{
    "title": "Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin.",
    "journal": "Science",
    "date": "1999",
    "authors": "Suzuki A., Akiyama T., Hamada F., Toyoshima K., Takatsu Y., Nakamura M., Nagai S., Fujita F., Shibuya H., Ueno N., Tomoyasu Y.",
    "reference": {
        "type": "PubMed",
        "id": "10073940",
        "url": "https://pubmed.ncbi.nlm.nih.gov/10073940"
    },
    "referenced_proteins": [
        "Q9V407-1"
    ],
    "referenced_glycans": [],
    "species": [
        {
            "name": "Drosophila melanogaster",
            "taxid": 7227,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9V407",
                    "url": "https://www.uniprot.org/uniprot/Q9V407"
                }
            ],
            "common_name": "Fruit fly"
        }
    ],
    "record_id": "pubmed.10073940",
    "abstract": "Wnt/Wingless directs many cell fates during development. Wnt/Wingless signaling increases the amount of beta-catenin/Armadillo, which in turn activates gene transcription. Here the Drosophila protein D-Axin was shown to interact with Armadillo and D-APC. Mutation of d-axin resulted in the accumulation of cytoplasmic Armadillo and one of the Wingless target gene products, Distal-less. Ectopic expression of d-axin inhibited Wingless signaling. Hence, D-Axin negatively regulates Wingless signaling by down-regulating the level of Armadillo. These results establish the importance of the Axin family of proteins in Wnt/Wingless signaling in Drosophila.",
    "glycosylation": [],
    "mutagenesis": [],
    "snv": [],
    "phosphorylation": [],
    "glycation": []
}