{
    "uniprot_canonical_ac": "A0A5K7RLP0-1",
    "uniprot_ac": "A0A5K7RLP0",
    "uniprot_id": "MEIOS_MOUSE",
    "mass": {
        "chemical_mass": 65090.0,
        "monoisotopic_mass": 65090.0
    },
    "refseq": {
        "ac": "XP_011249055",
        "name": "basic helix-loop-helix and HMG box domain-containing protein 1 isoform X3",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/XP_011249055"
    },
    "gene_names": [
        {
            "name": "Meiosin",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A5K7RLP0",
            "id": "A0A5K7RLP0"
        },
        {
            "name": "9330180I18; Bhmg1; EG243866; Gm4969",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_011249055",
            "id": "XP_011249055"
        },
        {
            "name": "Bhmg1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A5K7RLP0",
            "id": "A0A5K7RLP0"
        },
        {
            "name": "Gm4969",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/A0A5K7RLP0",
            "id": "A0A5K7RLP0"
        },
        {
            "name": "Meiosin",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_011249055",
            "id": "XP_011249055"
        }
    ],
    "protein_names": [
        {
            "name": "Meiosis initiator protein",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/A0A5K7RLP0#names_and_taxonomy",
            "id": "A0A5K7RLP0"
        },
        {
            "name": "basic helix-loop-helix and HMG box domain-containing protein 1 isoform X3",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_011249055",
            "id": "XP_011249055"
        }
    ],
    "function": [
        {
            "annotation": "Gatekeeper of meiotic initiation in both male and female germ cells (PubMed:32032549). In complex with STRA8, directly activates the transcription of a subset of critical meiotic genes playing a central role in cell-cycle switching from mitosis to meiosis. Temporal expression of MEIOSIN is required for meiotic entry decision (PubMed:32032549).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A5K7RLP0",
                    "url": "https://www.uniprot.org/uniprot/A0A5K7RLP0#function"
                },
                {
                    "database": "PubMed",
                    "id": "32032549",
                    "url": "https://glygen.org/publication/PubMed/32032549"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A5K7RLP0",
                    "url": "https://www.uniprot.org/uniprot/A0A5K7RLP0"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Meiosin",
            "url": "https://www.uniprot.org/uniprot/A0A5K7RLP0",
            "locus": {}
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000085601",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000085601",
            "database": "Bgee"
        },
        {
            "id": "243866",
            "url": "https://www.ncbi.nlm.nih.gov/gene/243866",
            "database": "GeneID"
        },
        {
            "id": "IPR009071",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR009071",
            "database": "InterPro"
        },
        {
            "id": "IPR011598",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011598",
            "database": "InterPro"
        },
        {
            "id": "IPR036638",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036638",
            "database": "InterPro"
        },
        {
            "id": "IPR036910",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036910",
            "database": "InterPro"
        },
        {
            "id": "3647482",
            "url": "http://www.informatics.jax.org/marker/MGI:3647482",
            "database": "MGI"
        },
        {
            "id": "KQYIRAC",
            "url": "https://omabrowser.org/oma/group/KQYIRAC/",
            "database": "OMA"
        },
        {
            "id": "1031202at2759",
            "url": "http://www.orthodb.org/?query=1031202at2759",
            "database": "OrthoDB"
        },
        {
            "id": "PF00505",
            "url": "http://pfam.xfam.org/family/PF00505",
            "database": "Pfam"
        },
        {
            "id": "XP_011249055",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_011249055",
            "database": "RefSeq"
        },
        {
            "id": "A0A5K7RLP0",
            "url": "https://www.uniprot.org/uniprot/A0A5K7RLP0",
            "database": "UniProtKB"
        },
        {
            "id": "A0A5K7RLP0-1",
            "url": "https://www.uniprot.org/uniprot/A0A5K7RLP0-1",
            "database": "UniProtKB"
        },
        {
            "id": "A0A5K7RLP0-2",
            "url": "https://www.uniprot.org/uniprot/A0A5K7RLP0-2",
            "database": "UniProtKB"
        },
        {
            "id": "D6RG70",
            "url": "https://www.uniprot.org/uniprot/D6RG70",
            "database": "UniProtKB"
        },
        {
            "id": "D6RG70-1",
            "url": "https://www.uniprot.org/uniprot/D6RG70-1",
            "database": "UniProtKB"
        }
    ],
    "sequence": {
        "sequence": "MLGSDKFSCFSDQHRARSPSPTDRKDKKNHTNKLRELALLIPVTMKTRDKKYTKKEILLRVLHYIQYLQRNIDMTKALLKLHSSNGKGRFVGPGLNPSAGQTQQQHSTPSSSQKPSLWSTSSKPRKKKFTRVSEHPSWPYNPRRSLALDQAENPNTIHPGLKEENEECATYPGVLSPSTYPTTEPSVSEGDGQGAQLVFLDMAQNIFAYDILSDHAVEVQGGEPNADIKVQRSFFLTRAQPCVSSCRQKLFLCTSSEADKEAPDSDPWLPVWTSEDSPNGSPLALGSSQINTWHVADYLNEILGVSSSLFSSPSKILPDHVLEDGTYFLTEGLLESSPATCEVESPQEKEVSSEGPTGPPNFQSSVSLDHCYLSLSENVKVLSNCGSSSESTDTESLWGQEEVRGVATYPRRTGVFSLAQPSVLQQANPEGLQTSSDEDRDYTWTPTGQSSGLPVASKKIKKVQASQGPVKPKDSRKACPGQVKKKCVNGFIMFCRMNRKQYIRACPGTASTAATKDLAQLWRGMTLEEKKPYCTKARRFSRQNNRIVKQENSSSEDDDGETPKPFYQLLAEKAQVSLGLTSLPTPNCQ",
        "length": 589,
        "header": "sp|A0A5K7RLP0-1|MEIOS_MOUSE Isoform 1 of Meiosis initiator protein  OS=Mus musculus OX=10090 GN=Meiosin PE=1 SV=1 CANONICAL=A0A5K7RLP0-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A5K7RLP0-1",
            "url": "https://www.uniprot.org/uniprot/A0A5K7RLP0#A0A5K7RLP0-1",
            "sequence": {
                "sequence": "MLGSDKFSCFSDQHRARSPSPTDRKDKKNHTNKLRELALLIPVTMKTRDKKYTKKEILLRVLHYIQYLQRNIDMTKALLKLHSSNGKGRFVGPGLNPSAGQTQQQHSTPSSSQKPSLWSTSSKPRKKKFTRVSEHPSWPYNPRRSLALDQAENPNTIHPGLKEENEECATYPGVLSPSTYPTTEPSVSEGDGQGAQLVFLDMAQNIFAYDILSDHAVEVQGGEPNADIKVQRSFFLTRAQPCVSSCRQKLFLCTSSEADKEAPDSDPWLPVWTSEDSPNGSPLALGSSQINTWHVADYLNEILGVSSSLFSSPSKILPDHVLEDGTYFLTEGLLESSPATCEVESPQEKEVSSEGPTGPPNFQSSVSLDHCYLSLSENVKVLSNCGSSSESTDTESLWGQEEVRGVATYPRRTGVFSLAQPSVLQQANPEGLQTSSDEDRDYTWTPTGQSSGLPVASKKIKKVQASQGPVKPKDSRKACPGQVKKKCVNGFIMFCRMNRKQYIRACPGTASTAATKDLAQLWRGMTLEEKKPYCTKARRFSRQNNRIVKQENSSSEDDDGETPKPFYQLLAEKAQVSLGLTSLPTPNCQ",
                "length": 589,
                "header": "sp|A0A5K7RLP0-1|MEIOS_MOUSE Isoform 1 of Meiosis initiator protein  OS=Mus musculus OX=10090 GN=Meiosin PE=1 SV=1 CANONICAL=A0A5K7RLP0-1"
            },
            "locus": {}
        },
        {
            "isoform_ac": "A0A5K7RLP0-2",
            "url": "https://www.uniprot.org/uniprot/A0A5K7RLP0#A0A5K7RLP0-2",
            "sequence": {
                "sequence": "MLGSDKFSCFSDQHRARSPSPTDRKDKKNHTNKLRELALLIPVTMKTRDKKYTKKEILLRVLHYIQYLQRNIDMTKALLKLHSSNGKGRFVGPGLNPSAGQTQQQHSTPSSSQKPSLWSTSSKPRKKKFTRVSEHPSWPYNPRRSLALDQAENPNTIHPGLKEENEECATYPGVLSPSTYPTTEPSVSEGDGQGAQLVFLDMAQNIFAYDILSDHAVEVQGGEPNADIKVQRSFFLTRAQPCVSSCRQKLFLCTSSEADKEAPDSDPWLPVWTSEDSPNGSPLALGSSQINTWHVADYLNEILGVSSSLFSSPSKILPDHVLEDGTYFLTEGLLESSPATCEVESPQEKEVSSEGPTGPPNFQSSVSLDHCYLSLSENVKVLSNCGSSSESTDTESLWGQEEQANPEGLQTSSDEDRDYTWTPTGQSSGLPVASKKIKKVQASQGPVKPKDSRKACPGQVKKKCVNGFIMFCRMNRKQYIRACPGTASTAATKDLAQLWRGMTLEEKKPYCTKARRFSRQNNRIVKQENSSSEDDDGETPKPFYQLLAEKAQVSLGLTSLPTPNCQ",
                "length": 566,
                "header": "sp|A0A5K7RLP0-2|MEIOS_MOUSE Isoform 2 of Meiosis initiator protein  OS=Mus musculus OX=10090 GN=Meiosin PE=1 SV=1 CANONICAL=A0A5K7RLP0-1"
            },
            "locus": {
                "chromosome": "7",
                "start_pos": 18848406,
                "end_pos": 18832974,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000141380",
                        "url": "https://www.ensembl.org/id/ENSMUST00000141380"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000115575",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000115575"
                    }
                ]
            }
        },
        {
            "isoform_ac": "D6RG70-1",
            "url": "https://www.uniprot.org/uniprot/A0A5K7RLP0#D6RG70-1",
            "sequence": {
                "sequence": "MLGSDKFSCFSDQHRARSPSPTDRKDKKNHTNKLRELALLIPVTMKTRDKKYTKGQV",
                "length": 57,
                "header": "tr|D6RG70-1|MEIOS_MOUSE Computationally mapped isoform of Meiosis initiator protein  OS=Mus musculus OX=10090 GN=Meiosin PE=1 SV=1 CANONICAL=A0A5K7RLP0-1"
            },
            "locus": {
                "chromosome": "7",
                "start_pos": 18848406,
                "end_pos": 18839763,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000127433.7",
                        "url": "https://www.ensembl.org/id/ENSMUST00000127433.7"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000115597.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000115597.2"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian Germ Cells.",
            "journal": "Dev. Cell",
            "date": "2020",
            "authors": "Matsuura K., Araki K., Fujimura S., Sugimoto M., Takeda N., Yamane M., Hosokawa M., Niwa H., Usuki S., Ko M.S.H., Chuma S., Tani N., Ishiguro K.I.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A5K7RLP0",
                    "url": "https://www.uniprot.org/uniprot/A0A5K7RLP0"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "32032549",
                    "url": "https://glygen.org/publication/PubMed/32032549"
                }
            ]
        }
    ],
    "pathway": [],
    "orthologs": [
        {
            "uniprot_canonical_ac": "C9JSJ3-1",
            "protein_name": "Meiosis initiator protein",
            "gene_name": "MEIOSIN",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MFGSSRYLGSSEQPRANSLGPSDRTLVLCSLVEGEDKVNPSEPHGLRMEEKWLLKGKLRNQRNQNKLLSPNKKQRKNHTSKLQELALLLPIALKTGTKKLTKKEILVHVLQYIQYLQRNIDAAKALFKCHITTGEGGLAGLGQKPAWGPARRRRHSTPSSSPSSQKSCLQGACQKPRKKKLTQASESQTRTPKPRRSLALNKPEKLVAPSPDQKGSGTGGTTTPPRCPDSCGHPRPASSSPPGDRKGGQSQLTLLDLAEDTIHCDISSCWCQGSVQDDAPFPALLAQEDVARIHFLNKTQPHPRQKLVFYDSSEDVDKGSLDADPWLPAWTPENSPQGSPLFLGPPQIDVWSGTGHPSEILGLSPSLFSSPGKLLPDEILEDDMEYLTQAAFFEEVCLDLESSPSAYTQEAPQEKDTASKAPKDPPESHSLHRSSVSLDHCYLSLSGNSKAPSSSSSSSSSSSSSEDSDSEPLWKQREDMQANPVGTPGSSEEDEDTTWTPTRLASPLLAAEKKATKGQVARAPVKPKEKKKGPCPPQMKKKCVNGFIMFCRMNRKQYIRSCPGTASTAATKELAQLWRVMTQQERRPYCTKARRFSRQHNRIVKQDGSSSEAEDWETPKPFYQLLAEKALPLPPHLQ",
                "length": 638
            },
            "evidence": [
                {
                    "id": "41504080",
                    "url": "http://www.informatics.jax.org/homology/41504080",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 2,
                "go_terms": [
                    {
                        "name": "DNA binding",
                        "id": "GO:0003677",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A5K7RLP0",
                                "url": "https://www.uniprot.org/uniprot/A0A5K7RLP0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein dimerization activity",
                        "id": "GO:0046983",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046983",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A5K7RLP0",
                                "url": "https://www.uniprot.org/uniprot/A0A5K7RLP0"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 1,
                "go_terms": [
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A5K7RLP0",
                                "url": "https://www.uniprot.org/uniprot/A0A5K7RLP0"
                            }
                        ],
                        "pmid": "32032549"
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 6,
                "go_terms": [
                    {
                        "name": "regulation of transcription by RNA polymerase II",
                        "id": "GO:0006357",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A5K7RLP0",
                                "url": "https://www.uniprot.org/uniprot/A0A5K7RLP0"
                            }
                        ],
                        "pmid": "32032549"
                    },
                    {
                        "name": "spermatogenesis",
                        "id": "GO:0007283",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A5K7RLP0",
                                "url": "https://www.uniprot.org/uniprot/A0A5K7RLP0"
                            }
                        ],
                        "pmid": "32032549"
                    },
                    {
                        "name": "cellular response to retinoic acid",
                        "id": "GO:0071300",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071300",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A5K7RLP0",
                                "url": "https://www.uniprot.org/uniprot/A0A5K7RLP0"
                            }
                        ],
                        "pmid": "32032549"
                    },
                    {
                        "name": "oogenesis",
                        "id": "GO:0048477",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048477",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A5K7RLP0",
                                "url": "https://www.uniprot.org/uniprot/A0A5K7RLP0"
                            }
                        ],
                        "pmid": "32032549"
                    },
                    {
                        "name": "meiotic cell cycle",
                        "id": "GO:0051321",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051321",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A5K7RLP0",
                                "url": "https://www.uniprot.org/uniprot/A0A5K7RLP0"
                            }
                        ],
                        "pmid": "32032549"
                    },
                    {
                        "name": "activation of meiosis",
                        "id": "GO:0090427",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090427",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "A0A5K7RLP0",
                                "url": "https://www.uniprot.org/uniprot/A0A5K7RLP0"
                            }
                        ],
                        "pmid": "32032549"
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 279,
            "end_pos": 281,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 29,
            "end_pos": 31,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 552,
            "end_pos": 554,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ]
}