{
    "uniprot_canonical_ac": "A0A8I5XWD7-1",
    "uniprot_ac": "A0A8I5XWD7",
    "uniprot_id": "A0A8I5XWD7_RAT",
    "mass": {
        "chemical_mass": 140017.0,
        "monoisotopic_mass": 140017.0
    },
    "refseq": {},
    "gene_names": [
        {
            "name": "Ppip5k2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A8I5XWD7",
            "id": "A0A8I5XWD7"
        },
        {
            "name": "LOC501194",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A8I5XWD7",
            "id": "A0A8I5XWD7"
        },
        {
            "name": "rCG_55411",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A8I5XWD7",
            "id": "A0A8I5XWD7"
        }
    ],
    "protein_names": [
        {
            "name": "Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A8I5XWD7#names_and_taxonomy",
            "id": "A0A8I5XWD7"
        },
        {
            "name": "2.7.4.24",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A8I5XWD7#names_and_taxonomy",
            "id": "A0A8I5XWD7"
        }
    ],
    "function": [
        {
            "annotation": "Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "F1LPI7",
                    "url": "https://www.uniprot.org/uniprot/F1LPI7#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "RU365032",
                    "url": "https://www.uniprot.org/uniprot/RU365032#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "A0A8I5XWD7",
                    "url": "https://www.uniprot.org/uniprot/A0A8I5XWD7#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "A0A096MKF1",
                    "url": "https://www.uniprot.org/uniprot/A0A096MKF1#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "A0A096MK18",
                    "url": "https://www.uniprot.org/uniprot/A0A096MK18#function"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:0050563",
            "recommended_name": {
                "id": "DOID:0050563",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0050563",
                "name": "nonsyndromic deafness",
                "description": "An auditory system disease that is associated with permanent hearing loss caused by damage to structures in the inner ear and/or the middle ear, which is not associated with other signs and symptoms."
            },
            "synonyms": [
                {
                    "id": "DOID:0050563",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0050563",
                    "name": "nonsyndromic hearing loss",
                    "description": ""
                },
                {
                    "id": "DOID:0050563",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0050563",
                    "name": "nonsyndromic hereditary hearing loss",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "0050563",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050563"
                }
            ]
        },
        {
            "disease_id": "DOID:0111638",
            "recommended_name": {
                "id": "DOID:0111638",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0111638",
                "name": "autosomal recessive nonsyndromic deafness 100",
                "description": "An autosomal recessive nonsyndromic deafness characterized by prelingual onset of profound sensorineural deafness without vestibular involvement that has_material_basis_in homozygous or compound heterozygous mutation in PPIP5K2 on chromosome 5q21.1."
            },
            "synonyms": [
                {
                    "id": "DOID:0111638",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111638",
                    "name": "DFNB100",
                    "description": ""
                },
                {
                    "id": "DOID:0111638",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111638",
                    "name": "autosomal recessive deafness 100",
                    "description": ""
                },
                {
                    "id": "MONDO:0032740",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0032740",
                    "name": "hearing loss, autosomal recessive 100",
                    "description": ""
                },
                {
                    "id": "MONDO:0032740",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0032740",
                    "name": "deafness, autosomal recessive 100",
                    "description": ""
                },
                {
                    "id": "MONDO:0032740",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0032740",
                    "name": "DFNB100",
                    "description": ""
                },
                {
                    "id": "MIM:618422",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/618422",
                    "name": "Deafness, autosomal recessive, 100",
                    "description": "Deafness, autosomal recessive, 100"
                }
            ],
            "evidence": [
                {
                    "id": "0111638",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0111638"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A8I5XWD7",
                    "url": "https://www.uniprot.org/uniprot/A0A8I5XWD7"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Ppip5k2",
            "url": "https://www.uniprot.org/uniprot/A0A8I5XWD7",
            "locus": {
                "chromosome": "9",
                "start_pos": 111220858,
                "end_pos": 111286185,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000011613",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000011613"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000011613",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000011613",
            "database": "Bgee"
        },
        {
            "id": "cd07061",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07061",
            "database": "CDD"
        },
        {
            "id": "IPR000560",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000560",
            "database": "InterPro"
        },
        {
            "id": "IPR029033",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR029033",
            "database": "InterPro"
        },
        {
            "id": "IPR033379",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR033379",
            "database": "InterPro"
        },
        {
            "id": "IPR037446",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR037446",
            "database": "InterPro"
        },
        {
            "id": "IPR040557",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR040557",
            "database": "InterPro"
        },
        {
            "id": "ECKGERI",
            "url": "https://omabrowser.org/oma/group/ECKGERI/",
            "database": "OMA"
        },
        {
            "id": "PTHR12750",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12750",
            "database": "PANTHER"
        },
        {
            "id": "PF00328",
            "url": "http://pfam.xfam.org/family/PF00328",
            "database": "Pfam"
        },
        {
            "id": "PF18086",
            "url": "http://pfam.xfam.org/family/PF18086",
            "database": "Pfam"
        },
        {
            "id": "1590765",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1590765",
            "database": "RGD"
        },
        {
            "id": "10276",
            "url": "https://www.rhea-db.org/rhea/10276",
            "database": "Rhea"
        },
        {
            "id": "37459",
            "url": "https://www.rhea-db.org/rhea/37459",
            "database": "Rhea"
        },
        {
            "id": "A0A096MK18",
            "url": "https://www.uniprot.org/uniprot/A0A096MK18",
            "database": "UniProtKB"
        },
        {
            "id": "A0A096MK18-1",
            "url": "https://www.uniprot.org/uniprot/A0A096MK18-1",
            "database": "UniProtKB"
        },
        {
            "id": "A0A096MKF1",
            "url": "https://www.uniprot.org/uniprot/A0A096MKF1",
            "database": "UniProtKB"
        },
        {
            "id": "A0A096MKF1-1",
            "url": "https://www.uniprot.org/uniprot/A0A096MKF1-1",
            "database": "UniProtKB"
        },
        {
            "id": "A0A8I5XWD7",
            "url": "https://www.uniprot.org/uniprot/A0A8I5XWD7",
            "database": "UniProtKB"
        },
        {
            "id": "A0A8I5XWD7-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I5XWD7-1",
            "database": "UniProtKB"
        },
        {
            "id": "F1LPI7",
            "url": "https://www.uniprot.org/uniprot/F1LPI7",
            "database": "UniProtKB"
        },
        {
            "id": "F1LPI7-1",
            "url": "https://www.uniprot.org/uniprot/F1LPI7-1",
            "database": "UniProtKB"
        }
    ],
    "sequence": {
        "sequence": "MSEAPRFFVGPEDAEINAGNYRRFFHHADEEEEEEEESPPERQIVVGICSMAKKSKSKPMKEILERISLFKYITVVVFEEDVILNEPVGDWPLCDCLISFHSKGFPLDKAVAYAKLRNPFVINDLNMQYHIQDRRDVYSILQAEGILLPRYAILNRDPNNPKECSLIEGEDHVEVNGEVFQKPFVEKPVSAEDHNVYIYYPTSAGGGSQRLFRKIGSRSSVYSPESSVRKTGSYIYEEFMPTDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEVRYPVILNAREKLIAWKVCLAFKQTVCGFDLLRANGQSYVCDVNGFSFVKNSMKYYDDCAKILGNIVMRELAPQFHIPWSIPLEAEDIPIVPTTSGTMMELRCVIAVIRHGDRTPKQKMKMEVRHQKFFDLFEKCDGYKSGKLKLKKPKQLQAILDIARQLLMELGQNNDSDIEENKSKLEQLKTVLEMYGHFSGINRKVQLTYLPHGCPKTSSEEEDNRREEPSLLLVLKWGGELTPAGRVQAEELGRAFRCMYPGGQGDYAGFPGCGLLRLHSTYRHDLKIYASDEGRVQMTAAAFAKGLLALEGELTPILVQMVKSANMNGLLDSDSDSLSSCQQRVKARLHEILQKDRDFTAEDYEKLTPSGSISVIKSMHLIKNPVKTCDKVYSLIQSLTSQIRHRMEDPKSADIQLYHSETLELMLRRWSKLEKDFKTKNGRYDISKIPDIYDCIKYDVQHNGSLKLENTMELYRLSKALADIVIPQEYGITKAEKLEIAKGYCTPLVRKIRSDLQRTQDDDTVNKLHPVYSRGVLSPERHVRTRLYFTSESHVHSLLSILRYGALCDESKDEQWKRAMDYLNVVNELNYMTQIVIMLYEDPNKDLSSEERFHVELHFSPGAKGCEEDKNLPSGYGYRPASRENEGRRSLRADDDEPHTSRRDEVDRAVMLFKPLVSEPIHIHRKSPLPRSRKMTSNEEETPLSVSSPEGTGTWLHYTSGVGTGRRRRRSGEQITSSPVSPKSLAFTSSIFGSWQQVVSENTNYLRAPRALVEQKQNPTVGSHCAGLFSTSVLGGSSSAPNLQDYARTHRKKLTSSGCIDDATRGSAVKRFSISFARHPTNGFELYSMVPSICPLETLHNALFLKQVDDFLASIASPSTEVLRKVPEMSSVASRSSPGIRRKISLNTYTPTKILPTPPAAVKSTKASSKAAAGGPSLAMASHTSSRKKSLSSKTEGHEPKKSTGKKR",
        "length": 1242,
        "header": "tr|A0A8I5XWD7-1|A0A8I5XWD7_RAT Isoform 1 of Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase  OS=Rattus norvegicus OX=10116 GN=Ppip5k2 PE=1 SV=1 CANONICAL=A0A8I5XWD7-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A096MK18-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I5XWD7#A0A096MK18-1",
            "sequence": {
                "sequence": "MSEAPRFFVGPEDAEINAGNYRRFFHHADEEEEEEEESPPERQIVVGICSMAKKSKSKPMKEILERISLFKYITVVVFEEDVILNEPVGDWPLCDCLISFHSKGFPLDKAVAYAKLRNPFVINDLNMQYHIQDRRDVYSILQAEGILLPRYAILNRDPNNPKECSLIEGEDHVEVNGEVFQKPFVEKPVSAEDHNVYIYYPTSAGGGSQRLFRKIGSRSSVYSPESSVRKTGSYIYEEFMPTDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEVRYPVILNAREKLIAWKVCLAFKQTVCGFDLLRANGQSYVCDVNGFSFVKNSMKYYDDCAKILGNIVMRELAPQFHIPWSIPLEAEDIPIVPTTSGTMMELRCVIAVIRHGDRTPKQKMKMEVRHQKFFDLFEKCDGYKSGKLKLKKPKQLQAILDIARQLLMELGQNNDSDIEENKSKLEQLKTVLEMYGHFSGINRKVQLTYLPHGCPKTSSEEEDNRREEPSLLLVLKWGGELTPAGRVQAEELGRAFRCMYPGGQGDYAGFPGCGLLRLHSTYRHDLKIYASDEGRVQMTAAAFAKGLLALEGELTPILVQMVKSANMNGLLDSDSDSLSSCQQRVKARLHEILQKDRDFTAEDYEKLTPSGSISVIKSMHLIKNPVKTCDKVYSLIQSLTSQIRHRMEDPKSADIQLYHSETLELMLRRWSKLEKDFKTKNGRYDISKIPDIYDCIKYDVQHNGSLKLENTMELYRLSKALADIVIPQEYGITKAEKLEIAKGYCTPLVRKIRSDLQRTQDDDTVNKLHPVYSRGVLSPERHVRTRLYFTSESHVHSLLSILRYGALCDESKDEQWKRAMDYLNVVNELNYMTQIVIMLYEDPNKDLSSEERFHVELHFSPGAKGCEEDKNLPSGYGYRPASRENEGRRSLRADDDEPHTSRRDEVDRAVMLFKPLVSEPIHIHRKSPLPRSRKMTSNEEETPLSVSSPEGTGTWLHYTSGVGTGRRRRRSGEQITSSPVSPKSLAFTSSIFGSWQQVVSENTNYLRAPRALVEQKQNPTVGFELYSMVPSICPLETLHNALFLKQVDDFLASIASPSTEVLRKVPEMSSVASRSSPGIRRKISLNTYTPTKILPTPPAAVKSTKASSKAAAGGPSLAMASHTSSRKKSLSSKTEGHEPKKSTGKKR",
                "length": 1181,
                "header": "tr|A0A096MK18-1|A0A8I5XWD7_RAT Computationally mapped isoform of Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase  OS=Rattus norvegicus OX=10116 GN=Ppip5k2 PE=1 SV=2 CANONICAL=A0A8I5XWD7-1"
            },
            "locus": {
                "chromosome": "9",
                "start_pos": 98379542,
                "end_pos": 98327449,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000076729.3",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000076729.3"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000068346.2",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000068346.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A096MKF1-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I5XWD7#A0A096MKF1-1",
            "sequence": {
                "sequence": "MSEAPRFFVGPEDAEINAGNYRRFFHHADEEEEEEEESPPERQIVVGICSMAKKSKSKPMKEILERISLFKYITVVVFEEDVILNEPVGDWPLCDCLISFHSKGFPLDKAVAYAKLRNPFVINDLNMQYHIQDRRDVYSILQAEGILLPRYAILNRDPNNPKECSLIEGEDHVEVNGEVFQKPFVEKPVSAEDHNVYIYYPTSAGGGSQRLFRKIGSRSSVYSPESSVRKTGSYIYEEFMPTDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEVRYPVILNAREKLIAWKVCLAFKQTVCGFDLLRANGQSYVCDVNGFSFVKNSMKYYDDCAKILGNIVMRELAPQFHIPWSIPLEAEDIPIVPTTSGTMMELRCVIAVIRHGDRTPKQKMKMEVRHQKFFDLFEKCDGYKSGKLKLKKPKQLQAILDIARQLLMELGQNNDSDIEENKSKLEQLKTVLEMYGHFSGINRKVQLTYLPHGCPKTSSEEEDNRREEPSLLLVLKWGGELTPAGRVQAEELGRAFRCMYPGGQGDYAGFPGCGLLRLHSTYRHDLKIYASDEGRVQMTAAAFAKGLLALEGELTPILVQMVKSANMNGLLDSDSDSLSSCQQRVKARLHEILQKDRDFTAEDYEKLTPSGSISVIKSMHLIKNPVKTCDKVYSLIQSLTSQIRHRMEDPKSADIQLYHSETLELMLRRWSKLEKDFKTKNGRYDISKIPDIYDCIKYDVQHNGSLKLENTMELYRLSKALADIVIPQEYGITKAEKLEIAKGYCTPLVRKIRSDLQRTQDDDTVNKLHPVYSRGVLSPERHVRTRLYFTSESHVHSLLSILRYGALCDESKDEQWKRAMDYLNVVNELNYMTQIVIMLYEDPNKDLSSEERFHVELHFSPGAKGCEEDKNLPSGYGYRPASRENEGRRSLRADDDEPHTSRRDEVDRAVMLFKPLVSEPIHIHRKSPLPRSRKMTSNEVVSENTNYLRAPRALVEQKQNPTVGFELYSMVPSICPLETLHNALFLKQVDDFLASIASPSTEVLRKVPEMSSVASRSSPGIRRKISLNTYTPTKILPTPPAAVKSTKASSKADFGLENKRKTADIQE",
                "length": 1101,
                "header": "tr|A0A096MKF1-1|A0A8I5XWD7_RAT Computationally mapped isoform of Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase  OS=Rattus norvegicus OX=10116 GN=Ppip5k2 PE=1 SV=2 CANONICAL=A0A8I5XWD7-1"
            },
            "locus": {
                "chromosome": "9",
                "start_pos": 98390673,
                "end_pos": 98327449,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000076669.3",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000076669.3"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000068491.2",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000068491.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A8I5XWD7-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I5XWD7#A0A8I5XWD7-1",
            "sequence": {
                "sequence": "MSEAPRFFVGPEDAEINAGNYRRFFHHADEEEEEEEESPPERQIVVGICSMAKKSKSKPMKEILERISLFKYITVVVFEEDVILNEPVGDWPLCDCLISFHSKGFPLDKAVAYAKLRNPFVINDLNMQYHIQDRRDVYSILQAEGILLPRYAILNRDPNNPKECSLIEGEDHVEVNGEVFQKPFVEKPVSAEDHNVYIYYPTSAGGGSQRLFRKIGSRSSVYSPESSVRKTGSYIYEEFMPTDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEVRYPVILNAREKLIAWKVCLAFKQTVCGFDLLRANGQSYVCDVNGFSFVKNSMKYYDDCAKILGNIVMRELAPQFHIPWSIPLEAEDIPIVPTTSGTMMELRCVIAVIRHGDRTPKQKMKMEVRHQKFFDLFEKCDGYKSGKLKLKKPKQLQAILDIARQLLMELGQNNDSDIEENKSKLEQLKTVLEMYGHFSGINRKVQLTYLPHGCPKTSSEEEDNRREEPSLLLVLKWGGELTPAGRVQAEELGRAFRCMYPGGQGDYAGFPGCGLLRLHSTYRHDLKIYASDEGRVQMTAAAFAKGLLALEGELTPILVQMVKSANMNGLLDSDSDSLSSCQQRVKARLHEILQKDRDFTAEDYEKLTPSGSISVIKSMHLIKNPVKTCDKVYSLIQSLTSQIRHRMEDPKSADIQLYHSETLELMLRRWSKLEKDFKTKNGRYDISKIPDIYDCIKYDVQHNGSLKLENTMELYRLSKALADIVIPQEYGITKAEKLEIAKGYCTPLVRKIRSDLQRTQDDDTVNKLHPVYSRGVLSPERHVRTRLYFTSESHVHSLLSILRYGALCDESKDEQWKRAMDYLNVVNELNYMTQIVIMLYEDPNKDLSSEERFHVELHFSPGAKGCEEDKNLPSGYGYRPASRENEGRRSLRADDDEPHTSRRDEVDRAVMLFKPLVSEPIHIHRKSPLPRSRKMTSNEEETPLSVSSPEGTGTWLHYTSGVGTGRRRRRSGEQITSSPVSPKSLAFTSSIFGSWQQVVSENTNYLRAPRALVEQKQNPTVGSHCAGLFSTSVLGGSSSAPNLQDYARTHRKKLTSSGCIDDATRGSAVKRFSISFARHPTNGFELYSMVPSICPLETLHNALFLKQVDDFLASIASPSTEVLRKVPEMSSVASRSSPGIRRKISLNTYTPTKILPTPPAAVKSTKASSKAAAGGPSLAMASHTSSRKKSLSSKTEGHEPKKSTGKKR",
                "length": 1242,
                "header": "tr|A0A8I5XWD7-1|A0A8I5XWD7_RAT Isoform 1 of Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase  OS=Rattus norvegicus OX=10116 GN=Ppip5k2 PE=1 SV=1 CANONICAL=A0A8I5XWD7-1"
            },
            "locus": {
                "chromosome": "9",
                "start_pos": 98379542,
                "end_pos": 98327449,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000095195.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000095195.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000077673.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000077673.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "F1LPI7-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I5XWD7#F1LPI7-1",
            "sequence": {
                "sequence": "MSEAPRFFVGPEDAEINAGNYRRFFHHADEEEEEEEESPPERQIVVGICSMAKKSKSKPMKEILERISLFKYITVVVFEEDVILNEPVGDWPLCDCLISFHSKGFPLDKAVAYAKLRNPFVINDLNMQYHIQDRRDVYSILQAEGILLPRYAILNRDPNNPKECSLIEGEDHVEVNGEVFQKPFVEKPVSAEDHNVYIYYPTSAGGGSQRLFRKIGSRSSVYSPESSVRKTGSYIYEEFMPTDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEVRYPVILNAREKLIAWKVCLAFKQTVCGFDLLRANGQSYVCDVNGFSFVKNSMKYYDDCAKILGNIVMRELAPQFHIPWSIPLEAEDIPIVPTTSGTMMELRCVIAVIRHGDRTPKQKMKMEVRHQKFFDLFEKCDGYKSGKLKLKKPKQLQAILDIARQLLMELGQNNDSDIEENKSKLEQLKTVLEMYGHFSGINRKVQLTYLPHGCPKTSSEEEDNRREEPSLLLVLKWGGELTPAGRVQAEELGRAFRCMYPGGQGDYAGFPGCGLLRLHSTYRHDLKIYASDEGRVQMTAAAFAKGLLALEGELTPILVQMVKSANMNGLLDSDSDSLSSCQQRVKARLHEILQKDRDFTAEDYEKLTPSGSISVIKSMHLIKNPVKTCDKVYSLIQSLTSQIRHRMEDPKSADIQLYHSETLELMLRRWSKLEKDFKTKNGRYDISKIPDIYDCIKYDVQHNGSLKLENTMELYRLSKALADIVIPQEYGITKAEKLEIAKGYCTPLVRKIRSDLQRTQDDDTVNKLHPVYSRGVLSPERHVRTRLYFTSESHVHSLLSILRYGALCDESKDEQWKRAMDYLNVVNELNYMTQIVIMLYEDPNKDLSSEERFHVELHFSPGAKGCEEDKNLPSGYGYRPASRENEGRRSLRADDDEPHTSRRDEVDRAVMLFKPLVSEPIHIHRKSPLPRSRKMTSNEVVSENTNYLRAPRALVEQKQNPTVGSHCAGLFSTSVLGGSSSAPNLQDYARTHRKKLTSSGCIDDATRGSAVKRFSISFARHPTNGFELYSMVPSICPLETLHNALFLKQVDDFLASIASPSTEVLRKVPEMSSVASRSSPGIRRKISLNTYTPTKILPTPPAAVKSTKASSKAAAGGPSLAMASHTSSRKKSLSSKTEGHEPKKSTGKKR",
                "length": 1184,
                "header": "tr|F1LPI7-1|A0A8I5XWD7_RAT Computationally mapped isoform of Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase  OS=Rattus norvegicus OX=10116 GN=Ppip5k2 PE=1 SV=4 CANONICAL=A0A8I5XWD7-1"
            },
            "locus": {
                "chromosome": "9",
                "start_pos": 98379542,
                "end_pos": 98327449,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000056439.5",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000056439.5"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000053278.5",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000053278.5"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [
        "enzyme"
    ],
    "publication": [
        {
            "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.",
            "journal": "Nat. Commun.",
            "date": "2012",
            "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A096MK18",
                    "url": "https://www.uniprot.org/uniprot/A0A096MK18"
                },
                {
                    "database": "UniProtKB",
                    "id": "A0A096MKF1",
                    "url": "https://www.uniprot.org/uniprot/A0A096MKF1"
                },
                {
                    "database": "UniProtKB",
                    "id": "F1LPI7",
                    "url": "https://www.uniprot.org/uniprot/F1LPI7"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "22673903",
                    "url": "https://glygen.org/publication/PubMed/22673903"
                }
            ]
        }
    ],
    "pathway": [],
    "orthologs": [],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 3,
                "go_terms": [
                    {
                        "name": "inositol metabolic process",
                        "id": "GO:0006020",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006020",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A8I5XWD7",
                                "url": "https://www.uniprot.org/uniprot/A0A8I5XWD7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "phosphorylation",
                        "id": "GO:0016310",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016310",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A8I5XWD7",
                                "url": "https://www.uniprot.org/uniprot/A0A8I5XWD7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "inositol phosphate biosynthetic process",
                        "id": "GO:0032958",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032958",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A8I5XWD7",
                                "url": "https://www.uniprot.org/uniprot/A0A8I5XWD7"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 8,
                "go_terms": [
                    {
                        "name": "inositol-1,3,4,5,6-pentakisphosphate kinase activity",
                        "id": "GO:0000827",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000827",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A8I5XWD7",
                                "url": "https://www.uniprot.org/uniprot/A0A8I5XWD7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "inositol hexakisphosphate kinase activity",
                        "id": "GO:0000828",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000828",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A8I5XWD7",
                                "url": "https://www.uniprot.org/uniprot/A0A8I5XWD7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "inositol heptakisphosphate kinase activity",
                        "id": "GO:0000829",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000829",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A8I5XWD7",
                                "url": "https://www.uniprot.org/uniprot/A0A8I5XWD7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "inositol hexakisphosphate 5-kinase activity",
                        "id": "GO:0000832",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000832",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A8I5XWD7",
                                "url": "https://www.uniprot.org/uniprot/A0A8I5XWD7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "inositol hexakisphosphate 1-kinase activity",
                        "id": "GO:0052723",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052723",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A8I5XWD7",
                                "url": "https://www.uniprot.org/uniprot/A0A8I5XWD7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "inositol hexakisphosphate 3-kinase activity",
                        "id": "GO:0052724",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052724",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A8I5XWD7",
                                "url": "https://www.uniprot.org/uniprot/A0A8I5XWD7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "diphosphoinositol-pentakisphosphate kinase activity",
                        "id": "GO:0033857",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033857",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A8I5XWD7",
                                "url": "https://www.uniprot.org/uniprot/A0A8I5XWD7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ATP binding",
                        "id": "GO:0005524",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A8I5XWD7",
                                "url": "https://www.uniprot.org/uniprot/A0A8I5XWD7"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 1,
                "go_terms": [
                    {
                        "name": "cytosol",
                        "id": "GO:0005829",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A8I5XWD7",
                                "url": "https://www.uniprot.org/uniprot/A0A8I5XWD7"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 448,
            "end_pos": 450,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 455,
            "end_pos": 457,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 737,
            "end_pos": 739,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [
        {
            "id": "10276",
            "name": "",
            "equation": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP",
            "summary": "",
            "cellular_location": "",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P0C644-1",
                "A0A8I5XWD7-1",
                "Q6PFW1-1",
                "O43314-1",
                "A2ARP1-1",
                "Q6ZQB6-1",
                "Q9VR59-1"
            ],
            "evidence": [
                {
                    "id": "10276",
                    "database": "Rhea",
                    "url": "https://www.rhea-db.org/rhea/10276"
                }
            ]
        },
        {
            "id": "37459",
            "name": "",
            "equation": "1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP",
            "summary": "",
            "cellular_location": "",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P0C644-1",
                "A0A8I5XWD7-1",
                "Q6PFW1-1",
                "O43314-1",
                "A2ARP1-1",
                "Q6ZQB6-1",
                "Q9VR59-1"
            ],
            "evidence": [
                {
                    "id": "37459",
                    "database": "Rhea",
                    "url": "https://www.rhea-db.org/rhea/37459"
                }
            ]
        }
    ],
    "reaction_participants": [],
    "reaction_enzymes": [
        {
            "uniprot_ac": "A0A8I5XWD7",
            "gene_name": "Ppip5k2",
            "activity": [
                {
                    "ec_number": "2.7.4.24",
                    "activity": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP.",
                    "evidence": [
                        {
                            "id": "A0A8I5XWD7",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A0A8I5XWD7"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.4.24",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "A0A8I5XWD7",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A0A8I5XWD7"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "A2ARP1",
            "gene_name": "Ppip5k1",
            "activity": [
                {
                    "ec_number": "2.7.4.24",
                    "activity": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP.",
                    "evidence": [
                        {
                            "id": "A2ARP1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A2ARP1"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.4.24",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "A2ARP1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/A2ARP1"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "O43314",
            "gene_name": "PPIP5K2",
            "activity": [
                {
                    "ec_number": "2.7.4.24",
                    "activity": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP.",
                    "evidence": [
                        {
                            "id": "O43314",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O43314"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.4.24",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "O43314",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O43314"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P0C644",
            "gene_name": "Ppip5k1",
            "activity": [
                {
                    "ec_number": "2.7.4.24",
                    "activity": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP.",
                    "evidence": [
                        {
                            "id": "P0C644",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P0C644"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.4.24",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P0C644",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P0C644"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q6PFW1",
            "gene_name": "PPIP5K1",
            "activity": [
                {
                    "ec_number": "2.7.4.24",
                    "activity": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP.",
                    "evidence": [
                        {
                            "id": "Q6PFW1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6PFW1"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.4.24",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q6PFW1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6PFW1"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q6ZQB6",
            "gene_name": "Ppip5k2",
            "activity": [
                {
                    "ec_number": "2.7.4.24",
                    "activity": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP.",
                    "evidence": [
                        {
                            "id": "Q6ZQB6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6ZQB6"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.4.24",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q6ZQB6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6ZQB6"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q9VR59",
            "gene_name": "l(1)G0196",
            "activity": [
                {
                    "ec_number": "2.7.4.24",
                    "activity": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP.",
                    "evidence": [
                        {
                            "id": "Q9VR59",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9VR59"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.4.24",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q9VR59",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q9VR59"
                        }
                    ]
                }
            ]
        }
    ],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        }
    ]
}