{ "uniprot_canonical_ac": "A0A0G2K2L2-1", "uniprot_ac": "A0A0G2K2L2", "uniprot_id": "A0A0G2K2L2_RAT", "mass": { "chemical_mass": 26284.0, "monoisotopic_mass": 26284.0 }, "refseq": { "ac": "XP_017446059", "name": "transmembrane and immunoglobulin domain containing 3 isoform X2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017446059" }, "gene_names": [ { "name": "Tmigd3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A0G2K2L2", "id": "A0A0G2K2L2" }, { "name": "Adora3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0G2K2L2", "id": "A0A0G2K2L2" }, { "name": "LOC100363178", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0G2K2L2", "id": "A0A0G2K2L2" }, { "name": "LOC100365814", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0G2K2L2", "id": "A0A0G2K2L2" }, { "name": "Tmigd3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289678", "id": "NP_001289678" } ], "protein_names": [ { "name": "Transmembrane and immunoglobulin domain-containing 3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A0G2K2L2#names_and_taxonomy", "id": "A0A0G2K2L2" }, { "name": "transmembrane and immunoglobulin domain containing 3 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289678", "id": "NP_001289678" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2L2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2L2" } ], "common_name": "Rat" } ], "gene": [ { "name": "Tmigd3", "url": "https://www.uniprot.org/uniprot/A0A0G2K2L2", "locus": { "chromosome": "2", "start_pos": 208323882, "end_pos": 208557356, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000043375", "url": "https://www.ensembl.org/id/ENSRNOG00000043375" } ] } } ], "crossref": [ { "id": "ENSRNOG00000043375", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000043375", "database": "Bgee" }, { "id": "100363178", "url": "https://www.ncbi.nlm.nih.gov/gene/100363178", "database": "GeneID" }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro" }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro" }, { "id": "rno:100363178", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:100363178", "database": "KEGG Pathway" }, { "id": "VHFLPVM", "url": "https://omabrowser.org/oma/group/VHFLPVM/", "database": "OMA" }, { "id": "NP_001289678", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289678", "database": "RefSeq" }, { "id": "XP_017446059", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017446059", "database": "RefSeq" }, { "id": "2324712", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=2324712", "database": "RGD" }, { "id": "A0A0G2K2L2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2L2", "database": "UniProtKB" }, { "id": "A0A0G2K2L2-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K2L2-1", "database": "UniProtKB" }, { "id": "F7FB47", "url": "https://www.uniprot.org/uniprot/F7FB47", "database": "UniProtKB" }, { "id": "F7FB47-1", "url": "https://www.uniprot.org/uniprot/F7FB47-1", "database": "UniProtKB" }, { "id": "Q4V8H0", "url": "https://www.uniprot.org/uniprot/Q4V8H0", "database": "UniProtKB" }, { "id": "Q4V8H0-1", "url": "https://www.uniprot.org/uniprot/Q4V8H0-1", "database": "UniProtKB" } ], "sequence": { "sequence": "IDPILKTKTKTRKDTYIDAMVMDEKVKSGVELDTASAICNYDAHYKDHTKYWCRGYFRDSCNIIAFTPNSSNRVALKDTGDQLIITVSCLVKEDTGWYWCGIQRDFARDDMDFTKLIVTDNREDRANGLSPGTSGNRTRSCKTSKAVQKAEGSRMSILIVCVLISGLGIIFLISHMSRGRRSQRNRGVTGKSINRNPQASQAPSMVSIPLTVLPKVPRQNGQQKALQWTGNATKTG", "length": 236, "header": "tr|A0A0G2K2L2-1|A0A0G2K2L2_RAT Isoform 1 of Transmembrane and immunoglobulin domain-containing 3 OS=Rattus norvegicus OX=10116 GN=Tmigd3 PE=4 SV=1 CANONICAL=A0A0G2K2L2-1" }, "isoforms": [ { "isoform_ac": "A0A0G2K2L2-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K2L2#A0A0G2K2L2-1", "sequence": { "sequence": "IDPILKTKTKTRKDTYIDAMVMDEKVKSGVELDTASAICNYDAHYKDHTKYWCRGYFRDSCNIIAFTPNSSNRVALKDTGDQLIITVSCLVKEDTGWYWCGIQRDFARDDMDFTKLIVTDNREDRANGLSPGTSGNRTRSCKTSKAVQKAEGSRMSILIVCVLISGLGIIFLISHMSRGRRSQRNRGVTGKSINRNPQASQAPSMVSIPLTVLPKVPRQNGQQKALQWTGNATKTG", "length": 236, "header": "tr|A0A0G2K2L2-1|A0A0G2K2L2_RAT Isoform 1 of Transmembrane and immunoglobulin domain-containing 3 OS=Rattus norvegicus OX=10116 GN=Tmigd3 PE=4 SV=1 CANONICAL=A0A0G2K2L2-1" }, "locus": { "chromosome": "2", "start_pos": 193414721, "end_pos": 193400082, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000085178.2", "url": "https://www.ensembl.org/id/ENSRNOT00000085178.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000072287.2", "url": "https://www.ensembl.org/id/ENSRNOP00000072287.2" } ] } }, { "isoform_ac": "F7FB47-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K2L2#F7FB47-1", "sequence": { "sequence": "MEPLLLLSLALFSDAMVMDEKVKSGVELDTASAICNYDAHYKDHTKYWCRGYFRDSCNIIAFTPNSSNRVALKDTGDQLIITVSCLVKEDTGWYWCGIQRDFARDDMDFTKLIVTDNREDRANGLSPGTSGNRTRSCKTSKAVQKAEGSRMSILIVCVLISGLGIIFLISHMSRGRRSQRNRGVTGKSINRNPQASQAPSMVSIPL", "length": 206, "header": "tr|F7FB47-1|F7FB47_RAT Computationally mapped isoform of Transmembrane and immunoglobulin domain-containing 3 OS=Rattus norvegicus OX=10116 GN=Tmigd3 PE=4 SV=1 CANONICAL=A0A0G2K2L2-1" }, "locus": { "chromosome": "2", "start_pos": 193408660, "end_pos": 193399213, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000021288.7", "url": "https://www.ensembl.org/id/ENSRNOT00000021288.7" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000021288.5", "url": "https://www.ensembl.org/id/ENSRNOP00000021288.5" } ] } }, { "isoform_ac": "Q4V8H0-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K2L2#Q4V8H0-1", "sequence": { "sequence": "MEPLLLLSLALFSDAMVMDEKVKSGVELDTASAICNYDAHYKDHTKYWCRGYFRDSCNIIAFTPNSSNRVALKDTGDQLIITVSCLVKEDTGWYWCGIQRDFARDDMDFTKLIVTDNREDRANGLSPGTSGNRTRSCKTSKAVQKAEGSRMSILIVCVLISGLGIIFLISHMSRGRRSQRNRGVTGKSINRNPQASQAPSMVSIPLTVLPKVPRQNGQQKALQWTGNATKTG", "length": 232, "header": "tr|Q4V8H0-1|Q4V8H0_RAT Computationally mapped isoform of Adora3 protein OS=Rattus norvegicus OX=10116 GN=Tmigd3 PE=2 SV=1 CANONICAL=A0A0G2K2L2-1" }, "locus": { "chromosome": "2", "start_pos": 193414721, "end_pos": 193399213, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000075939.3", "url": "https://www.ensembl.org/id/ENSRNOT00000075939.3" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000068169.1", "url": "https://www.ensembl.org/id/ENSRNOP00000068169.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "rno:100363178", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:100363178", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "G3X8R9-1", "protein_name": "Transmembrane domain-containing protein TMIGD3", "gene_name": "Tmigd3", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEFLLLLSLALFSDAMVMDEKVKSGVELETASAVCVYDAYYKDHTKYWCRGYFRDSCNIIAFTPNSTNRVALKDTGNQLIITISCLVKEDTGWYWCGIQRDLARDDMDFTQLIVTDNREDRANGFSSDPSGNRTRSCRASKAVQKAEGSRMSILIICILITSLGIIFIISHLSRGRRSQRNREVTGKSISRNPQASQGPSMVSITLARI", "length": 209 }, "evidence": [ { "id": "41506113", "url": "http://www.informatics.jax.org/homology/41506113", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P0DMS9-1", "protein_name": "Transmembrane domain-containing protein TMIGD3", "gene_name": "TMIGD3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEGSPAGPIEQKEARWESSWEEQPDWTLGCLSPESQFRIPGLPGCILSFQLKVCFLPVMWLFILLSLALISDAMVMDEKVKRSFVLDTASAICNYNAHYKNHPKYWCRGYFRDYCNIIAFSPNSTNHVALRDTGNQLIVTMSCLTKEDTGWYWCGIQRDFARDDMDFTELIVTDDKGTLANDFWSGKDLSGNKTRSCKAPKVVRKADRSRTSILIICILITGLGIISVISHLTKRRRSQRNRRVGNTLKPFSRVLTPKEMAPTEQM", "length": 266 }, "evidence": [ { "id": "41506113", "url": "http://www.informatics.jax.org/homology/41506113", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "transmembrane signaling receptor activity", "id": "GO:0004888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004888", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2L2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2L2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2L2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2L2" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2L2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2L2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "negative regulation of cell population proliferation", "id": "GO:0008285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2L2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2L2" } ], "pmid": "" }, { "name": "negative regulation of cell migration", "id": "GO:0030336", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030336", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2L2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2L2" } ], "pmid": "" }, { "name": "negative regulation of NF-kappaB transcription factor activity", "id": "GO:0032088", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032088", "evidence": [ { "database": "UniProtKB", "id": "A0A0G2K2L2", "url": "https://www.uniprot.org/uniprot/A0A0G2K2L2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 136, "end_pos": 138, "annotation": "n_glycosylation_sequon" }, { "start_pos": 231, "end_pos": 233, "annotation": "n_glycosylation_sequon" }, { "start_pos": 69, "end_pos": 71, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ] }