{ "uniprot_canonical_ac": "A0A3B0IP20-1", "uniprot_ac": "A0A3B0IP20", "uniprot_id": "A0A3B0IP20_RAT", "mass": { "chemical_mass": 36335.0, "monoisotopic_mass": 36335.0 }, "refseq": { "ac": "NP_001178820", "name": "C1q and TNF related 9 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178820" }, "gene_names": [ { "name": "C1qtnf9", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A3B0IP20", "id": "A0A3B0IP20" }, { "name": "Adif1; RGD1560876", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006252196", "id": "XP_006252196" }, { "name": "Adif1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A3B0IP20", "id": "A0A3B0IP20" }, { "name": "C1qtnf9", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006252196", "id": "XP_006252196" } ], "protein_names": [ { "name": "Adiponectin f1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A3B0IP20#names_and_taxonomy", "id": "A0A3B0IP20" }, { "name": "C1q and TNF related 9 isoform X1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006252196", "id": "XP_006252196" }, { "name": "C1q and TNF-related 9", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A3B0IP20#names_and_taxonomy", "id": "A0A3B0IP20" } ], "function": [ { "annotation": "Autocrine CTRP9 of cardiomyocyte origin protects against myocardial ischemia/reperfusion injury via CRT association. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001178820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178820" }, { "database": "PubMed", "id": "29925877", "url": "https://glygen.org/publication/PubMed/29925877" } ] }, { "annotation": "C1q/TNF-related protein-9 ameliorates hypoxia-induced pulmonary hypertension by regulating secretion of endothelin-1 and nitric oxide mediated by AMPK in rats. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001178820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178820" }, { "database": "PubMed", "id": "34059748", "url": "https://glygen.org/publication/PubMed/34059748" } ] }, { "annotation": "CTRP9 Ameliorates Atrial Inflammation, Fibrosis, and Vulnerability to Atrial Fibrillation in Post-Myocardial Infarction Rats.", "evidence": [ { "database": "RefSeq", "id": "NP_001178820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178820" }, { "database": "PubMed", "id": "31623508", "url": "https://glygen.org/publication/PubMed/31623508" } ] }, { "annotation": "CTRP9 Mediates Protective Effects in Cardiomyocytes via AMPK- and Adiponectin Receptor-Mediated Induction of Anti-Oxidant Response. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001178820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178820" }, { "database": "PubMed", "id": "32429302", "url": "https://glygen.org/publication/PubMed/32429302" } ] }, { "annotation": "CTRP9 improved post-myocardial infarction early cardiac function.", "evidence": [ { "database": "RefSeq", "id": "NP_001178820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178820" }, { "database": "PubMed", "id": "30953351", "url": "https://glygen.org/publication/PubMed/30953351" } ] }, { "annotation": "CTRP9 protects against acute cardiac injury following ischemia-reperfusion via an AMPK-dependent mechanism.", "evidence": [ { "database": "RefSeq", "id": "NP_001178820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178820" }, { "database": "PubMed", "id": "22514273", "url": "https://glygen.org/publication/PubMed/22514273" } ] }, { "annotation": "CTRP9 regulates hypoxia-mediated human pulmonary artery smooth muscle cell proliferation, apoptosis and migration via TGF-beta1/ERK1/ERK2 signaling pathway.", "evidence": [ { "database": "RefSeq", "id": "NP_001178820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178820" }, { "database": "PubMed", "id": "28688765", "url": "https://glygen.org/publication/PubMed/28688765" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A3B0IP20", "url": "https://www.uniprot.org/uniprot/A0A3B0IP20" } ], "common_name": "Rat" } ], "gene": [ { "name": "C1qtnf9", "url": "https://www.uniprot.org/uniprot/A0A3B0IP20", "locus": { "chromosome": "15", "start_pos": 41069507, "end_pos": 41081159, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000013793", "url": "https://www.ensembl.org/id/ENSRNOG00000013793" } ] } } ], "crossref": [ { "id": "ENSRNOG00000013793", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000013793", "database": "Bgee" }, { "id": "364395", "url": "https://www.ncbi.nlm.nih.gov/gene/364395", "database": "GeneID" }, { "id": "IPR001073", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001073", "database": "InterPro" }, { "id": "IPR008160", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008160", "database": "InterPro" }, { "id": "IPR008983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008983", "database": "InterPro" }, { "id": "SVGYKGQ", "url": "https://omabrowser.org/oma/group/SVGYKGQ/", "database": "OMA" }, { "id": "1258047at2759", "url": "http://www.orthodb.org/?query=1258047at2759", "database": "OrthoDB" }, { "id": "PF00386", "url": "http://pfam.xfam.org/family/PF00386", "database": "Pfam" }, { "id": "PF01391", "url": "http://pfam.xfam.org/family/PF01391", "database": "Pfam" }, { "id": "PR_D3ZJ76", "url": "http://purl.obolibrary.org/obo/PR_D3ZJ76", "database": "PRO" }, { "id": "NP_001178820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178820", "database": "RefSeq" }, { "id": "1560876", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1560876", "database": "RGD" }, { "id": "A0A3B0IP20", "url": "https://www.uniprot.org/uniprot/A0A3B0IP20", "database": "UniProtKB" }, { "id": "A0A3B0IP20-1", "url": "https://www.uniprot.org/uniprot/A0A3B0IP20-1", "database": "UniProtKB" }, { "id": "D3ZJ76", "url": "https://www.uniprot.org/uniprot/D3ZJ76", "database": "UniProtKB" }, { "id": "D3ZJ76-1", "url": "https://www.uniprot.org/uniprot/D3ZJ76-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MPLPVSVSLFQSRPCRLTMRIWWLLLVMDAGSVFSQDTCRQGHSGIPGTPGHNGLPGRDGRDGAKGDKGDTGEPGHPGGPGKDGIRGEKGEPGADGRVEAKGIKGDPGSRGSPGKHGPKGSIGPTGEQGLPGETGPQGQKGDKGEVGPTGPEGLMGSTGPLGPKGLPGPVGPIGKPGPRGEAGPMGPQGEPGVRGMRGWKGDRGEKGKVGEAPMVPKSAFTVGLTVISKFPPPDVPIKFDKILYNEQNHYNVATGKFTCHVAGVYYFTYHITVFSRNVQVSLVKNGVKVLHTKDGYMSSEDQASGGIVLELKLGDEVWMQVTGGERFNGLFADEDDDTTFTGFLLFSSS", "length": 349, "header": "tr|A0A3B0IP20-1|A0A3B0IP20_RAT Isoform 1 of Adiponectin f1 OS=Rattus norvegicus OX=10116 GN=C1qtnf9 PE=4 SV=1 CANONICAL=A0A3B0IP20-1" }, "isoforms": [ { "isoform_ac": "A0A3B0IP20-1", "url": "https://www.uniprot.org/uniprot/A0A3B0IP20#A0A3B0IP20-1", "sequence": { "sequence": "MPLPVSVSLFQSRPCRLTMRIWWLLLVMDAGSVFSQDTCRQGHSGIPGTPGHNGLPGRDGRDGAKGDKGDTGEPGHPGGPGKDGIRGEKGEPGADGRVEAKGIKGDPGSRGSPGKHGPKGSIGPTGEQGLPGETGPQGQKGDKGEVGPTGPEGLMGSTGPLGPKGLPGPVGPIGKPGPRGEAGPMGPQGEPGVRGMRGWKGDRGEKGKVGEAPMVPKSAFTVGLTVISKFPPPDVPIKFDKILYNEQNHYNVATGKFTCHVAGVYYFTYHITVFSRNVQVSLVKNGVKVLHTKDGYMSSEDQASGGIVLELKLGDEVWMQVTGGERFNGLFADEDDDTTFTGFLLFSSS", "length": 349, "header": "tr|A0A3B0IP20-1|A0A3B0IP20_RAT Isoform 1 of Adiponectin f1 OS=Rattus norvegicus OX=10116 GN=C1qtnf9 PE=4 SV=1 CANONICAL=A0A3B0IP20-1" }, "locus": { "chromosome": "15", "start_pos": 34922782, "end_pos": 34915275, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000095495.1", "url": "https://www.ensembl.org/id/ENSRNOT00000095495.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000076970.1", "url": "https://www.ensembl.org/id/ENSRNOP00000076970.1" } ] } }, { "isoform_ac": "D3ZJ76-1", "url": "https://www.uniprot.org/uniprot/A0A3B0IP20#D3ZJ76-1", "sequence": { "sequence": "MRIWWLLLVMDAGSVFSQDTCRQGHSGIPGTPGHNGLPGRDGRDGAKGDKGDTGEPGHPGGPGKDGIRGEKGEPGADGRVEAKGIKGDPGSRGSPGKHGPKGSIGPTGEQGLPGETGPQGQKGDKGEVGPTGPEGLMGSTGPLGPKGLPGPVGPIGKPGPRGEAGPMGPQGEPGVRGMRGWKGDRGEKGKVGEAPMVPKSAFTVGLTVISKFPPPDVPIKFDKILYNEQNHYNVATGKFTCHVAGVYYFTYHITVFSRNVQVSLVKNGVKVLHTKDGYMSSEDQASGGIVLELKLGDEVWMQVTGGERFNGLFADEDDDTTFTGFLLFSSS", "length": 331, "header": "tr|D3ZJ76-1|D3ZJ76_RAT Computationally mapped isoform of C1q and TNF-related 9 OS=Rattus norvegicus OX=10116 GN=C1qtnf9 PE=4 SV=3 CANONICAL=A0A3B0IP20-1" }, "locus": { "chromosome": "15", "start_pos": 34922782, "end_pos": 34915329, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000018533.8", "url": "https://www.ensembl.org/id/ENSRNOT00000018533.8" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000018533.7", "url": "https://www.ensembl.org/id/ENSRNOP00000018533.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "CTRP9 protein protects against myocardial injury following ischemia-reperfusion through AMP-activated protein kinase (AMPK)-dependent mechanism.", "journal": "The Journal of biological chemistry", "date": "2012", "authors": "Kambara T, Ohashi K, Shibata R, Ogura Y, Maruyama S, Enomoto T, Uemura Y, Shimizu Y, Yuasa D, Matsuo K, Miyabe M, Kataoka Y, Murohara T, Ouchi N", "evidence": [ { "database": "RefSeq", "id": "NP_001178820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178820" } ], "reference": [ { "type": "PubMed", "id": "22514273", "url": "https://glygen.org/publication/PubMed/22514273" } ] }, { "title": "CTRP9 regulates hypoxia-mediated human pulmonary artery smooth muscle cell proliferation, apoptosis and migration via TGF-beta1/ERK1/2 signaling pathway.", "journal": "Biochemical and biophysical research communications", "date": "2017", "authors": "Li YX, Run L, Shi T, Zhang YJ", "evidence": [ { "database": "RefSeq", "id": "NP_001178820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178820" } ], "reference": [ { "type": "PubMed", "id": "28688765", "url": "https://glygen.org/publication/PubMed/28688765" } ] }, { "title": "Cardiac-derived CTRP9 protects against myocardial ischemia/reperfusion injury via calreticulin-dependent inhibition of apoptosis.", "journal": "Cell death & disease", "date": "2018", "authors": "Zhao D, Feng P, Sun Y, Qin Z, Zhang Z, Tan Y, Gao E, Lau WB, Ma X, Yang J, Yu S, Xu X, Yi D, Yi W", "evidence": [ { "database": "RefSeq", "id": "NP_001178820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178820" } ], "reference": [ { "type": "PubMed", "id": "29925877", "url": "https://glygen.org/publication/PubMed/29925877" } ] }, { "title": "Comparative genomic analysis of eutherian adiponectin genes.", "journal": "Heliyon", "date": "2018", "authors": "Premzl M.", "evidence": [ { "database": "UniProtKB", "id": "A0A3B0IP20", "url": "https://www.uniprot.org/uniprot/A0A3B0IP20" } ], "reference": [ { "type": "PubMed", "id": "30003153", "url": "https://glygen.org/publication/PubMed/30003153" } ] }, { "title": "C1q/TNF-related protein-9 promotes macrophage polarization and improves cardiac dysfunction after myocardial infarction.", "journal": "Journal of cellular physiology", "date": "2019", "authors": "Liu M, Yin L, Li W, Hu J, Wang H, Ye B, Tang Y, Huang C", "evidence": [ { "database": "RefSeq", "id": "NP_001178820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178820" } ], "reference": [ { "type": "PubMed", "id": "30953351", "url": "https://glygen.org/publication/PubMed/30953351" } ] }, { "title": "CTRP9 Ameliorates Atrial Inflammation, Fibrosis, and Vulnerability to Atrial Fibrillation in Post-Myocardial Infarction Rats.", "journal": "Journal of the American Heart Association", "date": "2019", "authors": "Liu M, Li W, Wang H, Yin L, Ye B, Tang Y, Huang C", "evidence": [ { "database": "RefSeq", "id": "NP_001178820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178820" } ], "reference": [ { "type": "PubMed", "id": "31623508", "url": "https://glygen.org/publication/PubMed/31623508" } ] }, { "title": "CTRP9 Mediates Protective Effects in Cardiomyocytes via AMPK- and Adiponectin Receptor-Mediated Induction of Anti-Oxidant Response.", "journal": "Cells", "date": "2020", "authors": "Niemann B, Li L, Siegler D, Siegler BH, Knapp F, Hanna J, Aslam M, Kracht M, Schulz R, Rohrbach S", "evidence": [ { "database": "RefSeq", "id": "NP_001178820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178820" } ], "reference": [ { "type": "PubMed", "id": "32429302", "url": "https://glygen.org/publication/PubMed/32429302" } ] }, { "title": "C1q/TNF-related protein-9 ameliorates hypoxia-induced pulmonary hypertension by regulating secretion of endothelin-1 and nitric oxide mediated by AMPK in rats.", "journal": "Scientific reports", "date": "2021", "authors": "Jin Q, Su H, Yang R, Tan Y, Li B, Yi W, Dong Q, Zhang H, Xing W, Sun X", "evidence": [ { "database": "RefSeq", "id": "NP_001178820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178820" } ], "reference": [ { "type": "PubMed", "id": "34059748", "url": "https://glygen.org/publication/PubMed/34059748" } ] } ], "pathway": [], "orthologs": [ { "uniprot_canonical_ac": "B2RNN3-1", "protein_name": "Complement C1q and tumor necrosis factor-related protein 9B", "gene_name": "C1QTNF9B", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRIWWLLLAIEICTGNINSQDTCRQGHPGIPGNPGHNGLPGRDGRDGAKGDKGDAGEPGCPGSPGKDGTSGEKGERGADGKVEAKGIKGDQGSRGSPGKHGPKGLAGPMGEKGLRGETGPQGQKGNKGDVGPTGPEGPRGNIGPLGPTGLPGPMGPIGKPGPKGEAGPTGPQGEPGVRGIRGWKGDRGEKGKIGETLVLPKSAFTVGLTVLSKFPSSDVPIKFDKILYNEFNHYDTAVGKFTCHIAGVYYFTYHITVFSRNVQVSLVKNGVKILHTRDAYVSSEDQASGSIVLQLKLGDEMWLQVTGGERFNGLFADEDDDTTFTGFLLFSSQ", "length": 333 }, "evidence": [ { "id": "41498862", "url": "http://www.informatics.jax.org/homology/41498862", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "P0C862-1", "protein_name": "Complement C1q and tumor necrosis factor-related protein 9A", "gene_name": "C1QTNF9", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRIWWLLLAIEICTGNINSQDTCRQGHPGIPGNPGHNGLPGRDGRDGAKGDKGDAGEPGRPGSPGKDGTSGEKGERGADGKVEAKGIKGDQGSRGSPGKHGPKGLAGPMGEKGLRGETGPQGQKGNKGDVGPTGPEGPRGNIGPLGPTGLPGPMGPIGKPGPKGEAGPTGPQGEPGVRGIRGWKGDRGEKGKIGETLVLPKSAFTVGLTVLSKFPSSDMPIKFDKILYNEFNHYDTAAGKFTCHIAGVYYFTYHITVFSRNVQVSLVKNGVKILHTKDAYMSSEDQASGGIVLQLKLGDEVWLQVTGGERFNGLFADEDDDTTFTGFLLFSSP", "length": 333 }, "evidence": [ { "id": "41498862", "url": "http://www.informatics.jax.org/homology/41498862", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q4ZJN1-1", "protein_name": "Complement C1q and tumor necrosis factor-related protein 9", "gene_name": "C1qtnf9", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRIWWLLLVMGACTRSVFSQDTCRQGHSGIPGNPGHNGLPGRDGRDGAKGDKGDAGEPGHPGGPGKDGIRGEKGEPGADGRVEAKGIKGDPGSRGSPGKHGPKGSIGPTGEQGLPGETGPQGQKGDKGEVGPTGPEGLMGSTGPLGPKGLPGPMGPIGKPGPRGEAGPMGPQGEPGVRGMRGWKGDRGEKGKVGEAPLVPKSAFTVGLTVISKFPPPDAPIKFDKILYNELNHYNVATGKFTCHVAGVYYFTYHITVFSRNVQVSLVKNGVKVLHTKDSYMSSEDQASGGIVQELKLGDEVWMQVTGGERFNGLFADEDDDTTFTGFLLFSSS", "length": 333 }, "evidence": [ { "id": "41498862", "url": "http://www.informatics.jax.org/homology/41498862", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "positive regulation of cellular response to insulin stimulus", "id": "GO:1900078", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900078", "evidence": [ { "database": "UniProtKB", "id": "A0A3B0IP20", "url": "https://www.uniprot.org/uniprot/A0A3B0IP20" } ], "pmid": "" }, { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "A0A3B0IP20", "url": "https://www.uniprot.org/uniprot/A0A3B0IP20" } ], "pmid": "" }, { "name": "energy homeostasis", "id": "GO:0097009", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097009", "evidence": [ { "database": "UniProtKB", "id": "A0A3B0IP20", "url": "https://www.uniprot.org/uniprot/A0A3B0IP20" } ], "pmid": "" }, { "name": "fatty acid oxidation", "id": "GO:0019395", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019395", "evidence": [ { "database": "UniProtKB", "id": "A0A3B0IP20", "url": "https://www.uniprot.org/uniprot/A0A3B0IP20" } ], "pmid": "" }, { "name": "positive regulation of protein serine/threonine kinase activity", "id": "GO:0071902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071902", "evidence": [ { "database": "UniProtKB", "id": "A0A3B0IP20", "url": "https://www.uniprot.org/uniprot/A0A3B0IP20" } ], "pmid": "" }, { "name": "negative regulation of cell size", "id": "GO:0045792", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045792", "evidence": [ { "database": "UniProtKB", "id": "A0A3B0IP20", "url": "https://www.uniprot.org/uniprot/A0A3B0IP20" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "A0A3B0IP20", "url": "https://www.uniprot.org/uniprot/A0A3B0IP20" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "A0A3B0IP20", "url": "https://www.uniprot.org/uniprot/A0A3B0IP20" } ], "pmid": "" }, { "name": "hormone activity", "id": "GO:0005179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005179", "evidence": [ { "database": "UniProtKB", "id": "A0A3B0IP20", "url": "https://www.uniprot.org/uniprot/A0A3B0IP20" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ] }