{ "uniprot_canonical_ac": "A0A140LIP2-1", "uniprot_ac": "A0A140LIP2", "uniprot_id": "A0A140LIP2_MOUSE", "mass": { "chemical_mass": 109644.0, "monoisotopic_mass": 109644.0 }, "refseq": { "ac": "NP_001181965", "name": "epithelial cell-transforming sequence 2 oncogene-like isoform 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181965" }, "gene_names": [ { "name": "Ect2l", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A140LIP2", "id": "A0A140LIP2" }, { "name": "C330021H03Rik; Gm10331", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181965", "id": "NP_001181965" }, { "name": "Ect2l", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181965", "id": "NP_001181965" } ], "protein_names": [ { "name": "Epithelial cell-transforming sequence 2 oncogene-like", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A140LIP2#names_and_taxonomy", "id": "A0A140LIP2" }, { "name": "epithelial cell-transforming sequence 2 oncogene-like isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181965", "id": "NP_001181965" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "A0A140LIP2", "url": "https://www.uniprot.org/uniprot/A0A140LIP2" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Ect2l", "url": "https://www.uniprot.org/uniprot/A0A140LIP2", "locus": { "chromosome": "10", "start_pos": 18210890, "end_pos": 18128903, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000071392", "url": "https://www.ensembl.org/id/ENSMUSG00000071392" } ] } } ], "crossref": [ { "id": "ENSMUSG00000071392", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000071392", "database": "Bgee" }, { "id": "cd00160", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00160", "database": "CDD" }, { "id": "100045792", "url": "https://www.ncbi.nlm.nih.gov/gene/100045792", "database": "GeneID" }, { "id": "IPR000219", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000219", "database": "InterPro" }, { "id": "IPR001810", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001810", "database": "InterPro" }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro" }, { "id": "IPR025592", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025592", "database": "InterPro" }, { "id": "IPR035899", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035899", "database": "InterPro" }, { "id": "IPR036047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036047", "database": "InterPro" }, { "id": "mmu:100045792", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:100045792", "database": "KEGG Pathway" }, { "id": "3641723", "url": "http://www.informatics.jax.org/marker/MGI:3641723", "database": "MGI" }, { "id": "GIDIFCP", "url": "https://omabrowser.org/oma/group/GIDIFCP/", "database": "OMA" }, { "id": "1047475at2759", "url": "http://www.orthodb.org/?query=1047475at2759", "database": "OrthoDB" }, { "id": "PF00621", "url": "http://pfam.xfam.org/family/PF00621", "database": "Pfam" }, { "id": "PF12937", "url": "http://pfam.xfam.org/family/PF12937", "database": "Pfam" }, { "id": "PF14252", "url": "http://pfam.xfam.org/family/PF14252", "database": "Pfam" }, { "id": "NP_001181965", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181965", "database": "RefSeq" }, { "id": "XP_017169236", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017169236", "database": "RefSeq" }, { "id": "A0A140LHP3", "url": "https://www.uniprot.org/uniprot/A0A140LHP3", "database": "UniProtKB" }, { "id": "A0A140LHP3-1", "url": "https://www.uniprot.org/uniprot/A0A140LHP3-1", "database": "UniProtKB" }, { "id": "A0A140LIP2", "url": "https://www.uniprot.org/uniprot/A0A140LIP2", "database": "UniProtKB" }, { "id": "A0A140LIP2-1", "url": "https://www.uniprot.org/uniprot/A0A140LIP2-1", "database": "UniProtKB" }, { "id": "A0A140LJD4", "url": "https://www.uniprot.org/uniprot/A0A140LJD4", "database": "UniProtKB" }, { "id": "A0A140LJD4-1", "url": "https://www.uniprot.org/uniprot/A0A140LJD4-1", "database": "UniProtKB" }, { "id": "F7CKP4", "url": "https://www.uniprot.org/uniprot/F7CKP4", "database": "UniProtKB" }, { "id": "F7CKP4-1", "url": "https://www.uniprot.org/uniprot/F7CKP4-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MSLGSLPLESVEVESFHTRFSAWTPFKNQSLNRQLFQERVTLISHWFDLWTNKQRREFLFVILSQCSKSQLRFIQDWFSERKQVARVDFSTVLPRFISLYIFSFLNPKDLCAAAQVSWPWKFLTEQDCLWMPKCTKFGWFLPYTPTQNEYGAWKHHYIACVSSLDWLTPREAAAVYGTLNEPKTEDEEFQERRREKCLRKIIWENIAFRKKELFKARPPWLSGTRCSRLLKSTSLPGGPQLWRDGTGFYEALERQFLRASLDALPKRSNISGSHSYPLLLKKHHHGVGRTDALPLHAILISSRIPAYEMVMESIKPDVVAVLYEHSGVTLEGLLQLTDRALQGRKAQSLGIFSSGNSREIDLLQGYKICIKNVLWPEVRDFWEKLGSRVATEEEGGHVDLFVPLGASEAGIEVLSQLSQLTGTWFSAPTGIATGSYQHILSDWLGPHQDRTPLSNYFSESKLQAWSSFTEFLEDTLKSVRKTLNPLFKNLQKSISGRMIGQFMFDTLGMDSILNNQGPAQALADGLMELSKEGSDKPLEFLSYFLLKKSSKTNKDFEGNYVLAECDLKETQDALMKEGSAIEDNSQDSKSSPGQSNLNVEVLVKLERKLQMNSVETRAQVVRELVQSERRYVQMLRIVQDVYAKPLRAALSSNRAILSAANIHIIFSDILHILNLNREFLDNLRDRLQEWSPAHCVGEIFIKFGSQLNIYTNFFNNYPVVLKTIEKCREMTPAFRAFLKRHDKTIVTKMLSLPELLIYPSRRFEEYIHLLYALRLHTPAGHVDRGDLTTAIDQVKKYKGYIDQIKENLKMREQLSDVQTLICGCPTLSEANRYLIRTQDVVQLHCCDEKMDFSLRLYEQIRDLSLLLFNDVLLVSSRSTSHTPFEKTSKTTYQFTASVALPRLLIEDIPDSKYIKNAFILRGSKREWICATEVSDDKFLWLSVLQHAIRSSMK", "length": 953, "header": "tr|A0A140LIP2-1|A0A140LIP2_MOUSE Isoform 1 of Epithelial cell-transforming sequence 2 oncogene-like OS=Mus musculus OX=10090 GN=Ect2l PE=1 SV=1 CANONICAL=A0A140LIP2-1" }, "isoforms": [ { "isoform_ac": "A0A140LHP3-1", "url": "https://www.uniprot.org/uniprot/A0A140LIP2#A0A140LHP3-1", "sequence": { "sequence": "MSLGSLPLESVEVESFHTRFSAWTPFKNQSLNRQLFQERVTLISHWFDLWTNKQRREFLFVILSQCSKSQLRFIQDWFSERKQVARVDFSTVLPRFISLYIFSFLNPKDLCAAAQVSWPWKFLTEQDCLWMPKCTKFGWFLPYTPTQNEYGAWKHHYIACVSSLDWLTPREAAAVYGTLNEPKTEDEEFQERRREKCLRKIIWENIAFRKKELFKARPPWLSGTRCSRLLKSTSLPGGPQLWRDGTGFYEALERQFLRASLDALPKRSNISGSHSYPLLLKKHHHGVGRTDALPLHAILISSRIPAYEMVMESIKPDVVAVLYEHSGVTLEGLLQLTDRALQGRKAQSLGIFSSGNSREIDLLQGYKICIKNVLWPEVRDFWEKLGSRVATEEEGGHVDLFVPLGASEAGIEVLSQLSQLTGTWFSAPTGIATGSYQHILSDWLGPHQDRTPLSNYFSESKLQAWSSFTEFLEDTLKSVRKTLNPLFKNLQKSISGRMIGQFMFDTLGMDSILNNQGPAQALADGLMELSKEGSEGSAIEDNSQDSKSSPGQSNLNVEVLVKLERKLQMNSVETRAQVVRELVQSERRYVQMLRIVQDVYAKPLRAALSSNRAILSAANIHIIFSDILHILNLNREFLDNLRDRLQEWSPAHCVGEIFIKFGSQLNIYTNFFNNYPVVLKTIEKCREMTPAFRAFLKRHDKTIVTKMLSLPELLIYPSRRFEEYIHLLYALRLHTPAGHVDRGDLTTAIDQVKKYKGYIDQENLKMREQLSDVQTLICGCPTLSEANRYLIRTQDVVQLHCCDEKMDFSLRLYEQIRDLSLLLFNDVLLVSSRSTSHTPFEKTSKTTYQFTASVALPRLLIEDIPDSKYIKNAFILRGSKREWICATEVSDDKFLWLSVLQHAIRSSMK", "length": 909, "header": "tr|A0A140LHP3-1|A0A140LIP2_MOUSE Computationally mapped isoform of Epithelial cell-transforming sequence 2 oncogene-like OS=Mus musculus OX=10090 GN=Ect2l PE=1 SV=1 CANONICAL=A0A140LIP2-1" }, "locus": { "chromosome": "10", "start_pos": 18077101, "end_pos": 18004773, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000207827.2", "url": "https://www.ensembl.org/id/ENSMUST00000207827.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000146490.2", "url": "https://www.ensembl.org/id/ENSMUSP00000146490.2" } ] } }, { "isoform_ac": "A0A140LIP2-1", "url": "https://www.uniprot.org/uniprot/A0A140LIP2#A0A140LIP2-1", "sequence": { "sequence": "MSLGSLPLESVEVESFHTRFSAWTPFKNQSLNRQLFQERVTLISHWFDLWTNKQRREFLFVILSQCSKSQLRFIQDWFSERKQVARVDFSTVLPRFISLYIFSFLNPKDLCAAAQVSWPWKFLTEQDCLWMPKCTKFGWFLPYTPTQNEYGAWKHHYIACVSSLDWLTPREAAAVYGTLNEPKTEDEEFQERRREKCLRKIIWENIAFRKKELFKARPPWLSGTRCSRLLKSTSLPGGPQLWRDGTGFYEALERQFLRASLDALPKRSNISGSHSYPLLLKKHHHGVGRTDALPLHAILISSRIPAYEMVMESIKPDVVAVLYEHSGVTLEGLLQLTDRALQGRKAQSLGIFSSGNSREIDLLQGYKICIKNVLWPEVRDFWEKLGSRVATEEEGGHVDLFVPLGASEAGIEVLSQLSQLTGTWFSAPTGIATGSYQHILSDWLGPHQDRTPLSNYFSESKLQAWSSFTEFLEDTLKSVRKTLNPLFKNLQKSISGRMIGQFMFDTLGMDSILNNQGPAQALADGLMELSKEGSDKPLEFLSYFLLKKSSKTNKDFEGNYVLAECDLKETQDALMKEGSAIEDNSQDSKSSPGQSNLNVEVLVKLERKLQMNSVETRAQVVRELVQSERRYVQMLRIVQDVYAKPLRAALSSNRAILSAANIHIIFSDILHILNLNREFLDNLRDRLQEWSPAHCVGEIFIKFGSQLNIYTNFFNNYPVVLKTIEKCREMTPAFRAFLKRHDKTIVTKMLSLPELLIYPSRRFEEYIHLLYALRLHTPAGHVDRGDLTTAIDQVKKYKGYIDQIKENLKMREQLSDVQTLICGCPTLSEANRYLIRTQDVVQLHCCDEKMDFSLRLYEQIRDLSLLLFNDVLLVSSRSTSHTPFEKTSKTTYQFTASVALPRLLIEDIPDSKYIKNAFILRGSKREWICATEVSDDKFLWLSVLQHAIRSSMK", "length": 953, "header": "tr|A0A140LIP2-1|A0A140LIP2_MOUSE Isoform 1 of Epithelial cell-transforming sequence 2 oncogene-like OS=Mus musculus OX=10090 GN=Ect2l PE=1 SV=1 CANONICAL=A0A140LIP2-1" }, "locus": { "chromosome": "10", "start_pos": 18077101, "end_pos": 18004773, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000208948.2", "url": "https://www.ensembl.org/id/ENSMUST00000208948.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000146899.2", "url": "https://www.ensembl.org/id/ENSMUSP00000146899.2" } ] } }, { "isoform_ac": "A0A140LJD4-1", "url": "https://www.uniprot.org/uniprot/A0A140LIP2#A0A140LJD4-1", "sequence": { "sequence": "MSLGSLPLESVEVESFHTRFSAWTPFKNQSLNRQDCLWMPKCTKFGWFLPYTPTQNEYGAWKHHYIACVSSLDWLTPREAAAVYGTLNEPKTEDEEFQERRREKCLRKIIWENIAFRKKELFKARPPWLSGTRCSRLLKSTSLPGGPQLWRDGTGFYEALERQFLRASLDALPKRSNISGSHSYPLLLKKHHHGVGRTDALPLHAILISSRIPAYEMVMESIKPDVVAVLYEHSGVTLEGLLQLTDRALQGRKAQSLGIFSSGNSREIDLLQGYKICIKNVLWPEVRDFWEKLGSRVATEEEGGHVDLFVPLGASEAGIEVLSQLSQLTGTWFSAPTGIATGSYQHILSDWLGPHQDRTPLSNYFSESKLQAWSSFTEFLEDTLKSVRKTLNPLFKNLQKSISGRMIGQFMFDTLGMDSILNNQGPAQALADGLMELSKEGSDKPLEFLSYFLLKKSSKTNKDFEGNYVLAECDLKETQDALMKEGSAIEDNSQDSKSSPGQSNLNVEVLVKLERKLQMNSVETRAQVVRELVQSERRYVQMLRIVQDVYAKPLRAALSSNRAILSAANIHIIFSDILHILNLNREFLDNLRDRLQEWSPAHCVGEIFIKFGSQLNIYTNFFNNYPVVLKTIEKCREMTPAFRAFLKRHDKTIVTKMLSLPELLIYPSRRFEEYIHLLYALRLHTPAGHVDRGDLTTAIDQVKKYKGYIDQIKENLKMREQLSDVQTLICGCPTLSEANRYLIRTQDVVQLHCCDEKMDFSLRLYEQIRDLSLLLFNDVLLVSSRSTSHTPFEKTSKTTYQFTASVALPRLLIEDIPDSKYIKNAFILRGSKREWICATEVSDDKFLWLSVLQHAIRSSMK", "length": 861, "header": "tr|A0A140LJD4-1|A0A140LJD4_MOUSE Computationally mapped isoform of Epithelial cell-transforming sequence 2 oncogene-like OS=Mus musculus OX=10090 GN=Ect2l PE=1 SV=1 CANONICAL=A0A140LIP2-1" }, "locus": { "chromosome": "10", "start_pos": 18077101, "end_pos": 18004773, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000209178.2", "url": "https://www.ensembl.org/id/ENSMUST00000209178.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000147170.2", "url": "https://www.ensembl.org/id/ENSMUSP00000147170.2" } ] } }, { "isoform_ac": "F7CKP4-1", "url": "https://www.uniprot.org/uniprot/A0A140LIP2#F7CKP4-1", "sequence": { "sequence": "MSLGSLPLESVEVESFHTRFSAWTPFKNQSLNRQLFQERVTLISHWFDLWTNKQRREFLFVILSQCSKSQLRFIQDWFSERKQVARVDFSTVLPRFISLYIFSFLNPKDLCAAAQVSWPWKFLTEQDCLWMPKCTKFGWFLPYTPTQNEYGAWKHHYIACVSSLDWLTPREAAAVYGTLNEPKTEDEEFQERRREKCLRKIIWENIAFRKKELFKARPPWLSGTRCSRLLKSTSLPGGPQLWRDGTGFYEALERQFLRASLDALPKRSNISGSHSYPLLLKKHHHGVGRTDALPLHAILISSRIPAYEMVMESIKPDVVAVLYEHSGVTLEGLLQLTDRALQGRKAQSLGIFSSGNSREIDLLQGYKICIKNVLWPEVRDFWEKLGSRVATEEEGGHVDLFVPLGASEAGIEVLSQLSQLTGTWFSAPTGIATGSYQHILSDWLGPHQDRTPLSNYFSESKLQAWSSFTEFLEDTLKSVRKTLNPLFKNLQKSISGRMIGQFMFDTLGMDSILNNQGPAQALADGLMELSKEGSEGSAIEDNSQDSKSSPGQSNLNVEVLVKLERKLQMNSVETRAQVVRELVQSERRYVQMLRIVQDVYAKPLRAALSSNRAILSAANIHIIFSDILHILNLNREFLDNLRDRLQEWSPAHCVGEIFIKFGSQLNIYTNFFNNYPVVLKTIEKCREMTPAFRAFLKRHDKTIVTKMLSLPELLIYPSRRFEEYIHLLYALRLHTPAGHVDRGDLTTAIDQVKKYKGYIDQIKENLKMREQLSDVQTLICGCPTLSEANRYLIRTQDVVQLHCCDEKMDFSLRLYEQIRDLSLLLFNDVLLVSSRSTSHTPFEKTSKTTYQFTASVALPRLLIEDIPDSKYIKNAFILRGSKREWICATEVSDDKFLWLSVLQHAIRSSMK", "length": 911, "header": "tr|F7CKP4-1|F7CKP4_MOUSE Computationally mapped isoform of Epithelial cell-transforming sequence 2 oncogene-like OS=Mus musculus OX=10090 GN=Ect2l PE=1 SV=2 CANONICAL=A0A140LIP2-1" }, "locus": { "chromosome": "10", "start_pos": 18077101, "end_pos": 18004773, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000095817.5", "url": "https://www.ensembl.org/id/ENSMUST00000095817.5" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000093497.5", "url": "https://www.ensembl.org/id/ENSMUSP00000093497.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "mmu:100045792", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:100045792", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q008S8-1", "protein_name": "Epithelial cell-transforming sequence 2 oncogene-like", "gene_name": "ECT2L", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MESFHTRFSAWTPFSNKSLNRQLFQERVALISHWFDLWTNKQRQEFLFAIFLRCTKSQLRFVQDWFSERMQVAKVDFSTVLPRFISLYIFSFLSPKDLCAAAQVSWPWKFLTEQDCLWMPKCVKFGWFLPYTPTDNEYGAWKRHYIACVSHLDWLTPREAAATYGTLNEPKTEDEELLERQREKCLRKRIWEKIALRKKELFKVRPPWVSGTCCSSVLKPRCQPRLSQTVRERVGLHEALEKQLVLTSLETLPKRSNISGSHSYPLLSKKNWHGVHKNDDRSSYALRPHFMLISSRIPAYEMVMESVKAGVVSVVYEHSVTLESLLYLIEKALDGQKAQSIGIFSDGDSREINLLQGYKIGVKNLLRPEVRDFWEKLGSYVATEEEGGHVDFFVPLGASEAGIEVLSQLSQLTGTFFTAPTGIATGSYQHILSDWLGSQWGKAPSSIYFCESKLQTWSSFTDFLEETLKTVRKQLYPFFKELQKSISGRMIGQFMFDTMGMTNILNNQDTAQALADGLMELSKEDSERNVVEDNSWDTKSRLSKNDLNFEALINLERILQKDSAEKRARVVRELLQSERKYVQILEIVRDVYVAPLKAALSSNRAILSAANIQIIFCDILQILSLNRQFLDNLRDRLQEWGPAHCVGEIVTKFGSQLNTYTNFFNNYPVILKTIEKCREMIPAFRTFLKRHDKTIVTKMLSLPELLLYPSRRFEEYLNLLYAVRLHTPAEHVDRGDLTTAIDQIKKYKGYIDQMKQNITMKDHLSDIQRIIWGCPTLSEVNRYLIRVQDVAQLHCCDEEISFSLRLYEHIHDLSLFLFNDALLVSSRGTSHTPFERTSKTTYQFIASVALHRLLIENIPDSKYVKNAFILQGPKYKWICATEIEDDKFLWLSVLRNAIKSSMEK", "length": 904 }, "evidence": [ { "id": "41493318", "url": "http://www.informatics.jax.org/homology/41493318", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "A0A140LIP2", "url": "https://www.uniprot.org/uniprot/A0A140LIP2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 269, "end_pos": 271, "annotation": "n_glycosylation_sequon" }, { "start_pos": 28, "end_pos": 30, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ] }