{ "uniprot_canonical_ac": "A0A8I5ZLS0-1", "uniprot_ac": "A0A8I5ZLS0", "uniprot_id": "A0A8I5ZLS0_RAT", "mass": { "chemical_mass": 57507.0, "monoisotopic_mass": 57507.0 }, "refseq": { "ac": "NP_001291284", "name": "vascular endothelial zinc finger 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291284" }, "gene_names": [ { "name": "Vezf1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/A0A8I5ZLS0", "id": "A0A8I5ZLS0" }, { "name": "Vezf1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291284", "id": "NP_001291284" } ], "protein_names": [ { "name": "Vascular endothelial zinc finger 1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/A0A8I5ZLS0#names_and_taxonomy", "id": "A0A8I5ZLS0" }, { "name": "vascular endothelial zinc finger 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291284", "id": "NP_001291284" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZLS0", "url": "https://www.uniprot.org/uniprot/A0A8I5ZLS0" } ], "common_name": "Rat" } ], "gene": [ { "name": "Vezf1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZLS0", "locus": { "chromosome": "10", "start_pos": 75365822, "end_pos": 75381555, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000009819", "url": "https://www.ensembl.org/id/ENSRNOG00000009819" } ] } } ], "crossref": [ { "id": "ENSRNOG00000009819", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000009819", "database": "Bgee" }, { "id": "287615", "url": "https://www.ncbi.nlm.nih.gov/gene/287615", "database": "GeneID" }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro" }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro" }, { "id": "rno:287615", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:287615", "database": "KEGG Pathway" }, { "id": "A0A8I5ZLS0", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A0A8I5ZLS0", "database": "O-GlcNAc Database" }, { "id": "AMNRGNN", "url": "https://omabrowser.org/oma/group/AMNRGNN/", "database": "OMA" }, { "id": "1318335at2759", "url": "http://www.orthodb.org/?query=1318335at2759", "database": "OrthoDB" }, { "id": "PF00096", "url": "http://pfam.xfam.org/family/PF00096", "database": "Pfam" }, { "id": "NP_001291284", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291284", "database": "RefSeq" }, { "id": "1308058", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1308058", "database": "RGD" }, { "id": "A0A8I5ZLS0", "url": "https://www.uniprot.org/uniprot/A0A8I5ZLS0", "database": "UniProtKB" }, { "id": "A0A8I5ZLS0-1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZLS0-1", "database": "UniProtKB" }, { "id": "F1M8R0", "url": "https://www.uniprot.org/uniprot/F1M8R0", "database": "UniProtKB" }, { "id": "F1M8R0-1", "url": "https://www.uniprot.org/uniprot/F1M8R0-1", "database": "UniProtKB" } ], "sequence": { "sequence": "MEANWTAFLFQAHEASHHQQQAAQNSLLPLLSSAVEPPDQKPLLPIPITQKPQAAPETLKDAIGIKKEKPKTSFVCTYCSKAFRDSYHLRRHQSCHTGIKLVSRAKKTPTTVVPLISTIAGDSSRTSLVSTIAGILSTVTTSSSGTNPSSSASTTAMPVPQSVKKPSKPVKKNHACEMCGKAFRDVYHLNRHKLSHSDEKPFECPICNQRFKRKDRMTYHVRSHEGGITKPYTCSVCGKGFSRPDHLSCHVKHVHSTERPFKCQFSSLMQTCTAAFATKDRLRTHMVRHEGKVSCNICGKLLSAAYITSHLKTHGQSQSINCNTCKQGISKTCMSEETSNQKQQQQQQQQQQQQQQQQQHVTSWPGKQVETLRLWEEAVKARKKEAANLCQTSTAATTPVTLTTPFNITSSVSSGTMSNPVTVAAAMSMRSPVNVSSAVNITSPMNIGHPVTITSPLSMTSPLTLTTPVNLPTPVTAPVNIAHPVTITSPMNLPTPMTLAAPLNIAMRPVESMPFLPQALPTSPPW", "length": 526, "header": "tr|A0A8I5ZLS0-1|A0A8I5ZLS0_RAT Isoform 1 of Vascular endothelial zinc finger 1 OS=Rattus norvegicus OX=10116 GN=Vezf1 PE=4 SV=1 CANONICAL=A0A8I5ZLS0-1" }, "isoforms": [ { "isoform_ac": "A0A8I5ZLS0-1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZLS0#A0A8I5ZLS0-1", "sequence": { "sequence": "MEANWTAFLFQAHEASHHQQQAAQNSLLPLLSSAVEPPDQKPLLPIPITQKPQAAPETLKDAIGIKKEKPKTSFVCTYCSKAFRDSYHLRRHQSCHTGIKLVSRAKKTPTTVVPLISTIAGDSSRTSLVSTIAGILSTVTTSSSGTNPSSSASTTAMPVPQSVKKPSKPVKKNHACEMCGKAFRDVYHLNRHKLSHSDEKPFECPICNQRFKRKDRMTYHVRSHEGGITKPYTCSVCGKGFSRPDHLSCHVKHVHSTERPFKCQFSSLMQTCTAAFATKDRLRTHMVRHEGKVSCNICGKLLSAAYITSHLKTHGQSQSINCNTCKQGISKTCMSEETSNQKQQQQQQQQQQQQQQQQQHVTSWPGKQVETLRLWEEAVKARKKEAANLCQTSTAATTPVTLTTPFNITSSVSSGTMSNPVTVAAAMSMRSPVNVSSAVNITSPMNIGHPVTITSPLSMTSPLTLTTPVNLPTPVTAPVNIAHPVTITSPMNLPTPMTLAAPLNIAMRPVESMPFLPQALPTSPPW", "length": 526, "header": "tr|A0A8I5ZLS0-1|A0A8I5ZLS0_RAT Isoform 1 of Vascular endothelial zinc finger 1 OS=Rattus norvegicus OX=10116 GN=Vezf1 PE=4 SV=1 CANONICAL=A0A8I5ZLS0-1" }, "locus": { "chromosome": "10", "start_pos": 72873306, "end_pos": 72859998, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000096619.1", "url": "https://www.ensembl.org/id/ENSRNOT00000096619.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000078894.1", "url": "https://www.ensembl.org/id/ENSRNOP00000078894.1" } ] } }, { "isoform_ac": "F1M8R0-1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZLS0#F1M8R0-1", "sequence": { "sequence": "LRNNWQAHEASHHQQQAAQNSLLPLLSSAVEPPDQKPLLPIPITQKPQAAPETLKDAIGIKKEKPKTSFVCTYCSKAFRDSYHLRRHQSCHTGIKLVSRAKKTPTTVVPLISTIAGDSSRTSLVSTIAGILSTVTTSSSGTNPSSSASTTAMPVPQSVKKPSKPVKKNHACEMCGKAFRDVYHLNRHKLSHSDEKPFECPICNQRFKRKDRMTYHVRSHEGGITKPYTCSVCGKGFSRPDHLSCHVKHVHSTERPFKCQTCTAAFATKDRLRTHMVRHEGKVSCNICGKLLSAAYITSHLKTHGQSQSINCNTCKQGISKTCMSEETSNQKQQQQQQQQQQQQQQQQQHVTSWPGKQVETLRLWEEAVKARKKEAANLCQTSTAATTPVTLTTPFNITSSVSSGTMSNPVTVAAAMSMRSPVNVSSAVNITSPMNIGHPVTITSPLSMTSPLTLTTPVNLPTPVTAPVNIAHPVTITSPMNLPTPMTLAAPLNIAMRPVESMPFLPQALPTSPPW", "length": 515, "header": "tr|F1M8R0-1|F1M8R0_RAT Computationally mapped isoform of Vascular endothelial zinc finger 1 OS=Rattus norvegicus OX=10116 GN=Vezf1 PE=1 SV=4 CANONICAL=A0A8I5ZLS0-1" }, "locus": { "chromosome": "10", "start_pos": 72873306, "end_pos": 72863662, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000055705.5", "url": "https://www.ensembl.org/id/ENSRNOT00000055705.5" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000052564.5", "url": "https://www.ensembl.org/id/ENSRNOP00000052564.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "A0A8I5ZLS0", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A0A8I5ZLS0" }, { "id": "18683930", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/18683930" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Direct in-gel fluorescence detection and cellular imaging of O-GlcNAc-modified proteins.", "journal": "Journal of the American Chemical Society", "date": "2008", "authors": "Clark PM, Dweck JF, Mason DE, Hart CR, Buck SB, Peters EC, Agnew BJ, Hsieh-Wilson LC", "evidence": [ { "database": "O-GlcNAc Database", "id": "A0A8I5ZLS0", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=A0A8I5ZLS0" } ], "reference": [ { "type": "PubMed", "id": "18683930", "url": "https://glygen.org/publication/PubMed/18683930" } ] }, { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nat. Commun.", "date": "2012", "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "evidence": [ { "database": "UniProtKB", "id": "F1M8R0", "url": "https://www.uniprot.org/uniprot/F1M8R0" } ], "reference": [ { "type": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" } ] }, { "title": "Inhibition of microRNA-495 Enhances Therapeutic Angiogenesis of Human Induced Pluripotent Stem Cells.", "journal": "Stem cells (Dayton, Ohio)", "date": "2017", "authors": "Liang J, Huang W, Cai W, Wang L, Guo L, Paul C, Yu XY, Wang Y", "evidence": [ { "database": "RefSeq", "id": "NP_001291284", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291284" } ], "reference": [ { "type": "PubMed", "id": "27538588", "url": "https://glygen.org/publication/PubMed/27538588" } ] } ], "pathway": [ { "id": "rno:287615", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:287615", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q14119-1", "protein_name": "Vascular endothelial zinc finger 1", "gene_name": "VEZF1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEANWTAFLFQAHEASHHQQQAAQNSLLPLLSSAVEPPDQKPLLPIPITQKPQGAPETLKDAIGIKKEKPKTSFVCTYCSKAFRDSYHLRRHESCHTGIKLVSRPKKTPTTVVPLISTIAGDSSRTSLVSTIAGILSTVTTSSSGTNPSSSASTTAMPVTQSVKKPSKPVKKNHACEMCGKAFRDVYHLNRHKLSHSDEKPFECPICNQRFKRKDRMTYHVRSHEGGITKPYTCSVCGKGFSRPDHLSCHVKHVHSTERPFKCQTCTAAFATKDRLRTHMVRHEGKVSCNICGKLLSAAYITSHLKTHGQSQSINCNTCKQGISKTCMSEETSNQKQQQQQQQQQQQQQQQQQQHVTSWPGKQVETLRLWEEAVKARKKEAANLCQTSTAATTPVTLTTPFSITSSVSSGTMSNPVTVAAAMSMRSPVNVSSAVNITSPMNIGHPVTITSPLSMTSPLTLTTPVNLPTPVTAPVNIAHPVTITSPMNLPTPMTLAAPLNIAMRPVESMPFLPQALPTSPPW", "length": 521 }, "evidence": [ { "id": "41494287", "url": "http://www.informatics.jax.org/homology/41494287", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q5SXC4-1", "protein_name": "Vascular endothelial zinc finger 1", "gene_name": "Vezf1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MEANWTAFLFQAHEASHHQQQAAQNSLLPLLSSAVEPPDQKPLLPIPITQKPQAAPETLKDAIGIKKEKPKTSFVCTYCSKAFRDSYHLRRHQSCHTGIKLVSRAKKTPTTVVPLISTIAGDSSRTSLVSTIAGILSTVTTSSSGTNPSSSASTTSMPVPQSVKKPSKPVKKNHACEMCGKAFRDVYHLNRHKLSHSDEKPFECPICNQRFKRKDRMTYHVRSHEGGITKPYTCSVCGKGFSRPDHLSCHVKHVHSTERPFKCQTCTAAFATKDRLRTHMVRHEGKVSCNICGKLLSAAYITSHLKTHGQSQSINCNTCKQGISKTCMSEETSNQKQQQQQQQQQQQQQQQHVTSWPGKQVETLRLWEEAVKARKKEAANLCQTSTAATTPVTLTTPFNITSSVSSGTMSNPVTVAAAMSMRSPVNVSSAVNITSPMNIGHPVTITSPLAMTSPLTLTTPVNLPTPVTAPVNIAHPVTITSPMNLPTPMTLAAPLNIAMRPVESMPFLPQALPTSPPW", "length": 518 }, "evidence": [ { "id": "41494287", "url": "http://www.informatics.jax.org/homology/41494287", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "angiogenesis", "id": "GO:0001525", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001525", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZLS0", "url": "https://www.uniprot.org/uniprot/A0A8I5ZLS0" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZLS0", "url": "https://www.uniprot.org/uniprot/A0A8I5ZLS0" } ], "pmid": "21873635" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZLS0", "url": "https://www.uniprot.org/uniprot/A0A8I5ZLS0" } ], "pmid": "" }, { "name": "positive regulation of endothelial cell differentiation", "id": "GO:0045603", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045603", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZLS0", "url": "https://www.uniprot.org/uniprot/A0A8I5ZLS0" } ], "pmid": "" }, { "name": "endothelial cell development", "id": "GO:0001885", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001885", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZLS0", "url": "https://www.uniprot.org/uniprot/A0A8I5ZLS0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZLS0", "url": "https://www.uniprot.org/uniprot/A0A8I5ZLS0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZLS0", "url": "https://www.uniprot.org/uniprot/A0A8I5ZLS0" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZLS0", "url": "https://www.uniprot.org/uniprot/A0A8I5ZLS0" } ], "pmid": "21873635" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5ZLS0", "url": "https://www.uniprot.org/uniprot/A0A8I5ZLS0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 407, "end_pos": 409, "annotation": "n_glycosylation_sequon" }, { "start_pos": 434, "end_pos": 436, "annotation": "n_glycosylation_sequon" }, { "start_pos": 440, "end_pos": 442, "annotation": "n_glycosylation_sequon" }, { "start_pos": 4, "end_pos": 6, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ] }