{ "uniprot_canonical_ac": "A0A096LP49-1", "uniprot_ac": "A0A096LP49", "uniprot_id": "CC187_HUMAN", "mass": { "chemical_mass": 114856.0, "monoisotopic_mass": 114856.0 }, "refseq": { "ac": "NP_001278445", "name": "coiled-coil domain-containing protein 187 isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278445" }, "gene_names": [ { "name": "CCDC187", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A096LP49", "id": "A0A096LP49" }, { "name": "CCDC187", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278445", "id": "NP_001278445" } ], "protein_names": [ { "name": "Coiled-coil domain-containing protein 187", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A096LP49#names_and_taxonomy", "id": "A0A096LP49" }, { "name": "coiled-coil domain-containing protein 187 isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278445", "id": "NP_001278445" }, { "name": "coiled-coil domain-containing protein 187", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278445", "id": "NP_001278445" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "47.96", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000260220", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000260220" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "55.83", "present": "ABSENT", "evidence": [ { "database": "Bgee", "id": "ENSG00000260220", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000260220" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "60.58", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000260220", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000260220" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "43.61", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000260220", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000260220" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "47.82", "present": "ABSENT", "evidence": [ { "database": "Bgee", "id": "ENSG00000260220", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000260220" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "51.55", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000260220", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000260220" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "73.32", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000260220", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000260220" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "32.47", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000260220", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000260220" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "38.94", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000260220", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000260220" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "36.94", "present": "ABSENT", "evidence": [ { "database": "Bgee", "id": "ENSG00000260220", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000260220" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "A0A096LP49", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0A096LP49" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostate cancer", "description": "A primary or metastatic malignant tumor involving the prostate gland. The vast majority are carcinomas." }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant tumor of prostate", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant neoplasm of prostate", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant neoplasm of prostate gland", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant prostate tumor", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant neoplasm of the prostate", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostate neoplasm", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostate gland cancer", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant prostate neoplasm", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostatic cancer", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant tumor of the prostate", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "prostatic neoplasm", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "malignant prostate gland neoplasm", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "cancer of prostate gland", "description": "" }, { "id": "MONDO:0008315", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008315", "name": "NGP - new growth of prostate", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, 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"malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": 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"MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "No", "trend": "down", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "A0A096LP49", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0A096LP49" } ], "disease": [ { "disease_id": "DOID:11054", 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"https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0007254", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007254", "name": "breast cancer", "description": "A primary or metastatic malignant neoplasm involving the breast. 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"Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Thyroid gland cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "A0A096LP49", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0A096LP49" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "Thyroid gland neoplasm", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant tumour of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid neoplasm", "description": "" } ] } ] }, { "significant": "No", "trend": "down", "name": "Kidney cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:263", "evidence": [ { "database": "BioXpress", "id": "A0A096LP49", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0A096LP49" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "A0A096LP49", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0A096LP49" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": 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"https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Colorectal cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:9256", "evidence": [ { "database": "BioXpress", "id": "A0A096LP49", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A0A096LP49" } ], "disease": [ { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", 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"sp|A0A096LP49-2|CC187_HUMAN Isoform 2 of Coiled-coil domain-containing protein 187 OS=Homo sapiens OX=9606 GN=CCDC187 PE=2 SV=1 CANONICAL=A0A096LP49-1" }, "locus": { "chromosome": "9", "start_pos": 136303142, "end_pos": 136281402, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000569961.5", "url": "https://www.ensembl.org/id/ENST00000569961.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000456543.1", "url": "https://www.ensembl.org/id/ENSP00000456543.1" } ] } }, { "isoform_ac": "A0A1W2PQX5-1", "url": "https://www.uniprot.org/uniprot/A0A096LP49#A0A1W2PQX5-1", "sequence": { "sequence": 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"length": 2077, "header": "tr|A0A1W2PQX5-1|CC187_HUMAN Computationally mapped isoform of Coiled-coil domain-containing protein 187 OS=Homo sapiens OX=9606 GN=CCDC187 PE=2 SV=1 CANONICAL=A0A096LP49-1" }, "locus": { "chromosome": "9", "start_pos": 136303830, "end_pos": 136253597, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000638797.2", "url": "https://www.ensembl.org/id/ENST00000638797.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000492326.1", "url": "https://www.ensembl.org/id/ENSP00000492326.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Functional role for the class IX myosin myr5 in epithelial cell infection by Shigella flexneri.", "journal": "Cellular microbiology", "date": "2000", "authors": "Graf B, Bahler M, Hilpela P, Bowe C, Adam T", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013106", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013106" } ], "reference": [ { "type": "PubMed", "id": "11207612", "url": "https://glygen.org/publication/PubMed/11207612" } ] }, { "title": "XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Arthur WT, Ellerbroek SM, Der CJ, Burridge K, Wennerberg K", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013106", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013106" } ], "reference": [ { "type": "PubMed", "id": "12221096", "url": "https://glygen.org/publication/PubMed/12221096" } ] }, { "title": "Scambio, a novel guanine nucleotide exchange factor for Rho.", "journal": "Molecular cancer", "date": "2004", "authors": "Curtis C, Hemmeryckx B, Haataja L, Senadheera D, Groffen J, Heisterkamp N", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013106", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013106" } ], "reference": [ { "type": "PubMed", "id": "15107133", "url": "https://glygen.org/publication/PubMed/15107133" } ] }, { "title": "GrinchGEF--a novel Rho-specific guanine nucleotide exchange factor.", "journal": "Biochemical and biophysical research communications", "date": "2005", "authors": "Winkler S, Mohl M, Wieland T, Lutz S", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013106", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013106" } ], "reference": [ { "type": "PubMed", "id": "16112081", "url": "https://glygen.org/publication/PubMed/16112081" } ] }, { "title": "Inactivation of Rho GTPases by p190 RhoGAP reduces human pancreatic cancer cell invasion and metastasis.", "journal": "Cancer science", "date": "2006", "authors": "Kusama T, Mukai M, Endo H, Ishikawa O, Tatsuta M, Nakamura H, Inoue M", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013106", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013106" } ], "reference": [ { "type": "PubMed", "id": "16776779", "url": "https://glygen.org/publication/PubMed/16776779" } ] }, { "title": "The effect of missense mutations in the RhoGAP-homology domain on ocrl1 function.", "journal": "Molecular genetics and metabolism", "date": "2006", "authors": "Lichter-Konecki U, Farber LW, Cronin JS, Suchy SF, Nussbaum RL", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013106", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013106" } ], "reference": [ { "type": "PubMed", "id": "16777452", "url": "https://glygen.org/publication/PubMed/16777452" } ] }, { "title": "Gef10--the third member of a Rho-specific guanine nucleotide exchange factor subfamily with unusual protein architecture.", "journal": "Naunyn-Schmiedeberg's archives of pharmacology", "date": "2006", "authors": "Mohl M, Winkler S, Wieland T, Lutz S", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013106", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013106" } ], "reference": [ { "type": "PubMed", "id": "16896804", "url": "https://glygen.org/publication/PubMed/16896804" } ] }, { "title": "ARAP2 effects on the actin cytoskeleton are dependent on Arf6-specific GTPase-activating-protein activity and binding to RhoA-GTP.", "journal": "Journal of cell science", "date": "2006", "authors": "Yoon HY, Miura K, Cuthbert EJ, Davis KK, Ahvazi B, Casanova JE, Randazzo PA", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013106", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013106" } ], "reference": [ { "type": "PubMed", "id": "17077126", "url": "https://glygen.org/publication/PubMed/17077126" } ] }, { "title": "A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathway.", "journal": "Developmental cell", "date": "2007", "authors": "Erdmann KS, Mao Y, McCrea HJ, Zoncu R, Lee S, Paradise S, Modregger J, Biemesderfer D, Toomre D, De Camilli P", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013106", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013106" } ], "reference": [ { "type": "PubMed", "id": "17765681", "url": "https://glygen.org/publication/PubMed/17765681" } ] }, { "title": "DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms.", "journal": "Molecular carcinogenesis", "date": "2008", "authors": "Healy KD, Hodgson L, Kim TY, Shutes A, Maddileti S, Juliano RL, Hahn KM, Harden TK, Bang YJ, Der CJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013106", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013106" } ], "reference": [ { "type": "PubMed", "id": "17932950", "url": "https://glygen.org/publication/PubMed/17932950" } ] }, { "title": "Biochemical characterization of the Rho GTPase-regulated actin assembly by diaphanous-related formins, mDia1 and Daam1, in platelets.", "journal": "The Journal of biological chemistry", "date": "2008", "authors": "Higashi T, Ikeda T, Shirakawa R, Kondo H, Kawato M, Horiguchi M, Okuda T, Okawa K, Fukai S, Nureki O, Kita T, Horiuchi H", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013106", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013106" } ], "reference": [ { "type": "PubMed", "id": "18218625", "url": "https://glygen.org/publication/PubMed/18218625" } ] }, { "title": "Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5.", "journal": "The Journal of biological chemistry", "date": "2009", "authors": "Wang Z, Kumamoto Y, Wang P, Gan X, Lehmann D, Smrcka AV, Cohn L, Iwasaki A, Li L, Wu D", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013106", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013106" } ], "reference": [ { "type": "PubMed", "id": "19713215", "url": "https://glygen.org/publication/PubMed/19713215" } ] }, { "title": "Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC.", "journal": "Oncogene", "date": "2010", "authors": "Kitzing TM, Wang Y, Pertz O, Copeland JW, Grosse R", "evidence": [ { 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of biological chemistry", "date": "2011", "authors": "Jaiswal M, Gremer L, Dvorsky R, Haeusler LC, Cirstea IC, Uhlenbrock K, Ahmadian MR", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013106", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013106" } ], "reference": [ { "type": "PubMed", "id": "21454492", "url": "https://glygen.org/publication/PubMed/21454492" } ] }, { "title": "RhoA and RhoC have distinct roles in migration and invasion by acting through different targets.", "journal": "The Journal of cell biology", "date": "2011", "authors": "Vega FM, Fruhwirth G, Ng T, Ridley AJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013106", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013106" } ], "reference": [ { "type": "PubMed", "id": "21576392", "url": "https://glygen.org/publication/PubMed/21576392" } ] }, { "title": "RhoGDIalpha-dependent balance between RhoA and RhoC is a key regulator of cancer cell tumorigenesis.", "journal": "Molecular biology of the cell", "date": "2011", "authors": "Giang Ho TT, Stultiens A, Dubail J, Lapiere CM, Nusgens BV, Colige AC, Deroanne CF", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013106", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013106" } ], "reference": [ { "type": "PubMed", "id": "21757538", "url": "https://glygen.org/publication/PubMed/21757538" } ] }, { "title": "Divergence of Rho residue 43 impacts GEF activity.", "journal": "Small GTPases", "date": "2012", "authors": "Sloan CM, Quinn CV, Peters JP, Farley J, Goetzinger C, Wernli M, DeMali KA, Ellerbroek SM", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013106", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013106" } ], "reference": [ { "type": "PubMed", "id": "22673745", "url": "https://glygen.org/publication/PubMed/22673745" } ] }, { "title": "Protein N-myristoylation is required for cellular morphological changes induced by two formin family proteins, FMNL2 and FMNL3.", "journal": "Bioscience, biotechnology, and biochemistry", "date": "2012", "authors": "Moriya K, Yamamoto T, Takamitsu E, Matsunaga Y, Kimoto M, Fukushige D, Kimoto C, Suzuki T, Utsumi T", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013106", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013106" } ], "reference": [ { "type": "PubMed", "id": "22790947", "url": "https://glygen.org/publication/PubMed/22790947" } ] }, { "title": "Identification of a novel actin-binding domain within the Rho guanine nucleotide exchange factor TEM4.", "journal": "PloS one", "date": "2012", "authors": "Mitin N, Rossman KL, Der CJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013106", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013106" } ], "reference": [ { "type": "PubMed", "id": "22911862", "url": "https://glygen.org/publication/PubMed/22911862" } ] }, { "title": "Rho isoform-specific interaction with IQGAP1 promotes breast cancer cell proliferation and migration.", "journal": "The Journal of biological chemistry", "date": "2012", "authors": "Casteel DE, Turner S, Schwappacher R, Rangaswami H, Su-Yuo J, Zhuang S, Boss GR, Pilz RB", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013106", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013106" } ], "reference": [ { "type": "PubMed", "id": "22992742", "url": "https://glygen.org/publication/PubMed/22992742" } ] }, { "title": "ARHGAP21 is a RhoGAP for RhoA and RhoC with a role in proliferation and migration of prostate adenocarcinoma cells.", "journal": "Biochimica et biophysica acta", "date": "2013", "authors": "Lazarini M, Traina F, Machado-Neto JA, Barcellos KS, Moreira YB, Brandao MM, Verjovski-Almeida S, Ridley AJ, Saad ST", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013106", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013106" } ], "reference": [ { "type": "PubMed", "id": "23200924", "url": "https://glygen.org/publication/PubMed/23200924" } ] }, { "title": "Deciphering the molecular and functional basis of Dbl family proteins: a novel systematic approach toward classification of selective activation of the Rho family proteins.", "journal": "The Journal of biological chemistry", "date": "2013", "authors": "Jaiswal M, Dvorsky R, Ahmadian MR", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013106", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013106" } ], "reference": [ { "type": "PubMed", "id": "23255595", "url": "https://glygen.org/publication/PubMed/23255595" } ] }, { "title": "Differential binding of RhoA, RhoB, and RhoC to protein kinase C-related kinase (PRK) isoforms PRK1, PRK2, and PRK3: PRKs have the highest affinity for RhoB.", "journal": "Biochemistry", "date": "2013", "authors": "Hutchinson CL, Lowe PN, McLaughlin SH, Mott HR, Owen D", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013106", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013106" } ], "reference": [ { "type": "PubMed", "id": "24128008", "url": "https://glygen.org/publication/PubMed/24128008" } ] }, { "title": "ARHGAP18: an endogenous inhibitor of angiogenesis, limiting tip formation and stabilizing junctions.", "journal": "Small GTPases", "date": "2014", "authors": "Chang GH, Lay AJ, Ting KK, Zhao Y, Coleman PR, Powter EE, Formaz-Preston A, Jolly CJ, Bower NI, Hogan BM, Rinkwitz S, Becker TS, Vadas MA, Gamble JR", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013106", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013106" } ], "reference": [ { "type": "PubMed", "id": "25425145", "url": "https://glygen.org/publication/PubMed/25425145" } ] }, { "title": "Deciphering the Molecular and Functional Basis of RHOGAP Family Proteins: A SYSTEMATIC APPROACH TOWARD SELECTIVE INACTIVATION OF RHO FAMILY PROTEINS.", "journal": "The Journal of biological chemistry", "date": "2016", "authors": "Amin E, Jaiswal M, Derewenda U, Reis K, Nouri K, Koessmeier KT, Aspenstrom P, Somlyo AV, Dvorsky R, Ahmadian MR", "evidence": [ { 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the cytoskeleton.", "journal": "Molecular and cellular biology", "date": "1996", "authors": "Leung T, Chen XQ, Manser E, Lim L", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013106", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013106" } ], "reference": [ { "type": "PubMed", "id": "8816443", "url": "https://glygen.org/publication/PubMed/8816443" } ] }, { "title": "RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG.", "journal": "The Journal of biological chemistry", "date": "1996", "authors": "Zalcman G, Closson V, Camonis J, Honore N, Rousseau-Merck MF, Tavitian A, Olofsson B", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013106", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013106" } ], "reference": [ { "type": "PubMed", "id": "8939998", "url": "https://glygen.org/publication/PubMed/8939998" } ] }, { "title": "Citron rho-interacting kinase, a novel tissue-specific ser/thr kinase encompassing the Rho-Rac-binding protein Citron.", "journal": "The Journal of biological chemistry", "date": "1998", "authors": "Di Cunto F, Calautti E, Hsiao J, Ong L, Topley G, Turco E, Dotto GP", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013106", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013106" } ], "reference": [ { "type": "PubMed", "id": "9792683", "url": 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"length": 2090 }, "evidence": [ { "id": "41502733", "url": "http://www.informatics.jax.org/homology/41502733", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8C5V8-1", "protein_name": "Coiled-coil domain-containing protein 187", "gene_name": "Ccdc187", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": 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