{ "uniprot_canonical_ac": "A0A5F8MPP0-1", "uniprot_ac": "A0A5F8MPP0", "uniprot_id": "A0A5F8MPP0_MOUSE", "mass": { "chemical_mass": 164121.0, "monoisotopic_mass": 164121.0 }, "refseq": { "ac": "NP_001028425", "name": "pleckstrin homology domain-containing family G member 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028425" }, "gene_names": [ { "name": "Plekhg1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A5F8MPP0", "id": "A0A5F8MPP0" }, { "name": "D10Ertd733e; Gm521; mKIAA1209", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028425", "id": "NP_001028425" }, { "name": "Plekhg1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028425", "id": "NP_001028425" } ], "protein_names": [ { "name": "Pleckstrin homology domain-containing, family G (with RhoGef domain) member 1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A5F8MPP0#names_and_taxonomy", "id": "A0A5F8MPP0" }, { "name": "pleckstrin homology domain-containing family G member 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028425", "id": "NP_001028425" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A0A5F8MPP0", "url": "https://www.uniprot.org/uniprot/A0A5F8MPP0" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Plekhg1", "url": "https://www.uniprot.org/uniprot/A0A5F8MPP0", "locus": { "chromosome": "10", "start_pos": 3740364, "end_pos": 3967303, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000040624", "url": "https://www.ensembl.org/id/ENSMUSG00000040624" } ] } } ], "crossref": [ { "id": "ENSMUSG00000040624", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000040624", "database": "Bgee" }, { "id": "cd00160", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00160", "database": "CDD" }, { "id": "cd13243", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13243", "database": "CDD" }, { "id": "213783", "url": "https://www.ncbi.nlm.nih.gov/gene/213783", "database": "GeneID" }, { "id": "IPR000219", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000219", "database": "InterPro" }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro" }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro" }, { "id": "IPR035899", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035899", "database": "InterPro" }, { "id": "IPR043324", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043324", "database": "InterPro" }, { "id": "mmu:213783", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:213783", "database": "KEGG Pathway" }, { "id": "2676551", "url": "http://www.informatics.jax.org/marker/MGI:2676551", "database": "MGI" }, { "id": "WHSTYSN", "url": "https://omabrowser.org/oma/group/WHSTYSN/", "database": "OMA" }, { "id": "147068at2759", "url": "http://www.orthodb.org/?query=147068at2759", "database": "OrthoDB" }, { "id": "PF00621", "url": "http://pfam.xfam.org/family/PF00621", "database": "Pfam" }, { "id": "R-MMU-9013148", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9013148", "database": "Reactome" }, { "id": "R-MMU-9013149", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9013149", "database": "Reactome" }, { "id": "NP_001028425", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028425", "database": "RefSeq" }, { "id": "A0A5F8MPP0", "url": "https://www.uniprot.org/uniprot/A0A5F8MPP0", "database": "UniProtKB" }, { "id": "A0A5F8MPP0-1", "url": "https://www.uniprot.org/uniprot/A0A5F8MPP0-1", "database": "UniProtKB" }, { "id": "F6S200", "url": "https://www.uniprot.org/uniprot/F6S200", "database": "UniProtKB" }, { "id": "F6S200-1", "url": "https://www.uniprot.org/uniprot/F6S200-1", "database": "UniProtKB" }, { "id": "F7C583", "url": "https://www.uniprot.org/uniprot/F7C583", "database": "UniProtKB" }, { "id": "F7C583-1", "url": "https://www.uniprot.org/uniprot/F7C583-1", "database": "UniProtKB" }, { "id": "F7CES2", "url": "https://www.uniprot.org/uniprot/F7CES2", "database": "UniProtKB" }, { "id": "F7CES2-1", "url": "https://www.uniprot.org/uniprot/F7CES2-1", "database": "UniProtKB" }, { "id": "Q3UX37", "url": "https://www.uniprot.org/uniprot/Q3UX37", "database": "UniProtKB" }, { "id": "Q3UX37-1", "url": "https://www.uniprot.org/uniprot/Q3UX37-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MLSTTMVGTLVRGWRNRSSPRRAELKPAAPQRQGGIRIHETDGHRHLQLDVPSAVSLVPDPRTTAEPSESPEPKTMELSDSDRPISFGSTSSSASSRDSHGSFGSRMTLVSNSHLGLFHQDKEAGAIKLELVPARPFSSSELQRDKPAGPQNMNGVSEKQPRTPWRMDTSGTPQTTADSATSPKLLYVDRVVQEILETERTYVQDLKSIVEGYLECIRDQTKLPLVTEDRAALFGNIQDIYHFNSELLQDLENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILTKFFRERQETLRHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKATEGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQSLLTNWEGPDLTSYGELVLEGTFRIQKAKKERTLFLLDQLLLITKKRDDTFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQHTVQAKSQQDKRLWVLHLKRLILENHAAAAKIPAKAKQAILEMDAIHYPGFCYSPEGEMKTPCGSAPHRLRRKSEPSSRSHKVLKTSETSQDIQKVSREESPSQLTSAVPAQRNCQPGSAAVINMLRGGGGVRSPWTDHHIRQRTDHHIRQPLFPSRRSPQENEDDDDDYQMFVPSFSSSDLNSTRLCEENASSRPCSWHLGLIEPTEISSSGHRIVRRASSAGESNACPPEVRIRDCDDSQYCPGRQLQNSPRPGGERGMTPYGSSVELTIDDIDHVYDNISFEDLKLMVAKRDETECSFSKPSRDSVRPKSTPELAFSKRQVSHSTSSLHSRKEAGLGGQEASTQSVHEHQEVEENIYDTIGLPDPPSMNLNHSSLHQPKRSTFLGLEADFACCDSLRPFVSQDSLQFSEDDISYHQGPSDTEYLSLLYDSPRCNLPIADKALSDKLSEEVDEIWNDLENYIKKNEDKSRDRLLAAFPVSKDDAPERLYVDSTHELGRDTGHATSMLALPTSQTFLLPGKSRVVRASRANCSLDNDIISTEGSFLSLNQLSLASDGPPVDNPYDLANCSLPQTDPENPDPGMEVTDKTKSRVFMMARQYSQKIKKVNQILKVKSPELEQPPSSQHRPSHKDLVAILEEKRQGGPAIGARIAEYSQLYDQIVFRETPLKAQKDGWASPQGPTLHRPVSPPQAQGAGEDWLWHSPYSNGELADFSPQTEQDSKSKYPITLESTTKIRPRQLSGACSVPSLQVSDPLLGSVQQRCSVVVSQPHKENSGQSPLYNSLGRKAISAKPQPYSRPQSSSSILINKSLDSINYPSETETKQLLSSQKSPRGASQQDLPSGLANSCQQDRGKRSDLTLQDSQKVLVVNRNLPLSAQIATQNYFCNFKDPEGDEDDYVEIKSEEDEVRLDLSPRRGRKSDPQTPDPDCSDSICSHSTPYSLKEPVSGRLGLPPYLTACKDSDKLNDYLWRGPSPNQQNIVQSLREKFQCLSSSSFA", "length": 1465, "header": "tr|A0A5F8MPP0-1|A0A5F8MPP0_MOUSE Isoform 1 of Pleckstrin homology domain-containing, family G (with RhoGef domain) member 1 OS=Mus musculus OX=10090 GN=Plekhg1 PE=1 SV=1 CANONICAL=A0A5F8MPP0-1" }, "isoforms": [ { "isoform_ac": "A0A5F8MPP0-1", "url": "https://www.uniprot.org/uniprot/A0A5F8MPP0#A0A5F8MPP0-1", "sequence": { "sequence": "MLSTTMVGTLVRGWRNRSSPRRAELKPAAPQRQGGIRIHETDGHRHLQLDVPSAVSLVPDPRTTAEPSESPEPKTMELSDSDRPISFGSTSSSASSRDSHGSFGSRMTLVSNSHLGLFHQDKEAGAIKLELVPARPFSSSELQRDKPAGPQNMNGVSEKQPRTPWRMDTSGTPQTTADSATSPKLLYVDRVVQEILETERTYVQDLKSIVEGYLECIRDQTKLPLVTEDRAALFGNIQDIYHFNSELLQDLENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILTKFFRERQETLRHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKATEGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQSLLTNWEGPDLTSYGELVLEGTFRIQKAKKERTLFLLDQLLLITKKRDDTFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQHTVQAKSQQDKRLWVLHLKRLILENHAAAAKIPAKAKQAILEMDAIHYPGFCYSPEGEMKTPCGSAPHRLRRKSEPSSRSHKVLKTSETSQDIQKVSREESPSQLTSAVPAQRNCQPGSAAVINMLRGGGGVRSPWTDHHIRQRTDHHIRQPLFPSRRSPQENEDDDDDYQMFVPSFSSSDLNSTRLCEENASSRPCSWHLGLIEPTEISSSGHRIVRRASSAGESNACPPEVRIRDCDDSQYCPGRQLQNSPRPGGERGMTPYGSSVELTIDDIDHVYDNISFEDLKLMVAKRDETECSFSKPSRDSVRPKSTPELAFSKRQVSHSTSSLHSRKEAGLGGQEASTQSVHEHQEVEENIYDTIGLPDPPSMNLNHSSLHQPKRSTFLGLEADFACCDSLRPFVSQDSLQFSEDDISYHQGPSDTEYLSLLYDSPRCNLPIADKALSDKLSEEVDEIWNDLENYIKKNEDKSRDRLLAAFPVSKDDAPERLYVDSTHELGRDTGHATSMLALPTSQTFLLPGKSRVVRASRANCSLDNDIISTEGSFLSLNQLSLASDGPPVDNPYDLANCSLPQTDPENPDPGMEVTDKTKSRVFMMARQYSQKIKKVNQILKVKSPELEQPPSSQHRPSHKDLVAILEEKRQGGPAIGARIAEYSQLYDQIVFRETPLKAQKDGWASPQGPTLHRPVSPPQAQGAGEDWLWHSPYSNGELADFSPQTEQDSKSKYPITLESTTKIRPRQLSGACSVPSLQVSDPLLGSVQQRCSVVVSQPHKENSGQSPLYNSLGRKAISAKPQPYSRPQSSSSILINKSLDSINYPSETETKQLLSSQKSPRGASQQDLPSGLANSCQQDRGKRSDLTLQDSQKVLVVNRNLPLSAQIATQNYFCNFKDPEGDEDDYVEIKSEEDEVRLDLSPRRGRKSDPQTPDPDCSDSICSHSTPYSLKEPVSGRLGLPPYLTACKDSDKLNDYLWRGPSPNQQNIVQSLREKFQCLSSSSFA", "length": 1465, "header": "tr|A0A5F8MPP0-1|A0A5F8MPP0_MOUSE Isoform 1 of Pleckstrin homology domain-containing, family G (with RhoGef domain) member 1 OS=Mus musculus OX=10090 GN=Plekhg1 PE=1 SV=1 CANONICAL=A0A5F8MPP0-1" }, "locus": { "chromosome": "10", "start_pos": 3914449, "end_pos": 3784959, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000239159.2", "url": "https://www.ensembl.org/id/ENSMUST00000239159.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000159056.2", "url": "https://www.ensembl.org/id/ENSMUSP00000159056.2" } ] } }, { "isoform_ac": "F6S200-1", "url": "https://www.uniprot.org/uniprot/A0A5F8MPP0#F6S200-1", "sequence": { "sequence": "XFSQSGAPLLTLQSVRLQFQETDGHRHLQLDVPSAVSLVPDPRTTAEPSESPEPKTMELSDSDRPISFGSTSSSASSRDSHGSFGSRMTLVSNSHLGLFHQDKEAGAIKLELVPARPFSSSELQRDKPAGPQNMNGVSEKQPRTPWRMDTSGTPQTTADSATSPKLLYVDRVVQEILETERTYVQDLKSIVEGYLECIRDQTKLPLVTEDRAALFGNIQDIYHFNSELLQDLENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILTKFFRERQETLRHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKATEGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQSLLTNWEGPDLTSYGELVLEGTFRIQKAKKERTLFLLDQLLLITKKRDDTFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQHTVQAKSQQDKRLWVLHLKRLILENHAAAAKIPAKAKQAILEMDAIHYPGFCYSPEGEMKTPCGSAPHRLRRKSEPSSRSHKVLKTSETSQDIQKVSREESPSQLTSAVPAQRNCQPGSAAVINMLRGGGGVRSPWTDHHIRQRTDHHIRQPLFPSRRSPQENEDDDDDYQMFVPSFSSSDLNSTRLCEENASSRPCSWHLGLIEPTEISSSGHRIVRRASSAGESNACPPEVRIRDCDDSQYCPGRQLQNSPRPGGERGMTPYGSSVELTIDDIDHVYDNISFEDLKLMVAKRDETECSFSKPSRDSVRPKSTPELAFSKRQVSHSTSSLHSRKEAGLGGQEASTQSVHEHQEVEENIYDTIGLPDPPSMNLNHSSLHQPKRSTFLGLEADFACCDSLRPFVSQDSLQFSEDDISYHQGPSDTEYLSLLYDSPRCNLPIADKALSDKLSEEVDEIWNDLENYIKKNEDKSRDRLLAAFPVSKDDAPERLYVDSTHELGRDTGHATSMLALPTSQTFLLPGKSRVVRASRANCSLDNDIISTEGSFLSLNQLSLASDGPPVDNPYDLANCSLPQTDPENPDPGMEVTDKTKSRVFMMARQYSQKIKKVNQILKVKSPELEQPPSSQHRPSHKDLVAILEEKRQGGPAIGARIAEYSQLYDQIVFRETPLKAQKDGWASPQGPTLHRPVSPPQAQGAGEDWLWHSPYSNGELADFSPQTEQDSKSKYPITLESTTKIRPRQLSGACSVPSLQVSDPLLGSVQQRCSVVVSQPHKENSGQSPLYNSLGRKAISAKPQPYSRPQSSSSILINKSLDSINYPSETETKQLLSSQKSPRGASQQDLPSGLANSCQQDRGKRSDLTLQDSQKVLVVNRNLPLSAQIATQNYFCNFKDPEGDEDDYVEIKSEEDEVRLDLSPRRGRKSDPQTPDPDCSDSICSHSTPYSLKEPVSGRLGLPPYLTACKDSDKLNDYLWRGPSPNQQNIVQSLREKFQCLSSSSFA", "length": 1446, "header": "tr|F6S200-1|A0A5F8MPP0_MOUSE Computationally mapped isoform of Pleckstrin homology domain-containing, family G (with RhoGef domain) member 1 OS=Mus musculus OX=10090 GN=Plekhg1 PE=1 SV=1 CANONICAL=A0A5F8MPP0-1" }, "locus": { "chromosome": "10", "start_pos": 3914451, "end_pos": 3822667, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000136671.8", "url": "https://www.ensembl.org/id/ENSMUST00000136671.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000119950.2", "url": "https://www.ensembl.org/id/ENSMUSP00000119950.2" } ] } }, { "isoform_ac": "F7C583-1", "url": "https://www.uniprot.org/uniprot/A0A5F8MPP0#F7C583-1", "sequence": { "sequence": "XKLPLVTEDRAALFGNIQDIYHFNSELLQDLENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILTKFFRERQETLRHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKATEGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQSLLTNWEGPDLTSYGELVLEGTFRIQKAKKERTLFLLDQLLLITKKRDDTFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQHTVQAKSQQDKRLWVLHLKRLILENHAAAAKIPAKAKQAILEMDAIHYPGFCYSPEGEMKTPCGSAPHRLRRKSEPSSRSHKVLKTSETSQDIQKVSREESPSQLTSAVPAQRNCQPGSAAVINMLRGGGGVRSPWTDHHIRQRTDHHIRQPLFPSRRSPQENEDDDDDYQMFVPSFSSSDLNSTRLCEENASSRPCSWHLGLIEPTEISSSGHRIVRRASSAGESNACPPEVRIRDCDDSQYCPGRQLQNSPRPGGERGMTPYGSSVELTIDDIDHVYDNISFEDLKLMVAKRDETECSFSKPSRDSVRPKSTPELAFSKRQVSHSTSSLHSRKEAGLGGQEASTQSVHEHQEVEENIYDTIGLPDPPSMNLNHSSLHQPKRSTFLGLEADFACCDSLRPFVSQDSLQFSEDDISYHQGPSDTEYLSLLYDSPRCNLPIADKALSDKLSEEVDEIWNDLENYIKKNEDKSRDRLLAAFPVSKDDAPERLYVDSTHELGRDTGHATSMLALPTSQTFLLPGKSRVVRASRANCSLDNDIISTEGSFLSLNQLSLASDGPPVDNPYDLANCSLPQTDPENPDPGMEVTDKTKSRVFMMARQYSQKIKKVNQILKVKSPELEQPPSSQHRPSHKDLVAILEEKRQGGPAIGARIAEYSQLYDQIVFRETPLKAQKDGWASPQGPTLHRPVSPPQAQGAGEDWLWHSPYSNGELADFSPQTEQDSKSKYPITLESTTKIRPRQLSGACSVPSLQVSDPLLGSVQQRCSVVVSQPHKENSGQSPLYNSLGRKAISAKPQPYSRPQSSSSILINKSLDSINYPSETETKQLLSSQKSPRGASQQDLPSGLANSCQQDRGKRSDLTLQDSQKVLVVNRNLPLSAQIATQNYFCNFKDPEGDEDDYVEIKSEEDEVRLDLSPRRGRKSDPQTPDPDCSDSICSHSTPYSLKEPVSGRLGLPPYLTAFSYSTSL", "length": 1213, "header": "tr|F7C583-1|A0A5F8MPP0_MOUSE Computationally mapped isoform of Pleckstrin homology domain-containing, family G (with RhoGef domain) member 1 OS=Mus musculus OX=10090 GN=Plekhg1 PE=1 SV=1 CANONICAL=A0A5F8MPP0-1" }, "locus": { "chromosome": "10", "start_pos": 3915532, "end_pos": 3853586, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000154727.2", "url": "https://www.ensembl.org/id/ENSMUST00000154727.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000122131.2", "url": "https://www.ensembl.org/id/ENSMUSP00000122131.2" } ] } }, { "isoform_ac": "F7CES2-1", "url": "https://www.uniprot.org/uniprot/A0A5F8MPP0#F7CES2-1", "sequence": { "sequence": "XSFLSLNQLSLASDGPPVDNPYDLANCSLPQTDPENPDPGMEVTDKTKSRVFMMARQYSQKIKKVNQILKVKSPELEQPPSSQHRPSHKDLVAILEEKRQGGPAIGRRNRMDRFSRLLRMGLTTLPGACSRCCAEGRALYSPAETLEHLY", "length": 150, "header": "tr|F7CES2-1|A0A5F8MPP0_MOUSE Computationally mapped isoform of Pleckstrin homology domain-containing, family G (with RhoGef domain) member 1 OS=Mus musculus OX=10090 GN=Plekhg1 PE=1 SV=1 CANONICAL=A0A5F8MPP0-1" }, "locus": { "chromosome": "10", "start_pos": 3910223, "end_pos": 3907891, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000141367.2", "url": "https://www.ensembl.org/id/ENSMUST00000141367.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000116652.2", "url": "https://www.ensembl.org/id/ENSMUSP00000116652.2" } ] } }, { "isoform_ac": "Q3UX37-1", "url": "https://www.uniprot.org/uniprot/A0A5F8MPP0#Q3UX37-1", "sequence": { "sequence": "MELSDSDRPISFGSTSSSASSRDSHGSFGSRMTLVSNSHLGLFHQDKEAGAIKLELVPARPFSSSELQRDKPAGPQNMNGVSEKQPRTPWRMDTSGTPQTTADSATSPKLLYVDRVVQEILETERTYVQDLKSIVEGYLECIRDQTKLPLVTEDRAALFGNIQDIYHFNSELLQDLENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILTKFFRERQETLRHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKATEGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQSLLTNWEGPDLTSYGELVLEGTFRIQKAKKERTLFLLDQLLLITKKRDDTFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQHTVQAKSQQDKRLWVLHLKRLILENHAAAAKIPAKAKQAILEMDAIHYPGFCYSPEGEMKTPCGSAPHRLRRKSEPSSRSHKVLKTSETSQDIQKVSREESPSQLTSAVPAQRNCQPGSAAVINMLRGGGGVRSPWTDHHIRQRTDHHIRQPLFPSRRSPQENEDDDDDYQMFVPSFSSSDLNSTRLCEENASSRPCSWHLGLIEPTEISSSGHRIVRRASSAGESNACPPEVRIRDCDDSQYCPGRQLQNSPRPGGERGMTPYGSSVELTIDDIDHVYDNISFEDLKLMVAKRDETECSFSKPSRDSVRPKSTPELAFSKRQVSHSTSSLHSRKEAGLGGQEASTQSVHEHQEVEENIYDTIGLPDPPSMNLNHSSLHQPKRSTFLGLEADFACCDSLRPFVSQDSLQFSEDDISYHQGPSDTEYLSLLYDSPRCNLPIADKALSDKLSEEVDEIWNDLENYIKKNEDKSRDRLLAAFPVSKDDAPERLYVDSTHELGRDTGHATSMLALPTSQTFLLPGKSRVVRASRANCSLDNDIISTEGSFLSLNQLSLASDGPPVDNPYDLANCSLPQTDPENPDPGMEVTDKTKSRVFMMARQYSQKIKKVNQILKVKSPELEQPPSSQHRPSHKDLVAILEEKRQGGPAIGARIAEYSQLYDQIVFRETPLKAQKDGWASPQGPTLHRPVSPPQAQGAGEDWLWHSPYSNGELADFSPQTEQDSKSKYPITLESTTKIRPRQLSGACSVPSLQVSDPLLGSVQQRCSVVVSQPHKENSGQSPLYNSLGRKAISAKPQPYSRPQSSSSILINKSLDSINYPSETETKQLLSSQKSPRGASQQDLPSGLANSCQQDRGKRSDLTLQDSQKVLVVNRNLPLSAQIATQNYFCNFKDPEGDEDDYVEIKSEEDEVRLDLSPRRGRKSDPQTPDPDCSDSICSHSTPYSLKEPVSGRLGLPPYLTACKDSDKLNDYLWRGPSPNQQNIVQSLREKFQCLSSSSFA", "length": 1390, "header": "tr|Q3UX37-1|A0A5F8MPP0_MOUSE Computationally mapped isoform of Pleckstrin homology domain-containing, family G (with RhoGef domain) member 1 OS=Mus musculus OX=10090 GN=Plekhg1 PE=1 SV=1 CANONICAL=A0A5F8MPP0-1" }, "locus": { "chromosome": "10", "start_pos": 3914449, "end_pos": 3823034, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000120274.8", "url": "https://www.ensembl.org/id/ENSMUST00000120274.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000114056.2", "url": "https://www.ensembl.org/id/ENSMUSP00000114056.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Large-scale phosphorylation analysis of mouse liver.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2007", "authors": "Beausoleil S.A., Gerber S.A., Gygi S.P., Villen J.", "evidence": [ { "database": "UniProtKB", "id": "F7C583", "url": "https://www.uniprot.org/uniprot/F7C583" }, { "database": "UniProtKB", "id": "Q3UX37", "url": "https://www.uniprot.org/uniprot/Q3UX37" }, { "database": "UniProtKB", "id": "F6S200", "url": "https://www.uniprot.org/uniprot/F6S200" } ], "reference": [ { "type": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" } ] } ], "pathway": [ { "id": "mmu:213783", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:213783", "resource": "KEGG Pathway" }, { "id": "R-MMU-9013148", "name": "CDC42 GTPase cycle", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9013148", "resource": "Reactome", "description": "CDC42 GTPase cycle" }, { "id": "R-MMU-9013149", "name": "RAC1 GTPase cycle", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9013149", "resource": "Reactome", "description": "RAC1 GTPase cycle" } ], "orthologs": [ { "uniprot_canonical_ac": "D4AE81-1", "protein_name": "Pleckstrin homology and RhoGEF domain-containing G1", "gene_name": "Plekhg1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLSTTMVGTLVRGWRNRSGIRIQDGHRRLQLEVPSAVSRVPDPRTTTEPSQCPERKTMELSDSDRPISFGSTSSSASSRDSHGSFGSRMTLDKEAGAIKLELVPAQPFSSSELQKDNPRRATNMDGVGEKQPRAPWRVDTNGTPQTTADSATSPKLLYVDRVVQEILETERTYVQDLKSIVEDYLACIRDQTKLPLGTEDRAALFGNIQDIYHFNSELLQELENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKMLAKFFRERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIQRAKNERTLFLLDKLLLITKKREDTFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKSPKLQHTVQAKSQQEKRLWILHLKRLILENHAAKIPAKAKQAILEMDAIHHPGFCYDPKGEVKTPCGSAPHRLRRKSEPSSRSHKVLKTSGKEESSSQLTSAVPAQRNRQPGNAAVLNMLRGGGSVRGLWMDHHIQQPFFPSRRTPQENEDDDDDYQMFVPSFSSSDLNSTRLCEENTSSRPCSWHLGLIEPTEISSSGHRIVRRASSAGESNACPPEVRLRDSDGSQYCPGREMQNSPQPGGQGGMTPFGSSVELTIDDIDHVYDNISFEDLKLMVAKRDETESSFSKSSRDSVRPKSTPELAFSKRQASHSTSSLHSKKETASSGQEASNQSIHEHQEVEENIYDTIGLPDPPSLNFQRSSLQQPKRSTFLGLEADFACCDSLRPFVSQDRLQFSEDDISYHQGPSDTDYLSLLYDSPRCNLPIADKTLSDKLSEEVDEIWNDLENYIKKNEDKSRDRLLAAFPVSKDDVPERLYVESTQELSRDAGRATSMLALPGSQTFLTPGESRVVRASRANCSLEDDLISTEGSFLSLNQLSLVSDEPSEDNPYDLASCSLPQTDPENPDPRMEITDKTKSRVFMMARQYSQKIKKVNQLLKVKSPELEQPLSSQHRPIHKDLVAILEEKRQGGPAIGARIAEYSQLYDQIVFRETPLKSQKDGWTSTQEPALHRPASPPQVQGAGEDWLWHSSYSNREVADFSPQTEQDSKSKYPVTLESITKIMPRQLSAACSVPSLQGSDPLLGSVQQRCSVVVSQPHKENSGQGHLYNSLGRKAISAKLQPYSRPQSSSSVLINKSLDSINYPSETEKKQLLSLQKSPRGASQQDLLSGLADSCQQDTGKQSDLTLQDSQKVLVVNRNLPLSAQIASQNYFSNFKETEGDEDDYVEIKSEEDEVRLDLSPRRNRKSDPKIPDPDCSDNICRHNTPYSLKEPVSGRLGLPPYLTACKDSDKLNDYLWRGPSPNQQNIVQSLREKFQCLSSSSFA", "length": 1417 }, "evidence": [ { "id": "41505262", "url": "http://www.informatics.jax.org/homology/41505262", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9ULL1-1", "protein_name": "Pleckstrin homology domain-containing family G member 1", "gene_name": "PLEKHG1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MELSDSDRPVSFGSTSSSASSRDSHGSFGSRMTLVSNSHMGLFNQDKEVGAIKLELIPARPFSSSELQRDNPATGQQNADEGSERPPRAQWRVDSNGAPKTIADSATSPKLLYVDRVVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSELLQDLENCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIQRAKNERTLFLFDKLLLITKKRDDTFTYKAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQHTVQAKSQQDKRLWVLHLKRLILENHAAKIPAKAKQAILEMDAIHHPGFCYSPEGGTKALFGSKEGSAPYRLRRKSEPSSRSHKVLKTSETAQDIQKVSREEGSPQLSSARPSPAQRNSQPSSSTMISVLRAGGALRNIWTDHQIRQALFPSRRSPQENEDDEDDYQMFVPSFSSSDLNSTRLCEDSTSSRPCSWHMGQMESTETSSSGHRIVRRASSAGESNTCPPEIGTSDRTRELQNSPKTEGQEEMTPFGSSIELTIDDIDHVYDNISYEDLKLMVAKREEAESTPSKSARDSVRPKSTPELAFTKRQAGHSKGSLYAQTDGTLSGGEASSQSTHELQAVEENIYDTIGLPDPPSLGFKCSSLKRAKRSTFLGLEADFVCCDSLRPFVSQDSLQLSEDEAPYHQATPDHGYLSLLYDSPSGNLSMPHKPVSDKLSEEVDEIWNDLENYIKKNEDKARDRLLAAFPVSKDDVPDRLHAESTPELSRDVGRSVSTLSLPESQALLTPVKSRAGRASRANCPFEEDLISKEGSFMSLNRLSLASEMPLMDNPYDLANSGLSQTDPENPDLGMEATDKTKSRVFMMARQYSQKIKKANQLLKVKSLELEQPPASQHQKSMHKDLAAILEEKKQGGPAIGARIAEYSQLYDQIVFRESPLKIQKDGWASPQESSLLRSVSPSQVHHGSGDWLLHSTYSNGELADFCLPPEQDLRSRYPTFEINTKSTPRQLSAACSVPSLQTSDPLPGSVQRCSVVVSQPNKENWCQDHLYNSLGRKGISAKSQPYHRSQSSSSVLINKSMDSINYPSDVGKQQLLSLHRSSRCESHQDLLPDIADSHQQGTEKLSDLTLQDSQKVVVVNRNLPLNAQIATQNYFSNFKETDGDEDDYVEIKSEEDESELELSHNRRRKSDSKFVDADFSDNVCSGNTLHSLNSPRTPKKPVNSKLGLSPYLTPYNDSDKLNDYLWRGPSPNQQNIVQSLREKFQCLSSSSFA", "length": 1385 }, "evidence": [ { "id": "41505262", "url": "http://www.informatics.jax.org/homology/41505262", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "A0A5F8MPP0", "url": "https://www.uniprot.org/uniprot/A0A5F8MPP0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "A0A5F8MPP0", "url": "https://www.uniprot.org/uniprot/A0A5F8MPP0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1036, "end_pos": 1038, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1276, "end_pos": 1278, "annotation": "n_glycosylation_sequon" }, { "start_pos": 16, "end_pos": 18, "annotation": "n_glycosylation_sequon" }, { "start_pos": 650, "end_pos": 652, "annotation": "n_glycosylation_sequon" }, { "start_pos": 658, "end_pos": 660, "annotation": "n_glycosylation_sequon" }, { "start_pos": 748, "end_pos": 750, "annotation": "n_glycosylation_sequon" }, { "start_pos": 841, "end_pos": 843, "annotation": "n_glycosylation_sequon" }, { "start_pos": 999, "end_pos": 1001, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ] }