{ "uniprot_canonical_ac": "A0A8I5ZRT2-1", "uniprot_ac": "A0A8I5ZRT2", "uniprot_id": "A0A8I5ZRT2_RAT", "mass": { "chemical_mass": 185369.0, "monoisotopic_mass": 185369.0 }, "refseq": { "ac": "NP_001102203", "name": "histone-lysine N-methyltransferase, H3 lysine-79 specific", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102203" }, "gene_names": [ { "name": "Dot1l", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A8I5ZRT2", "id": "A0A8I5ZRT2" }, { "name": "Dot1l", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102203", "id": "NP_001102203" } ], "protein_names": [ { "name": "Histone-lysine N-methyltransferase, H3 lysine-79 specific", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A8I5ZRT2#names_and_taxonomy", "id": "A0A8I5ZRT2" }, { "name": "DOT1-like, histone H3 methyltransferase; DOT1-like histone H3K79 methyltransferase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102203", "id": "NP_001102203" }, { "name": "histone-lysine N-methyltransferase, H3 lysine-79 specific", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102203", "id": "NP_001102203" } ], "function": [ { "annotation": "Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.", "evidence": [ { "database": "UniProtKB", "id": "D3ZCP0", "url": "https://www.uniprot.org/uniprot/D3ZCP0#function" }, { "database": "PubMed", "id": "RU271113", "url": "https://glygen.org/publication/PubMed/RU271113" }, { "database": "UniProtKB", "id": "A0A8I6AMR2", "url": "https://www.uniprot.org/uniprot/A0A8I6AMR2#function" }, { "database": "UniProtKB", "id": "A0A8I5ZRT2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZRT2#function" } ] }, { "annotation": "Histone methyltransferase. Methylates 'Lys-79' of histone H3.", "evidence": [ { "database": "UniProtKB", "id": "D3ZCP0", "url": "https://www.uniprot.org/uniprot/D3ZCP0#function" }, { "database": "PubMed", "id": "PIRNR037123", "url": "https://glygen.org/publication/PubMed/PIRNR037123" }, { "database": "UniProtKB", "id": "A0A8I6AMR2", "url": "https://www.uniprot.org/uniprot/A0A8I6AMR2#function" }, { "database": "UniProtKB", "id": "A0A8I5ZRT2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZRT2#function" } ] }, { "annotation": "Nullifying epigenetic writer DOT1L attenuates neointimal hyperplasia.", "evidence": [ { "database": "RefSeq", "id": "NP_001102203", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102203" }, { "database": "PubMed", "id": "32799103", "url": "https://glygen.org/publication/PubMed/32799103" } ] } ], "disease": [ { "disease_id": "DOID:0110425", "recommended_name": { "id": "DOID:0110425", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110425", "name": "dilated cardiomyopathy 1A", "description": "A dilated cardiomyopathy that has_material_basis_in mutation in the LMNA gene on chromosome 1q21." }, "synonyms": [ { "id": "DOID:0110425", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110425", "name": "familial dilated cardiomyopathy with conduction defect due to LMNA mutation", "description": "" }, { "id": "DOID:0110425", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110425", "name": "CDCD1", "description": "" }, { "id": "DOID:0110425", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110425", "name": "dilated cardiomyopathy with conduction defect 1", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "dilated cardiomyopathy 1A", "description": "Familial dilated cardiomyopathy with conduction defect due to LMNA mutation is a rare familial dilated cardiomyopathy characterized by left ventricular enlargement and/or reduced systolic function preceded or accompanied by significant conduction system disease and/or arrhythmias including bradyarrhythmias, supraventricular or ventricular arrhythmias. Disease onset is usually in early to mid-adulthood. Sudden cardiac death may occur and may be the presenting symptom. In some cases, it is associated with skeletal myopathy and elevated serum creatine kinase." }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "CDCD1", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "cardiomyopathy, familial idiopathic", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "cardiomyopathy, dilated, with conduction defect 1", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "CMD1A", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "LMNA familial isolated dilated cardiomyopathy", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "cardiomyopathy, idiopathic dilated", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "cardiomyopathy, dilated, 1A; CMD1A", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "cardiomyopathy, congestive", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "cardiomyopathy, dilated, type 1A", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "familial isolated dilated cardiomyopathy caused by mutation in LMNA", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "familial dilated cardiomyopathy with conduction defect due to LMNA mutation", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "dilated cardiomyopathy type 1A", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "cardiomyopathy, dilated, 1A", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "dilated cardiomyopathy with conduction defect 1", "description": "" }, { "id": "MIM:115200", "resource": "MIM", "url": "https://www.omim.org/entry/115200", "name": "Cardiomyopathy, dilated 1A", "description": "Cardiomyopathy, dilated 1A" } ], "evidence": [ { "id": "0110425", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0110425" } ] }, { "disease_id": "DOID:9953", "recommended_name": { "id": "DOID:9953", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9953", "name": "mixed phenotype acute leukemia", "description": "An acute leukemia that is characterized by the occurrence of more than one type of leukemia at the same time resulting from either the occurrence of blasts which coexpress myeloid and T or B lineage antigens or concurrent B and T lineage antigens." }, "synonyms": [], "evidence": [ { "id": "9953", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9953" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZRT2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZRT2" } ], "common_name": "Rat" } ], "gene": [ { "name": "Dot1l", "url": "https://www.uniprot.org/uniprot/A0A8I5ZRT2", "locus": { "chromosome": "7", "start_pos": 11824742, "end_pos": 11786105, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000032546", "url": "https://www.ensembl.org/id/ENSRNOG00000032546" } ] } } ], "crossref": [ { "id": "ENSRNOG00000032546", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000032546", "database": "Bgee" }, { "id": "362831", "url": "https://www.ncbi.nlm.nih.gov/gene/362831", "database": "GeneID" }, { "id": "IPR021169", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021169", "database": "InterPro" }, { "id": "IPR025789", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025789", "database": "InterPro" }, { "id": "IPR029063", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063", "database": "InterPro" }, { "id": "IPR030445", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030445", "database": "InterPro" }, { "id": "rno:362831", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:362831", "database": "KEGG Pathway" }, { "id": "SEKQRRC", "url": "https://omabrowser.org/oma/group/SEKQRRC/", "database": "OMA" }, { "id": "88676at2759", "url": "http://www.orthodb.org/?query=88676at2759", "database": "OrthoDB" }, { "id": "PTHR21451", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21451", "database": "PANTHER" }, { "id": "PF08123", "url": "http://pfam.xfam.org/family/PF08123", "database": "Pfam" }, { "id": "R-RNO-3214841", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3214841", "database": "Reactome" }, { "id": "NP_001102203", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102203", "database": "RefSeq" }, { "id": "1306644", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1306644", "database": "RGD" }, { "id": "60328", "url": "https://www.rhea-db.org/rhea/60328", "database": "Rhea" }, { "id": "A0A8I5ZRT2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZRT2", "database": "UniProtKB" }, { "id": "A0A8I5ZRT2-1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZRT2-1", "database": "UniProtKB" }, { "id": "A0A8I6AMR2", "url": "https://www.uniprot.org/uniprot/A0A8I6AMR2", "database": "UniProtKB" }, { "id": "A0A8I6AMR2-1", "url": "https://www.uniprot.org/uniprot/A0A8I6AMR2-1", "database": "UniProtKB" }, { "id": "D3ZCP0", "url": "https://www.uniprot.org/uniprot/D3ZCP0", "database": "UniProtKB" }, { "id": "D3ZCP0-1", "url": "https://www.uniprot.org/uniprot/D3ZCP0-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVLIDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSNGLLRHILQQVYNHSVTDPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCKHHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRENKSNATTPTKVPESKAAATEAPADSGAEEEKSGVATVKKQSPSKARKKKLNKKGRKMAGRKRGRPKKMSAASADRKSKKSQSTLDLLHSPPPAPPSASPQDAYRAPHSPFYQLPPSTPLHSPDPLLVAPTPPALQKLLESFKIQYLQFLAYTKTPQYKANLQQLLDQEKEKNTQLLGTAQQLFSHCQAQKEEIRRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQSEQLEKDNSELRSQSLRLLRARCEELRLDWSTLSLENLRKEKQALRSQISEKQRHCLELQISIVELEKTQRQQELLQLKSCVPPDDALSLHLRGKGALGRELESDAGRLRLELDCAKLSLPHLSSMSPELSMNGHAASYELCGAASRPSSKQNTPQYLASPLDQEVVPCTPSHSGRPRLEKLSGLALPDYTRLSPAKIVLRRHLSQDHTGASKAATSEPHPRPEHAKENSLPYQSPGLSNSMKLSPQDPPLASPATSPLTSERGSEKGVKERAYSSHGETITSLPVSIPLSTVQPNKLPVSIPLASVVLPSRAERARSTPSPVPQPRDSSSTLEKQIGASTHGAGGAAAGSRSLTVAPTGFYAGSVAISGALASSPAPLASGMESAVFEESSGPSSLFGTMGSRSTPPQHPPLLPQSRNSGPASPAHQLAASPRLSVTTQGSLPDTGKGELPADPAFSDPESEAKRRIVFSISAGASSRQSPSTRHSPLTSGTRGDCVQSHGQDSRKRSRRKRASAGTPSLTTGVSPKRRALPTVAGLFTQSSGSPLNLTSMVSNINQPLEITAISSPESSLKSSPTPYQDHDQPPVLRKERPLGPTNGAHYSPLTSDEEPGSEDEPSSARIERKIATISLESKSPPKTLENGGGLVGRKPVPSGEPVNSSKWKSTFSPISDLGLAKAMDSPLQASSALSHSPLFSFRPSLEEPAAEAKPSTHPRKSFAGSLAAAEGPSPGTNPPNSLAFSGGLAADLGLHSFNDGASLSHKGPEVAGLSASLSFPSQRGKDSTTEANPFLSRRQPEGLGGLKGEGNASKESGESLPLCGPSDKVSLPHGSRASKGRDRELDFKGGHNLFISAAAVPPGGLLGGPGLVTVASSAGSATPSAQAPRPFLSTFAPGPQFTLGPMSLQANLGSVAGSSVLQSLFSTVPAAAGLVHVSSTATRLTNSHTMGSFSSGVAGGTVGGVFTHAVPSASAHPFGAGVGSGAVCSSATLGLSPLQAAASTSASSFQAAASVETRPPPPPPLLPPQHLGRPPAGPPVLHAPPPPNVALPPPPALLASNPEPVLLQSLASLPANNAFLPPSSASSLQPANASLSVKLASLPHKVSRPSFTVHHQPLPRLALAQAAPAAPQASTSGPSAVWVSLGMPPPYAAHLSGVKPR", "length": 1736, "header": "tr|A0A8I5ZRT2-1|A0A8I5ZRT2_RAT Isoform 1 of Histone-lysine N-methyltransferase, H3 lysine-79 specific OS=Rattus norvegicus OX=10116 GN=Dot1l PE=3 SV=1 CANONICAL=A0A8I5ZRT2-1" }, "isoforms": [ { "isoform_ac": "A0A8I5ZRT2-1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZRT2#A0A8I5ZRT2-1", "sequence": { "sequence": "MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVLIDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSNGLLRHILQQVYNHSVTDPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCKHHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRENKSNATTPTKVPESKAAATEAPADSGAEEEKSGVATVKKQSPSKARKKKLNKKGRKMAGRKRGRPKKMSAASADRKSKKSQSTLDLLHSPPPAPPSASPQDAYRAPHSPFYQLPPSTPLHSPDPLLVAPTPPALQKLLESFKIQYLQFLAYTKTPQYKANLQQLLDQEKEKNTQLLGTAQQLFSHCQAQKEEIRRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQSEQLEKDNSELRSQSLRLLRARCEELRLDWSTLSLENLRKEKQALRSQISEKQRHCLELQISIVELEKTQRQQELLQLKSCVPPDDALSLHLRGKGALGRELESDAGRLRLELDCAKLSLPHLSSMSPELSMNGHAASYELCGAASRPSSKQNTPQYLASPLDQEVVPCTPSHSGRPRLEKLSGLALPDYTRLSPAKIVLRRHLSQDHTGASKAATSEPHPRPEHAKENSLPYQSPGLSNSMKLSPQDPPLASPATSPLTSERGSEKGVKERAYSSHGETITSLPVSIPLSTVQPNKLPVSIPLASVVLPSRAERARSTPSPVPQPRDSSSTLEKQIGASTHGAGGAAAGSRSLTVAPTGFYAGSVAISGALASSPAPLASGMESAVFEESSGPSSLFGTMGSRSTPPQHPPLLPQSRNSGPASPAHQLAASPRLSVTTQGSLPDTGKGELPADPAFSDPESEAKRRIVFSISAGASSRQSPSTRHSPLTSGTRGDCVQSHGQDSRKRSRRKRASAGTPSLTTGVSPKRRALPTVAGLFTQSSGSPLNLTSMVSNINQPLEITAISSPESSLKSSPTPYQDHDQPPVLRKERPLGPTNGAHYSPLTSDEEPGSEDEPSSARIERKIATISLESKSPPKTLENGGGLVGRKPVPSGEPVNSSKWKSTFSPISDLGLAKAMDSPLQASSALSHSPLFSFRPSLEEPAAEAKPSTHPRKSFAGSLAAAEGPSPGTNPPNSLAFSGGLAADLGLHSFNDGASLSHKGPEVAGLSASLSFPSQRGKDSTTEANPFLSRRQPEGLGGLKGEGNASKESGESLPLCGPSDKVSLPHGSRASKGRDRELDFKGGHNLFISAAAVPPGGLLGGPGLVTVASSAGSATPSAQAPRPFLSTFAPGPQFTLGPMSLQANLGSVAGSSVLQSLFSTVPAAAGLVHVSSTATRLTNSHTMGSFSSGVAGGTVGGVFTHAVPSASAHPFGAGVGSGAVCSSATLGLSPLQAAASTSASSFQAAASVETRPPPPPPLLPPQHLGRPPAGPPVLHAPPPPNVALPPPPALLASNPEPVLLQSLASLPANNAFLPPSSASSLQPANASLSVKLASLPHKVSRPSFTVHHQPLPRLALAQAAPAAPQASTSGPSAVWVSLGMPPPYAAHLSGVKPR", "length": 1736, "header": "tr|A0A8I5ZRT2-1|A0A8I5ZRT2_RAT Isoform 1 of Histone-lysine N-methyltransferase, H3 lysine-79 specific OS=Rattus norvegicus OX=10116 GN=Dot1l PE=3 SV=1 CANONICAL=A0A8I5ZRT2-1" }, "locus": { "chromosome": "7", "start_pos": 8956184, "end_pos": 8921466, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000118608.1", "url": "https://www.ensembl.org/id/ENSRNOT00000118608.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000081362.1", "url": "https://www.ensembl.org/id/ENSRNOP00000081362.1" } ] } }, { "isoform_ac": "A0A8I6AMR2-1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZRT2#A0A8I6AMR2-1", "sequence": { "sequence": "MGEKLELRLKSPVGAEPAVYPWPLPVYVSVLAENPGVGVVGLRALHVCASWVYCSPITPLTLSLPPSPLSFFSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSNGLLRHILQQVYNHSVTDPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCKHHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTIILQRCGHLPTTSLQEEQEAARRRQQRENKSNATTPTKVPESKAAATEAPADSGAEEEKSGVATVKKQSPSKARKKKLNKKGRKMAGRKRGRPKKMSAASADRKSKKSQSTLDLLHSPPPAPPSASPQDAYRAPHSPFYQLPPSTPLHSPDPLLVAPTPPALQKLLESFKIQYLQFLAYTKTPQYKANLQQLLDQEKEKNTQLLGTAQQLFSHCQAQKEEIRRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQSEQLEKDNSELRSQSLRLLRARCEELRLDWSTLSLENLRKEKQALRSQISEKQRHCLELQISIVELEKTQRQQELLQLKSCVPPDDALSLHLRGKGALGRELESDAGRLRLELDCAKLSLPHLSSMSPELSMNGHAASYELCGAASRPSSKQNTPQYLASPLDQEVVPCTPSHSGRPRLEKLSGLALPDYTRLSPAKIVLRRHLSQDHTGASKAATSEPHPRPEHAKENSLPYQSPGLSNSMKLSPQDPPLASPATSPLTSERGSEKGVKERAYSSHGETITSLPVSIPLSTVQPNKLPVSIPLASVVLPSRAERARSTPSPVPQPRDSSSTLEKQIGASTHGAGGAAAGSRSLTVAPTGFYAGSVAISGALASSPAPLASGMESAVFEESSGPSSLFGTMGSRSTPPQHPPLLPQSRNSGPASPAHQLAASPRLSVTTQGSLPDTGKGELPADPAFSDPESEAKRRIVFSISAGASSRQSPSTRHSPLTSGTRGDCVQSHGQDSRKRSRRKRASAGTPSLTTGVSPKRRALPTVAGLFTQSSGSPLNLTSMVSNINQPLEITAISSPESSLKSSPTPYQDHDQPPVLRKERPLGPTNGAHYSPLTSDEEPGSEDEPSSARIERKIATISLESKSPPKTLENGGGLVGRKPVPSGEPVNSSKWKSTFSPISDLGLAKAMDSPLQASSALSHSPLFSFRPSLEEPAAEAKPSTHPRKSFAGSLAAAEGPSPGTNPPNSLAFSGGLAADLGLHSFNDGASLSHKGPEVAGLSASLSFPSQRGKDSTTEANPFLSRRQPEGLGGLKGEGNASKESGESLPLCGPSDKVSLPHGSRASKGRDRELDFKGGHNLFISAAAVPPGGLLGGPGLVTVASSAGSATPSAQAPRPFLSTFAPGPQFTLGPMSLQANLGSVAGSSVLQSLFSTVPAAAGLVHVSSTATRLTNSHTMGSFSSGVAGGTVGGRQGRANF", "length": 1552, "header": "tr|A0A8I6AMR2-1|A0A8I5ZRT2_RAT Computationally mapped isoform of Histone-lysine N-methyltransferase, H3 lysine-79 specific OS=Rattus norvegicus OX=10116 GN=Dot1l PE=3 SV=1 CANONICAL=A0A8I5ZRT2-1" }, "locus": { "chromosome": "7", "start_pos": 8956184, "end_pos": 8922640, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000116154.1", "url": "https://www.ensembl.org/id/ENSRNOT00000116154.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000095270.1", "url": "https://www.ensembl.org/id/ENSRNOP00000095270.1" } ] } }, { "isoform_ac": "D3ZCP0-1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZRT2#D3ZCP0-1", "sequence": { "sequence": "MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVLIDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSNGLLRHILQQVYNHSVTDPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCKHHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRENKSNATTPTKVPESKAAATEAPADSGAEEEKSGVATVKKQSPSKARKKKLNKKGRKMAGRKRGRPKKMSAASADRKSKKSQSTLDLLHSPPPAPPSASPQDAYRAPHSPFYQLPPSTPLHSPDPLLVAPTPPALQKLLESFKIQYLQFLAYTKTPQYKANLQQLLDQEKEKNTQLLGTAQQLFSHCQAQKEEIRRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQSEQLEKDNSELRSQSLRLLRARCEELRLDWSTLSLENLRKEKQALRSQISEKQRHCLELQISIVELEKTQRQQELLQLKSCVPPDDALSLHLRGKGALGRELESDAGRLRLELDCAKLSLPHLSSMSPELSMNGHAASYELCGAASRPSSKQNTPQYLASPLDQEVVPCTPSHSGRPRLEKLSGLALPDYTRLSPAKIVLRRHLSQDHTGASKAATSEPHPRPEHAKENSLPYQSPGLSNSMKLSPQDPPLASPATSPLTSERGSEKGVKERAYSSHGETITSLPVSIPLSTVQPNKLPVSIPLASVVLPSRAERARSTPSPVPQPRDSSSTLEKQIGASTHGAGGAAAGSRSLTVAPTGFYAGSVAISGALASSPAPLASGMESAVFEESSGPSSLFGTMGSRSTPPQHPPLLPQSRNSGPASPAHQLAASPRLSVTTQGSLPDTGKGELPADPAFSDPESEAKRRIVFSISAGASSRQSPSTRHSPLTSGTRGDCVQSHGQDSRKRSRRKRASAGTPSLTTGVSPKRRALPTVAGLFTQSSGSPLNLTSMVSNINQPLEITAISSPESSLKSSPTPYQDHDQPPVLRKERPLGPTNGAHYSPLTSDEEPGSEDEPSSARIERKIATISLESKSPPKTLENGGGLVGRKPVPSGEPVNSSKWKSTFSPISDLGLAKAMDSPLQASSALSHSPLFSFRPSLEEPAAEAKPSTHPRKSFAGSLAAAEGPSPGTNPPNSLAFSGGLAADLGLHSFNDGASLSHKGPEVAGLSASLSFPSQRGKDSTTEANPFLSRRQPEGLGGLKGEGNASKESGESLPLCGPSDKVSLPHGSRASKGRDRELDFKGGHNLFISAAAVPPGGLLGGPGLVTVASSAGSATPSAQAPRPFLSTFAPGPQFTLGPMSLQANLGSVAGSSVLQSLFSTVPAAAGLVHVSSTATRLTNSHTMGSFSSGVAGGTVGGN", "length": 1540, "header": "tr|D3ZCP0-1|A0A8I5ZRT2_RAT Computationally mapped isoform of Histone-lysine N-methyltransferase, H3 lysine-79 specific OS=Rattus norvegicus OX=10116 GN=Dot1l PE=3 SV=2 CANONICAL=A0A8I5ZRT2-1" }, "locus": { "chromosome": "7", "start_pos": 8956184, "end_pos": 8920665, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000051467.5", "url": "https://www.ensembl.org/id/ENSRNOT00000051467.5" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000043691.4", "url": "https://www.ensembl.org/id/ENSRNOP00000043691.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Structure of the catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase.", "journal": "Cell", "date": "2003", "authors": "Min J, Feng Q, Li Z, Zhang Y, Xu RM", "evidence": [ { "database": "RefSeq", "id": "NP_001102203", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102203" } ], "reference": [ { "type": "PubMed", "id": "12628190", "url": "https://glygen.org/publication/PubMed/12628190" } ] }, { "title": "Structure and regulation of the mDot1 gene, a mouse histone H3 methyltransferase.", "journal": "The Biochemical journal", "date": "2004", "authors": "Zhang W, Hayashizaki Y, Kone BC", "evidence": [ { "database": "RefSeq", "id": "NP_001102203", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102203" } ], "reference": [ { "type": "PubMed", "id": "14572310", "url": "https://glygen.org/publication/PubMed/14572310" } ] }, { "title": "hDOT1L links histone methylation to leukemogenesis.", "journal": "Cell", "date": "2005", "authors": "Okada Y, Feng Q, Lin Y, Jiang Q, Li Y, Coffield VM, Su L, Xu G, Zhang Y", "evidence": [ { "database": "RefSeq", "id": "NP_001102203", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102203" } ], "reference": [ { "type": "PubMed", "id": "15851025", "url": "https://glygen.org/publication/PubMed/15851025" } ] }, { "title": "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2006", "authors": "Wang G., Shen R.F., Knepper M.A., Shen R.-F., Hoffert J.D., Pisitkun T.", "evidence": [ { "database": "UniProtKB", "id": "D3ZCP0", "url": "https://www.uniprot.org/uniprot/D3ZCP0" } ], "reference": [ { "type": "PubMed", "id": "16641100", "url": "https://glygen.org/publication/PubMed/16641100" } ] }, { "title": "Modulation of p53 function by SET8-mediated methylation at lysine 382.", "journal": "Molecular cell", "date": "2007", "authors": "Shi X, Kachirskaia I, Yamaguchi H, West LE, Wen H, Wang EW, Dutta S, Appella E, Gozani O", "evidence": [ { "database": "RefSeq", "id": "NP_001102203", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102203" } ], "reference": [ { "type": "PubMed", "id": "17707234", "url": "https://glygen.org/publication/PubMed/17707234" } ] }, { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nat. Commun.", "date": "2012", "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "evidence": [ { "database": "UniProtKB", "id": "D3ZCP0", "url": "https://www.uniprot.org/uniprot/D3ZCP0" } ], "reference": [ { "type": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" } ] }, { "title": "Histone lysine methylation dynamics: establishment, regulation, and biological impact.", "journal": "Molecular cell", "date": "2012", "authors": "Black JC, Van Rechem C, Whetstine JR", "evidence": [ { "database": "RefSeq", "id": "NP_001102203", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102203" } ], "reference": [ { "type": "PubMed", "id": "23200123", "url": "https://glygen.org/publication/PubMed/23200123" } ] }, { "title": "Potent inhibition of DOT1L as treatment of MLL-fusion leukemia.", "journal": "Blood", "date": "2013", "authors": "Daigle SR, Olhava EJ, Therkelsen CA, Basavapathruni A, Jin L, Boriack-Sjodin PA, Allain CJ, Klaus CR, Raimondi A, Scott MP, Waters NJ, Chesworth R, Moyer MP, Copeland RA, Richon VM, Pollock RM", "evidence": [ { "database": "RefSeq", "id": "NP_001102203", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102203" } ], "reference": [ { "type": "PubMed", "id": "23801631", "url": "https://glygen.org/publication/PubMed/23801631" } ] }, { "title": "Nullifying epigenetic writer DOT1L attenuates neointimal hyperplasia.", "journal": "Atherosclerosis", "date": "2020", "authors": "Huang Y, Urabe G, Zhang M, Li J, Ozer HG, Wang B, Kent KC, Guo LW", "evidence": [ { "database": "RefSeq", "id": "NP_001102203", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102203" } ], "reference": [ { "type": "PubMed", "id": "32799103", "url": "https://glygen.org/publication/PubMed/32799103" } ] } ], "pathway": [ { "id": "rno:362831", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:362831", "resource": "KEGG Pathway" }, { "id": "R-RNO-3214841", "name": "PKMTs methylate histone lysines", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-3214841", "resource": "Reactome", "description": "PKMTs methylate histone lysines" } ], "orthologs": [ { "uniprot_canonical_ac": "Q6XZL8-1", "protein_name": "Histone-lysine N-methyltransferase, H3 lysine-79 specific", "gene_name": "Dot1l", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVLIDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSNGLLRHILQQVYNHSVTDPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCKHHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRENKSNATTPTKVPESKAAATEAPADSGAEEEKSGVATVKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMSAASAERKSKKSQSTLDLLHSPPPAPPSASPQDAYRAPHSPFYQLPPSTQLHSPNPLLVAPTPPALQKLLESFRIQYLQFLAYTKTPQYKANLQQLLDQEKEKNTQLLGTAQQLFGHCQAQKEEIRRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQSEQLEKDNSELRSQSLRLLRARCEELRLDWSTLSLENLRKEKQALRSQISEKQRHCLELQISIVELEKTQRQQELLQLKSCVPPDDALSLHLRGKGALGRELEADAGRLRLELDCAKISLPHLSSMSPELSMNGHAASYELCNAASRPSSKQNTPQYLASPLDQEVVPCTPSHSGRPRLEKLSGLALPDYTRLSPAKIVLRRHLSQDHTGASKAATSEPHPRPEHPKESSLPYQSPGLSNSMKLSPQDPPLASPATSPLTSEKGSEKGVKERAYSSHGETITSLPVSIPLSTVQPNKLPVSIPLASVVLPSRAERARSTPSPVPQPRDSSATLEKQTGASAHGAGGAGAGSRSLAVAPTGFYAGSVAISGALASSPAPLASGMESAVFDESSGPSSLFATMGSRSTPPQHPPLLSQSRNSGPASPAHQLTASPRLSVTTQGSLPDTSKGELPSDPAFSDPESEAKRRIVFSISVGASSKQSPSTRHSPLTSGTRGDCVQSHGQDSRKRSRRKRASAGTPSLSTGVSPKRRALPTVAGLFTQSSGSPLNLNSMVSNINQPLEITAISSPESSLKSSPTPYQDHDQPPVLRKERPLGLTNGAHYSPLTSDEEPGSEDEPSSARIERKIATISLESKSPPKTLENGGGLVGRKSAPSSEPINSSKWKSTFSPISDLGLAKAVDSPLQAGSALSHSPLFSFRPSLEEPAAEAKLPTHPRKSFAGSLGAAEGPSPGTNPPNGLAFSGGLAADLGLHSFNDGASLSHKGPDVTGLSASLSFPSQRGKDSTTEANPFLSRRQPEGLGGLKGEGNANKESGESLPLCGPSDKASLPHGSRASKGRDRELDFKGGHNLFISAAAVPPGGLLGGPGLVTVASSAGSATPTAQAPRPFLSTFAPGPQFTLGPMSLQANLGSVAGSSVLQSLFSTVPAAAGLVHVSSTATRLTNSHTMGSFSSGVAGGTVGGN", "length": 1540 }, "evidence": [ { "id": "41496232", "url": "http://www.informatics.jax.org/homology/41496232", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8TEK3-2", "protein_name": "Histone-lysine N-methyltransferase, H3 lysine-79 specific", "gene_name": "DOT1L", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVLIDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSTGLLRHILQQVYNHSVTDPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTDDDLFVDLGSGVGQVVLQVAAATNCKHHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRESKSNAATPTKGPEGKVAGPADAPMDSGAEEEKAGAATVKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMNTANPERKPKKNQTALDALHAQTVSQTAASSPQDAYRSPHSPFYQLPPSVQRHSPNPLLVAPTPPALQKLLESFKIQYLQFLAYTKTPQYKASLQELLGQEKEKNAQLLGAAQQLLSHCQAQKEEIRRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQSEQLEQDNRALRGQSLQLLKARCEELQLDWATLSLEKLLKEKQALKSQISEKQRHCLELQISIVELEKSQRQQELLQLKSCVPPDDALSLHLRGKGALGRELEPDASRLHLELDCTKFSLPHLSSMSPELSMNGQAAGYELCGVLSRPSSKQNTPQYLASPLDQEVVPCTPSHVGRPRLEKLSGLAAPDYTRLSPAKIVLRRHLSQDHTVPGRPAASELHSRAEHTKENGLPYQSPSVPGSMKLSPQDPRPLSPGALQLAGEKSSEKGLRERAYGSSGELITSLPISIPLSTVQPNKLPVSIPLASVVLPSRAERARSTPSPVLQPRDPSSTLEKQIGANAHGAGSRSLALAPAGFSYAGSVAISGALAGSPASLTPGAEPATLDESSSSGSLFATVGSRSSTPQHPLLLAQPRNSLPASPAHQLSSSPRLGGAAQGPLPEASKGDLPSDSGFSDPESEAKRRIVFTITTGAGSAKQSPSSKHSPLTASARGDCVPSHGQDSRRRGRRKRASAGTPSLSAGVSPKRRALPSVAGLFTQPSGSPLNLNSMVSNINQPLEITAISSPETSLKSSPVPYQDHDQPPVLKKERPLSQTNGAHYSPLTSDEEPGSEDEPSSARIERKIATISLESKSPPKTLENGGGLAGRKPAPAGEPVNSSKWKSTFSPISDIGLAKSADSPLQASSALSQNSLFTFRPALEEPSADAKLAAHPRKGFPGSLSGADGLSPGTNPANGCTFGGGLAADLSLHSFSDGASLPHKGPEAAGLSSPLSFPSQRGKEGSDANPFLSKRQLDGLAGLKGEGSRGKEAGEGGLPLCGPTDKTPLLSGKAAKARDREVDLKNGHNLFISAAAVPPGSLLSGPGLAPAASSAGGAASSAQTHRSFLGPFPPGPQFALGPMSLQANLGSVAGSSVLQSLFSSVPAAAGLVHVSSAATRLTNSHAMGSFSGVAGGTVGGN", "length": 1537 }, "evidence": [ { "id": "41496232", "url": "http://www.informatics.jax.org/homology/41496232", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "histone H3-K79 methylation", "id": "GO:0034729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034729", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZRT2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZRT2" } ], "pmid": "" }, { "name": "regulation of receptor signaling pathway via JAK-STAT", "id": "GO:0046425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046425", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZRT2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZRT2" } ], "pmid": "" }, { "name": "regulation of transcription regulatory region DNA binding", "id": "GO:2000677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000677", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZRT2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZRT2" } ], "pmid": "" }, { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZRT2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZRT2" } ], "pmid": "21873635" }, { "name": "positive regulation of cell population proliferation", "id": "GO:0008284", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008284", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZRT2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZRT2" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZRT2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZRT2" } ], "pmid": "" }, { "name": "DNA damage checkpoint signaling", "id": "GO:0000077", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000077", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZRT2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZRT2" } ], "pmid": "21873635" }, { "name": "gene expression", "id": "GO:0010467", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010467", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZRT2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZRT2" } ], "pmid": "" }, { "name": "heterochromatin assembly", "id": "GO:0031507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031507", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZRT2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZRT2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZRT2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZRT2" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZRT2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZRT2" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZRT2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZRT2" } ], "pmid": "" }, { "name": "chromosome, telomeric region", "id": "GO:0000781", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000781", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZRT2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZRT2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "histone methyltransferase activity", "id": "GO:0042054", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042054", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZRT2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZRT2" } ], "pmid": "" }, { "name": "histone-lysine N-methyltransferase activity", "id": "GO:0018024", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018024", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZRT2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZRT2" } ], "pmid": "" }, { "name": "histone methyltransferase activity (H3-K79 specific)", "id": "GO:0031151", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031151", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZRT2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZRT2" } ], "pmid": "21873635" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1127, "end_pos": 1129, "annotation": "n_glycosylation_sequon" }, { "start_pos": 116, "end_pos": 118, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1238, "end_pos": 1240, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1386, "end_pos": 1388, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1667, "end_pos": 1669, "annotation": "n_glycosylation_sequon" }, { "start_pos": 234, "end_pos": 236, "annotation": "n_glycosylation_sequon" }, { "start_pos": 283, "end_pos": 285, "annotation": "n_glycosylation_sequon" }, { "start_pos": 349, "end_pos": 351, "annotation": "n_glycosylation_sequon" }, { "start_pos": 352, "end_pos": 354, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "60328", "name": "", "equation": "L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8TEK3-2", "Q6XZL8-1", "Q8INR6-1" ], "evidence": [ { "id": "60328", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/60328" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "Q6XZL8", "gene_name": "Dot1l", "activity": [ { "ec_number": "2.1.1.360", "activity": "L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + 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