{
    "bcoid": "GLY_000319",
    "title": "Mouse Protein Reactions (Reactome)",
    "description": "The Mouse Protein Reactions (Reactome) dataset contains reactions information for pathways for mouse ...",
    "filename": "mouse_protein_reactions_reactome.csv",
    "filetype": "csv",
    "categories": {
        "species": "Mus musculus",
        "molecule": "Protein",
        "tags": "Reactions Reactome",
        "file_type": "csv",
        "status": "Reviewed",
        "scope": "internal"
    },
    "minitable": {
        "content": [
            [
                "R-MMU-163214...",
                "Electron tra..."
            ],
            [
                "R-MMU-961590...",
                "AHCTF1 (ELYS..."
            ]
        ],
        "headers": [
            "reaction_id...",
            "reaction_nam..."
        ],
        "colwidth": [
            "40%",
            "20%"
        ]
    },
    "sampledata": {
        "type": "table",
        "data": [
            [
                {
                    "type": "string",
                    "label": "reaction_id"
                },
                {
                    "type": "string",
                    "label": "reaction_name"
                },
                {
                    "type": "string",
                    "label": "cellular_location"
                },
                {
                    "type": "string",
                    "label": "pmid"
                },
                {
                    "type": "string",
                    "label": "pathway_id"
                },
                {
                    "type": "string",
                    "label": "equation"
                },
                {
                    "type": "string",
                    "label": "reaction_summary"
                }
            ],
            [
                "R-MMU-163214",
                "Electron transfer from reduced cytochrome c to molecular oxygen",
                "mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrial matrix",
                "",
                "R-MMU-5628897",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9615901",
                "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex",
                "cytosol",
                "",
                "R-MMU-9615933",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9618378",
                "POM121 binds the Nup107-Nup160 complex",
                "cytosol, nuclear envelope",
                "",
                "R-MMU-9615933",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9664855",
                "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1",
                "peroxisomal membrane",
                "",
                "R-MMU-9664873",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9664880",
                "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1",
                "peroxisomal membrane",
                "",
                "R-MMU-9664873",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9664881",
                "NBR1 binds ATM:Ub-p-PEX5:SQSTM1",
                "peroxisomal membrane",
                "",
                "R-MMU-9664873",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9664892",
                "SQSTM1 binds ATM dimer:Ub-p-PEX5",
                "cytosol, peroxisomal membrane",
                "",
                "R-MMU-9664873",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9674127",
                "USP30 deubiquitinates ATM dimer:Ub-p-PEX5",
                "peroxisomal membrane",
                "",
                "R-MMU-9664873",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9674131",
                "USP30 binds ATM dimer:Ub-p-PEX5",
                "peroxisomal membrane",
                "",
                "R-MMU-9664873",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9678935",
                "IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors",
                "cytosol, plasma membrane",
                "",
                "R-MMU-909733",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9679740",
                "ITGA4:ITGB1 binds natalizumab",
                "extracellular region, plasma membrane",
                "",
                "R-MMU-198933",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9013533",
                "MPST transfers sulfur from sulfanegen to HCN to form HSCN",
                "mitochondrial matrix",
                "",
                "R-MMU-1614558",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9647977",
                "ICMT methylates S-Farn RAS proteins",
                "endoplasmic reticulum membrane",
                "",
                "R-MMU-9648002",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9647978",
                "pro-RAS proteins are farnesylated",
                "cytosol, endoplasmic reticulum membrane",
                "",
                "R-MMU-9648002",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9647980",
                "mature RAS proteins translocate to plasma membrane",
                "Golgi membrane, plasma membrane",
                "",
                "R-MMU-9648002",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9647982",
                "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated",
                "Golgi membrane, endoplasmic reticulum membrane",
                "",
                "R-MMU-9648002",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9647994",
                "RAS proteins are depalmitoylated",
                "plasma membrane",
                "",
                "R-MMU-9648002",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9647999",
                "RCE1 cleaves S-Farn proRAS proteins",
                "endoplasmic reticulum membrane",
                "",
                "R-MMU-9648002",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9649733",
                "mature p21 RAS binds GDP",
                "plasma membrane",
                "",
                "R-MMU-9648002",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9649735",
                "Intrinsic nucleotide exchange on RAS",
                "cytosol, plasma membrane",
                "",
                "R-MMU-5673001",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9649736",
                "RAS intrinsic GTPase activity hydrolyzes GTP to GDP",
                "plasma membrane",
                "",
                "R-MMU-5673001",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9660557",
                "RAS:GTP binds RAL GDS proteins",
                "cytosol, plasma membrane",
                "",
                "R-MMU-5673001",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9667952",
                "ANKLE2 is deacetylated by SIRT2",
                "cytosol, endoplasmic reticulum membrane",
                "",
                "R-MMU-2995383",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9667965",
                "ANKLE2 binds PP2A",
                "cytosol, endoplasmic reticulum membrane",
                "",
                "R-MMU-2995383",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9668405",
                "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin",
                "cytosol, nuclear envelope",
                "",
                "R-MMU-9668328",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9679028",
                "JAK3 binds JAK3 inhibitors",
                "cytosol",
                "",
                "R-MMU-1266695",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9679029",
                "C-ter TLR7 dimer binds HCQ",
                "cytosol, endosome membrane",
                "",
                "R-MMU-168181",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-114256",
                "CYCS:APAF1 binds procaspase-9",
                "cytosol",
                "",
                "R-MMU-111458",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-6797630",
                "LRPP4(LRPP1-3,5) hydrolyse LPA",
                "extracellular region, plasma membrane",
                "",
                "R-MMU-419408",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-6804596",
                "APAF1:CYCS binds APIP",
                "cytosol",
                "",
                "R-MMU-9627069",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9681763",
                "IL1R1 binds IL1R1 inhibitors",
                "extracellular region, plasma membrane",
                "",
                "R-MMU-9020702",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-114254",
                "CYCS binds to APAF1",
                "cytosol",
                "",
                "R-MMU-111458",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-3341294",
                "Superoxide reduces cytochrome c",
                "mitochondrial inner membrane, mitochondrial intermembrane space",
                "",
                "R-MMU-3299685",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9015111",
                "Factor Xa inhibitors binds Xa",
                "extracellular region, plasma membrane",
                "",
                "R-MMU-140875",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9670673",
                "FIX is secreted",
                "endoplasmic reticulum lumen, extracellular region",
                "",
                "R-MMU-140837",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9684627",
                "CYSLTR1 binds CYSLTR1 antagonists",
                "extracellular region, plasma membrane",
                "",
                "R-MMU-391906",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9690439",
                "CYSLTR1 binds LTC4,LTD4,LTE4",
                "extracellular region, plasma membrane",
                "",
                "R-MMU-391906",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9614271",
                "Autocleavage of ADGRG6",
                "endoplasmic reticulum membrane",
                "",
                "R-MMU-9619665",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9614273",
                "ADGRG heterodimer translocates to plasma membrane",
                "plasma membrane",
                "",
                "R-MMU-9619665",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9664850",
                "ATM binds PEX5",
                "cytosol",
                "",
                "R-MMU-9664873",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9664862",
                "ATM dimer:PEX5 phosphorylates PEX5",
                "peroxisomal membrane",
                "",
                "R-MMU-9664873",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9664879",
                "ATM:PEX5 binds ATM",
                "peroxisomal membrane",
                "",
                "R-MMU-9664873",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9664883",
                "ATM:PEX5 translocates from cytosol to peroxisomal membrane",
                "cytosol, peroxisomal membrane",
                "",
                "R-MMU-9664873",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9664888",
                "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5",
                "peroxisomal membrane",
                "",
                "R-MMU-9664873",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-70870",
                "ECHS1 hydrates methacrylyl-CoA",
                "mitochondrial matrix",
                "",
                "R-MMU-70895",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-8944257",
                "Association of procollagen type XXIV",
                "endoplasmic reticulum lumen",
                "",
                "R-MMU-8948216",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9679775",
                "COMT binds COMT Inhibitors",
                "extracellular region, plasma membrane",
                "",
                "R-MMU-379397",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9695949",
                "SPHK2 phosphorylates SPG to S1P",
                "cytosol, endoplasmic reticulum membrane",
                "",
                "R-MMU-1660661",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9620391",
                "Creb, Srf, and Mef2d bind the ARC gene",
                "nucleoplasm",
                "19116276",
                "",
                "",
                "Studies in mouse identified a Synaptic Activity Response Element (SARE) ~7kb upstream of the transcription start site that promotes ARC gene transcription under stimulatory synaptic conditions.  The SARE contains at least 3 conserved binding regions with consensus sites for Mef2d, Srf and Creb, and EMSA and ChIP confirm binding to these sites (Kawashima et al, 2009)."
            ],
            [
                "R-MMU-9673827",
                "Slc25a44 transports Leu, Ile and Val from cytosol to mitochondrial matrix",
                "mitochondrial inner membrane",
                "31435015",
                "",
                "",
                "Mitochondrial uptake of the three branched-chain amino acids leucine (Leu), isoleucine (Ile), and valine (Val) is mediated by solute carrier family 25 member 44 (Slc25a44), localized in the inner mitochondrial membrane, as demonstrated by studies of studies of knockout mice and of liposomes rconstituted with recombinant protein (Yoneshiro et al. 2019)."
            ],
            [
                "R-MMU-9023204",
                "Insulin secretory granules translocate across the cortical actin network",
                "cytosol",
                "15788565",
                "",
                "",
                "Insulin-containing secretory granules are bound to Myosin Va via Rab27a in a complex of uncertain composition. Mysosin Va moves along the cortical actin network (actin at the periphery of the cytoplasm), carrying the granules to the inner surface of the plasma membrane."
            ],
            [
                "R-MMU-9023204",
                "Insulin secretory granules translocate across the cortical actin network",
                "cytosol",
                " 17827149",
                "",
                "",
                "Insulin-containing secretory granules are bound to Myosin Va via Rab27a in a complex of uncertain composition. Mysosin Va moves along the cortical actin network (actin at the periphery of the cytoplasm), carrying the granules to the inner surface of the plasma membrane."
            ],
            [
                "R-MMU-9023204",
                "Insulin secretory granules translocate across the cortical actin network",
                "cytosol",
                " 16714477",
                "",
                "",
                "Insulin-containing secretory granules are bound to Myosin Va via Rab27a in a complex of uncertain composition. Mysosin Va moves along the cortical actin network (actin at the periphery of the cytoplasm), carrying the granules to the inner surface of the plasma membrane."
            ],
            [
                "R-MMU-9023204",
                "Insulin secretory granules translocate across the cortical actin network",
                "cytosol",
                " 11865063",
                "",
                "",
                "Insulin-containing secretory granules are bound to Myosin Va via Rab27a in a complex of uncertain composition. Mysosin Va moves along the cortical actin network (actin at the periphery of the cytoplasm), carrying the granules to the inner surface of the plasma membrane."
            ],
            [
                "R-MMU-9023204",
                "Insulin secretory granules translocate across the cortical actin network",
                "cytosol",
                " 15690086",
                "",
                "",
                "Insulin-containing secretory granules are bound to Myosin Va via Rab27a in a complex of uncertain composition. Mysosin Va moves along the cortical actin network (actin at the periphery of the cytoplasm), carrying the granules to the inner surface of the plasma membrane."
            ],
            [
                "R-MMU-9023204",
                "Insulin secretory granules translocate across the cortical actin network",
                "cytosol",
                " 18801842",
                "",
                "",
                "Insulin-containing secretory granules are bound to Myosin Va via Rab27a in a complex of uncertain composition. Mysosin Va moves along the cortical actin network (actin at the periphery of the cytoplasm), carrying the granules to the inner surface of the plasma membrane."
            ],
            [
                "R-MMU-9023204",
                "Insulin secretory granules translocate across the cortical actin network",
                "cytosol",
                " 22993210",
                "",
                "",
                "Insulin-containing secretory granules are bound to Myosin Va via Rab27a in a complex of uncertain composition. Mysosin Va moves along the cortical actin network (actin at the periphery of the cytoplasm), carrying the granules to the inner surface of the plasma membrane."
            ],
            [
                "R-MMU-9650165",
                "ASIC trimers bind H+",
                "extracellular region, plasma membrane",
                "",
                "R-MMU-2672351",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9647746",
                "EML4 trimerizes",
                "cytosol",
                "",
                "R-MMU-9648025",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-114252",
                "Cleavage of Procaspase-3 by the apoptosome",
                "cytosol",
                "",
                "R-MMU-111459",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-114261",
                "Cleavage of Procaspase-7 by the apoptosome",
                "cytosol",
                "",
                "R-MMU-111459",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-182594",
                "Association of INK4 family proteins with CDK4/6",
                "cytosol",
                "",
                "R-MMU-2559580",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-5675206",
                "PEA15 binds MAPK monomers and dimers",
                "cytosol",
                "",
                "R-MMU-5673001",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9613213",
                "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression",
                "nucleoplasm",
                "",
                "R-MMU-9031628",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9627078",
                "XIAP binds CASP9",
                "cytosol",
                "",
                "R-MMU-9627069",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9627089",
                "CASP9 is phosphorylated at T125",
                "cytosol",
                "",
                "R-MMU-9627069",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9635739",
                "PTPN7 dephosphorylates p-T,Y-MAPKs",
                "cytosol",
                "",
                "R-MMU-5675221",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9635743",
                "PTPN7 binds p-T,Y-MAPK",
                "cytosol",
                "",
                "R-MMU-5675221",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9652264",
                "ERBB2 binds TKIs",
                "cytosol, plasma membrane",
                "",
                "R-MMU-9652282",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9668597",
                "DNA polymerase:primase binds G-strand of the telomere",
                "nucleoplasm",
                "",
                "R-MMU-174430",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9668831",
                "CST complex formation",
                "nucleoplasm",
                "",
                "R-MMU-174430",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9674095",
                "PDGFRs bind type II TKI",
                "cytosol, plasma membrane",
                "",
                "R-MMU-186797",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9679477",
                "VEGFA-165 dimer binds VEGFA inhibitors",
                "extracellular region",
                "",
                "R-MMU-4420097",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9686521",
                "CDK2:CCNA phosphorylates TERF2",
                "nucleoplasm",
                "",
                "R-MMU-171319",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9686524",
                "PP6-PPP6R3 dephosphorylates TERF2",
                "nucleoplasm",
                "",
                "R-MMU-171319",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9686930",
                "RIPK3 is cleaved by CASP8",
                "plasma membrane",
                "",
                "R-MMU-5675482",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9691215",
                "VEGFA-165 dimer binds VEGFR2 dimer",
                "extracellular region, plasma membrane",
                "",
                "R-MMU-4420097",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9695890",
                "SPNS2 transports S1P from cytosol to extracellular region",
                "cytosol, extracellular region, plasma membrane",
                "",
                "R-MMU-1660661",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9734670",
                "ORC6 binds KPNA1 or KPNA6",
                "cytosol",
                "",
                "R-MMU-68616",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9734687",
                "ORC6 is phosphorylated on T195",
                "cytosol",
                "",
                "R-MMU-68616",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9734713",
                "ORC6 translocates to the nucleus",
                "cytosol, nucleoplasm",
                "",
                "R-MMU-68616",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9717214",
                "I(1,4,5)P3 binds ITPR3 tetramer",
                "endoplasmic reticulum membrane",
                "",
                "R-MMU-9717207",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9717215",
                "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol",
                "endoplasmic reticulum membrane",
                "",
                "R-MMU-9717207",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ],
            [
                "R-MMU-9737780",
                "MTTP binds lomitapide",
                "endoplasmic reticulum lumen",
                "",
                "R-MMU-8964041",
                "",
                "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>"
            ]
        ]
    },
    "readme": "Name\n   - Mouse Protein Reactions (Reactome)\n\nVersion\n   - v-2.0.3\n\nCreated on\n  - 2019-11-30T15:03:14.488331\n\nModified on\n   - 2022-09-26T09:05:27.774888\n\nCreated by\n   - Jeet Vora [jeetvora@gwu.edu], Rahi Navelkar [rsn13@gwu.edu], Robel Kahsay [rykahsay@gwu.edu], Xavier Holmes [xavierh@email.gwu.edu], Karina Martinez [karinamartinez@gwu.edu], Amanda Bell [amandab2140@gwu.edu], Jonathon Keeney [keeneyjg@gwu.edu], Millicent Quartey [mquartey@email.gwu.edu]\n\nAuthors\n   - Maria Martin [martin@ebi.ac.uk], Preethi Vasudev [pvasudev@ebi.ac.uk]\n\nChecksum\n   - \n\nUsability Domain\n   - The Mouse Protein Reactions (Reactome) dataset contains reactions information for pathways for mouse [taxid:10090] UniProtKB accessions that includes reaction participants, pathway ID, reaction ID, PMID etc from Reactome database. The dataset is derived from 2019-09 UniProtKB release. If you use this dataset please provide proper attribution to EMBL-EBI-UniProtKB and GlyGen\n\nDescription Domain\n   Keywords\n   - Reactome\n   - Pathway\n   - Reactions\n   - PMID\n\n   Pipeline Steps\n   - Step-1: The script loads the Reactome reaction data from the triplestore containing triples from nt file to retrieve the information associated with the Reactome IDs and maps it to the UniProtKB canonical accessions and extracts the dataset in the csv format\n\nExecution Domain\n   Scripts   - https://github.com/glygener/glygen-backend-integration/blob/master/dataset-maker/make-protein-dataset.py\n\n\n   Software Prerequisites\n      Name: Python\n      Version: 2.7.5\n      URI: https://www.python.org/download/releases/2.7.5/\n\nI/O Domain\n   Input Subdomain\n      Name: uniprot-proteome-mus-musculus.nt\n      URI: /data/shared/glyds/downloads/ebi/2022_05/uniprot-proteome-mus-musculus.nt\n   Output Subdomain\n      Name: mouse_protein_reactions_reactome.csv\n      URI: https:/data.glygen.org/ln2releases/data/v-2.0.3/reviewed/mouse_protein_reactions_reactome.csv\n      Name: mouse_protein_reactions_reactome.stat.csv\n      URI: https:/data.glygen.org/ln2releases/data/v-2.0.3/reviewed/mouse_protein_reactions_reactome.stat.csv\n\nFields\n      Name: \"reaction_id\"\n     Description: \"The identifier assigned to a reaction in Reactome database\"\n      Unique Values: \"9305\"\n      Name: \"reaction_name\"\n     Description: \"The name assigned to a reaction in Reactome database\"\n      Unique Values: \"9279\"\n      Name: \"cellular_location\"\n     Description: \"The loaction in the cell where reaction occurs\"\n      Unique Values: \"283\"\n      Name: \"pmid\"\n     Description: \"NCBI PubMed database Identifier\"\n      Unique Values: \"1790\"\n      Name: \"pathway_id\"\n     Description: \"Pathway Identifier\"\n      Unique Values: \"1333\"\n      Name: \"equation\"\n     Description: \"\"\n      Unique Values: \"1\"\n      Name: \"reaction_summary\"\n     Description: \"\"\n      Unique Values: \"1033\"",
    "downloadurl": "/ln2data/releases/data/v-2.0.3/reviewed/mouse_protein_reactions_reactome.csv"
}
