecular profiling of changes in gene expression and transcription factor activity.", "journal": "Molecular cancer", "date": "2008", "authors": "Sermeus A, Cosse JP, Crespin M, Mainfroid V, de Longueville F, Ninane N, Raes M, Remacle J, Michiels C", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": 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JR, Burbano RR, Rey JA, Casartelli C", "evidence": [ { "database": "Entrez", "id": "7157", "url": "https://www.ncbi.nlm.nih.gov/gene/7157" } ], "reference": [ { "type": "PubMed", "id": "18393224", "url": "https://glygen.org/publication/PubMed/18393224" } ] }, { "title": "Overexpression of HIPK2 circumvents the blockade of apoptosis in chemoresistant ovarian cancer cells.", "journal": "Gynecologic oncology", "date": "2008", "authors": "Puca R, Nardinocchi L, Pistritto G, D'Orazi G", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "18395248", "url": "https://glygen.org/publication/PubMed/18395248" } ] }, { "title": "MAPK regulate p53-dependent cell death induced by benzo[a]pyrene: involvement of p53 phosphorylation and acetylation.", "journal": "Toxicology", "date": "2008", "authors": "Lin T, Mak NK, Yang MS", "evidence": [ { "database": "iPTMnet", "id": "P04637", 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Ospina E, Basso K, Nandula S, Murty V, Baer R, Ludwig T", "evidence": [ { "database": "Reactome", "id": "R-HSA-5693565", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5693565" } ], "reference": [ { "type": "PubMed", "id": "18443292", "url": "https://glygen.org/publication/PubMed/18443292" } ] }, { "title": "Resveratrol causes COX-2- and p53-dependent apoptosis in head and neck squamous cell cancer cells.", "journal": "Journal of cellular biochemistry", "date": "2008", "authors": "Lin HY, Sun M, Tang HY, Simone TM, Wu YH, Grandis JR, Cao HJ, Davis PJ, Davis FB", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "18446786", "url": "https://glygen.org/publication/PubMed/18446786" } ] }, { "title": "Regulation of Sox2 by STAT3 initiates commitment to the neural precursor cell fate.", "journal": "Stem cells and development", "date": "2008", "authors": "Foshay KM, Gallicano GI", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "18447642", "url": "https://glygen.org/publication/PubMed/18447642" } ] }, { "title": "Impact of low-frequency hotspot mutation R282Q on the structure of p53 DNA-binding domain as revealed by crystallography at 1.54 angstroms resolution.", "journal": "Acta Crystallogr. D", "date": "2008", "authors": "Luo R., Zhou Z., Ji X., Tan Y.H., Bai Y., Tu C., Shaw G.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "18453682", "url": "https://glygen.org/publication/PubMed/18453682" } ] }, { "title": "Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator.", "journal": "Cancer cell", "date": "2008", "authors": "Lain S, Hollick JJ, Campbell J, Staples OD, Higgins M, Aoubala M, McCarthy A, Appleyard V, Murray KE, Baker L, Thompson A, Mathers J, Holland SJ, Stark MJ, Pass G, Woods J, Lane DP, Westwood NJ", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "18455128", "url": "https://glygen.org/publication/PubMed/18455128" } ] }, { "title": "Regulation of IkappaB kinase-related kinases and antiviral responses by tumor suppressor CYLD.", "journal": "The Journal of biological chemistry", "date": "2008", "authors": "Zhang M, Wu X, Lee AJ, Jin W, Chang M, Wright A, Imaizumi T, Sun SC", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "18467330", "url": "https://glygen.org/publication/PubMed/18467330" } ] }, { "title": "p53 expression in concurrent chemoradiotherapy with docetaxel for head and neck squamous cell carcinoma.", "journal": "Auris, nasus, larynx", "date": "2009", "authors": "Oridate N, Homma A, Higuchi E, Suzuki F, Hatakeyama H, Mizumachi T, Furusawa J, Taki S, Furuta Y, Fukuda S", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "18472237", "url": "https://glygen.org/publication/PubMed/18472237" } ] }, { "title": "Docosahexaenoic acid induces apoptosis in colorectal carcinoma cells by modulating the PI3 kinase and p38 MAPK pathways.", "journal": "The Journal of nutritional biochemistry", "date": "2009", "authors": "Toit-Kohn JL, Louw L, Engelbrecht AM", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "18479896", "url": "https://glygen.org/publication/PubMed/18479896" } ] }, { "title": "Dephosphorylation of simian virus 40 large-T antigen and p53 protein by protein phosphatase 2A: inhibition by small-t antigen.", "journal": "Mol. Cell. Biol.", "date": "1991", "authors": "Mumby M.C., Walter G., Scheidtmann K.H., Rundell K.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "1848668", "url": "https://glygen.org/publication/PubMed/1848668" } ] }, { "title": "SALL4 is a key regulator of survival and apoptosis in human leukemic cells.", "journal": "Blood", "date": "2008", "authors": "Yang J, Chai L, Gao C, Fowles TC, Alipio Z, Dang H, Xu D, Fink LM, Ward DC, Ma Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-8943724", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8943724" } ], "reference": [ { "type": "PubMed", "id": "18487508", "url": "https://glygen.org/publication/PubMed/18487508" } ] }, { "title": "Cooperative roles of c-Abl and Cdk5 in regulation of p53 in response to oxidative stress.", "journal": "The Journal of biological chemistry", "date": "2008", "authors": "Lee JH, Jeong MW, Kim W, Choi YH, Kim KT", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804756", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804756" } ], "reference": [ { "type": "PubMed", "id": "18490454", "url": "https://glygen.org/publication/PubMed/18490454" } ] }, { "title": "Mutational hotspot in the p53 gene in human hepatocellular carcinomas.", "journal": "Nature", "date": "1991", "authors": "Sun T., Harris C.C., Hsu I.C., Metcalf R.A., Wang N.J., Welsh J.A.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ { "type": "PubMed", "id": "1849234", "url": "https://glygen.org/publication/PubMed/1849234" } ] }, { "title": "Critical role of p53 in histone deacetylase inhibitor-induced Epstein-Barr virus Zta expression.", "journal": "Journal of virology", "date": "2008", "authors": "Chang SS, Lo YC, Chua HH, Chiu HY, Tsai SC, Chen JY, Lo KW, Tsai CH", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "18495777", "url": "https://glygen.org/publication/PubMed/18495777" } ] }, { "title": "Loss of cyclin g1 expression in human uterine leiomyoma cells induces apoptosis.", "journal": "Reproductive sciences (Thousand Oaks, Calif.)", "date": "2008", "authors": "Kwon SH, Park JC, Ramachandran S, Cha SD, Kwon KY, Park JK, Park JW, Bae I, Cho CH", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "18497347", "url": "https://glygen.org/publication/PubMed/18497347" } ] }, { "title": "[Construction and expression of different mutants of human p53 and their effects on arsenite-induced cell apoptosis].", "journal": "Nan fang yi ke da xue xue bao = Journal of Southern Medical University", "date": "2008", "authors": "Liu AH, Gong XW, Wei J, Ming XY, Wang DA, Deng P, Luo SQ, Jiang Y", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "18504176", "url": "https://glygen.org/publication/PubMed/18504176" } ] }, { "title": "Kotomolide A arrests cell cycle progression and induces apoptosis through the induction of ATM/p53 and the initiation of mitochondrial system in human non-small cell lung cancer A549 cells.", "journal": "Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association", "date": "2008", "authors": "Chen CY, Hsu YL, Tsai YC, Kuo PL", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "18511169", "url": "https://glygen.org/publication/PubMed/18511169" } ] }, { "title": "Protein phosphatase-2A is a target of epigallocatechin-3-gallate and modulates p53-Bak apoptotic pathway.", "journal": "Cancer research", "date": "2008", "authors": "Qin J, Chen HG, Yan Q, Deng M, Liu J, Doerge S, Ma W, Dong Z, Li DW", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "18519674", "url": "https://glygen.org/publication/PubMed/18519674" } ] }, { "title": "Proteasome inhibitors enhance TRAIL-induced apoptosis through the intronic regulation of DR5: involvement of NF-kappa B and reactive oxygen species-mediated p53 activation.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2008", "authors": "Chen JJ, Chou CW, Chang YF, Chen CC", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], 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"journal": "Cell. Signal.", "date": "2008", "authors": "Zhang L., He F., Xie P., Lu K., Tian C., Xing G., Nie J., An L.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "18585004", "url": "https://glygen.org/publication/PubMed/18585004" } ] }, { "title": "Isoflavones and gamma irradiation inhibit cell growth in human salivary gland cells.", "journal": "Cancer letters", "date": "2008", "authors": "Katz J, Blake E, Medrano TA, Sun Y, Shiverick KT", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "18585854", "url": "https://glygen.org/publication/PubMed/18585854" } ] }, { "title": "Telomere dysfunction in human keratinocytes elicits senescence and a novel transcription profile.", "journal": "Experimental cell research", "date": "2008", "authors": "Minty F, Thurlow JK, Harrison PR, Parkinson EK", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "18589416", "url": "https://glygen.org/publication/PubMed/18589416" } ] }, { "title": "Changes in phosphorylation of histone H2A.X and p53 in response of peripheral blood lymphocytes to gamma irradiation.", "journal": "Acta biochimica Polonica", "date": "2008", "authors": "Vilasova Z, Rezacova M, Vavrova J, Tichy A, Vokurkova D, Zoelzer F, Rehakova Z, Osterreicher J, Lukasova E", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "18596987", "url": "https://glygen.org/publication/PubMed/18596987" } ] }, { "title": "Role for DYRK family kinases on regulation of apoptosis.", "journal": "Biochemical pharmacology", "date": "2008", "authors": "Yoshida K", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "18599021", "url": "https://glygen.org/publication/PubMed/18599021" } ] }, { "title": "The C/H3 domain of p300 is required to protect VRK1 and VRK2 from their downregulation induced by p53.", "journal": "PloS one", "date": "2008", "authors": "Valbuena A, Blanco S, Vega FM, Lazo PA", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "18612383", "url": "https://glygen.org/publication/PubMed/18612383" } ] }, { "title": "SUMO-modified Sp3 represses transcription by provoking local heterochromatic gene silencing.", "journal": "EMBO reports", "date": "2008", "authors": "Stielow B, Sapetschnig A, Wink C, Kruger I, Suske G", "evidence": [ { "database": "Reactome", "id": "R-HSA-3232118", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3232118" } ], "reference": [ { "type": "PubMed", "id": "18617891", "url": "https://glygen.org/publication/PubMed/18617891" } ] }, { "title": "Exosome secretion, including the DNA damage-induced p53-dependent secretory pathway, is severely compromised in TSAP6/Steap3-null mice.", "journal": "Cell death and differentiation", "date": "2008", "authors": "Lespagnol A, Duflaut D, Beekman C, Blanc L, Fiucci G, Marine JC, Vidal M, Amson R, Telerman A", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803204", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803204" } ], "reference": [ { "type": "PubMed", "id": "18617898", "url": "https://glygen.org/publication/PubMed/18617898" } ] }, { "title": "Vasopressin-inducible ubiquitin-specific protease 10 increases ENaC cell surface expression by deubiquitylating and stabilizing sorting nexin 3.", "journal": "American journal of physiology. Renal physiology", "date": "2008", "authors": "Boulkroun S, Ruffieux-Daidie D, Vitagliano JJ, Poirot O, Charles RP, Lagnaz D, Firsov D, Kellenberger S, Staub O", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "18632802", "url": "https://glygen.org/publication/PubMed/18632802" } ] }, { "title": "The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response.", "journal": "EMBO reports", "date": "2008", "authors": "Friedman CS, O'Donnell MA, Legarda-Addison D, Ng A, Cardenas WB, Yount JS, Moran TM, Basler CF, Komuro A, Horvath CM, Xavier R, Ting AT", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "18636086", "url": "https://glygen.org/publication/PubMed/18636086" } ] }, { "title": "Chk1 inhibition activates p53 through p38 MAPK in tetraploid cancer cells.", "journal": "Cell cycle (Georgetown, Tex.)", "date": "2008", "authors": "Vitale I, Senovilla L, Galluzzi L, Criollo A, Vivet S, Castedo M, Kroemer G", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "18642443", "url": "https://glygen.org/publication/PubMed/18642443" } ] }, { "title": "Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379.", "journal": "Molecular and cellular biology", "date": "2008", "authors": "Lovly CM, Yan L, Ryan CE, Takada S, Piwnica-Worms H", "evidence": [ { "database": "Reactome", "id": "R-HSA-5693565", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5693565" } ], "reference": [ { "type": "PubMed", "id": "18644861", "url": "https://glygen.org/publication/PubMed/18644861" } ] }, { "title": "Signal transducer and activator of transcription 3 is required for hypoxia-inducible factor-1alpha RNA expression in both tumor cells and tumor-associated myeloid cells.", "journal": "Molecular cancer research : MCR", "date": "2008", "authors": "Niu G, Briggs J, Deng J, Ma Y, Lee H, Kortylewski M, Kujawski M, Kay H, Cress WD, Jove R, Yu H", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "18644974", "url": "https://glygen.org/publication/PubMed/18644974" } ] }, { "title": "Targeted rescue of a destabilized mutant of p53 by an in silico screened drug.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2008", "authors": "Rutherford T.J., Veprintsev D.B., Fersht A.R., Boeckler F.M., Jaggi G., Joerger A.C.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "18650397", "url": "https://glygen.org/publication/PubMed/18650397" } ] }, { "title": "Cataloging and organizing p73 interactions in cell cycle arrest and apoptosis.", "journal": "Nucleic acids research", "date": "2008", "authors": "Tozluoglu M, Karaca E, Haliloglu T, Nussinov R", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "18660513", "url": "https://glygen.org/publication/PubMed/18660513" } ] }, { "title": "Selenocystine induces apoptosis of A375 human melanoma cells by activating ROS-mediated mitochondrial pathway and p53 phosphorylation.", "journal": "Cellular and molecular life sciences : CMLS", "date": "2008", "authors": "Chen T, Wong YS", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "18661100", "url": "https://glygen.org/publication/PubMed/18661100" } ] }, { "title": "A central role for CK1 in catalyzing phosphorylation of the p53 transactivation domain at serine 20 after HHV-6B viral infection.", "journal": "The Journal of biological chemistry", "date": "2008", "authors": "MacLaine NJ, Oster B, Bundgaard B, Fraser JA, Buckner C, Lazo PA, Meek DW, Hollsberg P, Hupp TR", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "18669630", "url": "https://glygen.org/publication/PubMed/18669630" } ] }, { "title": "Molecular interactions of ASPP1 and ASPP2 with the p53 protein family and the apoptotic promoters PUMA and Bax.", "journal": "Nucleic acids research", "date": "2008", "authors": "Patel S, George R, Autore F, Fraternali F, Ladbury JE, Nikolova PV", "evidence": [ { "database": "Reactome", "id": "R-HSA-139915", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-139915" } ], "reference": [ { "type": "PubMed", "id": "18676979", "url": "https://glygen.org/publication/PubMed/18676979" } ] }, { "title": "p53 gene mutations in Barrett's epithelium and esophageal cancer.", "journal": "Cancer Res.", "date": "1991", "authors": "Roth J.A., Casson A.G., Cleary K.R., Levin B., Mukhopadhyay T., Ro J.Y.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "1868473", "url": "https://glygen.org/publication/PubMed/1868473" } ] }, { "title": "NUPR1 interacts with p53, transcriptionally regulates p21 and rescues breast epithelial cells from doxorubicin-induced genotoxic stress.", "journal": "Curr. 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Baumann C, Bohringer M, Scheidtmann KH, Muller-Tidow C, Wiesmuller L", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "18697815", "url": "https://glygen.org/publication/PubMed/18697815" } ] }, { "title": "Deletions of BRCA1/2 and p53 R248W gain-of-function mutation suggest impaired homologous recombination repair in fragile histidine triad-negative sebaceous gland carcinomas.", "journal": "The British journal of dermatology", "date": "2008", "authors": "Becker K, Goldberg M, Helmbold P, Holbach LM, Loeffler KU, Ballhausen WG", "evidence": [ { "database": "Entrez", "id": "7157", "url": "https://www.ncbi.nlm.nih.gov/gene/7157" } ], "reference": [ { "type": "PubMed", "id": "18717684", "url": "https://glygen.org/publication/PubMed/18717684" } ] }, { "title": "15-deoxy-Delta(12,14)-prostaglandin J2 induces vascular endothelial cell apoptosis through the sequential 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Mol. Biol.", "date": "2009", "authors": "Kessler N., Frolow F., Rotter V., Brosh R., Diskin-Posner Y., Liran A., Rozenberg H., Shakked Z., Shimon L.J., Suad O.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "18996393", "url": "https://glygen.org/publication/PubMed/18996393" } ] }, { "title": "NFBD1/MDC1, 53BP1 and BRCA1 have both redundant and unique roles in the ATM pathway.", "journal": "Cell cycle (Georgetown, Tex.)", "date": "2008", "authors": "Wilson KA, Stern DF", "evidence": [ { "database": "Reactome", "id": "R-HSA-5693565", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5693565" } ], "reference": [ { "type": "PubMed", "id": "19001859", "url": "https://glygen.org/publication/PubMed/19001859" } ] }, { "title": "Arginine methylation regulates the p53 response.", "journal": "Nat. 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"http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "19095450", "url": "https://glygen.org/publication/PubMed/19095450" } ] }, { "title": "The Epstein-Barr virus replication and transcription activator, Rta/BRLF1, induces cellular senescence in epithelial cells.", "journal": "Cell cycle (Georgetown, Tex.)", "date": "2009", "authors": "Chen YL, Chen YJ, Tsai WH, Ko YC, Chen JY, Lin SF", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "19098430", "url": "https://glygen.org/publication/PubMed/19098430" } ] }, { "title": "Reduction of Orc6 expression sensitizes human colon cancer cells to 5-fluorouracil and cisplatin.", "journal": "PloS one", "date": "2008", "authors": "Gavin EJ, Song B, Wang Y, Xi Y, Ju J", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "19112505", "url": "https://glygen.org/publication/PubMed/19112505" } ] }, { "title": "Sestrin 2 is not a reductase for cysteine sulfinic acid of peroxiredoxins.", "journal": "Antioxidants & redox signaling", "date": "2009", "authors": "Woo HA, Bae SH, Park S, Rhee SG", "evidence": [ { "database": "Reactome", "id": "R-HSA-5628897", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5628897" } ], "reference": [ { "type": "PubMed", "id": "19113821", "url": "https://glygen.org/publication/PubMed/19113821" } ] }, { "title": "BRCA1-associated protein 1 interferes with BRCA1/BARD1 RING heterodimer activity.", "journal": "Cancer research", "date": "2009", "authors": "Nishikawa H, Wu W, Koike A, Kojima R, Gomi H, Fukuda M, Ohta T", "evidence": [ { "database": "Reactome", "id": "R-HSA-5693565", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5693565" } ], "reference": [ { "type": "PubMed", "id": "19117993", "url": "https://glygen.org/publication/PubMed/19117993" } ] }, { "title": "Phosphorylation of p53 is regulated by TPX2-Aurora A in xenopus oocytes.", "journal": "The Journal of biological chemistry", "date": "2009", "authors": "Pascreau G, Eckerdt F, Lewellyn AL, Prigent C, Maller JL", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804756", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804756" } ], "reference": [ { "type": "PubMed", "id": "19121998", "url": "https://glygen.org/publication/PubMed/19121998" } ] }, { "title": "Mechanism of interferon-gamma mediated down-regulation of interleukin-10 gene expression.", "journal": "Molecular immunology", "date": "2009", "authors": "Schaefer A, Unterberger C, Frankenberger M, Lohrum M, Staples KJ, Werner T, Stunnenberg H, Ziegler-Heitbrock L", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "19124156", "url": "https://glygen.org/publication/PubMed/19124156" } ] }, { "title": "FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination.", "journal": "Cell", "date": "2009", "authors": "Dupont S, Mamidi A, Cordenonsi M, Montagner M, Zacchigna L, Adorno M, Martello G, Stinchfield MJ, Soligo S, Morsut L, Inui M, Moro S, Modena N, Argenton F, Newfeld SJ, Piccolo S", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "19135894", "url": "https://glygen.org/publication/PubMed/19135894" } ] }, { "title": "Cooperative activation of the ATR checkpoint kinase by TopBP1 and damaged DNA.", "journal": "Nucleic acids research", "date": "2009", "authors": "Choi JH, Lindsey-Boltz LA, Sancar A", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "19139065", "url": "https://glygen.org/publication/PubMed/19139065" } ] }, { "title": "Modulation of gene expression in U251 glioblastoma cells by binding of mutant p53 R273H to intronic and intergenic sequences.", "journal": "Nucleic acids research", "date": "2009", "authors": "Brazdova M, Quante T, Togel L, Walter K, Loscher C, Tichy V, Cincarova L, Deppert W, Tolstonog GV", "evidence": [ { "database": "Entrez", "id": "7157", "url": "https://www.ncbi.nlm.nih.gov/gene/7157" } ], "reference": [ { "type": "PubMed", "id": "19139068", "url": "https://glygen.org/publication/PubMed/19139068" } ] }, { "title": "PP2A regulates ionizing radiation-induced apoptosis through Ser46 phosphorylation of p53.", "journal": "Molecular cancer therapeutics", "date": "2009", "authors": "Mi J, Bolesta E, Brautigan DL, Larner JM", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "19139122", "url": "https://glygen.org/publication/PubMed/19139122" } ] }, { "title": "Involvement of a p53-independent and post-transcriptional up-regulation for p21WAF/CIP1 following destabilization of the actin cytoskeleton.", "journal": "International journal of oncology", "date": "2009", "authors": "Lee YJ, Tsai CH, Hwang JJ, Chiu SJ, Sheu TJ, Keng PC", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "19148495", "url": "https://glygen.org/publication/PubMed/19148495" } ] }, { "title": "HPV-16E6 can induce multiple site phosphorylation of p53.", "journal": "Oncology reports", "date": "2009", "authors": "Zhang G, Sun L, Li Z, Si L, Song T, Huang C, Zhang W", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "19148510", "url": "https://glygen.org/publication/PubMed/19148510" } ] }, { "title": "NOTCH3 expression is induced in mural cells through an autoregulatory loop that requires endothelial-expressed JAGGED1.", "journal": "Circulation research", "date": "2009", "authors": "Liu H, Kennard S, Lilly B", "evidence": [ { "database": "Reactome", "id": "R-HSA-1912408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1912408" } ], "reference": [ { "type": "PubMed", "id": "19150886", "url": "https://glygen.org/publication/PubMed/19150886" } ] }, { "title": "p53 is frequently mutated in Burkitt's lymphoma cell lines.", "journal": "EMBO J.", "date": "1991", "authors": "Vousden K.H., Crook T., Shanahan F., Farrell P.J., Allan G.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "1915267", "url": "https://glygen.org/publication/PubMed/1915267" } ] }, { "title": "Identification of new p53 acetylation sites in COS-1 cells.", "journal": "Molecular & cellular proteomics : MCP", "date": "2009", "authors": "Joubel A, Chalkley RJ, Medzihradszky KF, Hondermarck H, Burlingame AL", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "19155208", "url": "https://glygen.org/publication/PubMed/19155208" } ] }, { "title": "Two distinct motifs within the p53 transactivation domain bind to the Taz2 domain of p300 and are differentially affected by phosphorylation.", "journal": "Biochemistry", "date": "2009", "authors": "Jenkins LM, Yamaguchi H, Hayashi R, Cherry S, Tropea JE, Miller M, Wlodawer A, Appella E, Mazur SJ", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "19166313", "url": "https://glygen.org/publication/PubMed/19166313" } ] }, { "title": "Protein phosphatase 5 regulates the function of 53BP1 after neocarzinostatin-induced DNA damage.", "journal": "The Journal of biological chemistry", "date": "2009", "authors": "Kang Y, Lee JH, Hoan NN, Sohn HM, Chang IY, You HJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-5693565", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5693565" } ], "reference": [ { "type": "PubMed", "id": "19176521", "url": "https://glygen.org/publication/PubMed/19176521" } ] }, { "title": "Regulation of the IL-23 and IL-12 balance by Stat3 signaling in the tumor microenvironment.", "journal": "Cancer cell", "date": "2009", "authors": "Kortylewski M, Xin H, Kujawski M, Lee H, Liu Y, Harris T, Drake C, Pardoll D, Yu H", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": 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"Reactome", "id": "R-HSA-5693565", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5693565" } ], "reference": [ { "type": "PubMed", "id": "19234442", "url": "https://glygen.org/publication/PubMed/19234442" } ] }, { "title": "p38alpha and p38gamma mediate oncogenic ras-induced senescence through differential mechanisms.", "journal": "The Journal of biological chemistry", "date": "2009", "authors": "Kwong J, Hong L, Liao R, Deng Q, Han J, Sun P", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "19251701", "url": "https://glygen.org/publication/PubMed/19251701" } ] }, { "title": "Ascochlorin activates p53 in a manner distinct from DNA damaging agents.", "journal": "International journal of cancer", "date": "2009", "authors": "Jeong JH, Nakajima H, Magae J, Furukawa C, Taki K, Otsuka K, Tomita M, Lee IS, Kim CH, Chang HW, Min KS, Park KK, Park KK, Chang YC", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "19253369", "url": "https://glygen.org/publication/PubMed/19253369" } ] }, { "title": "NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control.", "journal": "Genes & development", "date": "2009", "authors": "Wang B, Hurov K, Hofmann K, Elledge SJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-5693565", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5693565" } ], "reference": [ { "type": "PubMed", "id": "19261749", "url": "https://glygen.org/publication/PubMed/19261749" } ] }, { "title": "Structural basis for the antiproliferative activity of the Tob-hCaf1 complex.", "journal": "The Journal of biological chemistry", "date": "2009", "authors": "Horiuchi M, Takeuchi K, Noda N, Muroya N, Suzuki T, Nakamura T, Kawamura-Tsuzuku J, Takahasi K, Yamamoto T, Inagaki F", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804115", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804115" } ], "reference": [ { "type": "PubMed", "id": "19276069", "url": "https://glygen.org/publication/PubMed/19276069" } ] }, { "title": "Lapatinib, a dual inhibitor of ErbB-1/-2 receptors, enhances effects of combination chemotherapy in bladder cancer cells.", "journal": "International journal of oncology", "date": "2009", "authors": "McHugh LA, Sayan AE, Mejlvang J, Griffiths TR, Sun Y, Manson MM, Tulchinsky E, Mellon JK, Kriajevska M", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "19287975", "url": "https://glygen.org/publication/PubMed/19287975" } ] }, { "title": "Lnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617F.", "journal": "Journal of leukocyte biology", "date": "2009", "authors": "Gery S, Cao Q, Gueller S, Xing H, Tefferi A, Koeffler HP", "evidence": [ { "database": "Reactome", "id": "R-HSA-983231", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983231" } ], "reference": [ { "type": "PubMed", "id": "19293402", "url": "https://glygen.org/publication/PubMed/19293402" } ] }, { "title": "Heat shock factor-1 modulates p53 activity in the transcriptional response to DNA damage.", "journal": "Nucleic acids research", "date": "2009", "authors": "Logan IR, McNeill HV, Cook S, Lu X, Meek DW, Fuller-Pace FV, Lunec J, Robson CN", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "19295133", "url": "https://glygen.org/publication/PubMed/19295133" } ] }, { "title": "SMAR1 forms a ternary complex with p53-MDM2 and negatively regulates p53-mediated transcription.", "journal": "Journal of molecular biology", "date": "2009", "authors": "Pavithra L, Mukherjee S, Sreenath K, Kar S, Sakaguchi K, Roy S, Chattopadhyay S", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804759", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804759" }, { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "19303885", "url": "https://glygen.org/publication/PubMed/19303885" } ] }, { "title": "High molecular weight hyaluronan decreases UVB-induced apoptosis and inflammation in human epithelial corneal cells.", "journal": "Molecular vision", "date": "2009", "authors": "Pauloin T, Dutot M, Joly F, Warnet JM, Rat P", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "19325714", "url": "https://glygen.org/publication/PubMed/19325714" } ] }, { "title": "Antitumor activity of TMPyP4 interacting G-quadruplex in retinoblastoma cell lines.", "journal": "Experimental eye research", "date": "2009", "authors": "Mikami-Terao Y, Akiyama M, Yuza Y, Yanagisawa T, Yamada O, Kawano T, Agawa M, Ida H, Yamada H", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "19328784", "url": "https://glygen.org/publication/PubMed/19328784" } ] }, { "title": "TTK/hMps1 mediates the p53-dependent postmitotic checkpoint by phosphorylating p53 at Thr18.", "journal": "Molecular and cellular biology", "date": "2009", "authors": "Huang YF, Chang MD, Shieh SY", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "19332559", "url": "https://glygen.org/publication/PubMed/19332559" } ] }, { "title": "A germ line mutation in exon 5 of the p53 gene in an extended cancer family.", "journal": "Cancer Res.", "date": "1991", 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cells.", "journal": "The Journal of biological chemistry", "date": "2009", "authors": "Bomberger JM, Barnaby RL, Stanton BA", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "19398555", "url": "https://glygen.org/publication/PubMed/19398555" } ] }, { "title": "Artemis is a negative regulator of p53 in response to oxidative stress.", "journal": "Oncogene", "date": "2009", "authors": "Zhang X, Zhu Y, Geng L, Wang H, Legerski RJ", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "19398950", "url": "https://glygen.org/publication/PubMed/19398950" } ] }, { "title": "A novel triterpenoid isolated from the root bark of Ailanthus excelsa Roxb (Tree of Heaven), AECHL-1 as a potential anti-cancer agent.", "journal": "PloS one", "date": "2009", 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Biol. Chem.", "date": "2009", "authors": "Li H., Liu X., Yang X., Zhou Z., Wang W.H., Andrisani O., Deng A.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "19473992", "url": "https://glygen.org/publication/PubMed/19473992" } ] }, { "title": "The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo.", "journal": "Genes & development", "date": "2009", "authors": "Huse JT, Brennan C, Hambardzumyan D, Wee B, Pena J, Rouhanifard SH, Sohn-Lee C, le Sage C, Agami R, Tuschl T, Holland EC", "evidence": [ { "database": "Reactome", "id": "R-HSA-5628897", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5628897" } ], "reference": [ { "type": "PubMed", "id": "19487573", "url": "https://glygen.org/publication/PubMed/19487573" } ] }, { "title": "DN-R175H p53 mutation is more effective than p53 interference in inducing epithelial disorganization and activation of proliferation signals in human carcinoma cells: role of E-cadherin.", "journal": "International journal of cancer", "date": "2009", "authors": "Rieber M, Strasberg Rieber M", "evidence": [ { "database": "Entrez", "id": "7157", "url": "https://www.ncbi.nlm.nih.gov/gene/7157" } ], "reference": [ { "type": "PubMed", "id": "19507255", "url": "https://glygen.org/publication/PubMed/19507255" } ] }, { "title": "JFK, a Kelch domain-containing F-box protein, links the SCF complex to p53 regulation.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2009", "authors": "Li R., Sun L., Wang Y., Yang X., Zhang H., Li W., Yu W., Shi L., Yao X., Yi X., Liang J., Shang Y.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "19509332", "url": "https://glygen.org/publication/PubMed/19509332" } ] }, { "title": "Stabilising the DNA-binding domain of p53 by rational design of its hydrophobic core.", "journal": "Protein Eng. Des. Sel.", "date": "2009", "authors": "Freund S.M., Fersht A.R., Khoo K.H., Joerger A.C.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "19515728", "url": "https://glygen.org/publication/PubMed/19515728" } ] }, { "title": "MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway.", "journal": "The EMBO journal", "date": "2009", "authors": "Mancini F, Di Conza G, Pellegrino M, Rinaldo C, Prodosmo A, Giglio S, D'Agnano I, Florenzano F, Felicioni L, Buttitta F, Marchetti A, Sacchi A, Pontecorvi A, Soddu S, Moretti F", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "19521340", "url": "https://glygen.org/publication/PubMed/19521340" } ] }, { "title": "The role of TP53 PRO47SER and ARG72PRO single nucleotide polymorphisms in the susceptibility to bladder cancer.", "journal": "Urologic oncology", "date": "2011", "authors": "Santos LE, Guilhen AC, de Andrade RA, Sumi LG, Ward LS", "evidence": [ { "database": "Entrez", "id": "7157", "url": "https://www.ncbi.nlm.nih.gov/gene/7157" } ], "reference": [ { "type": "PubMed", "id": "19523860", "url": "https://glygen.org/publication/PubMed/19523860" } ] }, { "title": "Interaction between the transactivation domain of p53 and PC4 exemplifies acidic activation domains as single-stranded DNA mimics.", "journal": "The Journal of biological chemistry", "date": "2009", "authors": "Rajagopalan S, Andreeva A, Teufel DP, Freund SM, Fersht AR", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "19525231", "url": "https://glygen.org/publication/PubMed/19525231" } ] }, { "title": "Mitochondrial dysfunction contributes to oncogene-induced senescence.", "journal": "Molecular and cellular biology", "date": "2009", "authors": "Moiseeva O, Bourdeau V, Roux A, Deschenes-Simard X, Ferbeyre G", "evidence": [ { "database": "Reactome", "id": "R-HSA-2559580", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2559580" } ], "reference": [ { "type": "PubMed", "id": "19528227", "url": "https://glygen.org/publication/PubMed/19528227" } ] }, { "title": "High osmolality activates the G1 and G2 cell cycle checkpoints and affects the DNA integrity of nucleus pulposus intervertebral disc cells triggering an enhanced DNA repair response.", "journal": "DNA repair", "date": "2009", "authors": "Mavrogonatou E, Kletsas D", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "19535302", "url": "https://glygen.org/publication/PubMed/19535302" } ] }, { "title": "Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis.", "journal": "EMBO J.", "date": "2009", "authors": "Song J., Oh W., Camus S., Ghim J., Ha N.-C., Lane D.P., Lee E.-W., Lee M.-S., Yang M.-R.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "19536131", "url": "https://glygen.org/publication/PubMed/19536131" } ] }, { "title": "Shallot and licorice constituent isoliquiritigenin arrests cell cycle progression and induces apoptosis through the induction of ATM/p53 and initiation of the mitochondrial system in human cervical carcinoma HeLa cells.", "journal": "Molecular nutrition & food research", "date": "2009", "authors": "Hsu YL, Chia CC, Chen PJ, Huang SE, Huang SC, Kuo PL", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "19536869", "url": "https://glygen.org/publication/PubMed/19536869" } ] }, { "title": "BCL6 suppression of BCL2 via Miz1 and its disruption in diffuse large B cell lymphoma.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2009", "authors": "Saito M, Novak U, Piovan E, Basso K, Sumazin P, Schneider C, Crespo M, Shen Q, Bhagat G, Califano A, Chadburn A, Pasqualucci L, Dalla-Favera R", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803205", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803205" } ], "reference": [ { "type": "PubMed", "id": "19549844", "url": "https://glygen.org/publication/PubMed/19549844" } ] }, { "title": "Trim24 targets endogenous p53 for degradation.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2009", "authors": "Qin J., Jung S.Y., Barton M.C., Johnson R.L., Allton K., Bergmann A., Herz H.M., Jain A.K., Tsai W.W.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "19556538", "url": "https://glygen.org/publication/PubMed/19556538" } ] }, { "title": "Protein kinase phosphorylation site sequences and consensus specificity motifs: tabulations.", "journal": "Methods in enzymology", "date": "1991", "authors": "Pearson RB, Kemp BE", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "1956339", "url": "https://glygen.org/publication/PubMed/1956339" } ] }, { "title": "p53 Codon 72 polymorphism is associated with occurrence of cervical carcinoma in the Chinese population.", "journal": "Cancer letters", "date": "2010", "authors": "Ye F, Zhang J, Cheng Q, Shen J, Chen H", "evidence": [ { "database": "Entrez", "id": "7157", "url": "https://www.ncbi.nlm.nih.gov/gene/7157" } ], "reference": [ { "type": "PubMed", "id": "19576684", "url": "https://glygen.org/publication/PubMed/19576684" } ] }, { "title": "Inhibition of S-adenosylmethionine decarboxylase by inhibitor SAM486A connects polyamine metabolism with p53-Mdm2-Akt/protein kinase B regulation and apoptosis in neuroblastoma.", "journal": "Molecular cancer therapeutics", "date": "2009", "authors": "Koomoa DL, Borsics T, Feith DJ, Coleman CC, Wallick CJ, Gamper I, Pegg AE, Bachmann AS", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "19584241", "url": "https://glygen.org/publication/PubMed/19584241" } ] }, { "title": "Lysine acetylation targets protein complexes and co-regulates major cellular functions.", "journal": "Science", "date": "2009", "authors": "Choudhary C., Gnad F., Kumar C., Mann M., Nielsen M.L., Olsen J.V., Rehman M., Walther T.C.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "UniProtKB", "id": "A0A087X1Q1", "url": "https://www.uniprot.org/uniprot/A0A087X1Q1" } ], "reference": [ { "type": "PubMed", "id": "19608861", "url": "https://glygen.org/publication/PubMed/19608861" } ] }, { "title": "Active transcription of the human FAS/CD95/TNFRSF6 gene involves the p53 family.", "journal": "Biochemical and biophysical research communications", "date": "2009", "authors": "Schilling T, Schleithoff ES, Kairat A, Melino G, Stremmel W, Oren M, Krammer PH, Muller M", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803211", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803211" } ], "reference": [ { "type": "PubMed", "id": "19615968", "url": "https://glygen.org/publication/PubMed/19615968" } ] }, { "title": "SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis.", "journal": "Science signaling", "date": "2009", "authors": "Cheng H, Liu P, Wang ZC, Zou L, Santiago S, Garbitt V, Gjoerup OV, Iglehart JD, Miron A, Richardson AL, Hahn WC, Zhao JJ", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "19622832", "url": "https://glygen.org/publication/PubMed/19622832" } ] }, { "title": "Inhibition of ATR protein kinase activity by schisandrin B in DNA damage response.", "journal": "Nucleic acids research", "date": "2009", "authors": "Nishida H, Tatewaki N, Nakajima Y, Magara T, Ko KM, Hamamori Y, Konishi T", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "19625493", "url": "https://glygen.org/publication/PubMed/19625493" } ] }, { "title": "The Ste20-like kinase SLK promotes p53 transactivation and apoptosis.", "journal": "American journal of physiology. 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different from that of IE2-86 protein.", "journal": "J. Virol.", "date": "2009", "authors": "Zhang Z., Hwang E.S., Cai H., Huang D.Y., Huang E.S., Huong S.M., Cha C.Y.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "19776115", "url": "https://glygen.org/publication/PubMed/19776115" } ] }, { "title": "Structure and activation mechanism of the CHK2 DNA damage checkpoint kinase.", "journal": "Molecular cell", "date": "2009", "authors": "Cai Z, Chehab NH, Pavletich NP", "evidence": [ { "database": "Reactome", "id": "R-HSA-5693565", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5693565" } ], "reference": [ { "type": "PubMed", "id": "19782031", "url": "https://glygen.org/publication/PubMed/19782031" } ] }, { "title": "Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60.", "journal": "Nature cell biology", "date": "2009", "authors": "Sun Y, Jiang X, Xu Y, Ayrapetov MK, Moreau LA, Whetstine JR, Price BD", "evidence": [ { "database": "Reactome", "id": "R-HSA-2559586", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2559586" } ], "reference": [ { "type": "PubMed", "id": "19783983", "url": "https://glygen.org/publication/PubMed/19783983" } ] }, { "title": "Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms.", "journal": "Science", "date": "1990", "authors": "Kim D.H., Tainsky M.A., Friend S.H., Fraumeni J.F. Jr., Li F.P., Malkin D., Strong L.C., Gryka M.A., Bischoff F.Z., Kassel J., Nelson C.E.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "1978757", "url": "https://glygen.org/publication/PubMed/1978757" } ] }, { "title": "Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer. Lung Cancer Study Group.", "journal": "Oncogene", "date": "1990", "authors": "Chiba I, Takahashi T, Nau MM, D'Amico D, Curiel DT, Mitsudomi T, Buchhagen DL, Carbone D, Piantadosi S, Koga H, et al.", "evidence": [ { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ { "type": "PubMed", "id": "1979160", "url": "https://glygen.org/publication/PubMed/1979160" } ] }, { "title": "ATM activates p53 by regulating MDM2 oligomerization and E3 processivity.", "journal": "The EMBO journal", "date": "2009", "authors": "Cheng Q, Chen L, Li Z, Lane WS, Chen J", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804757", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804757" } ], "reference": [ { "type": "PubMed", "id": "19816404", "url": "https://glygen.org/publication/PubMed/19816404" } ] }, { "title": "The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER.", "journal": "Molecular cell", "date": "2009", "authors": "Ernst R, Mueller B, Ploegh HL, Schlieker C", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689896", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689896" } ], "reference": [ { "type": "PubMed", "id": "19818707", "url": "https://glygen.org/publication/PubMed/19818707" } ] }, { "title": "The position of the amino group on the benzene ring is critical for mesalamine's improvement of replication fidelity.", "journal": "Inflammatory bowel diseases", "date": "2010", "authors": "Campregher C, Luciani MG, Biesenbach P, Evstatiev R, Lyakhovich A, Gasche C", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "19821510", "url": "https://glygen.org/publication/PubMed/19821510" } ] }, { "title": "Role of sestrin2 in peroxide signaling in macrophages.", "journal": "FEBS letters", "date": "2009", "authors": "Essler S, Dehne N, Brune B", "evidence": [ { "database": "Reactome", "id": "R-HSA-5628897", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5628897" } ], "reference": [ { "type": "PubMed", "id": "19822145", "url": "https://glygen.org/publication/PubMed/19822145" } ] }, { "title": "Mutant p53 (G199V) gains antiapoptotic function through signal transducer and activator of transcription 3 in anaplastic thyroid cancer cells.", "journal": "Molecular cancer research : MCR", "date": "2009", "authors": "Kim TH, Lee SY, Rho JH, Jeong NY, Soung YH, Jo WS, Kang DY, Kim SH, Yoo YH", "evidence": [ { "database": "Entrez", "id": "7157", "url": "https://www.ncbi.nlm.nih.gov/gene/7157" } ], "reference": [ { "type": "PubMed", "id": "19825993", "url": "https://glygen.org/publication/PubMed/19825993" } ] }, { "title": "HIPK2 modulates p53 activity towards pro-apoptotic transcription.", "journal": "Molecular cancer", "date": "2009", "authors": "Puca R, Nardinocchi L, Sacchi A, Rechavi G, Givol D, D'Orazi G", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "19828042", "url": "https://glygen.org/publication/PubMed/19828042" } ] }, { "title": "Reconstitution of human claspin-mediated phosphorylation of Chk1 by the ATR (ataxia telangiectasia-mutated and rad3-related) checkpoint kinase.", "journal": "The Journal of biological chemistry", "date": "2009", "authors": "Lindsey-Boltz LA, Sercin O, Choi JH, Sancar A", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "19828454", "url": "https://glygen.org/publication/PubMed/19828454" } ] }, { "title": "Polo-like kinase-1 phosphorylates MDM2 at Ser260 and stimulates MDM2-mediated p53 turnover.", "journal": "FEBS letters", "date": "2009", "authors": "Dias SS, Hogan C, Ochocka AM, Meek DW", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "19833129", "url": "https://glygen.org/publication/PubMed/19833129" } ] }, { "title": "The receptor for advanced glycation end products (RAGE) sustains autophagy and limits apoptosis, promoting pancreatic tumor cell survival.", "journal": "Cell death and differentiation", "date": "2010", "authors": "Kang R, Tang D, Schapiro NE, Livesey KM, Farkas A, Loughran P, Bierhaus A, Lotze MT, Zeh HJ", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "19834494", "url": "https://glygen.org/publication/PubMed/19834494" } ] }, { "title": "MTA1 coregulator regulates p53 stability and function.", "journal": "J. Biol. Chem.", "date": "2009", "authors": "Wu X., Zhang Y., Kumar R., Rayala S.K., Li D.Q., Pakala S.B., Divijendra Natha Reddy S.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "19837670", "url": "https://glygen.org/publication/PubMed/19837670" } ] }, { "title": "MdmX is a substrate for the deubiquitinating enzyme USP2a.", "journal": "Oncogene", "date": "2010", "authors": "Allende-Vega N, Sparks A, Lane DP, Saville MK", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "19838211", "url": "https://glygen.org/publication/PubMed/19838211" } ] }, { "title": "Role of p53/FAK association and p53Ser46 phosphorylation in staurosporine-mediated apoptosis: wild type versus mutant p53-R175H.", "journal": "FEBS letters", "date": "2009", "authors": "Fanucchi S, Veale RB", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "19857493", "url": "https://glygen.org/publication/PubMed/19857493" } ] }, { "title": "Genomic screening for genes upregulated by demethylation revealed novel targets of epigenetic silencing in breast cancer.", "journal": "Breast cancer research and treatment", "date": "2010", "authors": "Fujikane T, Nishikawa N, Toyota M, Suzuki H, Nojima M, Maruyama R, Ashida M, Ohe-Toyota M, Kai M, Nishidate T, Sasaki Y, Ohmura T, Hirata K, Tokino T", "evidence": [ { "database": "Reactome", "id": "R-HSA-5620971", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5620971" } ], "reference": [ { "type": "PubMed", "id": "19859801", "url": "https://glygen.org/publication/PubMed/19859801" } ] }, { "title": "USP11 negatively regulates TNFalpha-induced NF-kappaB activation by targeting on IkappaBalpha.", "journal": "Cellular signalling", "date": "2010", "authors": "Sun W, Tan X, Shi Y, Xu G, Mao R, Gu X, Fan Y, Yu Y, Burlingame S, Zhang H, Rednam SP, Lu X, Zhang T, Fu S, Cao G, Qin J, Yang J", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "19874889", "url": "https://glygen.org/publication/PubMed/19874889" } ] }, { "title": "Pyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survival.", "journal": "J. Biol. Chem.", "date": "2010", "authors": "Chen X.L., Schlaepfer D.D., Lim Y., Lim S.T., Miller N.L., Nam J.O.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "19880522", "url": "https://glygen.org/publication/PubMed/19880522" } ] }, { "title": "Inhibitory role of cAMP on doxorubicin-induced apoptosis in pre-B ALL cells through dephosphorylation of p53 serine residues.", "journal": "Apoptosis : an international journal on programmed cell death", "date": "2010", "authors": "Safa M, Kazemi A, Zand H, Azarkeivan A, Zaker F, Hayat P", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "19882354", "url": "https://glygen.org/publication/PubMed/19882354" } ] }, { "title": "The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells.", "journal": "The Journal of clinical investigation", "date": "2009", "authors": "Song LB, Li J, Liao WT, Feng Y, Yu CP, Hu LJ, Kong QL, Xu LH, Zhang X, Liu WL, Li MZ, Zhang L, Kang TB, Fu LW, Huang WL, Xia YF, Tsao SW, Li M, Band V, Band H, Shi QH, Zeng YX, Zeng MS", "evidence": [ { "database": "Reactome", "id": "R-HSA-8943724", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8943724" } ], "reference": [ { "type": "PubMed", "id": "19884659", "url": "https://glygen.org/publication/PubMed/19884659" } ] }, { "title": "Mitochondrial MDM4 (MDMX): an unpredicted role in the p53-mediated intrinsic apoptotic pathway.", "journal": "Cell cycle (Georgetown, Tex.)", "date": "2009", "authors": "Mancini F, Moretti F", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "19887911", "url": "https://glygen.org/publication/PubMed/19887911" } ] }, { "title": "Breast cancer amplified sequence 2, a novel negative regulator of the p53 tumor suppressor.", "journal": "Cancer research", "date": "2009", "authors": "Kuo PC, Tsao YP, Chang HW, Chen PH, Huang CW, Lin ST, Weng YT, Tsai TC, Shieh SY, Chen SL", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "19903847", "url": "https://glygen.org/publication/PubMed/19903847" } ] }, { "title": "Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1.", "journal": "The Journal of biological chemistry", "date": "2010", "authors": "Xu G, Tan X, Wang H, Sun W, Shi Y, Burlingame S, Gu X, Cao G, Zhang T, Qin J, Yang J", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "19910467", "url": "https://glygen.org/publication/PubMed/19910467" } ] }, { "title": "Folding of tetrameric p53: oligomerization and tumorigenic mutations induce misfolding and loss of function.", "journal": "Journal of molecular biology", "date": "2010", "authors": "Lubin DJ, Butler JS, Loh SN", "evidence": [ { "database": "Reactome", "id": "R-HSA-9723905", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9723905" } ], "reference": [ { "type": "PubMed", "id": "19913028", "url": "https://glygen.org/publication/PubMed/19913028" } ] }, { "title": "Elevated expression of p53 gain-of-function mutation R175H in endometrial cancer cells can increase the invasive phenotypes by activation of the EGFR/PI3K/AKT pathway.", "journal": "Molecular cancer", "date": "2009", "authors": "Dong P, Xu Z, Jia N, Li D, Feng Y", "evidence": [ { "database": "Entrez", "id": "7157", "url": "https://www.ncbi.nlm.nih.gov/gene/7157" } ], "reference": [ { "type": "PubMed", "id": "19917135", "url": "https://glygen.org/publication/PubMed/19917135" } ] }, { "title": "Phosphorylation of serine 392 in p53 is a common and integral event during p53 induction by diverse stimuli.", "journal": "Cellular signalling", "date": "2010", "authors": "Cox ML, Meek DW", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "19932175", "url": "https://glygen.org/publication/PubMed/19932175" } ] }, { "title": "Mechanistic differences in the transcriptional activation of p53 by 14-3-3 isoforms.", "journal": "Nucleic acids research", "date": "2010", "authors": "Rajagopalan S, Sade RS, Townsley FM, Fersht AR", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "19933256", "url": "https://glygen.org/publication/PubMed/19933256" } ] }, { "title": "Imatinib mesylate induces cisplatin hypersensitivity in Bcr-Abl+ cells by differential modulation of p53 transcriptional and proapoptotic activity.", "journal": "Cancer research", "date": "2009", "authors": "Skorta I, Oren M, Markwardt C, Gutekunst M, Aulitzky WE, van der Kuip H", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "19934315", "url": "https://glygen.org/publication/PubMed/19934315" } ] }, { "title": "Essential role of mitochondria in apoptosis of cancer cells induced by the marine alkaloid Lamellarin D.", "journal": "Molecular cancer therapeutics", "date": "2009", "authors": "Ballot C, Kluza J, Martoriati A, Nyman U, Formstecher P, Joseph B, Bailly C, Marchetti P", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "19952118", "url": "https://glygen.org/publication/PubMed/19952118" } ] }, { "title": "24-hydroxyursolic acid from the leaves of the Diospyros kaki (Persimmon) induces apoptosis by activation of AMP-activated protein kinase.", "journal": "Planta medica", "date": "2010", "authors": "Khanal P, Oh WK, Thuong PT, Cho SD, Choi HS", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "19960411", "url": "https://glygen.org/publication/PubMed/19960411" } ] }, { "title": "ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage.", "journal": "The Journal of biological chemistry", "date": "2010", "authors": "Taira N, Yamamoto H, Yamaguchi T, Miki Y, Yoshida K", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804756", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804756" }, { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "19965871", "url": "https://glygen.org/publication/PubMed/19965871" } ] }, { "title": "Characterization of a frequent polymorphism in the coding sequence of the Tp53 gene in colonic cancer patients and a control population.", "journal": "Hum. Genet.", "date": "1991", "authors": "Laurent-Puig P., Thomas G., Olschwang S., Salmon R.-J., Vassal A.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "1999338", "url": "https://glygen.org/publication/PubMed/1999338" } ] }, { "title": "Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6.", "journal": "The Journal of biological chemistry", "date": "2010", "authors": "Li S, Zheng H, Mao AP, Zhong B, Li Y, Liu Y, Gao Y, Ran Y, Tien P, Shu HB", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689896", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689896" } ], "reference": [ { "type": "PubMed", "id": "19996094", "url": "https://glygen.org/publication/PubMed/19996094" } ] }, { "title": "Irradiation with carbon ion beams induces apoptosis, autophagy, and cellular senescence in a human glioma-derived cell line.", "journal": "International journal of radiation oncology, biology, physics", "date": "2010", "authors": "Jinno-Oue A, Shimizu N, Hamada N, Wada S, Tanaka A, Shinagawa M, Ohtsuki T, Mori T, Saha MN, Hoque AS, Islam S, Kogure K, Funayama T, Kobayashi Y, Hoshino H", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "20005456", "url": "https://glygen.org/publication/PubMed/20005456" } ] }, { "title": "SOCS1 links cytokine signaling to p53 and senescence.", "journal": "Molecular cell", "date": "2009", "authors": "Calabrese V, Mallette FA, Deschenes-Simard X, Ramanathan S, Gagnon J, Moores A, Ilangumaran S, Ferbeyre G", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "20005840", "url": "https://glygen.org/publication/PubMed/20005840" } ] }, { "title": "Expression of p53 protein phosphorylated at serine 20 and serine 392 in malignant and benign ovarian neoplasms: correlation with clinicopathological parameters of tumors.", "journal": "International journal of gynecological cancer : official journal of the International Gynecological Cancer Society", "date": "2009", "authors": "Bar JK, Slomska I, Rabczynki J, Noga L, Grybos M", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "20009884", "url": "https://glygen.org/publication/PubMed/20009884" } ] }, { "title": "Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks.", "journal": "Nature", "date": "2009", "authors": "Galanty Y, Belotserkovskaya R, Coates J, Polo S, Miller KM, Jackson SP", "evidence": [ { "database": "Reactome", "id": "R-HSA-3232118", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3232118" } ], "reference": [ { "type": "PubMed", "id": "20016603", "url": "https://glygen.org/publication/PubMed/20016603" } ] }, { "title": "Kaempferol induced the apoptosis via cell cycle arrest in human breast cancer MDA-MB-453 cells.", "journal": "Nutrition research and practice", "date": "2008", "authors": "Choi EJ, Ahn WS", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "20016737", "url": "https://glygen.org/publication/PubMed/20016737" } ] }, { "title": "Hypoxia suppresses chemotherapeutic drug-induced p53 Serine 46 phosphorylation by triggering HIPK2 degradation.", "journal": "Cancer letters", "date": "2010", "authors": "Moehlenbrink J, Bitomsky N, Hofmann TG", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "20018442", "url": "https://glygen.org/publication/PubMed/20018442" } ] }, { "title": "Human GTSE-1 regulates p21(CIP1/WAF1) stability conferring resistance to paclitaxel treatment.", "journal": "The Journal of biological chemistry", "date": "2010", "authors": "Bublik DR, Scolz M, Triolo G, Monte M, Schneider C", "evidence": [ { "database": "Reactome", "id": "R-HSA-8852276", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8852276" } ], "reference": [ { "type": "PubMed", "id": "20018861", "url": "https://glygen.org/publication/PubMed/20018861" } ] }, { "title": "HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes.", "journal": "Nature cell biology", "date": "2010", "authors": "Bekker-Jensen S, Rendtlew Danielsen J, Fugger K, Gromova I, Nerstedt A, Lukas C, Bartek J, Lukas J, Mailand N", "evidence": [ { "database": "Reactome", "id": "R-HSA-5693565", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5693565" } ], "reference": [ { "type": "PubMed", "id": "20023648", "url": "https://glygen.org/publication/PubMed/20023648" } ] }, { "title": "Mechanism of diepoxybutane-induced p53 regulation in human cells.", "journal": "Journal of biochemical and molecular toxicology", "date": "2009", "authors": "Yadavilli S, Chen Z, Albrecht T, Muganda PM", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "20024960", "url": "https://glygen.org/publication/PubMed/20024960" } ] }, { "title": "VentX, a novel lymphoid-enhancing factor/T-cell factor-associated transcription repressor, is a putative tumor suppressor.", "journal": "Cancer research", "date": "2010", "authors": "Gao H, Le Y, Wu X, Silberstein LE, Giese RW, Zhu Z", "evidence": [ { "database": "Reactome", "id": "R-HSA-8853884", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8853884" } ], "reference": [ { "type": "PubMed", "id": "20028861", "url": "https://glygen.org/publication/PubMed/20028861" } ] }, { "title": "Isoform specific phosphorylation of p53 by protein kinase CK1.", "journal": "Cell. Mol. Life Sci.", "date": "2010", "authors": "Pinna L.A., Marin O., Cozza G., Bustos V.H., Sarno S., Venerando A.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "20041275", "url": "https://glygen.org/publication/PubMed/20041275" } ] }, { "title": "Indole-3-carbinol induces apoptosis through p53 and activation of caspase-8 pathway in lung cancer A549 cells.", "journal": "Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association", "date": "2010", "authors": "Choi HS, Cho MC, Lee HG, Yoon DY", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "20060030", "url": "https://glygen.org/publication/PubMed/20060030" } ] }, { "title": "Coordinated regulation of p53 apoptotic targets BAX and PUMA by SMAR1 through an identical MAR element.", "journal": "The EMBO journal", "date": "2010", "authors": "Sinha S, Malonia SK, Mittal SP, Singh K, Kadreppa S, Kamat R, Mukhopadhyaya R, Pal JK, Chattopadhyay S", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804759", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804759" } ], "reference": [ { "type": "PubMed", "id": "20075864", "url": "https://glygen.org/publication/PubMed/20075864" } ] }, { "title": "Integrative genome analysis reveals an oncomir/oncogene cluster regulating glioblastoma survivorship.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2010", "authors": "Kim H, Huang W, Jiang X, Pennicooke B, Park PJ, Johnson MD", "evidence": [ { "database": "Reactome", "id": "R-HSA-5628897", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5628897" } ], "reference": [ { "type": "PubMed", "id": "20080666", "url": "https://glygen.org/publication/PubMed/20080666" } ] }, { "title": "Involvement of epigenetically silenced microRNA-181c in gastric carcinogenesis.", "journal": "Carcinogenesis", "date": "2010", "authors": "Hashimoto Y, Akiyama Y, Otsubo T, Shimada S, Yuasa Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-1912408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1912408" } ], "reference": [ { "type": "PubMed", "id": "20080834", "url": "https://glygen.org/publication/PubMed/20080834" } ] }, { "title": "Quantitative model for inferring dynamic regulation of the tumour suppressor gene p53.", "journal": "BMC bioinformatics", "date": "2010", "authors": "Wang J, Tian T", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "20085646", "url": "https://glygen.org/publication/PubMed/20085646" } ] }, { "title": "Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen.", "journal": "Nature", "date": "2010", "authors": "Bienvenu F, Jirawatnotai S, Elias JE, Meyer CA, Mizeracka K, Marson A, Frampton GM, Cole MF, Odom DT, Odajima J, Geng Y, Zagozdzon A, Jecrois M, Young RA, Liu XS, Cepko CL, Gygi SP, Sicinski P", "evidence": [ { "database": "Reactome", "id": "R-HSA-1912408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1912408" } ], "reference": [ { "type": "PubMed", "id": "20090754", "url": "https://glygen.org/publication/PubMed/20090754" } ] }, { "title": "Edaravone, a known free radical scavenger, enhances X-ray-induced apoptosis at low concentrations.", "journal": "Cancer letters", "date": "2010", "authors": "Sasano N, Enomoto A, Hosoi Y, Katsumura Y, Matsumoto Y, Morita A, Shiraishi K, Miyagawa K, Igaki H, Nakagawa K", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "20092938", "url": "https://glygen.org/publication/PubMed/20092938" } ] }, { "title": "TAF6delta orchestrates an apoptotic transcriptome profile and interacts functionally with p53.", "journal": "BMC Mol. Biol.", "date": "2010", "authors": "Tora L., Benecke A., Frontini M., Bell B., Kornete M., Targat B., Vigneault-Edwards J., Wilhelm E.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "20096117", "url": "https://glygen.org/publication/PubMed/20096117" } ] }, { "title": "USP10 regulates p53 localization and stability by deubiquitinating p53.", "journal": "Cell", "date": "2010", "authors": "Yuan J., Zhang L., Cheville J.C., Luo K., Lou Z.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "20096447", "url": "https://glygen.org/publication/PubMed/20096447" } ] }, { "title": "SMAR1 regulates free radical stress through modulation of AKR1a4 enzyme activity.", "journal": "The international journal of biochemistry & cell biology", "date": "2010", "authors": "Singh S, Sreenath K, Pavithra L, Roy S, Chattopadhyay S", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "20097305", "url": "https://glygen.org/publication/PubMed/20097305" } ] }, { "title": "G9a and Glp methylate lysine 373 in the tumor suppressor p53.", "journal": "J. Biol. Chem.", "date": "2010", "authors": "Huang J., Zhang X., Reinberg D., Chuikov S., Jenuwein T., Berger S.L., Dorsey J., Perez-Burgos L.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "Reactome", "id": "R-HSA-6804760", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804760" } ], "reference": [ { "type": "PubMed", "id": "20118233", "url": "https://glygen.org/publication/PubMed/20118233" } ] }, { "title": "Requirement of ATM for rapid p53 phosphorylation at Ser46 without Ser/Thr-Gln sequences.", "journal": "Molecular and cellular biology", "date": "2010", "authors": "Kodama M, Otsubo C, Hirota T, Yokota J, Enari M, Taya Y", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "20123963", "url": "https://glygen.org/publication/PubMed/20123963" } ] }, { "title": "G-protein-coupled receptor kinase 5 phosphorylates p53 and inhibits DNA damage-induced apoptosis.", "journal": "J. Biol. Chem.", "date": "2010", "authors": "Chen X., Fu J., Zhou Y., Zhu H., Ma L., Yuan M.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "20124405", "url": "https://glygen.org/publication/PubMed/20124405" } ] }, { "title": "Toward the rational design of p53-stabilizing drugs: probing the surface of the oncogenic Y220C mutant.", "journal": "Chem. Biol.", "date": "2010", "authors": "Rutherford T.J., Fersht A.R., Basse N., Joerger A.C., Kaar J.L., Settanni G.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "20142040", "url": "https://glygen.org/publication/PubMed/20142040" } ] }, { "title": "Prostaglandin (PG)D(2) and 15-deoxy-Delta(12,14)-PGJ(2), but not PGE(2), mediate shear-induced chondrocyte apoptosis via protein kinase A-dependent regulation of polo-like kinases.", "journal": "Cell death and differentiation", "date": "2010", "authors": "Zhu F, Wang P, Kontrogianni-Konstantopoulos A, Konstantopoulos K", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "20150912", "url": "https://glygen.org/publication/PubMed/20150912" } ] }, { "title": "Differences in the transactivation domains of p53 family members: a computational study.", "journal": "BMC genomics", "date": "2010", "authors": "Mavinahalli JN, Madhumalar A, Beuerman RW, Lane DP, Verma C", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "20158876", "url": "https://glygen.org/publication/PubMed/20158876" } ] }, { "title": "Nox1 is involved in p53 deacetylation and suppression of its transcriptional activity and apoptosis.", "journal": "Free radical biology & medicine", "date": "2010", "authors": "Puca R, Nardinocchi L, Starace G, Rechavi G, Sacchi A, Givol D, D'Orazi G", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "20171273", "url": "https://glygen.org/publication/PubMed/20171273" } ] }, { "title": "RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2010", "authors": "Chu J., Gu W., Li M., Liu S., Qin J., Wang Y., Fu X., Yang T., Yi P., Jung S.Y., O'Malley B.W., Mu J.J., Yucer N.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "20173098", "url": "https://glygen.org/publication/PubMed/20173098" } ] }, { "title": "p53 regulation of the IGF-1/AKT/mTOR pathways and the endosomal compartment.", "journal": "Cold Spring Harbor perspectives in biology", "date": "2010", "authors": "Feng Z", "evidence": [ { "database": "Reactome", "id": "R-HSA-5628897", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5628897" } ], "reference": [ { "type": "PubMed", "id": "20182617", "url": "https://glygen.org/publication/PubMed/20182617" } ] }, { "title": "Upregulation of FOXM1 induces genomic instability in human epidermal keratinocytes.", "journal": "Molecular cancer", "date": "2010", "authors": "Teh MT, Gemenetzidis E, Chaplin T, Young BD, Philpott MP", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "20187950", "url": "https://glygen.org/publication/PubMed/20187950" } ] }, { "title": "The forkhead transcription factor Foxl2 is sumoylated in both human and mouse: sumoylation affects its stability, localization, and activity.", "journal": "PloS one", "date": "2010", "authors": "Marongiu M, Deiana M, Meloni A, Marcia L, Puddu A, Cao A, Schlessinger D, Crisponi L", "evidence": [ { "database": "Reactome", "id": "R-HSA-3232118", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3232118" } ], "reference": [ { "type": "PubMed", "id": "20209145", "url": "https://glygen.org/publication/PubMed/20209145" } ] }, { "title": "HY253, a novel decahydrofluorene analog, from Aralia continentalis, induces cell cycle arrest at the G1 phase and cytochrome c-mediated apoptosis in human lung cancer A549 cells.", "journal": "Journal of ethnopharmacology", "date": "2010", "authors": "Oh HL, Lee DK, Lim H, Lee CH", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "20219657", "url": "https://glygen.org/publication/PubMed/20219657" } ] }, { "title": "Potentiation of etoposide-induced apoptosis in HeLa cells by co-treatment with KG-135, a quality-controlled standardized ginsenoside formulation.", "journal": "Cancer letters", "date": "2010", "authors": "Lee WH, Choi JS, Kim HY, Park JH, Park BD, Cho SJ, Lee SK, Surh YJ", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "20226587", "url": "https://glygen.org/publication/PubMed/20226587" } ] }, { "title": "Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A.", "journal": "Nature cell biology", "date": "2010", "authors": "Pereg Y, Liu BY, O'Rourke KM, Sagolla M, Dey A, Komuves L, French DM, Dixit VM", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "20228808", "url": "https://glygen.org/publication/PubMed/20228808" } ] }, { "title": "BRD7 is a candidate tumour suppressor gene required for p53 function.", "journal": "Nat. Cell Biol.", "date": "2010", "authors": "Agami R., Comel A., Del Sal G., Drost J., Elkon R., Holstege H., Jonkers J., Kerkhoven R., Mantovani F., Tocco F., Voorhoeve P.M.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "Reactome", "id": "R-HSA-6804758", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804758" } ], "reference": [ { "type": "PubMed", "id": "20228809", "url": "https://glygen.org/publication/PubMed/20228809" } ] }, { "title": "Requirement of the mTOR kinase for the regulation of Maf1 phosphorylation and control of RNA polymerase III-dependent transcription in cancer cells.", "journal": "The Journal of biological chemistry", "date": "2010", "authors": "Shor B, Wu J, Shakey Q, Toral-Barza L, Shi C, Follettie M, Yu K", "evidence": [ { "database": "Reactome", "id": "R-HSA-8943724", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8943724" } ], "reference": [ { "type": "PubMed", "id": 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"https://glygen.org/publication/PubMed/20234185" } ] }, { "title": "The inflammasomes.", "journal": "Cell", "date": "2010", "authors": "Schroder K, Tschopp J", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803207" } ], "reference": [ { "type": "PubMed", "id": "20303873", "url": "https://glygen.org/publication/PubMed/20303873" } ] }, { "title": "Chloroquine activates the p53 pathway and induces apoptosis in human glioma cells.", "journal": "Neuro-oncology", "date": "2010", "authors": "Kim EL, Wustenberg R, Rubsam A, Schmitz-Salue C, Warnecke G, Bucker EM, Pettkus N, Speidel D, Rohde V, Schulz-Schaeffer W, Deppert W, Giese A", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "20308316", "url": "https://glygen.org/publication/PubMed/20308316" } ] }, { "title": "mTOR complex-2 activates ENaC by phosphorylating SGK1.", "journal": "Journal of the American Society of Nephrology : JASN", "date": "2010", "authors": "Lu M, Wang J, Jones KT, Ives HE, Feldman ME, Yao LJ, Shokat KM, Ashrafi K, Pearce D", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804757", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804757" } ], "reference": [ { "type": "PubMed", "id": "20338997", "url": "https://glygen.org/publication/PubMed/20338997" } ] }, { "title": "Dose- and time-dependent effects of doxorubicin on cytotoxicity, cell cycle and apoptotic cell death in human colon cancer cells.", "journal": "Toxicology", "date": "2010", "authors": "Lupertz R, Watjen W, Kahl R, Chovolou Y", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "20346999", "url": "https://glygen.org/publication/PubMed/20346999" } ] }, { "title": "MicroRNA-34a suppresses invasion through 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Struct. Mol. Biol.", "date": "2010", "authors": "Honig B., Rohs R., Kitayner M., Rabinovich D., Rozenberg H., Shakked Z., Suad O.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "20364130", "url": "https://glygen.org/publication/PubMed/20364130" } ] }, { "title": "The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling.", "journal": "Cell research", "date": "2010", "authors": "Chen R, Zhang L, Zhong B, Tan B, Liu Y, Shu HB", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "20368735", "url": "https://glygen.org/publication/PubMed/20368735" } ] }, { "title": "Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function.", "journal": "Proceedings of the National Academy of Sciences of the United States of 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Guo QL", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "20413215", "url": "https://glygen.org/publication/PubMed/20413215" } ] }, { "title": "p53 Plays an important role in cell fate determination after exposure to microcystin-LR.", "journal": "Environmental health perspectives", "date": "2010", "authors": "Takumi S, Komatsu M, Furukawa T, Ikeda R, Sumizawa T, Akenaga H, Maeda Y, Aoyama K, Arizono K, Ando S, Takeuchi T", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "20421190", "url": "https://glygen.org/publication/PubMed/20421190" } ] }, { "title": "Novel germ line mutation p53-P177R in adult adrenocortical carcinoma producing neuron-specific enolase as a possible marker.", "journal": "Japanese journal of clinical oncology", "date": "2010", "authors": "Ide H, Terado Y, Tokiwa S, Nishio K, Saito K, Isotani S, Kamiyama Y, Muto S, Imamura T, Horie S", "evidence": [ { "database": "Entrez", "id": "7157", "url": "https://www.ncbi.nlm.nih.gov/gene/7157" } ], "reference": [ { "type": "PubMed", "id": "20421238", "url": "https://glygen.org/publication/PubMed/20421238" } ] }, { "title": "Cell death of prostate cancer cells by specific amino acid restriction depends on alterations of glucose metabolism.", "journal": "Journal of cellular physiology", "date": "2010", "authors": "Fu YM, Lin H, Liu X, Fang W, Meadows GG", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "20432447", "url": "https://glygen.org/publication/PubMed/20432447" } ] }, { "title": "NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways.", "journal": "Cell", "date": "2010", "authors": "Cui J, Zhu L, Xia X, Wang HY, Legras X, Hong J, Ji J, Shen P, Zheng S, Chen ZJ, Wang RF", "evidence": [ { "database": "Reactome", "id": "R-HSA-9758274", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9758274" } ], "reference": [ { "type": "PubMed", "id": "20434986", "url": "https://glygen.org/publication/PubMed/20434986" } ] }, { "title": "Phospholipase D stabilizes HDM2 through an mTORC2/SGK1 pathway.", "journal": "Biochemical and biophysical research communications", "date": "2010", "authors": "Lyo D, Xu L, Foster DA", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804757", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804757" } ], "reference": [ { "type": "PubMed", "id": "20438709", "url": "https://glygen.org/publication/PubMed/20438709" } ] }, { "title": "DeltaNp63alpha repression of the Notch1 gene supports the proliferative capacity of normal human keratinocytes and cervical cancer cells.", "journal": "Cancer research", "date": "2010", "authors": "Yugawa T, Narisawa-Saito M, Yoshimatsu Y, Haga K, Ohno S, Egawa N, Fujita M, Kiyono T", "evidence": [ { "database": "Reactome", "id": "R-HSA-1912408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1912408" } ], "reference": [ { "type": "PubMed", "id": "20442293", "url": "https://glygen.org/publication/PubMed/20442293" } ] }, { "title": "Differential control of Notch1 gene transcription by Klf4 and Sp3 transcription factors in normal versus cancer-derived keratinocytes.", "journal": "PloS one", "date": "2010", "authors": "Lambertini C, Pantano S, Dotto GP", "evidence": [ { "database": "Reactome", "id": "R-HSA-1912408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1912408" } ], "reference": [ { "type": "PubMed", "id": "20442780", "url": "https://glygen.org/publication/PubMed/20442780" } ] }, { "title": "P53 gene polymorphisms and breast cancer risk in Arab women.", "journal": "Medical oncology (Northwood, London, England)", "date": "2011", "authors": "Alawadi S, Ghabreau L, Alsaleh M, Abdulaziz Z, Rafeek M, Akil N, Alkhalaf M", "evidence": [ { "database": "Entrez", "id": "7157", "url": "https://www.ncbi.nlm.nih.gov/gene/7157" } ], "reference": [ { "type": "PubMed", "id": "20443084", "url": "https://glygen.org/publication/PubMed/20443084" } ] }, { "title": "TP53 Pro47Ser and Arg72Pro polymorphisms and colorectal cancer predisposition in an ethnic Kashmiri population.", "journal": "Genetics and molecular research : GMR", "date": "2010", "authors": "Sameer AS, Shah ZA, Syeed N, Banday MZ, Bashir SM, Bhat BA, Siddiqi MA", "evidence": [ { "database": "Entrez", "id": "7157", "url": "https://www.ncbi.nlm.nih.gov/gene/7157" } ], "reference": [ { "type": "PubMed", "id": "20449797", "url": "https://glygen.org/publication/PubMed/20449797" } ] }, { "title": "Survey of familial glioma and role of germline p16INK4A/p14ARF and p53 mutation.", "journal": "Familial cancer", "date": "2010", "authors": "Robertson LB, Armstrong GN, Olver BD, Lloyd AL, Shete S, Lau C, Claus EB, Barnholtz-Sloan J, Lai R, Il'yasova D, Schildkraut J, Bernstein JL, Olson SH, Jenkins RB, Yang P, Rynearson AL, Wrensch M, McCoy L, Wienkce JK, McCarthy B, Davis F, Vick NA, Johansen C, Bodtcher H, Sadetzki S, Bruchim RB, Yechezkel GH, Andersson U, Melin BS, Bondy ML, Houlston RS", "evidence": [ { "database": "Entrez", "id": "7157", "url": "https://www.ncbi.nlm.nih.gov/gene/7157" } ], "reference": [ { "type": "PubMed", "id": "20455025", "url": "https://glygen.org/publication/PubMed/20455025" } ] }, { "title": "Curcuminoids activate p38 MAP kinases and promote UVB-dependent signalling in keratinocytes.", "journal": "Experimental dermatology", "date": "2010", "authors": "Ayli EE, Dugas-Breit S, Li W, Marshall C, Zhao L, Meulener M, Griffin T, Gelfand JM, Seykora JT", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "20456495", "url": "https://glygen.org/publication/PubMed/20456495" } ] 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interaction partner of p53 controlling oncogene-induced senescence.", "journal": "Aging", "date": "2010", "authors": "Mallette FA, Calabrese V, Ilangumaran S, Ferbeyre G", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "20622265", "url": "https://glygen.org/publication/PubMed/20622265" } ] }, { "title": "Regulation of immune cell homeostasis by type I interferons.", "journal": "Cytokine & growth factor reviews", "date": "2010", "authors": "Mattei F, Schiavoni G, Tough DF", "evidence": [ { "database": "Reactome", "id": "R-HSA-983231", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983231" } ], "reference": [ { "type": "PubMed", "id": "20627800", "url": "https://glygen.org/publication/PubMed/20627800" } ] }, { "title": "Immunotherapeutic targets in estrogen deficiency-dependent Sjogren's syndrome-related manifestations.", "journal": "Immunotherapy", "date": "2010", "authors": "Arakaki R, Ishimaru N, Hayashi Y", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "20635899", "url": "https://glygen.org/publication/PubMed/20635899" } ] }, { "title": "Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence.", "journal": "Proc. Natl. Acad. Sci. 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Biol. Chem.", "date": "2010", "authors": "Roy S., Appella E., Shi X., Kutateladze T.G., Hayashi R., Gozani O., Lachmi-Weiner K., West L.E.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "Reactome", "id": "R-HSA-6804760", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804760" } ], "reference": [ { "type": "PubMed", "id": "20870725", "url": "https://glygen.org/publication/PubMed/20870725" } ] }, { "title": "Short-hairpin RNA-induced suppression of adenine nucleotide translocase-2 in breast cancer cells restores their susceptibility to TRAIL-induced apoptosis by activating JNK and modulating TRAIL receptor expression.", "journal": "Molecular cancer", "date": "2010", "authors": "Jang JY, Jeon YK, Choi Y, Kim CW", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "20875141", "url": "https://glygen.org/publication/PubMed/20875141" } ] }, { "title": "Measurement of the cellular deacetylase activity of SIRT1 on p53 via LanthaScreen(R) technology.", "journal": "Molecular bioSystems", "date": "2011", "authors": "Robers MB, Loh C, Carlson CB, Yang H, Frey EA, Hermanson SB, Bi K", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "20931131", "url": "https://glygen.org/publication/PubMed/20931131" } ] }, { "title": "NCPMF-60 induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells.", "journal": "Anti-cancer drugs", "date": "2011", "authors": "Dai QS, Liu W, Wang XB, Lu N, Gong DD, Kong LY, Guo QL", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "20948430", "url": "https://glygen.org/publication/PubMed/20948430" } ] }, { "title": "Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression.", "journal": "J. 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Chem.", "date": "2011", "authors": "Wu L., Zhao Y., Jain A., Ma C.A.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "Reactome", "id": "R-HSA-6804756", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804756" }, { "database": "iPTMnet", "id": "P04637-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637-1" } ], "reference": [ { "type": "PubMed", "id": "20959462", "url": "https://glygen.org/publication/PubMed/20959462" } ] }, { "title": "Genomic characterization of asymptomatic CT-detected lung cancers.", "journal": "Oncogene", "date": "2011", "authors": "Belloni E, Veronesi G, Micucci C, Javan S, Minardi SP, Venturini E, Maisonneuve P, Volorio S, Riboni M, Bellomi M, Scanagatta P, Taliento G, Pelosi G, Pece S, Spaggiari L, Pelicci PG", "evidence": [ { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ 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treatment: an in vitro study.", "journal": "International journal of otolaryngology", "date": "2010", "authors": "Low WK, Kong SW, Tan MG", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21151649", "url": "https://glygen.org/publication/PubMed/21151649" } ] }, { "title": "Dose-dependent mutual regulation between Wip1 and p53 following UVC irradiation.", "journal": "The international journal of biochemistry & cell biology", "date": "2011", "authors": "Xia Y, Yang Q, Gong X, Ye F, Liou YC", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21163364", "url": "https://glygen.org/publication/PubMed/21163364" } ] }, { "title": "Ubiquitin proteasomal pathway mediated degradation of p53 in melanoma.", "journal": "Archives of biochemistry and biophysics", "date": "2011", "authors": "Anwar A, Norris DA, Fujita M", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21167122", "url": "https://glygen.org/publication/PubMed/21167122" } ] }, { "title": "MYCN sensitizes human neuroblastoma to apoptosis by HIPK2 activation through a DNA damage response.", "journal": "Molecular cancer research : MCR", "date": "2011", "authors": "Petroni M, Veschi V, Prodosmo A, Rinaldo C, Massimi I, Carbonari M, Dominici C, McDowell HP, Rinaldi C, Screpanti I, Frati L, Bartolazzi A, Gulino A, Soddu S, Giannini G", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21173028", "url": "https://glygen.org/publication/PubMed/21173028" } ] }, { "title": "Mutant p53 R248Q but not R248W enhances in vitro invasiveness of human lung cancer NCI-H1299 cells.", "journal": "Biomedical research (Tokyo, Japan)", "date": "2010", "authors": "Yoshikawa K, Hamada J, Tada M, Kameyama T, Nakagawa K, Suzuki Y, Ikawa M, Hassan NM, Kitagawa Y, Moriuchi T", "evidence": [ { "database": "Entrez", "id": "7157", "url": "https://www.ncbi.nlm.nih.gov/gene/7157" } ], "reference": [ { "type": "PubMed", "id": "21187651", "url": "https://glygen.org/publication/PubMed/21187651" } ] }, { "title": "Association of the highly prevalent TP53 R337H mutation with pediatric choroid plexus carcinoma and osteosarcoma in southeast Brazil.", "journal": "Cancer", "date": "2011", "authors": "Seidinger AL, Mastellaro MJ, Paschoal Fortes F, Godoy Assumpcao J, Aparecida Cardinalli I, Aparecida Ganazza M, Correa Ribeiro R, Brandalise SR, Dos Santos Aguiar S, Yunes JA", "evidence": [ { "database": "Entrez", "id": "7157", "url": "https://www.ncbi.nlm.nih.gov/gene/7157" } ], "reference": [ { "type": "PubMed", "id": "21192060", "url": "https://glygen.org/publication/PubMed/21192060" } ] }, { "title": "Role of the SUMO-interacting motif in HIPK2 targeting to the PML nuclear bodies and regulation of p53.", "journal": "Experimental cell research", "date": "2011", "authors": "Sung KS, Lee YA, Kim ET, Lee SR, Ahn JH, Choi CY", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21192925", "url": "https://glygen.org/publication/PubMed/21192925" } ] }, { "title": "Functionalized graphene oxide as a nanocarrier in a multienzyme labeling amplification strategy for ultrasensitive electrochemical immunoassay of phosphorylated p53 (S392).", "journal": "Analytical chemistry", "date": "2011", "authors": "Du D, Wang L, Shao Y, Wang J, Engelhard MH, Lin Y", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": 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AM, Lane DP, Lain S", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21317459", "url": "https://glygen.org/publication/PubMed/21317459" } ] }, { "title": "A new role of NUAK1: directly phosphorylating p53 and regulating cell proliferation.", "journal": "Oncogene", "date": "2011", "authors": "Liu W., Sun Z.Y., Hou X., Liu C.Y., Liu J.E., Liu Z.Y.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "Reactome", "id": "R-HSA-6804756", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804756" }, { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21317932", "url": "https://glygen.org/publication/PubMed/21317932" } ] }, { "title": "VentX trans-activates p53 and p16ink4a to regulate 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sciences", "date": "2010", "authors": "Pirolli D, Carelli Alinovi C, Capoluongo E, Satta MA, Concolino P, Giardina B, De Rosa MC", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21339981", "url": "https://glygen.org/publication/PubMed/21339981" } ] }, { "title": "Allelic expression imbalance of TP53 mutated and polymorphic alleles in head and neck tumors.", "journal": "Omics : a journal of integrative biology", "date": "2011", "authors": "Ganci F, Conti S, Fontemaggi G, Manciocco V, Donzelli S, Covello R, Muti P, Strano S, Blandino G, Spriano G", "evidence": [ { "database": "Entrez", "id": "7157", "url": "https://www.ncbi.nlm.nih.gov/gene/7157" } ], "reference": [ { "type": "PubMed", "id": "21348641", "url": "https://glygen.org/publication/PubMed/21348641" } ] }, { "title": "Protein-protein interactions occur between p53 phosphoforms and ATM and 53BP1 at sites of exogenous DNA damage.", "journal": "Radiation research", "date": "2011", "authors": "Al Rashid ST, Harding SM, Law C, Coackley C, Bristow RG", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21361779", "url": "https://glygen.org/publication/PubMed/21361779" } ] }, { "title": "USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA polymerase beta.", "journal": "Molecular cell", "date": "2011", "authors": "Parsons JL, Dianova II, Khoronenkova SV, Edelmann MJ, Kessler BM, Dianov GL", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "21362556", "url": "https://glygen.org/publication/PubMed/21362556" } ] }, { "title": "Frataxin participates to the hypoxia-induced response in tumors.", "journal": "Cell death & disease", "date": "2011", "authors": "Guccini I, Serio D, Condo I, Rufini A, Tomassini B, Mangiola A, Maira G, Anile C, Fina D, Pallone F, Mongiardi MP, Levi A, Ventura N, Testi R, Malisan F", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21368894", "url": "https://glygen.org/publication/PubMed/21368894" } ] }, { "title": "Alternative TFAP2A isoforms have distinct activities in breast cancer.", "journal": "Breast cancer research : BCR", "date": "2011", "authors": "Berlato C, Chan KV, Price AM, Canosa M, Scibetta AG, Hurst HC", "evidence": [ { "database": "Reactome", "id": "R-HSA-3232118", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3232118" } ], "reference": [ { "type": "PubMed", "id": "21375726", "url": "https://glygen.org/publication/PubMed/21375726" } ] }, { "title": "MicroRNAs as participants in cytotoxicity of CdTe quantum dots in NIH/3T3 cells.", "journal": "Biomaterials", "date": "2011", "authors": "Li S, Wang Y, Wang H, Bai Y, Liang G, Wang Y, Huang N, Xiao Z", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21376392", "url": "https://glygen.org/publication/PubMed/21376392" } ] }, { "title": "EDD inhibits ATM-mediated phosphorylation of p53.", "journal": "The Journal of biological chemistry", "date": "2011", "authors": "Ling S, Lin WC", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21383020", "url": "https://glygen.org/publication/PubMed/21383020" } ] }, { "title": "Aberrant ribosome biogenesis activates c-Myc and ASK1 pathways resulting in p53-dependent G1 arrest.", "journal": "Oncogene", "date": "2011", "authors": "Kim HD, Kim TS, Kim J", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21383696", "url": "https://glygen.org/publication/PubMed/21383696" } ] }, { "title": "Downregulation of VRK1 by p53 in response to DNA damage is mediated by the autophagic pathway.", "journal": "PloS one", "date": "2011", "authors": "Valbuena A, Castro-Obregon S, Lazo PA", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21386980", "url": "https://glygen.org/publication/PubMed/21386980" } ] }, { "title": "Phosphorylation of SMC1 by ATR is required for desferrioxamine (DFO)-induced apoptosis.", "journal": "Cell death & disease", "date": "2011", "authors": "So EY, Ausman M, Saeki T, Ouchi T", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21390062", "url": "https://glygen.org/publication/PubMed/21390062" } ] }, { "title": "Role of p53 serine 46 in p53 target gene regulation.", "journal": "PloS one", "date": "2011", "authors": "Smeenk L, van Heeringen SJ, Koeppel M, Gilbert B, Janssen-Megens E, Stunnenberg HG, Lohrum M", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21394211", "url": "https://glygen.org/publication/PubMed/21394211" } ] }, { "title": "Endothelial Jarid2/Jumonji is required for normal cardiac development and proper Notch1 expression.", "journal": "The Journal of biological chemistry", "date": "2011", "authors": "Mysliwiec MR, Bresnick EH, Lee Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-1912408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1912408" } ], "reference": [ { "type": "PubMed", "id": "21402699", "url": "https://glygen.org/publication/PubMed/21402699" } ] }, { "title": "Mediterranean diet supplemented with coenzyme Q10 induces postprandial changes in p53 in response to oxidative DNA damage in elderly subjects.", "journal": "Age (Dordrecht, Netherlands)", "date": "2012", "authors": "Gutierrez-Mariscal FM, Perez-Martinez P, Delgado-Lista J, Yubero-Serrano EM, Camargo A, Delgado-Casado N, Cruz-Teno C, Santos-Gonzalez M, Rodriguez-Cantalejo F, Castano JP, Villalba-Montoro JM, Fuentes F, Perez-Jimenez F, Lopez-Miranda J", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21404051", "url": "https://glygen.org/publication/PubMed/21404051" } ] }, { "title": "Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1990", "authors": "Marshak D.R., Beach D., Prives C., Bischoff J.R., Friedman P.N.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "2141171", "url": "https://glygen.org/publication/PubMed/2141171" } ] }, { "title": "Specific inhibition of NF-Y subunits triggers different cell proliferation defects.", "journal": "Nucleic acids research", "date": "2011", "authors": "Benatti P, Dolfini D, Vigano A, Ravo M, Weisz A, Imbriano C", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21415014", "url": "https://glygen.org/publication/PubMed/21415014" } ] }, { "title": "Delayed caspase-8 activation and enhanced integrin beta1-activated FAK underpins anoikis in oesophageal carcinoma cells harbouring mt p53-R175H.", "journal": "Cell biology international", "date": "2011", "authors": "Fanucchi S, Veale RB", "evidence": [ { "database": "Entrez", "id": "7157", "url": "https://www.ncbi.nlm.nih.gov/gene/7157" } ], "reference": [ { "type": "PubMed", "id": "21426305", "url": "https://glygen.org/publication/PubMed/21426305" } ] }, { "title": "Withaferin a suppresses estrogen receptor-alpha expression in human breast cancer cells.", "journal": "Molecular carcinogenesis", "date": "2011", "authors": "Hahm ER, Lee J, Huang Y, Singh SV", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21432907", "url": "https://glygen.org/publication/PubMed/21432907" } ] }, { "title": "Increased incidence of choroid plexus carcinoma due to the germline TP53 R337H mutation in southern Brazil.", "journal": "PloS one", "date": "2011", "authors": "Custodio G, Taques GR, Figueiredo BC, Gugelmin ES, Oliveira Figueiredo MM, Watanabe F, Pontarolo R, Lalli E, Torres LF", "evidence": [ { "database": "Entrez", "id": "7157", "url": "https://www.ncbi.nlm.nih.gov/gene/7157" } ], "reference": [ { "type": "PubMed", "id": "21445348", "url": "https://glygen.org/publication/PubMed/21445348" } ] }, { "title": "PERP expression stabilizes active p53 via modulation of p53-MDM2 interaction in uveal melanoma cells.", "journal": "Cell death & disease", "date": "2011", "authors": "Davies L, Spiller D, White MR, Grierson I, Paraoan L", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21451571", "url": "https://glygen.org/publication/PubMed/21451571" } ] }, { "title": "Cancer susceptibility polymorphism of p53 at codon 72 affects phosphorylation and degradation of p53 protein.", "journal": "The Journal of biological chemistry", "date": "2011", "authors": "Ozeki C, Sawai Y, Shibata T, Kohno T, Okamoto K, Yokota J, Tashiro F, Tanuma S, Sakai R, Kawase T, Kitabayashi I, Taya Y, Ohki R", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21454683", "url": "https://glygen.org/publication/PubMed/21454683" } ] }, { "title": "Abl interconnects oncogenic Met and p53 core pathways in cancer cells.", "journal": "Cell death and differentiation", "date": "2011", "authors": "Furlan A, Stagni V, Hussain A, Richelme S, Conti F, Prodosmo A, Destro A, Roncalli M, Barila D, Maina F", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21455220", "url": "https://glygen.org/publication/PubMed/21455220" } ] }, { "title": "Characterization of human breast cancer cell lines for the studies on p53 in chemical carcinogenesis.", "journal": "Toxicology in vitro : an international journal published in association with BIBRA", "date": "2011", "authors": "Huovinen M, Loikkanen J, Myllynen P, Vahakangas KH", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21457773", "url": "https://glygen.org/publication/PubMed/21457773" } ] }, { "title": "Modifications of p53 and the DNA damage response in cells expressing mutant form of the protein huntingtin.", "journal": "Journal of molecular neuroscience : MN", "date": "2011", "authors": "Illuzzi JL, Vickers CA, Kmiec EB", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21465263", "url": "https://glygen.org/publication/PubMed/21465263" } ] }, { "title": "Over Expression of Nucleophosmin and Nucleolin Contributes to the Suboptimal Activation of a G2/M Checkpoint in Ataxia Telangiectasia Fibroblasts.", "journal": "Molecular and cellular pharmacology", "date": "2010", "authors": "Nalabothula N, Chakravarty D, Pierce A, Carrier F", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21499441", "url": "https://glygen.org/publication/PubMed/21499441" } ] }, { "title": "Mutational characterization of individual breast tumors: TP53 and PI3K pathway genes are frequently and distinctively mutated in different subtypes.", "journal": "Breast cancer research and treatment", "date": "2012", "authors": "Boyault S, Drouet Y, Navarro C, Bachelot T, Lasset C, Treilleux I, Tabone E, Puisieux A, Wang Q", "evidence": [ { "database": "dbSNP", "id": "rs587782329", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs587782329" } ], "reference": [ 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"http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21532991", "url": "https://glygen.org/publication/PubMed/21532991" } ] }, { "title": "In the absence of cellular poly (A) binding protein, the glycolytic enzyme GAPDH translocated to the cell nucleus and activated the GAPDH mediated apoptotic pathway by enhancing acetylation and serine 46 phosphorylation of p53.", "journal": "Biochemical and biophysical research communications", "date": "2011", "authors": "Thangima Zannat M, Bhattacharjee RB, Bag J", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21539808", "url": "https://glygen.org/publication/PubMed/21539808" } ] }, { "title": "Induction of apoptosis in colon cancer cells by a novel topoisomerase I inhibitor TopIn.", "journal": "Biochemical and biophysical research communications", "date": "2011", "authors": "Bae SK, Gwak J, Song IS, Park HS, Oh S", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21549095", "url": "https://glygen.org/publication/PubMed/21549095" } ] }, { "title": "Modulation of microRNA expression in human T-cell development: targeting of NOTCH3 by miR-150.", "journal": "Blood", "date": "2011", "authors": "Ghisi M, Corradin A, Basso K, Frasson C, Serafin V, Mukherjee S, Mussolin L, Ruggero K, Bonanno L, Guffanti A, De Bellis G, Gerosa G, Stellin G, D'Agostino DM, Basso G, Bronte V, Indraccolo S, Amadori A, Zanovello P", "evidence": [ { "database": "Reactome", "id": "R-HSA-1912408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1912408" } ], "reference": [ { "type": "PubMed", "id": "21551231", "url": "https://glygen.org/publication/PubMed/21551231" } ] }, { "title": "The p53 nuclear localisation signal is structurally linked to a p34cdc2 kinase motif.", "journal": "Oncogene", "date": "1990", "authors": "Addison C., Jenkins J.R., Sturzbecher H.-W.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "2156209", "url": "https://glygen.org/publication/PubMed/2156209" } ] }, { "title": "Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2011", "authors": "Chen M, Gutierrez GJ, Ronai ZA", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "21571647", "url": "https://glygen.org/publication/PubMed/21571647" } ] }, { "title": "IFI16 induction by glucose restriction in human fibroblasts contributes to autophagy through activation of the ATM/AMPK/p53 pathway.", "journal": "PloS one", "date": "2011", "authors": "Duan X, Ponomareva L, Veeranki S, Choubey D", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21573174", "url": "https://glygen.org/publication/PubMed/21573174" } ] }, { "title": "Two-phase dynamics of p53 in the DNA damage response.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2011", "authors": "Zhang XP, Liu F, Wang W", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21576488", "url": "https://glygen.org/publication/PubMed/21576488" } ] }, { "title": "Pharmacological activation of a novel p53-dependent S-phase checkpoint involving CHK-1.", "journal": "Cell death & disease", "date": "2011", "authors": "Ahmed A, Yang J, Maya-Mendoza A, Jackson DA, Ashcroft M", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21593792", "url": "https://glygen.org/publication/PubMed/21593792" } ] }, { "title": "Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry.", "journal": "Molecular cell", "date": "2011", "authors": "Huang X, Summers MK, Pham V, Lill JR, Liu J, Lee G, Kirkpatrick DS, Jackson PK, Fang G, Dixit VM", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "21596315", "url": "https://glygen.org/publication/PubMed/21596315" } ] }, { "title": "E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53.", "journal": "Cell Death Differ.", "date": "2011", "authors": "Lee J.Y., Jung J.H., Lee J.H., Lee S.J., Bae S., An S., Cha H.J., Jin Y.W., Lee K.H., Park I.C., Yoon Y., Suh K.S., Woo S.R.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "21597459", "url": "https://glygen.org/publication/PubMed/21597459" } ] }, { "title": "P53 mutations may be related to tumor invasiveness of human hepatocellular-carcinoma in china.", "journal": "Oncology reports", "date": "1995", "authors": "Qin L, Tang Z, Liu K, Ye S, Zhou G", "evidence": [ { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ { "type": "PubMed", "id": "21597878", "url": "https://glygen.org/publication/PubMed/21597878" } ] }, { "title": "Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway.", "journal": "Nature cell biology", "date": "2011", "authors": "Marcet B, Chevalier B, Luxardi G, Coraux C, Zaragosi LE, Cibois M, Robbe-Sermesant K, Jolly T, Cardinaud B, Moreilhon C, Giovannini-Chami L, Nawrocki-Raby B, Birembaut P, Waldmann R, Kodjabachian L, Barbry P", "evidence": [ { "database": "Reactome", "id": "R-HSA-1912408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1912408" } ], "reference": [ { "type": "PubMed", "id": "21602795", "url": "https://glygen.org/publication/PubMed/21602795" } ] }, { "title": "HIPK2 phosphorylates DeltaNp63alpha and promotes its degradation in response to DNA damage.", "journal": "Oncogene", "date": "2011", "authors": "Lazzari C, Prodosmo A, Siepi F, Rinaldo C, Galli F, Gentileschi M, Bartolazzi A, Costanzo A, Sacchi A, Guerrini L, Soddu S", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": 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"https://glygen.org/publication/PubMed/21625555" } ] }, { "title": "The effect of ATM and ERK1/2 inhibition on mitoxantrone-induced cell death of leukaemic cells.", "journal": "Folia biologica", "date": "2011", "authors": "Seifrtova M, Havelek R, Chmelarova M, Cmielova J, Muthna D, Stoklasova A, Zemankova S, Rezacova M", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21631964", "url": "https://glygen.org/publication/PubMed/21631964" } ] }, { "title": "The human DEK oncogene regulates DNA damage response signaling and repair.", "journal": "Nucleic acids research", "date": "2011", "authors": "Kavanaugh GM, Wise-Draper TM, Morreale RJ, Morrison MA, Gole B, Schwemberger S, Tichy ED, Lu L, Babcock GF, Wells JM, Drissi R, Bissler JJ, Stambrook PJ, Andreassen PR, Wiesmuller L, Wells SI", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": 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"evidence": [ { "database": "Reactome", "id": "R-HSA-8853884", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8853884" } ], "reference": [ { "type": "PubMed", "id": "21670496", "url": "https://glygen.org/publication/PubMed/21670496" } ] }, { "title": "DNA damage signaling in response to 5-fluorouracil in three colorectal cancer cell lines with different mismatch repair and TP53 status.", "journal": "International journal of oncology", "date": "2011", "authors": "Adamsen BL, Kravik KL, De Angelis PM", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21674128", "url": "https://glygen.org/publication/PubMed/21674128" } ] }, { "title": "The cell death response to the ROS inducer, cobalt chloride, in neuroblastoma cell lines according to p53 status.", "journal": "International journal of oncology", "date": "2011", "authors": "Stenger C, Naves T, Verdier M, 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HY, Zhu L, Matsueda S, Wang Q, Yang X, Hong J, Songyang Z, Chen ZJ, Wang RF", "evidence": [ { "database": "Reactome", "id": "R-HSA-9758274", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9758274" } ], "reference": [ { "type": "PubMed", "id": "21703539", "url": "https://glygen.org/publication/PubMed/21703539" } ] }, { "title": "Graphene-based immunosensor for electrochemical quantification of phosphorylated p53 (S15).", "journal": "Analytica chimica acta", "date": "2011", "authors": "Xie Y, Chen A, Du D, Lin Y", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21704756", "url": "https://glygen.org/publication/PubMed/21704756" } ] }, { "title": "MYCN sensitizes neuroblastoma to the MDM2-p53 antagonists Nutlin-3 and MI-63.", "journal": "Oncogene", "date": "2012", "authors": "Gamble LD, Kees UR, Tweddle DA, Lunec J", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21725357", "url": "https://glygen.org/publication/PubMed/21725357" } ] }, { "title": "STAT3 protein promotes T-cell survival and inhibits interleukin-2 production through up-regulation of Class O Forkhead transcription factors.", "journal": "The Journal of biological chemistry", "date": "2011", "authors": "Oh HM, Yu CR, Golestaneh N, Amadi-Obi A, Lee YS, Eseonu A, Mahdi RM, Egwuagu CE", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "21730069", "url": "https://glygen.org/publication/PubMed/21730069" } ] }, { "title": "Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2011", "authors": "Pant V, Xiong S, Iwakuma T, Quintas-Cardama A, Lozano G", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804757", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804757" } ], "reference": [ { "type": "PubMed", "id": "21730132", "url": "https://glygen.org/publication/PubMed/21730132" } ] }, { "title": "The p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivo.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2011", "authors": "Huang L, Yan Z, Liao X, Li Y, Yang J, Wang ZG, Zuo Y, Kawai H, Shadfan M, Ganapathy S, Yuan ZM", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804757", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804757" } ], "reference": [ { "type": "PubMed", "id": "21730163", "url": "https://glygen.org/publication/PubMed/21730163" } ] }, { "title": "Physical exercise regulates p53 activity targeting SCO2 and increases mitochondrial COX biogenesis in cardiac muscle with age.", "journal": "PloS one", "date": "2011", "authors": "Qi Z, He J, Su Y, He Q, Liu J, Yu L, Al-Attas O, Hussain T, Ding S, Ji L, Qian M", "evidence": [ { "database": "Reactome", "id": "R-HSA-5628897", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5628897" } ], "reference": [ { "type": "PubMed", "id": "21750704", "url": "https://glygen.org/publication/PubMed/21750704" } ] }, { "title": "The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53.", "journal": "Cell", "date": "1990", "authors": "Levine A.J., Huibregtse J.M., Scheffner M., Howley P.M., Werness B.A.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "2175676", "url": "https://glygen.org/publication/PubMed/2175676" } ] }, { "title": "High-level expression of wild-type p53 in melanoma cells is frequently associated with inactivity in p53 reporter gene assays.", "journal": "PloS one", "date": "2011", "authors": "Houben R, Hesbacher S, Schmid CP, Kauczok CS, Flohr U, Haferkamp S, Muller CS, Schrama D, Wischhusen J, Becker JC", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21760960", "url": "https://glygen.org/publication/PubMed/21760960" } ] }, { "title": "Induction and activation of the p53 pathway: a role for the protein kinase CK2?", "journal": "Molecular and cellular biochemistry", "date": "2011", "authors": "Meek DW, Cox M", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21769452", "url": "https://glygen.org/publication/PubMed/21769452" } ] }, { "title": "p53 inhibits autophagy by interacting with the human ortholog of yeast Atg17, RB1CC1/FIP200.", "journal": "Cell cycle (Georgetown, Tex.)", "date": "2011", "authors": "Morselli E, Shen S, Ruckenstuhl C, Bauer MA, Marino G, Galluzzi L, Criollo A, Michaud M, Maiuri MC, Chano T, Madeo F, Kroemer G", "evidence": [ { "database": "Entrez", "id": "7157", "url": "https://www.ncbi.nlm.nih.gov/gene/7157" } ], "reference": [ { "type": "PubMed", "id": "21775823", "url": "https://glygen.org/publication/PubMed/21775823" } ] }, { "title": "Suppression of zinc-induced p53 phosphorylation and p21 expression by wortmannin in A549 human pulmonary epithelial cells.", "journal": "Environmental toxicology and pharmacology", "date": "2008", "authors": "Nakagawa J, Matsuoka M", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21783897", "url": "https://glygen.org/publication/PubMed/21783897" } ] }, { "title": "Multiplexed electrochemical immunoassay of phosphorylated proteins based on enzyme-functionalized gold nanorod labels and electric field-driven acceleration.", "journal": "Analytical chemistry", "date": "2011", "authors": "Du D, Wang J, Lu D, Dohnalkova A, Lin Y", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21797208", "url": "https://glygen.org/publication/PubMed/21797208" } ] }, { "title": "Human CABIN1 is a functional member of the human HIRA/UBN1/ASF1a histone H3.3 chaperone complex.", "journal": "Molecular and cellular biology", "date": "2011", "authors": "Rai TS, Puri A, McBryan T, Hoffman J, Tang Y, Pchelintsev NA, van Tuyn J, Marmorstein R, Schultz DC, Adams PD", "evidence": [ { "database": "Reactome", "id": "R-HSA-2559584", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2559584" } ], "reference": [ { "type": "PubMed", "id": "21807893", "url": "https://glygen.org/publication/PubMed/21807893" } ] }, { "title": "Genotoxicity of 7H-dibenzo[c,g]carbazole and its tissue-specific derivatives in human hepatoma HepG2 cells is related to CYP1A1/1A2 expression.", "journal": "Environmental and molecular mutagenesis", "date": "2011", "authors": "Gabelova A, Valovicova Z, Mesarosova M, Trilecova L, Hruba E, Marvanova S, Krcmar P, Milcova A, Schmuczerova J, Vondracek J, Machala M, Topinka J", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21809388", "url": "https://glygen.org/publication/PubMed/21809388" } ] }, { "title": "Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma.", "journal": "Nature genetics", "date": "2011", "authors": "Li M, Zhao H, Zhang X, Wood LD, Anders RA, Choti MA, Pawlik TM, Daniel HD, Kannangai R, Offerhaus GJ, Velculescu VE, Wang L, Zhou S, Vogelstein B, Hruban RH, Papadopoulos N, Cai J, Torbenson MS, Kinzler KW", "evidence": [ { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ { "type": "PubMed", "id": "21822264", "url": "https://glygen.org/publication/PubMed/21822264" } ] }, { "title": "Curaxins: anticancer compounds that simultaneously suppress NF-kappaB and activate p53 by targeting FACT.", "journal": "Science translational medicine", "date": "2011", "authors": "Gasparian AV, Burkhart CA, Purmal AA, Brodsky L, Pal M, Saranadasa M, Bosykh DA, Commane M, Guryanova OA, Pal S, Safina A, Sviridov S, Koman IE, Veith J, Komar AA, Gudkov AV, Gurova KV", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21832239", "url": "https://glygen.org/publication/PubMed/21832239" } ] }, { "title": "Metabolic utilization of exogenous pyruvate by mutant p53 (R175H) human melanoma cells promotes survival under glucose depletion.", "journal": "Cancer biology & therapy", "date": "2011", "authors": "Chavez-Perez VA, Strasberg-Rieber M, Rieber M", "evidence": [ { "database": "Entrez", "id": "7157", "url": "https://www.ncbi.nlm.nih.gov/gene/7157" } ], "reference": [ { "type": "PubMed", "id": "21832879", "url": "https://glygen.org/publication/PubMed/21832879" } ] }, { "title": "The PARP inhibitor PJ34 causes a PARP1-independent, p21 dependent mitotic arrest.", "journal": "DNA repair", "date": "2011", "authors": "Madison DL, Stauffer D, Lundblad JR", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21840268", "url": "https://glygen.org/publication/PubMed/21840268" } ] }, { "title": "The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2.", "journal": "The Journal of biological chemistry", "date": "2011", "authors": "Mei Y, Hahn AA, Hu S, Yang X", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "21849505", "url": "https://glygen.org/publication/PubMed/21849505" } ] }, { "title": "ATR-p53 restricts homologous recombination in response to replicative stress but does not limit DNA interstrand crosslink repair in lung cancer cells.", "journal": "PloS one", "date": "2011", "authors": "Sirbu BM, Lachmayer SJ, Wulfing V, Marten LM, Clarkson KE, Lee LW, Gheorghiu L, Zou L, Powell SN, Dahm-Daphi J, Willers H", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21857991", "url": "https://glygen.org/publication/PubMed/21857991" } ] }, { "title": "Selenoprotein W depletion induces a p53- and p21-dependent delay in cell cycle progression in RWPE-1 prostate epithelial cells.", "journal": "Journal of cellular biochemistry", "date": "2012", "authors": "Hawkes WC, Printsev I, Alkan Z", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21866568", "url": "https://glygen.org/publication/PubMed/21866568" } ] }, { "title": "Delayed cell cycle progression from SEPW1 depletion is p53- and p21-dependent in MCF-7 breast cancer cells.", "journal": "Biochemical and biophysical research communications", "date": "2011", "authors": "Hawkes WC, Alkan Z", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21875573", "url": "https://glygen.org/publication/PubMed/21875573" } ] }, { "title": "Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway.", "journal": "The Journal of experimental medicine", "date": "2011", "authors": "Viatour P, Ehmer U, Saddic LA, Dorrell C, Andersen JB, Lin C, Zmoos AF, Mazur PK, Schaffer BE, Ostermeier A, Vogel H, Sylvester KG, Thorgeirsson SS, Grompe M, Sage J", "evidence": [ { "database": "Reactome", "id": "R-HSA-1912408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1912408" } ], "reference": [ { "type": "PubMed", "id": "21875955", "url": "https://glygen.org/publication/PubMed/21875955" } ] }, { "title": "Mitochondrial GTP-AMP phosphotransferase. 2. Kinetic and equilibrium dialysis studies.", "journal": "European journal of biochemistry", "date": "1979", "authors": "Tomasselli AG, Noda LH", "evidence": [ { "database": "Reactome", "id": "R-HSA-983231", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983231" } ], "reference": [ { "type": "PubMed", "id": "218813", "url": "https://glygen.org/publication/PubMed/218813" } ] }, { "title": "Insulin receptor tyrosine kinase substrate enhances low levels of MDM2-mediated p53 ubiquitination.", "journal": "PloS one", "date": "2011", "authors": "Wang KS, Chen G, Shen HL, Li TT, Chen F, Wang QW, Wang ZQ, Han ZG, Zhang X", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21887275", "url": "https://glygen.org/publication/PubMed/21887275" } ] }, { "title": "MDM2 promotes SUMO-2/3 modification of p53 to modulate transcriptional activity.", "journal": "Cell cycle (Georgetown, Tex.)", "date": "2011", "authors": "Stindt MH, Carter S, Vigneron AM, Ryan KM, Vousden KH", "evidence": [ { "database": "Reactome", "id": "R-HSA-3232118", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3232118" } ], "reference": [ { "type": "PubMed", "id": "21900752", "url": "https://glygen.org/publication/PubMed/21900752" } ] }, { "title": "ZnO nanoparticles induce apoptosis in human dermal fibroblasts via p53 and p38 pathways.", "journal": "Toxicology in vitro : an international journal published in association with BIBRA", "date": "2011", "authors": "Meyer K, Rajanahalli P, Ahamed M, Rowe JJ, Hong Y", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21903158", "url": "https://glygen.org/publication/PubMed/21903158" } ] }, { "title": "AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy.", "journal": "Oncogene", "date": "2012", "authors": "Astle MV, Hannan KM, Ng PY, Lee RS, George AJ, Hsu AK, Haupt Y, Hannan RD, Pearson RB", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21909130", "url": "https://glygen.org/publication/PubMed/21909130" } ] }, { "title": "Logical network of genotoxic stress-induced NF-kappaB signal transduction predicts putative target structures for therapeutic intervention strategies.", "journal": "Advances and applications in bioinformatics and chemistry : AABC", "date": "2009", "authors": "Poltz R, Franke R, Schweitzer K, Klamt S, Gilles ED, Naumann M", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21918620", "url": "https://glygen.org/publication/PubMed/21918620" } ] }, { "title": "Signal transducers and activators of transcription 3 (STAT3) directly regulates cytokine-induced fascin expression and is required for breast cancer cell migration.", "journal": "The Journal of biological chemistry", "date": "2011", "authors": "Snyder M, Huang XY, Zhang JJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "21937440", "url": "https://glygen.org/publication/PubMed/21937440" } ] }, { "title": "The activation of the p53 pathway by the AMP mimetic AICAR is reduced by inhibitors of the ATM or mTOR kinases.", "journal": "Mechanisms of ageing and development", "date": "2011", "authors": "Zajkowicz A, Rusin M", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "21945951", "url": "https://glygen.org/publication/PubMed/21945951" } ] }, { "title": "A germline variant in the TP53 polyadenylation signal confers cancer susceptibility.", "journal": "Nat. Genet.", "date": "2011", "authors": "Gudbjartsson D.F., Gudmundsson J., Jonsson T., Kiemeney L.A., Kong A., Mates D., Mayordomo J.I., Rafnar T., Rudnai P., Stacey S.N., Stefansson K., Sulem P., Thorleifsson G., Thorsteinsdottir U., Xiao Y., Rice T., Hansen T., Pedersen O., Gudjonsson S.A., Johannsdottir H., Kumar R., Magnusson O.T., Neal D.E., Hemminki K., Garcia A., Jenkins R.B., Lindblom A., Schalken J.A., O'Neill B.P., Barkardottir R.B., Jorgensen T., Steinthorsdottir V., Aben K.K., Agnarsson B.A., Benediktsdottir K.R., Catalona W.J., Einarsson G.V., Fuertes F., Helfand B.T., Jonsson E., Navarrete S., Sigurdsson A., Donovan J.L., Hamdy F.C., Vogel U., Jonasdottir A., Masson G., Helgadottir H.T., Jonasson J.G., Tryggvadottir L., Rivera F., Olafsson J.H., Ragnarsson R., Sigurgeirsson B., Thorisdottir K., Badea P., Badescu D., Banasik K., Codreanu O., Constantin A., Constantinescu V., Corredera C., Cremers R.G., Csiki I.E., De Juan A., Decker P.A., Dinu D.E., Fuentelsaz V., Garcia-Prats M.D., Grasa P., Gurzau E., Hansen H.M., Jinga M., Jinga V., Johannsson O.T., Keku T.O., Koppova K., Kosel M.L., Kristjansdottir S., Lachance D.H., Mates I.N., Moller P.H., Nagore E., Nexo B.A., Overvad K., Panadero A., Peters W.H., Planelles D., Requena C., Sanambrosio E., Sandler R.S., Sigurdsson F., Sigurdsson H., Soriano V., Stefansson T., Tjonneland A., Valdimarsson T., Wiencke J., Witte D.R., Wrensch M., van Oort I.M., van Rossum M.M., van Spronsen D.J.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "21946351", "url": "https://glygen.org/publication/PubMed/21946351" } ] }, { "title": "NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor.", "journal": "Cell Cycle", "date": "2011", "authors": "Mori T., Fukushima T., Takenoshita S., Ikeda D.D., Kochi H.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": 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"https://glygen.org/publication/PubMed/21960246" } ] }, { "title": "Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13.", "journal": "Cell", "date": "2011", "authors": "Liu J, Xia H, Kim M, Xu L, Li Y, Zhang L, Cai Y, Norberg HV, Zhang T, Furuya T, Jin M, Zhu Z, Wang H, Yu J, Li Y, Hao Y, Choi A, Ke H, Ma D, Yuan J", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "21962518", "url": "https://glygen.org/publication/PubMed/21962518" } ] }, { "title": "SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function.", "journal": "The Journal of biological chemistry", "date": "2011", "authors": "Cong L, Pakala SB, Ohshiro K, Li DQ, Kumar R", "evidence": [ { "database": "Reactome", "id": "R-HSA-3232118", "url": 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E, Gustincich S, Persichetti F, Del Sal G", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22011578", "url": "https://glygen.org/publication/PubMed/22011578" } ] }, { "title": "The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes.", "journal": "Genes & development", "date": "2011", "authors": "Blazek D, Kohoutek J, Bartholomeeusen K, Johansen E, Hulinkova P, Luo Z, Cimermancic P, Ule J, Peterlin BM", "evidence": [ { "database": "Reactome", "id": "R-HSA-6796648", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6796648" } ], "reference": [ { "type": "PubMed", "id": "22012619", "url": "https://glygen.org/publication/PubMed/22012619" } ] }, { "title": "Loss of the candidate tumor suppressor BTG3 triggers acute cellular senescence via the ERK-JMJD3-p16(INK4a) signaling axis.", "journal": "Oncogene", "date": "2012", "authors": "Lin TY, Cheng YC, Yang HC, Lin WC, Wang CC, Lai PL, Shieh SY", "evidence": [ { "database": "Reactome", "id": "R-HSA-2559580", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2559580" } ], "reference": [ { "type": "PubMed", "id": "22020331", "url": "https://glygen.org/publication/PubMed/22020331" } ] }, { "title": "Cellular stress induced alterations in microRNA let-7a and let-7b expression are dependent on p53.", "journal": "PloS one", "date": "2011", "authors": "Saleh AD, Savage JE, Cao L, Soule BP, Ly D, DeGraff W, Harris CC, Mitchell JB, Simone NL", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22022355", "url": "https://glygen.org/publication/PubMed/22022355" } ] }, { "title": "SUMOylation of the Forkhead transcription factor FOXL2 promotes its stabilization/activation through transient recruitment to PML bodies.", "journal": "PloS one", "date": "2011", "authors": "Georges A, Benayoun BA, Marongiu M, Dipietromaria A, L'Hote D, Todeschini AL, Auer J, Crisponi L, Veitia RA", "evidence": [ { "database": "Reactome", "id": "R-HSA-3232118", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3232118" } ], "reference": [ { "type": "PubMed", "id": "22022399", "url": "https://glygen.org/publication/PubMed/22022399" } ] }, { "title": "Ubiquitin-specific protease 4 (USP4) targets TRAF2 and TRAF6 for deubiquitination and inhibits TNFalpha-induced cancer cell migration.", "journal": "The Biochemical journal", "date": "2012", "authors": "Xiao N, Li H, Luo J, Wang R, Chen H, Chen J, Wang P", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "22029577", "url": "https://glygen.org/publication/PubMed/22029577" } ] }, { "title": "Dissection of cell context-dependent interactions between HBx and p53 family members in regulation of apoptosis: a role for HBV-induced HCC.", "journal": "Cell cycle (Georgetown, Tex.)", "date": "2011", "authors": "Knoll S, Furst K, Thomas S, Villanueva Baselga S, Stoll A, Schaefer S, Putzer BM", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22030623", "url": "https://glygen.org/publication/PubMed/22030623" } ] }, { "title": "Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer.", "journal": "Nature genetics", "date": "2011", "authors": "Wang K, Kan J, Yuen ST, Shi ST, Chu KM, Law S, Chan TL, Kan Z, Chan AS, Tsui WY, Lee SP, Ho SL, Chan AK, Cheng GH, Roberts PC, Rejto PA, Gibson NW, Pocalyko DJ, Mao M, Xu J, Leung SY", "evidence": [ { "database": "dbSNP", "id": "rs28934873", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934873" } ], "reference": [ { "type": 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"https://glygen.org/publication/PubMed/22052707" } ] }, { "title": "Regulation of p53 stability and function by the deubiquitinating enzyme USP42.", "journal": "The EMBO journal", "date": "2011", "authors": "Hock AK, Vigneron AM, Carter S, Ludwig RL, Vousden KH", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "22085928", "url": "https://glygen.org/publication/PubMed/22085928" } ] }, { "title": "Aurora-B mediated ATM serine 1403 phosphorylation is required for mitotic ATM activation and the spindle checkpoint.", "journal": "Molecular cell", "date": "2011", "authors": "Yang C, Tang X, Guo X, Niikura Y, Kitagawa K, Cui K, Wong ST, Fu L, Xu B", "evidence": [ { "database": "iPTMnet", "id": "P04637-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637-1" } ], "reference": [ { "type": "PubMed", "id": "22099307", "url": "https://glygen.org/publication/PubMed/22099307" } ] }, { "title": "Jarid2 (Jumonji, AT rich interactive domain 2) regulates NOTCH1 expression via histone modification in the developing heart.", "journal": "The Journal of biological chemistry", "date": "2012", "authors": "Mysliwiec MR, Carlson CD, Tietjen J, Hung H, Ansari AZ, Lee Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-1912408", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1912408" } ], "reference": [ { "type": "PubMed", "id": "22110129", "url": "https://glygen.org/publication/PubMed/22110129" } ] }, { "title": "Cutaneous HPV23 E6 prevents p53 phosphorylation through interaction with HIPK2.", "journal": "PloS one", "date": "2011", "authors": "Muschik D, Braspenning-Wesch I, Stockfleth E, Rosl F, Hofmann TG, Nindl I", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22110707", "url": "https://glygen.org/publication/PubMed/22110707" } ] }, { "title": "The HDAC inhibitor depsipeptide transactivates the p53/p21 pathway by inducing DNA damage.", "journal": "DNA repair", "date": "2012", "authors": "Wang H, Zhou W, Zheng Z, Zhang P, Tu B, He Q, Zhu WG", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22112863", "url": "https://glygen.org/publication/PubMed/22112863" } ] }, { "title": "Viral single-strand DNA induces p53-dependent apoptosis in human embryonic stem cells.", "journal": "PloS one", "date": "2011", "authors": "Hirsch ML, Fagan BM, Dumitru R, Bower JJ, Yadav S, Porteus MH, Pevny LH, Samulski RJ", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22114676", "url": "https://glygen.org/publication/PubMed/22114676" } ] }, 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gene SALL4 suppresses transcription through recruitment of DNA methyltransferases.", "journal": "The Journal of biological chemistry", "date": "2012", "authors": "Yang J, Corsello TR, Ma Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-8943724", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8943724" } ], "reference": [ { "type": "PubMed", "id": "22128185", "url": "https://glygen.org/publication/PubMed/22128185" } ] }, { "title": "Cytosolic DNA triggers mitochondrial apoptosis via DNA damage signaling proteins independently of AIM2 and RNA polymerase III.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2012", "authors": "Wenzel M, Wunderlich M, Besch R, Poeck H, Willms S, Schwantes A, Kremer M, Sutter G, Endres S, Schmidt A, Rothenfusser S", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22140256", "url": "https://glygen.org/publication/PubMed/22140256" } ] }, { "title": "The response of human ectomesenchymal dental pulp stem cells to cisplatin treatment.", "journal": "International endodontic journal", "date": "2012", "authors": "Seifrtova M, Havelek R, Cmielova J, Jiroutova A, Soukup T, Bruckova L, Mokry J, English D, Rezacova M", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22142405", "url": "https://glygen.org/publication/PubMed/22142405" } ] }, { "title": "Aurora A mediates cross-talk between N- and C-terminal post-translational modifications of p53.", "journal": "Cancer biology & therapy", "date": "2011", "authors": "Warnock LJ, Raines SA, Milner J", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22157150", "url": 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"reference": [ { "type": "PubMed", "id": "22190353", "url": "https://glygen.org/publication/PubMed/22190353" } ] }, { "title": "p53 and DNA-dependent protein kinase catalytic subunit independently function in regulating actin damage-induced tetraploid G1 arrest.", "journal": "Experimental & molecular medicine", "date": "2012", "authors": "Chae HD, Kim SY, Park SE, Kim J, Shin DY", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22198295", "url": "https://glygen.org/publication/PubMed/22198295" } ] }, { "title": "Roles of STAT3 and ZEB1 proteins in E-cadherin down-regulation and human colorectal cancer epithelial-mesenchymal transition.", "journal": "The Journal of biological chemistry", "date": "2012", "authors": "Xiong H, Hong J, Du W, Lin YW, Ren LL, Wang YC, Su WY, Wang JL, Cui Y, Wang ZH, Fang JY", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", 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Journal of biological chemistry", "date": "2012", "authors": "Michal AM, So CH, Beeharry N, Shankar H, Mashayekhi R, Yen TJ, Benovic JL", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22223642", "url": "https://glygen.org/publication/PubMed/22223642" } ] }, { "title": "Structural mechanism of the phosphorylation-dependent dimerization of the MDC1 forkhead-associated domain.", "journal": "Nucleic acids research", "date": "2012", "authors": "Liu J, Luo S, Zhao H, Liao J, Li J, Yang C, Xu B, Stern DF, Xu X, Ye K", "evidence": [ { "database": "Reactome", "id": "R-HSA-5693565", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5693565" } ], "reference": [ { "type": "PubMed", "id": "22234877", "url": "https://glygen.org/publication/PubMed/22234877" } ] }, { "title": "GW8510 increases insulin expression in pancreatic alpha cells through activation of p53 transcriptional activity.", "journal": "PloS one", "date": "2012", "authors": "Fomina-Yadlin D, Kubicek S, Vetere A, He KH, Schreiber SL, Wagner BK", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22242153", "url": "https://glygen.org/publication/PubMed/22242153" } ] }, { "title": "Human papillomavirus 18 E6 inhibits phosphorylation of p53 expressed in HeLa cells.", "journal": "Cell & bioscience", "date": "2012", "authors": "Ajay AK, Meena AS, Bhat MK", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22244155", "url": "https://glygen.org/publication/PubMed/22244155" } ] }, { "title": "High and low LET radiation differentially induce normal tissue damage signals.", "journal": "International journal of radiation oncology, biology, physics", "date": "2012", "authors": "Niemantsverdriet M, van Goethem MJ, Bron R, Hogewerf W, Brandenburg S, Langendijk JA, van Luijk P, Coppes RP", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22245200", "url": "https://glygen.org/publication/PubMed/22245200" } ] }, { "title": "Evidence providing new insights into TOB-promoted deadenylation and supporting a link between TOB's deadenylation-enhancing and antiproliferative activities.", "journal": "Molecular and cellular biology", "date": "2012", "authors": "Ezzeddine N, Chen CY, Shyu AB", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804115", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804115" } ], "reference": [ { "type": "PubMed", "id": "22252318", "url": "https://glygen.org/publication/PubMed/22252318" } ] }, { "title": "Epstein-Barr virus oncoprotein LMP1 mediates survivin upregulation by p53 contributing to G1/S cell cycle progression in nasopharyngeal carcinoma.", "journal": "International journal of molecular medicine", "date": "2012", "authors": "Guo L, Tang M, Yang L, Xiao L, Bode AM, Li L, Dong Z, Cao Y", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22266808", "url": "https://glygen.org/publication/PubMed/22266808" } ] }, { "title": "Angiogenin functionally interacts with p53 and regulates p53-mediated apoptosis and cell survival.", "journal": "Oncogene", "date": "2012", "authors": "Sadagopan S, Veettil MV, Chakraborty S, Sharma-Walia N, Paudel N, Bottero V, Chandran B", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22266868", "url": "https://glygen.org/publication/PubMed/22266868" } ] }, { "title": "p53 Ser15 phosphorylation disrupts the p53-RPA70 complex and induces RPA70-mediated DNA repair in hypoxia.", "journal": "The Biochemical journal", "date": "2012", "authors": "Madan E, Gogna R, Pati U", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22288499", "url": "https://glygen.org/publication/PubMed/22288499" } ] }, { "title": "The dietary phytochemical 3,3'-diindolylmethane induces G2/M arrest and apoptosis in oral squamous cell carcinoma by modulating Akt-NF-kappaB, MAPK, and p53 signaling.", "journal": "Chemico-biological interactions", "date": "2012", "authors": "Weng JR, Bai LY, Chiu CF, Wang YC, Tsai MH", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22290291", "url": "https://glygen.org/publication/PubMed/22290291" } ] }, { "title": "The Role of Wild-Type p53 in Cisplatin-Induced Chk2 Phosphorylation and the Inhibition of Platinum Resistance with a Chk2 Inhibitor.", "journal": "Chemotherapy research and practice", "date": "2011", "authors": "Liang X, Guo Y, Figg WD, Fojo AT, Mueller MD, Yu JJ", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22312557", "url": "https://glygen.org/publication/PubMed/22312557" } ] }, { "title": "PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes.", "journal": "Molecular cell", "date": "2012", "authors": "Gao Z, Zhang J, Bonasio R, Strino F, Sawai A, Parisi F, Kluger Y, Reinberg D", "evidence": [ { "database": "Reactome", "id": "R-HSA-2559580", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2559580" } ], "reference": [ { "type": "PubMed", "id": "22325352", "url": "https://glygen.org/publication/PubMed/22325352" } ] }, { 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of Akt interaction protein PHF20/TZP that transcriptionally regulates p53.", "journal": "The Journal of biological chemistry", "date": "2012", "authors": "Park S, Kim D, Dan HC, Chen H, Testa JR, Cheng JQ", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804759", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804759" } ], "reference": [ { "type": "PubMed", "id": "22334668", "url": "https://glygen.org/publication/PubMed/22334668" } ] }, { "title": "Regulation of p14ARF expression by miR-24: a potential mechanism compromising the p53 response during retinoblastoma development.", "journal": "BMC cancer", "date": "2012", "authors": "To KH, Pajovic S, Gallie BL, Theriault BL", "evidence": [ { "database": "Reactome", "id": "R-HSA-2559580", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2559580" } ], "reference": [ { "type": "PubMed", "id": "22336108", "url": "https://glygen.org/publication/PubMed/22336108" } ] }, { "title": "The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2012", "authors": "Adams CJ, Pike AC, Maniam S, Sharpe TD, Coutts AS, Knapp S, La Thangue NB, Bullock AN", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804760", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804760" } ], "reference": [ { "type": "PubMed", "id": "22362889", "url": "https://glygen.org/publication/PubMed/22362889" } ] }, { "title": "Sestrin2 modulates AMPK subunit expression and its response to ionizing radiation in breast cancer cells.", "journal": "PloS one", "date": "2012", "authors": "Sanli T, Linher-Melville K, Tsakiridis T, Singh G", "evidence": [ { "database": "Reactome", "id": "R-HSA-5628897", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5628897" } ], "reference": [ { "type": "PubMed", "id": "22363791", "url": "https://glygen.org/publication/PubMed/22363791" } ] }, 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degradation of p53.", "journal": "The Biochemical journal", "date": "2012", "authors": "Sun NK, Huang SL, Chien KY, Chao CC", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22397410", "url": "https://glygen.org/publication/PubMed/22397410" } ] }, { "title": "Activation of DNA damage response pathways as a consequence of anthracycline-DNA adduct formation.", "journal": "Biochemical pharmacology", "date": "2012", "authors": "Forrest RA, Swift LP, Rephaeli A, Nudelman A, Kimura K, Phillips DR, Cutts SM", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22414726", "url": "https://glygen.org/publication/PubMed/22414726" } ] }, { "title": "Enhanced cytotoxicity of PARP inhibition in mantle cell lymphoma harbouring mutations in both ATM and p53.", "journal": "EMBO molecular medicine", "date": "2012", "authors": "Williamson CT, Kubota E, Hamill JD, Klimowicz A, Ye R, Muzik H, Dean M, Tu L, Gilley D, Magliocco AM, McKay BC, Bebb DG, Lees-Miller SP", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22416035", "url": "https://glygen.org/publication/PubMed/22416035" } ] }, { "title": "Re-oxygenation causes hypoxic tumor regression through restoration of p53 wild-type conformation and post-translational modifications.", "journal": "Cell death & disease", "date": "2012", "authors": "Gogna R, Madan E, Kuppusamy P, Pati U", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22419115", "url": "https://glygen.org/publication/PubMed/22419115" } ] }, { "title": "Upregulation of miR-24 is associated 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"Ido Y, Duranton A, Lan F, Cacicedo JM, Chen TC, Breton L, Ruderman NB", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22514710", "url": "https://glygen.org/publication/PubMed/22514710" } ] }, { "title": "Nucleolar protein GLTSCR2 stabilizes p53 in response to ribosomal stresses.", "journal": "Cell Death Differ.", "date": "2012", "authors": "Lee S., Kim Y.J., Kim J.H., Kim J.Y., Park J.H., Chang Y.J., Kang H.Y., Seok K.O.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "22522597", "url": "https://glygen.org/publication/PubMed/22522597" } ] }, { "title": "The Concept of Divergent Targeting through the Activation and Inhibition of Receptors as a Novel Chemotherapeutic Strategy: Signaling Responses to Strong DNA-Reactive Combinatorial Mimicries.", "journal": "Journal of signal transduction", "date": "2012", "authors": "Watt HL, Rachid Z, Jean-Claude BJ", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22523681", "url": "https://glygen.org/publication/PubMed/22523681" } ] }, { "title": "Murine protein serine-threonine kinase 38 activates p53 function through Ser15 phosphorylation.", "journal": "The Journal of biological chemistry", "date": "2012", "authors": "Seong HA, Ha H", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22532570", "url": "https://glygen.org/publication/PubMed/22532570" } ] }, { "title": "iASPP inhibits p53-independent apoptosis by inhibiting transcriptional activity of p63/p73 on promoters of proapoptotic genes.", "journal": "Apoptosis : an international journal on programmed cell death", "date": "2012", "authors": "Cai Y, Qiu S, Gao X, Gu SZ, Liu ZJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804759", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804759" } ], "reference": [ { "type": "PubMed", "id": "22538442", "url": "https://glygen.org/publication/PubMed/22538442" } ] }, { "title": "Increased aldehyde reductase expression mediates acquired radioresistance of laryngeal cancer cells via modulating p53.", "journal": "Cancer biology & therapy", "date": "2012", "authors": "Kim JS, Chang JW, Park JK, Hwang SG", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22555805", "url": "https://glygen.org/publication/PubMed/22555805" } ] }, { "title": "Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma.", "journal": "Nature genetics", "date": "2012", "authors": "Guichard C, Amaddeo G, Imbeaud S, Ladeiro Y, Pelletier L, Maad IB, Calderaro J, Bioulac-Sage P, Letexier M, Degos F, Clement B, Balabaud C, Chevet E, Laurent A, Couchy G, Letouze E, Calvo F, Zucman-Rossi J", "evidence": [ { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ { "type": "PubMed", "id": "22561517", "url": "https://glygen.org/publication/PubMed/22561517" } ] }, { "title": "Acriflavine enhances radiosensitivity of colon cancer cells through endoplasmic reticulum stress-mediated apoptosis.", "journal": "The international journal of biochemistry & cell biology", "date": "2012", "authors": "Lim MJ, Ahn JY, Han Y, Yu CH, Kim MH, Lee SL, Lim DS, Song JY", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22564437", "url": 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"Molecular cancer research : MCR", "date": "2012", "authors": "Kadekaro AL, Chen J, Yang J, Chen S, Jameson J, Swope VB, Cheng T, Kadakia M, Abdel-Malek Z", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22622028", "url": "https://glygen.org/publication/PubMed/22622028" } ] }, { "title": "Clioquinol induces DNA double-strand breaks, activation of ATM, and subsequent activation of p53 signaling.", "journal": "Toxicology", "date": "2012", "authors": "Katsuyama M, Iwata K, Ibi M, Matsuno K, Matsumoto M, Yabe-Nishimura C", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22627294", "url": "https://glygen.org/publication/PubMed/22627294" } ] }, { "title": "Frequent mutation of the p53 gene in human esophageal cancer.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1990", "authors": "Harris C.C., Montesano R., Hollstein M.C., Metcalf R.A., Welsh J.A.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "2263646", "url": "https://glygen.org/publication/PubMed/2263646" } ] }, { "title": "Valproic acid decreases the reparation capacity of irradiated MOLT-4 cells.", "journal": "Molekuliarnaia biologiia", "date": "2012", "authors": "Muthna D, Vavrova J, Lukasova E, Tichy A, Knizek J, Kohlerova R, Mazankova N, Rezacova M", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22642109", "url": "https://glygen.org/publication/PubMed/22642109" } ] }, { "title": "p53 modulation as a therapeutic strategy in gastrointestinal stromal tumors.", "journal": "PloS one", "date": "2012", "authors": "Henze J, Muhlenberg T, Simon S, Grabellus F, Rubin B, Taeger G, Schuler M, Treckmann J, Debiec-Rychter M, Taguchi T, Fletcher JA, Bauer S", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22662219", "url": "https://glygen.org/publication/PubMed/22662219" } ] }, { "title": "Respiratory syncytial virus matrix protein induces lung epithelial cell cycle arrest through a p53 dependent pathway.", "journal": "PloS one", "date": "2012", "authors": "Bian T, Gibbs JD, Orvell C, Imani F", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22662266", "url": "https://glygen.org/publication/PubMed/22662266" } ] }, { "title": "Aflatoxin-induced TP53 R249S mutation in hepatocellular carcinoma in Thailand: association with tumors developing in the absence of liver cirrhosis.", "journal": "PloS one", "date": "2012", "authors": "Villar S, Ortiz-Cuaran S, Abedi-Ardekani B, Gouas D, Nogueira da Costa A, Plymoth A, Khuhaprema T, Kalalak A, Sangrajrang S, Friesen MD, Groopman JD, Hainaut P", "evidence": [ { "database": "Entrez", "id": "7157", "url": "https://www.ncbi.nlm.nih.gov/gene/7157" } ], "reference": [ { "type": "PubMed", "id": "22675488", "url": "https://glygen.org/publication/PubMed/22675488" } ] }, { "title": "The mitochondrial pathway and reactive oxygen species are critical contributors to interferon-alpha/beta-mediated apoptosis in Ubp43-deficient hematopoietic cells.", "journal": "Biochemical and biophysical research communications", "date": "2012", "authors": "Yim HY, Yang Y, Lim JS, Lee MS, Zhang DE, Kim KI", "evidence": [ { "database": "Reactome", "id": "R-HSA-2559580", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2559580" } ], "reference": [ { "type": "PubMed", "id": "22683641", "url": "https://glygen.org/publication/PubMed/22683641" } ] }, { "title": "Viral oncoprotein LMP1 disrupts p53-induced cell cycle arrest and apoptosis through modulating K63-linked ubiquitination of p53.", "journal": "Cell cycle (Georgetown, Tex.)", "date": "2012", "authors": "Li L, Li W, Xiao L, Xu J, Chen X, Tang M, Dong Z, Tao Q, Cao Y", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22684299", "url": "https://glygen.org/publication/PubMed/22684299" } ] }, { "title": "STAT1 gene expression is enhanced by nuclear EGFR and HER2 via cooperation with STAT3.", "journal": "Molecular carcinogenesis", "date": "2013", "authors": "Han W, Carpenter RL, Cao X, Lo HW", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "22693070", "url": "https://glygen.org/publication/PubMed/22693070" } ] }, { "title": "S-phase sensing of DNA-protein crosslinks triggers TopBP1-independent ATR activation and p53-mediated cell death by formaldehyde.", "journal": "Cell cycle (Georgetown, Tex.)", "date": "2012", "authors": "Wong VC, Cash HL, Morse JL, Lu S, Zhitkovich A", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22722496", "url": "https://glygen.org/publication/PubMed/22722496" } ] }, { "title": "Novel mutations target distinct subgroups of medulloblastoma.", "journal": "Nature", "date": "2012", "authors": "Robinson G, Parker M, Kranenburg TA, Lu C, Chen X, Ding L, Phoenix TN, Hedlund E, Wei L, Zhu X, Chalhoub N, Baker SJ, Huether R, Kriwacki R, Curley N, Thiruvenkatam R, Wang J, Wu G, Rusch M, Hong X, Becksfort J, Gupta P, Ma J, Easton J, Vadodaria B, Onar-Thomas A, Lin T, Li S, Pounds S, Paugh S, Zhao D, Kawauchi D, Roussel MF, Finkelstein D, Ellison DW, Lau CC, Bouffet E, Hassall T, Gururangan S, Cohn R, Fulton RS, Fulton LL, Dooling DJ, Ochoa K, Gajjar A, Mardis ER, Wilson RK, Downing JR, Zhang J, Gilbertson RJ", "evidence": [ { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ { "type": "PubMed", "id": "22722829", "url": "https://glygen.org/publication/PubMed/22722829" } ] }, { "title": "The mutational landscape of lethal castration-resistant prostate cancer.", "journal": "Nature", "date": "2012", "authors": "Grasso CS, Wu YM, Robinson DR, Cao X, Dhanasekaran SM, Khan AP, Quist MJ, Jing X, Lonigro RJ, Brenner JC, Asangani IA, Ateeq B, Chun SY, Siddiqui J, Sam L, Anstett M, Mehra R, Prensner JR, Palanisamy N, Ryslik GA, Vandin F, Raphael BJ, Kunju LP, Rhodes DR, Pienta KJ, Chinnaiyan AM, Tomlins SA", "evidence": [ { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ { "type": "PubMed", "id": "22722839", "url": "https://glygen.org/publication/PubMed/22722839" } ] }, { "title": "p53 opens the mitochondrial permeability transition pore to trigger necrosis.", "journal": "Cell", "date": "2012", "authors": "Marchenko N.D., Holzmann S., Ji K., Moll U.M., Tsirka S.E., Vaseva A.V.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "22726440", "url": "https://glygen.org/publication/PubMed/22726440" } ] }, { "title": "Delayed cell cycle progression in selenoprotein W-depleted cells is regulated by a mitogen-activated protein kinase kinase 4-p38/c-Jun NH2-terminal kinase-p53 pathway.", "journal": "The Journal of biological chemistry", "date": "2012", "authors": "Hawkes WC, Alkan Z", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22730327", "url": "https://glygen.org/publication/PubMed/22730327" } ] }, { "title": "Co-expressions of casein kinase 2 (CK2) subunits restore the down-regulation of tubulin levels and disruption of microtubule structures caused by PrP mutants.", "journal": "Journal of molecular neuroscience : MN", "date": "2013", "authors": "Wang ZY, Shi Q, Wang SB, Tian C, Xu Y, Guo Y, Chen C, Zhang J, Dong XP", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22752506", "url": "https://glygen.org/publication/PubMed/22752506" } ] }, { "title": "TP53 R249S mutation, genetic variations in HBX and risk of hepatocellular carcinoma in The Gambia.", "journal": "Carcinogenesis", "date": "2012", "authors": "Gouas DA, Villar S, Ortiz-Cuaran S, Legros P, Ferro G, Kirk GD, Lesi OA, Mendy M, Bah E, Friesen MD, Groopman J, Chemin I, Hainaut P", "evidence": [ { "database": "Entrez", "id": "7157", "url": "https://www.ncbi.nlm.nih.gov/gene/7157" } ], "reference": [ { "type": "PubMed", "id": "22759751", "url": "https://glygen.org/publication/PubMed/22759751" } ] }, { "title": "iASPPsv antagonizes apoptosis induced by chemotherapeutic agents in MCF-7 cells and mouse thymocytes.", "journal": "Biochemical and biophysical research communications", "date": "2012", "authors": "Wang L, Xing H, Tian Z, Peng L, Li Y, Tang K, Rao Q, Wang M, Wang J", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803204", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803204" } ], "reference": [ { "type": "PubMed", "id": "22766503", "url": "https://glygen.org/publication/PubMed/22766503" } ] }, { "title": "Study of p53 expression and post-transcriptional modifications after GSM-900 radiofrequency exposure of human amniotic cells.", "journal": "Bioelectromagnetics", "date": "2013", "authors": "Bourthoumieu S, Magnaudeix A, Terro F, Leveque P, Collin A, Yardin C", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22767080", "url": "https://glygen.org/publication/PubMed/22767080" } ] }, { "title": "Polyphenols sensitization potentiates susceptibility of MCF-7 and MDA MB-231 cells to Centchroman.", "journal": "PloS one", "date": "2012", "authors": "Singh N, Zaidi D, Shyam H, Sharma R, Balapure AK", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22768036", "url": "https://glygen.org/publication/PubMed/22768036" } ] }, { "title": "C1B domain peptide of protein kinase Cgamma significantly suppresses growth of human colon cancer cells in vitro and in an in vivo mouse xenograft model through induction of cell cycle arrest and apoptosis.", "journal": "Cancer biology & therapy", "date": "2012", "authors": "Kawabata A, Matsuzuka T, Doi C, Seiler G, Reischman J, Pickel L, Ayuzawa R, Nguyen TA, Tamura M", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22785210", "url": "https://glygen.org/publication/PubMed/22785210" } ] }, { "title": "DNA-PK, ATM and ATR collaboratively regulate p53-RPA interaction to facilitate homologous recombination DNA repair.", "journal": "Oncogene", "date": "2013", "authors": "Serrano MA, Li Z, Dangeti M, Musich PR, Patrick S, Roginskaya M, Cartwright B, Zou Y", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22797063", "url": "https://glygen.org/publication/PubMed/22797063" } ] }, { "title": "E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression.", "journal": "Genes & development", "date": "2012", "authors": "Carvajal LA, Hamard PJ, Tonnessen C, Manfredi JJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804116", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804116" } ], "reference": [ { "type": "PubMed", "id": "22802528", "url": "https://glygen.org/publication/PubMed/22802528" } ] }, { "title": "The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence.", "journal": "Genes & development", "date": "2012", "authors": "Aksoy O, Chicas A, Zeng T, Zhao Z, McCurrach M, Wang X, Lowe SW", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804116", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804116" } ], "reference": [ { "type": "PubMed", "id": "22802529", "url": "https://glygen.org/publication/PubMed/22802529" } ] }, { "title": "HPV 5 and 8 E6 abrogate ATR activity resulting in increased persistence of UVB induced DNA damage.", "journal": "PLoS pathogens", "date": "2012", "authors": "Wallace NA, Robinson K, Howie HL, Galloway DA", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22807682", "url": "https://glygen.org/publication/PubMed/22807682" } ] }, { "title": "Involvement of p53 in the cytotoxic activity of the NAMPT inhibitor FK866 in myeloid leukemic cells.", "journal": "International journal of cancer", "date": "2013", "authors": "Thakur BK, Dittrich T, Chandra P, Becker A, Kuehnau W, Klusmann JH, Reinhardt D, Welte K", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22815158", "url": "https://glygen.org/publication/PubMed/22815158" } ] }, { "title": "Simulating molecular mechanisms of the MDM2-mediated regulatory interactions: a conformational selection model of the MDM2 lid dynamics.", "journal": "PloS one", "date": "2012", "authors": "Verkhivker GM", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22815859", "url": "https://glygen.org/publication/PubMed/22815859" } ] }, { "title": "Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations.", "journal": "Nature", "date": "2012", "authors": "Pugh TJ, Weeraratne SD, Archer TC, Pomeranz Krummel DA, Auclair D, Bochicchio J, Carneiro MO, Carter SL, Cibulskis K, Erlich RL, Greulich H, Lawrence MS, Lennon NJ, McKenna A, Meldrim J, Ramos AH, Ross MG, Russ C, Shefler E, Sivachenko A, Sogoloff B, Stojanov P, Tamayo P, Mesirov JP, Amani V, Teider N, Sengupta S, Francois JP, Northcott PA, Taylor MD, Yu F, Crabtree GR, Kautzman AG, Gabriel SB, Getz G, Jager N, Jones DT, Lichter P, Pfister SM, Roberts TM, Meyerson M, Pomeroy SL, Cho YJ", "evidence": [ { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ { "type": "PubMed", "id": "22820256", "url": "https://glygen.org/publication/PubMed/22820256" } ] }, { "title": "Disruption of the p53-p21 pathway inhibits efficiency of the lytic-replication cycle of herpes simplex virus type 2 (HSV-2).", "journal": "Virus research", "date": "2012", "authors": "Zhou Q, Zhu M, Zhang H, Yi T, Klena JD, Peng Y", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22820403", "url": "https://glygen.org/publication/PubMed/22820403" } ] }, { "title": "Regulation of human lung alveolar multipotent cells by a novel p38alpha MAPK/miR-17-92 axis.", "journal": "The EMBO journal", "date": "2012", "authors": "Oeztuerk-Winder F, Guinot A, Ochalek A, Ventura JJ", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22828869", "url": "https://glygen.org/publication/PubMed/22828869" } ] }, { "title": "Noscapine induced apoptosis via downregulation of survivin in human neuroblastoma cells having wild type or null p53.", "journal": "PloS one", "date": "2012", "authors": "Li S, He J, Li S, Cao G, Tang S, Tong Q, Joshi HC", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22848370", "url": "https://glygen.org/publication/PubMed/22848370" } ] }, { "title": "Interleukin-10-induced neutrophil gelatinase-associated lipocalin production in macrophages with consequences for tumor growth.", "journal": "Molecular and cellular biology", "date": "2012", "authors": "Jung M, Weigert A, Tausendschon M, Mora J, Oren B, Sola A, Hotter G, Muta T, Brune B", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "22851691", "url": "https://glygen.org/publication/PubMed/22851691" } ] }, { "title": "PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling.", "journal": "Molecular cell", "date": "2012", "authors": "Ando K, Kernan JL, Liu PH, Sanda T, Logette E, Tschopp J, Look AT, Wang J, Bouchier-Hayes L, Sidi S", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803207" } ], "reference": [ { "type": "PubMed", "id": "22854598", "url": "https://glygen.org/publication/PubMed/22854598" } ] }, { "title": "Endoplasmic reticulum stress stimulates p53 expression through NF-kappaB activation.", "journal": "PloS one", "date": "2012", "authors": "Lin WC, Chuang YC, Chang YS, Lai MD, Teng YN, Su IJ, Wang CC, Lee KH, Hung JH", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22859938", "url": "https://glygen.org/publication/PubMed/22859938" } ] }, { "title": "PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53.", "journal": "Nat. Struct. Mol. Biol.", "date": "2012", "authors": "Lee J., Kaneko S., Bedford M.T., Cheng J.Q., Kim D., Park S., Yuan Z., Thompson J.R., Yan F., Mer G., Botuyan M.V., Cui G., Badeaux A.I.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "Reactome", "id": "R-HSA-6804759", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804759" } ], "reference": [ { "type": "PubMed", "id": "22864287", "url": "https://glygen.org/publication/PubMed/22864287" } ] }, { "title": "Mutual regulation between SIAH2 and DYRK2 controls hypoxic and genotoxic signaling pathways.", "journal": "Journal of molecular cell biology", "date": "2012", "authors": "Perez M, Garcia-Limones C, Zapico I, Marina A, Schmitz ML, Munoz E, Calzado MA", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22878263", "url": "https://glygen.org/publication/PubMed/22878263" } ] }, { "title": "Interferon regulatory factor 4 binding protein is a novel p53 target gene and suppresses cisplatin-induced apoptosis of breast cancer cells.", "journal": "Molecular cancer", "date": "2012", "authors": "Yang M, Yuan F, Li P, Chen Z, Chen A, Li S, Hu C", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22888789", "url": "https://glygen.org/publication/PubMed/22888789" } ] }, { "title": "NDUFA4 is a subunit of complex IV of the mammalian electron transport chain.", "journal": "Cell metabolism", "date": "2012", "authors": "Balsa E, Marco R, Perales-Clemente E, Szklarczyk R, Calvo E, Landazuri MO, Enriquez JA", "evidence": [ { "database": "Reactome", "id": "R-HSA-5628897", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5628897" } ], "reference": [ { "type": "PubMed", "id": "22902835", "url": "https://glygen.org/publication/PubMed/22902835" } ] }, { "title": "Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2012", "authors": "Singh N, Basnet H, Wiltshire TD, Mohammad DH, Thompson JR, Heroux A, Botuyan MV, Yaffe MB, Couch FJ, Rosenfeld MG, Mer G", "evidence": [ { "database": "Reactome", "id": "R-HSA-5693565", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5693565" } ], "reference": [ { "type": "PubMed", "id": "22908299", "url": "https://glygen.org/publication/PubMed/22908299" } ] }, { "title": "Mitochondrial DNA maintenance is regulated in human hepatoma cells by glycogen synthase kinase 3beta and p53 in response to tumor necrosis factor alpha.", "journal": "PloS one", "date": "2012", "authors": "Vadrot N, Ghanem S, Braut F, Gavrilescu L, Pilard N, Mansouri A, Moreau R, Reyl-Desmars F", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22911714", "url": "https://glygen.org/publication/PubMed/22911714" } ] }, { "title": "PDCD5 interacts with p53 and functions as a positive regulator in the p53 pathway.", "journal": "Apoptosis : an international journal on programmed cell death", "date": "2012", "authors": "Xu L, Hu J, Zhao Y, Hu J, Xiao J, Wang Y, Ma D, Chen Y", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22914926", "url": "https://glygen.org/publication/PubMed/22914926" } ] }, { "title": "The prolyl-isomerase Pin1 activates the mitochondrial death program of p53.", "journal": "Cell death and differentiation", "date": "2013", "authors": "Sorrentino G, Mioni M, Giorgi C, Ruggeri N, Pinton P, Moll U, Mantovani F, Del Sal G", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22935610", "url": "https://glygen.org/publication/PubMed/22935610" } ] }, { "title": "Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer.", "journal": "Nature genetics", "date": "2012", "authors": "Rudin CM, Durinck S, Stawiski EW, Poirier JT, Modrusan Z, Shames DS, Bergbower EA, Guan Y, Shin J, Guillory J, Rivers CS, Foo CK, Bhatt D, Stinson J, Gnad F, Haverty PM, Gentleman R, Chaudhuri S, Janakiraman V, Jaiswal BS, Parikh C, Yuan W, Zhang Z, Koeppen H, Wu TD, Stern HM, Yauch RL, Huffman KE, Paskulin DD, Illei PB, Varella-Garcia M, Gazdar AF, de Sauvage FJ, Bourgon R, Minna JD, Brock MV, Seshagiri S", "evidence": [ { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ { "type": "PubMed", "id": "22941189", "url": "https://glygen.org/publication/PubMed/22941189" } ] }, { "title": "ZNF385B is characteristically expressed in germinal center B cells and involved in B-cell apoptosis.", "journal": "Eur. J. Immunol.", "date": "2012", "authors": "Iijima K., Kobayashi K., Miyagawa Y., Yamada H., Akimoto S., Fujimoto J., Kiyokawa N., Okita H., Fujiwara S., Nakazawa A., Imadome K., Miharu M.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "22945289", "url": "https://glygen.org/publication/PubMed/22945289" } ] }, { "title": "The effect of growth architecture on the induction and decay of bleomycin and X-ray-induced bystander response and genomic instability in lung adenocarcinoma cells and blood lymphocytes.", "journal": "International journal of radiation biology", "date": "2013", "authors": "Chinnadurai M, Paul SF, Venkatachalam P", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22947118", "url": "https://glygen.org/publication/PubMed/22947118" } ] }, { "title": "Akt phosphorylation in human chondrocytes is regulated by p53R2 in response to mechanical stress.", "journal": "Osteoarthritis and cartilage", "date": "2012", "authors": "Kawakita K, Nishiyama T, Fujishiro T, Hayashi S, Kanzaki N, Hashimoto S, Takebe K, Iwasa K, Sakata S, Nishida K, Kuroda R, Kurosaka M", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22954457", "url": "https://glygen.org/publication/PubMed/22954457" } ] }, { "title": "Ribavirin enhances the action of interferon-alpha against hepatitis C virus by promoting the p53 activity through the ERK1/2 pathway.", "journal": "PloS one", "date": "2012", "authors": "Liu WL, Yang HC, Su WC, Wang CC, Chen HL, Wang HY, Huang WH, Chen DS, Lai MY", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22962590", "url": "https://glygen.org/publication/PubMed/22962590" } ] }, { "title": "A `twist box` code of p53 inactivation: twist box: p53 interaction promotes p53 degradation.", "journal": "Cancer cell", "date": "2012", "authors": "Piccinin S, Tonin E, Sessa S, Demontis S, Rossi S, Pecciarini L, Zanatta L, Pivetta F, Grizzo A, Sonego M, Rosano C, Dei Tos AP, Doglioni C, Maestro R", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22975381", "url": "https://glygen.org/publication/PubMed/22975381" } ] }, { "title": "PKB-mediated PHF20 phosphorylation on Ser291 is required for p53 function in DNA damage.", "journal": "Cellular signalling", "date": "2013", "authors": "Li Y, Park J, Piao L, Kong G, Kim Y, Park KA, Zhang T, Hong J, Hur GM, Seok JH, Choi SW, Yoo BC, Hemmings BA, Brazil DP, Kim SH, Park J", "evidence": [ { "database": "Reactome", "id": 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"http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22983795", "url": "https://glygen.org/publication/PubMed/22983795" } ] }, { "title": "Interaction of cyclin-dependent kinase 12/CrkRS with cyclin K1 is required for the phosphorylation of the C-terminal domain of RNA polymerase II.", "journal": "Molecular and cellular biology", "date": "2012", "authors": "Cheng SW, Kuzyk MA, Moradian A, Ichu TA, Chang VC, Tien JF, Vollett SE, Griffith M, Marra MA, Morin GB", "evidence": [ { "database": "Reactome", "id": "R-HSA-6796648", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6796648" } ], "reference": [ { "type": "PubMed", "id": "22988298", "url": "https://glygen.org/publication/PubMed/22988298" } ] }, { "title": "Functional p53 determines docetaxel sensitivity in prostate cancer cells.", "journal": "The Prostate", "date": "2013", "authors": "Liu C, Zhu Y, Lou W, Nadiminty N, Chen X, Zhou Q, Shi XB, deVere White RW, Gao AC", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "22996738", "url": "https://glygen.org/publication/PubMed/22996738" } ] }, { "title": "R280T mutation of p53 gene promotes proliferation of human glioma cells through GSK-3beta/PTEN pathway.", "journal": "Neuroscience letters", "date": "2012", "authors": "Lin C, Liang Y, Zhu H, Zhang J, Zhong X", "evidence": [ { "database": "Entrez", "id": "7157", "url": "https://www.ncbi.nlm.nih.gov/gene/7157" } ], "reference": [ { "type": "PubMed", "id": "22999923", "url": "https://glygen.org/publication/PubMed/22999923" } ] }, { "title": "HIPK2 kinase activity depends on cis-autophosphorylation of its activation loop.", "journal": "Journal of molecular cell biology", "date": "2013", "authors": "Saul VV, de la Vega L, Milanovic M, Kruger M, Braun T, Fritz-Wolf K, Becker K, Schmitz ML", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804756", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804756" } ], "reference": [ { "type": "PubMed", "id": "23000554", "url": "https://glygen.org/publication/PubMed/23000554" } ] }, { "title": "DNA damage response in peritumoral regions of oesophageal cancer microenvironment.", "journal": "Carcinogenesis", "date": "2013", "authors": "He H, Tian D, Guo J, Liu M, Chen Z, Hamdy FC, Helleday T, Su M, Ying S", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "23027622", "url": "https://glygen.org/publication/PubMed/23027622" } ] }, { "title": "Anti-cancer activity of a novel small molecule compound that simultaneously activates p53 and inhibits NF-kappaB signaling.", "journal": "PloS one", "date": "2012", "authors": "Hwang SG, Park J, Park JY, Park CH, Lee KH, Cho JW, Hwang JI, Seong JY", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "23028510", "url": "https://glygen.org/publication/PubMed/23028510" } ] }, { "title": "NVX-412, a new oncology drug candidate, induces S-phase arrest and DNA damage in cancer cells in a p53-independent manner.", "journal": "PloS one", "date": "2012", "authors": "Hebar A, Rutgen BC, Selzer E", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "23028738", "url": "https://glygen.org/publication/PubMed/23028738" } ] }, { "title": "p53-Pathway activity and apoptosis in hydrogen sulfide-exposed stem cells separated from human gingival epithelium.", "journal": "Journal of periodontal research", "date": "2013", "authors": "Calenic B, Yaegaki K, Ishkitiev N, Kumazawa Y, Imai T, Tanaka T", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "23030661", "url": "https://glygen.org/publication/PubMed/23030661" } ] }, { "title": "Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events.", "journal": "Genome research", "date": "2012", "authors": "Liu J, Lee W, Jiang Z, Chen Z, Jhunjhunwala S, Haverty PM, Gnad F, Guan Y, Gilbert HN, Stinson J, Klijn C, Guillory J, Bhatt D, Vartanian S, Walter K, Chan J, Holcomb T, Dijkgraaf P, Johnson S, Koeman J, Minna JD, Gazdar AF, Stern HM, Hoeflich KP, Wu TD, Settleman J, de Sauvage FJ, Gentleman RC, Neve RM, Stokoe D, Modrusan Z, Seshagiri S, Shames DS, Zhang Z", "evidence": [ { "database": "dbSNP", "id": "rs1131691034", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1131691034" } ], "reference": [ { "type": "PubMed", "id": "23033341", "url": "https://glygen.org/publication/PubMed/23033341" } ] }, { "title": "MicroRNA-10b pleiotropically regulates invasion, angiogenicity and apoptosis of tumor cells resembling mesenchymal subtype of glioblastoma multiforme.", "journal": "Cell death & disease", "date": "2012", "authors": "Lin J, Teo S, Lam DH, Jeyaseelan K, Wang S", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "23034333", "url": "https://glygen.org/publication/PubMed/23034333" } ] }, { "title": "Persistent amplification of DNA damage signal involved in replicative senescence of normal human diploid fibroblasts.", "journal": "Oxidative medicine and cellular longevity", "date": "2012", "authors": "Suzuki M, Suzuki K, Kodama S, Yamashita S, Watanabe M", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "23050037", "url": "https://glygen.org/publication/PubMed/23050037" } ] }, { "title": "Bcl-2 family member Bcl-G is not a proapoptotic protein.", "journal": "Cell death & disease", "date": "2012", "authors": "Giam M, Okamoto T, Mintern JD, Strasser A, Bouillet P", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803205", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803205" } ], "reference": [ { "type": "PubMed", "id": "23059823", "url": "https://glygen.org/publication/PubMed/23059823" } ] }, { "title": "E2F8 is essential for polyploidization in mammalian cells.", "journal": "Nature cell biology", "date": "2012", "authors": "Pandit SK, Westendorp B, Nantasanti S, van Liere E, Tooten PC, Cornelissen PW, Toussaint MJ, Lamers WH, de Bruin A", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804116", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804116" } ], "reference": [ { "type": "PubMed", "id": "23064264", "url": "https://glygen.org/publication/PubMed/23064264" } ] }, { "title": "STAT1 activation by venous malformations mutant Tie2-R849W antagonizes VEGF-A-mediated angiogenic response partly via reduced bFGF production.", "journal": "Angiogenesis", "date": "2013", "authors": "Huang YH, Wu MP, Pan SC, Su WC, Chen YW, Wu LW", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "23086340", "url": "https://glygen.org/publication/PubMed/23086340" } ] }, { "title": "TIS21(/BTG2/PC3) accelerates the repair of DNA double strand breaks by enhancing Mre11 methylation and blocking damage signal transfer to the Chk2(T68)-p53(S20) pathway.", "journal": "DNA repair", "date": "2012", "authors": "Choi KS, Kim JY, Lim SK, Choi YW, Kim YH, Kang SY, Park TJ, Lim IK", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "23089312", "url": "https://glygen.org/publication/PubMed/23089312" } ] }, { "title": "Centrosome aberrations associated with cellular senescence and p53 localization at supernumerary centrosomes.", "journal": "Oxidative medicine and cellular longevity", "date": "2012", "authors": "Ohshima S", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "23091651", "url": "https://glygen.org/publication/PubMed/23091651" } ] }, { "title": "Whole-exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma.", "journal": "Oncotarget", "date": "2012", "authors": "Kannan K, Inagaki A, Silber J, Gorovets D, Zhang J, Kastenhuber ER, Heguy A, Petrini JH, Chan TA, Huse JT", "evidence": [ { "database": "dbSNP", "id": "rs1597349147", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1597349147" } ], "reference": [ { "type": "PubMed", "id": "23104868", "url": "https://glygen.org/publication/PubMed/23104868" } ] }, { "title": "5-Fluorouracil signaling through a calcium-calmodulin-dependent pathway is required for p53 activation and apoptosis in colon carcinoma cells.", "journal": "Oncogene", "date": "2013", "authors": "Can G, Akpinar B, Baran Y, Zhivotovsky B, Olsson M", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "23108402", "url": "https://glygen.org/publication/PubMed/23108402" } ] }, { "title": "Molecular basis for modulation of the p53 target selectivity by KLF4.", "journal": "PloS one", "date": "2012", "authors": "Brandt T, Townsley FM, Teufel DP, Freund SM, Veprintsev DB", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "23118962", "url": "https://glygen.org/publication/PubMed/23118962" } ] }, { "title": "IL-4 and IL-13 employ discrete signaling pathways for target gene expression in alternatively activated monocytes/macrophages.", "journal": "Free radical biology & medicine", "date": "2013", "authors": "Bhattacharjee A, Shukla M, Yakubenko VP, Mulya A, Kundu S, Cathcart MK", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "23124025", "url": "https://glygen.org/publication/PubMed/23124025" } ] }, { "title": "HY251, a novel decahydrocyclopenta[a]indene analog, induces apoptosis via tBid-mediated intrinsic pathway in human ovarian cancer PA-1 cells.", "journal": "Journal of microbiology and biotechnology", "date": "2012", "authors": "Suh H, Choi KW, Kim MS, Kim JH, Noh SY, Sung MH, Lee CH", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "23124353", "url": "https://glygen.org/publication/PubMed/23124353" } ] }, { "title": "N-acetylcysteine potentiates doxorubicin-induced ATM and p53 activation in ovarian cancer cells.", "journal": "International journal of oncology", "date": "2013", "authors": "Brum G, Carbone T, Still E, Correia V, Szulak K, Calianese D, Best C, Cammarata G, Higgins K, Ji F, Di W, Wan Y", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "23128467", "url": "https://glygen.org/publication/PubMed/23128467" } ] }, { "title": "Age-related susceptibility to apoptosis in human retinal pigment epithelial cells is triggered by disruption of p53-Mdm2 association.", "journal": "Investigative ophthalmology & visual science", "date": "2012", "authors": "Bhattacharya S, Chaum E, Johnson DA, Johnson LR", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "23139272", "url": "https://glygen.org/publication/PubMed/23139272" } ] }, { "title": "The deubiquitinating protein USP24 interacts with DDB2 and regulates DDB2 stability.", "journal": "Cell cycle (Georgetown, Tex.)", "date": "2012", "authors": "Zhang L, Lubin A, Chen H, Sun Z, Gong F", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "23159851", "url": "https://glygen.org/publication/PubMed/23159851" } ] }, { "title": "Analysis of p53, K-ras gene mutation & Helicobacter pylori infection in patients with gastric cancer & peptic ulcer disease at a tertiary care hospital in north India.", "journal": "The Indian journal of medical research", "date": "2012", "authors": "Saxena A, Shukla SK, Prasad KN, Ghoshal UC", "evidence": [ { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ { "type": "PubMed", "id": "23168708", "url": "https://glygen.org/publication/PubMed/23168708" } ] }, { "title": "STAT3 is involved in esophageal carcinogenesis through regulation of Oct-1.", "journal": "Carcinogenesis", "date": "2013", "authors": "Wang Z, Zhu S, Shen M, Liu J, Wang M, Li C, Wang Y, Deng A, Mei Q", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "23172665", "url": "https://glygen.org/publication/PubMed/23172665" } ] }, { "title": "A novel ER-localized transmembrane protein, EMC6, interacts with RAB5A and regulates cell autophagy.", "journal": "Autophagy", "date": "2013", "authors": "Li Y, Zhao Y, Hu J, Xiao J, Qu L, Wang Z, Ma D, Chen Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803205", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803205" } ], "reference": [ { "type": "PubMed", "id": "23182941", "url": "https://glygen.org/publication/PubMed/23182941" } ] }, { "title": "Regulation of phosphatidylinositol-5-phosphate signaling by Pin1 determines sensitivity to oxidative stress.", "journal": "Science signaling", "date": "2012", "authors": "Keune WJ, Jones DR, Bultsma Y, Sommer L, Zhou XZ, Lu KP, Divecha N", "evidence": [ { "database": "Reactome", "id": "R-HSA-6811555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811555" } ], "reference": [ { "type": "PubMed", "id": "23193159", "url": "https://glygen.org/publication/PubMed/23193159" } ] }, { "title": "Expression of cell proliferation cycle negative regulators in fibroblasts of an ischemic diabetic foot ulcer. A clinical case report.", "journal": "International wound journal", "date": "2013", "authors": "Berlanga-Acosta J, Mendoza-Mari Y, Martinez MD, Valdes-Perez C, Ojalvo AG, Armstrong DG", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "23194110", "url": "https://glygen.org/publication/PubMed/23194110" } ] }, { "title": "Association between HBX status, aflatoxin-induced R249S TP53 mutation and risk of hepatocellular carcinoma in a case-control study from Thailand.", "journal": "Cancer letters", "date": "2013", "authors": "Ortiz-Cuaran S, Villar S, Gouas D, Ferro G, Plymoth A, Khuhaprema T, Kalalak A, Sangrajrang S, Friesen MD, Groopman JD, Hainaut P", "evidence": [ { "database": "Entrez", "id": "7157", "url": "https://www.ncbi.nlm.nih.gov/gene/7157" } ], "reference": [ { "type": "PubMed", "id": "23200676", "url": "https://glygen.org/publication/PubMed/23200676" } ] }, { "title": "A novel Aurora-A-mediated phosphorylation of p53 inhibits its interaction with MDM2.", "journal": "Biochimica et biophysica acta", "date": "2013", "authors": "Hsueh KW, Fu SL, Chang CB, Chang YL, Lin CH", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "23201157", "url": "https://glygen.org/publication/PubMed/23201157" } ] }, { "title": "The origin of stroma surrounding epithelial ovarian cancer cells.", "journal": "International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists", "date": "2013", "authors": "Akahane T, Hirasawa A, Tsuda H, Kataoka F, Nishimura S, Tanaka H, Tominaga E, Nomura H, Chiyoda T, Iguchi Y, Yamagami W, Susumu N, Aoki D", "evidence": [ { "database": "Entrez", "id": "7157", "url": "https://www.ncbi.nlm.nih.gov/gene/7157" } ], "reference": [ { "type": "PubMed", "id": "23202778", "url": "https://glygen.org/publication/PubMed/23202778" } ] }, { "title": "Role of oxidative stress in hepatocarcinogenesis induced by hepatitis C virus.", "journal": "International journal of molecular sciences", "date": "2012", "authors": "Tsukiyama-Kohara K", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "23203124", "url": "https://glygen.org/publication/PubMed/23203124" } ] }, { "title": "GTSE1 is a microtubule plus-end tracking protein that regulates EB1-dependent cell migration.", "journal": "PloS one", "date": "2012", "authors": "Scolz M, Widlund PO, Piazza S, Bublik DR, Reber S, Peche LY, Ciani Y, Hubner N, Isokane M, Monte M, Ellenberg J, Hyman AA, Schneider C, Bird AW", "evidence": [ { "database": "Reactome", "id": "R-HSA-8852276", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8852276" } ], "reference": [ { "type": "PubMed", "id": 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Borodkin VS, van Aalten DM, Agnew B, Kuster B", "evidence": [ { "database": "O-GlcNAc Database", "id": "P04637", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P04637" } ], "reference": [ { "type": "PubMed", "id": "23301498", "url": "https://glygen.org/publication/PubMed/23301498" } ] }, { "title": "Polymorphism Arg72Pro of p53 confers susceptibility to squamous cell carcinoma of lungs in a North Indian population.", "journal": "DNA and cell biology", "date": "2013", "authors": "Tilak AR, Kumar S, Pant MC, Mathur N, Kumar A", "evidence": [ { "database": "Entrez", "id": "7157", "url": "https://www.ncbi.nlm.nih.gov/gene/7157" } ], "reference": [ { "type": "PubMed", "id": "23317414", "url": "https://glygen.org/publication/PubMed/23317414" } ] }, { "title": "Knockdown of RNF2 induces apoptosis by regulating MDM2 and p53 stability.", "journal": "Oncogene", "date": "2014", "authors": "Wen W, Peng C, Kim MO, Ho Jeong C, Zhu F, Yao K, Zykova T, Ma W, Carper A, Langfald A, Bode AM, Dong Z", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "23318437", "url": "https://glygen.org/publication/PubMed/23318437" } ] }, { "title": "FBH1 promotes DNA double-strand breakage and apoptosis in response to DNA replication stress.", "journal": "The Journal of cell biology", "date": "2013", "authors": "Jeong YT, Rossi M, Cermak L, Saraf A, Florens L, Washburn MP, Sung P, Schildkraut CL, Pagano M", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "23319600", "url": "https://glygen.org/publication/PubMed/23319600" } ] }, { "title": "Middle infrared radiation induces G2/M cell cycle arrest in A549 lung cancer cells.", "journal": "PloS one", "date": "2013", "authors": "Chang HY, Shih MH, Huang HC, Tsai SR, Juan HF, Lee SC", "evidence": [ { 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"P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "23342042", "url": "https://glygen.org/publication/PubMed/23342042" } ] }, { "title": "PRIMA-1 increases cisplatin sensitivity in chemoresistant ovarian cancer cells with p53 mutation: a requirement for Akt down-regulation.", "journal": "Journal of ovarian research", "date": "2013", "authors": "Kobayashi N, Abedini M, Sakuragi N, Tsang BK", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "23351152", "url": "https://glygen.org/publication/PubMed/23351152" } ] }, { "title": "Anacardic acid (6-pentadecylsalicylic acid) induces apoptosis of prostate cancer cells through inhibition of androgen receptor and activation of p53 signaling.", "journal": "Chinese journal of cancer research = Chung-kuo yen cheng yen chiu", "date": "2012", "authors": "Tan J, Chen B, He L, Tang Y, Jiang Z, Yin G, Wang J, Jiang X", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "23359208", "url": "https://glygen.org/publication/PubMed/23359208" } ] }, { "title": "Computational identification of a transiently open L1/S3 pocket for reactivation of mutant p53.", "journal": "Nature communications", "date": "2013", "authors": "Wassman CD, Baronio R, Demir O, Wallentine BD, Chen CK, Hall LV, Salehi F, Lin DW, Chung BP, Hatfield GW, Richard Chamberlin A, Luecke H, Lathrop RH, Kaiser P, Amaro RE", "evidence": [ { "database": "Entrez", "id": "7157", "url": "https://www.ncbi.nlm.nih.gov/gene/7157" } ], "reference": [ { "type": "PubMed", "id": "23360998", "url": "https://glygen.org/publication/PubMed/23360998" } ] }, { "title": "ASPP1/2 regulate p53-dependent death of retinal ganglion cells through PUMA and Fas/CD95 activation in vivo.", "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "date": "2013", "authors": "Wilson AM, Morquette B, Abdouh M, Unsain N, Barker PA, Feinstein E, Bernier G, Di Polo A", "evidence": [ { "database": "Reactome", "id": "R-HSA-139915", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-139915" } ], "reference": [ { "type": "PubMed", "id": "23365256", "url": "https://glygen.org/publication/PubMed/23365256" } ] }, { "title": "Identification of the E3 deubiquitinase ubiquitin-specific peptidase 21 (USP21) as a positive regulator of the transcription factor GATA3.", "journal": "The Journal of biological chemistry", "date": "2013", "authors": "Zhang J, Chen C, Hou X, Gao Y, Lin F, Yang J, Gao Z, Pan L, Tao L, Wen C, Yao Z, Tsun A, Shi G, Li B", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "23395819", "url": 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Natl. Acad. Sci. U.S.A.", "date": "2013", "authors": "Taya Y., Arnal S.M., Kitabayashi I., Laptenko O., Prives C., Rokudai S.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" }, { "database": "Reactome", "id": "R-HSA-6804758", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804758" } ], "reference": [ { "type": "PubMed", "id": "23431171", "url": "https://glygen.org/publication/PubMed/23431171" } ] }, { "title": "Asperolide A, a marine-derived tetranorditerpenoid, induces G2/M arrest in human NCI-H460 lung carcinoma cells, is mediated by p53-p21 stabilization and modulated by Ras/Raf/MEK/ERK signaling pathway.", "journal": "Marine drugs", "date": "2013", "authors": "Lv C, Sun W, Sun H, Wei S, Chen R, Wang B, Huang C", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "23434831", "url": "https://glygen.org/publication/PubMed/23434831" } ] }, { "title": "Autophagy and cellular senescence mediated by Sox2 suppress malignancy of cancer cells.", "journal": "PloS one", "date": "2013", "authors": "Cho YY, Kim DJ, Lee HS, Jeong CH, Cho EJ, Kim MO, Byun S, Lee KY, Yao K, Carper A, Langfald A, Bode AM, Dong Z", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "23451179", "url": "https://glygen.org/publication/PubMed/23451179" } ] }, { "title": "Mutant B-RAF-Mcl-1 survival signaling depends on the STAT3 transcription factor.", "journal": "Oncogene", "date": "2014", "authors": "Becker TM, Boyd SC, Mijatov B, Gowrishankar K, Snoyman S, Pupo GM, Scolyer RA, Mann GJ, Kefford RF, Zhang XD, Rizos H", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", 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"R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "23486064", "url": "https://glygen.org/publication/PubMed/23486064" } ] }, { "title": "Mechanisms of ceramide-induced COX-2-dependent apoptosis in human ovarian cancer OVCAR-3 cells partially overlapped with resveratrol.", "journal": "Journal of cellular biochemistry", "date": "2013", "authors": "Lin HY, Delmas D, Vang O, Hsieh TC, Lin S, Cheng GY, Chiang HL, Chen CE, Tang HY, Crawford DR, Whang-Peng J, Hwang J, Liu LF, Wu JM", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "23495037", "url": "https://glygen.org/publication/PubMed/23495037" } ] }, { "title": "Subamolide a induces mitotic catastrophe accompanied by apoptosis in human lung cancer cells.", "journal": "Evidence-based complementary and alternative medicine : eCAM", "date": "2013", "authors": "Hung JY, Wen CW, Hsu YL, Lin ES, Huang MS, Chen CY, Kuo PL", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "23533526", "url": "https://glygen.org/publication/PubMed/23533526" } ] }, { "title": "Tumor suppressor protein Pdcd4 interacts with Daxx and modulates the stability of Daxx and the Hipk2-dependent phosphorylation of p53 at serine 46.", "journal": "Oncogenesis", "date": "2013", "authors": "Kumar N, Wethkamp N, Waters LC, Carr MD, Klempnauer KH", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "23536002", "url": "https://glygen.org/publication/PubMed/23536002" } ] }, { "title": "Association between p53 Pro72Arg polymorphism and prostate cancer risk: a meta-analysis.", "journal": "Journal of biomedical research", "date": "2011", "authors": "Zhang L, Shao N, Yu Q, Hua L, Mi Y, Feng N", "evidence": [ { "database": "Entrez", "id": "7157", "url": "https://www.ncbi.nlm.nih.gov/gene/7157" } ], "reference": [ { "type": "PubMed", "id": "23554668", "url": "https://glygen.org/publication/PubMed/23554668" } ] }, { "title": "Inhibition of p53-dependent, but not p53-independent, cell death by U19 protein from human herpesvirus 6B.", "journal": "PloS one", "date": "2013", "authors": "Kofod-Olsen E, Moller JM, Schleimann MH, Bundgaard B, Bak RO, Oster B, Mikkelsen JG, Hupp T, Hollsberg P", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "23555634", "url": "https://glygen.org/publication/PubMed/23555634" } ] }, { "title": "Tissue inhibitor of metalloproteinase 1 is preferentially expressed in Th1 and Th17 T-helper cell subsets and is a direct STAT target gene.", "journal": "PloS one", "date": "2013", "authors": "Adamson A, Ghoreschi K, Rittler M, Chen Q, Sun HW, Vahedi G, Kanno Y, Stetler-Stevenson WG, O'Shea JJ, Laurence A", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "23555662", "url": "https://glygen.org/publication/PubMed/23555662" } ] }, { "title": "Zoledronic acid produces combinatory anti-tumor effects with cisplatin on mesothelioma by increasing p53 expression levels.", "journal": "PloS one", "date": "2013", "authors": "Okamoto S, Jiang Y, Kawamura K, Shingyoji M, Fukamachi T, Tada Y, Takiguchi Y, Tatsumi K, Shimada H, Hiroshima K, Kobayashi H, Tagawa M", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "23555949", "url": "https://glygen.org/publication/PubMed/23555949" } ] }, { "title": "Identification of microRNA-mRNA functional interactions in UVB-induced senescence of human diploid fibroblasts.", "journal": "BMC genomics", "date": "2013", "authors": "Greussing R, Hackl M, Charoentong P, Pauck A, Monteforte R, Cavinato M, Hofer E, Scheideler M, Neuhaus M, Micutkova L, Mueck C, Trajanoski Z, Grillari J, Jansen-Durr P", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "23557329", "url": "https://glygen.org/publication/PubMed/23557329" } ] }, { "title": "Actin polymerization negatively regulates p53 function by impairing its nuclear import in response to DNA damage.", "journal": "PloS one", "date": "2013", "authors": "Wang L, Wang M, Wang S, Qi T, Guo L, Li J, Qi W, Ampah KK, Ba X, Zeng X", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": 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B, Blonska M, Gorjestani S, Yan M, Tian Q, Zhang DE, Lin X, Dong C", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "23825189", "url": "https://glygen.org/publication/PubMed/23825189" } ] }, { "title": "MDM2 Inhibits Axin-Induced p53 Activation Independently of its E3 Ligase Activity.", "journal": "PloS one", "date": "2013", "authors": "He Y, Lian G, Lin S, Ye Z, Li Q", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "23826318", "url": "https://glygen.org/publication/PubMed/23826318" } ] }, { "title": "OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.", "journal": "Cell", "date": "2013", "authors": "Mevissen TE, Hospenthal MK, Geurink PP, Elliott PR, Akutsu M, Arnaudo N, Ekkebus R, Kulathu Y, Wauer T, El Oualid F, Freund SM, Ovaa H, Komander D", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689896", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689896" } ], "reference": [ { "type": "PubMed", "id": "23827681", "url": "https://glygen.org/publication/PubMed/23827681" } ] }, { "title": "Association between TP53 R249S mutation and polymorphisms in TP53 intron 1 in hepatocellular carcinoma.", "journal": "Genes, chromosomes & cancer", "date": "2013", "authors": "Ortiz-Cuaran S, Cox D, Villar S, Friesen MD, Durand G, Chabrier A, Khuhaprema T, Sangrajrang S, Ognjanovic S, Groopman JD, Hainaut P, Le Calvez-Kelm F", "evidence": [ { "database": "Entrez", "id": "7157", "url": "https://www.ncbi.nlm.nih.gov/gene/7157" } ], "reference": [ { "type": "PubMed", "id": "23836507", "url": "https://glygen.org/publication/PubMed/23836507" } ] }, { "title": "Distinct single cell signal transduction signatures in leukocyte subsets stimulated with khat extract, amphetamine-like cathinone, cathine or norephedrine.", "journal": "BMC pharmacology & toxicology", "date": "2013", "authors": "Bredholt T, Ersvaer E, Erikstein BS, Sulen A, Reikvam H, Aarstad HJ, Johannessen AC, Vintermyr OK, Bruserud O, Gjertsen BT", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "23845085", "url": "https://glygen.org/publication/PubMed/23845085" } ] }, { "title": "Cheliensisin A inhibits EGF-induced cell transformation with stabilization of p53 protein via a hydrogen peroxide/Chk1-dependent axis.", "journal": "Cancer prevention research (Philadelphia, Pa.)", "date": "2013", "authors": "Zhang J, Gao G, Chen L, Deng X, Li J, Yu Y, Zhang D, Li F, Zhang M, Zhao Q, Huang C", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "23852422", "url": "https://glygen.org/publication/PubMed/23852422" } ] }, { "title": "The exomes of the NCI-60 panel: a genomic resource for cancer biology and systems pharmacology.", "journal": "Cancer research", "date": "2013", "authors": "Abaan OD, Polley EC, Davis SR, Zhu YJ, Bilke S, Walker RL, Pineda M, Gindin Y, Jiang Y, Reinhold WC, Holbeck SL, Simon RM, Doroshow JH, Pommier Y, Meltzer PS", "evidence": [ { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ { "type": "PubMed", "id": "23856246", "url": "https://glygen.org/publication/PubMed/23856246" } ] }, { "title": "Stepwise activation of the ATR signaling pathway upon increasing replication stress impacts fragile site integrity.", "journal": "PLoS genetics", "date": "2013", "authors": "Koundrioukoff S, Carignon S, Techer H, Letessier A, Brison O, Debatisse M", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "23874235", "url": "https://glygen.org/publication/PubMed/23874235" } ] }, { "title": "Levels of pro-apoptotic regulator Bad and anti-apoptotic regulator Bcl-xL determine the type of the apoptotic logic gate.", "journal": "BMC systems biology", "date": "2013", "authors": "Bogdal MN, Hat B, Kochanczyk M, Lipniacki T", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "23883471", "url": "https://glygen.org/publication/PubMed/23883471" } ] }, { "title": "Hepatitis B virus genetic variation and TP53 R249S mutation in patients with hepatocellular carcinoma in Thailand.", "journal": "Asian Pacific journal of cancer prevention : APJCP", "date": "2013", "authors": "Thongbai C, Sa-nguanmoo P, Kranokpiruk P, Poovorawan K, Poovorawan Y, Tangkijvanich P", "evidence": [ { 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and with ageing.", "journal": "Nature", "date": "1990", "authors": "Hastie ND, Dempster M, Dunlop MG, Thompson AM, Green DK, Allshire RC", "evidence": [ { "database": "Reactome", "id": "R-HSA-2559586", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2559586" } ], "reference": [ { "type": "PubMed", "id": "2392154", "url": "https://glygen.org/publication/PubMed/2392154" } ] }, { "title": "TRIAP1/PRELI complexes prevent apoptosis by mediating intramitochondrial transport of phosphatidic acid.", "journal": "Cell metabolism", "date": "2013", "authors": "Potting C, Tatsuta T, Konig T, Haag M, Wai T, Aaltonen MJ, Langer T", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803204", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803204" } ], "reference": [ { "type": "PubMed", "id": "23931759", "url": "https://glygen.org/publication/PubMed/23931759" } ] }, { "title": "Retinoblastoma protein regulates the crosstalk between autophagy and apoptosis, and favors glioblastoma resistance to etoposide.", "journal": "Cell death & disease", "date": "2013", "authors": "Biasoli D, Kahn SA, Cornelio TA, Furtado M, Campanati L, Chneiweiss H, Moura-Neto V, Borges HL", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "23949216", "url": "https://glygen.org/publication/PubMed/23949216" } ] }, { "title": "Redistribution of the Lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence.", "journal": "Genes & development", "date": "2013", "authors": "Sadaie M, Salama R, Carroll T, Tomimatsu K, Chandra T, Young AR, Narita M, Perez-Mancera PA, Bennett DC, Chong H, Kimura H, Narita M", "evidence": [ { "database": "Reactome", "id": "R-HSA-2559584", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2559584" } ], "reference": [ { "type": "PubMed", "id": "23964094", "url": "https://glygen.org/publication/PubMed/23964094" } ] }, { "title": "p53 increases MHC class I expression by upregulating the endoplasmic reticulum aminopeptidase ERAP1.", "journal": "Nature communications", "date": "2013", "authors": "Wang B, Niu D, Lai L, Ren EC", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "23965983", "url": "https://glygen.org/publication/PubMed/23965983" } ] }, { "title": "STAT3 regulates MMP3 in heme-induced endothelial cell apoptosis.", "journal": "PloS one", "date": "2013", "authors": "Liu M, Wilson NO, Hibbert JM, Stiles JK", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "23967200", "url": "https://glygen.org/publication/PubMed/23967200" } ] }, { "title": "Overexpression and promoter mutation of the TERT gene in malignant pleural mesothelioma.", "journal": "Oncogene", "date": "2014", "authors": "Tallet A, Nault JC, Renier A, Hysi I, Galateau-Salle F, Cazes A, Copin MC, Hofman P, Andujar P, Le Pimpec-Barthes F, Zucman-Rossi J, Jaurand MC, Jean D", "evidence": [ { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ { "type": "PubMed", "id": "23975423", "url": "https://glygen.org/publication/PubMed/23975423" } ] }, { "title": "Increased Plin2 expression in human skeletal muscle is associated with sarcopenia and muscle weakness.", "journal": "PloS one", "date": "2013", "authors": "Conte M, Vasuri F, Trisolino G, Bellavista E, Santoro A, Degiovanni A, Martucci E, D'Errico-Grigioni A, Caporossi D, Capri M, Maier AB, Seynnes O, Barberi L, Musaro A, Narici MV, Franceschi C, Salvioli S", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "23977392", "url": "https://glygen.org/publication/PubMed/23977392" } ] }, { "title": "A model of sensitivity and resistance to histone deacetylase inhibitors in diffuse large B cell lymphoma: Role of cyclin-dependent kinase inhibitors.", "journal": "Cancer biology & therapy", "date": "2013", "authors": "Tula-Sanchez AA, Havas AP, Alonge PJ, Klein ME, Doctor SR, Pinkston W, Glinsmann-Gibson BJ, Rimsza LM, Smith CL", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "23982416", "url": "https://glygen.org/publication/PubMed/23982416" } ] }, { "title": "CSF1 is a novel p53 target gene whose protein product functions in a feed-forward manner to suppress apoptosis and enhance p53-mediated growth arrest.", "journal": "PloS one", "date": "2013", "authors": "Azzam G, Wang X, Bell D, Murphy ME", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "24019961", "url": "https://glygen.org/publication/PubMed/24019961" } ] }, { "title": "Oxygen dependence of nitric oxide-mediated signaling.", "journal": "Redox biology", "date": "2013", "authors": "Hickok JR, Vasudevan D, Jablonski K, Thomas DD", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "24024154", "url": "https://glygen.org/publication/PubMed/24024154" } ] }, { "title": "Dominant effects of Delta40p53 on p53 function and melanoma cell fate.", "journal": "The Journal of investigative dermatology", "date": "2014", "authors": "Takahashi R, Markovic SN, Scrable HJ", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "24037342", "url": "https://glygen.org/publication/PubMed/24037342" } ] }, { "title": "Wild type p53 transcriptionally represses the SALL2 transcription factor under genotoxic stress.", "journal": "PloS one", "date": "2013", "authors": "Farkas C, Martins CP, Escobar D, Hepp MI, Castro AF, Evan G, Gutierrez JL, Warren R, Donner DB, Pincheira R", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "24040083", "url": "https://glygen.org/publication/PubMed/24040083" } ] }, { "title": "p53 regulates Period2 expression and the circadian clock.", "journal": "Nat. Commun.", "date": "2013", "authors": "Lee C.C., Miki T., Zhao Z., Matsumoto T.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "24051492", "url": "https://glygen.org/publication/PubMed/24051492" } ] }, { "title": "Deubiquitinating enzyme Usp12 is a novel co-activator of the androgen receptor.", "journal": "The Journal of biological chemistry", "date": "2013", "authors": "Burska UL, Harle VJ, Coffey K, Darby S, Ramsey H, O'Neill D, Logan IR, Gaughan L, Robson CN", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "24056413", "url": "https://glygen.org/publication/PubMed/24056413" } ] }, { "title": "Glucose-6-phosphate dehydrogenase: a biomarker and potential therapeutic target for cancer.", "journal": "Anti-cancer agents in medicinal chemistry", "date": "2014", "authors": "Zhang C, Zhang Z, Zhu Y, Qin S", "evidence": [ { "database": "Reactome", "id": "R-HSA-5628897", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5628897" } ], "reference": [ { "type": "PubMed", "id": "24066844", "url": "https://glygen.org/publication/PubMed/24066844" } ] }, { "title": "Ribosomal S6 Kinase 2 (RSK2) maintains genomic stability by activating the Atm/p53-dependent DNA damage pathway.", "journal": "PloS one", "date": "2013", "authors": "Lim HC, Xie L, Zhang W, Li R, Chen ZC, Wu GZ, Cui SS, Tan EK, Zeng L", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "24086335", "url": "https://glygen.org/publication/PubMed/24086335" } ] }, { "title": "Depletion of the adaptor protein NCK increases UV-induced p53 phosphorylation and promotes apoptosis.", "journal": "PloS one", "date": "2013", "authors": "Errington TM, Macara IG", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "24086708", "url": "https://glygen.org/publication/PubMed/24086708" } ] }, { "title": "Progressive changes in chromatin structure and DNA damage response signals in bone marrow and peripheral blood during myelomagenesis.", "journal": "Leukemia", "date": "2014", "authors": "Gkotzamanidou M, Terpos E, Bamia C, Kyrtopoulos SA, Sfikakis PP, Dimopoulos MA, Souliotis VL", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "24089038", "url": "https://glygen.org/publication/PubMed/24089038" } ] }, { "title": "p53-dependent gene repression through p21 is mediated by recruitment of E2F4 repression complexes.", "journal": "Oncogene", "date": "2014", "authors": "Benson EK, Mungamuri SK, Attie O, Kracikova M, Sachidanandam R, Manfredi JJ, Aaronson SA", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804114", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804114" } ], "reference": [ { "type": "PubMed", "id": "24096481", "url": "https://glygen.org/publication/PubMed/24096481" } ] }, { "title": "p53's choice of myocardial death or survival: Oxygen protects infarct myocardium by recruiting p53 on NOS3 promoter through regulation of p53-Lys(118) acetylation.", "journal": "EMBO molecular medicine", "date": "2013", "authors": "Gogna R, Madan E, Khan M, Pati U, Kuppusamy P", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "24096875", "url": "https://glygen.org/publication/PubMed/24096875" } ] }, { "title": "The signal transducers Stat1 and Stat3 and their novel target Jmjd3 drive the expression of inflammatory genes in microglia.", "journal": "Journal of molecular medicine (Berlin, Germany)", "date": "2014", "authors": "Przanowski P, Dabrowski M, Ellert-Miklaszewska A, Kloss M, Mieczkowski J, Kaza B, Ronowicz A, Hu F, Piotrowski A, Kettenmann H, Komorowski J, Kaminska B", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "24097101", "url": "https://glygen.org/publication/PubMed/24097101" } ] }, { "title": "Genetic lesions associated with chronic lymphocytic leukemia transformation to Richter syndrome.", "journal": "The Journal of experimental medicine", "date": "2013", "authors": "Fabbri G, Khiabanian H, Holmes AB, Wang J, Messina M, Mullighan CG, Pasqualucci L, Rabadan R, Dalla-Favera R", "evidence": [ { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ { "type": "PubMed", "id": "24127483", "url": "https://glygen.org/publication/PubMed/24127483" } 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"https://glygen.org/publication/PubMed/24129246" } ] }, { "title": "The genetic landscape of anaplastic astrocytoma.", "journal": "Oncotarget", "date": "2014", "authors": "Killela PJ, Pirozzi CJ, Reitman ZJ, Jones S, Rasheed BA, Lipp E, Friedman H, Friedman AH, He Y, McLendon RE, Bigner DD, Yan H", "evidence": [ { "database": "dbSNP", "id": "rs28934571", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs28934571" } ], "reference": [ { "type": "PubMed", "id": "24140581", "url": "https://glygen.org/publication/PubMed/24140581" } ] }, { "title": "Synthesis, characterization, and anticancer activity of ruthenium(II)-beta-carboline complex.", "journal": "European journal of medicinal chemistry", "date": "2013", "authors": "Chen Y, Qin MY, Wu JH, Wang L, Chao H, Ji LN, Xu AL", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "24141202", "url": "https://glygen.org/publication/PubMed/24141202" } ] }, { "title": "Autophosphorylation and Pin1 binding coordinate DNA damage-induced HIPK2 activation and cell death.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2013", "authors": "Bitomsky N, Conrad E, Moritz C, Polonio-Vallon T, Sombroek D, Schultheiss K, Glas C, Greiner V, Herbel C, Mantovani F, del Sal G, Peri F, Hofmann TG", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804756", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804756" } ], "reference": [ { "type": "PubMed", "id": "24145406", "url": "https://glygen.org/publication/PubMed/24145406" } ] }, { "title": "Contribution of BubR1 to oxidative stress-induced aneuploidy in p53-deficient cells.", "journal": "Cancer medicine", "date": "2013", "authors": "Ikawa-Yoshida A, Ando K, Oki E, Saeki H, Kumashiro R, Taketani K, Ida S, Tokunaga E, Kitao H, Morita M, Maehara Y", "evidence": [ { "database": 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Ljungman M", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "24194914", "url": "https://glygen.org/publication/PubMed/24194914" } ] }, { "title": "Acetylation of lysine 382 and phosphorylation of serine 392 in p53 modulate the interaction between p53 and MDC1 in vitro.", "journal": "PloS one", "date": "2013", "authors": "Shahar OD, Gabizon R, Feine O, Alhadeff R, Ganoth A, Argaman L, Shimshoni E, Friedler A, Goldberg M", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "24194938", "url": "https://glygen.org/publication/PubMed/24194938" } ] }, { "title": "SPATA12 and its possible role in DNA damage induced by ultraviolet-C.", "journal": "PloS one", "date": "2013", "authors": "Zhang Y, Yang L, Lin Y, Rong Z, Liu X, Li D", "evidence": [ { 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Zhang B, Han Y, Clotaire DZ, Wang C, Chang H, Luo H, Ren X, Lei M", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "24244715", "url": "https://glygen.org/publication/PubMed/24244715" } ] }, { "title": "p53 tumor suppressor protein stability and transcriptional activity are targeted by Kaposi's sarcoma-associated herpesvirus-encoded viral interferon regulatory factor 3.", "journal": "Molecular and cellular biology", "date": "2014", "authors": "Baresova P, Musilova J, Pitha PM, Lubyova B", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "24248600", "url": "https://glygen.org/publication/PubMed/24248600" } ] }, { "title": "N-myc downstream-regulated gene 1: Diverse and complicated functions in human hepatocellular carcinoma (Review).", "journal": "Oncology letters", "date": "2013", "authors": "Song Y, Cao L", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803205", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803205" } ], "reference": [ { "type": "PubMed", "id": "24260043", "url": "https://glygen.org/publication/PubMed/24260043" } ] }, { "title": "Ubiquitin-specific proteases 25 negatively regulates virus-induced type I interferon signaling.", "journal": "PloS one", "date": "2013", "authors": "Zhong H, Wang D, Fang L, Zhang H, Luo R, Shang M, Ouyang C, Ouyang H, Chen H, Xiao S", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "24260525", "url": "https://glygen.org/publication/PubMed/24260525" } ] }, { "title": "The emerging role of p53 in exercise metabolism.", "journal": "Sports medicine (Auckland, N.Z.)", "date": "2014", "authors": "Bartlett JD, Close GL, Drust B, Morton JP", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "24264057", "url": "https://glygen.org/publication/PubMed/24264057" } ] }, { "title": "Differential responses to genotoxic agents between induced pluripotent stem cells and tumor cell lines.", "journal": "Journal of hematology & oncology", "date": "2013", "authors": "Lu Y, Xu D, Zhou J, Ma Y, Jiang Y, Zeng W, Dai W", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "24283650", "url": "https://glygen.org/publication/PubMed/24283650" } ] }, { "title": "Nutlin-3 downregulates p53 phosphorylation on serine392 and induces apoptosis in hepatocellular carcinoma cells.", "journal": "BMB reports", "date": "2014", "authors": "Shi X, Liu J, Ren L, Mao N, Tan F, Ding N, Yang J, Li M", "evidence": [ { 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"P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "24313628", "url": "https://glygen.org/publication/PubMed/24313628" } ] }, { "title": "T-type Ca2+ channel inhibition induces p53-dependent cell growth arrest and apoptosis through activation of p38-MAPK in colon cancer cells.", "journal": "Molecular cancer research : MCR", "date": "2014", "authors": "Dziegielewska B, Brautigan DL, Larner JM, Dziegielewski J", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "24362252", "url": "https://glygen.org/publication/PubMed/24362252" } ] }, { "title": "p53/TAp63 and AKT regulate mammalian target of rapamycin complex 1 (mTORC1) signaling through two independent parallel pathways in the presence of DNA damage.", "journal": "The Journal of biological chemistry", "date": "2014", "authors": "Cam M, Bid HK, Xiao L, Zambetti GP, Houghton PJ, Cam H", "evidence": [ { "database": "Reactome", "id": "R-HSA-5628897", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5628897" } ], "reference": [ { "type": "PubMed", "id": "24366874", "url": "https://glygen.org/publication/PubMed/24366874" } ] }, { "title": "Reactive oxygen species mediate Epstein-Barr virus reactivation by N-methyl-N'-nitro-N-nitrosoguanidine.", "journal": "PloS one", "date": "2013", "authors": "Huang SY, Fang CY, Wu CC, Tsai CH, Lin SF, Chen JY", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "24376853", "url": "https://glygen.org/publication/PubMed/24376853" } ] }, { "title": "Induction of amphiregulin by p53 promotes apoptosis via control of microRNA biogenesis in response to DNA damage.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2014", "authors": "Taira N, Yamaguchi T, Kimura J, Lu ZG, Fukuda S, Higashiyama S, Ono M, Yoshida K", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "24379358", "url": "https://glygen.org/publication/PubMed/24379358" } ] }, { "title": "Topoisomerase I inhibitor, camptothecin, induces apoptogenic signaling in human embryonic stem cells.", "journal": "Stem cell research", "date": "2014", "authors": "Garcia CP, Videla Richardson GA, Romorini L, Miriuka SG, Sevlever GE, Scassa ME", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "24380814", "url": "https://glygen.org/publication/PubMed/24380814" } ] }, { "title": "TIGAR, TIGAR, burning bright.", "journal": "Cancer & metabolism", "date": "2014", "authors": "Lee P, Vousden KH, Cheung EC", "evidence": [ { 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is mediated by increased DNA binding activity and increased interaction between p53 and Sp1 via phosphorylation during replicative senescence of human embryonic fibroblasts.", "journal": "Molecular biology reports", "date": "2014", "authors": "Kim HS, Heo JI, Park SH, Shin JY, Kang HJ, Kim MJ, Kim SC, Kim J, Park JB, Lee JY", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "24445528", "url": "https://glygen.org/publication/PubMed/24445528" } ] }, { "title": "Methylseleninic acid suppresses pancreatic cancer growth involving multiple pathways.", "journal": "Nutrition and cancer", "date": "2014", "authors": "Wang L, Hu H, Wang Z, Xiong H, Cheng Y, Liao JD, Deng Y, Lu J", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "24447148", "url": "https://glygen.org/publication/PubMed/24447148" } ] }, { "title": "Inhibition of human lung cancer cell proliferation and survival by wine.", "journal": "Cancer cell international", "date": "2014", "authors": "Barron CC, Moore J, Tsakiridis T, Pickering G, Tsiani E", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "24456610", "url": "https://glygen.org/publication/PubMed/24456610" } ] }, { "title": "Prevalence of aflatoxin induced p53 mutation at codon 249 (R249s) in hepatocellular carcinoma patients with and without hepatitis B surface antigen (HBsAg).", "journal": "Asian Pacific journal of cancer prevention : APJCP", "date": "2013", "authors": "Chittmittrapap S, Chieochansin T, Chaiteerakij R, Treeprasertsuk S, Klaikaew N, Tangkijvanich P, Komolmit P, Poovorawan Y", "evidence": [ { "database": "Entrez", "id": "7157", "url": 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Wikenheiser-Brokamp KA, Wise-Draper TM, Wells SI", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "24608431", "url": "https://glygen.org/publication/PubMed/24608431" } ] }, { "title": "Structural basis for ovarian tumor domain-containing protein 1 (OTU1) binding to p97/valosin-containing protein (VCP).", "journal": "The Journal of biological chemistry", "date": "2014", "authors": "Kim SJ, Cho J, Song EJ, Kim SJ, Kim HM, Lee KE, Suh SW, Kim EE", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689896", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689896" } ], "reference": [ { "type": "PubMed", "id": "24610782", "url": "https://glygen.org/publication/PubMed/24610782" } ] }, { "title": "Redox control of p53 in the transcriptional regulation of TGF-beta1 target genes through SMAD cooperativity.", "journal": "Cellular signalling", "date": "2014", "authors": "Overstreet JM, Samarakoon R, Meldrum KK, Higgins PJ", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "24613410", "url": "https://glygen.org/publication/PubMed/24613410" } ] }, { "title": "Classification of a frameshift/extended and a stop mutation in WT1 as gain-of-function mutations that activate cell cycle genes and promote Wilms tumour cell proliferation.", "journal": "Human molecular genetics", "date": "2014", "authors": "Busch M, Schwindt H, Brandt A, Beier M, Gorldt N, Romaniuk P, Toska E, Roberts S, Royer HD, Royer-Pokora B", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "24619359", "url": "https://glygen.org/publication/PubMed/24619359" } ] }, { "title": "Kirenol, a compound from Herba Siegesbeckiae, induces apoptosis in human chronic myeloid leukemia K562 cells.", "journal": "Die Pharmazie", "date": "2014", "authors": "Lu Y, Qian R, Xiao J, Xu D, Fu H, Chen Y", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "24640606", "url": "https://glygen.org/publication/PubMed/24640606" } ] }, { "title": "DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. [Corrected].", "journal": "J. Natl. Cancer Inst.", "date": "2014", "authors": "Morelli F., Polato F., Marchini S., Rusconi P., Boeri M., Broggini M., Castiglioni V., Musi A., Scanziani E., Torri V., Zangrossi S.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "24652652", "url": "https://glygen.org/publication/PubMed/24652652" } ] }, { "title": "Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2.", "journal": "Molecular cell", "date": "2014", "authors": "Rao F, Cha J, Xu J, Xu R, Vandiver MS, Tyagi R, Tokhunts R, Koldobskiy MA, Fu C, Barrow R, Wu M, Fiedler D, Barrow JC, Snyder SH", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "24657168", "url": "https://glygen.org/publication/PubMed/24657168" } ] }, { "title": "The structure and 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"journal": "Scientific reports", "date": "2014", "authors": "Zhang Q, Liu J, Liu B, Xia J, Chen N, Chen X, Cao Y, Zhang C, Lu C, Li M, Zhu R", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "24717393", "url": "https://glygen.org/publication/PubMed/24717393" } ] }, { "title": "The tumor suppressor PTEN interacts with p53 in hereditary cancer (Review).", "journal": "International journal of oncology", "date": "2014", "authors": "Nakanishi A, Kitagishi Y, Ogura Y, Matsuda S", "evidence": [ { "database": "Reactome", "id": "R-HSA-5628897", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5628897" } ], "reference": [ { "type": "PubMed", "id": "24718924", "url": "https://glygen.org/publication/PubMed/24718924" } ] }, { "title": "HDAC inhibitors induce apoptosis but not cellular senescence in Gadd45alpha-deficient E1A+Ras cells.", "journal": "The international 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"https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "24896179", "url": "https://glygen.org/publication/PubMed/24896179" } ] }, { "title": "Expression of survivin and p53 modulates honokiol-induced apoptosis in colorectal cancer cells.", "journal": "Journal of cellular biochemistry", "date": "2014", "authors": "Lai YJ, Lin CI, Wang CL, Chao JI", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "24905183", "url": "https://glygen.org/publication/PubMed/24905183" } ] }, { "title": "Rapamycin prevents strong phosphorylation of p53 on serine 46 and attenuates activation of the p53 pathway in A549 lung cancer cells exposed to actinomycin D.", "journal": "Mechanisms of ageing and development", "date": "2014", "authors": "Krzesniak M, Zajkowicz A, Matuszczyk I, Rusin M", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "24915467", "url": "https://glygen.org/publication/PubMed/24915467" } ] }, { "title": "Leptin is an anti-apoptotic effector in placental cells involving p53 downregulation.", "journal": "PloS one", "date": "2014", "authors": "Toro AR, Maymo JL, Ibarbalz FM, Perez-Perez A, Maskin B, Faletti AG, Sanchez-Margalet V, Varone CL", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "24922063", "url": "https://glygen.org/publication/PubMed/24922063" } ] }, { "title": "Capsaicin-induced activation of p53-SMAR1 auto-regulatory loop down-regulates VEGF in non-small cell lung cancer to restrain angiogenesis.", "journal": "PloS one", "date": "2014", "authors": "Chakraborty S, Adhikary A, Mazumdar M, Mukherjee S, Bhattacharjee P, Guha D, Choudhuri T, Chattopadhyay S, Sa G, Sen A, Das T", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "24926985", "url": "https://glygen.org/publication/PubMed/24926985" } ] }, { "title": "Critical role for p53-serine 15 phosphorylation in stimulating transactivation at p53-responsive promoters.", "journal": "Nucleic acids research", "date": "2014", "authors": "Loughery J, Cox M, Smith LM, Meek DW", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "24928858", "url": "https://glygen.org/publication/PubMed/24928858" } ] }, { "title": "MIF family members cooperatively inhibit p53 expression and activity.", "journal": "PloS one", "date": "2014", "authors": "Brock SE, Rendon BE, Xin D, Yaddanapudi K, Mitchell RA", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "24932684", "url": "https://glygen.org/publication/PubMed/24932684" } ] }, { "title": "Interaction between ROS dependent DNA damage, mitochondria and p38 MAPK underlies senescence of human adult stem cells.", "journal": "Aging", "date": "2014", "authors": "Borodkina A, Shatrova A, Abushik P, Nikolsky N, Burova E", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "24934860", "url": "https://glygen.org/publication/PubMed/24934860" } ] }, { "title": "Histone deacetylase 2 and N-Myc reduce p53 protein phosphorylation at serine 46 by repressing gene transcription of tumor protein 53-induced nuclear protein 1.", "journal": "Oncotarget", "date": "2014", "authors": "Shahbazi J, Scarlett CJ, Norris MD, Liu B, Haber M, Tee AE, Carrier A, Biankin AV, London WB, Marshall GM, Lock RB, Liu T", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "24952595", "url": "https://glygen.org/publication/PubMed/24952595" } ] }, { "title": "Modulation of radiation injury response in retinal endothelial cells by quinic acid derivative KZ-41 involves p38 MAPK.", "journal": "PloS one", "date": "2014", "authors": "Toutounchian JJ, Steinle JJ, Makena PS, Waters CM, Wilson MW, Haik BG, Miller DD, Yates CR", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "24956278", "url": "https://glygen.org/publication/PubMed/24956278" } ] }, { "title": "Sodium dichloroacetate exhibits anti-leukemic activity in B-chronic lymphocytic leukemia (B-CLL) and synergizes with the p53 activator Nutlin-3.", "journal": "Oncotarget", "date": "2014", "authors": "Agnoletto C, Melloni E, Casciano F, Rigolin GM, Rimondi E, Celeghini C, Brunelli L, Cuneo A, Secchiero P, Zauli G", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "24962518", "url": "https://glygen.org/publication/PubMed/24962518" } ] }, { "title": "Synergistic apoptosis-inducing effects on A375 human melanoma cells of natural borneol and curcumin.", "journal": "PloS one", "date": "2014", "authors": "Chen J, Li L, Su J, Li B, Chen T, Wong YS", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "24971451", "url": "https://glygen.org/publication/PubMed/24971451" } ] }, { "title": "Chromatin structure, transcriptional activity and DNA repair efficiency affect the outcome of chemotherapy in multiple myeloma.", "journal": "British journal of cancer", "date": "2014", "authors": "Gkotzamanidou M, Sfikakis PP, Kyrtopoulos SA, Bamia C, Dimopoulos MA, Souliotis VL", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25051404", "url": "https://glygen.org/publication/PubMed/25051404" } ] }, { "title": "Indoleamine 2,3-dioxygenase increases p53 levels in alloreactive human T cells, and both indoleamine 2,3-dioxygenase and p53 suppress glucose uptake, glycolysis and proliferation.", "journal": "International immunology", "date": "2014", "authors": "Eleftheriadis T, Pissas G, Antoniadi G, Spanoulis A, Liakopoulos V, Stefanidis I", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25064493", "url": "https://glygen.org/publication/PubMed/25064493" } ] }, { "title": "Bioinformatics study of cancer-related mutations within p53 phosphorylation site motifs.", "journal": "International journal of molecular sciences", "date": "2014", "authors": "Ji X, Huang Q, Yu L, Nussinov R, Ma B", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25075982", "url": "https://glygen.org/publication/PubMed/25075982" } ] }, { "title": "Profiling dose-dependent activation of p53-mediated signaling pathways by chemicals with distinct mechanisms of DNA damage.", "journal": "Toxicological sciences : an official journal of the Society of Toxicology", "date": "2014", "authors": "Clewell RA, Sun B, Adeleye Y, Carmichael P, Efremenko A, McMullen PD, Pendse S, Trask OJ, White A, Andersen ME", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25078064", "url": "https://glygen.org/publication/PubMed/25078064" } ] }, { "title": "Intramitochondrial recruitment of endolysosomes mediates Smac degradation and constitutes a novel intrinsic apoptosis antagonizing function of XIAP E3 ligase.", "journal": "Cell death and differentiation", "date": "2014", "authors": "Hamacher-Brady A, Choe SC, Krijnse-Locker J, Brady NR", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803204", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803204" } ], "reference": [ { "type": "PubMed", "id": "25080938", "url": "https://glygen.org/publication/PubMed/25080938" } ] }, { "title": "p53 is required for cisplatin-induced processing of the mitochondrial fusion protein L-Opa1 that is mediated by the mitochondrial metallopeptidase Oma1 in gynecologic cancers.", "journal": "The Journal of biological chemistry", "date": "2014", "authors": "Kong B, Wang Q, Fung E, Xue K, Tsang BK", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25112877", "url": "https://glygen.org/publication/PubMed/25112877" } ] }, { "title": "Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2014", "authors": "Impens F, Radoshevich L, Cossart P, Ribet D", "evidence": [ { "database": "Reactome", "id": "R-HSA-3232118", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3232118" } ], "reference": [ { "type": "PubMed", "id": "25114211", "url": "https://glygen.org/publication/PubMed/25114211" } ] }, { "title": "Upregulation of miR-760 and miR-186 is associated with replicative senescence in human lung fibroblast cells.", "journal": "Molecules and cells", "date": "2014", "authors": "Lee YH, Kim SY, Bae YS", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25139266", "url": "https://glygen.org/publication/PubMed/25139266" } ] }, { "title": "Failure of cell cleavage induces senescence in tetraploid primary cells.", "journal": "Molecular biology of the cell", "date": "2014", "authors": "Panopoulos A, Pacios-Bras C, Choi J, Yenjerla M, Sussman MA, Fotedar R, Margolis RL", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25143403", "url": "https://glygen.org/publication/PubMed/25143403" } ] }, { "title": "Cofactor Strap regulates oxidative phosphorylation and mitochondrial p53 activity through ATP synthase.", "journal": "Cell Death Differ.", "date": "2015", "authors": "Kessler B., La Thangue N.B., Coutts A.S., Maniam S., McGouran J., Stratford M.R.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "25168243", "url": "https://glygen.org/publication/PubMed/25168243" } ] }, { "title": "Deubiquitination and stabilization of IL-33 by USP21.", "journal": "International journal of clinical and experimental pathology", "date": "2014", "authors": "Tao L, Chen C, Song H, Piccioni M, Shi G, Li B", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "25197364", "url": "https://glygen.org/publication/PubMed/25197364" } ] }, { "title": "Activation of p53 by sodium selenite switched human leukemia NB4 cells from autophagy to apoptosis.", "journal": "Oncology research", "date": "2013", "authors": "Li Z, Shi K, Guan L, Jiang Q, Yang Y, Xu C", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25198662", "url": "https://glygen.org/publication/PubMed/25198662" } ] }, { "title": "Uncovering global SUMOylation signaling networks in a site-specific manner.", "journal": "Nature structural & molecular biology", "date": "2014", "authors": "Hendriks IA, D'Souza RC, Yang B, Verlaan-de Vries M, Mann M, Vertegaal AC", "evidence": [ { "database": "Reactome", "id": "R-HSA-3232118", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3232118" } ], "reference": [ { "type": "PubMed", "id": "25218447", "url": "https://glygen.org/publication/PubMed/25218447" } ] }, { "title": "PTEN deficiency and mutant p53 confer glucose-addiction to thyroid cancer cells: impact of glucose depletion on cell proliferation, cell survival, autophagy and cell migration.", "journal": "Genes & cancer", "date": "2014", "authors": "Morani F, Phadngam S, Follo C, Titone R, Thongrakard V, Galetto A, Alabiso O, Isidoro C", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25221641", "url": "https://glygen.org/publication/PubMed/25221641" } ] }, { "title": "Transfection of poly(I:C) can induce reactive oxygen species-triggered apoptosis and interferon-beta-mediated growth arrest in human renal cell carcinoma cells via innate adjuvant receptors and the 2-5A system.", "journal": "Molecular cancer", "date": "2014", "authors": "Harashima N, Minami T, Uemura H, Harada M", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25227113", "url": "https://glygen.org/publication/PubMed/25227113" } ] }, { "title": "Liver is the major source of elevated serum lipocalin-2 levels after bacterial infection or partial hepatectomy: a critical role for IL-6/STAT3.", "journal": "Hepatology (Baltimore, Md.)", "date": "2015", "authors": "Xu MJ, Feng D, Wu H, Wang H, Chan Y, Kolls J, Borregaard N, Porse B, Berger T, Mak TW, Cowland JB, Kong X, Gao B", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "25234944", "url": "https://glygen.org/publication/PubMed/25234944" } ] }, { "title": "Dimer monomer transition and dimer re-formation play important role for ATM cellular function during DNA repair.", "journal": "Biochemical and biophysical research communications", "date": "2014", "authors": "Du F, Zhang M, Li X, Yang C, Meng H, Wang D, Chang S, Xu Y, Price B, Sun Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-2559586", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2559586" } ], "reference": [ { "type": "PubMed", "id": "25240135", "url": "https://glygen.org/publication/PubMed/25240135" } ] }, { "title": "Guibitang, a traditional herbal medicine, induces apoptotic death in A431 cells by regulating the activities of mitogen-activated protein kinases.", "journal": "BMC complementary and alternative medicine", "date": "2014", "authors": "Yim NH, Kim A, Liang C, Cho WK, Ma JY", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25241226", "url": "https://glygen.org/publication/PubMed/25241226" } ] }, { "title": "Association of DCC, MLH1, GSTT1, GSTM1, and TP53 gene polymorphisms with colorectal cancer in Kazakhstan.", "journal": "Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine", "date": "2015", "authors": "Djansugurova L, Zhunussova G, Khussainova E, Iksan O, Afonin G, Kaidarova D, Parker MI", "evidence": [ { "database": "Entrez", "id": "7157", "url": "https://www.ncbi.nlm.nih.gov/gene/7157" } ], "reference": [ { "type": "PubMed", "id": "25249451", "url": "https://glygen.org/publication/PubMed/25249451" } ] }, { "title": "p53 as a retrovirus-induced oxidative stress modulator.", "journal": "The Journal of general virology", "date": "2015", "authors": "Kim SJ, Wong PKY", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25252686", "url": "https://glygen.org/publication/PubMed/25252686" } ] }, { "title": "High glucose dephosphorylates serine 46 and inhibits p53 apoptotic activity.", "journal": "Journal of experimental & clinical cancer research : CR", "date": "2014", "authors": "Garufi A, D'Orazi G", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25260780", "url": "https://glygen.org/publication/PubMed/25260780" } ] }, { "title": "The activation of G protein-coupled receptor 30 (GPR30) inhibits proliferation of estrogen receptor-negative breast cancer cells in vitro and in vivo.", "journal": "Cell death & disease", "date": "2014", "authors": "Wei W, Chen ZJ, Zhang KS, Yang XL, Wu YM, Chen XH, Huang HB, Liu HL, Cai SH, Du J, Wang HS", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25275589", "url": "https://glygen.org/publication/PubMed/25275589" } ] }, { "title": "Selenocysteine derivative overcomes TRAIL resistance in melanoma cells: evidence for ROS-dependent synergism and signaling crosstalk.", "journal": "Oncotarget", "date": "2014", "authors": "Cao W, Li X, Zheng S, Zheng W, Wong YS, Chen T", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25277183", "url": "https://glygen.org/publication/PubMed/25277183" } ] }, { "title": "TRIM8 anti-proliferative action against chemo-resistant renal cell carcinoma.", "journal": "Oncotarget", "date": "2014", "authors": "Caratozzolo MF, Valletti A, Gigante M, Aiello I, Mastropasqua F, Marzano F, Ditonno P, Carrieri G, Simonnet H, D'Erchia AM, Ranieri E, Pesole G, Sbisa E, Tullo A", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25277184", "url": "https://glygen.org/publication/PubMed/25277184" } ] }, { "title": "Small molecule restoration of wildtype structure and function of mutant p53 using a novel zinc-metallochaperone based mechanism.", "journal": "Oncotarget", "date": "2014", "authors": "Yu X, Blanden AR, Narayanan S, Jayakumar L, Lubin D, Augeri D, Kimball SD, Loh SN, Carpizo DR", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25294809", "url": "https://glygen.org/publication/PubMed/25294809" } ] }, { "title": "The histone H2A deubiquitinase USP16 interacts with HERC2 and fine-tunes cellular response to DNA damage.", "journal": "The Journal of biological chemistry", "date": "2014", "authors": "Zhang Z, Yang H, Wang H", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "25305019", "url": "https://glygen.org/publication/PubMed/25305019" } ] }, { "title": "Mutant p53 stimulates chemoresistance of pancreatic adenocarcinoma cells to gemcitabine.", "journal": "Biochimica et biophysica acta", "date": "2015", "authors": "Fiorini C, Cordani M, Padroni C, Blandino G, Di Agostino S, Donadelli M", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25311384", "url": "https://glygen.org/publication/PubMed/25311384" } ] }, { "title": "Phosphoproteomics reveals resveratrol-dependent inhibition of Akt/mTORC1/S6K1 signaling.", "journal": "Journal of proteome research", "date": "2014", "authors": "Alayev A, Doubleday PF, Berger SM, Ballif BA, Holz MK", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25311616", "url": "https://glygen.org/publication/PubMed/25311616" } ] }, { "title": "XAF1 directs apoptotic switch of p53 signaling through activation of HIPK2 and ZNF313.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2014", "authors": "Lee MG, Han J, Jeong SI, Her NG, Lee JH, Ha TK, Kang MJ, Ryu BK, Chi SG", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25313037", "url": "https://glygen.org/publication/PubMed/25313037" } ] }, { "title": "Effect of additive oxygen gas on cellular response of lung cancer cells induced by atmospheric pressure helium plasma jet.", "journal": "Scientific reports", "date": "2014", "authors": "Joh HM, Choi JY, Kim SJ, Chung TH, Kang TH", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25319447", "url": "https://glygen.org/publication/PubMed/25319447" } ] }, { "title": "Runt-related transcription factor 2 attenuates the transcriptional activity as well as DNA damage-mediated induction of pro-apoptotic TAp73 to regulate chemosensitivity.", "journal": "The FEBS journal", "date": "2015", "authors": "Ozaki T, Sugimoto H, Nakamura M, Hiraoka K, Yoda H, Sang M, Fujiwara K, Nagase H", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25331851", "url": "https://glygen.org/publication/PubMed/25331851" } ] }, { "title": "JNK-NQO1 axis drives TAp73-mediated tumor suppression upon oxidative and proteasomal stress.", "journal": "Cell death & disease", "date": "2014", "authors": "Kostecka A, Sznarkowska A, Meller K, Acedo P, Shi Y, Mohammad Sakil HA, Kawiak A, Lion M, Krolicka A, Wilhelm M, Inga A, Zawacka-Pankau J", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25341038", "url": "https://glygen.org/publication/PubMed/25341038" } ] }, { "title": "The molecular chaperone TRiC/CCT binds to the Trp-Asp 40 (WD40) repeat protein WDR68 and promotes its folding, protein kinase DYRK1A binding, and nuclear accumulation.", "journal": "The Journal of biological chemistry", "date": "2014", "authors": "Miyata Y, Shibata T, Aoshima M, Tsubata T, Nishida E", "evidence": [ { "database": "Reactome", "id": "R-HSA-390471", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-390471" } ], "reference": [ { "type": "PubMed", "id": "25342745", "url": "https://glygen.org/publication/PubMed/25342745" } ] }, { "title": "Co-expression of POU4F2/Brn-3b with p53 may be important for controlling expression of pro-apoptotic genes in cardiomyocytes following ischaemic/hypoxic insults.", "journal": "Cell death & disease", "date": "2014", "authors": "Budhram-Mahadeo V, Fujita R, Bitsi S, Sicard P, Heads R", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804759", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804759" } ], "reference": [ { "type": "PubMed", "id": "25356872", "url": "https://glygen.org/publication/PubMed/25356872" } ] }, { "title": "NPRL-Z-1, as a new topoisomerase II poison, induces cell apoptosis and ROS generation in human renal carcinoma cells.", "journal": "PloS one", "date": "2014", "authors": "Wu SY, Pan SL, Xiao ZY, Hsu JL, Chen MC, Lee KH, Teng CM", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25372714", "url": "https://glygen.org/publication/PubMed/25372714" } ] }, { "title": "Gastric Invasive Micropapillary Carcinoma with Intestinal Phenotypes Harboring a TP53 R175H Mutation.", "journal": "Case reports in oncology", "date": "2014", "authors": "Ikeda H, Kukitsu T, Johmen W, Nakamura H, Yamauchi N, Ishikawa K, Saikawa T, Noda S, Saitoh T, Ueno Y, Noda Y, Yamazaki S, Kuroda Y, Koshiko S, Sasagawa Y", "evidence": [ { "database": "Entrez", "id": "7157", "url": "https://www.ncbi.nlm.nih.gov/gene/7157" } ], "reference": [ { "type": "PubMed", "id": "25408652", "url": "https://glygen.org/publication/PubMed/25408652" } ] }, { "title": "Disruption of FAT10-MAD2 binding inhibits tumor progression.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2014", "authors": "Gao Y., Wang W., Chong S.S., Lim L., Song J., Chan C., Lee C.G., Qin H., Mah W.C., Theng S.S., Zhuo J.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "25422469", "url": "https://glygen.org/publication/PubMed/25422469" } ] }, { "title": "Expression, purification, and identification of associated proteins of the full-length hCDK12/CyclinK complex.", "journal": "The Journal of biological chemistry", "date": "2015", "authors": "Bartkowiak B, Greenleaf AL", "evidence": [ { "database": "Reactome", "id": "R-HSA-6796648", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6796648" } ], "reference": [ { "type": "PubMed", "id": "25429106", "url": "https://glygen.org/publication/PubMed/25429106" } ] }, { "title": "ROS inhibit autophagy by downregulating ULK1 mediated by the phosphorylation of p53 in selenite-treated NB4 cells.", "journal": "Cell death & disease", "date": "2014", "authors": "Ci Y, Shi K, An J, Yang Y, Hui K, Wu P, Shi L, Xu C", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25429619", "url": "https://glygen.org/publication/PubMed/25429619" } ] }, { "title": "Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1.", "journal": "Cell", "date": "2014", "authors": "Freund A, Zhong FL, Venteicher AS, Meng Z, Veenstra TD, Frydman J, Artandi SE", "evidence": [ { "database": "Reactome", "id": "R-HSA-390471", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-390471" } ], "reference": [ { "type": "PubMed", "id": "25467444", "url": "https://glygen.org/publication/PubMed/25467444" } ] }, { "title": "A novel manganese-dependent ATM-p53 signaling pathway is selectively impaired in patient-based neuroprogenitor and murine striatal models of Huntington's disease.", "journal": "Human molecular genetics", "date": "2015", "authors": "Tidball AM, Bryan MR, Uhouse MA, Kumar KK, Aboud AA, Feist JE, Ess KC, Neely MD, Aschner M, Bowman AB", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25489053", "url": "https://glygen.org/publication/PubMed/25489053" } ] }, { "title": "Knockdown of platinum-induced growth differentiation factor 15 abrogates p27-mediated tumor growth delay in the chemoresistant ovarian cancer model A2780cis.", "journal": "Cancer medicine", "date": "2015", "authors": "Meier JC, Haendler B, Seidel H, Groth P, Adams R, Ziegelbauer K, Kreft B, Beckmann G, Sommer A, Kopitz C", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25490861", "url": "https://glygen.org/publication/PubMed/25490861" } ] }, { "title": 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"reference": [ { "type": "PubMed", "id": "25578727", "url": "https://glygen.org/publication/PubMed/25578727" } ] }, { "title": "Peroxiredoxin 1 promotes tumorigenesis through regulating the activity of mTOR/p70S6K pathway in esophageal squamous cell carcinoma.", "journal": "Medical oncology (Northwood, London, England)", "date": "2015", "authors": "Gong F, Hou G, Liu H, Zhang M", "evidence": [ { "database": "Reactome", "id": "R-HSA-5628897", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5628897" } ], "reference": [ { "type": "PubMed", "id": "25579166", "url": "https://glygen.org/publication/PubMed/25579166" } ] }, { "title": "A spatiotemporal characterization of the effect of p53 phosphorylation on its interaction with MDM2.", "journal": "Cell cycle (Georgetown, Tex.)", "date": "2015", "authors": "ElSawy KM, Sim A, Lane DP, Verma CS, Caves LS", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], 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Physiol. Biochem.", "date": "2015", "authors": "Li X., Lu Z., Miao Z., Li W., Yang L., Zhou B., Huo X.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "25591766", "url": "https://glygen.org/publication/PubMed/25591766" } ] }, { "title": "Activation of p53 with ilimaquinone and ethylsmenoquinone, marine sponge metabolites, induces apoptosis and autophagy in colon cancer cells.", "journal": "Marine drugs", "date": "2015", "authors": "Lee HY, Chung KJ, Hwang IH, Gwak J, Park S, Ju BG, Yun E, Kim DE, Chung YH, Na M, Song GY, Oh S", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25603347", "url": "https://glygen.org/publication/PubMed/25603347" } ] }, { "title": "p53 activates G(1) checkpoint following DNA damage by doxorubicin during transient mitotic arrest.", "journal": 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T, Gilmartin AG, Ganji G, Pemmasani SK, Van Der Key H, Shohet JM, Donehower LA, Kumar R", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25658463", "url": "https://glygen.org/publication/PubMed/25658463" } ] }, { "title": "DNA damage-induced regulatory interplay between DAXX, p53, ATM kinase and Wip1 phosphatase.", "journal": "Cell cycle (Georgetown, Tex.)", "date": "2015", "authors": "Brazina J, Svadlenka J, Macurek L, Andera L, Hodny Z, Bartek J, Hanzlikova H", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25659035", "url": "https://glygen.org/publication/PubMed/25659035" } ] }, { "title": "IFI27, a novel epidermal growth factor-stabilized protein, is functionally involved in proliferation and cell cycling of human epidermal keratinocytes.", "journal": "Cell proliferation", "date": "2015", "authors": "Hsieh WL, Huang YH, Wang TM, Ming YC, Tsai CN, Pang JH", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25664647", "url": "https://glygen.org/publication/PubMed/25664647" } ] }, { "title": "Formononetin suppresses the proliferation of human non-small cell lung cancer through induction of cell cycle arrest and apoptosis.", "journal": "International journal of clinical and experimental pathology", "date": "2014", "authors": "Yang Y, Zhao Y, Ai X, Cheng B, Lu S", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25674209", "url": "https://glygen.org/publication/PubMed/25674209" } ] }, { "title": "EBNA3C regulates p53 through induction of Aurora kinase B.", "journal": 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growth pathways.", "journal": "Frontiers in microbiology", "date": "2015", "authors": "Alem F, Yao K, Lane D, Calvert V, Petricoin EF, Kramer L, Hale ML, Bavari S, Panchal RG, Hakami RM", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25762983", "url": "https://glygen.org/publication/PubMed/25762983" } ] }, { "title": "TP53 Y220C Is a Hotspot Mutation in Oropharyngeal Squamous Cell Carcinoma.", "journal": "Pathobiology : journal of immunopathology, molecular and cellular biology", "date": "2015", "authors": "van Kempen PM, Verdam FJ, de Poel E, Braunius WW, de Weger RA, van Es RJ, Grolman W, Willems SM", "evidence": [ { "database": "Entrez", "id": "7157", "url": "https://www.ncbi.nlm.nih.gov/gene/7157" } ], "reference": [ { "type": "PubMed", "id": "25765855", "url": "https://glygen.org/publication/PubMed/25765855" } ] }, { "title": "PML isoforms IV and V contribute to adenovirus-mediated oncogenic transformation by functionally inhibiting the tumor-suppressor p53.", "journal": "Oncogene", "date": "2016", "authors": "Dobner T., Hay R.T., Branton P.E., Groitl P., Schreiner S., Berscheminski J., Blanchette P., Wimmer P.", "evidence": [ { "database": "UniProtKB", "id": "P04637", "url": "https://www.uniprot.org/uniprot/P04637" } ], "reference": [ { "type": "PubMed", "id": "25772236", "url": "https://glygen.org/publication/PubMed/25772236" } ] }, { "title": "NORE1A is a Ras senescence effector that controls the apoptotic/senescent balance of p53 via HIPK2.", "journal": "The Journal of cell biology", "date": "2015", "authors": "Donninger H, Calvisi DF, Barnoud T, Clark J, Schmidt ML, Vos MD, Clark GJ", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25778922", "url": "https://glygen.org/publication/PubMed/25778922" } ] }, { "title": "p38/p53/miR-200a-3p feedback loop promotes oxidative stress-mediated liver cell death.", "journal": "Cell cycle (Georgetown, Tex.)", "date": "2015", "authors": "Xiao Y, Yan W, Lu L, Wang Y, Lu W, Cao Y, Cai W", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25789565", "url": "https://glygen.org/publication/PubMed/25789565" } ] }, { "title": "Ionizing radiation-induced adaptive response in fibroblasts under both monolayer and 3-dimensional conditions.", "journal": "PloS one", "date": "2015", "authors": "Zhao Y, Zhong R, Sun L, Jia J, Ma S, Liu X", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25807079", "url": "https://glygen.org/publication/PubMed/25807079" } ] }, { "title": "Ionizing radiation induces immediate protein acetylation changes in human cardiac microvascular endothelial cells.", "journal": "Journal of radiation research", "date": "2015", "authors": "Barjaktarovic Z, Kempf SJ, Sriharshan A, Merl-Pham J, Atkinson MJ, Tapio S", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25840449", "url": "https://glygen.org/publication/PubMed/25840449" } ] }, { "title": "Gene expression profile of human lung epithelial cells chronically exposed to single-walled carbon nanotubes.", "journal": "Nanoscale research letters", "date": "2015", "authors": "Chen D, Stueckle TA, Luanpitpong S, Rojanasakul Y, Lu Y, Wang L", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25852310", "url": "https://glygen.org/publication/PubMed/25852310" } ] }, { "title": "FBXW7-mutated colorectal cancer cells exhibit aberrant expression of phosphorylated-p53 at Serine-15.", "journal": "Oncotarget", "date": "2015", "authors": "Li N, Lorenzi F, Kalakouti E, Normatova M, Babaei-Jadidi R, Tomlinson I, Nateri AS", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25860929", "url": "https://glygen.org/publication/PubMed/25860929" } ] }, { "title": "Negative regulation of the p300-p53 interplay by DDX24.", "journal": "Oncogene", "date": "2016", "authors": "Shi D, Dai C, Qin J, Gu W", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25867071", "url": "https://glygen.org/publication/PubMed/25867071" } ] }, { "title": "Integrative genomic analysis reveals widespread enhancer regulation by p53 in response to DNA damage.", "journal": "Nucleic acids research", "date": "2015", "authors": "Younger ST, Kenzelmann-Broz D, Jung H, Attardi LD, Rinn JL", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25883152", "url": "https://glygen.org/publication/PubMed/25883152" } ] }, { "title": "A suppressive role of ionizing radiation-responsive miR-29c in the development of liver carcinoma via targeting WIP1.", "journal": "Oncotarget", "date": "2015", "authors": "Wang B, Li D, Sidler C, Rodriguez-Juarez R, Singh N, Heyns M, Ilnytskyy Y, Bronson RT, Kovalchuk O", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25888625", "url": "https://glygen.org/publication/PubMed/25888625" } ] }, { "title": "Cell cycle regulation of VCIP135 deubiquitinase activity and function in p97/p47-mediated Golgi reassembly.", "journal": "Molecular biology of the cell", "date": "2015", "authors": "Zhang X, Wang Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689896", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689896" } ], "reference": [ { "type": "PubMed", "id": "25904330", "url": "https://glygen.org/publication/PubMed/25904330" } ] }, { "title": "High levels of TopBP1 induce ATR-dependent shut-down of rRNA transcription and nucleolar segregation.", "journal": "Nucleic acids research", "date": "2015", "authors": "Sokka M, Rilla K, Miinalainen I, Pospiech H, Syvaoja JE", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25916852", "url": "https://glygen.org/publication/PubMed/25916852" } ] }, { "title": "PTEN over-expression by resveratrol in acute lymphoblastic leukemia cells along with suppression of AKT/PKB and ERK1/2 in genotoxic stress.", "journal": "Journal of natural medicines", "date": "2015", "authors": "Ghorbani A, Zand H, Jeddi-Tehrani M, Koohdani F, Shidfar F, Keshavarz SA", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25929783", "url": "https://glygen.org/publication/PubMed/25929783" } ] }, { "title": "The Tyrosine Kinase c-Abl Promotes Homeodomain-interacting Protein Kinase 2 (HIPK2) Accumulation and Activation in Response to DNA Damage.", "journal": "The Journal of biological chemistry", "date": "2015", "authors": "Reuven N, Adler J, Porat Z, Polonio-Vallon T, Hofmann TG, Shaul Y", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25944899", "url": "https://glygen.org/publication/PubMed/25944899" } ] }, { "title": "Different ATM Signaling in Response to Chromium(VI) Metabolism via Ascorbate and Nonascorbate Reduction: Implications for in Vitro Models and Toxicogenomics.", "journal": "Environmental health perspectives", "date": "2016", "authors": "Luczak MW, Green SE, Zhitkovich A", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25977998", "url": "https://glygen.org/publication/PubMed/25977998" } ] }, { "title": "Mitochondrial p53 phosphorylation induces Bak-mediated and caspase-independent cell death.", "journal": "Oncotarget", "date": "2015", "authors": "Wang J, Guo W, Zhou H, Luo N, Nie C, Zhao X, Yuan Z, Liu X, Wei Y", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25980443", "url": "https://glygen.org/publication/PubMed/25980443" } ] }, { "title": "Actinomycin D and nutlin-3a synergistically promote phosphorylation of p53 on serine 46 in cancer cell lines of different origin.", "journal": "Cellular signalling", "date": "2015", "authors": "Zajkowicz A, Gdowicz-Klosok A, Krzesniak M, Scieglinska D, Rusin M", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25989210", "url": "https://glygen.org/publication/PubMed/25989210" } ] }, { "title": "Evidence that selenium binding protein 1 is a tumor suppressor in prostate cancer.", "journal": "PloS one", "date": "2015", "authors": "Ansong E, Ying Q, Ekoue DN, Deaton R, Hall AR, Kajdacsy-Balla A, Yang W, Gann PH, Diamond AM", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "25993660", "url": "https://glygen.org/publication/PubMed/25993660" } ] }, { "title": "Spontaneous gammaH2AX Foci in Human Solid Tumor-Derived Cell Lines in Relation to p21WAF1 and WIP1 Expression.", "journal": "International journal of molecular sciences", "date": "2015", "authors": "Mirzayans R, Andrais B, Scott A, Wang YW, Weiss RH, Murray D", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "26006237", "url": "https://glygen.org/publication/PubMed/26006237" } ] }, { "title": "ROS-p53-cyclophilin-D signaling mediates salinomycin-induced glioma cell necrosis.", "journal": "Journal of experimental & clinical cancer research : CR", "date": "2015", "authors": "Qin LS, Jia PF, Zhang ZQ, Zhang SM", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "26024660", "url": "https://glygen.org/publication/PubMed/26024660" } ] }, { "title": "MDM2 and P53 polymorphisms contribute together to the risk and survival of prostate cancer.", "journal": "Oncotarget", "date": "2016", "authors": "Xue L, Han X, Liu R, Wang Z, Li H, Chen Q, Zhang P, Wang Z, Chong T", "evidence": [ { "database": "Entrez", "id": "7157", "url": "https://www.ncbi.nlm.nih.gov/gene/7157" } ], "reference": [ { "type": "PubMed", "id": "26025918", "url": "https://glygen.org/publication/PubMed/26025918" } ] }, { "title": "Real-time and simultaneous monitoring of the phosphorylation and enhanced interaction of p53 and XPC acidic domains with the TFIIH p62 subunit.", "journal": "Oncogenesis", "date": "2015", "authors": "Okuda M, Nishimura Y", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "26029824", "url": "https://glygen.org/publication/PubMed/26029824" } ] }, { "title": "Thyroid hormone and anti-apoptosis in tumor cells.", "journal": "Oncotarget", "date": "2015", "authors": "Lin HY, Glinsky GV, Mousa SA, Davis PJ", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "26041883", "url": "https://glygen.org/publication/PubMed/26041883" } ] }, { "title": "Antitumor Activity of a 5-Hydroxy-1H-Pyrrol-2-(5H)-One-Based Synthetic Small Molecule In Vitro and In Vivo.", "journal": "PloS one", "date": "2015", "authors": "Geng Y, Wang X, Yang L, Sun H, Wang Y, Zhao Y, She R, Wang MX, Wang DX, Tang J", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "26042776", "url": "https://glygen.org/publication/PubMed/26042776" } ] }, { "title": "Cytotoxic effects of replication-competent adenoviruses on human esophageal carcinoma are enhanced by forced p53 expression.", "journal": "BMC cancer", "date": "2015", "authors": "Yang S, Kawamura K, Okamoto S, Yamauchi S, Shingyoji M, Sekine I, Kobayashi H, Tada Y, Tatsumi K, Hiroshima K, Shimada H, Tagawa M", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "26059686", "url": "https://glygen.org/publication/PubMed/26059686" } ] }, { "title": "Purine analogue ENERGI-F706 induces apoptosis of 786-O renal carcinoma cells via 5'-adenosine monophosphate-activated protein kinase activation.", "journal": "Molecular medicine reports", "date": "2015", "authors": "Hsu CY, Lin CH, Lin JT, Cheng YF, Chen HM, Kao SH", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "26062651", "url": "https://glygen.org/publication/PubMed/26062651" } ] }, { "title": "Carbon-ion beams effectively induce growth inhibition and apoptosis in human neural stem cells compared with glioblastoma A172 cells.", "journal": "Journal of radiation research", "date": "2015", "authors": "Isono M, Yoshida Y, Takahashi A, Oike T, Shibata A, Kubota Y, Kanai T, Ohno T, Nakano T", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "26070322", "url": "https://glygen.org/publication/PubMed/26070322" } ] }, { "title": "Structural insight into the TRIAP1/PRELI-like domain family of mitochondrial phospholipid transfer complexes.", "journal": "EMBO reports", "date": "2015", "authors": "Miliara X, Garnett JA, Tatsuta T, Abid Ali F, Baldie H, Perez-Dorado I, Simpson P, Yague E, Langer T, Matthews S", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803204", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803204" } ], "reference": [ { "type": "PubMed", "id": "26071602", "url": "https://glygen.org/publication/PubMed/26071602" } ] }, { "title": "System-wide identification of wild-type SUMO-2 conjugation sites.", "journal": "Nature communications", "date": "2015", "authors": "Hendriks IA, D'Souza RC, Chang JG, Mann M, Vertegaal AC", "evidence": [ { "database": "Reactome", "id": "R-HSA-3232118", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3232118" } ], "reference": [ { "type": "PubMed", "id": "26073453", "url": "https://glygen.org/publication/PubMed/26073453" } ] }, { "title": "Human bronchial epithelial BEAS-2B cells, an appropriate in vitro model to study heavy metals induced carcinogenesis.", "journal": "Toxicology and applied pharmacology", "date": "2015", "authors": "Park YH, Kim D, Dai J, Zhang Z", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "26091798", "url": "https://glygen.org/publication/PubMed/26091798" } ] }, { "title": "Epigenetic inactivation of the candidate tumor suppressor gene ASC/TMS1 in human renal cell carcinoma and its role as a potential therapeutic target.", "journal": "Oncotarget", "date": "2015", "authors": "Liu Q, Jin J, Ying J, Cui Y, Sun M, Zhang L, Fan Y, Xu B, Zhang Q", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "26093088", "url": "https://glygen.org/publication/PubMed/26093088" } ] }, { "title": "XI-006 induces potent p53-independent apoptosis in Ewing sarcoma.", "journal": "Scientific reports", "date": "2015", "authors": "Pishas KI, Adwal A, Neuhaus SJ, Clayer MT, Farshid G, Staudacher AH, Callen DF", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "26095524", "url": "https://glygen.org/publication/PubMed/26095524" } ] }, { "title": "Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence.", "journal": "Nature communications", "date": "2015", "authors": "Sedic M, Skibinski A, Brown N, Gallardo M, Mulligan P, Martinez P, Keller PJ, Glover E, Richardson AL, Cowan J, Toland AE, Ravichandran K, Riethman H, Naber SP, Naar AM, Blasco MA, Hinds PW, Kuperwasser C", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "26106036", "url": "https://glygen.org/publication/PubMed/26106036" } ] }, { "title": "Pyruvate kinase isoenzyme M2 is a therapeutic target of gemcitabine-resistant pancreatic cancer cells.", "journal": "Experimental cell research", "date": "2015", "authors": "Kim DJ, Park YS, Kang MG, You YM, Jung Y, Koo H, Kim JA, Kim MJ, Hong SM, Lee KB, Jang JJ, Park KC, Yeom YI", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "26112218", "url": "https://glygen.org/publication/PubMed/26112218" } ] }, { "title": "HIPK2 restricts SIRT1 activity upon severe DNA damage by a phosphorylation-controlled mechanism.", "journal": "Cell death and differentiation", "date": "2016", "authors": "Conrad E, Polonio-Vallon T, Meister M, Matt S, Bitomsky N, Herbel C, Liebl M, Greiner V, Kriznik B, Schumacher S, Krieghoff-Henning E, Hofmann TG", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "26113041", "url": "https://glygen.org/publication/PubMed/26113041" } ] }, { "title": "Regulation of p53 during senescence in normal human keratinocytes.", "journal": "Aging cell", "date": "2015", "authors": "Kim RH, Kang MK, Kim T, Yang P, Bae S, Williams DW, Phung S, Shin KH, Hong C, Park NH", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "26138448", "url": "https://glygen.org/publication/PubMed/26138448" } ] }, { "title": "Aneuploidy generates proteotoxic stress and DNA damage concurrently with p53-mediated post-mitotic apoptosis in SAC-impaired cells.", "journal": "Nature communications", "date": "2015", "authors": "Ohashi A, Ohori M, Iwai K, Nakayama Y, Nambu T, Morishita D, Kawamoto T, Miyamoto M, Hirayama T, Okaniwa M, Banno H, Ishikawa T, Kandori H, Iwata K", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "26144554", "url": "https://glygen.org/publication/PubMed/26144554" } ] }, { "title": "CCAR2/DBC1 is required for Chk2-dependent KAP1 phosphorylation and repair of DNA damage.", "journal": "Oncotarget", "date": "2015", "authors": "Magni M, Ruscica V, Restelli M, Fontanella E, Buscemi G, Zannini L", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "26158765", "url": "https://glygen.org/publication/PubMed/26158765" } ] }, { "title": "Stress-mediated Sin3B activation leads to negative regulation of subset of p53 target genes.", "journal": "Bioscience reports", "date": "2015", "authors": "Kadamb R, Mittal S, Bansal N, Saluja D", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "26181367", "url": "https://glygen.org/publication/PubMed/26181367" } ] }, { "title": "Erdosteine protects HEI-OC1 auditory cells from cisplatin toxicity through suppression of inflammatory cytokines and induction of Nrf2 target proteins.", "journal": "Toxicology and applied pharmacology", "date": "2015", "authors": "Kim SJ, Park C, Lee JN, Lim H, Hong GY, Moon SK, Lim DJ, Choe SK, Park R", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "26193055", "url": "https://glygen.org/publication/PubMed/26193055" } ] }, { "title": "microRNA-21 Regulates Cell Proliferation and Migration and Cross Talk with PTEN and p53 in Bladder Cancer.", "journal": "DNA and cell biology", "date": "2015", "authors": "Lei M, Xie W, Sun E, Sun Y, Tian D, Liu C, Han R, Li N, Liu M, Han R, Liu L", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "26230405", "url": "https://glygen.org/publication/PubMed/26230405" } ] }, { "title": "The presence of wild type p53 in hematological cancers improves the efficacy of combinational therapy targeting metabolism.", "journal": "Oncotarget", "date": "2015", "authors": "Allende-Vega N, Krzywinska E, Orecchioni S, Lopez-Royuela N, Reggiani F, Talarico G, Rossi JF, Rossignol R, Hicheri Y, Cartron G, Bertolini F, Villalba M", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "26231043", "url": "https://glygen.org/publication/PubMed/26231043" } ] }, { "title": "USP18 negatively regulates NF-kappaB signaling by targeting TAK1 and NEMO for deubiquitination through distinct mechanisms.", "journal": "Scientific reports", "date": "2015", "authors": "Yang Z, Xian H, Hu J, Tian S, Qin Y, Wang RF, Cui J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9758274", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9758274" } ], "reference": [ { "type": "PubMed", "id": "26240016", "url": "https://glygen.org/publication/PubMed/26240016" } ] }, { "title": "Avian Reovirus Protein p17 Functions as a Nucleoporin Tpr Suppressor Leading to Activation of p53, p21 and PTEN and Inactivation of PI3K/AKT/mTOR and ERK Signaling Pathways.", "journal": "PloS one", "date": "2015", "authors": "Huang WR, Chiu HC, Liao TL, Chuang KP, Shih WL, Liu HJ", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "26244501", "url": "https://glygen.org/publication/PubMed/26244501" } ] }, { "title": "hSSB1 (NABP2/ OBFC2B) is required for the repair of 8-oxo-guanine by the hOGG1-mediated base excision repair pathway.", "journal": "Nucleic acids research", "date": "2015", "authors": "Paquet N, Adams MN, Leong V, Ashton NW, Touma C, Gamsjaeger R, Cubeddu L, Beard S, Burgess JT, Bolderson E, O'Byrne KJ, Richard DJ", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "26261212", "url": "https://glygen.org/publication/PubMed/26261212" } ] }, { "title": "Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis.", "journal": "Nature cell biology", "date": "2015", "authors": "Yuan L, Lv Y, Li H, Gao H, Song S, Zhang Y, Xing G, Kong X, Wang L, Li Y, Zhou T, Gao D, Xiao ZX, Yin Y, Wei W, He F, Zhang L", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689896", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689896" } ], "reference": [ { "type": "PubMed", "id": "26280536", "url": "https://glygen.org/publication/PubMed/26280536" } ] }, { "title": "The beneficial effect of Zinc(II) on low-dose chemotherapeutic sensitivity involves p53 activation in wild-type p53-carrying colorectal cancer cells.", "journal": "Journal of experimental & clinical cancer research : CR", "date": "2015", "authors": "Garufi A, Ubertini V, Mancini F, D'Orazi V, Baldari S, Moretti F, Bossi G, D'Orazi G", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "26297485", "url": "https://glygen.org/publication/PubMed/26297485" } ] }, { "title": "Toxoplasma gondii Rhoptry Protein ROP16 Mediates Partially SH-SY5Y Cells Apoptosis and Cell Cycle Arrest by Directing Ser15/37 Phosphorylation of p53.", "journal": "International journal of biological sciences", "date": "2015", "authors": "Chang S, Shan X, Li X, Fan W, Zhang SQ, Zhang J, Jiang N, Ma D, Mao Z", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "26327815", "url": "https://glygen.org/publication/PubMed/26327815" } ] }, { "title": "Subcellular Localization of Proteins Responding to Mitoxantrone-Induced DNA Damage in Leukaemic Cells.", "journal": "Folia biologica", "date": "2015", "authors": "Cmielova J, Lesna M, Rezacova M", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "26333122", "url": "https://glygen.org/publication/PubMed/26333122" } ] }, { "title": "Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death.", "journal": "Nature", "date": "2015", "authors": "Shi J, Zhao Y, Wang K, Shi X, Wang Y, Huang H, Zhuang Y, Cai T, Wang F, Shao F", "evidence": [ { "database": "Reactome", "id": "R-HSA-5620971", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5620971" } ], "reference": [ { "type": "PubMed", "id": "26375003", "url": "https://glygen.org/publication/PubMed/26375003" } ] }, { "title": "Involvement of p53 in insulin-like growth factor binding protein-3 regulation in the breast cancer cell response to DNA damage.", "journal": "Oncotarget", "date": "2015", "authors": "Marzec KA, Lin MZ, Martin JL, Baxter RC", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803211", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803211" } ], "reference": [ { "type": "PubMed", "id": "26378048", "url": "https://glygen.org/publication/PubMed/26378048" } ] }, { "title": "Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21(WAF1/CIP1) expression.", "journal": "Molecular brain", "date": "2015", "authors": "Ho DH, Kim H, Kim J, Sim H, Ahn H, Kim J, Seo H, Chung KC, Park BJ, Son I, Seol W", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "26384650", "url": "https://glygen.org/publication/PubMed/26384650" } ] }, { "title": "Mechanisms involved in p53 downregulation by leptin in trophoblastic cells.", "journal": "Placenta", "date": "2015", "authors": "Toro AR, Perez-Perez A, Corrales Gutierrez I, Sanchez-Margalet V, Varone CL", "evidence": [ { "database": "iPTMnet", "id": "P04637", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04637" } ], "reference": [ { "type": "PubMed", "id": "26386653", "url": "https://glygen.org/publication/PubMed/26386653" } ] } ] } }